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CMBL Gene

protein-coding   GIFtS: 54
GCID: GC05M010275

Carboxymethylenebutenolidase Homolog (Pseudomonas)

(Previous name: carboxymethylenebutenolidase-like (Pseudomonas))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxymethylenebutenolidase Homolog (Pseudomonas)1 2
Carboxymethylenebutenolidase-Like (Pseudomonas)1 2
JS-12
Carboxymethylenebutenolidase Homolog2
EC 3.1.-.-3

External Ids:    HGNC: 250901   Entrez Gene: 1341472   Ensembl: ENSG000001642377   OMIM: 6133795   UniProtKB: Q96DG63   

Export aliases for CMBL gene to outside databases

Previous GC identifer: GC05M010330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMBL Gene:
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver
cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the
medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 (PubMed 20177059)).(supplied by OMIM, Apr
2010)

GeneCards Summary for CMBL Gene:
CMBL (carboxymethylenebutenolidase homolog (Pseudomonas)) is a protein-coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: CMBL_HUMAN, Q96DG6
Function: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active
metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam
antibiotics faropenem medoxomil and lenampicillin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMBL gene promoter:
         TBP   HNF-4alpha2   STAT5A   Nkx2-5   Tal-1beta   HNF-4alpha1   Evi-1   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMBL promoter sequence
   Search Chromatin IP Primers for CMBL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

CMBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMBL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M010275:  view genomic region     (about GC identifiers)

Start:
10,275,987 bp from pter      End:
10,308,168 bp from pter
Size:
32,182 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CMBL_HUMAN, Q96DG6 (See protein sequence)
Recommended Name: Carboxymethylenebutenolidase homolog  
Size: 245 amino acids; 28048 Da
Secondary accessions: D3DTC7 Q8TED6

Explore the universe of human proteins at neXtProt for CMBL: NX_Q96DG6

Explore proteomics data for CMBL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CMBL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620164.1  
    ENSEMBL proteins: 
     ENSP00000296658  

    CMBL Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002925 Dienelactn_hydro

    Graphical View of Domain Structure for InterPro Entry Q96DG6

    ProtoNet protein and cluster: Q96DG6

    1 Blocks protein domain: IPB002925 Dienelactone hydrolase

    UniProtKB/Swiss-Prot: CMBL_HUMAN, Q96DG6
    Similarity: Belongs to the dienelactone hydrolase family


    Find genes that share domains with CMBL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CMBL_HUMAN, Q96DG6
    Function: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active
    metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam
    antibiotics faropenem medoxomil and lenampicillin
    Enzyme regulation: Strongly inhibited by p-chloromercuribenzoate (PCMB). Partially inhibited by
    bis-p-nitrophenylphosphate (BNPP). Not inhibited by DFP, PMSF, eserine or EDTA
    Biophysicochemical properties: Kinetic parameters: KM=170 uM for olmesartan medoxomil; KM=283 uM for faropenem
    medoxomil; KM=63.4 uM for lenampicillin; Vmax=24.6 nmol/min/mg enzyme toward olmesartan medoxomil; Vmax=16.4
    nmol/min/mg enzyme toward faropenem medoxomil; Vmax=4 nmol/min/mg enzyme toward lenampicillin;

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with CMBL           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMBL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CMBL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CMBL
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    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CMBL using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CMBL:
    hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCMBL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CMBL
    Predesigned siRNA for gene silencing in human, mouse, rat CMBL

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CMBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CMBL (NM_138809)
    Sino Biological Human cDNA Clone for CMBL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMBL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CMBL 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMBL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CMBL_HUMAN, Q96DG6: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CMBL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CMBL About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with CMBL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CMBL):
        Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMBL
    Interactions:

        Search GeneGlobe Interaction Network for CMBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CMBL (Q96DG63 ENSP000002966584) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494073, ENSP000003771414I2D: score=2 STRING: ENSP00000377141
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    PUF60Q9UHX13, ENSP000003220164I2D: score=1 STRING: ENSP00000322016
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMBL

    1 HMDB Compound for CMBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMBL gene: 
    NM_138809.3  

    Unigene Cluster for CMBL:

    Carboxymethylenebutenolidase homolog (Pseudomonas)
    Hs.192586  [show with all ESTs]
    Unigene Representative Sequence: NM_138809
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503834 ENST00000296658(uc003jes.3) ENST00000510532 ENST00000511963
    ENST00000506821 ENST00000514202 ENST00000506224
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CMBL using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CMBL:
    hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCMBL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CMBL
    Predesigned siRNA for gene silencing in human, mouse, rat CMBL
    Clone
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    OriGene clones in human, mouse for CMBL (see all 6)
    OriGene ORF clones in mouse, rat for CMBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CMBL (NM_138809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMBL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CMBL
    OriGene qSTAR qPCR primer pairs in human, mouse for CMBL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMBL
      QuantiTect SYBR Green Assays in human, mouse, rat CMBL
      QuantiFast Probe-based Assays in human, mouse, rat CMBL

    Additional mRNA sequence: 

    AJ278125.1 AK074197.1 AK315390.1 BC001573.1 BX647141.1 

    8 DOTS entries:

    DT.40307419  DT.100038135  DT.100782742  DT.100038133  DT.100782744  DT.120796283  DT.100782745  DT.92351242 

    Selected AceView cDNA sequences (see all 143):

    CK431244 BX358560 AL036039 AW300032 CF144508 CF144457 AA317168 CB128136 
    BC001573 AA563626 BU165988 BE546579 AW188545 BM784608 AA112034 AW612048 
    BM549154 BX370060 BE177398 BM988489 BX350197 BQ927626 Z38676 BE280583 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CMBL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:              -           -                 -                     
    SP2:                          -                 -     -               
    SP3:              -           -                                       
    SP4:              -                                                   


    ECgene alternative splicing isoforms for CMBL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMBL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTATAAAC
    CMBL Expression
    About this image


    CMBL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    CMBL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMBL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192586

    UniProtKB/Swiss-Prot: CMBL_HUMAN, Q96DG6
    Tissue specificity: Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon.
    Present in liver and intestine (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMBL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CMBL gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmbl1 , 5 carboxymethylenebutenolidase-like (Pseudomonas)1, 5 81.9(n)1
    82.86(a)1
      15 (13.00 cM)5
    695741  NM_181588.31  NP_853619.11 
     315687915 
    chicken
    (Gallus gallus)
    Aves CMBL1 carboxymethylenebutenolidase homolog (Pseudomonas) 68.71(n)
    61.63(a)
      420928  XM_004935118.1  XP_004935175.1 
    lizard
    (Anolis carolinensis)
    Reptilia CMBL6
    carboxymethylenebutenolidase homolog (Pseudomonas)...
    62(a)
    1 ↔ 1
    4(66740839-66780256)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.262922 Xenopus laevis transcribed sequence with weak similarity more 72.48(n)    CD325620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmbl1 carboxymethylenebutenolidase-like (Pseudomonas) 65.44(n)
    64.34(a)
      100151256  NM_001109832.1  NP_001103302.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AIM2(YAL049C)4 Cytoplasmic protein involved in mitochondrial function more   --   1(52595-51855) 851248  NP_009350.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G354201 AT1G35420 44.6(n)
    32.41(a)
      840434  NM_001198211.1  NP_001185140.1 


    ENSEMBL Gene Tree for CMBL (if available)
    TreeFam Gene Tree for CMBL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMBL gene

    Find genes that share paralogs with CMBL           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CMBL
    PGOHUM00000241086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMBL (see all 802)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996038511,2
    C--10277211(+) TTTTG-/TTTTTT 1 -- ds50010--------
    rs1125707841,2
    C,F--10277296(+) ACCTCC/TGGGTT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs787764631,2
    C,F--10277583(+) AAAGAT/CAGAGG 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs113060501,2
    C--10277592(+) GGAAC-/AAAAAA 1 -- ds50010--------
    rs1901038871,2
    --10277629(+) GATTCA/GTTACA 1 -- ds50010--------
    rs737413621,2
    C,F--10277799(+) CCTTCG/ATTTAT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs12994241,2
    C,H--10277810(-) TAGACA/CAACAG 1 -- ut316Minor allele frequency- C:0.00MN NS EA NA 604
    rs1459047251,2
    C--10277874(+) TACTTC/TTATCT 1 -- ut310--------
    rs1381901151,2
    --10277911(+) ATTTGA/CCCAAA 1 -- ut310--------
    rs595269981,2
    C,F--10278055(+) CCGACA/GCCGTT 1 -- ut311Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for CMBL (10275987 - 10308168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CMBL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv32585CNV Loss17666407
    nsv823000CNV Gain20364138
    nsv881429CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMBL
    DNA2.0 Custom Variant and Variant Library Synthesis for CMBL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613379    OMIM disorders: --


    Find genes that share disorders with CMBL           About GenesLikeMe

    Genetic Association Database (GAD): CMBL

    Export disorders for CMBL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMBL gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CMBL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. (PubMed id 20177059)1, 2, 3 Ishizuka T.... Okazaki O. (J. Biol. Chem. 2010)
    2. Nucleotide sequence and expression of clcD, a plasmid-borne dienelactone hydrolase gene from Pseudomonas sp. strain B13. (PubMed id 3804974)1, 3 Frantz B....Chakrabarty A.M. (J. Bacteriol. 1987)
    3. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (J. Proteome Res. 2010)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134147 HGNC: 25090 AceView: LOC134147 Ensembl:ENSG00000164237 euGenes: HUgn134147
    ECgene: CMBL Kegg: 134147 H-InvDB: CMBL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CMBL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMBL gene:
    Search GeneIP for patents involving CMBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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