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Aliases for CMBL Gene

Aliases for CMBL Gene

  • Carboxymethylenebutenolidase Homolog (Pseudomonas) 2 3
  • Carboxymethylenebutenolidase-Like (Pseudomonas) 2 3
  • Carboxymethylenebutenolidase Homolog 3
  • EC 3.1.-.- 4
  • JS-1 3

External Ids for CMBL Gene

Previous GeneCards Identifiers for CMBL Gene

  • GC05M010330

Summaries for CMBL Gene

Entrez Gene Summary for CMBL Gene

  • CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]

GeneCards Summary for CMBL Gene

CMBL (Carboxymethylenebutenolidase Homolog (Pseudomonas)) is a Protein Coding gene. Among its related pathways are Metabolism. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for CMBL Gene

  • Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMBL Gene

Genomics for CMBL Gene

Regulatory Elements for CMBL Gene

Genomic Location for CMBL Gene

Start:
10,275,875 bp from pter
End:
10,308,056 bp from pter
Size:
32,182 bases
Orientation:
Minus strand

Genomic View for CMBL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMBL Gene

Proteins for CMBL Gene

  • Protein details for CMBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DG6-CMBL_HUMAN
    Recommended name:
    Carboxymethylenebutenolidase homolog
    Protein Accession:
    Q96DG6
    Secondary Accessions:
    • D3DTC7
    • Q8TED6

    Protein attributes for CMBL Gene

    Size:
    245 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CMBL Gene

Proteomics data for CMBL Gene at MOPED

Post-translational modifications for CMBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMBL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CMBL Gene

Domains for CMBL Gene

Protein Domains for CMBL Gene

Suggested Antigen Peptide Sequences for CMBL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DG6

UniProtKB/Swiss-Prot:

CMBL_HUMAN :
  • Q96DG6
Family:
  • Belongs to the dienelactone hydrolase family.
genes like me logo Genes that share domains with CMBL: view

No data available for Gene Families for CMBL Gene

Function for CMBL Gene

Molecular function for CMBL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=170 uM for olmesartan medoxomil {ECO:0000269 PubMed:20177059}; KM=283 uM for faropenem medoxomil {ECO:0000269 PubMed:20177059}; KM=63.4 uM for lenampicillin {ECO:0000269 PubMed:20177059}; Vmax=24.6 nmol/min/mg enzyme toward olmesartan medoxomil {ECO:0000269 PubMed:20177059}; Vmax=16.4 nmol/min/mg enzyme toward faropenem medoxomil {ECO:0000269 PubMed:20177059}; Vmax=4 nmol/min/mg enzyme toward lenampicillin {ECO:0000269 PubMed:20177059};
UniProtKB/Swiss-Prot EnzymeRegulation: Strongly inhibited by p-chloromercuribenzoate (PCMB). Partially inhibited by bis-p-nitrophenylphosphate (BNPP). Not inhibited by DFP, PMSF, eserine or EDTA
UniProtKB/Swiss-Prot Function: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.

Enzyme Numbers (IUBMB) for CMBL Gene

Gene Ontology (GO) - Molecular Function for CMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CMBL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMBL

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CMBL Gene

Localization for CMBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMBL Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMBL Gene COMPARTMENTS Subcellular localization image for CMBL gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CMBL: view

Pathways for CMBL Gene

SuperPathways for CMBL Gene

Superpath Contained pathways
1 Metabolism
genes like me logo Genes that share pathways with CMBL: view

Pathways by source for CMBL Gene

1 KEGG pathway for CMBL Gene

Gene Ontology (GO) - Biological Process for CMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CMBL: view

Compounds for CMBL Gene

(1) HMDB Compounds for CMBL Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with CMBL: view

Transcripts for CMBL Gene

Unigene Clusters for CMBL Gene

Carboxymethylenebutenolidase homolog (Pseudomonas):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMBL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMBL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for CMBL Gene

GeneLoc Exon Structure for
CMBL
ECgene alternative splicing isoforms for
CMBL

Expression for CMBL Gene

mRNA expression in normal human tissues for CMBL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMBL Gene

This gene is overexpressed in Kidney - Cortex (7.4), Muscle - Skeletal (5.7), and Liver (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMBL Gene

SOURCE GeneReport for Unigene cluster for CMBL Gene Hs.192586

mRNA Expression by UniProt/SwissProt for CMBL Gene

Q96DG6-CMBL_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level).
genes like me logo Genes that share expressions with CMBL: view

In Situ Assay Products

Orthologs for CMBL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CMBL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMBL 35
  • 97.78 (n)
  • 97.44 (a)
CMBL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMBL 35
  • 86.8 (n)
  • 87.35 (a)
CMBL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMBL 35
  • 87.35 (n)
  • 87.35 (a)
CMBL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmbl 35
  • 81.9 (n)
  • 82.86 (a)
Cmbl 16
Cmbl 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMBL 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMBL 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmbl 35
  • 82.59 (n)
  • 84.49 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
CMBL 35
  • 68.71 (n)
  • 61.63 (a)
lizard
(Anolis carolinensis)
Reptilia CMBL 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26292 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cmbl 35
  • 68.3 (n)
  • 66.53 (a)
MGC76315 35
zebrafish
(Danio rerio)
Actinopterygii cmbl 35
  • 65.44 (n)
  • 64.34 (a)
cmbl 36
  • 64 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM2 36
  • 25 (a)
OneToOne
AIM2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G35420 35
  • 44.6 (n)
  • 32.41 (a)
Species with no ortholog for CMBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMBL Gene

ENSEMBL:
Gene Tree for CMBL (if available)
TreeFam:
Gene Tree for CMBL (if available)

Paralogs for CMBL Gene

Pseudogenes.org Pseudogenes for CMBL Gene

genes like me logo Genes that share paralogs with CMBL: view

No data available for Paralogs for CMBL Gene

Variants for CMBL Gene

Sequence variations from dbSNP and Humsavar for CMBL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9333 -- 10,279,318(+) ATTAG(A/G)TCAAT utr-variant-3-prime
rs598483 -- 10,309,344(-) gatgg(C/G)accac upstream-variant-2KB
rs1287734 -- 10,279,096(-) GAAAC(A/T)CTGCA utr-variant-3-prime
rs1287735 -- 10,278,491(-) ggggg(A/G)tttag utr-variant-3-prime
rs1287736 -- 10,278,291(-) ggaac(A/T)gtgag utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CMBL Gene

Variant ID Type Subtype PubMed ID
nsv881429 CNV Gain 21882294
esv32585 CNV Loss 17666407
nsv823000 CNV Gain 20364138

Relevant External Links for CMBL Gene

HapMap Linkage Disequilibrium report
CMBL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMBL Gene

Disorders for CMBL Gene

Relevant External Links for CMBL

Genetic Association Database (GAD)
CMBL
genes like me logo Genes that share disorders with CMBL: view

No data available for UniProtKB/Swiss-Prot for CMBL Gene

Publications for CMBL Gene

  1. Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. (PMID: 20177059) Ishizuka T. … Okazaki O. (J. Biol. Chem. 2010) 2 3 4
  2. Nucleotide sequence and expression of clcD, a plasmid-borne dienelactone hydrolase gene from Pseudomonas sp. strain B13. (PMID: 3804974) Frantz B. … Chakrabarty A.M. (J. Bacteriol. 1987) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma. (PMID: 16328025) Fatima S. … Tang J.C. (Int. J. Mol. Med. 2006) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CMBL Gene

Sources for CMBL Gene

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