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Aliases for CMBL Gene

Aliases for CMBL Gene

  • Carboxymethylenebutenolidase Homolog (Pseudomonas) 2 3 5
  • Carboxymethylenebutenolidase-Like (Pseudomonas) 2 3
  • EC 3.1.-.- 4
  • JS-1 3

External Ids for CMBL Gene

Previous GeneCards Identifiers for CMBL Gene

  • GC05M010330

Summaries for CMBL Gene

Entrez Gene Summary for CMBL Gene

  • CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]

GeneCards Summary for CMBL Gene

CMBL (Carboxymethylenebutenolidase Homolog (Pseudomonas)) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for CMBL Gene

  • Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMBL Gene

Genomics for CMBL Gene

Regulatory Elements for CMBL Gene

Enhancers for CMBL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CMBL on UCSC Golden Path with GeneCards custom track

Promoters for CMBL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMBL on UCSC Golden Path with GeneCards custom track

Genomic Location for CMBL Gene

Chromosome:
5
Start:
10,275,875 bp from pter
End:
10,308,056 bp from pter
Size:
32,182 bases
Orientation:
Minus strand

Genomic View for CMBL Gene

Genes around CMBL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMBL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMBL Gene

Proteins for CMBL Gene

  • Protein details for CMBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DG6-CMBL_HUMAN
    Recommended name:
    Carboxymethylenebutenolidase homolog
    Protein Accession:
    Q96DG6
    Secondary Accessions:
    • D3DTC7
    • Q8TED6

    Protein attributes for CMBL Gene

    Size:
    245 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CMBL Gene

Proteomics data for CMBL Gene at MOPED

Post-translational modifications for CMBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMBL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CMBL Gene

Domains & Families for CMBL Gene

Protein Domains for CMBL Gene

Suggested Antigen Peptide Sequences for CMBL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DG6

UniProtKB/Swiss-Prot:

CMBL_HUMAN :
  • Belongs to the dienelactone hydrolase family.
Family:
  • Belongs to the dienelactone hydrolase family.
genes like me logo Genes that share domains with CMBL: view

No data available for Gene Families for CMBL Gene

Function for CMBL Gene

Molecular function for CMBL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=170 uM for olmesartan medoxomil {ECO:0000269 PubMed:20177059}; KM=283 uM for faropenem medoxomil {ECO:0000269 PubMed:20177059}; KM=63.4 uM for lenampicillin {ECO:0000269 PubMed:20177059}; Vmax=24.6 nmol/min/mg enzyme toward olmesartan medoxomil {ECO:0000269 PubMed:20177059}; Vmax=16.4 nmol/min/mg enzyme toward faropenem medoxomil {ECO:0000269 PubMed:20177059}; Vmax=4 nmol/min/mg enzyme toward lenampicillin {ECO:0000269 PubMed:20177059};
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by p-chloromercuribenzoate (PCMB). Partially inhibited by bis-p-nitrophenylphosphate (BNPP). Not inhibited by DFP, PMSF, eserine or EDTA.
UniProtKB/Swiss-Prot Function:
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.

Enzyme Numbers (IUBMB) for CMBL Gene

genes like me logo Genes that share phenotypes with CMBL: view

Animal Model Products

miRNA for CMBL Gene

miRTarBase miRNAs that target CMBL

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMBL Gene

Localization for CMBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMBL Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMBL Gene COMPARTMENTS Subcellular localization image for CMBL gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for CMBL Gene

Pathways & Interactions for CMBL Gene

genes like me logo Genes that share pathways with CMBL: view

Pathways by source for CMBL Gene

1 KEGG pathway for CMBL Gene

Gene Ontology (GO) - Biological Process for CMBL Gene

None

No data available for SIGNOR curated interactions for CMBL Gene

Drugs & Compounds for CMBL Gene

(19) Additional Compounds for CMBL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,3,5-Trichlorodienelactone
2,3,5-Trichloromaleylacetate
2,5-Dichloro-4-oxohex-2-enedioate
2,5-Dichloro-carboxymethylenebut-2-en-4-olide
2-Chloro-5-methyl-cis-dienelactone
genes like me logo Genes that share compounds with CMBL: view

Transcripts for CMBL Gene

Unigene Clusters for CMBL Gene

Carboxymethylenebutenolidase homolog (Pseudomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMBL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for CMBL Gene

GeneLoc Exon Structure for
CMBL
ECgene alternative splicing isoforms for
CMBL

Expression for CMBL Gene

mRNA expression in normal human tissues for CMBL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMBL Gene

This gene is overexpressed in Kidney - Cortex (x7.4), Muscle - Skeletal (x5.7), and Liver (x4.7).

Protein differential expression in normal tissues from HIPED for CMBL Gene

This gene is overexpressed in Liver, secretome (16.9), Kidney (14.4), and Liver (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMBL Gene



SOURCE GeneReport for Unigene cluster for CMBL Gene Hs.192586

mRNA Expression by UniProt/SwissProt for CMBL Gene

Q96DG6-CMBL_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level).
genes like me logo Genes that share expression patterns with CMBL: view

Protein tissue co-expression partners for CMBL Gene

Primer Products

Orthologs for CMBL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CMBL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CMBL 35
  • 86.8 (n)
  • 87.35 (a)
CMBL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMBL 35
  • 87.35 (n)
  • 87.35 (a)
CMBL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmbl 35
  • 81.9 (n)
  • 82.86 (a)
Cmbl 16
Cmbl 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CMBL 35
  • 97.78 (n)
  • 97.44 (a)
CMBL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmbl 35
  • 82.59 (n)
  • 84.49 (a)
oppossum
(Monodelphis domestica)
Mammalia CMBL 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMBL 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMBL 35
  • 68.71 (n)
  • 61.63 (a)
-- 36
  • 54 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CMBL 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmbl 35
  • 68.3 (n)
  • 66.53 (a)
MGC76315 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26292 35
zebrafish
(Danio rerio)
Actinopterygii cmbl 35
  • 65.44 (n)
  • 64.34 (a)
cmbl 36
  • 64 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM2 36
  • 25 (a)
OneToOne
AIM2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G35420 35
  • 44.6 (n)
  • 32.41 (a)
Species with no ortholog for CMBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMBL Gene

ENSEMBL:
Gene Tree for CMBL (if available)
TreeFam:
Gene Tree for CMBL (if available)

Paralogs for CMBL Gene

Pseudogenes.org Pseudogenes for CMBL Gene

genes like me logo Genes that share paralogs with CMBL: view

No data available for Paralogs for CMBL Gene

Variants for CMBL Gene

Sequence variations from dbSNP and Humsavar for CMBL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35489000 - 10,286,356(-) CGTCT(A/G)TGGTA reference, missense
rs9333 -- 10,279,318(+) ATTAG(A/G)TCAAT utr-variant-3-prime
rs2662525 -- 10,304,105(-) gggag(A/T)atagg intron-variant
rs2662526 -- 10,289,618(-) GTGCT(A/G)AGGGC intron-variant
rs1287734 -- 10,279,096(-) GAAAC(A/T)CTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CMBL Gene

Variant ID Type Subtype PubMed ID
nsv881429 CNV Gain 21882294
esv32585 CNV Loss 17666407
nsv823000 CNV Gain 20364138

Variation tolerance for CMBL Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMBL Gene

HapMap Linkage Disequilibrium report
CMBL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMBL Gene

Disorders for CMBL Gene

Relevant External Links for CMBL

Genetic Association Database (GAD)
CMBL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMBL

No disorders were found for CMBL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMBL Gene

Publications for CMBL Gene

  1. Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. (PMID: 20177059) Ishizuka T. … Okazaki O. (J. Biol. Chem. 2010) 2 3 4 67
  2. Nucleotide sequence and expression of clcD, a plasmid-borne dienelactone hydrolase gene from Pseudomonas sp. strain B13. (PMID: 3804974) Frantz B. … Chakrabarty A.M. (J. Bacteriol. 1987) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PMID: 23184937) Xie Y. … Cong F. (J. Biol. Chem. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for CMBL Gene

Sources for CMBL Gene

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