Aliases for CMA1 Gene
External Ids for CMA1 Gene
Previous GeneCards Identifiers for CMA1 Gene
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for CMA1 Gene
CMA1 (Chymase 1, Mast Cell) is a Protein Coding gene. Diseases associated with CMA1 include alpha-1-antichymotrypsin deficiency and urticaria pigmentosa. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include serine-type endopeptidase activity and peptide binding. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for CMA1 Gene
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion