CMA1 Gene
protein-coding GIFtS: 67
GCID: GC14M024974
|
|
chymase 1, mast cell
| |
Aliases
for CMA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chymase 1, Mast Cell1 2 | | Chymase 1 Preproprotein Transcript E2 | | Mast Cell Protease I2 3 | | Chymase 1 Preproprotein Transcript I2 | | CYH2 3 | | Chymase, Heart2 | | EC 3.4.21.393 8 | | Chymase, Mast Cell2 | | MCT12 | | Alpha-Chymase1 | | Alpha-Chymase1 | | CYM3 | | Chymase1 | | EC 3.4.218 |
Export aliases for CMA1 gene to outside databasesPrevious GC identifers: GC14M022347 GC14M018762 GC14M022964 GC14M024044 GC14M005089 |
Summaries
for CMA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CMA1:
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mastcells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal glandsecretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather thanangiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptideangiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension,cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. Thisgene maps to 14q11.2 in a cluster of genes encoding other proteases. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CMA1_HUMAN, P23946Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellularmatrix degradation, and regulation of gland secretion
Gene Wiki entry for CMA1
|
Genomic Views
for CMA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CMA1 gene promoter:
HOXA9 HOXA9B ISGF-3 Spz1 RREB-1 Nkx2-2 C/EBPalpha STAT3 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CMA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12CMA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024974: view genomic region
(about GC identifiers)
Start:
|
24,974,559 bp from pter |
End:
|
24,977,471 bp from pter |
Size:
|
2,913 bases |
Orientation:
|
minus strand |
|
Proteins
for CMA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CMA1_HUMAN, P23946 (See
protein sequence)Recommended Name: Chymase precursor Size: 247 amino acids; 27325 Da
Subcellular location: Secreted. Cytoplasmic granule. Note=Mast cell granules
6/13 PDB 3D structures from  and Proteopedia  for CMA1 (see all 13):1KLT (3D)
1NN6 (3D)
1PJP (3D)
1T31 (3D)
2HVX (3D)
3N7O (3D)
Secondary accessions: B5BUM8 Q16018 Q3SY36 Q9UDH5Explore the universe of human proteins at neXtProt for CMA1: NX_P23946
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P23946
4/13 DME Specific Peptides for CMA1 (P23946) (see all 13)
CMA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001827.1
ENSEMBL proteins: ENSP00000250378 ENSP00000206446 Reactome Protein details: P23946
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005622 | intracellular |
IEA | -- | | GO:0031012 | colocalizes with extracellular matrix |
IDA | -- |
CMA1 for ontologies About GeneDecksing
CMA1 Antibody Products:
Assay Products for CMA1: |
Protein
Domains /
Families
for CMA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CMA1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P23946ProtoNet protein and cluster: P23946 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: CMA1_HUMAN, P23946Similarity: Belongs to the peptidase S1 family. Granzyme subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for CMA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CMA1_HUMAN, P23946Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellularmatrix degradation, and regulation of gland secretionCatalytic activity: Preferential cleavage: Phe- -Xaa > Tyr- -Xaa > Trp- -Xaa > Leu- -Xaa Genatlas biochemistry entry for CMA1:chymase,mast cell,with a variant putatively involved in eczema
Enzyme Numbers (IUBMB): EC 3.4.21.391 2 EC 3.4.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CMA1 (NM_001836) | |  | Sino Biological Human cDNA Clone for CMA1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CMA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMA1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CMA1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Cma1tm1Mfg for CMA1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cma1):
CMA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CMA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics | | | 2 | Degradation of the extracellular matrix | | | 3 | Renin-angiotensin system | | | 4 | PIP3 activates AKT signaling | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CMA1
1  BioSystems Pathway for CMA1
5/8 
Reactome Pathways for CMA1 (see all 8)
2  PharmGKB Pathways for CMA1
1 
Kegg Pathway (Kegg details for CMA1):
CMA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CMA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for CMA1 (P239463 ENSP000002503784) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
CMA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CMA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CMA1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CMA1 |
 Compounds for CMA1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| RETF-4NA | Selective chymase substrate | [1160928-63-1] |
2 HMDB Compounds for CMA1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Kinetensin 1-7 | Ile-Ala-Arg-Arg-His-Pro-Tyr;KT(1-7) | 34273-10-4 | -- | | Kinetensin 4-7 | Arg-His-Pro-Tyr;KT(4-7) | 34273-10-4 | -- |
5 DrugBank Compounds for CMA1 About this table
10/12 Novoseek chemical compound relationships for CMA1 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| scca1 |
86.7 |
5 |
10653592 (1), 14630915 (1), 12949073 (1), 9817977 (1) |
| chymostatin |
80.3 |
1 |
2266130 (1) |
| serine |
72 |
27 |
7867649 (1), 8913536 (1), 10653592 (1), 15163313 (1) (see all 27) |
| heparin |
41.1 |
3 |
2249356 (1), 9760188 (1), 8615699 (1) |
| histamine |
38.9 |
3 |
2249356 (1), 8095126 (1), 12234623 (1) |
| procollagen |
35.9 |
5 |
9054407 (3), 15703960 (1) |
| cysteine |
34 |
4 |
10653592 (1), 14630915 (1), 12949073 (1), 9817977 (1) |
| allergens |
5.4 |
1 |
15703960 (1) |
| capsaicin |
3.2 |
1 |
9508340 (1) |
| cholesterol |
1.42 |
7 |
10195937 (3), 9335947 (1), 12231569 (1), 12531890 (1) |
Search CenterWatch for drugs/clinical trials and news about CMA1
|
Transcripts
for CMA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CMA1 gene: NM_001836.3 Unigene Cluster for CMA1: Chymase 1, mast cell Hs.135626 [show with all ESTs]Unigene Representative Sequence: NM_0018362 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000250378(uc001wpp.1) ENST00000206446(uc010alx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CMA1 (NM_001836) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CMA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMA1 |
Additional cDNA sequence: AB451464.1 BC069110.1 BC069370.1 BC069490.1 BC103974.1 BC103975.1 DQ082727.1 DQ082729.1 M69136.1 S61334.1 1 DOTS entry: DT.75163377 8 AceView cDNA sequences: BC069370 NM_001836 AW291605 BC069110 BC069490 S61334 BX280474 M69136
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CMA1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | - | | | | | | | |
ECgene alternative splicing isoforms for CMA1
|
Expression
for CMA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CMA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCCCAGG
About this image
See CMA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CMA1
SOURCE GeneReport for Unigene cluster: Hs.135626
UniProtKB/Swiss-Prot: CMA1_HUMAN, P23946Tissue specificity: Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticariapigmentosa lesions
SABiosciences Expression via Pathway-Focused PCR Arrays including CMA1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CMA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMA1 |
Orthologs
for CMA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CMA1 gene from 2/15 species (see all 15) About this table
ENSEMBL Gene Tree for CMA1 (if available)
TreeFam Gene Tree for CMA1 (if available) |
Paralogs
for CMA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CMA1 gene
- PRTN32 GZMH2 GZMK2 PRSS572 CTSG2 CFD2 ELANE2 AZU12
- GZMM2 GZMB2 GZMA2
18/82 SIMAP similar genes for CMA1 using alignment to 4 protein entries: CMA1_HUMAN (see all proteins)
(see all similar genes):CTSG GZMB GZMH KLK8 GZMA PRTN3
KLK4 DF PRSS1 KLK7 CFD CTRB2
CTRB1 CFI GZMK PRSS3 ELANE KLK13
CMA1 for paralogs About GeneDecksing
|
Genomic Variants
for CMA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CMA1 (24974559 - 24977471 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CMA1: --
Human Gene Mutation Database (HGMD): CMA1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMA1 |
|
Disorders
/ Diseases
for CMA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CMA1 for disorders About GeneDecksing
OMIM gene information: 118938
OMIM disorders: --
20/54  diseases for CMA1 (see all 54): About MalaCardsalpha-1-antichymotrypsin deficiency hypertension open-angle glaucoma breast pericanalicular fibroadenoma
systolic heart failure abdominal aortic aneurysm vernal keratoconjunctivitis aortic aneurysm
idiopathic interstitial pneumonia neurogenic bladder crescentic glomerulonephritis keratoconjunctivitis
urticaria pigmentosa renovascular hypertension portal hypertension coronary heart disease
pulmonary fibrosis inflammatory bowel disease bronchial asthma hypertrophic cardiomyopathy
6 diseases from the University of Copenhagen DISEASES database for CMA1:Mastocytosis Asthma Dermatitis Heart disease
Rhinitis Atherosclerosis 10/17 Novoseek disease relationships for CMA1 gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| keratoconjunctivitis vernal |
58.9 |
1 |
15512949 (1) |
| dermatitis atopic |
49.5 |
12 |
16134991 (2), 15703960 (2), 10550754 (1), 15248847 (1) (see all 5) |
| mastocytoma |
45.1 |
4 |
1900681 (1), 8601622 (1) |
| dermatitis |
40.4 |
2 |
9257378 (1), 12234623 (1) |
| eczema |
39.3 |
5 |
15248847 (2), 15703960 (1), 9463800 (1), 8774571 (1) |
| inflammation |
32.2 |
10 |
11173969 (1), 15924217 (1), 9817978 (1), 15248847 (1) (see all 8) |
| vascular diseases |
30.6 |
1 |
10508822 (1) |
| asthma |
28.9 |
4 |
15248847 (3), 15924217 (1) |
| atopy |
28.6 |
1 |
16134991 (1) |
| asthma allergic |
24.4 |
5 |
15924217 (3) |
Genetic Association Database (GAD): CMA1
Human Genome Epidemiology (HuGE) Navigator: CMA1 (34 documents)
Export disorders for CMA1 gene to outside databases
|
Publications
for CMA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CMA1 gene, integrated from 9 sources (see all 217):
(articles sorted by number of sources associating them with CMA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis. (PubMed id 15248847)1, 4, 9 Iwanaga T....Holloway J.W. (2004)
- Association study of mast cell chymase polymorphisms with atopy. (PubMed id 16134991)1, 4, 9 Weidinger S....Illig T. (2005)
- A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels. (PubMed id 15924217)1, 4, 9 Sharma S....Ghosh B. (2005)
- Cloning of the gene and cDNA for human heart chymase. (PubMed id 1894611)1, 2, 9 Urata H.... Husain A. (1991)
- Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase. (PubMed id 2071582)1, 2, 9 Caughey G.H.... Vanderslice P. (1991)
- The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. (PubMed id 8468056)1, 3, 9 Caughey G.H....Ley T.J. (1993)
- A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril. (PubMed id 15788353)1, 4 He H....Hu Y.H. (2005)
- Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. (PubMed id 15914614)1, 4 Hashizume K....Miyaki K. (2005)
- [Association between angiotensin converting enzyme gene, chymase gene and regression of left ventricular hypertrophy in patients treated with angiotensin converting enzyme inhibitors.] (PubMed id 15555355)1, 4 He H....Hu Y.H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CMA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CMA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CMA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CMA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CMA1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CMA1 gene:
Search GeneIP for patents involving CMA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CMA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CMA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CMA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMA1 | | | OriGene Protein Over-expression Lysate for CMA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CMA1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CMA1 | | OriGene Custom Protein Services for CMA1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CMA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CMA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMA1 |
| |
 |  |  |  | |
| | | | Tocris compounds for CMA1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CMA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMA1 |
|  |  |  | | | | ThermoFisher Antibodies for CMA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMA1 |
|
|
|
|
