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Aliases for CLYBL Gene

Aliases for CLYBL Gene

  • Citrate Lyase Beta Like 2 3
  • CLB 3 4 6
  • Citrate Lyase Subunit Beta-Like Protein, Mitochondrial 3
  • Citrate Lyase Beta-Like 4
  • EC 4.1.-.- 4

External Ids for CLYBL Gene

Summaries for CLYBL Gene

GeneCards Summary for CLYBL Gene

CLYBL (Citrate Lyase Beta Like) is a Protein Coding gene. GO annotations related to this gene include citrate (pro-3S)-lyase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLYBL Gene

Genomics for CLYBL Gene

Genomic Location for CLYBL Gene

Start:
99,606,664 bp from pter
End:
99,909,459 bp from pter
Size:
302,796 bases
Orientation:
Plus strand

Genomic View for CLYBL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLYBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLYBL Gene

Regulatory Elements for CLYBL Gene

Proteins for CLYBL Gene

  • Protein details for CLYBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0X4-CLYBL_HUMAN
    Recommended name:
    Citrate lyase subunit beta-like protein, mitochondrial
    Protein Accession:
    Q8N0X4
    Secondary Accessions:
    • Q5W0F7
    • Q8TDH8

    Protein attributes for CLYBL Gene

    Size:
    340 amino acids
    Molecular mass:
    37359 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLYBL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLYBL Gene

Proteomics data for CLYBL Gene at MOPED

Post-translational modifications for CLYBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLYBL Gene

No data available for DME Specific Peptides for CLYBL Gene

Domains for CLYBL Gene

UniProtKB/Swiss-Prot:

CLYBL_HUMAN
Family:
  • Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.:
    • Q8N0X4
genes like me logo Genes that share domains with CLYBL: view

No data available for Gene Families for CLYBL Gene

Function for CLYBL Gene

Enzyme Numbers (IUBMB) for CLYBL Gene

Gene Ontology (GO) - Molecular Function for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLYBL: view

miRNA for CLYBL Gene

miRTarBase miRNAs that target CLYBL

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLYBL Gene

Localization for CLYBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLYBL Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLYBL Gene COMPARTMENTS Subcellular localization image for CLYBL gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CLYBL: view

Pathways for CLYBL Gene

SuperPathways for CLYBL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CLYBL: view

No data available for Pathways by source for CLYBL Gene

Compounds for CLYBL Gene

(3) HMDB Compounds for CLYBL Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
64-19-7
Citric acid
  • 2-Hydroxy-1,2,3-propanetricarboxylate
77-92-9
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with CLYBL: view

Transcripts for CLYBL Gene

Unigene Clusters for CLYBL Gene

Citrate lyase beta like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLYBL Gene

No ASD Table

Relevant External Links for CLYBL Gene

GeneLoc Exon Structure for
CLYBL
ECgene alternative splicing isoforms for
CLYBL

Expression for CLYBL Gene

mRNA expression in normal human tissues for CLYBL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLYBL Gene

This gene is overexpressed in Liver (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLYBL Gene

SOURCE GeneReport for Unigene cluster for CLYBL Gene Hs.655642

genes like me logo Genes that share expressions with CLYBL: view

Orthologs for CLYBL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLYBL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLYBL 36
  • 99.51 (n)
  • 99.41 (a)
CLYBL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLYBL 36
  • 82.59 (n)
  • 82.8 (a)
CLYBL 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLYBL 36
  • 89.51 (n)
  • 91.47 (a)
CLYBL 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clybl 36
  • 86.62 (n)
  • 89.64 (a)
Clybl 16
Clybl 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLYBL 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLYBL 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clybl 36
  • 86.22 (n)
  • 90.06 (a)
chicken
(Gallus gallus)
Aves CLYBL 36
  • 78.21 (n)
  • 80.13 (a)
CLYBL 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLYBL 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clybl 36
  • 72.82 (n)
  • 77.52 (a)
zebrafish
(Danio rerio)
Actinopterygii clybl 36
clybl 36
  • 67.2 (n)
  • 69.23 (a)
clybl 37
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C01G10.7 37
  • 45 (a)
OneToOne
CELE_C01G10.7 36
  • 52.01 (n)
  • 48.32 (a)
C01G10.7 38
  • 47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02734 36
  • 45.2 (n)
  • 33.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for CLYBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLYBL Gene

ENSEMBL:
Gene Tree for CLYBL (if available)
TreeFam:
Gene Tree for CLYBL (if available)

Paralogs for CLYBL Gene

Selected SIMAP similar genes for CLYBL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CLYBL: view

No data available for Paralogs for CLYBL Gene

Variants for CLYBL Gene

Sequence variations from dbSNP and Humsavar for CLYBL Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs869323 -- 99,606,248(+) ACATG(A/G)TGGGG upstream-variant-2KB
rs869324 -- 99,606,516(+) CGGGG(A/C)GGAGC upstream-variant-2KB
rs869325 -- 99,606,613(+) acggg(A/G)ggggg upstream-variant-2KB
rs912659 -- 99,606,956(-) GCAAC(A/G)AGGGC intron-variant
rs1107382 -- 99,636,029(-) TCTAC(A/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLYBL Gene

Variant ID Type Subtype PubMed ID
esv34003 CNV Loss 18971310
nsv832696 CNV Gain 17160897
esv2747875 CNV Deletion 23290073
nsv510360 CNV Loss 20534489
nsv821675 CNV Loss 15273396
esv2668346 CNV Deletion 23128226

Relevant External Links for CLYBL Gene

HapMap Linkage Disequilibrium report
CLYBL
Human Gene Mutation Database (HGMD)
CLYBL

Disorders for CLYBL Gene

Relevant External Links for CLYBL

Genetic Association Database (GAD)
CLYBL
Human Genome Epidemiology (HuGE) Navigator
CLYBL
genes like me logo Genes that share disorders with CLYBL: view

No data available for UniProtKB/Swiss-Prot for CLYBL Gene

Publications for CLYBL Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X. … Sun J. (Hum. Mol. Genet. 2012) 3 49
  4. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. (PMID: 11741334) Morikawa J. … Tanaka T. (Biochem. Biophys. Res. Commun. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLYBL Gene

Sources for CLYBL Gene

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