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CLYBL Gene

protein-coding   GIFtS: 52
GCID: GC13P100258

Citrate Lyase Beta Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Citrate Lyase Beta Like1 2
CLB2 3 5
Citrate Lyase Subunit Beta-Like Protein, Mitochondrial2
EC 4.1.-.-3
Citrate Lyase Beta-Like3

External Ids:    HGNC: 183551   Entrez Gene: 1714252   Ensembl: ENSG000001252467   OMIM: 6096865   UniProtKB: Q8N0X43   

Export aliases for CLYBL gene to outside databases

Previous GC identifers: GC13P098619 GC13P094646 GC13P099096 GC13P097956 GC13P099056 GC13P081019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLYBL Gene:
CLYBL (citrate lyase beta like) is a protein-coding gene. Diseases associated with CLYBL include dental fluorosis, and attention deficit hyperactivity disorder. GO annotations related to this gene include citrate (pro-3S)-lyase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLYBL gene promoter:
         TBP   C/EBPalpha   FOXC1   POU2F1   POU2F1a   POU2F1b   FOXO1a   SEF-1 (1)   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLYBL promoter sequence
   Search Chromatin IP Primers for CLYBL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLYBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

CLYBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLYBL gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P100258:  view genomic region     (about GC identifiers)

Start:
100,258,919 bp from pter      End:
100,549,388 bp from pter
Size:
290,470 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4 (See protein sequence)
Recommended Name: Citrate lyase subunit beta-like protein, mitochondrial precursor  
Size: 340 amino acids; 37359 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Caution: This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity.
Even though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat
different enzyme activity
Secondary accessions: Q5W0F7 Q8TDH8
Alternative splicing: 2 isoforms:  Q8N0X4-1   Q8N0X4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLYBL: NX_Q8N0X4

Explore proteomics data for CLYBL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLYBL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996531.1  
    ENSEMBL proteins: 
     ENSP00000365538   ENSP00000365532   ENSP00000342991   ENSP00000403408   ENSP00000401586  
     ENSP00000396574   ENSP00000389062   ENSP00000365533   ENSP00000404768  

    CLYBL Human Recombinant Protein Products:

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    Novus Biologicals CLYBL Protein
    Novus Biologicals CLYBL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CLYBL Antibody Products:

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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CLYBL
    Search LSBio for Antibodies for CLYBL

    CLYBL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011206 Citrate_lyase_beta
     IPR005000 Aldehyde-lyase_domain
     IPR015813 Pyrv/PenolPyrv_Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N0X4

    ProtoNet protein and cluster: Q8N0X4

    1 Blocks protein domain: IPB011076 Malate synthase-like

    UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4
    Similarity: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily


    CLYBL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 4.1.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008815citrate (pro-3S)-lyase activity IEA--
    GO:0016830carbon-carbon lyase activity ----
    GO:0046872metal ion binding IEA--
         
    CLYBL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLYBL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLYBL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLYBL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLYBL

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLYBL:
    hsa-mir-769-5p (MIRT039139)

    Block miRNA regulation of human, mouse, rat CLYBL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CLYBL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLYBL

    Clone
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    OriGene clones in human, mouse for CLYBL (see all 8)
    OriGene ORF clones in mouse, rat for CLYBL
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    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    Sino Biological Human cDNA Clone for CLYBL
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CLYBL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLYBL_HUMAN, Q8N0X4: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0009346citrate lyase complex IEA--

    CLYBL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLYBL
    Interactions:

        Search GeneGlobe Interaction Network for CLYBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CLYBL (Q8N0X43 ENSP000003655384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B973, ENSP000003809214I2D: score=1 STRING: ENSP00000380921
    INPP5DQ928353, ENSP000003525754I2D: score=1 STRING: ENSP00000352575
    LATO435613, ENSP000003541194I2D: score=1 STRING: ENSP00000354119
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ACLYENSP000002537924STRING: ENSP00000253792
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006725cellular aromatic compound metabolic process IEA--

    CLYBL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLYBL

    3 HMDB Compounds for CLYBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLYBL gene: 
    NM_206808.3  

    Unigene Cluster for CLYBL:

    Citrate lyase beta like
    Hs.655642  [show with all ESTs]
    Unigene Representative Sequence: NM_206808
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376360(uc010tix.2) ENST00000376354 ENST00000339105 ENST00000416504
    ENST00000443887 ENST00000419700 ENST00000425186 ENST00000376355(uc001vok.3)
    ENST00000444838(uc010tiy.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLYBL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLYBL
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    OriGene clones in human, mouse for CLYBL (see all 8)
    OriGene ORF clones in mouse, rat for CLYBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLYBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLYBL
    OriGene qSTAR qPCR primer pairs in human, mouse for CLYBL
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CLYBL
      QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
      QuantiFast Probe-based Assays in human, mouse, rat CLYBL

    Additional mRNA sequence: 

    AF428253.1 AK300510.1 BC034360.1 

    13 DOTS entries:

    DT.75101079  DT.438382  DT.75157672  DT.100023065  DT.92417257  DT.86852608  DT.95151386  DT.95154927 
    DT.99979457  DT.86846091  DT.95113268  DT.100667334  DT.91858859 

    Selected AceView cDNA sequences (see all 58):

    AI609021 BG568175 C21177 BM053009 CK903940 NM_138280 BC034360 BM052993 
    NM_206808 BM979352 BG399471 BE790239 AW205708 AI478544 AI379577 BM795622 
    BM052726 W39248 AI478489 BE222003 AI476268 CK903939 CA429253 BI830300 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLYBL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTTTTGTG
    CLYBL Expression
    About this image


    CLYBL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Diencephalic Roof Plate
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Secondary Oocyte Antral Follicle
    CLYBL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLYBL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655642
        Custom PCR Arrays for CLYBL
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CLYBL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLYBL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clybl1 , 5 citrate lyase beta like1, 5 86.62(n)1
    89.64(a)1
      14 (65.86 cM)5
    696341  NM_029556.31  NP_083832.21 
     1221816945 
    chicken
    (Gallus gallus)
    Aves CLYBL1 citrate lyase beta like 78.21(n)
    80.13(a)
      418775  XM_416971.3  XP_416971.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLYBL6
    citrate lyase beta like
    71(a)
    1 ↔ 1
    3(98943234-99171613)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clybl1 citrate lyase beta like 72.82(n)
    77.52(a)
      101731346  XM_004911819.1  XP_004911876.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clybl2 citrate lyase beta-like 76.32(n)   368236  CF997552.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01G10.73
    CELE_C01G10.71
    citrate lyase beta chain3
    CELE_C01G10.71
    47(a)3
    52.01(n)1
    48.32(a)1
      V(15088346-15089422)3
    1800181  NM_074315.51  NP_506716.11 


    ENSEMBL Gene Tree for CLYBL (if available)
    TreeFam Gene Tree for CLYBL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLYBL gene
    3 SIMAP similar genes for CLYBL using alignment to 6 protein entries:     CLYBL_HUMAN (see all proteins):
    AURA2    NF2    YTHDF3

    CLYBL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLYBL (see all 6115)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354498221,2
    C--80909465(+) AAAAC-/T/T   
       T
    /TTT
    TTTTT
    2 -- int1 cds11CSA 2
    rs791038661,2
    C--81030553(+) CTTTG-/ATTA  
     AACTTTG
    GGACA
    1 -- int10--------
    rs1459911341,2
    --100256920(+) AGCGAC/TGCAAT 1 -- us2k10--------
    rs747395611,2
    C,F--100257043(+) GGTGAT/GGAGGT 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1399740561,2
    --100257044(+) GTGATA/GAGGTA 1 -- us2k10--------
    rs1868061931,2
    --100257180(+) CAAACA/GGGTGA 1 -- us2k10--------
    rs1909764731,2
    --100257325(+) ATTACC/TGCACT 1 -- us2k10--------
    rs352154551,2
    C--100257365(+) CTCAG-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs95823281,2
    C,F,A--100257405(+) ctggcA/Gtggtg 1 -- us2k16Minor allele frequency- G:0.09NA WA 246
    rs1497339301,2
    C--100257421(+) TGCCTA/GTAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLYBL (100258919 - 100508919 bp, first 250kb of CLYBL)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLYBL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668346CNV Deletion23128226
    esv2747875CNV Deletion23290073
    nsv821675CNV Loss15273396
    nsv510360CNV Loss20534489
    esv34003CNV Loss18971310
    nsv832696CNV Gain17160897

    Human Gene Mutation Database (HGMD): CLYBL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLYBL
    DNA2.0 Custom Variant and Variant Library Synthesis for CLYBL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609686    OMIM disorders: --

    10 diseases for CLYBL:    
    About MalaCards
    dental fluorosis    attention deficit hyperactivity disorder    choroiditis    tuberculosis
    tonsillitis    obesity    thyroiditis    cerebritis
    endotheliitis    prostatitis


    CLYBL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLYBL
    Human Genome Epidemiology (HuGE) Navigator: CLYBL (3 documents)

    Export disorders for CLYBL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLYBL gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CLYBL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1, 4 Lin X....Sun J. (Hum. Mol. Genet. 2012)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. (PubMed id 11741334)1, 2 Morikawa J.... Tanaka T. (Biochem. Biophys. Res. Commun. 2001)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. (PubMed id 20304029)1 Ruschmann J....Krystal G. (Exp. Hematol. 2010)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 171425 HGNC: 18355 AceView: CLYBL Ensembl:ENSG00000125246 euGenes: HUgn171425
    ECgene: CLYBL H-InvDB: CLYBL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLYBL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLYBL gene:
    Search GeneIP for patents involving CLYBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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