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Aliases for CLYBL Gene

Aliases for CLYBL Gene

  • Citrate Lyase Beta Like 2 3
  • CLB 3 4 6
  • Citrate Lyase Subunit Beta-Like Protein, Mitochondrial 3
  • Citrate Lyase Beta-Like 4
  • EC 4.1.-.- 4

External Ids for CLYBL Gene

Previous GeneCards Identifiers for CLYBL Gene

  • GC13P098619
  • GC13P094646
  • GC13P099096
  • GC13P097956
  • GC13P099056
  • GC13P100258
  • GC13P081019

Summaries for CLYBL Gene

GeneCards Summary for CLYBL Gene

CLYBL (Citrate Lyase Beta Like) is a Protein Coding gene. GO annotations related to this gene include citrate (pro-3S)-lyase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLYBL Gene

Genomics for CLYBL Gene

Regulatory Elements for CLYBL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLYBL Gene

99,606,664 bp from pter
99,909,459 bp from pter
302,796 bases
Plus strand

Genomic View for CLYBL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLYBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLYBL Gene

Proteins for CLYBL Gene

  • Protein details for CLYBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Citrate lyase subunit beta-like protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5W0F7
    • Q8TDH8

    Protein attributes for CLYBL Gene

    340 amino acids
    Molecular mass:
    37359 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLYBL Gene


neXtProt entry for CLYBL Gene

Proteomics data for CLYBL Gene at MOPED

Post-translational modifications for CLYBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLYBL Gene

No data available for DME Specific Peptides for CLYBL Gene

Domains for CLYBL Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N0X4
  • Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.
genes like me logo Genes that share domains with CLYBL: view

No data available for Gene Families for CLYBL Gene

Function for CLYBL Gene

Enzyme Numbers (IUBMB) for CLYBL Gene

Gene Ontology (GO) - Molecular Function for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CLYBL: view

Animal Model Products

miRNA for CLYBL Gene

miRTarBase miRNAs that target CLYBL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLYBL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLYBL Gene

Localization for CLYBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLYBL Gene


Subcellular locations from

Jensen Localization Image for CLYBL Gene COMPARTMENTS Subcellular localization image for CLYBL gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CLYBL: view

Pathways for CLYBL Gene

SuperPathways for CLYBL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLYBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CLYBL: view

No data available for Pathways by source for CLYBL Gene

Compounds for CLYBL Gene

(3) HMDB Compounds for CLYBL Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
Citric acid
  • 2-Hydroxy-1,2,3-propanetricarboxylate
  • Magnesium
genes like me logo Genes that share compounds with CLYBL: view

Transcripts for CLYBL Gene

Unigene Clusters for CLYBL Gene

Citrate lyase beta like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLYBL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLYBL Gene

No ASD Table

Relevant External Links for CLYBL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLYBL Gene

mRNA expression in normal human tissues for CLYBL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLYBL Gene

This gene is overexpressed in Liver (5.0).

Protein differential expression in normal tissues for CLYBL Gene

This gene is overexpressed in Liver, secretome (29.2) and Liver (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLYBL Gene

SOURCE GeneReport for Unigene cluster for CLYBL Gene Hs.655642

genes like me logo Genes that share expressions with CLYBL: view

Expression partners for CLYBL Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CLYBL Gene

Orthologs for CLYBL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLYBL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLYBL 35
  • 82.59 (n)
  • 82.8 (a)
  • 90 (a)
(Canis familiaris)
Mammalia CLYBL 35
  • 89.51 (n)
  • 91.47 (a)
  • 89 (a)
(Mus musculus)
Mammalia Clybl 35
  • 86.62 (n)
  • 89.64 (a)
Clybl 16
Clybl 36
  • 86 (a)
(Pan troglodytes)
Mammalia CLYBL 35
  • 99.51 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Clybl 35
  • 86.22 (n)
  • 90.06 (a)
(Monodelphis domestica)
Mammalia CLYBL 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CLYBL 36
  • 79 (a)
(Gallus gallus)
Aves CLYBL 35
  • 78.21 (n)
  • 80.13 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia CLYBL 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clybl 35
  • 72.82 (n)
  • 77.52 (a)
(Danio rerio)
Actinopterygii clybl 35
clybl 35
  • 67.2 (n)
  • 69.23 (a)
clybl 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea C01G10.7 37
  • 47 (a)
CELE_C01G10.7 35
  • 52.01 (n)
  • 48.32 (a)
C01G10.7 36
  • 45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02734 35
  • 45.2 (n)
  • 33.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for CLYBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLYBL Gene

Gene Tree for CLYBL (if available)
Gene Tree for CLYBL (if available)

Paralogs for CLYBL Gene

Selected SIMAP similar genes for CLYBL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CLYBL: view

No data available for Paralogs for CLYBL Gene

Variants for CLYBL Gene

Sequence variations from dbSNP and Humsavar for CLYBL Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs869323 -- 99,606,248(+) ACATG(A/G)TGGGG upstream-variant-2KB
rs869324 -- 99,606,516(+) CGGGG(A/C)GGAGC upstream-variant-2KB
rs869325 -- 99,606,613(+) acggg(A/G)ggggg upstream-variant-2KB
rs912659 -- 99,606,956(-) GCAAC(A/G)AGGGC intron-variant
rs1107382 -- 99,636,029(-) TCTAC(A/T)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLYBL Gene

Variant ID Type Subtype PubMed ID
esv34003 CNV Loss 18971310
nsv832696 CNV Gain 17160897
esv2747875 CNV Deletion 23290073
nsv510360 CNV Loss 20534489
nsv821675 CNV Loss 15273396
esv2668346 CNV Deletion 23128226

Relevant External Links for CLYBL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLYBL Gene

Disorders for CLYBL Gene

Relevant External Links for CLYBL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CLYBL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLYBL Gene

Publications for CLYBL Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X. … Sun J. (Hum. Mol. Genet. 2012) 3 48
  4. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. (PMID: 11741334) Morikawa J. … Tanaka T. (Biochem. Biophys. Res. Commun. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLYBL Gene

Sources for CLYBL Gene

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