Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLYBL Gene

protein-coding   GIFtS: 50
GCID: GC13P100258

citrate lyase beta like
 Explore 4 diseases affiliated with
CLYBL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLYBL    

Aliases
for CLYBL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Citrate Lyase Beta Like1 2
CLB1 2 3 5
Citrate Lyase Beta-Like2 3
BA134O15.11
Citrate Lyase Subunit Beta-Like Protein, Mitochondrial2
EC 4.1.-.-3

External Ids:    HGNC: 183551   Entrez Gene: 1714252   Ensembl: ENSG000001252467   OMIM: 6096865   UniProtKB: Q8N0X43   

Export aliases for CLYBL gene to outside databases

Previous GC identifers: GC13P098619 GC13P094646 GC13P099096 GC13P097956 GC13P099056 GC13P081019


Summaries
for CLYBL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CLYBL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLYBL gene promoter:
         TBP   C/EBPalpha   FOXC1   POU2F1   POU2F1a   POU2F1b   FOXO1a   SEF-1 (1)   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLYBL promoter sequence
   Search SABiosciences Chromatin IP Primers for CLYBL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLYBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

CLYBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLYBL gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P100258:  view genomic region     (about GC identifiers)

Start:
 100,258,919 bp from pter      End:
 100,549,388 bp from pter
Size:
 290,470 bases      Orientation:
 plus strand

Proteins
for CLYBL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4 (See protein sequence)
Recommended Name: Citrate lyase subunit beta-like protein, mitochondrial precursor  
Size: 340 amino acids; 37359 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subcellular location: Mitochondrion (Potential)
Caution: This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity. Even
though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat different
enzyme activity
Secondary accessions: Q5W0F7 Q8TDH8
Alternative splicing: 2 isoforms:  Q8N0X4-1   Q8N0X4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLYBL: NX_Q8N0X4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N0X4

    • CLYBL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_996531.1  
    ENSEMBL proteins: 
     ENSP00000365538   ENSP00000365532   ENSP00000342991   ENSP00000403408   ENSP00000401586  
     ENSP00000396574   ENSP00000389062   ENSP00000365533   ENSP00000404768  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CLYBL
    OriGene Protein Over-expression Lysate: CLYBL
    OriGene Custom Protein Services for CLYBL 
    GenScript Custom Purified and Recombinant Proteins Services for CLYBL
    Novus Biologicals CLYBL Protein
    Novus Biologicals CLYBL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0009346citrate lyase complex IEA--


    CLYBL for ontologies           About GeneDecksing



    CLYBL Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLYBL 
    GenScript Custom Superior Antibodies Services for CLYBL
    Novus Biologicals CLYBL Antibodies
    Search for Antibodies for CLYBL at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibody for CLYBL

    Assay Products for CLYBL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLYBL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CLYBL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLYBL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011206 Citrate_lyase_beta
     IPR005000 Aldehyde-lyase_domain
     IPR015813 Pyrv/PenolPyrv_Kinase

    Graphical View of Domain Structure for InterPro Entry Q8N0X4

    ProtoNet protein and cluster: Q8N0X4

    1 Blocks protein family: IPB011076 Malate synthase-like

    UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4
    Similarity: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily


    Function
    for CLYBL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Enzyme Number (IUBMB): EC 4.1.-.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CLYBL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLYBL
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLYBL (see all 7)
    OriGene shRNA RFP: CLYBL
    OriGene siRNA: CLYBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLYBL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLYBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CLYBL
    Search LifeMap BioReagents cell lines for CLYBL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008815citrate (pro-3S)-lyase activity IEA--
    GO:0016829lyase activity ----
    GO:0016830carbon-carbon lyase activity ----
    GO:0046872metal ion binding IEA--


    CLYBL for ontologies           About GeneDecksing



    Pathways & Interactions
    for CLYBL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLYBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CLYBL (Q8N0X43 ENSP000003655384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B973, ENSP000003809214I2D: score=1 STRING: ENSP00000380921
    INPP5DQ928353, ENSP000003525754I2D: score=1 STRING: ENSP00000352575
    LATO435613, ENSP000003541194I2D: score=1 STRING: ENSP00000354119
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ACLYENSP000002537924STRING: ENSP00000253792
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006725cellular aromatic compound metabolic process IEA--


    CLYBL for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLYBL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLYBL

    3 HMDB Compounds for CLYBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about CLYBL 

    Transcripts
    for CLYBL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLYBL gene (2 alternative transcripts): 
    NM_138280.3  NM_206808.2  

    Unigene Cluster for CLYBL:

    Citrate lyase beta like
    Hs.655642  [show with all ESTs]
    Unigene Representative Sequence: NM_206808
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376360(uc010tix.2) ENST00000376354 ENST00000339105 ENST00000416504
    ENST00000443887 ENST00000419700 ENST00000425186 ENST00000376355(uc001vok.3)
    ENST00000444838(uc010tiy.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLYBL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLYBL
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLYBL (see all 7)
    OriGene shRNA RFP: CLYBL
    OriGene siRNA: CLYBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLYBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLYBL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLYBL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL

    Additional cDNA sequence: 

    AF428253.1 AK300510.1 BC034360.1 

    13 DOTS entries:

    DT.75101079  DT.438382  DT.75157672  DT.100023065  DT.92417257  DT.86852608  DT.95151386  DT.95154927 
    DT.99979457  DT.86846091  DT.95113268  DT.100667334  DT.91858859 

    24/58 AceView cDNA sequences (see all 58):

    C21177 AI609021 BC034360 BG568175 NM_206808 BM053009 BM979352 CK903940 
    BM052993 NM_138280 BI830300 CA429253 AK095506 AW854183 AA721678 BG399471 
    AW205708 W39248 BM987829 BE790239 BG677695 BG504693 BM982707 BM795622 

    GeneLoc Exon Structure


    Expression
    for CLYBL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLYBL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTTTTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLYBL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    BrainChoroid PlexusBrain
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLYBL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLYBL

    SOURCE GeneReport for Unigene cluster: Hs.655642
        SABiosciences Custom PCR Arrays for CLYBL
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLYBL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLYBL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL

    Orthologs
    for CLYBL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CLYBL gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clybl1 , 5 citrate lyase beta like1, 5 84.71(n)1
    86.09(a)1    		   14 (65.86 cM)5
    696341  NM_029556.31  NP_083832.21 
     1221816945 
    chicken
    (Gallus gallus)    		 Aves CLYBL1 citrate lyase beta like 76.46(n)
    77.88(a)    		   418775  XM_416971.2  XP_416971.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CLYBL6
    		 --
    		 80(a)
    		 1 ↔ 1
    		 3(99135540-99167286)
    zebrafish
    (Danio rerio)    		 Actinopterygii clybl2 citrate lyase beta-like 76.32(n)   368236  CF997552.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C01G10.73
    CELE_C01G10.71    		 citrate lyase beta chain3
    Protein C01G10.71    		 47(a)3
    52.01(n)1
    48.32(a)1    		   V(15088346-15089422)3
    1800181  NM_074315.41  NP_506716.11 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria citE6
    		 citrate lyase, citryl-ACP lyase (beta) subunit
    		 24(a)
    		 1 ↔ 1
    		 Chromosome(648805-649713)


    ENSEMBL Gene Tree for CLYBL (if available)
    TreeFam Gene Tree for CLYBL (if available) 

    Paralogs
    for CLYBL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CLYBL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5307 NCBI SNPs in CLYBL are shown (see all 5307)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1459911341,2
    		--100256920(+) AGCGAC/TGCAAT 1 -- us2k10--------
    rs747395611,2
    		C,F,--100257043(+) GGTGAT/GGAGGT 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1399740561,2
    		--100257044(+) GTGATA/GAGGTA 1 -- us2k10--------
    rs1868061931,2
    		--100257180(+) CAAACA/GGGTGA 1 -- us2k10--------
    rs1909764731,2
    		--100257325(+) ATTACC/TGCACT 1 -- us2k10--------
    rs352154551,2
    		C--100257365(+) CTCAG-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs95823281,2
    		C,F,A,--100257405(+) ctggcA/Gtggtg 1 -- us2k16Minor allele frequency- G:0.09NA WA 246
    rs1497339301,2
    		--100257421(+) TGCCTA/GTAAGC 1 -- us2k10--------
    rs619738331,2
    		C,F,--100257447(+) GCTGAG/CGCGGA 1 -- us2k13Minor allele frequency- C:0.33NA WA 6
    rs1484146821,2
    		--100257450(+) GACGCA/GGATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLYBL (100258919 - 100508919 bp, first 250kb of CLYBL)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CLYBL
         2 CNVs: 0315 48033
    Human Gene Mutation Database (HGMD): CLYBL

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLYBL
    DNA2.0 Custom Variant and Variant Library Synthesis for CLYBL

    Disorders / Diseases
    for CLYBL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLYBL for disorders           About GeneDecksing

    OMIM gene information: 609686    OMIM disorders: --

    4 diseases for CLYBL:    About MalaCards
    attention deficit hyperactivity disorder    dental fluorosis    tuberculosis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: CLYBL (3 documents)

    Export disorders for CLYBL gene to outside databases

    Publications
    for CLYBL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLYBL gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CLYBL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. (PubMed id 11741334)1, 2 Morikawa J.... Tanaka T. (2001)
    3. Genome-wide association study identifies novel loci as sociated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1 Lin X....Sun J. (2012)
    4. Tyrosine phosphorylation of SHIP promotes its proteas omal degradation. (PubMed id 20304029)1 Ruschmann J....Krystal G. (2010)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    7. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1 Lasky-Su J....Faraone S.V. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for CLYBL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLYBL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 171425 HGNC: 18355 AceView: CLYBL Ensembl:ENSG00000125246 euGenes: HUgn171425
    ECgene: CLYBL H-InvDB: CLYBL

    Other Databases showing CLYBL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLYBL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLYBL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLYBL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLYBL gene:
    Search GeneIP for patents involving CLYBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLYBL gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CLYBL  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLYBL   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLYBL  
     OriGene Protein Over-expression Lysate for CLYBL   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CLYBL   OriGene 3'-UTR Clone for CLYBL  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLYBL  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CLYBL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLYBL   OriGene Custom Protein Services for CLYBL  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLYBL
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLYBL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLYBL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
     GenScript Custom Purified and Recombinant Proteins Services for CLYBL GenScript cDNA clones with any tag delivered in your preferred vector for CLYBL
     GenScript Custom Assay Services for CLYBL GenScript Custom Superior Antibodies Services for CLYBL
     GenScript Custom overexpressing Cell Line Services for CLYBL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLYBL promoter
     Search Chromatin IP Primers for CLYBL
     RT2 qPCR Primer Assay in human, mouse / rat CLYBL
     Search GNC Networks for CLYBL
     SABiosciences Custom PCR Arrays for CLYBL
     Search Tocris compounds for CLYBL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLYBL antibodies
     CLYBL proteins
     CLYBL lysates
     Search for Antibodies for CLYBL at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CLYBL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CLYBL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CLYBL
     SwitchGear Promoter luciferase reporter plasmids for CLYBL
     ThermoFisher Antibody for CLYBL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CLYBL gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4