Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLYBL Gene

protein-coding   GIFtS: 52
GCID: GC13P100258

Citrate Lyase Beta Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Citrate Lyase Beta Like1 2
CLB2 3 5
Citrate Lyase Beta-Like2 3
bA134O15.12
Citrate Lyase Subunit Beta-Like Protein, Mitochondrial2
EC 4.1.-.-3

External Ids:    HGNC: 183551   Entrez Gene: 1714252   Ensembl: ENSG000001252467   OMIM: 6096865   UniProtKB: Q8N0X43   

Export aliases for CLYBL gene to outside databases

Previous GC identifers: GC13P098619 GC13P094646 GC13P099096 GC13P097956 GC13P099056 GC13P081019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLYBL Gene: 
CLYBL (citrate lyase beta like) is a protein-coding gene. Diseases associated with CLYBL include dental fluorosis, and attention deficit hyperactivity disorder. GO annotations related to this gene include citrate (pro-3S)-lyase activity and metal ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLYBL gene promoter:
         TBP   C/EBPalpha   FOXC1   POU2F1   POU2F1a   POU2F1b   FOXO1a   SEF-1 (1)   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLYBL promoter sequence
   Search SABiosciences Chromatin IP Primers for CLYBL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLYBL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

CLYBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLYBL gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P100258:  view genomic region     (about GC identifiers)

Start:
100,258,919 bp from pter      End:
100,549,388 bp from pter
Size:
290,470 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4 (See protein sequence)
Recommended Name: Citrate lyase subunit beta-like protein, mitochondrial precursor  
Size: 340 amino acids; 37359 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subcellular location: Mitochondrion (Potential)
Caution: This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity.
Even though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat
different enzyme activity
Secondary accessions: Q5W0F7 Q8TDH8
Alternative splicing: 2 isoforms:  Q8N0X4-1   Q8N0X4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLYBL: NX_Q8N0X4

Explore proteomics data for CLYBL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N0X4

  • CLYBL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLYBL Protein Expression
    REFSEQ proteins: NP_996531.1  
    ENSEMBL proteins: 
     ENSP00000365538   ENSP00000365532   ENSP00000342991   ENSP00000403408   ENSP00000401586  
     ENSP00000396574   ENSP00000389062   ENSP00000365533   ENSP00000404768  

    Human Recombinant Protein Products for CLYBL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CLYBL
    OriGene Protein Over-expression Lysate for CLYBL
    OriGene MassSpec for CLYBL 
    OriGene Custom Protein Services for CLYBL
    GenScript Custom Purified and Recombinant Proteins Services for CLYBL
    Novus Biologicals CLYBL Protein
    Novus Biologicals CLYBL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0009346citrate lyase complex IEA--

    CLYBL for ontologies           About GeneDecksing



    CLYBL Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLYBL
    GenScript Custom Superior Antibodies Services for CLYBL
    Novus Biologicals CLYBL Antibodies
    Abcam antibodies for CLYBL
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CLYBL
    Search LSBio for Antibodies for CLYBL 

    Assay Products for CLYBL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLYBL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLYBL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011206 Citrate_lyase_beta
     IPR005000 Aldehyde-lyase_domain
     IPR015813 Pyrv/PenolPyrv_Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N0X4

    ProtoNet protein and cluster: Q8N0X4

    1 Blocks protein domain: IPB011076 Malate synthase-like

    UniProtKB/Swiss-Prot: CLYBL_HUMAN, Q8N0X4
    Similarity: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily


    CLYBL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 4.1.-.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008815citrate (pro-3S)-lyase activity IEA--
    GO:0016830carbon-carbon lyase activity ----
    GO:0046872metal ion binding IEA--
         
    CLYBL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLYBL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLYBL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLYBL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLYBL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLYBL
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLYBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLYBL
    Sirion Biotech Customized adenovirus for overexpression of CLYBL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLYBL (see all 8)
    OriGene ORF clones in mouse, rat for CLYBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    Sino Biological Human cDNA Clone for CLYBL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLYBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL
    Sirion Biotech Customized lentivirus for stable overexpression of CLYBL 
                         Customized lentivirus expression plasmids for stable overexpression of CLYBL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLYBL
    Search LifeMap BioReagents cell lines for CLYBL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLYBL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CLYBL (Q8N0X43 ENSP000003655384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B973, ENSP000003809214I2D: score=1 STRING: ENSP00000380921
    INPP5DQ928353, ENSP000003525754I2D: score=1 STRING: ENSP00000352575
    LATO435613, ENSP000003541194I2D: score=1 STRING: ENSP00000354119
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ACLYENSP000002537924STRING: ENSP00000253792
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006725cellular aromatic compound metabolic process IEA--

    CLYBL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLYBL

    3 HMDB Compounds for CLYBL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about CLYBL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLYBL gene (2 alternative transcripts): 
    NM_138280.3  NM_206808.2  

    Unigene Cluster for CLYBL:

    Citrate lyase beta like
    Hs.655642  [show with all ESTs]
    Unigene Representative Sequence: NM_206808
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376360(uc010tix.2) ENST00000376354 ENST00000339105 ENST00000416504
    ENST00000443887 ENST00000419700 ENST00000425186 ENST00000376355(uc001vok.3)
    ENST00000444838(uc010tiy.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLYBL
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate CLYBL (see all 88):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-607 hsa-miR-640 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-3921 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLYBL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL
    Clone
    Products:
         
    OriGene clones in human, mouse for CLYBL (see all 8)
    OriGene ORF clones in mouse, rat for CLYBL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLYBL (NM_206808)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLYBL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL
    Sirion Biotech Customized lentivirus for stable overexpression of CLYBL 
                         Customized lentivirus expression plasmids for stable overexpression of CLYBL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLYBL
    OriGene qSTAR qPCR primer pairs in human, mouse for CLYBL
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLYBL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL

    Additional mRNA sequence: 

    AF428253.1 AK300510.1 BC034360.1 

    13 DOTS entries:

    DT.75101079  DT.438382  DT.75157672  DT.100023065  DT.92417257  DT.86852608  DT.95151386  DT.95154927 
    DT.99979457  DT.86846091  DT.95113268  DT.100667334  DT.91858859 

    24/58 AceView cDNA sequences (see all 58):

    BC034360 NM_138280 BM052993 BM979352 CK903940 BM053009 C21177 AI609021 
    BG568175 NM_206808 AI949665 BG399471 BM987829 BE222003 BM795622 CA429253 
    AA721678 BG504693 AW205708 AI478544 BM971638 CK903939 AI478489 BX090926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLYBL expression in normal human tissues (normalized intensities)      CLYBL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTTTTGTG
    CLYBL Expression
    About this image


    CLYBL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             brain/midbrain/lateral wall   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Diencephalic Roof Plate
             brain/midbrain/lateral wall   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CLYBL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLYBL

    SOURCE GeneReport for Unigene cluster: Hs.655642
        SABiosciences Custom PCR Arrays for CLYBL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLYBL
    OriGene qSTAR qPCR primer pairs in human, mouse for CLYBL
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLYBL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CLYBL gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clybl1 , 5 citrate lyase beta like1, 5 84.71(n)1
    86.09(a)1
      14 (65.86 cM)5
    696341  NM_029556.31  NP_083832.21 
     1221816945 
    chicken
    (Gallus gallus)
    Aves CLYBL1 citrate lyase beta like 76.46(n)
    77.88(a)
      418775  XM_416971.2  XP_416971.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLYBL6
    Uncharacterized protein
    71(a)
    1 ↔ 1
    3(98943234-99171613)
    zebrafish
    (Danio rerio)
    Actinopterygii clybl2 citrate lyase beta-like 76.32(n)   368236  CF997552.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01G10.73
    CELE_C01G10.71
    citrate lyase beta chain3
    Protein C01G10.71
    47(a)3
    52.01(n)1
    48.32(a)1
      V(15088346-15089422)3
    1800181  NM_074315.41  NP_506716.11 


    ENSEMBL Gene Tree for CLYBL (if available)
    TreeFam Gene Tree for CLYBL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLYBL gene
    2 SIMAP similar genes for CLYBL using alignment to 6 protein entries:     CLYBL_HUMAN (see all proteins):
    AURA2    NF2

    CLYBL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6115 SNPs in CLYBL are shown (see all 6115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354498221,2
    C--80909465(+) AAAAC-/T/T   
       T
    /TTT
    TTTTT
    2 -- int1 cds11CSA 2
    rs791038661,2
    C--81030553(+) CTTTG-/ATTA  
     AACTTTG
    GGACA
    1 -- int10--------
    rs1459911341,2
    --100256920(+) AGCGAC/TGCAAT 1 -- us2k10--------
    rs747395611,2
    C,F--100257043(+) GGTGAT/GGAGGT 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs1399740561,2
    --100257044(+) GTGATA/GAGGTA 1 -- us2k10--------
    rs1868061931,2
    --100257180(+) CAAACA/GGGTGA 1 -- us2k10--------
    rs1909764731,2
    --100257325(+) ATTACC/TGCACT 1 -- us2k10--------
    rs352154551,2
    C--100257365(+) CTCAG-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs95823281,2
    C,F,A--100257405(+) ctggcA/Gtggtg 1 -- us2k16Minor allele frequency- G:0.09NA WA 246
    rs1497339301,2
    C--100257421(+) TGCCTA/GTAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLYBL (100258919 - 100508919 bp, first 250kb of CLYBL)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLYBL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668346CNV Deletion23128226
    esv2747875CNV Deletion23290073
    nsv821675CNV Loss15273396
    nsv510360CNV Loss20534489
    esv34003CNV Loss18971310
    nsv832696CNV Gain17160897


    Human Gene Mutation Database (HGMD): CLYBL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLYBL
    DNA2.0 Custom Variant and Variant Library Synthesis for CLYBL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609686    OMIM disorders: --

    3 diseases for CLYBL:    About MalaCards
    dental fluorosis    attention deficit hyperactivity disorder    tuberculosis


    CLYBL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLYBL
    Human Genome Epidemiology (HuGE) Navigator: CLYBL (3 documents)

    Export disorders for CLYBL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLYBL gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CLYBL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies novel loci as sociated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1, 4 Lin X....Sun J. (2012)
    2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. (PubMed id 11741334)1, 2 Morikawa J.... Tanaka T. (2001)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    8. Tyrosine phosphorylation of SHIP promotes its proteas omal degradation. (PubMed id 20304029)1 Ruschmann J....Krystal G. (2010)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 171425 HGNC: 18355 AceView: CLYBL Ensembl:ENSG00000125246 euGenes: HUgn171425
    ECgene: CLYBL H-InvDB: CLYBL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLYBL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLYBL gene:
    Search GeneIP for patents involving CLYBL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLYBL  
     OriGene qPCR primer pairs and template standards for CLYBL   OriGene Protein Over-expression Lysate for CLYBL  
     OriGene MassSpec something-or-other for CLYBL   OriGene clones in human, mouse for CLYBL  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLYBL   OriGene Purified Protein for CLYBL  
     OriGene ORF clones in mouse, rat for CLYBL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLYBL   OriGene Custom Protein Services for CLYBL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLYBL
     QIAGEN SeqTarget long-range PCR primers for resequencing CLYBL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLYBL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLYBL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLYBL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLYBL
     GenScript Custom Purified and Recombinant Proteins Services for CLYBL GenScript cDNA clones with any tag delivered in your preferred vector for CLYBL
     GenScript Custom Assay Services for CLYBL GenScript Custom Superior Antibodies Services for CLYBL
     GenScript Custom overexpressing Cell Line Services for CLYBL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLYBL promoter
     Search Chromatin IP Primers for CLYBL
     RT2 qPCR Primer Assay in human, mouse / rat CLYBL
     Search GNC Networks for CLYBL
     SABiosciences Custom PCR Arrays for CLYBL
     Search Tocris compounds for CLYBL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CLYBL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLYBL antibodies
     CLYBL proteins
     CLYBL lysates
     Antibodies for CLYBL
     See all of Abcam's Antibodies, Kits and Proteins for CLYBL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CLYBL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLYBL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CLYBL
     SwitchGear Promoter luciferase reporter plasmids for CLYBL
     ThermoFisher Antibody for CLYBL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLYBL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLYBL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLYBL
    Customized:
     lentivirus for stable overexpression of CLYBL
     lentivirus expression plasmids for stable overexpression of CLYBL
     adenovirus for overexpression of CLYBL
     Search LSBio for Antibodies for CLYBL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLYBL gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4