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CLVS2 Gene

protein-coding   GIFtS: 45
GCID: GC06P123360

Clavesin 2

(Previous names: chromosome 6 open reading frame 212, chromosome 6 open reading...)
(Previous symbols: C6orf212, C6orf213, RLBP1L2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Clavesin 21 2     Chromosome 6 Open Reading Frame 2121
C6orf2121 2 3     Chromosome 6 Open Reading Frame 2131
C6orf2131 2 3     bA160A10.42
RLBP1L21 2 3     clavesin-22
Retinaldehyde Binding Protein 1-Like 21 2     Retinaldehyde-Binding Protein 1-Like 23

External Ids:    HGNC: 230461   Entrez Gene: 1348292   Ensembl: ENSG000001463527   UniProtKB: Q5SYC13   

Export aliases for CLVS2 gene to outside databases

Previous GC identifer: GC06P120894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLVS2 Gene:
This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is
thought to function in the endosomal pathway between early endosomes and mature lysosomes. (provided by RefSeq,
Aug 2013)

GeneCards Summary for CLVS2 Gene:
CLVS2 (clavesin 2) is a protein-coding gene. Diseases associated with CLVS2 include malaria, and prostate cancer. GO annotations related to this gene include transporter activity and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is TTPAL.

UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1
Function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds
phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CLVS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLVS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLVS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.31

CLVS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLVS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P123360:  view genomic region     (about GC identifiers)

Start:
123,317,116 bp from pter      End:
123,394,072 bp from pter
Size:
76,957 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1 (See protein sequence)
Recommended Name: Clavesin-2  
Size: 327 amino acids; 38000 Da
Subunit: Forms a complex with clathrin heavy chain and gamma-adaptin
Miscellaneous: Binding to PtdIns(3,5)P2 is not required for localization (By similarity)
Secondary accessions: B3KTG5 B4DHL0 C8UZT4 Q5SYC0
Alternative splicing: 2 isoforms:  Q5SYC1-1   Q5SYC1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLVS2: NX_Q5SYC1

Explore proteomics data for CLVS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLVS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010852.2  
    ENSEMBL proteins: 
     ENSP00000275162   ENSP00000357423  

    CLVS2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLVS2
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    Cloud-Clone Corp. Proteins for CLVS2

    CLVS2 Antibody Products:

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    Abcam antibodies for CLVS2 (Q5SYC1, Q8IUQ0)
    Cloud-Clone Corp. Antibodies for CLVS2
    Search ThermoFisher Antibodies for CLVS2
    LSBio Antibodies in human, mouse, rat for CLVS2

    CLVS2 Assay Products:

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    Cloud-Clone Corp. CLIAs for CLVS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001071 CRAL-bd_toc_tran
     IPR001251 CRAL-TRIO_dom
     IPR011074 CRAL/TRIO_N_dom
     IPR028636 Clavesin-2

    Graphical View of Domain Structure for InterPro Entry Q5SYC1

    ProtoNet protein and cluster: Q5SYC1

    2 Blocks protein domains:
    IPB001071 Cellular retinaldehyde-binding protein signature
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)


    UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1
    Domain: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2
    Similarity: Contains 1 CRAL-TRIO domain


    CLVS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLVS2_HUMAN, Q5SYC1
    Function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds
    phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0080025phosphatidylinositol-3,5-bisphosphate binding IDA19651769
         
    CLVS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLVS2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLVS2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLVS2
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CLVS2:
    hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidCLVS2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CLVS2

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    Sino Biological Human cDNA Clone for CLVS2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLVS2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLVS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLVS2_HUMAN, Q5SYC1: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity).
    Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). Early endosome membrane; Peripheral membrane
    protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    golgi apparatus3
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA19651769
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network ISS--
    GO:0030136clathrin-coated vesicle ISS--
    GO:0031901early endosome membrane IEA--

    CLVS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLVS2
    Interactions:

        Search GeneGlobe Interaction Network for CLVS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CLVS2 (ENSP000002751624) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC4ENSP000002538614STRING: ENSP00000253861
    MRGBPENSP000003595184STRING: ENSP00000359518
    PFDN4ENSP000003604734STRING: ENSP00000360473
    PFDN5ENSP000003341884STRING: ENSP00000334188
    PI4KBENSP000002716574STRING: ENSP00000271657
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007040lysosome organization ISS--

    CLVS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLVS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLVS2 gene: 
    NM_001010852.3  

    Unigene Cluster for CLVS2:

    Clavesin 2
    Hs.486361  [show with all ESTs]
    Unigene Representative Sequence: AK095527
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275162(uc003pzi.1) ENST00000368438
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLVS2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CLVS2:
    hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidCLVS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLVS2
    Predesigned siRNA for gene silencing in human, mouse, rat CLVS2
    Clone
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    OriGene clones in human, mouse for CLVS2 (see all 6)
    OriGene ORF clones in mouse, rat for CLVS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLVS2 (NM_001010852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLVS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLVS2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLVS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLVS2
      QuantiTect SYBR Green Assays in human, mouse, rat CLVS2
      QuantiFast Probe-based Assays in human, mouse, rat CLVS2

    Additional mRNA sequence: 

    AK095527.1 AK295158.1 BC101376.1 BC101377.2 

    1 DOTS entry:

    DT.99936993 

    3 AceView cDNA sequences:

    AK095527 BE796967 BG899217 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLVS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGTAGC
    CLVS2 Expression
    About this image


    CLVS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    CLVS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLVS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486361
        Custom PCR Arrays for CLVS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLVS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLVS2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clvs21 , 5 clavesin 21, 5 90.72(n)1
    97.86(a)1
      10 (18.62 cM)5
    2158901  NM_175448.31  NP_780657.11 
     335122865 
    chicken
    (Gallus gallus)
    Aves CLVS21 clavesin 2 86.44(n)
    97.25(a)
      428616  XM_426173.4  XP_426173.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLVS26
    clavesin 2
    91(a)
    1 ↔ 1
    1(182100662-182156308)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clvs21 clavesin 2 79.51(n)
    95.41(a)
      100496225  XM_002937219.2  XP_002937265.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clvs21 clavesin 2 78.7(n)
    89.3(a)
      566769  NM_001025545.2  NP_001020716.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106576
    CG339666
    (see all 17)
    --
    27(a)
    25(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    3L(12484930-12490316)
    3L(1234130-1235420)


    ENSEMBL Gene Tree for CLVS2 (if available)
    TreeFam Gene Tree for CLVS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLVS2 gene
    TTPAL2  RLBP12  CLVS12  TTPA2  
    5 SIMAP similar genes for CLVS2 using alignment to 1 protein entry:     CLVS2_HUMAN:
    CLVS1    RLBP1    DKFZp686E0870    TTPA    TTPAL

    CLVS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLVS2 (see all 1259)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668320911,2
    C--120917197(-) TTTTT-/AA/   
       AAA
    /T
    AAAAA
    2 -- int1 cds11NA 2
    rs1470764711,2
    --123315629(+) ACAGAA/TAGCTA 1 -- us2k10--------
    rs1148109251,2
    F--123315861(+) GGGCAA/GTTAGT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs69257171,2
    C,F,A--123315965(+) CGAAAC/TATAAA 1 -- us2k16Minor allele frequency- T:0.25NA WA CSA EA 364
    rs77621701,2
    C,F,A,H--123316097(+) TCCTAG/AAAGGA 1 -- us2k18Minor allele frequency- A:0.33WA NA CSA EA 368
    rs1171239421,2
    F--123316101(+) AGAAGG/AACCTT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1507004201,2
    C--123316203(+) ATGAC-/TGTGTG
            
    TGTGT
    1 -- cds10--------
    rs720209241,2
    C--123316204(+) ATGAC-/TGTGTGT 1 -- us2k10--------
    rs715412191,2
    C--123316206(+) TGTGT-/GT/   
      GTGTGT
    AATTT
    2 -- us2k1 cds11NA 2
    rs1837694031,2
    --123316266(+) AATTTA/GCATTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLVS2 (123317116 - 123394072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLVS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732655CNV Deletion23290073
    esv2671436CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLVS2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for CLVS2:    
    About MalaCards
    malaria    prostate cancer    neuronitis    prostatitis


    CLVS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLVS2

    Export disorders for CLVS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLVS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CLVS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. (PubMed id 19651769)1, 2, 3 Katoh Y....McPherson P.S. (J. Biol. Chem. 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134829 HGNC: 23046 AceView: C6orf213 Ensembl:ENSG00000146352 euGenes: HUgn134829
    ECgene: CLVS2 H-InvDB: CLVS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLVS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLVS2 gene:
    Search GeneIP for patents involving CLVS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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