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Aliases for CLVS1 Gene

Aliases for CLVS1 Gene

  • Clavesin 1 2 3
  • RLBP1L1 3 4 6
  • CRALBPL 3 4 6
  • Retinaldehyde Binding Protein 1-Like 1 2 3
  • Retinaldehyde-Binding Protein 1-Like 1 3 4
  • Cellular Retinaldehyde-Binding Protein-Like 4
  • Clavesin-1 3

External Ids for CLVS1 Gene

Previous HGNC Symbols for CLVS1 Gene

  • RLBP1L1

Previous GeneCards Identifiers for CLVS1 Gene

  • GC08P062365
  • GC08P062201
  • GC08P057689
  • GC08P061969

Summaries for CLVS1 Gene

GeneCards Summary for CLVS1 Gene

CLVS1 (Clavesin 1) is a Protein Coding gene. Diseases associated with CLVS1 include duane retraction syndrome. GO annotations related to this gene include transporter activity and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is RLBP1.

UniProtKB/Swiss-Prot for CLVS1 Gene

  • Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLVS1 Gene

Genomics for CLVS1 Gene

Genomic Location for CLVS1 Gene

61,057,158 bp from pter
61,501,645 bp from pter
444,488 bases
Plus strand

Genomic View for CLVS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLVS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLVS1 Gene

No data available for Regulatory Elements for CLVS1 Gene

Proteins for CLVS1 Gene

  • Protein details for CLVS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R7M5
    • C8UZT3
    • Q8NB32

    Protein attributes for CLVS1 Gene

    354 amino acids
    Molecular mass:
    40788 Da
    Quaternary structure:
    • Forms a complex with clathrin heavy chain and gamma-adaptin.
    • Binding to PtdIns(3,5)P2 is not required for localization

    Alternative splice isoforms for CLVS1 Gene


neXtProt entry for CLVS1 Gene

Proteomics data for CLVS1 Gene at MOPED

Post-translational modifications for CLVS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLVS1 Gene

Antibody Products

No data available for DME Specific Peptides for CLVS1 Gene

Domains for CLVS1 Gene

Suggested Antigen Peptide Sequences for CLVS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IUQ0
  • The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with CLVS1: view

No data available for Gene Families for CLVS1 Gene

Function for CLVS1 Gene

Molecular function for CLVS1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

Gene Ontology (GO) - Molecular Function for CLVS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA 19651769
genes like me logo Genes that share ontologies with CLVS1: view

Animal Model Products

miRNA for CLVS1 Gene

miRTarBase miRNAs that target CLVS1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLVS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLVS1 Gene

Localization for CLVS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLVS1 Gene

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Early endosome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CLVS1 Gene COMPARTMENTS Subcellular localization image for CLVS1 gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
nucleus 2
peroxisome 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CLVS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 19651769
GO:0005802 trans-Golgi network ISS --
GO:0016020 membrane --
GO:0030136 clathrin-coated vesicle ISS --
GO:0030669 clathrin-coated endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with CLVS1: view

Pathways for CLVS1 Gene

SuperPathways for CLVS1 Gene

No Data Available

Interacting Proteins for CLVS1 Gene

Gene Ontology (GO) - Biological Process for CLVS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0007040 lysosome organization ISS --
GO:0061024 membrane organization TAS --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with CLVS1: view

No data available for Pathways by source for CLVS1 Gene

Transcripts for CLVS1 Gene

Unigene Clusters for CLVS1 Gene

Clavesin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLVS1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLVS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP5: -

Relevant External Links for CLVS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLVS1 Gene

mRNA expression in normal human tissues for CLVS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLVS1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.9), Brain - Nucleus accumbens (basal ganglia) (5.5), Brain - Frontal Cortex (BA9) (5.1), and Brain - Anterior cingulate cortex (BA24) (4.2).

Protein differential expression in normal tissues for CLVS1 Gene

This gene is overexpressed in Frontal cortex (53.3) and Fetal Brain (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLVS1 Gene

SOURCE GeneReport for Unigene cluster for CLVS1 Gene Hs.591874

mRNA Expression by UniProt/SwissProt for CLVS1 Gene

Tissue specificity: Expressed mainly in the brain.
genes like me logo Genes that share expressions with CLVS1: view

Expression partners for CLVS1 Gene

In Situ Assay Products

Orthologs for CLVS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLVS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLVS1 35
  • 93.5 (n)
  • 97.74 (a)
CLVS1 36
  • 98 (a)
(Canis familiaris)
Mammalia CLVS1 35
  • 93.41 (n)
  • 98.87 (a)
CLVS1 36
  • 99 (a)
(Mus musculus)
Mammalia Clvs1 35
  • 89.55 (n)
  • 97.18 (a)
Clvs1 16
Clvs1 36
  • 97 (a)
(Pan troglodytes)
Mammalia CLVS1 35
  • 99.62 (n)
  • 100 (a)
CLVS1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Clvs1 35
  • 90.77 (n)
  • 97.18 (a)
(Monodelphis domestica)
Mammalia CLVS1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia CLVS1 36
  • 73 (a)
(Gallus gallus)
Aves CLVS1 35
  • 85.44 (n)
  • 94.58 (a)
CLVS1 36
  • 95 (a)
(Anolis carolinensis)
Reptilia CLVS1 36
  • 95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10300 36
  • 20 (a)
CG10301 36
  • 18 (a)
CG10657 36
  • 28 (a)
CG11550 36
  • 19 (a)
CG12926 36
  • 23 (a)
CG1902 36
  • 21 (a)
CG2663 36
  • 23 (a)
CG30339 36
  • 23 (a)
CG3091 36
  • 16 (a)
CG31636 36
  • 21 (a)
CG3191 36
  • 18 (a)
CG33514 36
  • 21 (a)
CG33965 36
  • 18 (a)
CG33966 36
  • 24 (a)
CG3823 36
  • 19 (a)
Cralbp 36
  • 23 (a)
pinta 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for CLVS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLVS1 Gene

Gene Tree for CLVS1 (if available)
Gene Tree for CLVS1 (if available)

Paralogs for CLVS1 Gene

Paralogs for CLVS1 Gene

Selected SIMAP similar genes for CLVS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CLVS1: view

Variants for CLVS1 Gene

Sequence variations from dbSNP and Humsavar for CLVS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2444 -- 61,499,744(-) GGGGG(A/G)AAAAA utr-variant-3-prime
rs2445 -- 61,499,742(-) GGGAA(A/G)AAAAA utr-variant-3-prime
rs745206 -- 61,325,711(+) CCATA(G/T)CTGTG intron-variant
rs867920 -- 61,468,723(+) aaaaa(A/G)aaaaa intron-variant
rs870002 -- 61,307,592(-) TTGTG(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLVS1 Gene

Variant ID Type Subtype PubMed ID
nsv831336 CNV Gain 17160897
nsv523363 CNV Loss 19592680
esv7324 CNV Gain 19470904
nsv6223 CNV Loss 18451855
nsv521898 CNV Gain 19592680
esv987877 CNV Insertion 20482838
esv23432 CNV Gain 19812545
dgv184e180 CNV Gain 20482838
esv992867 CNV Insertion 20482838
esv1001731 CNV Insertion 20482838

Relevant External Links for CLVS1 Gene

HapMap Linkage Disequilibrium report

PCR Panel Products

  • Copy Number PCR Panels: for CLVS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLVS1 Gene

Disorders for CLVS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CLVS1 Gene in MalaCards »

(1) Diseases for CLVS1 Gene including...

(1) University of Copenhagen DISEASES for CLVS1 Gene

Relevant External Links for CLVS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLVS1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CLVS1 Gene

Publications for CLVS1 Gene

  1. Cloning and characterization of a novel, human cellular retinaldehyde-binding protein CRALBP-like (CRALBPL) gene. (PMID: 16802092) Kong Y.-H. … Yu L. (Biotechnol. Lett. 2006) 2 3 4
  2. The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. (PMID: 19651769) Katoh Y. … McPherson P.S. (J. Biol. Chem. 2009) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CLVS1 Gene

Sources for CLVS1 Gene

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