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Aliases for CLUL1 Gene

Aliases for CLUL1 Gene

  • Clusterin Like 1 2 3 5
  • Retinal-Specific Clusterin-Like Protein 3 4
  • Retinal Clusterin-Like Protein 2 3
  • Clusterin-Like 1 (Retinal) 2 3
  • RA337M 3

External Ids for CLUL1 Gene

Previous GeneCards Identifiers for CLUL1 Gene

  • GC18P000880
  • GC18P000584
  • GC18P000586

Summaries for CLUL1 Gene

GeneCards Summary for CLUL1 Gene

CLUL1 (Clusterin Like 1) is a Protein Coding gene. An important paralog of this gene is CLU.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUL1 Gene

Genomics for CLUL1 Gene

Regulatory Elements for CLUL1 Gene

Promoters for CLUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLUL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLUL1 Gene

Chromosome:
18
Start:
596,988 bp from pter
End:
650,334 bp from pter
Size:
53,347 bases
Orientation:
Plus strand

Genomic View for CLUL1 Gene

Genes around CLUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUL1 Gene

Proteins for CLUL1 Gene

  • Protein details for CLUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15846-CLUL1_HUMAN
    Recommended name:
    Clusterin-like protein 1
    Protein Accession:
    Q15846
    Secondary Accessions:
    • A0FDN7

    Protein attributes for CLUL1 Gene

    Size:
    466 amino acids
    Molecular mass:
    54215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLUL1 Gene

Proteomics data for CLUL1 Gene at MOPED

Post-translational modifications for CLUL1 Gene

  • Glycosylation at Asn 196, Asn 257, Asn 311, Asn 351, Asn 412, and Asn 431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUL1 Gene

Domains & Families for CLUL1 Gene

Protein Domains for CLUL1 Gene

Suggested Antigen Peptide Sequences for CLUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15846

UniProtKB/Swiss-Prot:

CLUL1_HUMAN :
  • Belongs to the clusterin family.
Family:
  • Belongs to the clusterin family.
genes like me logo Genes that share domains with CLUL1: view

No data available for Gene Families for CLUL1 Gene

Function for CLUL1 Gene

genes like me logo Genes that share phenotypes with CLUL1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLUL1 Gene

Localization for CLUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLUL1 Gene COMPARTMENTS Subcellular localization image for CLUL1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for CLUL1 Gene

Pathways & Interactions for CLUL1 Gene

SuperPathways for CLUL1 Gene

No Data Available

Interacting Proteins for CLUL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341128%0d%0a9606.ENSP00000352257%0d%0a9606.ENSP00000317955%0d%0a
Selected Interacting proteins: ENSP00000341128 for CLUL1 Gene via STRING

Gene Ontology (GO) - Biological Process for CLUL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLUL1 Gene

Drugs & Compounds for CLUL1 Gene

No Compound Related Data Available

Transcripts for CLUL1 Gene

Unigene Clusters for CLUL1 Gene

Clusterin-like 1 (retinal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - -
SP6: -

Relevant External Links for CLUL1 Gene

GeneLoc Exon Structure for
CLUL1
ECgene alternative splicing isoforms for
CLUL1

Expression for CLUL1 Gene

mRNA expression in normal human tissues for CLUL1 Gene

Protein differential expression in normal tissues from HIPED for CLUL1 Gene

This gene is overexpressed in Vitreous humor (42.4), Plasma (17.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLUL1 Gene



SOURCE GeneReport for Unigene cluster for CLUL1 Gene Hs.732341

genes like me logo Genes that share expression patterns with CLUL1: view

Protein tissue co-expression partners for CLUL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLUL1 Gene

Orthologs for CLUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUL1 36
  • 88 (a)
OneToOne
CLUL1 35
  • 99.1 (n)
  • 97.88 (a)
cow
(Bos Taurus)
Mammalia CLUL1 36
  • 71 (a)
OneToOne
CLUL1 35
  • 82.29 (n)
  • 70.97 (a)
dog
(Canis familiaris)
Mammalia CLUL1 35
  • 85.38 (n)
  • 73.55 (a)
CLUL1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLUL1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLUL1 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clul1 35
  • 75.79 (n)
  • 60.56 (a)
chicken
(Gallus gallus)
Aves CLUL1 35
  • 64.52 (n)
  • 52.99 (a)
CLUL1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLUL1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clul1 35
  • 50.91 (n)
  • 33.64 (a)
zebrafish
(Danio rerio)
Actinopterygii clul1 36
  • 30 (a)
OneToOne
clul1 35
  • 46.8 (n)
  • 33.48 (a)
Species with no ortholog for CLUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLUL1 Gene

ENSEMBL:
Gene Tree for CLUL1 (if available)
TreeFam:
Gene Tree for CLUL1 (if available)

Paralogs for CLUL1 Gene

Paralogs for CLUL1 Gene

genes like me logo Genes that share paralogs with CLUL1: view

Variants for CLUL1 Gene

Sequence variations from dbSNP and Humsavar for CLUL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs485312 -- 616,783(+) ATTAA(A/T)AAGTT intron-variant
rs486965 -- 643,814(+) TATAA(A/G)GGAAG intron-variant
rs493609 -- 606,115(-) CACCC(A/T)TAGGG intron-variant
rs495493 -- 612,454(-) AGGGG(C/T)GCACG intron-variant, upstream-variant-2KB
rs543813 -- 595,605(-) TCACC(A/C/G)GATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLUL1 Gene

Variant ID Type Subtype PubMed ID
nsv909287 CNV Gain 21882294
nsv909288 CNV Loss 21882294
nsv909289 CNV Loss 21882294
nsv833577 CNV Gain+Loss 17160897
nsv909292 CNV Gain 21882294
nsv528169 CNV Loss 19592680
nsv909293 CNV Loss 21882294
esv2716645 CNV Deletion 23290073
esv2716646 CNV Deletion 23290073
esv2663170 CNV Deletion 23128226
esv2716648 CNV Deletion 23290073
esv2716649 CNV Deletion 23290073
dgv574e199 CNV Deletion 23128226
esv2676596 CNV Deletion 23128226
esv2716650 CNV Deletion 23290073
esv1619817 CNV Deletion 17803354
nsv131524 CNV Loss 16902084

Variation tolerance for CLUL1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLUL1 Gene

HapMap Linkage Disequilibrium report
CLUL1
Human Gene Mutation Database (HGMD)
CLUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLUL1 Gene

Disorders for CLUL1 Gene

Relevant External Links for CLUL1

Genetic Association Database (GAD)
CLUL1
Human Genome Epidemiology (HuGE) Navigator
CLUL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLUL1

No disorders were found for CLUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLUL1 Gene

Publications for CLUL1 Gene

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor- specific gene. (PMID: 14507903) Zhang Q. … Aguirre G.D. (Invest. Ophthalmol. Vis. Sci. 2003) 2 3 4 23 67
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PMID: 10675623) Zhang Q. … Aguirre G.D. (Gene 2000) 2 3 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for CLUL1 Gene

Sources for CLUL1 Gene

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