CLUL1 Gene
protein-coding GIFtS: 48
GCID: GC18P000586
|
|
clusterin-like 1 (retinal)
| |
Aliases
for CLUL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Clusterin-Like 1 (Retinal)1 2 | | Retinal-Specific Clusterin-Like Protein2 3 | | RA337M2 | | Clusterin-Like Protein 12 |
Export aliases for CLUL1 gene to outside databasesPrevious GC identifers: GC18P000880 GC18P000584 |
Summaries
for CLUL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CLUL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLUL1 gene promoter:
SRF Sp1 Bach2 SRF (504 AA) Gfi-1 IRF-2 Pax-3 Ik-2 GATA-6 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLUL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLUL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.32CLUL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P000586: view genomic region
(about GC identifiers)
Start:
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596,988 bp from pter |
End:
|
650,334 bp from pter |
Size:
|
53,347 bases |
Orientation:
|
plus strand |
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Proteins
for CLUL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLUL1_HUMAN, Q15846 (See
protein sequence)Recommended Name: Clusterin-like protein 1 precursor Size: 466 amino acids; 54215 Da
Subcellular location: Secreted (Probable)Explore the universe of human proteins at neXtProt for CLUL1: NX_Q15846
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15846
CLUL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055225.1 NP_954636.1
ENSEMBL proteins: ENSP00000383449 ENSP00000441726 ENSP00000463269 ENSP00000341128 ENSP00000464642
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CLUL1 for ontologies About GeneDecksing
CLUL1 Antibody Products:
Assay Products for CLUL1: |
Protein
Domains /
Families
for CLUL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLUL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15846ProtoNet protein and cluster: Q15846 UniProtKB/Swiss-Prot: CLUL1_HUMAN, Q15846Similarity: Belongs to the clusterin family |
Function
for CLUL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CLUL1 (NM_199167) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLUL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUL1 |
|
Pathways & Interactions
for CLUL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLUL1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CLUL1 (ENSP000003411284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008219 | cell death |
IEA | -- |
CLUL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLUL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLUL1
Search CenterWatch for drugs/clinical trials and news about CLUL1
|
Transcripts
for CLUL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLUL1 gene (2 alternative transcripts): NM_014410.4 NM_199167.1 Unigene Cluster for CLUL1: Clusterin-like 1 (retinal) Hs.732341 [show with all ESTs]Unigene Representative Sequence: AK29931913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579912 ENST00000582020 ENST00000580436 ENST00000400606(uc002kkp.3)
ENST00000579443 ENST00000540035(uc010wys.2) ENST00000581619 ENST00000584370
ENST00000580245 ENST00000338387(uc002kkq.3) ENST00000579494 ENST00000584046
ENST00000585155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CLUL1 (NM_199167) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLUL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUL1 |
Additional cDNA sequence: AF395889.1 AK299319.1 BC025381.2 D63813.1 DQ980621.1 7 DOTS entries: DT.100743389 DT.111185 DT.99976366 DT.100648146 DT.75176992 DT.95256060 DT.101977424 24/35 AceView cDNA sequences (see all 35): BQ637390 AA781524 CD105363 BC025381 BM692454 NM_199167 BQ017160 NM_014410 BM701786 AA317281 BX488227 AF395889 AL712219 BI489991 BV177012 BG704533 D63813 BX488483 BU728997 H91726 AK094657 H91647 AL712819 BI490823
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLUL1
|
Expression
for CLUL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLUL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACATTAGT
About this image
See CLUL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLUL1
SOURCE GeneReport for Unigene cluster: Hs.732341
SABiosciences Custom PCR Arrays for CLUL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLUL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLUL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUL1 |
Orthologs
for CLUL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLUL1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CLUL1 (if available)
TreeFam Gene Tree for CLUL1 (if available) |
Paralogs
for CLUL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLUL1 gene
- CLU2
18/20 SIMAP similar genes for CLUL1 using alignment to 4 protein entries: CLUL1_HUMAN (see all proteins)
(see all similar genes):ZNF212 CERS5 NF2 APOD CHID1 RNF217
LOC100506792 TMEM14B LYRM4 TCEB1 TCF4 UTY
CLU TSEN2 LINC00596 FAM175A SEPT2 SHANK2
CLUL1 for paralogs About GeneDecksing
|
Genomic Variants
for CLUL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLUL1 (596988 - 650334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLUL1
1 CNV: 5044
Human Gene Mutation Database (HGMD): CLUL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLUL1 |
|
Disorders
/ Diseases
for CLUL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLUL1 for disorders About GeneDecksing
5  diseases for CLUL1: About MalaCardsage related macular degeneration retinitis myopia-2 macular degeneration
myopia
1 Novoseek disease relationship for CLUL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinopathy |
51 |
2 |
14507903 (1), 10675623 (1) |
Human Genome Epidemiology (HuGE) Navigator: CLUL1 (4 documents)
Export disorders for CLUL1 gene to outside databases
|
Publications
for CLUL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLUL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLUL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. (PubMed id 14507903)1, 2, 3, 9 Zhang Q....Aguirre G.D. (2003)
- Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PubMed id 10675623)1, 3, 9 Zhang Q....Aguirre G.D. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1 Roni V.... Wissinger B. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Mutation screen of the cone-specific gene, CLUL1, in 376 patients with age-related macular degeneration. (PubMed id 17148042)9 Sturgill G.M....Hagstrom S.A. (2006)
- Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes. (PubMed id 15723005)9 Scavello G.S....Young T.L. (2005)
|
External Searches for CLUL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLUL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLUL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLUL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLUL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLUL1 gene:
Search GeneIP for patents involving CLUL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLUL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLUL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLUL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLUL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLUL1 | | OriGene 3'-UTR Clone for CLUL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLUL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLUL1 | | OriGene Custom Protein Services for CLUL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLUL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLUL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLUL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLUL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLUL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLUL1 |
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 |  |  |  | |
| | | | Search Tocris compounds for CLUL1 |
| |  |  |  |  | | | | |
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 | | | CLUL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CLUL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUL1 |
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