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Aliases for CLUL1 Gene

Aliases for CLUL1 Gene

  • Clusterin Like 1 2 3 5
  • Retinal-Specific Clusterin-Like Protein 3 4
  • Retinal Clusterin-Like Protein 2 3
  • Clusterin-Like 1 (Retinal) 2 3
  • Clusterin-Like Protein 1 3
  • RA337M 3

External Ids for CLUL1 Gene

Previous GeneCards Identifiers for CLUL1 Gene

  • GC18P000880
  • GC18P000584
  • GC18P000586

Summaries for CLUL1 Gene

GeneCards Summary for CLUL1 Gene

CLUL1 (Clusterin Like 1) is a Protein Coding gene. An important paralog of this gene is CLU.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUL1 Gene

Genomics for CLUL1 Gene

Regulatory Elements for CLUL1 Gene

Enhancers for CLUL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G000596 1 ENCODE 29.5 -0.1 -120 1.4 HDGF ATF1 PKNOX1 ARID4B ZNF48 ZNF121 GLIS2 CBX5 ZNF143 SP3 CLUL1 RN7SKP146
GH18G000322 1.6 FANTOM5 Ensembl ENCODE 10.4 -274.3 -274279 1.2 FOXA2 CREB3L1 ARNT ARID4B FOS JUNB REST MEF2D SSRP1 MIER3 THOC1 ENSG00000264514 CETN1 CLUL1 GC18P000404
GH18G000679 1.4 FANTOM5 ENCODE dbSUPER 11 +86.4 86369 7.9 SOX13 FOXA2 PKNOX1 TEAD4 ZNF384 CHD7 ZIC2 YY1 ZFHX2 POLR2A ENOSF1 TYMS TYMSOS CLUL1 RNU1-109P ENSG00000265490 GC18M000704 PIR56960
GH18G000474 1.3 Ensembl ENCODE dbSUPER 10.6 -121.4 -121427 2.4 CTCF ELF3 SAP130 ZNF792 JUN TEAD4 ZNF7 RARA TEAD3 ETS1 COLEC12 THOC1 CLUL1 CETN1 USP14 GC18P000435
GH18G000478 1.2 Ensembl ENCODE dbSUPER 11.1 -117.8 -117791 2.3 ELF3 ESRRA SAP130 ZFP64 JUN TEAD3 FOSL1 EGR1 NR2F6 FOS CLUL1 USP14 COLEC12 GC18P000435
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLUL1 on UCSC Golden Path with GeneCards custom track

Promoters for CLUL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099837 12 801 HDGF ATF1 PKNOX1 ARID4B ZNF48 GLIS2 CBX5 ZNF143 SP3 REST

Genomic Location for CLUL1 Gene

Chromosome:
18
Start:
596,988 bp from pter
End:
650,334 bp from pter
Size:
53,347 bases
Orientation:
Plus strand

Genomic View for CLUL1 Gene

Genes around CLUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUL1 Gene

Proteins for CLUL1 Gene

  • Protein details for CLUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15846-CLUL1_HUMAN
    Recommended name:
    Clusterin-like protein 1
    Protein Accession:
    Q15846
    Secondary Accessions:
    • A0FDN7

    Protein attributes for CLUL1 Gene

    Size:
    466 amino acids
    Molecular mass:
    54215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLUL1 Gene

Post-translational modifications for CLUL1 Gene

  • Glycosylation at posLast=196196, posLast=257257, posLast=311311, posLast=351351, posLast=412412, and posLast=431431
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUL1 Gene

Domains & Families for CLUL1 Gene

Protein Domains for CLUL1 Gene

Suggested Antigen Peptide Sequences for CLUL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15846

UniProtKB/Swiss-Prot:

CLUL1_HUMAN :
  • Belongs to the clusterin family.
Family:
  • Belongs to the clusterin family.
genes like me logo Genes that share domains with CLUL1: view

No data available for Gene Families for CLUL1 Gene

Function for CLUL1 Gene

genes like me logo Genes that share phenotypes with CLUL1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLUL1 Gene

Localization for CLUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLUL1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLUL1: view

Pathways & Interactions for CLUL1 Gene

SuperPathways for CLUL1 Gene

No Data Available

Interacting Proteins for CLUL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341128%0d%0a9606.ENSP00000352257%0d%0a9606.ENSP00000317955%0d%0a
Selected Interacting proteins: ENSP00000341128 for CLUL1 Gene via STRING

Gene Ontology (GO) - Biological Process for CLUL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLUL1 Gene

Drugs & Compounds for CLUL1 Gene

No Compound Related Data Available

Transcripts for CLUL1 Gene

Unigene Clusters for CLUL1 Gene

Clusterin-like 1 (retinal):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - -
SP6: -

Relevant External Links for CLUL1 Gene

GeneLoc Exon Structure for
CLUL1
ECgene alternative splicing isoforms for
CLUL1

Expression for CLUL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLUL1 Gene

Protein differential expression in normal tissues from HIPED for CLUL1 Gene

This gene is overexpressed in Vitreous humor (42.4), Plasma (17.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLUL1 Gene



Protein tissue co-expression partners for CLUL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLUL1 Gene:

CLUL1

SOURCE GeneReport for Unigene cluster for CLUL1 Gene:

Hs.732341

Evidence on tissue expression from TISSUES for CLUL1 Gene

  • Eye(4.7)
  • Nervous system(4.7)
  • Lung(2.9)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CLUL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLUL1 Gene

Orthologs for CLUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUL1 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CLUL1 34 35
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia CLUL1 34 35
  • 82.29 (n)
rat
(Rattus norvegicus)
Mammalia Clul1 34
  • 75.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CLUL1 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLUL1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLUL1 34 35
  • 64.52 (n)
lizard
(Anolis carolinensis)
Reptilia CLUL1 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clul1 34
  • 50.91 (n)
zebrafish
(Danio rerio)
Actinopterygii clul1 34 35
  • 46.8 (n)
Species where no ortholog for CLUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLUL1 Gene

ENSEMBL:
Gene Tree for CLUL1 (if available)
TreeFam:
Gene Tree for CLUL1 (if available)

Paralogs for CLUL1 Gene

Paralogs for CLUL1 Gene

genes like me logo Genes that share paralogs with CLUL1: view

Variants for CLUL1 Gene

Sequence variations from dbSNP and Humsavar for CLUL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000025117 -- 621,793(+) CGGGG(A/G)ACCCA intron-variant
rs1000039245 -- 646,474(+) TCCAA(C/G)AGGGG intron-variant, utr-variant-3-prime
rs1000040792 -- 642,361(+) CGGAA(A/G)GCAGA intron-variant, upstream-variant-2KB
rs1000107593 -- 648,132(+) GGTTC(A/C)CTCTA intron-variant, utr-variant-3-prime
rs1000200696 -- 615,615(+) GAAAA(A/G)TACCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CLUL1 Gene

Variant ID Type Subtype PubMed ID
dgv3307n100 CNV gain 25217958
dgv574e199 CNV deletion 23128226
dgv5810n54 CNV gain 21841781
esv1619817 CNV deletion 17803354
esv2663170 CNV deletion 23128226
esv2676596 CNV deletion 23128226
esv2716645 CNV deletion 23290073
esv2716646 CNV deletion 23290073
esv2716648 CNV deletion 23290073
esv2716649 CNV deletion 23290073
esv2716650 CNV deletion 23290073
esv3554939 CNV deletion 23714750
esv3582931 CNV loss 25503493
esv3582932 CNV loss 25503493
esv3641496 CNV loss 21293372
esv3641497 CNV gain 21293372
esv3641499 CNV loss 21293372
esv3641500 CNV loss 21293372
esv3641501 CNV loss 21293372
esv3641502 CNV loss 21293372
esv3641503 CNV gain 21293372
esv3641504 CNV loss 21293372
esv3893055 CNV gain 25118596
nsv1060188 CNV gain 25217958
nsv131524 CNV deletion 16902084
nsv482935 CNV loss 15286789
nsv528169 CNV loss 19592680
nsv576228 CNV loss 21841781
nsv576236 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576242 CNV gain 21841781
nsv576243 CNV gain 21841781
nsv576244 CNV loss 21841781
nsv833577 CNV gain+loss 17160897

Variation tolerance for CLUL1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLUL1 Gene

Human Gene Mutation Database (HGMD)
CLUL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLUL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLUL1 Gene

Disorders for CLUL1 Gene

Relevant External Links for CLUL1

Genetic Association Database (GAD)
CLUL1
Human Genome Epidemiology (HuGE) Navigator
CLUL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLUL1

No disorders were found for CLUL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLUL1 Gene

Publications for CLUL1 Gene

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor- specific gene. (PMID: 14507903) Zhang Q. … Aguirre G.D. (Invest. Ophthalmol. Vis. Sci. 2003) 2 3 4 22 64
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PMID: 10675623) Zhang Q. … Aguirre G.D. (Gene 2000) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3 4 64

Products for CLUL1 Gene

Sources for CLUL1 Gene

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