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Aliases for CLUL1 Gene

Aliases for CLUL1 Gene

  • Clusterin-Like 1 (Retinal) 2 3
  • Retinal-Specific Clusterin-Like Protein 3 4
  • Clusterin-Like Protein 1 3
  • RA337M 3

External Ids for CLUL1 Gene

Summaries for CLUL1 Gene

GeneCards Summary for CLUL1 Gene

CLUL1 (Clusterin-Like 1 (Retinal)) is a Protein Coding gene. An important paralog of this gene is CLU.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUL1 Gene

Genomics for CLUL1 Gene

Genomic Location for CLUL1 Gene

Start:
596,988 bp from pter
End:
650,334 bp from pter
Size:
53,347 bases
Orientation:
Plus strand

Genomic View for CLUL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLUL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUL1 Gene

Regulatory Elements for CLUL1 Gene

Proteins for CLUL1 Gene

  • Protein details for CLUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15846-CLUL1_HUMAN
    Recommended name:
    Clusterin-like protein 1
    Protein Accession:
    Q15846
    Secondary Accessions:
    • A0FDN7

    Protein attributes for CLUL1 Gene

    Size:
    466 amino acids
    Molecular mass:
    54215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLUL1 Gene

Proteomics data for CLUL1 Gene at MOPED

Post-translational modifications for CLUL1 Gene

  • Glycosylation at Asn196, Asn257, Asn311, Asn351, Asn412, and Asn431

No data available for DME Specific Peptides for CLUL1 Gene

Domains for CLUL1 Gene

Protein Domains for CLUL1 Gene

UniProtKB/Swiss-Prot:

CLUL1_HUMAN
Family:
  • Belongs to the clusterin family.:
    • Q15846
genes like me logo Genes that share domains with CLUL1: view

No data available for Gene Families for CLUL1 Gene

Function for CLUL1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLUL1 Gene

Localization for CLUL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLUL1 Gene COMPARTMENTS Subcellular localization image for CLUL1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLUL1: view

Pathways for CLUL1 Gene

SuperPathways for CLUL1 Gene

No Data Available

Interacting Proteins for CLUL1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341128%0d%0a9606.ENSP00000352257%0d%0a9606.ENSP00000317955%0d%0a
Selected Interacting proteins: ENSP00000341128 for CLUL1 Gene via STRING

Gene Ontology (GO) - Biological Process for CLUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IEA --
genes like me logo Genes that share ontologies with CLUL1: view

No data available for Pathways by source for CLUL1 Gene

Transcripts for CLUL1 Gene

Unigene Clusters for CLUL1 Gene

Clusterin-like 1 (retinal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLUL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - -
SP6: -

Relevant External Links for CLUL1 Gene

GeneLoc Exon Structure for
CLUL1
ECgene alternative splicing isoforms for
CLUL1

Expression for CLUL1 Gene

mRNA expression in normal human tissues for CLUL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLUL1 Gene

SOURCE GeneReport for Unigene cluster for CLUL1 Gene Hs.732341

genes like me logo Genes that share expressions with CLUL1: view

Orthologs for CLUL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLUL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUL1 36
  • 99.1 (n)
  • 97.88 (a)
CLUL1 37
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLUL1 36
  • 82.29 (n)
  • 70.97 (a)
CLUL1 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLUL1 36
  • 85.38 (n)
  • 73.55 (a)
CLUL1 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLUL1 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLUL1 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clul1 36
  • 75.79 (n)
  • 60.56 (a)
chicken
(Gallus gallus)
Aves CLUL1 36
  • 64.52 (n)
  • 52.99 (a)
CLUL1 37
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLUL1 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clul1 36
  • 50.91 (n)
  • 33.64 (a)
zebrafish
(Danio rerio)
Actinopterygii clul1 36
  • 46.8 (n)
  • 33.48 (a)
clul1 37
  • 30 (a)
OneToOne
Species with no ortholog for CLUL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLUL1 Gene

ENSEMBL:
Gene Tree for CLUL1 (if available)
TreeFam:
Gene Tree for CLUL1 (if available)

Paralogs for CLUL1 Gene

Paralogs for CLUL1 Gene

genes like me logo Genes that share paralogs with CLUL1: view

Variants for CLUL1 Gene

Sequence variations from dbSNP and Humsavar for CLUL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs188266 -- 630,522(-) tcttg(G/T)ggctg intron-variant
rs190821 -- 614,323(-) tcctt(A/C)cctcc intron-variant
rs476590 -- 616,348(+) TTTTC(A/G)AACTG intron-variant, upstream-variant-2KB
rs476896 -- 620,695(-) ATGTA(A/G)TTCAA intron-variant
rs479141 -- 616,582(+) AACAG(C/T)ACCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLUL1 Gene

Variant ID Type Subtype PubMed ID
nsv909287 CNV Gain 21882294
nsv909288 CNV Loss 21882294
nsv909289 CNV Loss 21882294
nsv833577 CNV Gain+Loss 17160897
nsv909292 CNV Gain 21882294
nsv528169 CNV Loss 19592680
nsv909293 CNV Loss 21882294
esv2716645 CNV Deletion 23290073
esv2716646 CNV Deletion 23290073
esv2663170 CNV Deletion 23128226
esv2716648 CNV Deletion 23290073
esv2716649 CNV Deletion 23290073
dgv574e199 CNV Deletion 23128226
esv2676596 CNV Deletion 23128226
esv2716650 CNV Deletion 23290073
esv1619817 CNV Deletion 17803354
nsv131524 CNV Loss 16902084

Relevant External Links for CLUL1 Gene

HapMap Linkage Disequilibrium report
CLUL1
Human Gene Mutation Database (HGMD)
CLUL1

Disorders for CLUL1 Gene

(1) Novoseek inferred disease relationships for CLUL1 Gene

Disease -log(P) Hits PubMed IDs
retinopathy 51 2

Relevant External Links for CLUL1

Genetic Association Database (GAD)
CLUL1
Human Genome Epidemiology (HuGE) Navigator
CLUL1
genes like me logo Genes that share disorders with CLUL1: view

No data available for UniProtKB/Swiss-Prot for CLUL1 Gene

Publications for CLUL1 Gene

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor- specific gene. (PMID: 14507903) Zhang Q. … Aguirre G.D. (Invest. Ophthalmol. Vis. Sci. 2003) 2 3 4 23
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. (PMID: 10675623) Zhang Q. … Aguirre G.D. (Gene 2000) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CLUL1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLUL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CLUL1
  • Block miRNA regulation of CLUL1 using miScript Target Protectors

Sources for CLUL1 Gene

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