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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLUH Gene

protein-coding   GIFtS: 44
GCID: GC17M002593

Clustered Mitochondria (CluA/CLU1) Homolog

(Previous name: KIAA0664)
(Previous symbol: KIAA0664)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Clustered Mitochondria (CluA/CLU1) Homolog1 2
KIAA06641 2 3
CLU12
Clustered Mitochondria Protein Homolog2

External Ids:    HGNC: 290941   Entrez Gene: 232772   Ensembl: ENSG000001323617   UniProtKB: O751533   

Export aliases for CLUH gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLUH Gene: 
CLUH (clustered mitochondria (cluA/CLU1) homolog) is a protein-coding gene. Diseases associated with CLUH include measles, and hepatitis c.

UniProtKB/Swiss-Prot: CLU_HUMAN, O75153
Function: Involved in proper cytoplasmic distribution of mitochondria (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CLUH
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLUH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLUH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

CLUH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLUH gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002593:  view genomic region     (about GC identifiers)

Start:
2,592,680 bp from pter      End:
2,615,957 bp from pter
Size:
23,278 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLU_HUMAN, O75153 (See protein sequence)
Recommended Name: Clustered mitochondria protein homolog  
Size: 1309 amino acids; 146670 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AK023003; Type=Frameshift; Positions=1105; Sequence=AK125717; Type=Frameshift;
Positions=875; Sequence=CAH10532.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6AHY2 Q6P3X7 Q6ZUG8 Q8N4U7 Q9BTA3 Q9H979

Explore the universe of human proteins at neXtProt for CLUH: NX_O75153

Explore proteomics data for CLUH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75153

  • CLUH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLUH Protein Expression
    REFSEQ proteins: NP_056044.3  
    ENSEMBL proteins: 
     ENSP00000458986   ENSP00000464732   ENSP00000459540   ENSP00000461126   ENSP00000460101  
     ENSP00000458241   ENSP00000460173   ENSP00000460293   ENSP00000388872   ENSP00000439628  

    Human Recombinant Protein Products for CLUH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CLUH
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLUH
    GenScript Custom Purified and Recombinant Proteins Services for CLUH
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    CLUH for ontologies           About GeneDecksing



    CLUH Antibody Products: 
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    Novus Biologicals CLUH Antibodies
    Abcam antibodies for CLUH
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CLUH
    LSBio Antibodies in human, mouse, rat for CLUH 

    Assay Products for CLUH: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR025697 CLU_dom
     IPR027523 CLU
     IPR023231 GSKIP/TIF31_domain

    Graphical View of Domain Structure for InterPro Entry O75153

    ProtoNet protein and cluster: O75153

    UniProtKB/Swiss-Prot: CLU_HUMAN, O75153
    Similarity: Belongs to the CLU family
    Similarity: Contains 4 TPR repeats


    CLUH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLU_HUMAN, O75153
    Function: Involved in proper cytoplasmic distribution of mitochondria (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for CLUH:

     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLUH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLUH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLUH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLUH 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLUH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLUH
    SwitchGear 3'UTR luciferase reporter plasmidCLUH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLUH
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLUH

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLUH (see all 6)
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    GenScript Custom all cDNA clones Services for CLUH
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLUH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUH
    Sirion Biotech Customized lentivirus for stable overexpression of CLUH 
                         Customized lentivirus expression plasmids for stable overexpression of CLUH 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLUH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLUH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translation Factors
    Translation Factors


    1 BioSystems Pathway for CLUH
        Translation Factors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLUH

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/239 Interacting proteins for CLUH (O751533 ENSP000003888724) via UniProtKB, MINT, STRING, and/or I2D (see all 239)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048312intracellular distribution of mitochondria IEA--

    CLUH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLUH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLUH (CLU)

    9 Novoseek inferred chemical compound relationships for CLUH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiosemicarbazide 73.7 6 8995409 (3), 15567442 (1), 15685555 (1)
    cdcl2 45.2 4 18837298 (2), 17096938 (1)
    gtp 26.4 2 20132446 (1), 15601822 (1)
    adenylate 11.7 4 15059963 (1), 15567442 (1), 16913227 (1)
    sucrose 7.56 1 16215987 (1)
    cadmium 1.58 1 17096938 (1)
    oligonucleotide 0 1 15703437 (1)
    tyrosine 0 2 8816444 (2)
    arginine 0 2 8816444 (2)

    Search CenterWatch for drugs/clinical trials and news about CLUH / CLU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLUH gene: 
    NM_015229.3  

    Unigene Cluster for CLUH:

    Clustered mitochondria (cluA/CLU1) homolog
    Hs.22616  [show with all ESTs]
    Unigene Representative Sequence: NM_015229
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570628 ENST00000575014(uc002fux.1 uc010ckc.1) ENST00000574210
    ENST00000574426 ENST00000572014 ENST00000574166 ENST00000573641 ENST00000575624
    ENST00000572129 ENST00000571539 ENST00000576885 ENST00000572414 ENST00000576309
    ENST00000571566 ENST00000435359(uc002fuy.1) ENST00000538975
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLUH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLUH
    SwitchGear 3'UTR luciferase reporter plasmidCLUH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLUH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLUH
    Clone
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    OriGene clones in human, mouse for CLUH (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CLUH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLUH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUH
    Sirion Biotech Customized lentivirus for stable overexpression of CLUH 
                         Customized lentivirus expression plasmids for stable overexpression of CLUH 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLUH
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CLUH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLUH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLUH

    Additional mRNA sequence: 

    AB014564.1 AK023003.1 AK074252.1 AK093541.1 AK125717.1 AK308854.1 BC004266.1 BC033614.1 
    BC063786.1 BX648864.1 CR627449.1 

    10 DOTS entries:

    DT.100651309  DT.112730  DT.100059900  DT.86858797  DT.120981731  DT.95188256  DT.99951028  DT.120981742 
    DT.95188257  DT.99952085 

    24/241 AceView cDNA sequences (see all 241):

    BQ899052 BM824520 BQ061079 CR598422 BM797169 AU125504 CA424065 AI658739 
    BC004266 CA314687 BQ182717 CA306964 AI363909 AK023003 AK074252 BX485771 
    BU191522 BC033614 CA426859 CR590286 AB014564 BI857197 AI355242 BM826371 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CLUH (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                              -     -     -     -                           
    SP2:                                                                                                              -     -     -     -                           
    SP3:                                                                                                                    -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
    SP1:                                                  -     -                           
    SP2:                                                  -     -                           
    SP3:  -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CLUH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLUH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLUH Expression
    About this image


    See CLUH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLUH

    SOURCE GeneReport for Unigene cluster: Hs.22616
        SABiosciences Custom PCR Arrays for CLUH
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLUH gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cluh5
    1300001I01Rik1
    RIKEN cDNA 1300001I01 gene1, 5 88.16(n)1
    95.63(a)1
      11 (45.76 cM)5
    741481  NM_001081158.21  NP_001074627.11 
     746494955 
    chicken
    (Gallus gallus)
    Aves KIAA06641 KIAA0664 75.89(n)
    86.12(a)
      417675  XM_415920.3  XP_415920.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLUH6
    clustered mitochondria (cluA/CLU1) homolog
    82(a)
    1 ↔ 1
    GL343731.1(88729-171224)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.183062 Transcribed sequence with moderate similarity to protein more 75.3(n)    BX759848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb4982 sbcb498 82.01(n)   321281  BI885903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta clu1 clueless 61.21(n)
    56.79(a)
      36793  NM_137251.2  NP_611095.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clu-11 Protein CLU-1 48.62(n)
    43.94(a)
      176341  NM_066696.4  NP_499097.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLU16
    eIF3 component of unknown function; deletion cause...
    21(a)
    1 ↔ 1
    XIII(291134-294967)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G521401 tetratricopeptide repeat (TPR)-containing protein 43.02(n)
    34.22(a)
      824378  NM_001203137.1  NP_001190066.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07174001 hypothetical protein 42.08(n)
    33.75(a)
      4330529  NM_001054467.1  NP_001047932.1 


    ENSEMBL Gene Tree for CLUH (if available)
    TreeFam Gene Tree for CLUH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLUH gene

    CLUH for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for CLUH (see all 11)
    PGOHUM00000238661 PGOHUM00000239741 PGOHUM00000248540 PGOHUM00000262325 PGOHUM00000249062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/718 SNPs in CLUH are shown (see all 718)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919213391,2
    --2592235(+) TGTCCA/GAGGGT 1 -- int10--------
    rs1388443191,2
    C--2592244(+) GTGGCA/GAACTT 1 -- int10--------
    rs1488769591,2
    C--2592302(+) CCACCC/TTCCTT 1 -- int10--------
    rs1435353931,2
    C--2592368(+) CCTCAC/TGGGTC 1 -- int10--------
    rs1168783191,2
    F--2592409(+) AGCACC/TCCTCC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1480642301,2
    --2592444(+) TGCACC/GTGGTG 1 -- int10--------
    rs1418060281,2
    --2592473(+) CACGAC/GACTCC 1 -- int10--------
    rs1831847131,2
    --2592534(+) GTGATC/TCCACC 1 -- int10--------
    rs1874412421,2
    --2592576(+) CGTGAC/TCTCGA 1 -- int10--------
    rs96356781,2
    C,H--2592600(+) TGTATC/ATATTC 1 -- int16Minor allele frequency- A:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for CLUH (2592680 - 2615957 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLUH: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLUH
    DNA2.0 Custom Variant and Variant Library Synthesis for CLUH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    8 diseases for CLUH:    About MalaCards
    measles    hepatitis c    herpes simplex    prostate cancer
    pancreatic cancer    hepatitis    pancreatitis    prostatitis


    CLUH for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CLUH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 16.3 4 15685555 (1), 15272411 (1), 15563596 (1), 18599441 (1)
    shock 0 2 10859165 (1)
    prostate cancer 0 1 10362802 (1)
    cancer 0 1 17918192 (1)


    Export disorders for CLUH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLUH gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with CLUH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    4. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23277 HGNC: 29094 AceView: KIAA0664 Ensembl:ENSG00000132361 euGenes: HUgn23277
    ECgene: CLUH H-InvDB: CLUH

    (According to HUGE)
    About This Section
    HUGE: KIAA0664

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLUH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLUH gene:
    Search GeneIP for patents involving CLUH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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