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Aliases for CLUH Gene

Aliases for CLUH Gene

  • Clustered Mitochondria (CluA/CLU1) Homolog 2 3 5
  • KIAA0664 2 3 4
  • CLU1 3

External Ids for CLUH Gene

Previous HGNC Symbols for CLUH Gene

  • KIAA0664

Previous GeneCards Identifiers for CLUH Gene

  • GC17M002593

Summaries for CLUH Gene

GeneCards Summary for CLUH Gene

CLUH (Clustered Mitochondria (CluA/CLU1) Homolog) is a Protein Coding gene. Among its related pathways are Translation Factors. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for CLUH Gene

  • mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUH Gene

Genomics for CLUH Gene

Regulatory Elements for CLUH Gene

Enhancers for CLUH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLUH on UCSC Golden Path with GeneCards custom track

Promoters for CLUH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLUH on UCSC Golden Path with GeneCards custom track

Genomic Location for CLUH Gene

Chromosome:
17
Start:
2,689,386 bp from pter
End:
2,712,663 bp from pter
Size:
23,278 bases
Orientation:
Minus strand

Genomic View for CLUH Gene

Genes around CLUH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUH Gene

Proteins for CLUH Gene

  • Protein details for CLUH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75153-CLU_HUMAN
    Recommended name:
    Clustered mitochondria protein homolog
    Protein Accession:
    O75153
    Secondary Accessions:
    • Q6AHY2
    • Q6P3X7
    • Q6ZUG8
    • Q8N4U7
    • Q9BTA3
    • Q9H979

    Protein attributes for CLUH Gene

    Size:
    1309 amino acids
    Molecular mass:
    146670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK023003; Type=Frameshift; Positions=1105; Evidence={ECO:0000305}; Sequence=AK125717; Type=Frameshift; Positions=875; Evidence={ECO:0000305}; Sequence=CAH10532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CLUH Gene

Proteomics data for CLUH Gene at MOPED

Post-translational modifications for CLUH Gene

  • Ubiquitination at Lys 974
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUH Gene

Domains & Families for CLUH Gene

Protein Domains for CLUH Gene

Suggested Antigen Peptide Sequences for CLUH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75153

UniProtKB/Swiss-Prot:

CLU_HUMAN :
  • Belongs to the CLU family.
  • Contains 4 TPR repeats.
Family:
  • Belongs to the CLU family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with CLUH: view

No data available for Gene Families for CLUH Gene

Function for CLUH Gene

Molecular function for CLUH Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.
genes like me logo Genes that share phenotypes with CLUH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLUH Gene

Localization for CLUH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUH Gene

Cytoplasm. Cytoplasmic granule. Note=A fraction colocalizes with tyrosinated tubulin and can be detected close to mitochondria. {ECO:0000269 PubMed:25349259}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CLUH Gene

Pathways & Interactions for CLUH Gene

SuperPathways for CLUH Gene

Superpath Contained pathways
1 Translation Factors
genes like me logo Genes that share pathways with CLUH: view

Pathways by source for CLUH Gene

1 BioSystems pathway for CLUH Gene

Gene Ontology (GO) - Biological Process for CLUH Gene

None

No data available for SIGNOR curated interactions for CLUH Gene

Drugs & Compounds for CLUH Gene

(3) Drugs for CLUH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CLUH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLUH: view

Transcripts for CLUH Gene

Unigene Clusters for CLUH Gene

Clustered mitochondria (cluA/CLU1) homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLUH Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:

ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CLUH Gene

GeneLoc Exon Structure for
CLUH
ECgene alternative splicing isoforms for
CLUH

Expression for CLUH Gene

mRNA expression in normal human tissues for CLUH Gene

mRNA differential expression in normal tissues according to GTEx for CLUH Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for CLUH Gene

This gene is overexpressed in Breast (22.6), Adrenal (8.8), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLUH Gene



SOURCE GeneReport for Unigene cluster for CLUH Gene Hs.22616

genes like me logo Genes that share expression patterns with CLUH: view

Protein tissue co-expression partners for CLUH Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CLUH Gene

Orthologs for CLUH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLUH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA0664 35
  • 91.24 (n)
  • 95.42 (a)
CLUH 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0664 35
  • 90.52 (n)
  • 95.57 (a)
CLUH 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cluh 35
  • 88.16 (n)
  • 95.63 (a)
Cluh 16
Cluh 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA0664 35
  • 98.15 (n)
  • 98.12 (a)
CLUH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cluh 35
  • 87.98 (n)
  • 95.11 (a)
oppossum
(Monodelphis domestica)
Mammalia CLUH 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA0664 35
  • 76.4 (n)
  • 86.7 (a)
CLUH 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLUH 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cluh 35
  • 71.64 (n)
  • 80.59 (a)
Str.18306 35
zebrafish
(Danio rerio)
Actinopterygii cluha 35
  • 73.75 (n)
  • 80.88 (a)
sbcb498 35
CLUH (3 of 3) 36
  • 35 (a)
OneToMany
cluha 36
  • 72 (a)
OneToMany
cluhb 36
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta K0664_ANOGA 35
  • 66.53 (n)
  • 61.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta clu 35
  • 60.9 (n)
  • 56.51 (a)
clu 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clu-1 35
  • 48.72 (n)
  • 44.66 (a)
clu-1 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLU1 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52140 35
  • 43.12 (n)
  • 34.31 (a)
rice
(Oryza sativa)
Liliopsida Os02g0717400 35
  • 42.41 (n)
  • 34.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4098 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00021 35
  • 49.18 (n)
  • 33.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC530.06c 35
  • 39.3 (n)
  • 32.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for CLUH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLUH Gene

ENSEMBL:
Gene Tree for CLUH (if available)
TreeFam:
Gene Tree for CLUH (if available)

Paralogs for CLUH Gene

genes like me logo Genes that share paralogs with CLUH: view

No data available for Paralogs for CLUH Gene

Variants for CLUH Gene

Sequence variations from dbSNP and Humsavar for CLUH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11078312 - 2,696,892(-) GAACG(C/T)CAGCC reference, missense
rs1003398 -- 2,695,333(+) CCCAG(A/C/G/T)CCCAC intron-variant
rs1003399 -- 2,695,345(+) GCTCC(A/C/G)GTTCC intron-variant
rs737423 -- 2,700,986(+) TGCTG(A/T)CTCGG intron-variant
rs1065479 -- 2,703,421(+) CAGGT(A/G)CGGTG reference, synonymous-codon

Variation tolerance for CLUH Gene

Residual Variation Intolerance Score: 4.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CLUH Gene

Disorders for CLUH Gene

Relevant External Links for CLUH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLUH

No disorders were found for CLUH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLUH Gene

Publications for CLUH Gene

  1. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear- encoded mitochondrial proteins. (PMID: 25349259) Gao J. … Rugarli E.I. (J. Cell Biol. 2014) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for CLUH Gene

Sources for CLUH Gene

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