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CLUH Gene

protein-coding   GIFtS: 44
GCID: GC17M002593

Clustered Mitochondria (CluA/CLU1) Homolog

(Previous name: KIAA0664)
(Previous symbol: KIAA0664)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Clustered Mitochondria (CluA/CLU1) Homolog1 2
KIAA06641 2 3
CLU12
Clustered Mitochondria Protein Homolog2

External Ids:    HGNC: 290941   Entrez Gene: 232772   Ensembl: ENSG000001323617   UniProtKB: O751533   

Export aliases for CLUH gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLUH Gene:
CLUH (clustered mitochondria (cluA/CLU1) homolog) is a protein-coding gene.

UniProtKB/Swiss-Prot: CLU_HUMAN, O75153
Function: Involved in proper cytoplasmic distribution of mitochondria (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CLUH
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLUH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLUH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

CLUH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLUH gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002593:  view genomic region     (about GC identifiers)

Start:
2,592,680 bp from pter      End:
2,615,957 bp from pter
Size:
23,278 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLU_HUMAN, O75153 (See protein sequence)
Recommended Name: Clustered mitochondria protein homolog  
Size: 1309 amino acids; 146670 Da
Sequence caution: Sequence=AK023003; Type=Frameshift; Positions=1105; Sequence=AK125717; Type=Frameshift;
Positions=875; Sequence=CAH10532.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6AHY2 Q6P3X7 Q6ZUG8 Q8N4U7 Q9BTA3 Q9H979

Explore the universe of human proteins at neXtProt for CLUH: NX_O75153

Explore proteomics data for CLUH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys974
  • Modification sites at PhosphoSitePlus

  • See CLUH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056044.3  
    ENSEMBL proteins: 
     ENSP00000458986   ENSP00000464732   ENSP00000459540   ENSP00000461126   ENSP00000460101  
     ENSP00000460173   ENSP00000460293   ENSP00000388872   ENSP00000439628  

    CLUH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CLUH
    OriGene Protein Over-expression Lysate for CLUH
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CLUH
    GenScript Custom Purified and Recombinant Proteins Services for CLUH
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CLUH 

    CLUH Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLUH
    Novus Biologicals CLUH Antibodies
    Search for Antibodies for CLUH at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CLUH
    LSBio Antibodies in human, mouse, rat for CLUH

    CLUH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLUH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLUH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CLUH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR028275 CLU_N
     IPR025697 CLU_dom
     IPR027523 CLU
     IPR023231 GSKIP_dom

    Graphical View of Domain Structure for InterPro Entry O75153

    ProtoNet protein and cluster: O75153

    UniProtKB/Swiss-Prot: CLU_HUMAN, O75153
    Similarity: Belongs to the CLU family
    Similarity: Contains 4 TPR repeats


    Find genes that share domains with CLUH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLU_HUMAN, O75153
    Function: Involved in proper cytoplasmic distribution of mitochondria (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for CLUH:

     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLUH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLUH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLUH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLUH

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLUH:
    hsa-mir-320a (MIRT044519), hsa-mir-98-5p (MIRT027779), hsa-let-7b-5p (MIRT032441), hsa-mir-16-5p (MIRT031896), hsa-mir-484 (MIRT042007), hsa-mir-744-5p (MIRT037649)

    Block miRNA regulation of human, mouse, rat CLUH using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLUH
    SwitchGear 3'UTR luciferase reporter plasmidCLUH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLUH
    Predesigned siRNA for gene silencing in human, mouse, rat CLUH

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CLUH

    Clone
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    OriGene clones in human, mouse for CLUH (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CLUH
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLUH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUH

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CLUH
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLUH 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLU_HUMAN, O75153: Cytoplasm (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CLUH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLUH About    
    See pathways by source

    SuperPathContained pathways About
    1Translation Factors
    Translation Factors


    1 BioSystems Pathway for CLUH
        Translation Factors


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLUH
    Interactions:

        Search GeneGlobe Interaction Network for CLUH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLUH (O751533 ENSP000003888724) via UniProtKB, MINT, STRING, and/or I2D (see all 326)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048312intracellular distribution of mitochondria IEA--

    Find genes that share ontologies with CLUH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLUH (CLU)

    9 Novoseek inferred chemical compound relationships for CLUH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiosemicarbazide 73.7 6 8995409 (3), 15567442 (1), 15685555 (1)
    cdcl2 45.2 4 18837298 (2), 17096938 (1)
    gtp 26.4 2 20132446 (1), 15601822 (1)
    adenylate 11.7 4 15059963 (1), 15567442 (1), 16913227 (1)
    sucrose 7.56 1 16215987 (1)
    cadmium 1.58 1 17096938 (1)
    oligonucleotide 0 1 15703437 (1)
    tyrosine 0 2 8816444 (2)
    arginine 0 2 8816444 (2)



    Find genes that share compounds with CLUH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLUH gene: 
    NM_015229.3  

    Unigene Cluster for CLUH:

    Clustered mitochondria (cluA/CLU1) homolog
    Hs.22616  [show with all ESTs]
    Unigene Representative Sequence: NM_015229
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570628 ENST00000575014(uc002fux.1 uc010ckc.1) ENST00000574210
    ENST00000574426 ENST00000572014 ENST00000574166 ENST00000573641 ENST00000575624
    ENST00000572129 ENST00000571539 ENST00000576885 ENST00000576309 ENST00000571566
    ENST00000435359(uc002fuy.1) ENST00000538975
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLUH using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CLUH
    SwitchGear 3'UTR luciferase reporter plasmidCLUH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLUH
    Predesigned siRNA for gene silencing in human, mouse, rat CLUH
    Clone
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    OriGene clones in human, mouse for CLUH (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CLUH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLUH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLUH
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLUH
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CLUH
      QuantiTect SYBR Green Assays in human, mouse, rat CLUH
      QuantiFast Probe-based Assays in human, mouse, rat CLUH

    Additional mRNA sequence: 

    AB014564.1 AK023003.1 AK074252.1 AK093541.1 AK125717.1 AK308854.1 BC004266.1 BC033614.1 
    BC063786.1 BX648864.1 CR627449.1 

    10 DOTS entries:

    DT.100651309  DT.112730  DT.100059900  DT.86858797  DT.120981731  DT.95188256  DT.99951028  DT.120981742 
    DT.95188257  DT.99952085 

    Selected AceView cDNA sequences (see all 241):

    AI355242 AU129227 BM824520 BI857197 AI363909 AA290645 AW188206 BU729017 
    BU948422 BC033614 BX485771 AU125504 BF592063 BX110563 BF058644 AK074252 
    AB014564 CD672798 CA426859 CA306964 AI459132 BU191522 T07988 BQ899052 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLUH (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                              -     -     -     -                           
    SP2:                                                                                                              -     -     -     -                           
    SP3:                                                                                                                    -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
    SP1:                                                  -     -                           
    SP2:                                                  -     -                           
    SP3:  -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CLUH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLUH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLUH Expression
    About this image

    CLUH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLUH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22616
        Custom PCR Arrays for CLUH
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CLUH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLUH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLUH gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cluh1 , 5 RIKEN cDNA 1300001I01 gene5
    clustered mitochondria (cluA/CLU1) homolog1
    88.16(n)1
    95.63(a)1
      11 (45.76 cM)5
    741481  NM_001081158.21  NP_001074627.11 
     746494955 
    chicken
    (Gallus gallus)
    Aves KIAA06641 KIAA0664 76.4(n)
    86.7(a)
      417675  XM_415920.4  XP_415920.4 
    lizard
    (Anolis carolinensis)
    Reptilia CLUH6
    clustered mitochondria (cluA/CLU1) homolog
    82(a)
    1 ↔ 1
    GL343731.1(88729-171224)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.183062 Transcribed sequence with moderate similarity to protein more 75.3(n)    BX759848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb4982 sbcb498 82.01(n)   321281  BI885903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta clu1 clueless 60.9(n)
    56.51(a)
      36793  NM_137251.3  NP_611095.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clu-11 clu-1 48.72(n)
    44.66(a)
      176341  NM_066696.5  NP_499097.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLU16
    eIF3 component of unknown function; deletion cause...
    21(a)
    1 ↔ 1
    XIII(291134-294967) YMR012W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G521401 AT3G52140 43.12(n)
    34.31(a)
      824378  NM_001203137.1  NP_001190066.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07174001 Os02g0717400 42.41(n)
    34.32(a)
      4330529  NM_001054467.1  NP_001047932.1 


    ENSEMBL Gene Tree for CLUH (if available)
    TreeFam Gene Tree for CLUH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLUH gene

    Find genes that share paralogs with CLUH           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CLUH (see all 11)
    PGOHUM00000238661 PGOHUM00000239741 PGOHUM00000248540 PGOHUM00000262325 PGOHUM00000249062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLUH (see all 718)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919213391,2
    --2592235(+) TGTCCA/GAGGGT 1 -- int10--------
    rs1388443191,2
    C--2592244(+) GTGGCA/GAACTT 1 -- int10--------
    rs1488769591,2
    C--2592302(+) CCACCC/TTCCTT 1 -- int10--------
    rs1435353931,2
    C--2592368(+) CCTCAC/TGGGTC 1 -- int10--------
    rs1168783191,2
    F--2592409(+) AGCACC/TCCTCC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1480642301,2
    --2592444(+) TGCACC/GTGGTG 1 -- int10--------
    rs1418060281,2
    --2592473(+) CACGAC/GACTCC 1 -- int10--------
    rs1831847131,2
    --2592534(+) GTGATC/TCCACC 1 -- int10--------
    rs1874412421,2
    --2592576(+) CGTGAC/TCTCGA 1 -- int10--------
    rs96356781,2
    C,H--2592600(+) TGTATC/ATATTC 1 -- int16Minor allele frequency- A:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for CLUH (2592680 - 2615957 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLUH: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLUH
    DNA2.0 Custom Variant and Variant Library Synthesis for CLUH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CLUH           About GenesLikeMe

    4 Novoseek inferred disease relationships for CLUH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 16.3 4 15685555 (1), 15272411 (1), 15563596 (1), 18599441 (1)
    shock 0 2 10859165 (1)
    prostate cancer 0 1 10362802 (1)
    cancer 0 1 17918192 (1)


    Export disorders for CLUH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLUH gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with CLUH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    4. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    5. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23277 HGNC: 29094 AceView: KIAA0664 Ensembl:ENSG00000132361 euGenes: HUgn23277
    ECgene: CLUH H-InvDB: CLUH

    (According to HUGE)
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    HUGE: KIAA0664

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLUH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLUH gene:
    Search GeneIP for patents involving CLUH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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