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Aliases for CLUH Gene

Aliases for CLUH Gene

  • Clustered Mitochondria (CluA/CLU1) Homolog 2 3
  • KIAA0664 2 3 4
  • Clustered Mitochondria Protein Homolog 3
  • CLU1 3

External Ids for CLUH Gene

Previous Symbols for CLUH Gene

  • KIAA0664

Summaries for CLUH Gene

GeneCards Summary for CLUH Gene

CLUH (Clustered Mitochondria (CluA/CLU1) Homolog) is a Protein Coding gene. Among its related pathways are Translation Factors.

UniProtKB/Swiss-Prot for CLUH Gene

  • mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUH Gene

Genomics for CLUH Gene

Genomic Location for CLUH Gene

Start:
2,689,386 bp from pter
End:
2,712,663 bp from pter
Size:
23,278 bases
Orientation:
Minus strand

Genomic View for CLUH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLUH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUH Gene

No data available for Regulatory Elements for CLUH Gene

Proteins for CLUH Gene

  • Protein details for CLUH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75153-CLU_HUMAN
    Recommended name:
    Clustered mitochondria protein homolog
    Protein Accession:
    O75153
    Secondary Accessions:
    • Q6AHY2
    • Q6P3X7
    • Q6ZUG8
    • Q8N4U7
    • Q9BTA3
    • Q9H979

    Protein attributes for CLUH Gene

    Size:
    1309 amino acids
    Molecular mass:
    146670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK023003; Type=Frameshift; Positions=1105; Evidence={ECO:0000305}; Sequence=AK125717; Type=Frameshift; Positions=875; Evidence={ECO:0000305}; Sequence=CAH10532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CLUH Gene

Proteomics data for CLUH Gene at MOPED

Post-translational modifications for CLUH Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys974

No data available for DME Specific Peptides for CLUH Gene

Domains for CLUH Gene

Protein Domains for CLUH Gene

UniProtKB/Swiss-Prot:

CLU_HUMAN
Family:
  • Belongs to the CLU family.:
    • O75153
Similarity:
  • Contains 4 TPR repeats.:
    • O75153
genes like me logo Genes that share domains with CLUH: view

No data available for Gene Families for CLUH Gene

Function for CLUH Gene

Molecular function for CLUH Gene

UniProtKB/Swiss-Prot Function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

Gene Ontology (GO) - Molecular Function for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 25349259
genes like me logo Genes that share ontologies with CLUH: view

Phenotypes for CLUH Gene

genes like me logo Genes that share phenotypes with CLUH: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLUH Gene

Localization for CLUH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUH Gene

Cytoplasm. Cytoplasmic granule. Note=A fraction colocalizes with tyrosinated tubulin and can be detected close to mitochondria. {ECO:0000269 PubMed:25349259}.

Gene Ontology (GO) - Cellular Components for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25349259
genes like me logo Genes that share ontologies with CLUH: view

Pathways for CLUH Gene

SuperPathways for CLUH Gene

Superpath Contained pathways
1 Translation Factors
genes like me logo Genes that share pathways with CLUH: view

Pathways by source for CLUH Gene

1 BioSystems pathway for CLUH Gene

Gene Ontology (GO) - Biological Process for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 25349259
GO:0048312 intracellular distribution of mitochondria IMP 25349259
genes like me logo Genes that share ontologies with CLUH: view

Compounds for CLUH Gene

(9) Novoseek inferred chemical compound relationships for CLUH Gene

Compound -log(P) Hits PubMed IDs
thiosemicarbazide 73.7 5
cdcl2 45.2 3
gtp 26.4 2
adenylate 11.7 3
sucrose 7.56 1
genes like me logo Genes that share compounds with CLUH: view

Transcripts for CLUH Gene

Unigene Clusters for CLUH Gene

Clustered mitochondria (cluA/CLU1) homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLUH Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:

ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CLUH Gene

GeneLoc Exon Structure for
CLUH
ECgene alternative splicing isoforms for
CLUH

Expression for CLUH Gene

mRNA expression in normal human tissues for CLUH Gene

mRNA differential expression in normal tissues according to GTEx for CLUH Gene

This gene is overexpressed in Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLUH Gene

SOURCE GeneReport for Unigene cluster for CLUH Gene Hs.22616

genes like me logo Genes that share expressions with CLUH: view

Orthologs for CLUH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLUH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUH 37
  • 99 (a)
OneToOne
KIAA0664 36
  • 98.15 (n)
  • 98.12 (a)
cow
(Bos Taurus)
Mammalia CLUH 37
  • 95 (a)
OneToOne
KIAA0664 36
  • 91.24 (n)
  • 95.42 (a)
dog
(Canis familiaris)
Mammalia CLUH 37
  • 93 (a)
OneToOne
KIAA0664 36
  • 90.52 (n)
  • 95.57 (a)
mouse
(Mus musculus)
Mammalia Cluh 36
  • 88.16 (n)
  • 95.63 (a)
Cluh 16
Cluh 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLUH 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cluh 36
  • 87.98 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves CLUH 37
  • 82 (a)
OneToOne
KIAA0664 36
  • 76.4 (n)
  • 86.7 (a)
lizard
(Anolis carolinensis)
Reptilia CLUH 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cluh 36
  • 71.64 (n)
  • 80.59 (a)
Str.18306 36
zebrafish
(Danio rerio)
Actinopterygii CLUH (3 of 3) 37
  • 35 (a)
OneToMany
cluha 36
  • 73.75 (n)
  • 80.88 (a)
cluha 37
  • 72 (a)
OneToMany
cluhb 37
  • 45 (a)
OneToMany
sbcb498 36
African malaria mosquito
(Anopheles gambiae)
Insecta K0664_ANOGA 36
  • 66.53 (n)
  • 61.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta clu 36
  • 60.9 (n)
  • 56.51 (a)
clu 37
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clu-1 36
  • 48.72 (n)
  • 44.66 (a)
clu-1 37
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLU1 37
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52140 36
  • 43.12 (n)
  • 34.31 (a)
rice
(Oryza sativa)
Liliopsida Os02g0717400 36
  • 42.41 (n)
  • 34.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00021 36
  • 49.18 (n)
  • 33.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC530.06c 36
  • 39.3 (n)
  • 32.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4098 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
OneToOne
Species with no ortholog for CLUH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLUH Gene

ENSEMBL:
Gene Tree for CLUH (if available)
TreeFam:
Gene Tree for CLUH (if available)

Paralogs for CLUH Gene

genes like me logo Genes that share paralogs with CLUH: view

No data available for Paralogs for CLUH Gene

Variants for CLUH Gene

Sequence variations from dbSNP and Humsavar for CLUH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs734957 -- 2,709,290(+) GTCCC(A/C/G)GGAGC intron-variant, upstream-variant-2KB
rs737423 -- 2,700,986(+) TGCTG(A/T)CTCGG intron-variant
rs758417 -- 2,701,081(+) TGGGC(C/T)GGCTC intron-variant
rs758418 -- 2,709,105(+) GGAGC(C/T)CAAAG intron-variant, upstream-variant-2KB
rs1003398 -- 2,695,333(+) CCCAG(C/T)CCCAC intron-variant

Relevant External Links for CLUH Gene

HapMap Linkage Disequilibrium report
CLUH

No data available for Structural Variations from Database of Genomic Variants (DGV) for CLUH Gene

Disorders for CLUH Gene

(4) Novoseek inferred disease relationships for CLUH Gene

Disease -log(P) Hits PubMed IDs
hepatitis c 16.3 4
shock 0 1
prostate cancer 0 1
cancer 0 1
genes like me logo Genes that share disorders with CLUH: view

No data available for UniProtKB/Swiss-Prot for CLUH Gene

Publications for CLUH Gene

  1. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear- encoded mitochondrial proteins. (PMID: 25349259) Gao J. … Rugarli E.I. (J. Cell Biol. 2014) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for CLUH Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CLUH
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CLUH
    • Block miRNA regulation of CLUH using miScript Target Protectors

    Sources for CLUH Gene

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