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Aliases for CLUH Gene

Aliases for CLUH Gene

  • Clustered Mitochondria Homolog 2 3 5
  • KIAA0664 2 3 4
  • Clustered Mitochondria (CluA/CLU1) Homolog 2 3
  • Clustered Mitochondria Protein Homolog 3
  • CLU1 3

External Ids for CLUH Gene

Previous HGNC Symbols for CLUH Gene

  • KIAA0664

Previous GeneCards Identifiers for CLUH Gene

  • GC17M002593

Summaries for CLUH Gene

GeneCards Summary for CLUH Gene

CLUH (Clustered Mitochondria Homolog) is a Protein Coding gene. Among its related pathways are Translation Factors. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for CLUH Gene

  • mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUH Gene

Genomics for CLUH Gene

Regulatory Elements for CLUH Gene

Enhancers for CLUH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G002592 1 ENCODE 11.3 +118.3 118273 3.6 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 CLUH METTL16 LOC105371490 PAFAH1B1 GC17P002608 GC17P002607
GH17G002756 0.9 ENCODE 11.2 -43.8 -43753 0.8 ZNF76 ZNF2 GLIS2 KLF7 EGR2 ZNF263 ZNF362 ZEB2 ZNF398 SREBF1 CLUH RAP1GAP2 GC17M002839
GH17G002633 0.9 ENCODE 11.1 +78.0 77954 2.0 TBP PKNOX1 ZFP64 ZNF133 INSM2 FEZF1 RAD21 ZNF121 POLR3A ZNF366 METTL16 CLUH ENSG00000263345 LOC105371490 ENSG00000279432 SAMD11P1
GH17G002755 0.8 ENCODE 11.2 -42.7 -42739 0.2 KLF1 KLF17 ZNF2 E2F1 ZFHX2 POLR2A ZBTB48 PATZ1 ZNF600 KLF7 CLUH GC17P002753 RAP1GAP2
GH17G002602 0.8 ENCODE 11.1 +109.9 109925 0.8 FOXA2 INSM2 KLF17 FEZF1 ZNF121 ZNF362 OVOL3 TSHZ1 ZEB2 ZNF623 CLUH GC17P002608 GC17P002607 PAFAH1B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLUH on UCSC Golden Path with GeneCards custom track

Promoters for CLUH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090267 1063 1601 HDGF CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for CLUH Gene

Chromosome:
17
Start:
2,689,386 bp from pter
End:
2,712,663 bp from pter
Size:
23,278 bases
Orientation:
Minus strand

Genomic View for CLUH Gene

Genes around CLUH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUH Gene

Proteins for CLUH Gene

  • Protein details for CLUH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75153-CLU_HUMAN
    Recommended name:
    Clustered mitochondria protein homolog
    Protein Accession:
    O75153
    Secondary Accessions:
    • Q6AHY2
    • Q6P3X7
    • Q6ZUG8
    • Q8N4U7
    • Q9BTA3
    • Q9H979

    Protein attributes for CLUH Gene

    Size:
    1309 amino acids
    Molecular mass:
    146670 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK023003; Type=Frameshift; Positions=1105; Evidence={ECO:0000305}; Sequence=AK125717; Type=Frameshift; Positions=875; Evidence={ECO:0000305}; Sequence=CAH10532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CLUH Gene

Post-translational modifications for CLUH Gene

  • Ubiquitination at posLast=974974
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLUH Gene

Domains & Families for CLUH Gene

Suggested Antigen Peptide Sequences for CLUH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75153

UniProtKB/Swiss-Prot:

CLU_HUMAN :
  • Belongs to the CLU family.
Family:
  • Belongs to the CLU family.
genes like me logo Genes that share domains with CLUH: view

No data available for Gene Families for CLUH Gene

Function for CLUH Gene

Molecular function for CLUH Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

Gene Ontology (GO) - Molecular Function for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 25349259
genes like me logo Genes that share ontologies with CLUH: view
genes like me logo Genes that share phenotypes with CLUH: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLUH Gene

Localization for CLUH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUH Gene

Cytoplasm. Cytoplasmic granule. Note=A fraction colocalizes with tyrosinated tubulin and can be detected close to mitochondria. {ECO:0000269 PubMed:25349259}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLUH gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25349259
genes like me logo Genes that share ontologies with CLUH: view

Pathways & Interactions for CLUH Gene

SuperPathway Contained pathways
1 Translation Factors
genes like me logo Genes that share pathways with CLUH: view

Pathways by source for CLUH Gene

1 BioSystems pathway for CLUH Gene

Gene Ontology (GO) - Biological Process for CLUH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 25349259
GO:0048312 intracellular distribution of mitochondria IMP 25349259
genes like me logo Genes that share ontologies with CLUH: view

No data available for SIGNOR curated interactions for CLUH Gene

Drugs & Compounds for CLUH Gene

(3) Drugs for CLUH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CLUH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLUH: view

Transcripts for CLUH Gene

Unigene Clusters for CLUH Gene

Clustered mitochondria (cluA/CLU1) homolog:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLUH Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:

ExUns: 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CLUH Gene

GeneLoc Exon Structure for
CLUH
ECgene alternative splicing isoforms for
CLUH

Expression for CLUH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLUH Gene

mRNA differential expression in normal tissues according to GTEx for CLUH Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for CLUH Gene

This gene is overexpressed in Breast (22.6), Adrenal (8.8), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLUH Gene



Protein tissue co-expression partners for CLUH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLUH Gene:

CLUH

SOURCE GeneReport for Unigene cluster for CLUH Gene:

Hs.22616

Evidence on tissue expression from TISSUES for CLUH Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CLUH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLUH Gene

Orthologs for CLUH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLUH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUH 35
  • 99 (a)
OneToOne
KIAA0664 34
  • 98.15 (n)
cow
(Bos Taurus)
Mammalia CLUH 35
  • 95 (a)
OneToOne
KIAA0664 34
  • 91.24 (n)
dog
(Canis familiaris)
Mammalia CLUH 35
  • 93 (a)
OneToOne
KIAA0664 34
  • 90.52 (n)
mouse
(Mus musculus)
Mammalia Cluh 34 16 35
  • 88.16 (n)
rat
(Rattus norvegicus)
Mammalia Cluh 34
  • 87.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CLUH 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLUH 35
  • 82 (a)
OneToOne
KIAA0664 34
  • 76.4 (n)
lizard
(Anolis carolinensis)
Reptilia CLUH 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cluh 34
  • 71.64 (n)
Str.18306 34
zebrafish
(Danio rerio)
Actinopterygii cluha 34 35
  • 73.75 (n)
cluhb 35
  • 45 (a)
OneToMany
CLUH (3 of 3) 35
  • 35 (a)
OneToMany
sbcb498 34
African malaria mosquito
(Anopheles gambiae)
Insecta K0664_ANOGA 34
  • 66.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta clu 34 35
  • 60.9 (n)
worm
(Caenorhabditis elegans)
Secernentea clu-1 34 35
  • 48.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLU1 35
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52140 34
  • 43.12 (n)
rice
(Oryza sativa)
Liliopsida Os02g0717400 34
  • 42.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00021 34
  • 49.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC530.06c 34
  • 39.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4098 34
Species where no ortholog for CLUH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLUH Gene

ENSEMBL:
Gene Tree for CLUH (if available)
TreeFam:
Gene Tree for CLUH (if available)

Paralogs for CLUH Gene

No data available for Paralogs for CLUH Gene

Variants for CLUH Gene

Sequence variations from dbSNP and Humsavar for CLUH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000035942 -- 2,713,393(+) GTTGC(A/G)GTGAG upstream-variant-2KB
rs1000085486 -- 2,707,903(+) ATGGG(C/T)CCCCA intron-variant, reference, synonymous-codon
rs1000086913 -- 2,704,321(+) CCAGC(A/G)GGCTC intron-variant
rs1000138141 -- 2,708,028(+) TCTCC(C/T)AGGGG intron-variant, utr-variant-5-prime
rs1000487920 -- 2,713,558(+) GTGTG(-/TATA)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLUH Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv2715504 CNV deletion 23290073
nsv1065489 CNV gain 25217958
nsv574225 CNV loss 21841781
nsv833339 CNV loss 17160897
nsv833340 CNV gain+loss 17160897
nsv952105 CNV deletion 24416366

Variation tolerance for CLUH Gene

Residual Variation Intolerance Score: 4.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLUH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLUH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLUH Gene

Disorders for CLUH Gene

Relevant External Links for CLUH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLUH

No disorders were found for CLUH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLUH Gene

Publications for CLUH Gene

  1. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear- encoded mitochondrial proteins. (PMID: 25349259) Gao J. … Rugarli E.I. (J. Cell Biol. 2014) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for CLUH Gene

Sources for CLUH Gene

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