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Aliases for CLUAP1 Gene

Aliases for CLUAP1 Gene

  • Clusterin Associated Protein 1 2 3 5
  • Cilia And Flagella Associated Protein 22 2 3
  • Qilin 3 4
  • Flagellar Associated Protein 22, Qilin-Like Protein, Homolog 3
  • Flagellar Associated Protein 22 2
  • Homolog (Chlamydomonas) 2
  • Qilin-Like Protein 2
  • KIAA0643 4
  • CFAP22 3
  • FAP22 3
  • IFT38 3

External Ids for CLUAP1 Gene

Previous GeneCards Identifiers for CLUAP1 Gene

  • GC16P003491
  • GC16P003550
  • GC16P003520

Summaries for CLUAP1 Gene

Entrez Gene Summary for CLUAP1 Gene

  • The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CLUAP1 Gene

CLUAP1 (Clusterin Associated Protein 1) is a Protein Coding gene. Diseases associated with CLUAP1 include oculoectodermal syndrome and leber hereditary optic neuropathy. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

UniProtKB/Swiss-Prot for CLUAP1 Gene

  • Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity).

Gene Wiki entry for CLUAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLUAP1 Gene

Genomics for CLUAP1 Gene

Regulatory Elements for CLUAP1 Gene

Promoters for CLUAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLUAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLUAP1 Gene

Chromosome:
16
Start:
3,500,924 bp from pter
End:
3,539,048 bp from pter
Size:
38,125 bases
Orientation:
Plus strand

Genomic View for CLUAP1 Gene

Genes around CLUAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLUAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLUAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLUAP1 Gene

Proteins for CLUAP1 Gene

  • Protein details for CLUAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AJ1-CLUA1_HUMAN
    Recommended name:
    Clusterin-associated protein 1
    Protein Accession:
    Q96AJ1
    Secondary Accessions:
    • O75138
    • Q65ZA3
    • Q9H8R4
    • Q9H8T1

    Protein attributes for CLUAP1 Gene

    Size:
    413 amino acids
    Molecular mass:
    48125 Da
    Quaternary structure:
    • Interacts with CLU/clusterin.
    Miscellaneous:
    • Associated with a number of cancers such as colon (PubMed:15480429) and bone cancer (PubMed:17203229). Possibly involved in polycystic kidney diseases (PubMed:15530380).
    SequenceCaution:
    • Sequence=BAA31618.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14523.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLUAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLUAP1 Gene

Proteomics data for CLUAP1 Gene at MOPED

Post-translational modifications for CLUAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CLUAP1 Gene

Domains & Families for CLUAP1 Gene

Gene Families for CLUAP1 Gene

Protein Domains for CLUAP1 Gene

Suggested Antigen Peptide Sequences for CLUAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AJ1

UniProtKB/Swiss-Prot:

CLUA1_HUMAN :
  • Belongs to the CLUAP1 family.
Family:
  • Belongs to the CLUAP1 family.
genes like me logo Genes that share domains with CLUAP1: view

Function for CLUAP1 Gene

Molecular function for CLUAP1 Gene

UniProtKB/Swiss-Prot Function:
Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity).
genes like me logo Genes that share phenotypes with CLUAP1: view

Animal Models for CLUAP1 Gene

MGI Knock Outs for CLUAP1:

Animal Model Products

miRNA for CLUAP1 Gene

miRTarBase miRNAs that target CLUAP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLUAP1 Gene

Localization for CLUAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLUAP1 Gene

Nucleus. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLUAP1 Gene COMPARTMENTS Subcellular localization image for CLUAP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CLUAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IBA --
GO:0030992 intraciliary transport particle B IBA --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with CLUAP1: view

Pathways & Interactions for CLUAP1 Gene

genes like me logo Genes that share pathways with CLUAP1: view

Pathways by source for CLUAP1 Gene

Gene Ontology (GO) - Biological Process for CLUAP1 Gene

None

No data available for SIGNOR curated interactions for CLUAP1 Gene

Drugs & Compounds for CLUAP1 Gene

No Compound Related Data Available

Transcripts for CLUAP1 Gene

Unigene Clusters for CLUAP1 Gene

Clusterin associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLUAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7:

Relevant External Links for CLUAP1 Gene

GeneLoc Exon Structure for
CLUAP1
ECgene alternative splicing isoforms for
CLUAP1

Expression for CLUAP1 Gene

mRNA expression in normal human tissues for CLUAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLUAP1 Gene

This gene is overexpressed in Testis (51.9) and Ovary (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLUAP1 Gene



SOURCE GeneReport for Unigene cluster for CLUAP1 Gene Hs.155995

mRNA Expression by UniProt/SwissProt for CLUAP1 Gene

Q96AJ1-CLUA1_HUMAN
Tissue specificity: Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines.
genes like me logo Genes that share expression patterns with CLUAP1: view

Protein tissue co-expression partners for CLUAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CLUAP1 Gene

Orthologs for CLUAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLUAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLUAP1 36
  • 100 (a)
OneToOne
CLUAP1 35
  • 99.68 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia CLUAP1 35
  • 84.67 (n)
  • 84.26 (a)
CLUAP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLUAP1 36
  • 86 (a)
OneToOne
CLUAP1 35
  • 89.16 (n)
  • 90.29 (a)
mouse
(Mus musculus)
Mammalia Cluap1 16
Cluap1 36
  • 90 (a)
OneToMany
Gm20695 36
  • 57 (a)
OneToMany
Cluap1 35
  • 86.76 (n)
  • 89.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CLUAP1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLUAP1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cluap1 35
  • 86.4 (n)
  • 90.3 (a)
chicken
(Gallus gallus)
Aves CLUAP1 35
  • 74.66 (n)
  • 74.09 (a)
CLUAP1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cluap1 35
  • 69.57 (n)
  • 71.91 (a)
zebrafish
(Danio rerio)
Actinopterygii cluap1 36
  • 64 (a)
OneToOne
cluap1 35
  • 65.21 (n)
  • 65.62 (a)
Dr.5944 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000246 35
  • 47.32 (n)
  • 39.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17599 36
  • 24 (a)
OneToOne
CG17599 35
  • 45.47 (n)
  • 32.84 (a)
worm
(Caenorhabditis elegans)
Secernentea dyf-3 35
  • 51.37 (n)
  • 43.53 (a)
dyf-3 36
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.514 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for CLUAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLUAP1 Gene

ENSEMBL:
Gene Tree for CLUAP1 (if available)
TreeFam:
Gene Tree for CLUAP1 (if available)

Paralogs for CLUAP1 Gene

No data available for Paralogs for CLUAP1 Gene

Variants for CLUAP1 Gene

Sequence variations from dbSNP and Humsavar for CLUAP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34115694 - 3,506,398(-) AATTG(A/C)CTTAA reference, missense, utr-variant-5-prime
rs9790 - 3,536,230(+) GGGTC(C/T)GGAAA reference, missense
rs1034735 -- 3,534,140(-) GAAGC(A/G)GGGGC intron-variant
rs2074523 -- 3,506,484(-) AAGTC(A/G)CCCTA intron-variant
rs1859249 -- 3,513,566(-) AGGCT(C/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLUAP1 Gene

Variant ID Type Subtype PubMed ID
nsv905213 CNV Loss 21882294
nsv905214 CNV Loss 21882294
nsv1716 CNV Insertion 18451855
nsv833128 CNV Loss 17160897

Variation tolerance for CLUAP1 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.40; 85.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLUAP1 Gene

HapMap Linkage Disequilibrium report
CLUAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLUAP1 Gene

Disorders for CLUAP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLUAP1 Gene - From: ClinVar and GeneCards

Disorder Aliases PubMed IDs
oculoectodermal syndrome
  • aplasia cutis congenita with epibulbar dermoids
leber hereditary optic neuropathy
  • leber's hereditary optic neuropathy
leber congenital amaurosis
  • lca
bone cancer
  • bone neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CLUAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLUAP1
genes like me logo Genes that share disorders with CLUAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLUAP1 Gene

Publications for CLUAP1 Gene

  1. Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. (PMID: 15480429) Takahashi M. … Furukawa Y. (Oncogene 2004) 2 3 4 67
  2. Characterization of mouse IFT complex B. (PMID: 19253336) Follit J.A. … Pazour G.J. (Cell Motil. Cytoskeleton 2009) 2 3
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CLUAP1 Gene

Sources for CLUAP1 Gene

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