CLU Gene
protein-coding GIFtS : 70 GCID: GC08 M027454
clusterin clusterin (complement lysis inhibitor, SP-40,40, sulfated... CLI, APOJ )
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Aliasesfor CLU gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Clusterin 1 Ku70-Binding Protein 12 3 CLI1 2 3 5 Testosterone-Repressed Prostate Message 22 3 APOJ1 2 3 NA1/NA22 3 KUB11 2 3 SGP22 5 TRPM-21 2 3 TRPM22 5 CLU11 2 Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2,Testosterone-Repressed Prostate Message 2, Apolipoprotein J)1 CLU21 2 APO-J2 SGP-21 2 Aging-Associated Protein 42 SP-401 2 Complement Lysis Inhibitor2 Apolipoprotein J2 3 Sulfated Glycoprotein 22 Complement Cytolysis Inhibitor2 3 Apo-J3 Complement-Associated Protein SP-40,402 3 Aging-Associated Gene 4 Protein3
External Ids: HGNC: 2095 1 Entrez Gene: 1191 2 Ensembl: ENSG00000120885 7 OMIM: 185430 5 UniProtKB: P10909 3 ORGUL members: NONCODE:n410877
Export aliases for CLU gene to outside databases Previous GC identifers: GC08M027237 GC08M027960 GC08M027477 GC08M027462 GC08M027510 GC08M025999
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Summariesfor CLU gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CLU : The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.(provided by RefSeq, May 2011) UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 Function : Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Preventsstress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation Gene Wiki entry for CLU (Clusterin)
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Genomic Viewsfor CLU gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_167187.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CLU gene promoter:PPAR-gamma1 AP-1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for CLU Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8p21-p12 Ensembl cytogenetic band: 8p21.1 HGNC cytogenetic band: 8p21-p12 CLU Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M027454: view genomic region
(about GC identifiers )
Start: 27,454,434 bp from pter End:
27,472,548 bp from pter
Size: 18,115 bases Orientation:
minus strand
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Proteinsfor CLU gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 See
protein sequence )Recommended Name: Size : 449 amino acids; 52495 DaSubunit : Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higheroligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 AND PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1
Subcellular location : Isoform 1: Secreted. Note=Can retrotranslocate from the secretory compartments to the cytosolupon cellular stress
Subcellular location : Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side.Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule (By similarity). Note=Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis
Sequence caution : Sequence=AAA35692.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAB06508.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB06508.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH10514.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH19588.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAP88927.1; Type=Erroneous gene model prediction; Sequence=AAP88927.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAT08041.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36598.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA32847.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : B2R9Q1 B3KSE6 P11380 P11381 Q2TU75 Q5HYC1 Q7Z5B9Alternative splicing : 5 isoforms : P10909-1 P10909-2 P10909-3 P10909-4 P10909-5 (Minor isoform that has been detected in a breast cancer cell line, but not in any other tissues or cell lines)Explore the universe of human proteins at neXtProt for CLU: NX_P10909 Post-translational modifications:
Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen1 Polyubiquitinated, leading to proteasomal degradation1 Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P10909 CLU Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001822.3 ENSEMBL proteins: ENSP00000315130 ENSP00000385419 ENSP00000429620 ENSP00000431096 ENSP00000428033 ENSP00000430821 ENSP00000431070 ENSP00000453247 ENSP00000429336 ENSP00000431026 ENSP00000429881 ENSP00000428779 ENSP00000427868 ENSP00000428526 ENSP00000429087 ENSP00000453939 ENSP00000446413 Reactome Protein details: P10909 Human Recombinant Protein Products: Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16 ): About this table
About GeneDecksing CLU Antibody Products: Assay Products for CLU:
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Protein
Domains /for CLU gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P10909 ProtoNet protein and cluster: P10909
1 Blocks protein family : IPB000753 UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 Similarity : Belongs to the clusterin family
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Functionfor CLU gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 Function : Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Preventsstress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation Induction : Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Up-regulated by agents thatinduce apoptosis, both at mRNA and protein level. Isoform 1 is up-regulated by androgen. Isoform 2 is down-regulated by androgen
Genatlas biochemistry entry for CLU clusterin,sulfated multifunctional glycoprotein 2,cell cycle dependent expressed in normal dermal fibroblasts,major secreted product of Sertoli cells,potentially involved in spermatogenesis,increased in hippocampus and in frontal cortex in Alzheimer's disease. Recently recognized as an autoantigen (70kDa) identified in the serum of patients with scleroderma-polymyositis syndrome,dimerizing with KUP80 to form an ATP dependent DNA unwinding enzyme (helicase II) and the regulatory component of a DNA dependent protein kinase (PRKDC),involved in DNA double-strand break repair by end joining (non homologous recombination) and V(D)J recombination Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CLU (NM_001831 ) Sino Biological Human cDNA Clone for CLU DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLU Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLU
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for CLU :Animal Models: Clu tm1Jakh for CLU7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clu) :About GeneDecksing
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Pathways & Interactionsfor CLU gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune response_Alternative complement pathway 2 Immune response_Classical complement pathway 3 Platelet activation, signaling and aggregation 4 Platelet degranulation 5 Validated targets of C-MYC transcriptional repression
Pathway sources See GeneCards unified pathways Show all pathways 3 3 1 4 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLU STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/91 Interacting proteins for CLU (P10909 1 , 2 , 3 ENSP00000315130 4 via UniProtKB, MINT, STRING , and/or I2D (see all 91 )Interactant Interaction Details GeneCard External ID(s) DISC1 Q9NRI5 1 , 3 ENSP00000355596 4 EBI-1104674,EBI-529989 I2D:
score=2 STRING: ENSP00000355596 PDIA3 P30101 2 , 3 MINT-4301334 I2D:
score=1 FOS P01100 1 , 3 ENSP00000306245 4 EBI-1104674,EBI-852851 I2D:
score=1 STRING: ENSP00000306245 PPARG P37231 1 , 3 ENSP00000287820 4 EBI-1104674,EBI-781384 I2D:
score=1 STRING: ENSP00000287820 XRCC6 P12956 3 ENSP00000352257 4 I2D:
score=3 STRING: ENSP00000352257
About this table Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30 ): About this table
About GeneDecksing
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Drugs & Compoundsfor CLU gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for CLU 10/81 Novoseek chemical compound relationships for CLU gene (see all 81 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]
58.5
25
10887098 (5), 19220628 (4), 19289586 (3), 12428799 (2)
eb 1089
49.3
2
9528999 (1), 8903423 (1)
oligonucleotide
41.7
22
19157446 (2), 16145049 (2), 7757997 (1), 18078515 (1) (see all 11 )
docetaxel
38
9
16652143 (2), 18245546 (2), 18025278 (1), 18336596 (1) (see all 5 )
kininogen
37.7
3
20143872 (1), 14559363 (1), 18484873 (1)
paclitaxel
35.4
32
16890274 (5), 18714397 (5), 16373699 (4), 10811138 (3) (see all 7 )
phosphorothioate
31.5
2
18245546 (1), 16145049 (1)
lipid
31.5
44
1746550 (4), 1431576 (3), 15457546 (2), 19357365 (2) (see all 25 )
1,25 dihydroxy vitamin d3
31
7
16886681 (2), 9528999 (1), 16179938 (1)
dutp
29.7
4
19793084 (1), 15668890 (1), 19155441 (1)
CLU / CLUS
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Transcriptsfor CLU gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CLU gene: NM_001831.3 Unigene Cluster for CLU:
Clusterin Hs.436657 [show with all ESTs ] Unigene Representative Sequence: NR_038335 18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20 ): ENST00000316403 (uc003xfw.2 uc003xfx.2 uc003xfz.2 ) ENST00000405140 ENST00000523500 ENST00000522299 ENST00000520012 ENST00000521770 ENST00000522098 ENST00000522502 ENST00000523589 ENST00000560566 ENST00000520796 ENST00000519742 ENST00000520491 ENST00000522413 ENST00000518050 ENST00000519472 ENST00000523396 ENST00000522238 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CLU (NM_001831 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLU Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLU
Additional cDNA sequence: AK313870.1 AY513288.1 BC010514.1 BC013221.1 BC019588.2 J02908.1 M25915.1 M26639.1 M64722.1 M74816.1 NR_038335.1 NR_045494.1 X14723.1
24/99 DOTS entries (see all 99 ): DT.91829646 DT.91829513
DT.97796082 DT.91983754 DT.91720241 DT.100889938 DT.87007676 DT.91941054 DT.92376991 DT.92047285 DT.97848139 DT.100889971 DT.95153361 DT.91829692 DT.100889976 DT.100889940 DT.92345718 DT.75101114 DT.100889937 DT.100806549 DT.100889925 DT.100889905 DT.100889920 DT.100889944 24/3200 AceView cDNA sequences (see all 3200 ):
BM990457 BU150743 BF091901 CR625885 BQ183954 BF935930 BU150113 BF726811 AA235650 BQ898013 CN480363 CR610801 CR591047 BQ181739 BP353065 BQ182027 CR609937 AA383407 BM819423 BF933904 BU727847 CA412693 H93557 BG060044 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CLU (see all 12 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · SP1 : - - - - - - - - SP2 : - - - - SP3 : - - - - - SP4 : - SP5 : - - - - - -
ExUns: 12c ^ 13a · 13b · 13c · 13d · 13e SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for CLU
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Expression for CLU gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CLU expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAACTAATTC
About this image CLU expression in embryonic tissues and stem cells About this table See CLU Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CLU SOURCE GeneReport for Unigene cluster: Hs.436657 UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 Tissue specificity : Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected inthe germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung SABiosciences Expression via Pathway-Focused PCR Arrays including CLU : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU
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Orthologsfor CLU gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CLU gene from 5/8 species (see all 8 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Clu5
clusterin
--
14 (34.36 cM) 65968483
chicken Aves F1NGP2_CHICK6
clusterin
46(a)
1 ↔ 1
3(107997660-108001960)
lizard Reptilia CLU6
--
40(a)
1 ↔ 1
GL343982.1(6882-21993)
African clawed frog Amphibia clu-prov2
clusterin
74.97(n)
BC046678.1
zebrafish Actinopterygii zgc733522
hypothetical protein MGC73352
75.89(n)
393775 AY352658.1
ENSEMBL Gene Tree for CLU (if available)TreeFam Gene Tree for CLU (if available)
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Paralogsfor CLU gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CLU gene CLUL1 2 1 SIMAP similar gene for CLU using alignment to 13 protein entries: CLUS_HUMAN (see all proteins ):CLUL1 About GeneDecksing
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Genomic Variantsfor CLU gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 8 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CLU (27454434 - 27472548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CLU: -- Human Gene Mutation Database (HGMD) : CLU SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor CLU gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 185430
OMIM disorders : --20/151 (see all 151 ): About MalaCards angle-closure glaucoma von hippel-lindau disease estrogen-receptor positive breast cancer lymphomatoid papulosis pelviureteric junction obstruction spinal cord injury fuchs' endothelial dystrophy anaplastic large cell lymphoma familial adenomatous polyposis tenosynovial giant cell tumor wallerian degeneration prostatitis transient neonatal neutropenia age related macular degeneration dendritic cell sarcoma inclusion body myositis follicular dendritic cell sarcoma hemolytic-uremic syndrome mycosis fungoides transthyretin amyloidosis 1 disease from the University of Copenhagen DISEASES database for CLU :Alzheimer's disease 10/95 Novoseek disease relationships for CLU gene (see all 95 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer
62.3
152
16979705 (7), 19879420 (6), 16634689 (5), 16201973 (5) (see all 54 )
senile plaques
55.5
15
1378350 (1), 15857407 (1), 10502582 (1), 7761992 (1) (see all 10 )
alzheimers disease
53.4
51
16490286 (4), 8774959 (2), 10502582 (2), 20307625 (2) (see all 27 )
carbohydrate-deficient glycoprotein syndrome
48
1
9083771 (1)
anaplastic large cell lymphoma
47.7
18
12429802 (4), 15151211 (2), 12428799 (2), 19220628 (1) (see all 5 )
drusen
47.3
7
11846519 (1), 17148042 (1), 20428236 (1), 12391305 (1) (see all 5 )
cdg ia
47.3
1
9104884 (1)
nephropathy obstructive
45.9
1
10644902 (1)
ovarian cystadenoma
45.5
1
15578711 (1)
lymphomatoid papulosis
45
4
19220628 (1), 19289586 (1)
Genetic Association Database (GAD): CLU Human Genome Epidemiology (HuGE) Navigator: CLU (39 documents) Export disorders for CLU gene to outside databases
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Publicationsfor CLU gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CLU gene, integrated from 9 sources (see all 732 ):(articles sorted by number of sources associating them with CLU) Utopia : connect your pdf to the dynamic
Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. (PubMed id 19137541) 1 , 2 , 9(2009) Clusterin expression in normal mucosa and colorectal cancer. (PubMed id 17322305) 1 , 2 , 9(2007) Apolipoprotein J: structure and tissue distribution. (PubMed id 1974459) 1 , 2 , 9(1990) The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. (PubMed id 17412999) 1 , 2 , 9(2007) Mildly acidic pH activates the extracellular molecular chaperone clusterin. (PubMed id 12176985) 1 , 2 , 9(2002) Apolipoprotein J is associated with paraoxonase in human plasma. (PubMed id 8292612) 1 , 2 , 9(1994) Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. (PubMed id 17689225) 1 , 2 , 9(2007) Identification of human plasma proteins as major clie nts for the extracellular chaperone clusterin. (PubMed id 19996109) 1 , 2 , 9(2010) Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. (PubMed id 20068069) 1 , 2 , 9(2010) Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol. (PubMed id 17451556) 1 , 2 , 9(2007)
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External Searches for CLU gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CLU gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CLU gene
(According to HUGE )
About This Section --
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Specialized Databases showing CLU gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CLU gene: CLU GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CLU gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CLU OriGene shRNA RFP for CLU OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for CLU Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CLU OriGene 3'-UTR Clone for CLU OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CLU OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CLU OriGene Custom Protein Services for CLU OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLU QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for CLU
Recombinant Protein for CLU
CLU Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU
ThermoFisher Antibody for CLU
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLU
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