Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CLU Gene

protein-coding   GIFtS: 71
GCID: GC08M027454

Clusterin

(Previous names: clusterin (complement lysis inhibitor, SP-40,40, sulfated...)
(Previous symbols: CLI, APOJ)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
clusterin1 2     TRPM-22 3
CLI1 2 3 5     SGP22 5
APOJ1 2 3     TRPM22 5
Apolipoprotein J1 2 3     Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2,
Testosterone-Repressed Prostate Message 2, Apolipoprotein J)1
Testosterone-Repressed Prostate Message 21 2 3     APO-J2
Complement Lysis Inhibitor1 2     CLU12
Sulfated Glycoprotein 21 2     CLU22
Complement Cytolysis Inhibitor2 3     SGP-22
Complement-Associated Protein SP-40,402 3     SP-402
Ku70-Binding Protein 12 3     Aging-Associated Protein 42
KUB12 3     Apo-J3
NA1/NA22 3     Aging-Associated Gene 4 Protein3

External Ids:    HGNC: 20951   Entrez Gene: 11912   Ensembl: ENSG000001208857   OMIM: 1854305   UniProtKB: P109093   

Export aliases for CLU gene to outside databases

Previous GC identifers: GC08M027237 GC08M027960 GC08M027477 GC08M027462 GC08M027510 GC08M025999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CLU Gene:
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in
the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death,
tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding
variants.(provided by RefSeq, May 2011)

GeneCards Summary for CLU Gene:
CLU (clusterin) is a protein-coding gene. Diseases associated with CLU include cystadenoma, and transient neonatal neutropenia. GO annotations related to this gene include misfolded protein binding and ubiquitin protein ligase binding. An important paralog of this gene is CLUL1.

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909
Function: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents
stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M,
CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially
unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does
not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client
complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis
and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box
protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal
degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B
transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent
release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell
proliferation

Gene Wiki entry for CLU (Clusterin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLU gene promoter:
         PPAR-gamma1   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CLU promoter sequence
   Search Chromatin IP Primers for CLU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21-p12   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21-p12

CLU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLU gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M027454:  view genomic region     (about GC identifiers)

Start:
27,454,434 bp from pter      End:
27,472,548 bp from pter
Size:
18,115 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 (See protein sequence)
Recommended Name: Clusterin precursor  
Size: 449 amino acids; 52495 Da
Subunit: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms
higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly
acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction
with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 AND PON1. Interacts with the complement complex.
Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF
(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed
cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not
interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1
Sequence caution: Sequence=AAA35692.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAB06508.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB06508.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=AAH10514.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAH19588.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAP88927.1; Type=Erroneous gene model prediction; Sequence=AAP88927.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAT08041.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG36598.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAA32847.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: B2R9Q1 B3KSE6 P11380 P11381 Q2TU75 Q5HYC1 Q7Z5B9
Alternative splicing: 5 isoforms:  P10909-1   P10909-2   P10909-3   P10909-4   P10909-5   (Minor isoform that has been detected in a breast cancer cell line, but not in any other tissues or cell lines)

Explore the universe of human proteins at neXtProt for CLU: NX_P10909

Explore proteomics data for CLU at MOPED

Post-translational modifications: 

  • Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen1
  • Polyubiquitinated, leading to proteasomal degradation1
  • Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate1
  • Glycosylation2 at Asn86, Asn103, Asn145, Ser210, Asn291, Asn354, Asn374
  • Modification sites at PhosphoSitePlus

  • See CLU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001822.3  
    ENSEMBL proteins: 
     ENSP00000315130   ENSP00000385419   ENSP00000429620   ENSP00000428033   ENSP00000430821  
     ENSP00000431070   ENSP00000453247   ENSP00000429336   ENSP00000431026   ENSP00000429881  
     ENSP00000428779   ENSP00000427868   ENSP00000428526   ENSP00000429087   ENSP00000453939  
     ENSP00000446413  
    Reactome Protein details: P10909

    CLU Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CLU (Clusterin)
    Enzo Life Sciences proteins for CLU
    OriGene Purified Proteins for CLU
    OriGene Protein Over-expression Lysate for CLU
    OriGene MassSpec for CLU
    OriGene Custom Protein Services for CLU
    GenScript Custom Purified and Recombinant Proteins Services for CLU
    Novus Biologicals CLU Proteins
    Novus Biologicals CLU Lysate
    Sino Biological Recombinant Protein for CLU
    Sino Biological Cell Lysate for CLU
    ProSpec Recombinant Protein for CLU
    Cloud-Clone Corp. Proteins for CLU

    CLU Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLU
    R&D Systems Antibodies for CLU (Clusterin)
    OriGene Antibodies for CLU
    OriGene Custom Antibody Services for CLU
    Novus Biologicals CLU Antibodies
    Abcam antibodies for CLU
    Cloud-Clone Corp. Antibodies for CLU
    ThermoFisher Antibody for CLU
    LSBio Antibodies in human, mouse, rat for CLU

    CLU Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLU
    R&D Systems ELISAs for CLU (Clusterin)         (see all)
    GenScript Custom Assay Services for CLU
    Enzo Life Sciences assays for CLU
    Cloud-Clone Corp. ELISAs for CLU
    Cloud-Clone Corp. CLIAs for CLU


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR000753 Clusterin-like
     IPR016014 Clusterin_N
     IPR016016 Clusterin
     IPR016015 Clusterin_C

    Graphical View of Domain Structure for InterPro Entry P10909

    ProtoNet protein and cluster: P10909

    1 Blocks protein domain: IPB000753 Clusterin

    UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909
    Similarity: Belongs to the clusterin family


    CLU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLUS_HUMAN, P10909
    Function: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents
    stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M,
    CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially
    unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does
    not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client
    complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis
    and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box
    protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal
    degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B
    transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent
    release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell
    proliferation
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Up-regulated by agents
    that induce apoptosis, both at mRNA and protein level. Isoform 1 is up-regulated by androgen. Isoform 2 is
    down-regulated by androgen

         Genatlas biochemistry entry for CLU:
    clusterin,sulfated multifunctional glycoprotein 2,cell cycle dependent expressed in normal dermal
    fibroblasts,major secreted product of Sertoli cells,potentially involved in spermatogenesis,increased in
    hippocampus and in frontal cortex in Alzheimer's disease. Recently recognized as an autoantigen (70kDa)
    identified in the serum of patients with scleroderma-polymyositis syndrome,dimerizing with KUP80 to form an ATP
    dependent DNA unwinding enzyme (helicase II) and the regulatory component of a DNA dependent protein kinase
    (PRKDC),involved in DNA double-strand break repair by end joining (non homologous recombination) and V(D)J
    recombination

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16113678
    GO:0016887NOT ATPase activity IDA11123922
    GO:0031625ubiquitin protein ligase binding IDA--
    GO:0051787misfolded protein binding IPI19996109
         
    CLU for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLU:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clu):
     cardiovascular system  homeostasis/metabolism  immune system  muscle  nervous system 
     other  renal/urinary system 

    CLU for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clutm1Jakh for CLU

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLU
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLU
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLU

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLU:
    hsa-mir-18a-3p (MIRT040971), hsa-mir-425-5p (MIRT039321)

    Block miRNA regulation of human, mouse, rat CLU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLU (see all 11):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-1236 hsa-miR-3138 hsa-miR-183* hsa-miR-370 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidCLU 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLU
    Predesigned siRNA for gene silencing in human, mouse, rat CLU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLU

    Clone
    Products:
         
    OriGene clones in human, mouse for CLU (see all 16)
    OriGene ORF clones in mouse, rat for CLU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLU (NM_001831)
    Sino Biological Human cDNA Clone for CLU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLU

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLU
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLU 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLUS_HUMAN, P10909: Isoform 1: Secreted. Note=Can retrotranslocate from the secretory compartments to the
    cytosol upon cellular stress
    CLUS_HUMAN, P10909: Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side.
    Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule
    (By similarity). Note=Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or
    nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular
    stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
    Detected at the mitochondrion membrane upon induction of apoptosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    extracellular5
    mitochondrion5
    nucleus5
    cytoskeleton2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA11123922
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA16113678
    GO:0005783endoplasmic reticulum IEA--

    CLU for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CLU About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Immune response Alternative complement pathway0.56
    Immune response Classic complement pathway0.56
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CLU
        Intracellular Calcium Signaling

    3 GeneGo (Thomson Reuters) Pathways for CLU
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for CLU
        Validated targets of C-MYC transcriptional repression


    1 Reactome Pathway for CLU
        Platelet degranulation



    CLU for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLU: 
              Nephrotoxicity in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cellular Stress Responses in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLU (P109091, 2, 3 ENSP000003151304) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-1104674,EBI-529989 I2D: score=2 STRING: ENSP00000355596
    PDIA3P301012, 3MINT-4301334 I2D: score=1 
    FOSP011001, 3, ENSP000003062454EBI-1104674,EBI-852851 I2D: score=1 STRING: ENSP00000306245
    PPARGP372311, 3, ENSP000002878204EBI-1104674,EBI-781384 I2D: score=1 STRING: ENSP00000287820
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IC16113678
    GO:0002576platelet degranulation TAS--
    GO:0006629lipid metabolic process NAS2387851
    GO:0006956complement activation TAS1585460
    GO:0006958complement activation, classical pathway IEA--

    CLU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLU (CLUS)

    Selected Novoseek inferred chemical compound relationships for CLU gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 58.5 25 10887098 (5), 19220628 (4), 19289586 (3), 12428799 (2)
    eb 1089 49.3 2 9528999 (1), 8903423 (1)
    oligonucleotide 41.7 22 19157446 (2), 16145049 (2), 7757997 (1), 18078515 (1) (see all 11)
    docetaxel 38 9 16652143 (2), 18245546 (2), 18025278 (1), 18336596 (1) (see all 5)
    kininogen 37.7 3 20143872 (1), 14559363 (1), 18484873 (1)
    paclitaxel 35.4 32 16890274 (5), 18714397 (5), 16373699 (4), 10811138 (3) (see all 7)
    phosphorothioate 31.5 2 18245546 (1), 16145049 (1)
    lipid 31.5 44 1746550 (4), 1431576 (3), 15457546 (2), 19357365 (2) (see all 25)
    1,25 dihydroxy vitamin d3 31 7 16886681 (2), 9528999 (1), 16179938 (1)
    dutp 29.7 4 19793084 (1), 15668890 (1), 19155441 (1)



    CLU for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CLU gene: 
    NM_001831.3  

    Unigene Cluster for CLU:

    Clusterin
    Hs.436657  [show with all ESTs]
    Unigene Representative Sequence: NR_038335
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000316403(uc003xfw.2 uc003xfx.2 uc003xfz.2) ENST00000405140
    ENST00000523500 ENST00000522299 ENST00000521770 ENST00000522098 ENST00000522502
    ENST00000523589 ENST00000560566 ENST00000520796 ENST00000519742 ENST00000520491
    ENST00000522413 ENST00000518050 ENST00000519472 ENST00000523396 ENST00000522238
    ENST00000560366

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLU (see all 11):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-1236 hsa-miR-3138 hsa-miR-183* hsa-miR-370 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidCLU 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLU
    Predesigned siRNA for gene silencing in human, mouse, rat CLU
    Clone
    Products:
         
    OriGene clones in human, mouse for CLU (see all 16)
    OriGene ORF clones in mouse, rat for CLU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLU (NM_001831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLU
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLU
    OriGene qSTAR qPCR primer pairs in human, mouse for CLU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLU
      QuantiTect SYBR Green Assays in human, mouse, rat CLU
      QuantiFast Probe-based Assays in human, mouse, rat CLU

    Additional mRNA sequence: 

    AK313870.1 AY513288.1 BC010514.1 BC013221.1 BC019588.2 J02908.1 M25915.1 M26639.1 
    M64722.1 M74816.1 NR_038335.1 NR_045494.1 X14723.1 

    Selected DOTS entries (see all 98):

    DT.91829646  DT.91829513  DT.97796082  DT.91983754  DT.91720241  DT.100889938  DT.87007676  DT.91941054 
    DT.92376991  DT.92047285  DT.97848139  DT.100889971  DT.95153361  DT.91829692  DT.100889976  DT.100889940 
    DT.92345718  DT.75101114  DT.100889937  DT.100806549  DT.100889925  DT.100889905  DT.100889920  DT.100889944 

    Selected AceView cDNA sequences (see all 3200):

    BM672941 BM311055 BF931653 BU735256 BQ182462 CA866450 BM993186 AA368187 
    BQ182165 BF931661 AA374172 CR616998 BQ182144 CR611535 BF526187 BF931334 
    CN479355 BQ637826 BQ638930 CR611421 BF965944 CR592779 AL044024 BQ718568 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLU (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ·
    SP1:              -     -     -     -     -     -                                   -                                                                 -         
    SP2:                                      -     -                                   -                                                                 -         
    SP3:                          -     -     -     -                                   -                                                                           
    SP4:                                                                                                                                                  -         
    SP5:                    -     -     -     -     -                                   -                                                                           

    ExUns: 12c ^ 13a · 13b · 13c · 13d · 13e
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for CLU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CLU expression in normal human tissues (normalized intensities)      CLU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACTAATTC
    CLU Expression
    About this image


    CLU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
    CLU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436657

    UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909
    Tissue specificity: Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected
    in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at
    protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney,
    heart, spleen and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CLU: 
              Nephrotoxicity in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cellular Stress Responses in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLU
    OriGene qSTAR qPCR primer pairs in human, mouse for CLU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLU
    QuantiTect SYBR Green Assays in human, mouse, rat CLU
    QuantiFast Probe-based Assays in human, mouse, rat CLU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CLU gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clu1 , 5 clusterin1, 5 80.92(n)1
    76.78(a)1
      14 (34.36 cM)5
    127591  NM_013492.21  NP_038520.21 
     659684835 
    chicken
    (Gallus gallus)
    Aves CLU1 clusterin 61.23(n)
    48.92(a)
      395722  NM_204900.1  NP_990231.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLU6
    clusterin
    41(a)
    1 ↔ 1
    GL343982.1(6791-26913)
    African clawed frog
    (Xenopus laevis)
    Amphibia clu-prov2 clusterin 74.97(n)    BC046678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733522 hypothetical protein MGC73352 75.89(n)   393775  AY352658.1 


    ENSEMBL Gene Tree for CLU (if available)
    TreeFam Gene Tree for CLU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CLU gene
    CLUL12  
    1 SIMAP similar gene for CLU using alignment to 12 protein entries:     CLUS_HUMAN (see all proteins):
    CLUL1

    CLU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CLU (see all 546)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285586611,2
    C--25999382(+) GGGGGC/G/TGGGGG 3 -- ds5001 int11NA 2
    rs93319481,2
    C,F--25999820(-) TCGTTCATT/-  
            
    AACAT
    6 -- nc-transcript-variantut31 cds11Minor allele frequency- -:0.07NS 164
    rs613669821,2
    C--26001468(+) TTTAGAA/-GCAGC 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs61505181,2
    C--26009890(+) tcaaa-/AAAAC 
            
    aaaac
    3 -- int10--------
    rs2017816741,2
    --26015978(+) AAAAA-/AAGAGAGA 1 -- int10--------
    rs667786071,2
    C--26015980(+) AAAAAA/GAGAGA 3 -- us2k1 int13Minor allele frequency- G:0.20WA NA CSA 5
    rs3678789011,2
    C--27458695(+) AGAGT-/GTTGGG 3 -- int10--------
    rs355007301,2
    C--27465264(+) AAAAA-/ATAGCC 3 -- int11Minor allele frequency- A:0.50NA 2
    rs114491701,2
    C--27466912(+) AAAAAA/-CCCAG 3 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs2004123361,2
    C--27466912(+) GCAAGA/GAAAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for CLU (27454434 - 27472548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLU:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831275CNV Loss17160897

    Human Gene Mutation Database (HGMD): CLU
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLU
    DNA2.0 Custom Variant and Variant Library Synthesis for CLU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 185430    OMIM disorders: --

    Selected diseases for CLU (see all 142):    About MalaCards
    cystadenoma    transient neonatal neutropenia    follicular dendritic cell tumor    nonpapillary renal cell carcinoma
    fuchs' endothelial dystrophy    ureteral obstruction    scrapie    ovarian cystadenoma
    transthyretin amyloidosis    tenosynovial giant cell tumor    follicular dendritic cell sarcoma    dendritic cell sarcoma
    wallerian degeneration    lymphomatoid papulosis    adenohypophysitis    hydronephrosis
    prion disease    myofibrillar myopathy    membranous glomerulonephritis    al amyloidosis

    1 disease from the University of Copenhagen DISEASES database for CLU:
    Alzheimer's disease

    CLU for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CLU gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 62.3 152 16979705 (7), 19879420 (6), 16634689 (5), 16201973 (5) (see all 54)
    senile plaques 55.5 15 1378350 (1), 15857407 (1), 10502582 (1), 7761992 (1) (see all 10)
    alzheimers disease 53.4 51 16490286 (4), 8774959 (2), 10502582 (2), 20307625 (2) (see all 27)
    carbohydrate-deficient glycoprotein syndrome 48 1 9083771 (1)
    anaplastic large cell lymphoma 47.7 18 12429802 (4), 15151211 (2), 12428799 (2), 19220628 (1) (see all 5)
    drusen 47.3 7 11846519 (1), 17148042 (1), 20428236 (1), 12391305 (1) (see all 5)
    cdg ia 47.3 1 9104884 (1)
    nephropathy obstructive 45.9 1 10644902 (1)
    ovarian cystadenoma 45.5 1 15578711 (1)
    lymphomatoid papulosis 45 4 19220628 (1), 19289586 (1)

    Genetic Association Database (GAD): CLU
    Human Genome Epidemiology (HuGE) Navigator: CLU (39 documents)

    Export disorders for CLU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CLU gene, integrated from 10 sources (see all 773):
    (articles sorted by number of sources associating them with CLU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. (PubMed id 19137541)1, 2, 9 Rizzi F.... Bettuzzi S. (J. Cell. Physiol. 2009)
    2. Clusterin expression in normal mucosa and colorectal cancer. (PubMed id 17322305)1, 2, 9 Andersen C.L.... Orntoft T.F. (Mol. Cell. Proteomics 2007)
    3. Apolipoprotein J: structure and tissue distribution. (PubMed id 1974459)1, 2, 9 de Silva H.V.... Robbins J. (Biochemistry 1990)
    4. The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. (PubMed id 17412999)1, 2, 9 Yerbury J.J.... Wilson M.R. (FASEB J. 2007)
    5. Mildly acidic pH activates the extracellular molecular chaperone clusterin. (PubMed id 12176985)1, 2, 9 Poon S.... Wilson M.R. (J. Biol. Chem. 2002)
    6. Apolipoprotein J is associated with paraoxonase in human plasma. (PubMed id 8292612)1, 2, 9 Kelso G.J.... Harmony J.A.K. (Biochemistry 1994)
    7. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. (PubMed id 18806885)1, 4, 9 Burdon K.P....Craig J.E. (Mol. Vis. 2008)
    8. Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. (PubMed id 17689225)1, 2, 9 Ranney M.K.... Craven R.J. (Biochim. Biophys. Acta 2007)
    9. Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. (PubMed id 19996109)1, 2, 9 Wyatt A.R. and Wilson M.R. (J. Biol. Chem. 2010)
    10. Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. (PubMed id 20410100)1, 4, 9 Voruganti V.S....Comuzzie A.G. (Am. J. Clin. Nutr. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1191 HGNC: 2095 AceView: CLU Ensembl:ENSG00000120885 euGenes: HUgn1191
    ECgene: CLU H-InvDB: CLU

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CLU Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLU Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/clu/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CLU gene:
    Search GeneIP for patents involving CLU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CLU
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for CLU (Clusterin)   Browse Cell Culture Products  
     ELISAs for CLU (Clusterin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for CLU (Clusterin)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CLU (Clusterin)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CLU (Clusterin)  
     OriGene Antibodies for CLU   OriGene RNAi products in human, mouse, rat for CLU  
     OriGene qPCR primer pairs and template standards for CLU   OriGene Protein Over-expression Lysate for CLU  
     OriGene MassSpec something-or-other for CLU   OriGene clones in human, mouse for CLU  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLU   OriGene Purified Protein for CLU  
     OriGene ORF clones in mouse, rat for CLU   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLU   OriGene Custom Protein Services for CLU  

     
     
     Block miRNA regulation of human, mouse, rat CLU using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CLU
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLU Predesigned siRNA for gene silencing in human, mouse, rat CLU
     QuantiFast Probe-based Assays in human, mouse, rat CLU QuantiTect SYBR Green Assays in human, mouse, rat CLU
     PCR Arrays including human, mouse, rat CLU Search Chromatin IP Primers for CLU
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLU  GeneGlobe Interaction Network for CLU
     Regulatory tfbs in CLU promoter
     GenScript Custom Purified and Recombinant Proteins Services for CLU GenScript cDNA clones with any tag delivered in your preferred vector for CLU
     GenScript Custom Assay Services for CLU GenScript Custom overexpressing Cell Line Services for CLU
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CLU (CLUS)
     Proteins for CLU
     Cell Lysates for CLU
     cDNA Clones for CLU
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for CLU
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CLU antibodies
     CLU proteins
     CLU lysates
     Antibodies for CLU
     See all of Abcam's Antibodies, Kits and Proteins for CLU
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CLU
     Proteins for CLU
     Antibodies for CLU
     ELISAs for CLU
     CLIAs for CLU



     Browse ESI BIO Cell Lines and PureStem Progenitors for CLU
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLU
     SwitchGear 3'UTR luciferase reporter plasmids for CLU
     SwitchGear Promoter luciferase reporter plasmids for CLU
     ThermoFisher Antibody for CLU
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLU
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLU
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLU
     LSBio Antibodies in human, mouse, rat for CLU
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLU gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4