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CLU Gene

protein-coding GIFtS: 65

GC08M027510

clusterin
(Previous names: clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CLI, APOJ)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AAG4 ^²
APOJ ^², ³
Apo-J ^³
CLI ^², ³, ⁵
KUB1 ^¹, ², ³
MGC24903 ^²
NA1/NA2 ^³
OTTHUMP00000128311 ^²
SGP-2 ^¹, ²
SGP2 ^², ⁵
SP-40 ^¹, ²
TRPM-2 ^¹, ², ³
TRPM2 ^², ⁵
clusterin ^²

Descriptions
Aging-associated gene 4 protein ^³
Apolipoprotein J ^², ³
Complement cytolysis inhibitor ^³
Complement-associated protein SP-40,40 ^³
Ku70-binding protein 1 ^³
Testosterone-repressed prostate message 2 ^², ³
aging-associated protein 4 ^²
clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) ^¹, ²
complement lysis inhibitor ^²
complement-associated protein SP-40 ^²
sulfated glycoprotein 2 ^²

External Ids
HGNC: 2095¹
Entrez Gene: 1191²
UniProtKB: P10909³
Ensembl: ENSG00000120885⁷

Search outside databases for aliases for CLU gene

Previous GC identifers: GC08M027237 GC08M027960 GC08M027477 GC08M027462

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909

Function: Not yet clear. It is known to be expressed in a variety of tissues and it seems to be

able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed

cell death (apoptosis)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CLU gene

Entrez Gene cytogenetic band: 8p21-p12 Ensembl cytogenetic band: 8p21.1 HGNC cytogenetic band: 8p21-p12

CLU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M027510: (about GC identifiers)

Start:	27,491,966 bp from pter
End:	27,528,244 bp from pter
Size:	36,279 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_023666.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909 (See protein sequence)

Recommended Name: Clusterin precursor

Size: 449 amino acids; 52495 Da

Subunit: Antiparallel disulfide-linked heterodimer. Interacts with APOA1, CLUAP1 AND PON1

Subcellular location: Secreted

Secondary accessions: B2R9Q1 P11380 P11381 Q2TU75 Q5HYC1 Q7Z5B9

REFSEQ proteins (2 alternative transcripts):

NP_001822.2 NP_976084.1

ENSEMBL proteins:

ENSP00000315130 ENSP00000369812 ENSP00000385419

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for CLU
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Apolipoprotein J )
	Human Recombinant Proteins from Abnova (CLU)

OriGene Purified Recombinant Human Protein: CLU

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	NAS	14718574
GO:0016235	aggresome	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

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Antibodies for CLU:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CLU
	Sigma-Aldrich Antibodies for CLU
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Apolipoprotein J ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CLU)
	Novus Biologicals Antibodies for CLU

Assays for CLU:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10909

ProtoNet protein and cluster: P10909

1 Blocks protein family: IPB000753 Clusterin

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909

Similarity: Belongs to the clusterin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLU)
		Millipore RNAi Products for the Analysis of CLU Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CLU)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001831

Applied Biosystems Silencer® siRNAs for CLU

Sigma-Aldrich siRNA for CLU

Sigma-Aldrich shRNA for CLU

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001831
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001831
untagged cDNA clones in CMV expression vector (see all 3): NM_001831

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001831

UniProtKB/Swiss-Prot: CLUS_HUMAN, P10909

Function: Not yet clear. It is known to be expressed in a variety of tissues and it seems to be

able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed

cell death (apoptosis)

Genatlas biochemistry entry for CLU:

clusterin,sulfated multifunctional glycoprotein 2,cell cycle dependent expressed in normal dermal

fibroblasts,major secreted product of Sertoli cells,potentially involved in

spermatogenesis,increased in hippocampus and in frontal cortex in Alzheimer's disease. Recently

recognized as an autoantigen (70kDa) identified in the serum of patients with

scleroderma-polymyositis syndrome,dimerizing with KUP80 to form an ATP dependent DNA unwinding

enzyme (helicase II) and the regulatory component of a DNA dependent protein kinase

(PRKDC),involved in DNA double-strand break repair by end joining (non homologous recombination)

and V(D)J recombination

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Clu):

	homeostasis/metabolism	immune system	muscle	nervous system
other

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17043677

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CLU

5/53 Interacting proteins for CLU (ENSP00000369812³ P10909^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 53 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	Q9NRI5¹	EBI-1104674, EBI-529989
PDIA3	P30101²	MINT-4301334
LRP2	ENSP00000263816³	STRING (score=.987)
XRCC6	ENSP00000352257³	STRING (score=.967)
POMC	ENSP00000370171³	STRING (score=.966)

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	NAS	2387851
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	IEA	--
GO:0006958	complement activation, classical pathway	IEA	--
GO:0006979	response to oxidative stress	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CLU
10/42 Novoseek chemical compound relationships for CLU gene (see all 42 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	60.40	25	10887098 (5), 19220628 (4), 19289586 (3), 12428799 (2)
oligonucleotide	40.97	22	19157446 (2), 16145049 (2), 7757997 (1), 18078515 (1) (see all 11)
phosphorothioate	33.55	2	18245546 (1), 16145049 (1)
1,25 dihydroxy vitamin d3	33.06	7	16886681 (2), 9528999 (1), 16179938 (1)
lipid	29.51	39	1746550 (4), 1431576 (3), 15457546 (2), 11281639 (2) (see all 22)
dutp	27.19	3	15668890 (1), 19155441 (1)
propidium	26.04	1	15994859 (1)
cholesterol	18.88	13	10514484 (2), 7548231 (1), 1547735 (1), 9558731 (1) (see all 10)
digitonin	10.34	3	17451556 (1), 16038898 (1)
sialic acid	9.27	15	14984241 (2), 10235309 (2), 11839462 (2), 17852805 (1)

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1 PharmGKB drug compound relationship for CLU gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
gemcitabine	FA	15126879

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLU)
		Millipore RNAi Products for the Analysis of CLU Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CLU)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001831

Sigma-Aldrich siRNA for CLU

Sigma-Aldrich shRNA for CLU

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001831 NM_203339

REFSEQ mRNAs for CLU gene (2 alternative transcripts):

NM_001831.2 NM_203339.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001831 NM_203339

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001831
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001831
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001831

Additional cDNA sequence:

AK093399.1 AK301324.1 AK313870.1 AY513288.1 BC010514.1 BC013221.1 BC019588.2 BC029972.1

CR589989.1 CR591047.1 CR591650.1 CR591665.1 CR591897.1 CR592219.1 CR592779.1 CR592811.1

CR593262.1 CR593810.1 CR594019.1 CR594036.1 CR594231.1 CR594276.1 CR594739.1 CR595225.1

CR595338.1 CR596994.1 CR597230.1 CR597462.1 CR597976.1 CR598074.1 CR598219.1 CR599454.1

CR599502.1 CR599643.1 CR599675.1 CR600109.1 CR600144.1 CR601653.1 CR602228.1 CR602800.1

CR603179.1 CR603735.1 CR604320.1 CR604582.1 CR605669.1 CR606623.1 CR606673.1 CR606818.1

CR606845.1 CR607740.1 CR607913.1 CR608066.1 CR608273.1 CR608526.1 CR609112.1 CR609937.1

CR610613.1 CR610801.1 CR611421.1 CR611535.1 CR612244.1 CR613818.1 CR615018.1 CR615768.1

CR616963.1 CR616998.1 CR617450.1 CR617497.1 CR617881.1 CR618048.1 CR619709.1 CR619820.1

CR619848.1 CR620190.1 CR620616.1 CR620651.1 CR621942.1 CR622570.1 CR623105.1 CR623634.1

CR623710.1 CR624051.1 CR624705.1 CR625885.1 J02908.1 M25915.1 M26639.1 M64722.1

M74816.1 X14723.1

24/96 DOTS entries (see all 96 ):

DT.91829646 DT.91829513 DT.97796082 DT.91983754 DT.91720241 DT.100889938 DT.87007676 DT.91941054

DT.92376991 DT.92047285 DT.97848139 DT.100889971 DT.95153361 DT.91829692 DT.100889976 DT.100889940

DT.92345718 DT.75101114 DT.100889937 DT.100806549 DT.100889925 DT.100889905 DT.100889920 DT.100889944

24/3200 AceView cDNA sequences (see all 3200 ):

BQ044937 BQ016853 T98143 BG928899 BF342924 BM696754 AA360536 CR601653

BQ180862 CD517904 H41619 BQ045029 BQ640030 BE765891 BQ639042 BU727847

BQ934007 BQ182373 BF931322 BF725140 CR598074 BU727214 BP347745 BQ183828

highest scoring ESTs for CLU:

AA336628 AI982754 AL036546 AL048826 AL531994 AL532035 AL532701 AL532803 AL532900 AL533022

Unigene Cluster for CLU:

Clusterin

Hs.436657 [show with all ESTs]

Unigene Representative Sequence: NM_203339

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CLU (see all 12 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	·
SP1:					-		-		-		-		-		-												-																						-
SP2:													-		-												-																						-
SP3:									-		-		-		-												-
SP4:																																																	-
SP5:							-		-		-		-		-												-

ExUns:	12c	^	13a	·	13b	·	13c	·	13d	·	13e
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CLU

3 Ensembl transcripts including schematic representations:

ENST00000316403 ENST00000380446 ENST00000405140

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CLU expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CLU

¹ / ² / ³

12 probe-sets matching CLU gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75382_i_at²^{, 3}	U95-D	1	1.00	1.00	0.87	0.86	AI382415	0.60	1.00	0.82	1
43817_f_at²^{, 3}	U95-B	1	1.00	1.00	0.91	1.16	AW008412	0.80	1.00	0.91	1
36780_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.09	M25915	0.80	1.00	0.91	1
80587_s_at²^{, 3}	U95-E	1	1.00	1.00	0.96	0.87	AI969364	0.60	1.00	0.82	1
63969_f_at²^{, 3}	U95-C	1	1.00	1.00	0.97	1.18	AI982754	0.80	1.00	0.91	1
75384_f_at²^{, 3}	U95-D	1	0.75	1.00	0.88	0.85	AI382415	0.60	1.00	0.82	1
208792_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M25915	0.80	1.00	0.91	1
222043_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI982754	0.80	1.00	0.91	1
208791_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M25915	0.80	1.00	0.91	1
208792_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222043_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208791_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CLU for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAACTAATTC

SOURCE GeneReport for Unigene cluster: Hs.436657
Expression variation in blood from EXPOLDB for CLU

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CLU gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CLU¹	--	clusterin	82.85(n) 78.88(a)	442971 NM_001003370.1 NP_001003370.1
chimpanzee (Pan troglodytes)	CLU¹	--	clusterin	99(n) 98.4(a)	464075 XM_519677.2 XP_519677.2
cow (Bos taurus)	CLU¹	--	clusterin	79.57(n) 71.75(a)	280750 NM_173902.2 NP_776327.1
rat (Rattus norvegicus)	Clu¹	--	clusterin	81.8(n) 77.4(a)	24854 XM_001053032.1 XP_001053032.1
mouse (Mus musculus)	Clu^{1, 5}	14 (28.00 cM)⁵	clusterin^{1, 5}	80.8(n)¹ 75.89(a)¹	12759¹ NM_013492.1¹ NP_038520.1¹ AF182509⁵ AF248057⁵ (see all 19)

About this table Species with no ortholog for CLU

ENSEMBL Gene Tree for CLU

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CLU gene

CLUL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in CLU are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9331888^1,2	A,C,F,H	27524779(-)	`CCAAAG/CGGACT`	2	--	ut5¹ int¹		5	NS EU EA WA	592
	rs9314349^1,2	A,C,F,H	27530121(+)	`TAGACA/GTTGAT`	1	--	ng3¹		12	EU EA WA	1256
	rs3087554^1,2	A,C,F,H	27511359(-)	`GGGGCA/GGGCAG`	2	--	ut3¹		12	NS MN EU EA WA	1210
	rs9331942^1,2	C,F,H	27511031(-)	`CATAAT/CTGATG`	2	--	ut3¹		5	NS EU EA WA	578
	rs9331946^1,2	C,F,H	27510862(-)	`TCCACC/TGCCGG`	2	--	ut3¹ ese³		11	NS EU EA WA	1060
	rs10441615^1,2	C,F,H	27528666(+)	`GACCCG/ACCAGG`	1	--	ng3¹		4	EU EA WA	382
	rs9331949^1,2	C,F,H	27510603(-)	`AATTTA/GTAGCT`	2	--	ut3¹ ese³		11	NS EU EA WA	1032
	rs546076^1,2	A,F,H	27526128(+)	`AGAACC/TGTGAC`	2	--	int¹ ng3¹		5	NA EA EU WA	492
	rs9331883^1,2	C,F,H	27525888(-)	`CCCAGC/GCTCAG`	2	--	int¹ ng3¹		11	NS EU EA WA	1016
	rs10503814^1,2	C,F,H	27510492(+)	`AATTTC/TCTTGA`	2	--	ut3¹		16	NS EU EA WA NA	1086

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HapMap Linkage Disequilibrium images for CLU (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 185430

10/95 Novoseek disease relationships for CLU gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	61.99	131	16979705 (7), 16634689 (5), 12783666 (5), 16201973 (5) (see all 49)
senile plaques	55.42	14	1378350 (1), 15857407 (1), 10502582 (1), 7761992 (1) (see all 9)
alzheimers disease	52.28	46	16490286 (4), 8774959 (2), 10502582 (2), 9560017 (2) (see all 24)
anaplastic large cell lymphoma	49.98	18	12429802 (4), 15151211 (2), 12428799 (2), 19220628 (1) (see all 5)
carbohydrate-deficient glycoprotein syndrome	49.37	1	9083771 (1)
cdg ia	49.04	1	9104884 (1)
nephropathy obstructive	48.52	1	10644902 (1)
ovarian cystadenoma	47.50	1	15578711 (1)
lymphomatoid papulosis	47.30	4	19220628 (1), 19289586 (1)
drusen	45.85	6	11846519 (1), 17148042 (1), 12391305 (1), 15180251 (1)

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Human Gene Mutation Database: CLU
Genetic Association Database: CLU
Human Genome Epidemiology Navigator: CLU (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/527 PubMed articles for CLU gene (see all 527 ):

Apolipoprotein J: structure and tissue distribution. (PubMed id 1974459)^{1, 3, 4} de Silva H.V.... Robbins J. (1990)
Apolipoprotein J is associated with paraoxonase in human plasma. (PubMed id 8292612)^{1, 3, 4} Kelso G.J....Harmony J.A. (1994)
Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females. (PubMed id 15883054)^{1, 3, 6} Miwa Y....Kawano Y. (2005)
Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. (PubMed id 8181474)^{1, 3, 4} Wong P....Tenniswood M. (1994)
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. (PubMed id 8328966)^{1, 3, 4} Ghiso J.... Frangione B. (1993)
Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death. (PubMed id 1924317)^{1, 3, 4} Danik M.... Suh M. (1991)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)^{3, 4} Nusbaum C....Lander E.S. (2006)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{3, 4} Ramachandran P....Loo J.A. (2006)
Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. (PubMed id 15925890)^{3, 6} Chen M....Shan K. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1191	HGNC: 2095	AceView: CLU	Ensembl:ENSG00000120885	euGenes: HUgn1191
ECgene: CLU	H-InvDB: CLU

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CLU	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/clu/

Licensable Technologies for CLU
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CLU:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CLU-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CLU		Antibodies for CLU
	Explore super-pooled esiRNAs		Proteins for CLU
	Lentivirus-delivered shRNAs for CLU		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (CLU)
	Antibodies (CLU)
	Chimera RNAi (CLU)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Apolipoprotein J )
	Antibodies (Apolipoprotein J )

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CLU

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CLU

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CLU Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CLU Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CLU

Summaries
for CLU

Genomic Location
for CLU

Proteins
for CLU

Protein Domains/
Families
for CLU

Gene Function
for CLU

Pathways & Interactions
for CLU

Drugs & Compounds
for CLU

Transcripts
for CLU

Expression
for CLU

Orthologs
for CLU

Paralogs
for CLU

SNPs/Variants
for CLU

Disorders & Mutations
for CLU

Medical News
for CLU

Publications
for CLU

Search for CLU

Genome Databases showing CLU

Other Databases showing CLU

Specialized Databases showing CLU

Licensable Technologies
for CLU

Services
for CLU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CLU (Gene Symbol)
AAG4
APOJ
Apo-J
CLI
KUB1
MGC24903
NA1/NA2
OTTHUMP00000128311
SGP-2
SGP2
SP-40
TRPM-2
TRPM2
clusterin
Aging-associated gene 4 protein
Apolipoprotein J
Complement cytolysis inhibitor
Complement-associated protein SP-40,40
Ku70-binding protein 1
Testosterone-repressed prostate message 2
aging-associated protein 4
clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
complement lysis inhibitor
complement-associated protein SP-40
sulfated glycoprotein 2

CLU Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CLU

Summariesfor CLU

Genomic Locationfor CLU

Proteinsfor CLU

Protein Domains/Familiesfor CLU

Gene Functionfor CLU

Pathways & Interactionsfor CLU

Drugs & Compoundsfor CLU

Transcriptsfor CLU

Expression for CLU

Orthologsfor CLU

Paralogsfor CLU

SNPs/Variantsfor CLU

Disorders & Mutationsfor CLU

Medical Newsfor CLU

Publicationsfor CLU

Search for CLU

Genome Databases showing CLU

Other Databases showing CLU

Specialized Databases showing CLU

Licensable Technologiesfor CLU

Servicesfor CLU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CLU

Summaries
for CLU

Genomic Location
for CLU

Proteins
for CLU

Protein Domains/
Families
for CLU

Gene Function
for CLU

Pathways & Interactions
for CLU

Drugs & Compounds
for CLU

Transcripts
for CLU

Expression
for CLU

Orthologs
for CLU

Paralogs
for CLU

SNPs/Variants
for CLU

Disorders & Mutations
for CLU

Medical News
for CLU

Publications
for CLU

Licensable Technologies
for CLU

Services
for CLU