Aliases for CLTRN Gene
External Ids for CLTRN Gene
Previous HGNC Symbols for CLTRN Gene
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
GeneCards Summary for CLTRN Gene
CLTRN (Collectrin, Amino Acid Transport Regulator) is a Protein Coding gene. Diseases associated with CLTRN include Aminoaciduria and Polycystic Kidney Disease 4 With Or Without Hepatic Disease. Among its related pathways are Peptide hormone metabolism and Metabolism of proteins. An important paralog of this gene is ACE2.
UniProtKB/Swiss-Prot for CLTRN Gene
Regulator of SNARE complex function. Stimulator of beta cell replication.