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CLTC Gene

protein-coding GIFtS: 68

GC17P055052

clathrin, heavy chain (Hc)
(Previous names: clathrin, heavy polypeptide (Hc), clathrin, heavy chain, clathrin, heavy polypeptide-like 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CLTCL2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHC ^²
CHC17 ^²
CLH-17 ^², ³
CLH17 ^³
CLTCL2 ^², ³
Hc ^¹, ²
KIAA0034 ^², ³

Descriptions
clathrin heavy chain 1 ^²
clathrin, heavy chain ^¹
clathrin, heavy chain (Hc) ^²
clathrin, heavy polypeptide (Hc) ^¹, ²
clathrin, heavy polypeptide-like 2 ^¹, ²

External Ids
HGNC: 2092¹
Entrez Gene: 1213²
UniProtKB: Q00610³
Ensembl: ENSG00000141367⁷

Search outside databases for aliases for CLTC gene

Previous GC identifers: GC17P057433 GC17P060146 GC17P058039 GC17P058171

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CLTC:

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called

coated vesicles and coated pits. These specialized organelles are involved in the intracellular

trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the

clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq]

UniProtKB/Swiss-Prot: CLH1_HUMAN, Q00610

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two

different adapter protein complexes link the clathrin lattice either to the plasma membrane or to

the trans-Golgi network

Gene Wiki entry for CLTC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CLTC gene

Entrez Gene cytogenetic band: 17q11-qter Ensembl cytogenetic band: 17q23.1 HGNC cytogenetic band: 17q11-qter

CLTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P055052: (about GC identifiers)

Start:	55,051,832 bp from pter
End:	55,129,099 bp from pter
Size:	77,268 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CLH1_HUMAN, Q00610 (See protein sequence)

Recommended Name: Clathrin heavy chain 1

Size: 1675 amino acids; 191615 Da

Subunit: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic

subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both

the pH and the concentration of calcium. Interacts with HIP1

Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note=Cytoplasmic

face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from

stage I to stage IV

Secondary accessions: Q6N0A0 Q86TF2

Alternative splicing: 2 isoforms: Q00610-1 Q00610-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004850.1

ENSEMBL proteins:

ENSP00000269122 ENSP00000376763

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Clathrin heavy chain)
	Human Recombinant Proteins from Abnova (CLTC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	EXP	10567358 11157096
GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA	--
GO:0030132	clathrin coat of coated pit	IEA	--
GO:0030659	cytoplasmic vesicle membrane	IEA	--
GO:0031410	cytoplasmic vesicle	IEA	--

About this table

Antibodies for CLTC:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CLTC
	Sigma-Aldrich Antibody Arrays and Antibodies for CLTC
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CLTC (Clathrin Heavy Chain)
	Antibodies from Abcam (Clathrin heavy chain), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CLTC

Assays for CLTC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q00610

ProtoNet protein and cluster: Q00610

1 Blocks protein family: IPB000547 7-Fold repeat in clathrin and VPS proteins

UniProtKB/Swiss-Prot: CLH1_HUMAN, Q00610

Similarity: Belongs to the clathrin heavy chain family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLTC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLTC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC051800

Applied Biosystems Silencer® siRNAs for CLTC

Sigma-Aldrich siRNA for CLTC

Sigma-Aldrich shRNA for CLTC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004859
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004859
untagged cDNA clones in CMV expression vector (see all 2): BC051800

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004859

UniProtKB/Swiss-Prot: CLH1_HUMAN, Q00610

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two

different adapter protein complexes link the clathrin lattice either to the plasma membrane or to

the trans-Golgi network

Genatlas biochemistry entry for CLTC:

clathrin,heavy chain 1,ubiquitously expressed,component of coated vesicles and coated

pits,translocated to plasma membrane through AP2 binding,also expressed in synaptic vesicles

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	1765375
GO:0005515	protein binding	IPI	11799118 17220478 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for CLTC (Your Favorite Gene powered by Ingenuity)

Virus Entry via Endocytic Pathways
Huntington's Disease Signaling
CTLA4 Signaling in Cytotoxic T Lymphocytes
Clathrin-mediated Endocytosis

GeneDecks CLTC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CLTC

5/167 Interacting proteins for CLTC (ENSP00000269122³ Q00610^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 167 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLTA	P09496²	STRING (score=.997) MINT-6802072
HIP1	O00291²	STRING (score=.998) MINT-3979944
TNK2	Q07912²	STRING (score=.987) MINT-62881
IKBKE	Q14164¹^,²	EBI-354967, EBI-307369 MINT-48107 EBI-354967, EBI-307369 MINT-48107
MCC	P23508¹	EBI-354967, EBI-307531

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	NAS	1765375
GO:0016192	vesicle-mediated transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CLTC

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CLTC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CLTC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC051800

Sigma-Aldrich siRNA for CLTC

Sigma-Aldrich shRNA for CLTC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004859

REFSEQ mRNAs for CLTC gene:

NM_004859.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004859

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004859
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004859
                                 untagged cDNA clones in CMV expression vector (see all 2): BC051800

Additional cDNA sequence:

AB073891.1 AF130062.1 AK127134.1 BC015854.1 BC036430.1 BC051800.2 BC054489.1 BX640615.1

CR616097.1 CR617482.1 CR625541.1 D21260.1 X55878.1

24/46 DOTS entries (see all 46 ):

DT.219977 DT.91887587 DT.95338490 DT.120930523 DT.95155315 DT.95367945 DT.92471783 DT.100728189

DT.100882689 DT.100672405 DT.120930474 DT.120930620 DT.100882683 DT.95367962 DT.97864554 DT.100882690

DT.40281160 DT.403696 DT.92471757 DT.95367929 DT.120930529 DT.120930740 DT.304623 DT.95367944

24/991 AceView cDNA sequences (see all 991 ):

AA877897 CD654636 AI371863 BP377054 BQ640056 BU740091 AA723567 BF983747

BQ213665 BQ220425 BP382928 BG105441 BG680812 CA419015 CA429666 CR625541

D45298 CA866004 AL555734 BU507459 BP362844 BM804243 AA361745 AL699458

highest scoring ESTs for CLTC:

D21260 AA351469 AA374706 AA620496 AA829032 AI355350 AI983431 AK127134 AU159938 AV681786

Unigene Cluster for CLTC:

Clathrin, heavy chain (Hc)

Hs.491351 [show with all ESTs]

Unigene Representative Sequence: NM_004859

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CLTC (see all 11 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^
SP1:					-												-										-										-				-
SP2:																	-										-										-				-
SP3:					-												-										-										-				-
SP4:
SP5:

ExUns:	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	^	34a	·	34b	·	34c	^	35a	·	35b	·	35c
SP1:																															-		-		-				-
SP2:																															-		-		-				-
SP3:																															-		-		-
SP4:
SP5:																																	-		-				-

About this scheme

ECgene alternative splicing isoforms for CLTC

2 Ensembl transcripts including schematic representations:

ENST00000269122 ENST00000393043

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CLTC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CLTC

¹ / ² / ³

5 probe-sets matching CLTC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91168_at²^{, 3}	U95-E	1	1.00	1.00	0.91	1.34	AI983431	0.80	1.00	0.91	1
41159_at²^{, 3}	U95-A	1	1.00	1.00	0.49	1.12	D21260	1.00	1.00	1.00	1
84461_at²^{, 3}	U95-E	1	0.81	1.00	0.67	0.56	AA831561	0.60	1.00	0.82	1
200614_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004859	0.60	1.00	0.82	1
200614_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CLTC for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATATTGTGCC

SOURCE GeneReport for Unigene cluster: Hs.491351
Expression variation in blood from EXPOLDB for CLTC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CLTC gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CLTC¹	--	clathrin, heavy chain (Hc)	95.22(n) 99.82(a)	480578 XM_862134.1 XP_867227.1
chimpanzee (Pan troglodytes)	CLTC¹	--	clathrin, heavy chain (Hc)	99.8(n) 100(a)	455168 XM_001135882.1 XP_001135882.1
cow (Bos taurus)	CLTC¹	--	clathrin, heavy chain (Hc)	94.05(n) 99.94(a)	281080 NM_174023.2 NP_776448.1
rat (Rattus norvegicus)	Cltc¹	--	clathrin, heavy chain (Hc)	91.24(n) 99.76(a)	54241 NM_019299.1 NP_062172.1
mouse (Mus musculus)	Cltc^{1, 5}	11⁵	clathrin, heavy polypeptide (Hc)^{1, 5}	92.04(n)¹ 99.88(a)¹	67300¹ NM_001003908.1¹ NP_001003908.1¹ AI840975⁵ AK014236⁵ (see all 21)

About this table Species with no ortholog for CLTC

ENSEMBL Gene Tree for CLTC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CLTC gene

CLTCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/352 NCBI SNPs in CLTC are shown (see all 352 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 122)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1881442^1,2	A,C,F,H	55051033(-)	`AAACCT/CGAAGG`	1	--	ng5¹		3		EU EA	282
	rs3803863^1,2	A,C,F,H	55051555(-)	`CCCCTT/CACAGG`	1	--	ng5¹		5		EA EU WA	1902
	rs4374230^1,2	A,C,F,H	55050551(+)	`CAAAAT/CTATCG`	1	--	ng5¹		10		EU EA NA WA	840
	rs3803861^1,2	C,F,H	55051755(-)	`CGTGGG/ACGCTT`	1	--	ng5¹		7		EA MN EU WA	3162
	rs12944716^1,2	A,F,H	55050774(+)	`ACCAGG/AAAGGT`	1	--	ng5¹ tfbs³		3		EU EA	288
--	rs10853014^1,2	A,C	55127596(+)	`gagttC/Tgagac`	1	--	ut3¹		0	--	--	--	--
	rs8066311^1,2	F,H	55050832(+)	`AGACAG/CGATGC`	1	--	ng5¹		4		EU EA WA	418
	rs3803862^1,2	C,F	55051609(-)	`AGGCAC/TGACGG`	1	--	ng5¹		2		MN EA	1252
	rs1064562^1,2	H	55092676(+)	`TGCTCT/ATTTTG`	1	H/L	mis¹		5		MN EU EA WA	590
	rs2292341^1,2	H	55116030(-)	`CAGTGG/ATAGCT`	1	S/P	mis¹ ese³		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for CLTC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118955

1 PharmGKB disease relationship for CLTC gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/80 PubMed articles for CLTC gene (see all 80 ):

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{2, 3, 4} Nomura N....Tabata S. (1994)
Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. (PubMed id 1765375)^{2, 3, 4} Dodge G.R.... Iozzo R.V. (1991)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. (PubMed id 11532990)^{3, 4} Waelter S....Wanker E.E. (2001)
Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP. (PubMed id 18042253)³ Chong D.C....Paton A.W. (2008)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1213	HGNC: 2092	AceView: CLTC	Ensembl:ENSG00000141367	euGenes: HUgn1213
ECgene: CLTC	H-InvDB: CLTC

(According to HUGE)
About This Section

HUGE: KIAA0034

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CLTC	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Clathrin

Licensable Technologies for CLTC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CLTC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CLTC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CLTC		Antibodies for CLTC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CLTC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CLTC)
	Search for Antibodies
	Chimera RNAi (CLTC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CLTC (Clathrin Heavy Chain)

	Recombinant Proteins (Clathrin heavy chain)
	Antibodies (Clathrin heavy chain)

Search OriGene for CLTC

Search Tocris compounds for CLTC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CLTC

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CLTC Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CLTC

Summaries
for CLTC

Genomic Location
for CLTC

Proteins
for CLTC

Protein Domains/
Families
for CLTC

Gene Function
for CLTC

Pathways & Interactions
for CLTC

Drugs & Compounds
for CLTC

Transcripts
for CLTC

Expression
for CLTC

Orthologs
for CLTC

Paralogs
for CLTC

SNPs/Variants
for CLTC

Disorders & Mutations
for CLTC

Medical News
for CLTC

Publications
for CLTC

Search for CLTC

Genome Databases showing CLTC

Other Databases showing CLTC

Specialized Databases showing CLTC

Licensable Technologies
for CLTC

Services
for CLTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CLTC Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CLTC

Summariesfor CLTC

Genomic Locationfor CLTC

Proteinsfor CLTC

Protein Domains/Familiesfor CLTC

Gene Functionfor CLTC

Pathways & Interactionsfor CLTC

Drugs & Compoundsfor CLTC

Transcriptsfor CLTC

Expression for CLTC

Orthologsfor CLTC

Paralogsfor CLTC

SNPs/Variantsfor CLTC

Disorders & Mutationsfor CLTC

Medical Newsfor CLTC

Publicationsfor CLTC

Search for CLTC

Genome Databases showing CLTC

Other Databases showing CLTC

Specialized Databases showing CLTC

Licensable Technologiesfor CLTC

Servicesfor CLTC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CLTC

Summaries
for CLTC

Genomic Location
for CLTC

Proteins
for CLTC

Protein Domains/
Families
for CLTC

Gene Function
for CLTC

Pathways & Interactions
for CLTC

Drugs & Compounds
for CLTC

Transcripts
for CLTC

Expression
for CLTC

Orthologs
for CLTC

Paralogs
for CLTC

SNPs/Variants
for CLTC

Disorders & Mutations
for CLTC

Medical News
for CLTC

Publications
for CLTC

Licensable Technologies
for CLTC

Services
for CLTC