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Aliases for CLTB Gene

Aliases for CLTB Gene

  • Clathrin Light Chain B 2 3
  • Clathrin, Light Chain B 2 3 5
  • Clathrin, Light Polypeptide (Lcb) 2 3
  • LCB 3 4
  • Clathrin, Light Chain (Lcb) 3

External Ids for CLTB Gene

Previous GeneCards Identifiers for CLTB Gene

  • GC05M176168
  • GC05M176638
  • GC05M175754
  • GC05M175800
  • GC05M175752
  • GC05M175819
  • GC05M170744

Summaries for CLTB Gene

Entrez Gene Summary for CLTB Gene

  • Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLTB Gene

CLTB (Clathrin Light Chain B) is a Protein Coding gene. Diseases associated with CLTB include Leber Congenital Amaurosis. Among its related pathways are CTLA4 Signaling and Bacterial invasion of epithelial cells. GO annotations related to this gene include structural molecule activity and peptide binding. An important paralog of this gene is CLTA.

UniProtKB/Swiss-Prot for CLTB Gene

  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLTB Gene

Genomics for CLTB Gene

Regulatory Elements for CLTB Gene

Enhancers for CLTB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLTB on UCSC Golden Path with GeneCards custom track

Promoters for CLTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLTB on UCSC Golden Path with GeneCards custom track

Genomic Location for CLTB Gene

Chromosome:
5
Start:
176,392,455 bp from pter
End:
176,416,569 bp from pter
Size:
24,115 bases
Orientation:
Minus strand

Genomic View for CLTB Gene

Genes around CLTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLTB Gene

Proteins for CLTB Gene

  • Protein details for CLTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09497-CLCB_HUMAN
    Recommended name:
    Clathrin light chain B
    Protein Accession:
    P09497
    Secondary Accessions:
    • Q53Y37
    • Q6FHW1

    Protein attributes for CLTB Gene

    Size:
    229 amino acids
    Molecular mass:
    25190 Da
    Quaternary structure:
    • Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.

    Alternative splice isoforms for CLTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLTB Gene

Proteomics data for CLTB Gene at MOPED

Post-translational modifications for CLTB Gene

  • Ubiquitination at Lys 223
  • Modification sites at PhosphoSitePlus

Other Protein References for CLTB Gene

No data available for DME Specific Peptides for CLTB Gene

Domains & Families for CLTB Gene

Protein Domains for CLTB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLTB Gene

Graphical View of Domain Structure for InterPro Entry

P09497

UniProtKB/Swiss-Prot:

CLCB_HUMAN :
  • Belongs to the clathrin light chain family.
Family:
  • Belongs to the clathrin light chain family.
genes like me logo Genes that share domains with CLTB: view

No data available for Gene Families for CLTB Gene

Function for CLTB Gene

Molecular function for CLTB Gene

GENATLAS Biochemistry:
clathrin,light chain B (Lcb),component of coated vesicles and coated pits,translocated to plasma membrane through AP2 binding,also expressed in synaptic vesicles
UniProtKB/Swiss-Prot Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
genes like me logo Genes that share phenotypes with CLTB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLTB Gene

Localization for CLTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLTB Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLTB Gene COMPARTMENTS Subcellular localization image for CLTB gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CLTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane IDA --
GO:0030130 clathrin coat of trans-Golgi network vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CLTB: view

Pathways & Interactions for CLTB Gene

genes like me logo Genes that share pathways with CLTB: view

SIGNOR curated interactions for CLTB Gene

Other effect:

Gene Ontology (GO) - Biological Process for CLTB Gene

None

Drugs & Compounds for CLTB Gene

No Compound Related Data Available

Transcripts for CLTB Gene

Unigene Clusters for CLTB Gene

Clathrin, light chain B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLTB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5:
SP6: - - - - - - -

Relevant External Links for CLTB Gene

GeneLoc Exon Structure for
CLTB
ECgene alternative splicing isoforms for
CLTB

Expression for CLTB Gene

mRNA expression in normal human tissues for CLTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLTB Gene

This gene is overexpressed in Brain (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLTB Gene



SOURCE GeneReport for Unigene cluster for CLTB Gene Hs.484241

genes like me logo Genes that share expression patterns with CLTB: view

Protein tissue co-expression partners for CLTB Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLTB Gene

Orthologs for CLTB Gene

This gene was present in the common ancestor of animals.

Orthologs for CLTB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLTB 35
  • 92.06 (n)
  • 96.67 (a)
CLTB 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLTB 35
  • 93.52 (n)
  • 98.1 (a)
CLTB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cltb 35
  • 89.73 (n)
  • 95.26 (a)
Cltb 16
Cltb 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLTB 35
  • 91.25 (n)
  • 88.12 (a)
rat
(Rattus norvegicus)
Mammalia Cltb 35
  • 90.84 (n)
  • 95.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CLTB 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLTB 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLTB 35
  • 79.39 (n)
  • 80.19 (a)
CLTB 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLTB 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cltb 35
  • 69.77 (n)
  • 74.02 (a)
Str.3405 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68704 35
zebrafish
(Danio rerio)
Actinopterygii LOC100329879 35
  • 68.91 (n)
  • 64.9 (a)
FP102272.1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.226 35
fruit fly
(Drosophila melanogaster)
Insecta Clc 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
CSA.79 36
  • 40 (a)
ManyToMany
Species with no ortholog for CLTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLTB Gene

ENSEMBL:
Gene Tree for CLTB (if available)
TreeFam:
Gene Tree for CLTB (if available)

Paralogs for CLTB Gene

Paralogs for CLTB Gene

(1) SIMAP similar genes for CLTB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLTB: view

Variants for CLTB Gene

Sequence variations from dbSNP and Humsavar for CLTB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34180215 -- 176,418,009(-) AATCA(-/G)AAAAA upstream-variant-2KB
rs72807229 -- 176,416,931(+) TCTGT(A/G)AGAAG upstream-variant-2KB
rs34379169 -- 176,417,221(-) TTGGC(-/A)AAAGC upstream-variant-2KB
rs7442946 -- 176,416,889(+) CTAGG(C/T)TGGGA upstream-variant-2KB
rs111288271 -- 176,416,134(+) CCCCG(A/C/G)GTGCG intron-variant

Variation tolerance for CLTB Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CLTB Gene

Disorders for CLTB Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLTB Gene - From: DISEASES

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search CLTB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLTB

Genetic Association Database (GAD)
CLTB
Human Genome Epidemiology (HuGE) Navigator
CLTB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLTB
genes like me logo Genes that share disorders with CLTB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLTB Gene

Publications for CLTB Gene

  1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PMID: 7713494) Ponnambalam S. … Parham P. (Genomics 1994) 2 3 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. (PMID: 24852344) Majeed S.R. … Brodsky F.M. (Nat Commun 2014) 3
  5. Autophagic degradation of the inhibitory p53 isoform I9133p53I+ as a regulatory mechanism for p53-mediated senescence. (PMID: 25144556) Horikawa I. … Harris C.C. (Nat Commun 2014) 3

Products for CLTB Gene

Sources for CLTB Gene

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