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Aliases for CLTB Gene

Aliases for CLTB Gene

  • Clathrin, Light Chain B 2 3
  • Clathrin, Light Polypeptide (Lcb) 2 3
  • LCB 3 4
  • Clathrin, Light Chain (Lcb) 3
  • Clathrin Light Chain B 3

External Ids for CLTB Gene

Previous GeneCards Identifiers for CLTB Gene

  • GC05M176168
  • GC05M176638
  • GC05M175754
  • GC05M175800
  • GC05M175752
  • GC05M175819
  • GC05M170744

Summaries for CLTB Gene

Entrez Gene Summary for CLTB Gene

  • Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLTB Gene

CLTB (Clathrin, Light Chain B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Endocytosis. GO annotations related to this gene include structural molecule activity and peptide binding. An important paralog of this gene is CLTA.

UniProtKB/Swiss-Prot for CLTB Gene

  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLTB Gene

Genomics for CLTB Gene

Regulatory Elements for CLTB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLTB Gene

176,392,455 bp from pter
176,416,569 bp from pter
24,115 bases
Minus strand

Genomic View for CLTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLTB Gene

Proteins for CLTB Gene

  • Protein details for CLTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Clathrin light chain B
    Protein Accession:
    Secondary Accessions:
    • Q53Y37
    • Q6FHW1

    Protein attributes for CLTB Gene

    229 amino acids
    Molecular mass:
    25190 Da
    Quaternary structure:
    • Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.

    Alternative splice isoforms for CLTB Gene


neXtProt entry for CLTB Gene

Proteomics data for CLTB Gene at MOPED

Post-translational modifications for CLTB Gene

  • Ubiquitination at Lys204 and Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for CLTB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLTB Gene

Domains for CLTB Gene

Protein Domains for CLTB Gene


Suggested Antigen Peptide Sequences for CLTB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the clathrin light chain family.
  • Belongs to the clathrin light chain family.
genes like me logo Genes that share domains with CLTB: view

No data available for Gene Families for CLTB Gene

Function for CLTB Gene

Molecular function for CLTB Gene

GENATLAS Biochemistry:
clathrin,light chain B (Lcb),component of coated vesicles and coated pits,translocated to plasma membrane through AP2 binding,also expressed in synaptic vesicles
UniProtKB/Swiss-Prot Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Gene Ontology (GO) - Molecular Function for CLTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding --
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 11889126
GO:0032050 clathrin heavy chain binding IBA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with CLTB: view

Phenotypes for CLTB Gene

genes like me logo Genes that share phenotypes with CLTB: view

miRNA for CLTB Gene

miRTarBase miRNAs that target CLTB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CLTB Gene

Localization for CLTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLTB Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.

Subcellular locations from

Jensen Localization Image for CLTB Gene COMPARTMENTS Subcellular localization image for CLTB gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CLTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane IDA --
GO:0030118 clathrin coat NAS 3267234
GO:0030125 clathrin vesicle coat IBA --
genes like me logo Genes that share ontologies with CLTB: view

Pathways for CLTB Gene

genes like me logo Genes that share pathways with CLTB: view

Gene Ontology (GO) - Biological Process for CLTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0016192 vesicle-mediated transport --
GO:0072583 clathrin-mediated endocytosis IBA --
genes like me logo Genes that share ontologies with CLTB: view

Transcripts for CLTB Gene

Unigene Clusters for CLTB Gene

Clathrin, light chain B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLTB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP6: - - - - - - -

Relevant External Links for CLTB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLTB Gene

mRNA expression in normal human tissues for CLTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CLTB Gene

This gene is overexpressed in Brain (20.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLTB Gene

SOURCE GeneReport for Unigene cluster for CLTB Gene Hs.484241

genes like me logo Genes that share expressions with CLTB: view

Expression partners for CLTB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLTB Gene

Orthologs for CLTB Gene

This gene was present in the common ancestor of animals.

Orthologs for CLTB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLTB 35
  • 92.06 (n)
  • 96.67 (a)
  • 90 (a)
(Canis familiaris)
Mammalia CLTB 35
  • 93.52 (n)
  • 98.1 (a)
  • 98 (a)
(Mus musculus)
Mammalia Cltb 35
  • 89.73 (n)
  • 95.26 (a)
Cltb 16
Cltb 36
  • 95 (a)
(Pan troglodytes)
Mammalia CLTB 35
  • 91.25 (n)
  • 88.12 (a)
(Rattus norvegicus)
Mammalia Cltb 35
  • 90.84 (n)
  • 95.26 (a)
(Monodelphis domestica)
Mammalia CLTB 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CLTB 36
  • 82 (a)
(Gallus gallus)
Aves CLTB 35
  • 79.39 (n)
  • 80.19 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia CLTB 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cltb 35
  • 69.77 (n)
  • 74.02 (a)
Str.3405 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68704 35
(Danio rerio)
Actinopterygii LOC100329879 35
  • 68.91 (n)
  • 64.9 (a)
FP102272.1 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.226 35
fruit fly
(Drosophila melanogaster)
Insecta Clc 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
CSA.79 36
  • 40 (a)
Species with no ortholog for CLTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLTB Gene

Gene Tree for CLTB (if available)
Gene Tree for CLTB (if available)

Paralogs for CLTB Gene

Paralogs for CLTB Gene

(1) SIMAP similar genes for CLTB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CLTB: view

Variants for CLTB Gene

Sequence variations from dbSNP and Humsavar for CLTB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs5866 -- 176,392,620(+) CGTGA(C/T)GGGGT utr-variant-3-prime, nc-transcript-variant
rs2303668 -- 176,397,323(+) CCCCA(C/T)AGCCC intron-variant
rs4296819 -- 176,416,515(+) CTCCG(C/G)CACCG utr-variant-5-prime, nc-transcript-variant
rs4377722 -- 176,395,376(+) GGGGG(G/T)CGGCC intron-variant
rs4868634 -- 176,412,131(+) AGATC(C/G)CGCCA intron-variant

Relevant External Links for CLTB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLTB Gene

Disorders for CLTB Gene

Relevant External Links for CLTB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CLTB Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLTB Gene

Publications for CLTB Gene

  1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PMID: 7713494) Ponnambalam S. … Parham P. (Genomics 1994) 2 3 23
  2. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. (PMID: 3267234) Jackson A.P. … Parham P. (J. Biol. Chem. 1988) 3 4
  3. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (PMID: 11889126) Legendre-Guillemin V. … McPherson P.S. (J. Biol. Chem. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. (PMID: 15533940) Chen C.-Y. … Brodsky F.M. (J. Biol. Chem. 2005) 3 4

Products for CLTB Gene

Sources for CLTB Gene

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