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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLTB Gene

protein-coding GIFtS: 62
GCID: GC05M175819

clathrin, light chain B

(Previous names: clathrin, light polypeptide (Lcb) )

Explore 5 diseases affiliated with
CLTB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Clathrin, Light Chain B¹ ²
Clathrin, Light Polypeptide (Lcb)¹ ²
Lcb¹ ³
LCB²
Clathrin Light Chain B²
Clathrin, Light Chain (Lcb)²

External Ids:	HGNC: 2091¹	Entrez Gene: 1212²	Ensembl: ENSG00000175416⁷	OMIM: 118970⁵	UniProtKB: P09497³

Export aliases for CLTB gene to outside databases

Previous GC identifers: GC05M176168 GC05M176638 GC05M175754 GC05M175800 GC05M175752 GC05M170744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLTB:

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component

of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during

receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to

function as regulatory elements. Alternative splicing results in multiple transcript variants. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: CLCB_HUMAN, P09497

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLTB gene promoter:
C/EBPbeta CUTL1 NF-E2 p45 C/EBPalpha Arnt E47 CREB deltaCREB Hand1 NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLTB promoter sequence

Search SABiosciences Chromatin IP Primers for CLTB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLTB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.2

CLTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLTB gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M175819: view genomic region (about GC identifiers)

Start:	175,819,456 bp from pter	End:	175,843,570 bp from pter
Size:	24,115 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLCB_HUMAN, P09497 (See protein sequence)

Recommended Name: Clathrin light chain B

Size: 229 amino acids; 25190 Da

Subunit: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via

N-terminus) with HIP1. Interacts with HIP1R

Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated

pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles

Secondary accessions: Q53Y37 Q6FHW1

Alternative splicing: 2 isoforms: P09497-1 P09497-2

Explore the universe of human proteins at neXtProt for CLTB: NX_P09497

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09497

CLTB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001825.1 NP_009028.1

ENSEMBL proteins:

ENSP00000309415 ENSP00000310812 ENSP00000424739 ENSP00000422978 ENSP00000427229

Reactome Protein details: P09497
Human Recombinant Protein Products for CLTB:

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	ProSpec Recombinant Protein for CLTB
	Uscn Proteins for CLTB

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005802	trans-Golgi network	IEA	--
GO:0030118	clathrin coat	NAS	3267234
GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA	--
GO:0030132	clathrin coat of coated pit	IEA	--
GO:0044459	plasma membrane part	--	--

CLTB for ontologies About GeneDecksing

CLTB Antibody Products:

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	Uscn ELISAs and CLIAs for CLTB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLTB for domains About GeneDecksing

1 InterPro domain/family:

IPR000996 Clathrin_L-chain

Graphical View of Domain Structure for InterPro Entry P09497

ProtoNet protein and cluster: P09497

1 Blocks protein family: IPB000996 Clathrin light chain

UniProtKB/Swiss-Prot: CLCB_HUMAN, P09497

Similarity: Belongs to the clathrin light chain family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CLCB_HUMAN, P09497

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Genatlas biochemistry entry for CLTB:

clathrin,light chain B (Lcb),component of coated vesicles and coated pits,translocated to plasma membrane through AP2

binding,also expressed in synaptic vesicles

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	15533940
GO:0042277	peptide binding	IEA	--

CLTB for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CLTB:

Decreased POU5F1-GFP protein e

Decreased homologous recombina

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLTB

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		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CLTB:
		hsa-miR-595 hsa-miR-362-3p hsa-miR-3184 hsa-miR-520a-5p hsa-miR-329 hsa-miR-423-5p hsa-miR-525-5p hsa-miR-2115

		SwitchGear 3'UTR luciferase reporter plasmid: CLTB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLTB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66			wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)	0.35

Formation of annular gap junctions

	Formation of annular gap junctions	1.00			Lysosomal degradation of gap junction plaques	0.92
	Gap junction degradation	0.92

Development Angiotensin signaling via beta-Arrestin

Development Angiotensin signaling via beta-Arrestin

1.00

Development_Angiotensin signaling via beta-Arrestin

0.96

Gap junction assembly

Gap junction trafficking

0.74

Gap junction trafficking and regulation

0.70

Transport of MHC II:Ii complex along Golgi to TGN

Endocytic Trafficking of EGFR

0.00

Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)

0.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CLTB

	Clathrin-dependent protein traffic
	Development Angiotensin signaling via beta-Arrestin

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLTB

	CTLA4 Signaling
	Endocytic Trafficking of EGFR
	Remodeling of Adherens Junctions

5 GeneGo (Thomson Reuters) Pathways for CLTB

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Development Angiotensin signaling via beta-Arrestin
	Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
	wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
	Transport Clathrin-coated vesicle cycle

1 BioSystems Pathway for CLTB

Arf1 pathway

5/6 Reactome Pathways for CLTB (see all 6)

	Gap junction degradation
	Gap junction trafficking
	Lysosomal degradation of gap junction plaques
	Membrane Trafficking
	Formation of annular gap junctions

5 Kegg Pathways (Kegg details for CLTB):

	Lysosome
	Endocytosis
	Endocrine and other factor-regulated calcium reabsorption
	Huntington's disease
	Bacterial invasion of epithelial cells

CLTB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CLTB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/77 Interacting proteins for CLTB (P09497^{2, 3} ENSP00000309415⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM1	P62158³, ENSP00000349467⁴	I2D: score=2 STRING: ENSP00000349467
CALM2	P62158³	I2D: score=2
CALM3	P62158³	I2D: score=2
PQBP1	O60828²^,³, ENSP00000365747⁴	MINT-63179 I2D: score=4 STRING: ENSP00000365747
CSNK2A2	P19784³, ENSP00000262506⁴	I2D: score=2 STRING: ENSP00000262506

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	NAS	--
GO:0016192	vesicle-mediated transport	IEA	--

CLTB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLTB
Search CenterWatch for drugs/clinical trials and news about CLTB / CLCB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLTB gene (2 alternative transcripts):

NM_001834.3 NM_007097.3

Unigene Cluster for CLTB:

Clathrin, light chain B

Hs.484241 [show with all ESTs]

Unigene Representative Sequence: NR_045724

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310418(uc003meh.3) ENST00000345807(uc003mei.3) ENST00000508425

ENST00000510734(uc011dfn.2) ENST00000502877 ENST00000507821 ENST00000509319

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CLTB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLTB
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CLTB:
		hsa-miR-595 hsa-miR-362-3p hsa-miR-3184 hsa-miR-520a-5p hsa-miR-329 hsa-miR-423-5p hsa-miR-525-5p hsa-miR-2115

		SwitchGear 3'UTR luciferase reporter plasmid: CLTB 3' UTR sequence

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Additional cDNA sequence:

AK300200.1 BC006332.2 BC006457.1 BT007028.1 CR536577.1 M20470.1 NR_045724.1

14 DOTS entries:

DT.115757 DT.100037858 DT.120886628 DT.120886599 DT.100745225 DT.100790255 DT.120886670 DT.97854602

DT.91688345 DT.100745226 DT.86793375 DT.97854597 DT.120886720 DT.95087046

24/182 AceView cDNA sequences (see all 182):

T63830 BM563208 AI186474 BI194540 BG054969 BF914881 F08079 AI355725

AW009410 BE676639 AA587195 BQ271549 BM713601 CB163616 BT007028 AI128183

NM_001834 BU859703 AW950247 T63628 NM_007097 F36758 BQ637226 BU944727

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CLTB (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:													-
SP2:													-										-
SP3:													-								-		-		-		-
SP4:													-				-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for CLTB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGGGCCT

About this image

CLTB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLTB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLTB

SOURCE GeneReport for Unigene cluster: Hs.484241

SABiosciences Custom PCR Arrays for CLTB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLTB Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLTB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CLTB gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cltb^{1 , 5}	clathrin, light polypeptide (Lcb)^{1, 5}	89.73(n)¹ 95.26(a)¹		13 (28.84 cM)⁵ 74325¹ NM_028870.3¹ NP_083146.1¹ 54592401⁵
chicken (Gallus gallus)	Aves	CLTB¹	clathrin, light chain B	81.16(n) 83.57(a)		416226 NM_001030609.1 NP_001025780.1
lizard (Anolis carolinensis)	Reptilia	CLTB⁶	--	74(a)	1 ↔ 1	GL343548.1(302366-325127)
African clawed frog (Xenopus laevis)	Amphibia	MGC68704²	hypothetical protein MGC68704	76.64(n)		BC060412.1
zebrafish (Danio rerio)	Actinopterygii	LOC100329879¹	clathrin light chain B-like	70.19(n) 67.79(a)		100329879 XM_002666797.2 XP_002666843.2
fruit fly (Drosophila melanogaster)	Insecta	Clc⁶	Clathrin light chain	34(a)	1 → many	3L(20234153-20236835)
worm (Caenorhabditis elegans)	Secernentea	clic-1⁶	Clathrin LIght Chain family member (clic-1)	22(a)	1 → many	V(7733604-7734892)

ENSEMBL Gene Tree for CLTB (if available)
TreeFam Gene Tree for CLTB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLTB gene

CLTA²

1 SIMAP similar gene for CLTB using alignment to 4 protein entries: CLCB_HUMAN (see all proteins):

CLTA

CLTB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60599265^1,2	C	--	175821652(+)	`CTACT-/AAAAAA`	1	--	int¹		2		NA CSA	4
rs181056735^1,2		--	175826004(+)	`ACACCC/TGGCTA`	1	--	int¹		0	--	--	--	--
rs148654790^1,2		--	175826110(+)	`CAAGTA/GCTGGG`	1	--	int¹		0	--	--	--	--
rs78849357^1,2	C	--	175826135(+)	`CCACCA/GTGACC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLTB (175819456 - 175843570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLTB: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLTB

DNA2.0 Custom Variant and Variant Library Synthesis for CLTB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLTB for disorders           About GeneDecksing

OMIM gene information: 118970    OMIM disorders: --

5 diseases for CLTB:    About MalaCards

acrodermatitis huntington's disease cholesterol schizophrenia

neuronitis

Human Genome Epidemiology (HuGE) Navigator: CLTB (3 documents)

Export disorders for CLTB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CLTB gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with CLTB)

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Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PubMed id 7713494)^{1, 3, 9} Ponnambalam S....Parham P. (1994)
Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. (PubMed id 15533940)^{1, 2} Chen C.-Y. and Brodsky F.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (PubMed id 11889126)^{1, 2} Legendre-Guillemin V.... McPherson P.S. (2002)
Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. (PubMed id 3267234)^{1, 2} Jackson A.P. and Parham P. (1988)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells. (PubMed id 21704113)¹ Greiner V.J....de Rocquigny H. (2011)
Human immunodeficiency virus type 1 and related prima te lentiviruses engage clathrin through Gag-Pol or Gag. (PubMed id 21289110)¹ Popov S....GAPttlinger H.G. (2011)
Clathrin facilitates the morphogenesis of retrovirus p articles. (PubMed id 21738476)¹ Zhang F....Bieniasz P.D. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1212	HGNC: 2091	AceView: CLTB	Ensembl:ENSG00000175416	euGenes: HUgn1212
ECgene: CLTB	Kegg: 1212	H-InvDB: CLTB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CLTB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CLTB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CLTB gene
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clathrin, light chain B

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clathrin, light chain B

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