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Aliases for CLTA Gene

Aliases for CLTA Gene

  • Clathrin, Light Chain A 2 3
  • Clathrin, Light Polypeptide (Lca) 2 3
  • LCA 3 4
  • Clathrin Light Chain A 3

External Ids for CLTA Gene

Summaries for CLTA Gene

Entrez Gene Summary for CLTA Gene

  • Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

GeneCards Summary for CLTA Gene

CLTA (Clathrin, Light Chain A) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include structural molecule activity and peptide binding. An important paralog of this gene is CLTB.

UniProtKB/Swiss-Prot for CLTA Gene

  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLTA Gene

Genomics for CLTA Gene

Genomic Location for CLTA Gene

Start:
36,190,856 bp from pter
End:
36,304,781 bp from pter
Size:
113,926 bases
Orientation:
Plus strand

Genomic View for CLTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLTA Gene

Regulatory Elements for CLTA Gene

Proteins for CLTA Gene

  • Protein details for CLTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09496-CLCA_HUMAN
    Recommended name:
    Clathrin light chain A
    Protein Accession:
    P09496
    Secondary Accessions:
    • A8K4W3
    • B4DIN1
    • F5H6N3
    • Q2XPN5
    • Q53XZ1

    Protein attributes for CLTA Gene

    Size:
    248 amino acids
    Molecular mass:
    27077 Da
    Quaternary structure:
    • Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis.

    Alternative splice isoforms for CLTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLTA Gene

Proteomics data for CLTA Gene at MOPED

Post-translational modifications for CLTA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys141, Lys223, and Lys242

No data available for DME Specific Peptides for CLTA Gene

Domains for CLTA Gene

Protein Domains for CLTA Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CLCA_HUMAN
Family:
  • Belongs to the clathrin light chain family.:
    • P09496
genes like me logo Genes that share domains with CLTA: view

No data available for Gene Families for CLTA Gene

Function for CLTA Gene

Molecular function for CLTA Gene

GENATLAS Biochemistry: clathrin,light chain A (Lca),component of coated vesicles and coated pits,translocated to plasma membrane through AP2 binding,also expressed in synaptic vesicles
UniProtKB/Swiss-Prot Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Gene Ontology (GO) - Molecular Function for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 21297582
GO:0032050 clathrin heavy chain binding IPI 4066749
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with CLTA: view
genes like me logo Genes that share phenotypes with CLTA: view

miRNA for CLTA Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLTA Gene

Localization for CLTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLTA Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLTA Gene COMPARTMENTS Subcellular localization image for CLTA gene
Compartment Confidence
cytosol 4
plasma membrane 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005905 coated pit --
GO:0016020 membrane IDA 19946888
GO:0016023 cytoplasmic membrane-bounded vesicle ISS --
genes like me logo Genes that share ontologies with CLTA: view

Pathways for CLTA Gene

genes like me logo Genes that share pathways with CLTA: view

Gene Ontology (GO) - Biological Process for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006897 endocytosis --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with CLTA: view

Transcripts for CLTA Gene

Unigene Clusters for CLTA Gene

Clathrin, light chain A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLTA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - -

Relevant External Links for CLTA Gene

GeneLoc Exon Structure for
CLTA
ECgene alternative splicing isoforms for
CLTA

Expression for CLTA Gene

mRNA expression in normal human tissues for CLTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLTA Gene

SOURCE GeneReport for Unigene cluster for CLTA Gene Hs.522114

genes like me logo Genes that share expressions with CLTA: view

Orthologs for CLTA Gene

This gene was present in the common ancestor of animals.

Orthologs for CLTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLTA 36
  • 99.33 (n)
  • 98.79 (a)
CLTA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLTA 36
  • 94.1 (n)
  • 96.71 (a)
CLTA 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLTA 36
  • 95.7 (n)
  • 98.79 (a)
CLTA 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clta 36
  • 92.61 (n)
  • 98.79 (a)
Clta 16
Clta 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLTA 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLTA 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clta 36
  • 91.67 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves CLTA 36
  • 77.22 (n)
  • 79.4 (a)
CLTA 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLTA 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5904 36
tropical clawed frog
(Silurana tropicalis)
Amphibia clta 36
  • 71.05 (n)
  • 83.68 (a)
zebrafish
(Danio rerio)
Actinopterygii clta 36
  • 73.45 (n)
  • 78.28 (a)
clta 37
  • 74 (a)
OneToOne
Dr.28835 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010608 36
  • 51.97 (n)
  • 44.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clc 36
  • 53.23 (n)
  • 44.5 (a)
Clc 37
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
CSA.79 37
  • 39 (a)
ManyToMany
Species with no ortholog for CLTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLTA Gene

ENSEMBL:
Gene Tree for CLTA (if available)
TreeFam:
Gene Tree for CLTA (if available)

Paralogs for CLTA Gene

Paralogs for CLTA Gene

Pseudogenes.org Pseudogenes for CLTA Gene

genes like me logo Genes that share paralogs with CLTA: view

Variants for CLTA Gene

Sequence variations from dbSNP and Humsavar for CLTA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3628 -- 36,211,878(+) CAAAC(C/T)TTTTT utr-variant-3-prime
rs13124 -- 36,211,785(+) CACCC(A/T)GTGGA utr-variant-3-prime
rs14917 -- 36,212,011(+) TCAAC(C/T)TGTGC utr-variant-3-prime
rs609025 -- 36,211,406(+) CACAG(C/T)GGTCT intron-variant
rs687075 -- 36,205,960(+) tttca(C/G)tgtgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLTA Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv893051 CNV Gain 21882294

Relevant External Links for CLTA Gene

HapMap Linkage Disequilibrium report
CLTA

Disorders for CLTA Gene

Relevant External Links for CLTA

Genetic Association Database (GAD)
CLTA
Human Genome Epidemiology (HuGE) Navigator
CLTA
genes like me logo Genes that share disorders with CLTA: view

No data available for UniProtKB/Swiss-Prot for CLTA Gene

Publications for CLTA Gene

  1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PMID: 7713494) Ponnambalam S. … Parham P. (Genomics 1994) 2 3 23
  2. Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. (PMID: 1975516) DeLuca-Flaherty C. … Hill B.L. (Cell 1990) 3 23
  3. Neuron-specific expression of high-molecular-weight clathrin light chain. (PMID: 2204686) Wong D.H. … Brodsky F.M. (J. Neurosci. 1990) 3 23
  4. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. (PMID: 3267234) Jackson A.P. … Parham P. (J. Biol. Chem. 1988) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for CLTA Gene

Sources for CLTA Gene

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