External Ids for CLTA Gene
Previous GeneCards Identifiers for CLTA Gene
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
GeneCards Summary for CLTA Gene
CLTA (Clathrin, Light Chain A) is a Protein Coding gene. Diseases associated with CLTA include leber congenital amaurosis. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include structural molecule activity and clathrin heavy chain binding. An important paralog of this gene is CLTB.
UniProtKB/Swiss-Prot for CLTA Gene
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles