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CLTA Gene

protein-coding   GIFtS: 65
GCID: GC09P036180

Clathrin, Light Chain A

(Previous names: clathrin, light polypeptide (Lca))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Clathrin, Light Chain A1 2
Clathrin, Light Polypeptide (Lca)1 2
LCA2
Clathrin Light Chain A2
Lca3

External Ids:    HGNC: 20901   Entrez Gene: 12112   Ensembl: ENSG000001227057   OMIM: 1189605   UniProtKB: P094963   

Export aliases for CLTA gene to outside databases

Previous GC identifers: GC09P036503 GC09P036360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLTA Gene:
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural
component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules
during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are
believed to function as regulatory elements. Alternative splicing results in multiple transcript variants.
Related pseudogenes have been identified on chromosomes 8 and 12. (provided by RefSeq, May 2010)

GeneCards Summary for CLTA Gene:
CLTA (clathrin, light chain A) is a protein-coding gene. Diseases associated with CLTA include huntington's disease, and hiv-1. GO annotations related to this gene include peptide binding and structural molecule activity. An important paralog of this gene is CLTB.

UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLTA gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   C/EBPalpha   GATA-1   E2F   E2F-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLTA promoter sequence
   Search Chromatin IP Primers for CLTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

CLTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLTA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P036180:  view genomic region     (about GC identifiers)

Start:
36,190,853 bp from pter      End:
36,304,778 bp from pter
Size:
113,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496 (See protein sequence)
Recommended Name: Clathrin light chain A  
Size: 248 amino acids; 27077 Da
Subunit: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with
CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis
Secondary accessions: A8K4W3 B4DIN1 F5H6N3 Q2XPN5 Q53XZ1
Alternative splicing: 5 isoforms:  P09496-1   P09496-2   P09496-3   P09496-4   P09496-5   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CLTA: NX_P09496

Explore proteomics data for CLTA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys141, Lys223, Lys242
  • Modification sites at PhosphoSitePlus

  • See CLTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001070145.1  NP_001171689.1  NP_001171690.1  NP_001171691.1  NP_001824.1  NP_009027.1  

    ENSEMBL proteins: 
     ENSP00000242284   ENSP00000419158   ENSP00000419746   ENSP00000242285   ENSP00000417698  
     ENSP00000379848   ENSP00000474266   ENSP00000401019   ENSP00000442869   ENSP00000437508  
    Reactome Protein details: P09496

    CLTA Human Recombinant Protein Products:

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    Novus Biologicals CLTA Proteins
    Novus Biologicals CLTA Lysates
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    CLTA Antibody Products:

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    Abcam antibodies for CLTA (P09496, P09497)
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    LSBio Antibodies in human, mouse, rat for CLTA

    CLTA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLTA
    Cloud-Clone Corp. CLIAs for CLTA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000996 Clathrin_L-chain

    Graphical View of Domain Structure for InterPro Entry P09496

    ProtoNet protein and cluster: P09496

    1 Blocks protein domain: IPB000996 Clathrin light chain

    UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496
    Similarity: Belongs to the clathrin light chain family


    CLTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLCA_HUMAN, P09496
    Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

         Genatlas biochemistry entry for CLTA:
    clathrin,light chain A (Lca),component of coated vesicles and coated pits,translocated to plasma membrane through
    AP2 binding,also expressed in synaptic vesicles

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI--
    GO:0032050clathrin heavy chain binding IPI4066749
    GO:0042277peptide binding IEA--
         
    CLTA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CLTA:
     Decreased POU5F1-GFP protein e  Decreased viability after Chla  Increased S DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLTA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLTA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLTA

    miRNA
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    miRTarBase miRNAs that target CLTA:
    hsa-mir-155-5p (MIRT020728), hsa-mir-23b-3p (MIRT046362), hsa-mir-124-3p (MIRT022724), hsa-mir-26b-5p (MIRT029517)

    Block miRNA regulation of human, mouse, rat CLTA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CLTA:
    hsa-miR-146a* hsa-miR-133a hsa-miR-1252 hsa-miR-133b hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidCLTA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CLTA
    Predesigned siRNA for gene silencing in human, mouse, rat CLTA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 6): CLTA (NM_001833)
    Sino Biological Human cDNA Clone for CLTA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLTA

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLCA_HUMAN, P09496: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane,
    coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005905coated pit ----
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--
    GO:0030118clathrin coat NAS3267234

    CLTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLTA About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Endocytic Trafficking of EGFR
    Endocytic Trafficking of EGFR0.36
    Cholesterol and Sphingolipids transport Influx to the early endosome in lung normal and CF 0.35
    Retrograde neurotrophin signalling0.36
    Recycling pathway of L10.33
    2Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    3Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    4Gap junction trafficking
    Gap junction trafficking0.93
    Formation of annular gap junctions0.00
    Gap junction trafficking and regulation0.93
    Gap junction degradation0.00
    Entry of Influenza Virion into Host Cell via Endocytosis0.00
    5Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLTA
        CTLA4 Signaling
    Endocytic Trafficking of EGFR
    Remodeling of Adherens Junctions

    5 GeneGo (Thomson Reuters) Pathways for CLTA
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Development Angiotensin signaling via beta-Arrestin
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle

    3 BioSystems Pathways for CLTA
        Synaptic Vesicle Pathway
    Arf1 pathway
    C-MYB transcription factor network


    Selected Reactome Pathways for CLTA (see all 7)
        Recycling pathway of L1
    Gap junction degradation
    Formation of annular gap junctions
    Retrograde neurotrophin signalling
    WNT5A-dependent internalization of FZD4


    Selected Kegg Pathways  (Kegg details for CLTA) (see all 6):
        Lysosome
    Endocytosis
    Synaptic vesicle cycle
    Endocrine and other factor-regulated calcium reabsorption
    Huntington's disease


    CLTA for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLTA
    Interactions:

        GeneGlobe Interaction Network for CLTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLTA (P094961, 2, 3 ENSP000002422854) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259521 I2D: score=3 
    TACC3Q9Y6A51, 2, 3, ENSP000003265504EBI-1171169,EBI-2554984 MINT-8144928 MINT-8145261 MINT-8151296 MINT-8145273 I2D: score=1 STRING: ENSP00000326550
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006897endocytosis IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007411axon guidance TAS--

    CLTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLTA (CLCA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLTA gene (6 alternative transcripts): 
    NM_001076677.2  NM_001184760.1  NM_001184761.1  NM_001184762.1  NM_001833.3  NM_007096.3  

    Unigene Cluster for CLTA:

    Clathrin, light chain A
    Hs.522114  [show with all ESTs]
    Unigene Representative Sequence: BM909587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345519 ENST00000464497 ENST00000470744 ENST00000242285 ENST00000466396
    ENST00000396603 ENST00000493185 ENST00000433436(uc003zzc.3 uc003zzd.3)
    ENST00000538225(uc011lpk.2 uc003zze.3 uc022bgo.1) ENST00000540080(uc022bgp.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CLTA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CLTA:
    hsa-miR-146a* hsa-miR-133a hsa-miR-1252 hsa-miR-133b hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidCLTA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLTA
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    GenScript: all cDNA clones in your preferred vector (see all 6): CLTA (NM_001833)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLTA
    Primer
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    OriGene qPCR primer pairs and template standards for CLTA
    OriGene qSTAR qPCR primer pairs in human, mouse for CLTA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLTA
      QuantiTect SYBR Green Assays in human, mouse, rat CLTA
      QuantiFast Probe-based Assays in human, mouse, rat CLTA

    Additional mRNA sequence: 

    AK225153.1 AK291078.1 AK295692.1 BC009201.2 BC019287.1 BT007170.1 DQ270158.1 M20471.1 
    M20472.1 

    Selected DOTS entries (see all 29):

    DT.87008359  DT.95348564  DT.92464231  DT.100885222  DT.100039126  DT.97862468  DT.121169356  DT.100885221 
    DT.100745308  DT.121169276  DT.95348538  DT.100885218  DT.100885226  DT.121169306  DT.100885220  DT.100885231 
    DT.100885236  DT.102835237  DT.121169250  DT.91661494  DT.92067484  DT.95348546  DT.95348552  DT.95348553 

    Selected AceView cDNA sequences (see all 836):

    AA573459 BE267700 CB045173 BU543561 AI923790 BU627562 BQ130553 AW130336 
    CA421637 R84577 CA431761 BU553491 AA418657 BQ925375 BX395619 AA411500 
    BM755789 BQ228250 BQ060998 BM503421 BG686730 BQ064217 BM460279 BU618391 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLTA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                              
    SP2:                                                  -                           
    SP3:                          -     -                                             
    SP4:                                            -                                 
    SP5:                                            -     -                           


    ECgene alternative splicing isoforms for CLTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLTA expression in normal human tissues (normalized intensities)      CLTA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCTTCCT
    CLTA Expression
    About this image


    CLTA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CLTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522114
        Custom PCR Arrays for CLTA
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CLTA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLTA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLTA gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clta1 , 5 clathrin, light polypeptide (Lca)1, 5 92.61(n)1
    98.79(a)1
      4 (23.09 cM)5
    127571  NM_001080385.11  NP_001073854.11 
     440044525 
    chicken
    (Gallus gallus)
    Aves CLTA1 clathrin, light chain A 77.22(n)
    79.4(a)
      427284  NM_001039313.1  NP_001034402.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLTA6
    clathrin, light chain A
    81(a)
    1 ↔ 1
    GL343201.1(2314313-2340774)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59042 Xenopus laevis transcribed sequence with moderate similarity more 76.91(n)    CD360667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.288352 Danio rerio cDNA clone MGC73358 IMAGE4144130, complete more 79.24(n)    BC060939.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clc1 Clathrin light chain 53.23(n)
    44.5(a)
      40221  NM_079454.3  NP_524178.2 


    ENSEMBL Gene Tree for CLTA (if available)
    TreeFam Gene Tree for CLTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLTA gene
    CLTB2  
    Selected SIMAP similar genes for CLTA using alignment to 4 protein entries:     CLCA_HUMAN (see all proteins) (see all similar genes):
    UBXN4    FTSJ2    RHBG    DNAPTP3    RBP7    CALM2
    LINC00999    TUBA1C    C12orf76    ATL2    C9orf85    TBCB
    PFKFB3    RQCD1    TM2D1    C3orf64    DSERG1    SH2B3

    CLTA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CLTA
    PGOHUM00000239638 PGOHUM00000249255


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLTA (see all 473)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808382531,2
    --36188980(+) GATCAA/CAACAT 6 -- us2k10--------
    rs792683771,2
    C,F--36188997(+) ATCTGA/CAACCT 6 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1853330921,2
    C--36189262(+) GAAATC/TATCCG 6 -- us2k10--------
    rs1900892991,2
    --36189287(+) ATTCCA/TCCAAT 6 -- us2k10--------
    rs1830790511,2
    --36189385(+) TGCATC/TTCCCC 6 -- us2k10--------
    rs70212661,2
    C,F,A,H--36189392(+) CCCCAA/GAAAGA 6 -- us2k14Minor allele frequency- G:0.01NS EA 418
    rs1914954621,2
    --36189411(+) TGTTCC/TGGAGC 6 -- us2k10--------
    rs1838030721,2
    --36189419(+) AGCTAC/TTACTG 6 -- us2k10--------
    rs752394651,2
    C,F--36189439(+) ACTAAA/GAGTTG 6 -- us2k11Minor allele frequency- G:0.04WA 118
    rs37396081,2
    C,F,A,H--36189647(-) TATGAA/GCCATA 6 -- us2k1 tfbs310Minor allele frequency- G:0.08NS EA NA WA 782

    HapMap Linkage Disequilibrium report for CLTA (36190853 - 36304778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLTA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34080CNV Loss18971310
    nsv893049CNV Gain21882294
    nsv893051CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLTA
    DNA2.0 Custom Variant and Variant Library Synthesis for CLTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118960    OMIM disorders: --

    8 diseases for CLTA:    About MalaCards
    huntington's disease    hiv-1    parkinson's disease    cystic fibrosis
    sarcoma    malaria    neuronitis    prostatitis


    CLTA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CLTA
    Human Genome Epidemiology (HuGE) Navigator: CLTA (3 documents)

    Export disorders for CLTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLTA gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with CLTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PubMed id 7713494)1, 3, 9 Ponnambalam S....Parham P. (Genomics 1994)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. (PubMed id 3267234)1, 2 Jackson A.P. and Parham P. (J. Biol. Chem. 1988)
    6. Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. (PubMed id 1975516)1, 9 DeLuca-Flaherty C....Hill B.L. (Cell 1990)
    7. Neuron-specific expression of high-molecular-weight clathrin light chain. (PubMed id 2204686)1, 9 Wong D.H....Brodsky F.M. (J. Neurosci. 1990)
    8. Noradrenaline induces binding of Clathrin light chain A to I+1-adrenoceptors in the human prostate. (PubMed id 23460120)1 Hennenberg M....Gratzke C. (Prostate 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1211 HGNC: 2090 AceView: CLTA Ensembl:ENSG00000122705 euGenes: HUgn1211
    ECgene: CLTA Kegg: 1211 H-InvDB: CLTA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLTA gene:
    Search GeneIP for patents involving CLTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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