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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLTA Gene

protein-coding   GIFtS: 61
GCID: GC09P036180

clathrin, light chain A

(Previous names: clathrin, light polypeptide (Lca) )
 Explore 5 diseases affiliated with
CLTA via our new
 Human Malady Compendium 
Biological research products
for CLTA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Clathrin, Light Chain A1 2
Clathrin, Light Polypeptide (Lca)1 2
Lca1 3
LCA2
Clathrin Light Chain A2

External Ids:    HGNC: 20901   Entrez Gene: 12112   Ensembl: ENSG000001227057   OMIM: 1189605   UniProtKB: P094963   

Export aliases for CLTA gene to outside databases

Previous GC identifers: GC09P036503 GC09P036360


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLTA:
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component
of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during
receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to
function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes
have been identified on chromosomes 8 and 12. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLTA gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   C/EBPalpha   GATA-1   E2F   E2F-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLTA promoter sequence
   Search SABiosciences Chromatin IP Primers for CLTA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

CLTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLTA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P036180:  view genomic region     (about GC identifiers)

Start:
36,190,853 bp from pter      End:
36,304,778 bp from pter
Size:
113,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496 (See protein sequence)
Recommended Name: Clathrin light chain A  
Size: 248 amino acids; 27077 Da
Subunit: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY;
the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis
Subcellular location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated
pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles
Secondary accessions: A8K4W3 B4DIN1 Q2XPN5 Q53XZ1
Alternative splicing: 4 isoforms:  P09496-1   P09496-2   P09496-3   P09496-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLTA: NX_P09496

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09496

  • CLTA Protein expression data from MOPED and PaxDb:    About this image 
    CLTA Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001070145.1  NP_001171689.1  NP_001171690.1  NP_001171691.1  NP_001824.1  NP_009027.1  

    ENSEMBL proteins: 
     ENSP00000242284   ENSP00000419158   ENSP00000419746   ENSP00000242285   ENSP00000417698  
     ENSP00000379848   ENSP00000420425   ENSP00000401019   ENSP00000442869   ENSP00000437508  
    Reactome Protein details: P09496
    Human Recombinant Protein Products for CLTA: 
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    ProSpec Recombinant Protein for CLTA
    Uscn Proteins for CLTA

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005905coated pit ----
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--
    GO:0030118clathrin coat NAS3267234

    CLTA for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLTA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000996 Clathrin_L-chain

    Graphical View of Domain Structure for InterPro Entry P09496

    ProtoNet protein and cluster: P09496

    1 Blocks protein family: IPB000996 Clathrin light chain

    UniProtKB/Swiss-Prot: CLCA_HUMAN, P09496
    Similarity: Belongs to the clathrin light chain family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLCA_HUMAN, P09496
    Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

         Genatlas biochemistry entry for CLTA:
    clathrin,light chain A (Lca),component of coated vesicles and coated pits,translocated to plasma membrane through AP2
    binding,also expressed in synaptic vesicles

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
    GO:0042277peptide binding IEA--
         
    CLTA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CLTA:
     Decreased POU5F1-GFP protein e  Decreased viability after Chla  Increased S DNA content  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLTA 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLTA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    Axon guidance1.00
    Recycling pathway of L10.15
    Developmental Biology0.69
    Signal transduction by L10.12
    L1CAM interactions0.39
    2Transport of MHC II:Ii complex along Golgi to TGN
    Internalization of MHC II:Ii clathrin coated vesicle0.52
    EGFR downregulation0.00
    Endocytic Trafficking of EGFR0.00
    Retrograde neurotrophin signalling0.00
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)0.00
    3Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic1.00
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport_Clathrin-coated vesicle cycle0.66
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35
    4Clathrin derived vesicle budding
    Clathrin derived vesicle budding1.00
    Golgi Associated Vesicle Biogenesis0.89
    trans-Golgi Network Vesicle Budding1.00
    Lysosome Vesicle Biogenesis0.39
    5Signaling by FGFR
    Signaling by EGFR0.84
    NGF signalling via TRKA from the plasma membrane0.70
    Signaling by EGFR in Cancer0.83
    Signalling by NGF0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CLTA
        Clathrin-dependent protein traffic
    Development Angiotensin signaling via beta-Arrestin

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLTA
        CTLA4 Signaling
    Endocytic Trafficking of EGFR
    Remodeling of Adherens Junctions

    5 GeneGo (Thomson Reuters) Pathways for CLTA
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Development Angiotensin signaling via beta-Arrestin
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle

    3 BioSystems Pathways for CLTA 
        Synaptic Vesicle Pathway
    Arf1 pathway
    C-MYB transcription factor network

    5/27        Reactome Pathways for CLTA (see all 27)
        L1CAM interactions
    Developmental Biology
    Internalization of MHC II:Ii clathrin coated vesicle
    Membrane Trafficking
    Clathrin derived vesicle budding


    5         Kegg Pathways  (Kegg details for CLTA):
        Lysosome
    Endocytosis
    Endocrine and other factor-regulated calcium reabsorption
    Huntington's disease
    Bacterial invasion of epithelial cells


    CLTA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for CLTA (P094962, 3 ENSP000002422854) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259521 I2D: score=3 
    TACC3Q9Y6A52, 3, ENSP000003265504MINT-8144928 MINT-8145261 MINT-8151296 MINT-8145273 I2D: score=1 STRING: ENSP00000326550
    CLTCQ006102, 3, ENSP000002691224MINT-6802072 MINT-8145273 I2D: score=2 STRING: ENSP00000269122
    CKAP5Q140082, ENSP000003465664MINT-8144928 MINT-8145261 MINT-8145273 STRING: ENSP00000346566
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=3 STRING: ENSP00000363970
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS--
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006897endocytosis IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007411axon guidance TAS--

    CLTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLTA
    Search CenterWatch for drugs/clinical trials and news about CLTA / CLCA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLTA gene (6 alternative transcripts): 
    NM_001076677.2  NM_001184760.1  NM_001184761.1  NM_001184762.1  NM_001833.3  NM_007096.3  

    Unigene Cluster for CLTA:

    Clathrin, light chain A
    Hs.522114  [show with all ESTs]
    Unigene Representative Sequence: BM909587
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345519 ENST00000464497 ENST00000470744 ENST00000242285 ENST00000466396
    ENST00000396603 ENST00000462562 ENST00000493185 ENST00000433436(uc003zzc.3 uc003zzd.3)
    ENST00000538225(uc011lpk.2 uc003zze.3 uc022bgo.1) ENST00000540080(uc022bgp.1)


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    hsa-miR-146a* hsa-miR-133a hsa-miR-1252 hsa-miR-133b hsa-miR-3159
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    Additional cDNA sequence: 

    AK225153.1 AK291078.1 AK295692.1 BC009201.2 BC019287.1 BT007170.1 DQ270158.1 M20471.1 
    M20472.1 

    24/29 DOTS entries (see all 29):

    DT.87008359  DT.95348564  DT.92464231  DT.100885222  DT.100039126  DT.97862468  DT.121169356  DT.100885221 
    DT.100745308  DT.121169276  DT.95348538  DT.100885218  DT.100885226  DT.121169306  DT.100885220  DT.100885231 
    DT.100885236  DT.102835237  DT.121169250  DT.91661494  DT.92067484  DT.95348546  DT.95348552  DT.95348553 

    24/836 AceView cDNA sequences (see all 836):

    BF793676 AA421641 CF126304 CB160264 BE350557 BM969110 BQ671537 BQ643340 
    BM724006 CA422812 BM503259 BE797068 BE350466 BU728000 T40395 BI222698 
    BM985442 AW960462 NM_001833 AI308051 BM974722 BE042722 CR599344 CA454415 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLTA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                              
    SP2:                                                  -                           
    SP3:                          -     -                                             
    SP4:                                            -                                 
    SP5:                                            -     -                           


    ECgene alternative splicing isoforms for CLTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCTTCCT
    CLTA Expression
    About this image
    See CLTA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLTA

    SOURCE GeneReport for Unigene cluster: Hs.522114
        SABiosciences Custom PCR Arrays for CLTA

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CLTA gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLTA1 clathrin, light chain A 76.94(n)
    79.15(a)
      427284  NM_001039313.1  NP_001034402.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLTA6
    --
    79(a)
    1 ↔ 1
    GL343201.1(2314423-2340205)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59042 Xenopus laevis transcribed sequence with moderate similarity more 76.91(n)    CD360667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.288352 Danio rerio cDNA clone MGC73358 IMAGE4144130, complete more 79.24(n)    BC060939.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clc1 Clathrin light chain 51.3(n)
    40.41(a)
      40221  NM_001170009.1  NP_001163480.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clic-16
    Clathrin LIght Chain family member (clic-1)
    22(a)
    1 → many
    V(7733604-7734892)


    ENSEMBL Gene Tree for CLTA (if available)
    TreeFam Gene Tree for CLTA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLTA gene
    CLTB2  
    18/43 SIMAP similar genes for CLTA using alignment to 5 protein entries:     CLCA_HUMAN (see all proteins) (see all similar genes):
    UBXN4    FTSJ2    RHBG    DNAPTP3    CALM2    TUBA1C
    C12orf76    ATL2    C9orf85    LOC100996300    PFKFB3    RQCD1
    C3orf64    DSERG1    KIAA0101    SH2B3    FP6778    GALK2

    CLTA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CLTA
    PGOHUM00000239638 PGOHUM00000249255


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/375 NCBI SNPs in CLTA are shown (see all 375    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808382531,2
    --36188980(+) GATCAA/CAACAT 6 -- us2k10--------
    rs792683771,2
    C,F--36188997(+) ATCTGA/CAACCT 6 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1853330921,2
    --36189262(+) GAAATC/TATCCG 6 -- us2k10--------
    rs1900892991,2
    --36189287(+) ATTCCA/TCCAAT 6 -- us2k10--------
    rs1830790511,2
    --36189385(+) TGCATC/TTCCCC 6 -- us2k10--------
    rs70212661,2
    C,F,A,H--36189392(+) CCCCAA/GAAAGA 6 -- us2k14Minor allele frequency- G:0.01NS EA 418
    rs1914954621,2
    --36189411(+) TGTTCC/TGGAGC 6 -- us2k10--------
    rs1838030721,2
    --36189419(+) AGCTAC/TTACTG 6 -- us2k10--------
    rs752394651,2
    F--36189439(+) ACTAAA/GAGTTG 6 -- us2k11Minor allele frequency- G:0.04WA 118
    rs37396081,2
    C,F,A,H--36189647(-) TATGAA/GCCATA 6 -- us2k1 tfbs310Minor allele frequency- G:0.08NS EA NA WA 782

    HapMap Linkage Disequilibrium report for CLTA (36190853 - 36304778 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CLTA
         1 CNV: 47924

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLTA
    DNA2.0 Custom Variant and Variant Library Synthesis for CLTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLTA for disorders           About GeneDecksing

    OMIM gene information: 118960    OMIM disorders: --

    5 diseases for CLTA:    About MalaCards
    huntington's disease    parkinson's disease    sarcoma    cholesterol
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CLTA (3 documents)

    Export disorders for CLTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLTA gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CLTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PubMed id 7713494)1, 3, 9 Ponnambalam S....Parham P. (1994)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. (PubMed id 3267234)1, 2 Jackson A.P. and Parham P. (1988)
    5. Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. (PubMed id 1975516)1, 9 DeLuca-Flaherty C....Hill B.L. (1990)
    6. Neuron-specific expression of high-molecular-weight clathrin light chain. (PubMed id 2204686)1, 9 Wong D.H....Brodsky F.M. (1990)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1211 HGNC: 2090 AceView: CLTA Ensembl:ENSG00000122705 euGenes: HUgn1211
    ECgene: CLTA Kegg: 1211 H-InvDB: CLTA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLTA gene:
    Search GeneIP for patents involving CLTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in CLTA promoter
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