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Aliases for CLTA Gene

Aliases for CLTA Gene

  • Clathrin Light Chain A 2 3
  • Clathrin, Light Chain A 2 3 5
  • Clathrin, Light Polypeptide (Lca) 2 3
  • LCA 3 4

External Ids for CLTA Gene

Previous GeneCards Identifiers for CLTA Gene

  • GC09P036503
  • GC09P036360

Summaries for CLTA Gene

Entrez Gene Summary for CLTA Gene

  • Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

GeneCards Summary for CLTA Gene

CLTA (Clathrin Light Chain A) is a Protein Coding gene. Diseases associated with CLTA include leber congenital amaurosis. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include structural molecule activity and clathrin heavy chain binding. An important paralog of this gene is CLTB.

UniProtKB/Swiss-Prot for CLTA Gene

  • Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLTA Gene

Genomics for CLTA Gene

Regulatory Elements for CLTA Gene

Promoters for CLTA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLTA on UCSC Golden Path with GeneCards custom track

Genomic Location for CLTA Gene

Chromosome:
9
Start:
36,190,856 bp from pter
End:
36,304,781 bp from pter
Size:
113,926 bases
Orientation:
Plus strand

Genomic View for CLTA Gene

Genes around CLTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLTA Gene

Proteins for CLTA Gene

  • Protein details for CLTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09496-CLCA_HUMAN
    Recommended name:
    Clathrin light chain A
    Protein Accession:
    P09496
    Secondary Accessions:
    • A8K4W3
    • B4DIN1
    • F5H6N3
    • Q2XPN5
    • Q53XZ1

    Protein attributes for CLTA Gene

    Size:
    248 amino acids
    Molecular mass:
    27077 Da
    Quaternary structure:
    • Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis.

    Alternative splice isoforms for CLTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLTA Gene

Proteomics data for CLTA Gene at MOPED

Post-translational modifications for CLTA Gene

  • Ubiquitination at Lys 141
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CLTA Gene

Domains & Families for CLTA Gene

Protein Domains for CLTA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLTA Gene

Graphical View of Domain Structure for InterPro Entry

P09496

UniProtKB/Swiss-Prot:

CLCA_HUMAN :
  • Belongs to the clathrin light chain family.
Family:
  • Belongs to the clathrin light chain family.
genes like me logo Genes that share domains with CLTA: view

No data available for Gene Families for CLTA Gene

Function for CLTA Gene

Molecular function for CLTA Gene

GENATLAS Biochemistry:
clathrin,light chain A (Lca),component of coated vesicles and coated pits,translocated to plasma membrane through AP2 binding,also expressed in synaptic vesicles
UniProtKB/Swiss-Prot Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Gene Ontology (GO) - Molecular Function for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA,IBA --
genes like me logo Genes that share ontologies with CLTA: view
genes like me logo Genes that share phenotypes with CLTA: view

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLTA Gene

Localization for CLTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLTA Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLTA Gene COMPARTMENTS Subcellular localization image for CLTA gene
Compartment Confidence
cytosol 5
endosome 4
golgi apparatus 4
lysosome 4
plasma membrane 4
vacuole 4

Gene Ontology (GO) - Cellular Components for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0030118 clathrin coat NAS 3267234
GO:0030130 clathrin coat of trans-Golgi network vesicle IEA --
GO:0030136 clathrin-coated vesicle IEA --
GO:0032588 trans-Golgi network membrane TAS --
genes like me logo Genes that share ontologies with CLTA: view

Pathways & Interactions for CLTA Gene

genes like me logo Genes that share pathways with CLTA: view

Gene Ontology (GO) - Biological Process for CLTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with CLTA: view

No data available for SIGNOR curated interactions for CLTA Gene

Drugs & Compounds for CLTA Gene

No Compound Related Data Available

Transcripts for CLTA Gene

Unigene Clusters for CLTA Gene

Clathrin, light chain A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLTA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - -

Relevant External Links for CLTA Gene

GeneLoc Exon Structure for
CLTA
ECgene alternative splicing isoforms for
CLTA

Expression for CLTA Gene

mRNA expression in normal human tissues for CLTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLTA Gene

This gene is overexpressed in Brain (23.0) and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLTA Gene



SOURCE GeneReport for Unigene cluster for CLTA Gene Hs.522114

genes like me logo Genes that share expression patterns with CLTA: view

Protein tissue co-expression partners for CLTA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLTA Gene

Orthologs for CLTA Gene

This gene was present in the common ancestor of animals.

Orthologs for CLTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLTA 36
  • 99 (a)
OneToOne
CLTA 35
  • 99.33 (n)
  • 98.79 (a)
cow
(Bos Taurus)
Mammalia CLTA 35
  • 94.1 (n)
  • 96.71 (a)
CLTA 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLTA 36
  • 99 (a)
OneToOne
CLTA 35
  • 95.7 (n)
  • 98.79 (a)
mouse
(Mus musculus)
Mammalia Clta 16
Clta 36
  • 99 (a)
OneToOne
Clta 35
  • 92.61 (n)
  • 98.79 (a)
oppossum
(Monodelphis domestica)
Mammalia CLTA 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLTA 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clta 35
  • 91.67 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves CLTA 35
  • 77.22 (n)
  • 79.4 (a)
CLTA 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLTA 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5904 35
tropical clawed frog
(Silurana tropicalis)
Amphibia clta 35
  • 71.05 (n)
  • 83.68 (a)
zebrafish
(Danio rerio)
Actinopterygii clta 35
  • 73.45 (n)
  • 78.28 (a)
Dr.28835 35
clta 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010608 35
  • 51.97 (n)
  • 44.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clc 35
  • 53.23 (n)
  • 44.5 (a)
Clc 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.79 36
  • 39 (a)
ManyToMany
Species with no ortholog for CLTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLTA Gene

ENSEMBL:
Gene Tree for CLTA (if available)
TreeFam:
Gene Tree for CLTA (if available)

Paralogs for CLTA Gene

Paralogs for CLTA Gene

Pseudogenes.org Pseudogenes for CLTA Gene

genes like me logo Genes that share paralogs with CLTA: view

Variants for CLTA Gene

Sequence variations from dbSNP and Humsavar for CLTA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1803901 -- 36,204,095(+) AGCAG(A/C)GTGGA nc-transcript-variant, reference, missense
rs2274523 -- 36,191,007(+) TGGGT(C/T)GGTTG intron-variant, nc-transcript-variant, utr-variant-5-prime
rs2274524 -- 36,191,152(+) CCGGC(C/T)GCGGC intron-variant, nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs2772223 -- 36,198,848(+) agcct(A/C/T)ggcga intron-variant
rs1999005 -- 36,190,201(+) GCAAG(G/T)GATCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLTA Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv893051 CNV Gain 21882294

Variation tolerance for CLTA Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLTA Gene

HapMap Linkage Disequilibrium report
CLTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLTA Gene

Disorders for CLTA Gene

MalaCards: The human disease database

(1) MalaCards diseases for CLTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search CLTA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLTA

Genetic Association Database (GAD)
CLTA
Human Genome Epidemiology (HuGE) Navigator
CLTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLTA
genes like me logo Genes that share disorders with CLTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLTA Gene

Publications for CLTA Gene

  1. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). (PMID: 7713494) Ponnambalam S. … Parham P. (Genomics 1994) 2 3 23 67
  2. Neuron-specific expression of high-molecular-weight clathrin light chain. (PMID: 2204686) Wong D.H. … Brodsky F.M. (J. Neurosci. 1990) 3 23
  3. Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. (PMID: 1975516) DeLuca-Flaherty C. … Hill B.L. (Cell 1990) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CLTA Gene

Sources for CLTA Gene

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