CLSTN1 Gene
protein-coding GIFtS: 56
GCID: GC01M009789
|
|
calsyntenin 1
| |
Aliases
for CLSTN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calsyntenin 11 2 | | Alcadein-Alpha1 | | CDHR121 2 | | Alcalpha11 | | CSTN11 2 | | Alcalpha21 | | KIAA09111 3 | | Cadherin-Related Family Member 122 | | Alzheimer-Related Cadherin-Like Protein2 3 | | Calsyntenin-11 | | Non-Classical Cadherin XB31alpha2 3 | | Non-Classical Cadherin XB31alpha12 | | ALC-ALPHA2 | | Alc-Alpha1 | | PIK3CD2 | | Alcadein-Alpha1 | | XB31alpha2 | | CS13 | | Alcadein Alpha 12 | | |
Export aliases for CLSTN1 gene to outside databasesPrevious GC identifers: GC01M009751 GC01M009632 GC01M009398 GC01M009498 GC01M009723 GC01M009711 GC01M008945 |
Summaries
for CLSTN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CSTN1_HUMAN, O94985Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complexformation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APPfragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably throughstabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppressesAPBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competingwith AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity)
 summary
for CLSTN1: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for CLSTN1
|
Genomic Views
for CLSTN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLSTN1 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 Tal-1beta E47 Nkx3-1 v2 AREB6 RORalpha1 Nkx3-1 v3 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLSTN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLSTN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22CLSTN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M009789: view genomic region
(about GC identifiers)
Start:
|
9,789,079 bp from pter |
End:
|
9,884,584 bp from pter |
Size:
|
95,506 bases |
Orientation:
|
minus strand |
|
Proteins
for CLSTN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSTN1_HUMAN, O94985 (See
protein sequence)Recommended Name: Calsyntenin-1 precursor Size: 981 amino acids; 109793 Da
Subunit: Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts withPSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metabolism.Interacts with KLC1 and APBB1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane.Cell projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (Bysimilarity). Nucleus. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitorysynapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1
Sequence caution: Sequence=BAA74934.2; Type=Erroneous initiation;
Secondary accessions: A8K183 Q5SR52 Q5UE58 Q71MN0 Q8N4K9Alternative splicing: 2 isoforms: O94985-1 O94985-2 Explore the universe of human proteins at neXtProt for CLSTN1: NX_O94985
Post-translational modifications:
Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular(soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavagecatalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in theextracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in thetripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94985
CLSTN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001009566.1 NP_055759.3
ENSEMBL proteins: ENSP00000366513 ENSP00000401934 ENSP00000354997 ENSP00000366502 ENSP00000443796
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
CLSTN1 for ontologies About GeneDecksing
CLSTN1 Antibody Products:
Assay Products for CLSTN1: |
Protein
Domains /
Families
for CLSTN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLSTN1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94985ProtoNet protein and cluster: O94985 1 Blocks protein family: IPB002126 Cadherin
UniProtKB/Swiss-Prot: CSTN1_HUMAN, O94985Domain: The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca(2+) (Bysimilarity)Similarity: Contains 2 cadherin domains |
Function
for CLSTN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSTN1_HUMAN, O94985Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complexformation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APPfragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably throughstabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppressesAPBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competingwith AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CLSTN1 (NM_014944) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLSTN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLSTN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLSTN1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CLSTN1 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Clstn1 (no phenotypes)
CLSTN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CLSTN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 Tocris Bioscience Pathways for CLSTN1 (see all 9)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLSTN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for CLSTN1 (O949852, 3 ENSP000003665134) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007156 | homophilic cell adhesion |
IEA | -- |
CLSTN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLSTN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for CLSTN1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | BAG 956 | Dual PI 3-kinase and PDK1 inhibitor | [853910-02-8] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
1 HMDB Compound for CLSTN1 About this table
Search CenterWatch for drugs/clinical trials and news about CLSTN1 / CSTN1
|
Transcripts
for CLSTN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLSTN1 gene (2 alternative transcripts): NM_001009566.1 NM_014944.3 Unigene Cluster for CLSTN1: Calsyntenin 1 Hs.29665 [show with all ESTs]Unigene Representative Sequence: AB0207187 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377298(uc001aqh.3 uc001aqi.3 uc010oag.2) ENST00000477264(uc001aqf.3)
ENST00000435891 ENST00000361311 ENST00000464286 ENST00000377288 ENST00000539822
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CLSTN1 (NM_014944) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLSTN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLSTN1 |
Additional cDNA sequence: AB020718.1 AF438482.1 AK000605.1 AK001591.1 AK056820.1 AK225500.1 AK289798.1 AK304813.1 AY545556.1 AY753301.1 BC033902.2 24/35 DOTS entries (see all 35): DT.101984929 DT.100032241 DT.100828020 DT.97862894 DT.220773 DT.92454072 DT.92454050 DT.100828019 DT.121376562 DT.121376797 DT.121376689 DT.92454078 DT.86847311 DT.100828018 DT.100040352 DT.121376609 DT.100828024 DT.121376787 DT.102837437 DT.121376582 DT.95243538 DT.97793918 DT.100688358 DT.121376612 24/699 AceView cDNA sequences (see all 699): AU279459 T30910 BM835758 AU279873 AK056820 BG654738 BQ882651 BP366621 AI140418 AB020718 BM799419 CB154656 BQ881255 AI953849 BQ640541 BM310625 BF062494 AI638337 BQ000027 H26477 CA941135 CA943680 BM670671 BP356317
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CLSTN1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | |
| SP5: | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLSTN1
|
Expression
for CLSTN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLSTN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAGGTCAGA
About this image
See CLSTN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLSTN1
SOURCE GeneReport for Unigene cluster: Hs.29665
UniProtKB/Swiss-Prot: CSTN1_HUMAN, O94985Tissue specificity: Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta.Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level)
SABiosciences Custom PCR Arrays for CLSTN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLSTN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLSTN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLSTN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLSTN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLSTN1 |
Orthologs
for CLSTN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CLSTN1 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CLSTN11 |
calsyntenin 1 |
77.96(n)
86.05(a) |
|
395372 NM_001197050.1 NP_001183979.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CLSTN16 |
-- |
82(a) |
1 ↔ 1 |
LGh(105838-154502) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC052116.12 |
-- |
77.85(n) |
|
393986 BC052116.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
calsyntenin-13 |
calcium-dependent cell-cell adhesion
calcium-dependent more |
29(a) |
|
102D4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
casy-11 |
Protein CASY-1 |
44.92(n)
33.45(a) |
|
174006 NM_001025939.4 NP_001021110.1 |
ENSEMBL Gene Tree for CLSTN1 (if available)
TreeFam Gene Tree for CLSTN1 (if available) |
Paralogs
for CLSTN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLSTN1 gene
- CLSTN32 CLSTN22
2 SIMAP similar genes for CLSTN1 using alignment to 3 protein entries: CSTN1_HUMAN (see all proteins):CLSTN2 CLSTN3
CLSTN1 for paralogs About GeneDecksing
|
Genomic Variants
for CLSTN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLSTN1 (9789079 - 9884584 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CLSTN1
1 CNV: 34841 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLSTN1 |
|
Disorders
/ Diseases
for CLSTN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLSTN1 for disorders About GeneDecksing
OMIM gene information: 611321
OMIM disorders: --
9  diseases for CLSTN1: About MalaCardsproliferative diabetic retinopathy diabetic retinopathy corneal dystrophy intrahepatic cholangiocarcinoma
neurodegenerative disease cholangiocarcinoma alzheimer's disease neuroblastoma
neuronitis
Export disorders for CLSTN1 gene to outside databases
|
Publications
for CLSTN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLSTN1 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with CLSTN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. (PubMed id 17332754)1, 2 Araki Y.... Suzuki T. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. (PubMed id 15037614)1, 2 Araki Y.... Suzuki T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Novel cadherin-related membrane proteins, Alcadeins, enhance the X11- like protein-mediated stabilization of amyloid beta-protein precursor metabolism. (PubMed id 12972431)1, 2 Araki Y....Suzuki T. (2003)
- Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. (PubMed id 11161476)1, 9 Vogt L....Sonderegger P. (2001)
- The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns. (PubMed id 12498782)2, 9 Hintsch G.... Sonderegger P. (2002)
- Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Ab production. (PubMed id 22434822)1 Vagnoni A....Miller C.C. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for CLSTN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CLSTN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CLSTN1 gene
(According to HUGE)
About This Section
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Specialized Databases showing CLSTN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CLSTN1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CLSTN1 gene:
Search GeneIP for patents involving CLSTN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CLSTN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for CLSTN1 | | OriGene shRNA RFP for CLSTN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLSTN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLSTN1 | | | OriGene Protein Over-expression Lysate for CLSTN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLSTN1 | | OriGene 3'-UTR Clone for CLSTN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLSTN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLSTN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLSTN1 | | OriGene Custom Protein Services for CLSTN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLSTN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLSTN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLSTN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLSTN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLSTN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLSTN1 |
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 | | | CLSTN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLSTN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CLSTN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLSTN1 |
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