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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLSPN Gene

protein-coding GIFtS: 56
GCID: GC01M036185

claspin

(Previous name: claspin homolog (Xenopus laevis) )

Explore 9 diseases affiliated with
CLSPN via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Claspin¹
CLASPIN⁵
HClaspin¹
Claspin Homolog (Xenopus Laevis)¹
Claspin Homolog²

External Ids:	HGNC: 19715¹	Entrez Gene: 63967²	Ensembl: ENSG00000092853⁷	OMIM: 605434⁵	UniProtKB: Q9HAW4³

Export aliases for CLSPN gene to outside databases

Previous GC identifers: GC01M035241 GC01M035613 GC01M035614 GC01M035855 GC01M035958 GC01M034315

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLSPN:

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of

the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA

replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CLSPN_HUMAN, Q9HAW4

Function: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA

damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase

CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA

structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This

may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks

Gene Wiki entry for CLSPN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLSPN gene promoter:
SREBP-1c FOXO3 MyoD Pax-2 Pax-2a FOXO3b SREBP-1b Pax-2b SREBP-1a FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLSPN promoter sequence

Search SABiosciences Chromatin IP Primers for CLSPN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLSPN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3

CLSPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLSPN gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M036185: view genomic region (about GC identifiers)

Start:	36,185,819 bp from pter	End:	36,235,568 bp from pter
Size:	49,750 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLSPN_HUMAN, Q9HAW4 (See protein sequence)

Recommended Name: Claspin

Size: 1339 amino acids; 151094 Da

Subunit: Interacts (phosphorylation-dependent) with CHEK1; regulates CLSPN function in checkpoint for DNA damage and

replication. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation.

Interacts with BRCA1 and this interaction increases during checkpoint activation. Interacts with TIMELESS

Subcellular location: Nucleus

Sequence caution: Sequence=AAH38991.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH62215.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: A6NFL4 Q1RMC6 Q2KHM3 Q5VYG0 Q6P6H5 Q8IWI1

Alternative splicing: 3 isoforms: Q9HAW4-1 Q9HAW4-2 Q9HAW4-3

Explore the universe of human proteins at neXtProt for CLSPN: NX_Q9HAW4

Post-translational modifications:

Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage

checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding¹

Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the

proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated

by USP28 in G2 phase, preventing its degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HAW4

CLSPN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001177410.1 NP_071394.2

ENSEMBL proteins:

ENSP00000251195 ENSP00000312995 ENSP00000362317 ENSP00000428848

Reactome Protein details: Q9HAW4
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CLSPN

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--

CLSPN for ontologies About GeneDecksing

CLSPN Antibody Products:

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	Uscn ELISAs and CLIAs for CLSPN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLSPN for domains About GeneDecksing

2 InterPro domains/families:

IPR024146 Claspin/Claspin-like

IPR024147 Claspin

Graphical View of Domain Structure for InterPro Entry Q9HAW4

ProtoNet protein and cluster: Q9HAW4

UniProtKB/Swiss-Prot: CLSPN_HUMAN, Q9HAW4

Domain: The C-terminus of the protein contains 3 potential CHEK1-binding motifs (CKB motifs). Potential phosphorylation

sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1

Similarity: Belongs to the claspin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLSPN_HUMAN, Q9HAW4

Function: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA

damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase

CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA

structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This

may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks

Induction: Expression peaks at S/G2 phases of the cell cycle

miRNA Products:		OriGene 3'-UTR Clone: CLSPN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLSPN
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate CLSPN (see all 57):
		hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-765 hsa-miR-371-5p hsa-miR-424 hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: CLSPN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLSPN (see all 7) OriGene shRNA RFP: CLSPN OriGene siRNA: CLSPN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLSPN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CLSPN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLSPN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLSPN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLSPN (NM_022111)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLSPN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLSPN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLSPN
		Search LifeMap BioReagents cell lines for CLSPN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLSPN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	18662541
GO:0010997	anaphase-promoting complex binding	IPI	18662541

CLSPN for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CLSPN:

Decreased cell number and incr

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cellular proteins

1.00

Apoptotic execution phase

0.73

DNA damage ATM/ATR regulation of G1/S checkpoint

DNA damage ATM/ATR regulation of G1/S checkpoint

1.00

DNA damage_ATM/ATR regulation of G1/S checkpoint

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Ubiquitinated Orc1 is degraded by the proteasome

Cell Cycle Checkpoints

0.42

Apoptosis

0.31

DNA Damage

DNA Damage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CLSPN

DNA damage ATM/ATR regulation of G1/S checkpoint

2 Cell Signaling Technology (CST) Pathways for CLSPN

	Cell Cycle / Checkpoint Control
	DNA Damage

1 GeneGo (Thomson Reuters) Pathway for CLSPN

DNA damage ATM/ATR regulation of G1/S checkpoint

1 BioSystems Pathway for CLSPN

PLK1 signaling events

5/7 Reactome Pathways for CLSPN (see all 7)

	Activation of ATR in response to replication stress
	Apoptotic execution phase
	Apoptotic cleavage of cellular proteins
	Cell Cycle
	G2/M Checkpoints

CLSPN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CLSPN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for CLSPN (Q9HAW4^{1, 2, 3} ENSP00000312995⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAD9A	Q99638²^,³, ENSP00000311360⁴	MINT-7897445 I2D: score=3 STRING: ENSP00000311360
FZR1	Q9UM11¹^,³, ENSP00000378529⁴	EBI-1369377,EBI-2558941 I2D: score=1 STRING: ENSP00000378529
CDK9	P50750²^,³, ENSP00000362361⁴	MINT-8058048 MINT-8058001 MINT-8058040 I2D: score=1 STRING: ENSP00000362361
ATR	Q13535²^,³, ENSP00000343741⁴	MINT-8058048 MINT-8058001 I2D: score=2 STRING: ENSP00000343741
CHEK1	O14757¹^,³, ENSP00000278916⁴	EBI-1369377,EBI-974488 I2D: score=3 STRING: ENSP00000278916

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000077	DNA damage checkpoint	IMP	16963448
GO:0006260	DNA replication	TAS	--
GO:0006281	DNA repair	IEA	--
GO:0006915	apoptotic process	TAS	--

CLSPN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLSPN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLSPN
3 Novoseek chemical compound relationships for CLSPN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyurea	69.3	6	12766152 (1), 16501606 (1), 19464357 (1), 16828751 (1) (see all 5)
aphidicolin	55	4	19760606 (2), 12897072 (1), 16828751 (1)
1,25 dihydroxy vitamin d3	29.8	1	17638866 (1)

Search CenterWatch for drugs/clinical trials and news about CLSPN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLSPN gene (2 alternative transcripts):

NM_001190481.1 NM_022111.3

Unigene Cluster for CLSPN:

Claspin

Hs.175613 [show with all ESTs]

Unigene Representative Sequence: NM_022111

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251195 ENST00000466308 ENST00000318121(uc001bzi.3) ENST00000373220(uc009vux.3)

ENST00000520551 ENST00000517467

miRNA Products:		OriGene 3'-UTR Clone: CLSPN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLSPN
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate CLSPN (see all 57):
		hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-765 hsa-miR-371-5p hsa-miR-424 hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: CLSPN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLSPN (see all 7) OriGene shRNA RFP: CLSPN OriGene siRNA: CLSPN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLSPN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLSPN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLSPN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CLSPN (NM_022111)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLSPN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLSPN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLSPN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLSPN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLSPN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLSPN

Additional cDNA sequence:

AK308193.1 AY605064.1 BC018670.1 BC038991.2 BC062215.1 BC113116.1 BC115023.1 BC115024.1

BC115025.1 BC115026.1 BC115027.1 BC137279.1 BC140789.1

7 DOTS entries:

DT.100746945 DT.100746944 DT.70103329 DT.75120338 DT.121349907 DT.95189702 DT.97797232

24/40 AceView cDNA sequences (see all 40):

AA857451 AA857804 BM461846 BC018670 BM827145 BP364067 AI635556 AI569660

BU193221 BU181027 BM799186 BG469801 BM828080 BC038991 BU662956 BC062215

BF968339 BM810946 BM676972 BE882484 BQ227287 BP364700 AL699150 BM720876

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLSPN (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19	^	20	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	21	^	22	^	23	^	24	^	25	^	26a	·	26b
SP1:
SP2:
SP3:					-
SP4:
SP5:

ECgene alternative splicing isoforms for CLSPN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLSPN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCACTGATG

About this image
See CLSPN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLSPN

SOURCE GeneReport for Unigene cluster: Hs.175613

SABiosciences Custom PCR Arrays for CLSPN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLSPN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLSPN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLSPN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLSPN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CLSPN gene from 7/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Clspn^{1 , 5}	claspin homolog (Xenopus laevis)⁵ claspin¹	81.8(n)¹ 77.5(a)¹		4 (60.90 cM)⁵ 269582¹ NM_175554.4¹ NP_780763.3¹ 126556935⁵
chicken (Gallus gallus)	Aves	CLSPN¹	claspin	64.86(n) 59.29(a)		428223 NM_001199194.1 NP_001186123.1
lizard (Anolis carolinensis)	Reptilia	-- CLSPN⁶	--	66(a) 44(a)	1 ↔ 1 possible ortholog	GL343843.1(9795-14160) AAWZ02038841(842-9886)
African clawed frog (Xenopus laevis)	Amphibia	LOC398192²	Claspin	75.49(n)		AF297867.2
zebrafish (Danio rerio)	Actinopterygii	LOC564151¹	claspin-like	55.54(n) 49.77(a)		564151 XM_002665601.2 XP_002665647.2
fruit fly (Drosophila melanogaster)	Insecta	CG32251¹	CG32251	41.03(n) 24.72(a)		326205 NM_168080.1 NP_728981.1
worm (Caenorhabditis elegans)	Secernentea	F25H5.5¹	Protein F25H5.5	42.68(n) 27.85(a)		172742 NM_060055.4 NP_492456.2

ENSEMBL Gene Tree for CLSPN (if available)
TreeFam Gene Tree for CLSPN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66781105^1,2	C	--	34322212(+)	`TTTTT-/TTTTTT`	1	--	int¹		1		NA	2
rs114192896^1,2	F,	--	36197224(+)	`AGAAAT/CTGTGG`	2	--	ds500¹		1		WA	118
rs75182628^1,2	F,	--	36197242(+)	`GACCAG/AGGGGC`	2	--	ds500¹		1		WA	118
rs6425954^1,2	C,F,A,H,	--	36197297(+)	`GGAAGT/CAGAAA`	2	--	ds500¹		22		NS EA NA WA CSA	2350
rs147027963^1,2		--	36197319(+)	`GGAAAC/TTGTCT`	2	--	ds500¹		0	--	--	--	--
rs79062711^1,2	F,	--	36197322(+)	`AATTGT/CCTGAT`	2	--	ds500¹		1		EA	120
rs185400692^1,2		--	36197420(+)	`AAATAC/TAGGAG`	2	--	ds500¹		0	--	--	--	--
rs138307400^1,2		--	36197802(+)	`GGTAGA/GAGATA`	2	--	ut3¹		0	--	--	--	--
rs115579550^1,2	C,	--	36197862(+)	`CTCCCA/GGAAAT`	2	--	ut3¹		0	--	--	--	--
rs190645289^1,2		--	36197940(+)	`TAGGAA/GATAAA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CLSPN (36185819 - 36235568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLSPN: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLSPN for disorders           About GeneDecksing

OMIM gene information: 605434    OMIM disorders: --

9 diseases for CLSPN:    About MalaCards

ataxia telangiectasia fanconi's anemia ataxia anemia

breast carcinoma prostate cancer breast cancer prostatitis

carcinoma

3 Novoseek disease relationships for CLSPN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	61.5	3	19124652 (1), 16963448 (1), 15096610 (1)
cancer	10.8	15	19737971 (3), 17152083 (3), 18077083 (1)
tumors	0	7	15096610 (2), 19737971 (1), 17638866 (1), 18077083 (1)

Human Genome Epidemiology (HuGE) Navigator: CLSPN (1 document)

Export disorders for CLSPN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLSPN gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with CLSPN)

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Human claspin is required for replication checkpoint control. (PubMed id 12766152)^{1, 2, 3, 9} Chini C.C. and Chen J. (2003)
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. (PubMed id 11090622)^{1, 2, 3, 9} Kumagai A. and Dunphy W.G. (2000)
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. (PubMed id 16963448)^{1, 2, 9} Chini C.C. and Chen J. (2006)
Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation. (PubMed id 15096610)^{1, 2, 9} Lin S.-Y.... Elledge S.J. (2004)
DNA-dependent phosphorylation of Chk1 and claspin in a human cell- free system. (PubMed id 15707391)^{1, 2, 9} Clarke C.A.L. and Clarke P.R. (2005)
ATR, claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. (PubMed id 15190204)^{1, 2, 9} Sorensen C.S.... Bartek J. (2004)
Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. (PubMed id 15226314)^{1, 2, 9} Sar F.... Sancar A. (2004)
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. (PubMed id 16901786)^{1, 2, 9} Zhang D....Elledge S.J. (2006)
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)^{1, 2} Bassermann F....Pagano M. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 63967	HGNC: 19715	AceView: CLSPN.1	Ensembl:ENSG00000092853	euGenes: HUgn63967
ECgene: CLSPN	H-InvDB: CLSPN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLSPN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CLSPN	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CLSPN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CLSPN gene:
Search GeneIP for patents involving CLSPN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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