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Aliases for CLSPN Gene

Aliases for CLSPN Gene

  • Claspin 2 3
  • HClaspin 3 4
  • Claspin Homolog (Xenopus Laevis) 2
  • Claspin Homolog 3

External Ids for CLSPN Gene

Previous GeneCards Identifiers for CLSPN Gene

  • GC01M035241
  • GC01M035613
  • GC01M035614
  • GC01M035855
  • GC01M035958
  • GC01M036185
  • GC01M034315

Summaries for CLSPN Gene

Entrez Gene Summary for CLSPN Gene

  • The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CLSPN Gene

CLSPN (Claspin) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and DNA Damage. GO annotations related to this gene include anaphase-promoting complex binding.

UniProtKB/Swiss-Prot for CLSPN Gene

  • Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Gene Wiki entry for CLSPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLSPN Gene

Genomics for CLSPN Gene

Regulatory Elements for CLSPN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLSPN Gene

Chromosome:
1
Start:
35,720,218 bp from pter
End:
35,769,997 bp from pter
Size:
49,780 bases
Orientation:
Minus strand

Genomic View for CLSPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLSPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLSPN Gene

Proteins for CLSPN Gene

  • Protein details for CLSPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW4-CLSPN_HUMAN
    Recommended name:
    Claspin
    Protein Accession:
    Q9HAW4
    Secondary Accessions:
    • A6NFL4
    • Q1RMC6
    • Q2KHM3
    • Q5VYG0
    • Q6P6H5
    • Q8IWI1

    Protein attributes for CLSPN Gene

    Size:
    1339 amino acids
    Molecular mass:
    151094 Da
    Quaternary structure:
    • Interacts (phosphorylation-dependent) with CHEK1; regulates CLSPN function in checkpoint for DNA damage and replication. Interacts with ATR and RAD9A and these interactions are slightly reduced during checkpoint activation. Interacts with BRCA1 and this interaction increases during checkpoint activation. Interacts with TIMELESS.
    SequenceCaution:
    • Sequence=AAH38991.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62215.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for CLSPN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLSPN Gene

Proteomics data for CLSPN Gene at MOPED

Post-translational modifications for CLSPN Gene

  • Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding.
  • Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLSPN Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CLSPN (claspin)

No data available for DME Specific Peptides for CLSPN Gene

Domains & Families for CLSPN Gene

Protein Domains for CLSPN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLSPN Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAW4

UniProtKB/Swiss-Prot:

CLSPN_HUMAN :
  • The C-terminus of the protein contains 3 potential CHEK1-binding motifs (CKB motifs). Potential phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1
  • Belongs to the claspin family.
Domain:
  • The C-terminus of the protein contains 3 potential CHEK1-binding motifs (CKB motifs). Potential phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1
Family:
  • Belongs to the claspin family.
genes like me logo Genes that share domains with CLSPN: view

No data available for Gene Families for CLSPN Gene

Function for CLSPN Gene

Molecular function for CLSPN Gene

UniProtKB/Swiss-Prot Function:
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
UniProtKB/Swiss-Prot Induction:
Expression peaks at S/G2 phases of the cell cycle.

Gene Ontology (GO) - Molecular Function for CLSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16885022
GO:0010997 anaphase-promoting complex binding IPI 18662541
genes like me logo Genes that share ontologies with CLSPN: view
genes like me logo Genes that share phenotypes with CLSPN: view

Animal Model Products

miRNA for CLSPN Gene

miRTarBase miRNAs that target CLSPN

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLSPN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CLSPN Gene

Localization for CLSPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLSPN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLSPN Gene COMPARTMENTS Subcellular localization image for CLSPN gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for CLSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CLSPN: view

Pathways & Interactions for CLSPN Gene

genes like me logo Genes that share pathways with CLSPN: view

Pathways by source for CLSPN Gene

1 Cell Signaling Technology pathway for CLSPN Gene
1 BioSystems pathway for CLSPN Gene

SIGNOR curated interactions for CLSPN Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CLSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 16963448
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair TAS --
genes like me logo Genes that share ontologies with CLSPN: view

Drugs & Compounds for CLSPN Gene

(1) Drugs for CLSPN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxyurea Approved Pharma 181

(2) Additional Compounds for CLSPN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
Aphidicolin
genes like me logo Genes that share compounds with CLSPN: view

Transcripts for CLSPN Gene

Unigene Clusters for CLSPN Gene

Claspin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLSPN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLSPN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLSPN Gene

GeneLoc Exon Structure for
CLSPN
ECgene alternative splicing isoforms for
CLSPN

Expression for CLSPN Gene

mRNA expression in normal human tissues for CLSPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLSPN Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for CLSPN Gene

This gene is overexpressed in Plasma (30.5), Adrenal (17.1), and Lung (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLSPN Gene



SOURCE GeneReport for Unigene cluster for CLSPN Gene Hs.175613

genes like me logo Genes that share expression patterns with CLSPN: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CLSPN Gene

Orthologs for CLSPN Gene

This gene was present in the common ancestor of animals.

Orthologs for CLSPN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLSPN 35
  • 86.89 (n)
  • 83.75 (a)
CLSPN 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clspn 35
  • 81.18 (n)
  • 76.5 (a)
Clspn 16
Clspn 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLSPN 35
  • 98.18 (n)
  • 97.68 (a)
CLSPN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clspn 35
  • 80.48 (n)
  • 76.85 (a)
dog
(Canis familiaris)
Mammalia CLSPN 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLSPN 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLSPN 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLSPN 35
  • 65.15 (n)
  • 59.73 (a)
CLSPN 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLSPN 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clspn 35
  • 59.29 (n)
  • 53.1 (a)
Str.6391 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398192 35
zebrafish
(Danio rerio)
Actinopterygii CLSPN (1 of 2) 36
  • 29 (a)
OneToMany
CLSPN (2 of 2) 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32251 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToOne
Species with no ortholog for CLSPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLSPN Gene

ENSEMBL:
Gene Tree for CLSPN (if available)
TreeFam:
Gene Tree for CLSPN (if available)

Paralogs for CLSPN Gene

No data available for Paralogs for CLSPN Gene

Variants for CLSPN Gene

Sequence variations from dbSNP and Humsavar for CLSPN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs516992 -- 35,748,111(-) AATGA(A/C)TGACA intron-variant
rs535638 -- 35,751,234(-) ATTAC(A/G)TTGTT intron-variant
rs577483 -- 35,739,565(+) CAACA(A/G)TGAAT intron-variant
rs594707 -- 35,770,711(-) aaaaa(C/T)acaaa upstream-variant-2KB
rs609070 -- 35,734,789(-) TTTTA(C/T)TGGGA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLSPN Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834680 CNV Gain 17160897

Variation tolerance for CLSPN Gene

Residual Variation Intolerance Score: 90.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.86; 97.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLSPN Gene

HapMap Linkage Disequilibrium report
CLSPN
Human Gene Mutation Database (HGMD)
CLSPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLSPN Gene

Disorders for CLSPN Gene

Relevant External Links for CLSPN

Genetic Association Database (GAD)
CLSPN
Human Genome Epidemiology (HuGE) Navigator
CLSPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLSPN
genes like me logo Genes that share disorders with CLSPN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLSPN Gene

Publications for CLSPN Gene

  1. Human claspin is required for replication checkpoint control. (PMID: 12766152) Chini C.C.S. … Chen J. (J. Biol. Chem. 2003) 2 23 67
  2. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. (PMID: 11090622) Kumagai A. … Dunphy W.G. (Mol. Cell 2000) 2 23 67
  3. The position of the amino group on the benzene ring is critical for mesalamine's improvement of replication fidelity. (PMID: 19821510) Campregher C. … Gasche C. (Inflamm. Bowel Dis. 2010) 23 67
  4. Drf1-dependent kinase interacts with Claspin through a conserved protein motif. (PMID: 20190277) Gold D.A. … Dunphy W.G. (J. Biol. Chem. 2010) 23 67
  5. Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. (PMID: 20029092) Liu Y. … Modrich P. (J. Biol. Chem. 2010) 23 67

Products for CLSPN Gene

Sources for CLSPN Gene

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