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Aliases for CLRN3 Gene

Aliases for CLRN3 Gene

  • Clarin 3 2 3
  • Transmembrane Protein 12 2 3 4
  • Usher Syndrome Type-3A-Like Protein 1 3 4
  • USH3AL1 3 4
  • TMEM12 3 4
  • Clarin-3 3

External Ids for CLRN3 Gene

Previous HGNC Symbols for CLRN3 Gene

  • TMEM12

Previous GeneCards Identifiers for CLRN3 Gene

  • GC10M129568
  • GC10M129676
  • GC10M123250

Summaries for CLRN3 Gene

GeneCards Summary for CLRN3 Gene

CLRN3 (Clarin 3) is a Protein Coding gene. Diseases associated with CLRN3 include usher syndrome. An important paralog of this gene is CLRN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLRN3 Gene

Genomics for CLRN3 Gene

Regulatory Elements for CLRN3 Gene

Genomic Location for CLRN3 Gene

Start:
127,877,841 bp from pter
End:
127,892,947 bp from pter
Size:
15,107 bases
Orientation:
Minus strand

Genomic View for CLRN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLRN3 Gene

Proteins for CLRN3 Gene

  • Protein details for CLRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCR9-CLRN3_HUMAN
    Recommended name:
    Clarin-3
    Protein Accession:
    Q8NCR9
    Secondary Accessions:
    • Q6MZX8

    Protein attributes for CLRN3 Gene

    Size:
    226 amino acids
    Molecular mass:
    25321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE45899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLRN3 Gene

Proteomics data for CLRN3 Gene at MOPED

Post-translational modifications for CLRN3 Gene

  • Glycosylation at Asn83
  • Modification sites at PhosphoSitePlus

Other Protein References for CLRN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLRN3 Gene

Domains for CLRN3 Gene

Protein Domains for CLRN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLRN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCR9

UniProtKB/Swiss-Prot:

CLRN3_HUMAN :
  • Q8NCR9
Family:
  • Belongs to the clarin family.
genes like me logo Genes that share domains with CLRN3: view

No data available for Gene Families for CLRN3 Gene

Function for CLRN3 Gene

genes like me logo Genes that share phenotypes with CLRN3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLRN3 Gene

Localization for CLRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLRN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLRN3 Gene COMPARTMENTS Subcellular localization image for CLRN3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CLRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CLRN3: view

Pathways for CLRN3 Gene

SuperPathways for CLRN3 Gene

No Data Available

Interacting Proteins for CLRN3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357660%0d%0a9606.ENSP00000403397%0d%0a
Selected Interacting proteins: ENSP00000357660 for CLRN3 Gene via STRING

Symbol External ID(s) Details
ZDHHC17

Gene Ontology (GO) - Biological Process for CLRN3 Gene

None

No data available for Pathways by source for CLRN3 Gene

Transcripts for CLRN3 Gene

mRNA/cDNA for CLRN3 Gene

(47) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLRN3 Gene

Clarin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLRN3 Gene

No ASD Table

Relevant External Links for CLRN3 Gene

GeneLoc Exon Structure for
CLRN3
ECgene alternative splicing isoforms for
CLRN3

Expression for CLRN3 Gene

mRNA expression in normal human tissues for CLRN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLRN3 Gene

This gene is overexpressed in Colon - Transverse (20.9), Small Intestine - Terminal Ileum (13.4), Liver (9.4), and Kidney - Cortex (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLRN3 Gene

SOURCE GeneReport for Unigene cluster for CLRN3 Gene Hs.242014

genes like me logo Genes that share expressions with CLRN3: view

No data available for mRNA Expression by UniProt/SwissProt for CLRN3 Gene

Orthologs for CLRN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLRN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLRN3 35
  • 98.97 (n)
  • 97.79 (a)
CLRN3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLRN3 35
  • 79.06 (n)
  • 74.78 (a)
CLRN3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLRN3 35
  • 80.53 (n)
  • 76.11 (a)
CLRN3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clrn3 35
  • 76.4 (n)
  • 73.01 (a)
Clrn3 16
Clrn3 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLRN3 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clrn3 35
  • 76.84 (n)
  • 75.66 (a)
chicken
(Gallus gallus)
Aves CLRN3 35
  • 56.64 (n)
  • 43.36 (a)
CLRN3 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLRN3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clrn3 35
  • 52.44 (n)
  • 45.33 (a)
zebrafish
(Danio rerio)
Actinopterygii CLRN3 36
  • 30 (a)
OneToOne
LOC100000502 35
  • 45.48 (n)
  • 32.44 (a)
Species with no ortholog for CLRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLRN3 Gene

ENSEMBL:
Gene Tree for CLRN3 (if available)
TreeFam:
Gene Tree for CLRN3 (if available)

Paralogs for CLRN3 Gene

Paralogs for CLRN3 Gene

genes like me logo Genes that share paralogs with CLRN3: view

Variants for CLRN3 Gene

Sequence variations from dbSNP and Humsavar for CLRN3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs748555 -- 127,894,654(+) AACTG(G/T)CAAGA upstream-variant-2KB
rs1410063 -- 127,881,386(+) TGCGG(A/G)GGAGC intron-variant
rs1887462 -- 127,883,042(+) GCTCC(A/G)TCCTC intron-variant
rs2148895 -- 127,894,029(-) AGCTA(A/G)TTCCA upstream-variant-2KB
rs2296785 -- 127,877,905(+) CGTTA(C/T)GCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLRN3 Gene

Variant ID Type Subtype PubMed ID
nsv832020 CNV Gain 17160897
nsv896097 CNV Gain 21882294

Relevant External Links for CLRN3 Gene

HapMap Linkage Disequilibrium report
CLRN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLRN3 Gene

Disorders for CLRN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CLRN3 Gene including...

Search for CLRN3 Gene in MalaCards »

Relevant External Links for CLRN3

Genetic Association Database (GAD)
CLRN3
Human Genome Epidemiology (HuGE) Navigator
CLRN3
genes like me logo Genes that share disorders with CLRN3: view

No data available for UniProtKB/Swiss-Prot for CLRN3 Gene

Publications for CLRN3 Gene

  1. USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses. (PMID: 12080385) Adato A. … Lancet D. (Eur. J. Hum. Genet. 2002) 2 3
  2. Usher syndrome type III: revised genomic structure of the USH3 gene and identification of novel mutations. (PMID: 12145752) Fields R.R. … Sumegi J. (Am. J. Hum. Genet. 2002) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CLRN3 Gene

Sources for CLRN3 Gene

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