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CLPX Gene

protein-coding   GIFtS: 55
GCID: GC15M065440

Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit

(Previous names: ClpX (caseinolytic protease X, E. coli) homolog, ClpX caseinolytic...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit1 2     ATP-Dependent Clp Protease ATP-Binding Subunit ClpX-Like, Mitochondrial2
ClpX (Caseinolytic Protease X, E. Coli) Homolog1     ClpX Caseinolytic Peptidase X Homolog2
ClpX Caseinolytic Peptidase X Homolog (E. Coli)1     ClpX Caseinolytic Protease X Homolog2
ClpX Caseinolytic Protease X Homolog (E. Coli)1     Energy-Dependent Regulator Of Proteolysis2

External Ids:    HGNC: 20881   Entrez Gene: 108452   Ensembl: ENSG000001668557   OMIM: 6156115   UniProtKB: O760313   

Export aliases for CLPX gene to outside databases

Previous GC identifers: GC15M061220 GC15M058542 GC15M063019 GC15M063158 GC15M063229 GC15M042267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLPX Gene:
CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) is a protein-coding gene. GO annotations related to this gene include peptidase activator activity and ATPase activity.

UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
Function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates.
Can perform chaperone functions in the absence of clpP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLPX gene promoter:
         HOXA9B   HOXA9   MyoD   STAT5A   Meis-1b   C/EBPalpha   PPAR-alpha   IRF-2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPX promoter sequence
   Search Chromatin IP Primers for CLPX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

CLPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPX gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065440:  view genomic region     (about GC identifiers)

Start:
65,440,557 bp from pter      End:
65,477,680 bp from pter
Size:
37,124 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031 (See protein sequence)
Recommended Name: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor  
Size: 633 amino acids; 69224 Da
Subunit: Heterodimer of clpP and clpX (By similarity)
Secondary accessions: A1L428 A8K8F1 B9EGI8 Q9H4D9

Explore the universe of human proteins at neXtProt for CLPX: NX_O76031

Explore proteomics data for CLPX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLPX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006651.2  
    ENSEMBL proteins: 
     ENSP00000300107   ENSP00000453461   ENSP00000452611  

    CLPX Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CLPX

     
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    Search eBioscience for ELISAs for CLPX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR019489 Clp_ATPase_C
     IPR013093 ATPase_AAA-2
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR004487 Clp_protease_ATP-bd_su_ClpX

    Graphical View of Domain Structure for InterPro Entry O76031

    ProtoNet protein and cluster: O76031

    UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
    Similarity: Belongs to the ClpX chaperone family


    Find genes that share domains with CLPX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLPX_HUMAN, O76031
    Function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates.
    Can perform chaperone functions in the absence of clpP (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004176contributes to ATP-dependent peptidase activity IDA16115876
    GO:0005515protein binding IPI11923310
    GO:0005524ATP binding ISS--
    GO:0008134transcription factor binding ----
         
    Find genes that share ontologies with CLPX           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLPX:
     Decreased circadian period len  Synthetic lethal with Ras  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLPX
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLPX

    miRNA
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    miRTarBase miRNAs that target CLPX:
    hsa-let-7b-5p (MIRT032371)

    Block miRNA regulation of human, mouse, rat CLPX using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CLPX:
    hsa-miR-591 hsa-miR-3674 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCLPX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLPX

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    GenScript: all cDNA clones in your preferred vector: CLPX (NM_006660)
    Sino Biological Human cDNA Clone for CLPX
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPX

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLPX_HUMAN, O76031: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005739mitochondrion IDA11003706
    GO:0005743mitochondrial inner membrane ISS--
    GO:0005759mitochondrial matrix IDA10525407
    GO:0009368endopeptidase Clp complex IDA11923310

    Find genes that share ontologies with CLPX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLPX
    Interactions:

        GeneGlobe Interaction Network for CLPX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLPX (O760312, 3 ENSP000003001074) via UniProtKB, MINT, STRING, and/or I2D (see all 348)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLDIP2Q9Y2S72, 3MINT-8079030 I2D: score=2 
    LONP1P367762, 3MINT-8079030 I2D: score=1 
    RARS2Q5T1602, 3MINT-8079030 I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006457protein folding IEA--
    GO:0010952positive regulation of peptidase activity IDA11923310
    GO:0051603proteolysis involved in cellular protein catabolic process IDA16115876

    Find genes that share ontologies with CLPX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLPX

    1 Novoseek inferred chemical compound relationship for CLPX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 33.1 6 19549599 (1), 19892734 (1), 12937164 (1), 15064753 (1)



    Find genes that share compounds with CLPX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLPX gene: 
    NM_006660.3  

    Unigene Cluster for CLPX:

    ClpX caseinolytic peptidase X homolog (E. coli)
    Hs.113823  [show with all ESTs]
    Unigene Representative Sequence: AL136922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300107(uc002aom.3 uc010uiu.2) ENST00000559152 ENST00000560166
    ENST00000558958(uc010bhg.1) ENST00000558103 ENST00000559218
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLPX using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CLPX:
    hsa-miR-591 hsa-miR-3674 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCLPX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLPX
    Predesigned siRNA for gene silencing in human, mouse, rat CLPX
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLPX (NM_006660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPX
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLPX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLPX
      QuantiTect SYBR Green Assays in human, mouse, rat CLPX
      QuantiFast Probe-based Assays in human, mouse, rat CLPX

    Additional mRNA sequence: 

    AJ006267.3 AK292316.1 AK308133.1 AK310614.1 AL136922.1 BC130373.1 BC136487.1 BC144166.1 

    6 DOTS entries:

    DT.414576  DT.409982  DT.40230324  DT.102829467  DT.92418842  DT.99953126 

    Selected AceView cDNA sequences (see all 146):

    NM_006660 CB852812 BF432309 AA292065 AJ006267 BG503457 BE502812 AI962833 
    BU618822 CA448123 CN482288 AA515776 BX486198 AA636038 AV651185 BG502968 
    AU279705 AI223970 AW020766 AI818123 CN483221 BF222305 AI499357 AA257016 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLPX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATAATTG
    CLPX Expression
    About this image

    CLPX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLPX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113823

    UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
    Tissue specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain,
    placenta, lung, kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLPX gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clpx1 , 5 caseinolytic peptidase X (E.coli)1, 5 90.42(n)1
    96.05(a)1
      9 (35.22 cM)5
    2701661  NM_011802.31  NP_035932.21 
     652942605 
    chicken
    (Gallus gallus)
    Aves CLPX1 ClpX caseinolytic peptidase X homolog (E. coli) 82.83(n)
    92.37(a)
      415527  NM_001030552.1  NP_001025723.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLPX6
    caseinolytic mitochondrial matrix peptidase chaper...
    91(a)
    1 ↔ 1
    GL343392.1(303001-327196)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.332342 Xenopus laevis transcribed sequence with moderate similarity more 75(n)    48013092 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb93b072 Transcribed sequence with moderate similarity to protein more 76.74(n)    57044018 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45381 , 3 endopeptidase Clp3
    CG45381
    60(a)3
    59.21(n)1
    66.46(a)1
      92B63
    423691  NM_142586.11  NP_650843.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D2030.21 , 3 ATP-dependent CLP protease (CLPX) like3
    D2030.21
    42(a)
    (best of 2)3
    53.37(n)1
    46.28(a)1
      I(7582340-7586399)3
    1725111  NM_001025905.31  NP_001021076.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCX1(YBR227C)4
    MCX11
    Mitochondrial matrix protein; putative ATP-binding more4
    MCX11
    51.8(n)1
    43.19(a)1
      2(675134-673572)4
    8525281, 4  NP_009786.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os.214062 Transcribed sequence with moderate similarity to protein more 75.97(n)    CB617934.1 


    ENSEMBL Gene Tree for CLPX (if available)
    TreeFam Gene Tree for CLPX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLPX gene
    1 SIMAP similar gene for CLPX using alignment to 3 protein entries:     CLPX_HUMAN (see all proteins):
    DKFZp586J151

    Find genes that share paralogs with CLPX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CLPX
    PGOHUM00000240694


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLPX (see all 720)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908879191,2
    --65442434(+) ACTTTA/GTCGCC 1 -- ds50010--------
    rs1491464711,2
    C--65442461(+) GGCACA/GACCTC 1 -- ds50010--------
    rs29466671,2
    C,A--65442479(+) TGTAAC/ACTCTG 1 -- ds50018Minor allele frequency- A:0.22NA WA CSA 133
    rs129099811,2
    C,F--65442523(+) CTCCCA/GAGTAG 1 -- ds50015Minor allele frequency- G:0.30NA CSA 10
    rs1840372641,2
    --65442648(+) CGCCTC/TGGCCT 1 -- ds50010--------
    rs1115149451,2
    F--65442676(+) ACAGGC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1929943871,2
    C--65442705(+) CTGGTC/TCAATT 1 -- ds50010--------
    rs1149313531,2
    C,F--65442984(+) CTTCCG/ATAAAA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs734750431,2
    C,F--65443063(+) TATCCA/CAGATA 1 -- ut312Minor allele frequency- C:0.04WA 120
    rs1388434371,2
    --65443077(+) CCAATA/GCCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLPX (65440557 - 65477680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLPX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670622CNV Deletion23128226
    esv2508866CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLPX
    DNA2.0 Custom Variant and Variant Library Synthesis for CLPX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615611    OMIM disorders: --


    Find genes that share disorders with CLPX           About GenesLikeMe

    Genetic Association Database (GAD): CLPX
    Human Genome Epidemiology (HuGE) Navigator: CLPX (1 document)

    Export disorders for CLPX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLPX gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CLPX)
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    1. Human and mouse mitochondrial orthologs of bacterial ClpX. (PubMed id 11003706)1, 2, 9 Corydon T.J.... Bross P. (Mamm. Genome 2000)
    2. Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX. (PubMed id 22841477)1, 3 Kasashima K....Endo H. (Exp. Cell Res. 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    6. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
    7. Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. (PubMed id 22710082)1 Lowth B.R....Dougan D.A. (J. Struct. Biol. 2012)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10845 HGNC: 2088 AceView: CLPX Ensembl:ENSG00000166855 euGenes: HUgn10845
    ECgene: CLPX H-InvDB: CLPX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLPX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLPX gene:
    Search GeneIP for patents involving CLPX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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