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Aliases for CLPX Gene

Aliases for CLPX Gene

  • Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit 2 3
  • ClpX (Caseinolytic Protease X, E. Coli) Homolog 2
  • ClpX Caseinolytic Peptidase X Homolog (E. Coli) 2
  • ClpX Caseinolytic Protease X Homolog (E. Coli) 2

External Ids for CLPX Gene

Summaries for CLPX Gene

GeneCards Summary for CLPX Gene

CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and peptidase activator activity.

UniProtKB/Swiss-Prot for CLPX Gene

  • ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPX Gene

Genomics for CLPX Gene

Genomic Location for CLPX Gene

Start:
65,148,219 bp from pter
End:
65,185,404 bp from pter
Size:
37,186 bases
Orientation:
Minus strand

Genomic View for CLPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPX Gene

Regulatory Elements for CLPX Gene

Proteins for CLPX Gene

  • Protein details for CLPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76031-CLPX_HUMAN
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Protein Accession:
    O76031
    Secondary Accessions:
    • A1L428
    • A8K8F1
    • B9EGI8
    • Q9H4D9

    Protein attributes for CLPX Gene

    Size:
    633 amino acids
    Molecular mass:
    69224 Da
    Quaternary structure:
    • Homohexamer that forms a ring structure; this hexamerization requires ATP binding. Component of the Clp complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex. Interacts with TFAM.

neXtProt entry for CLPX Gene

Proteomics data for CLPX Gene at MOPED

Post-translational modifications for CLPX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPX Gene

Domains for CLPX Gene

Gene Families for CLPX Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for CLPX Gene

UniProtKB/Swiss-Prot:

CLPX_HUMAN
Family:
  • Belongs to the ClpX chaperone family.:
    • O76031
genes like me logo Genes that share domains with CLPX: view

Function for CLPX Gene

Molecular function for CLPX Gene

UniProtKB/Swiss-Prot Function: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure.

Gene Ontology (GO) - Molecular Function for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004176 contributes_to ATP-dependent peptidase activity IDA 16115876
GO:0005515 protein binding IPI 11923310
GO:0005524 ATP binding ISS --
GO:0008134 transcription factor binding --
GO:0016504 peptidase activator activity IDA 11923310
genes like me logo Genes that share ontologies with CLPX: view

Phenotypes for CLPX Gene

genes like me logo Genes that share phenotypes with CLPX: view

miRNA for CLPX Gene

miRTarBase miRNAs that target CLPX

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLPX Gene

Localization for CLPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPX Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLPX Gene COMPARTMENTS Subcellular localization image for CLPX gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane ISS --
GO:0005759 mitochondrial matrix IDA 10525407
genes like me logo Genes that share ontologies with CLPX: view

Pathways for CLPX Gene

SuperPathways for CLPX Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006457 protein folding IEA --
GO:0010952 positive regulation of peptidase activity IDA 11923310
GO:0051603 proteolysis involved in cellular protein catabolic process IDA 16115876
genes like me logo Genes that share ontologies with CLPX: view

No data available for Pathways by source for CLPX Gene

Compounds for CLPX Gene

(1) Novoseek inferred chemical compound relationships for CLPX Gene

Compound -log(P) Hits PubMed IDs
atp 33.1 4
genes like me logo Genes that share compounds with CLPX: view

Transcripts for CLPX Gene

Unigene Clusters for CLPX Gene

ClpX caseinolytic peptidase X homolog (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLPX Gene

No ASD Table

Relevant External Links for CLPX Gene

GeneLoc Exon Structure for
CLPX
ECgene alternative splicing isoforms for
CLPX

Expression for CLPX Gene

mRNA expression in normal human tissues for CLPX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLPX Gene

SOURCE GeneReport for Unigene cluster for CLPX Gene Hs.113823

mRNA Expression by UniProt/SwissProt for CLPX Gene

O76031-CLPX_HUMAN
Tissue specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
genes like me logo Genes that share expressions with CLPX: view

Orthologs for CLPX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPX 36
  • 99.79 (n)
  • 99.53 (a)
CLPX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLPX 36
  • 95 (n)
  • 98.35 (a)
CLPX 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLPX 36
  • 95.16 (n)
  • 98.42 (a)
CLPX 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clpx 36
  • 90.42 (n)
  • 96.05 (a)
Clpx 16
Clpx 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLPX 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLPX 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clpx 36
  • 91.15 (n)
  • 96.21 (a)
chicken
(Gallus gallus)
Aves CLPX 36
  • 82.83 (n)
  • 92.37 (a)
CLPX 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLPX 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33234 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6113 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1425 36
zebrafish
(Danio rerio)
Actinopterygii CLPX (3 of 3) 37
  • 71 (a)
OneToMany
clpxa 36
  • 71 (n)
  • 84.35 (a)
clpxa 37
  • 89 (a)
OneToMany
clpxb 37
  • 80 (a)
OneToMany
wufb93b07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002996 36
  • 60.55 (n)
  • 69.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4538 36
  • 59.21 (n)
  • 66.46 (a)
CG4538 37
  • 50 (a)
OneToOne
CG4538 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea D2030.2 36
  • 53.37 (n)
  • 46.28 (a)
D2030.2 37
  • 41 (a)
OneToMany
K07A3.3 37
  • 39 (a)
OneToMany
D2030.2 38
  • 42 (a)
K07A3.3 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCX1 36
  • 51.8 (n)
  • 43.19 (a)
MCX1 37
  • 37 (a)
OneToOne
MCX1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09691g 36
  • 51.93 (n)
  • 47.04 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10842 36
rice
(Oryza sativa)
Liliopsida Os.21406 36
bread mold
(Neurospora crassa)
Ascomycetes NCU05427 36
  • 47.18 (n)
  • 45.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5402 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10327 37
  • 48 (a)
OneToOne
Species with no ortholog for CLPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLPX Gene

ENSEMBL:
Gene Tree for CLPX (if available)
TreeFam:
Gene Tree for CLPX (if available)

Paralogs for CLPX Gene

Selected SIMAP similar genes for CLPX Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CLPX Gene

genes like me logo Genes that share paralogs with CLPX: view

No data available for Paralogs for CLPX Gene

Variants for CLPX Gene

Sequence variations from dbSNP and Humsavar for CLPX Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2414876 -- 65,155,495(+) TGCCC(A/G)CCTTG intron-variant
rs2414877 -- 65,166,940(+) ATATA(A/C/G)CAAGT intron-variant
rs2414878 -- 65,185,842(+) TGTGT(G/T)CCTTA upstream-variant-2KB
rs2919341 -- 65,151,318(+) ccagt(C/T)tgggc intron-variant
rs2919342 -- 65,173,014(+) tgttt(C/T)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPX Gene

Variant ID Type Subtype PubMed ID
esv2508866 CNV Deletion 19546169
esv2670622 CNV Deletion 23128226

Relevant External Links for CLPX Gene

HapMap Linkage Disequilibrium report
CLPX
Human Gene Mutation Database (HGMD)
CLPX

Disorders for CLPX Gene

Relevant External Links for CLPX

Genetic Association Database (GAD)
CLPX
Human Genome Epidemiology (HuGE) Navigator
CLPX
genes like me logo Genes that share disorders with CLPX: view

No data available for UniProtKB/Swiss-Prot for CLPX Gene

Publications for CLPX Gene

  1. Human and mouse mitochondrial orthologs of bacterial ClpX. (PMID: 11003706) Corydon T.J. … Bross P. (Mamm. Genome 2000) 3 4 23
  2. Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX. (PMID: 22841477) Kasashima K. … Endo H. (Exp. Cell Res. 2012) 2 3 4
  3. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. (PMID: 16115876) Kang S.G. … Maurizi M.R. (J. Biol. Chem. 2005) 3 4
  4. Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP. (PMID: 11923310) Kang S.G. … Maurizi M.R. (J. Biol. Chem. 2002) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for CLPX Gene

Sources for CLPX Gene

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