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Aliases for CLPX Gene

Aliases for CLPX Gene

  • Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit 2 3 5
  • ClpX (Caseinolytic Protease X, E. Coli) Homolog 2
  • ClpX Caseinolytic Peptidase X Homolog (E. Coli) 2
  • ClpX Caseinolytic Protease X Homolog (E. Coli) 2

External Ids for CLPX Gene

Previous GeneCards Identifiers for CLPX Gene

  • GC15M061220
  • GC15M058542
  • GC15M063019
  • GC15M063158
  • GC15M063229
  • GC15M065440
  • GC15M042267

Summaries for CLPX Gene

Entrez Gene Summary for CLPX Gene

  • The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CLPX Gene

CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit) is a Protein Coding gene. Diseases associated with CLPX include tick-borne relapsing fever and relapsing fever. GO annotations related to this gene include transcription factor binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CLPX Gene

  • ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPX Gene

Genomics for CLPX Gene

Regulatory Elements for CLPX Gene

Promoters for CLPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLPX on UCSC Golden Path with GeneCards custom track

Genomic Location for CLPX Gene

Chromosome:
15
Start:
65,148,219 bp from pter
End:
65,185,404 bp from pter
Size:
37,186 bases
Orientation:
Minus strand

Genomic View for CLPX Gene

Genes around CLPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPX Gene

Proteins for CLPX Gene

  • Protein details for CLPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76031-CLPX_HUMAN
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Protein Accession:
    O76031
    Secondary Accessions:
    • A1L428
    • A8K8F1
    • B9EGI8
    • Q9H4D9

    Protein attributes for CLPX Gene

    Size:
    633 amino acids
    Molecular mass:
    69224 Da
    Quaternary structure:
    • Homohexamer that forms a ring structure; this hexamerization requires ATP binding. Component of the Clp complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex. Interacts with TFAM.

neXtProt entry for CLPX Gene

Proteomics data for CLPX Gene at MOPED

Post-translational modifications for CLPX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPX Gene

Domains & Families for CLPX Gene

Gene Families for CLPX Gene

Protein Domains for CLPX Gene

Suggested Antigen Peptide Sequences for CLPX Gene

Graphical View of Domain Structure for InterPro Entry

O76031

UniProtKB/Swiss-Prot:

CLPX_HUMAN :
  • Belongs to the ClpX chaperone family.
Family:
  • Belongs to the ClpX chaperone family.
genes like me logo Genes that share domains with CLPX: view

Function for CLPX Gene

Molecular function for CLPX Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).

Gene Ontology (GO) - Molecular Function for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11923310
genes like me logo Genes that share ontologies with CLPX: view

Phenotypes for CLPX Gene

genes like me logo Genes that share phenotypes with CLPX: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLPX Gene

Localization for CLPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPX Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLPX Gene COMPARTMENTS Subcellular localization image for CLPX gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
chloroplast 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005743 mitochondrial inner membrane IEA,ISS --
genes like me logo Genes that share ontologies with CLPX: view

Pathways & Interactions for CLPX Gene

SuperPathways for CLPX Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLPX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLPX Gene

Drugs & Compounds for CLPX Gene

(1) Drugs for CLPX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CLPX: view

Transcripts for CLPX Gene

Unigene Clusters for CLPX Gene

ClpX caseinolytic peptidase X homolog (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLPX Gene

No ASD Table

Relevant External Links for CLPX Gene

GeneLoc Exon Structure for
CLPX
ECgene alternative splicing isoforms for
CLPX

Expression for CLPX Gene

mRNA expression in normal human tissues for CLPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLPX Gene

This gene is overexpressed in Adrenal (7.1), Liver (7.0), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLPX Gene



SOURCE GeneReport for Unigene cluster for CLPX Gene Hs.113823

mRNA Expression by UniProt/SwissProt for CLPX Gene

O76031-CLPX_HUMAN
Tissue specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
genes like me logo Genes that share expression patterns with CLPX: view

Protein tissue co-expression partners for CLPX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CLPX Gene

Orthologs for CLPX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPX 36
  • 100 (a)
OneToOne
CLPX 35
  • 99.79 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia CLPX 36
  • 98 (a)
OneToOne
CLPX 35
  • 95 (n)
  • 98.35 (a)
dog
(Canis familiaris)
Mammalia CLPX 35
  • 95.16 (n)
  • 98.42 (a)
CLPX 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clpx 16
Clpx 36
  • 96 (a)
OneToOne
Clpx 35
  • 90.42 (n)
  • 96.05 (a)
oppossum
(Monodelphis domestica)
Mammalia CLPX 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLPX 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clpx 35
  • 91.15 (n)
  • 96.21 (a)
chicken
(Gallus gallus)
Aves CLPX 36
  • 92 (a)
OneToOne
CLPX 35
  • 82.83 (n)
  • 92.37 (a)
lizard
(Anolis carolinensis)
Reptilia CLPX 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33234 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6113 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1425 35
zebrafish
(Danio rerio)
Actinopterygii wufb93b07 35
clpxa 35
  • 71 (n)
  • 84.35 (a)
clpxb 36
  • 80 (a)
OneToMany
clpxa 36
  • 89 (a)
OneToMany
CLPX (3 of 3) 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002996 35
  • 60.55 (n)
  • 69.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4538 36
  • 50 (a)
OneToOne
CG4538 35
  • 59.21 (n)
  • 66.46 (a)
CG4538 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea K07A3.3 36
  • 39 (a)
OneToMany
D2030.2 36
  • 41 (a)
OneToMany
K07A3.3 37
  • 41 (a)
D2030.2 37
  • 42 (a)
D2030.2 35
  • 53.37 (n)
  • 46.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCX1 38
MCX1 36
  • 37 (a)
OneToOne
MCX1 35
  • 51.8 (n)
  • 43.19 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09691g 35
  • 51.93 (n)
  • 47.04 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10842 35
rice
(Oryza sativa)
Liliopsida Os.21406 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05427 35
  • 47.18 (n)
  • 45.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5402 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10327 36
  • 48 (a)
OneToOne
Species with no ortholog for CLPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLPX Gene

ENSEMBL:
Gene Tree for CLPX (if available)
TreeFam:
Gene Tree for CLPX (if available)

Paralogs for CLPX Gene

(1) SIMAP similar genes for CLPX Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CLPX Gene

genes like me logo Genes that share paralogs with CLPX: view

No data available for Paralogs for CLPX Gene

Variants for CLPX Gene

Sequence variations from dbSNP and Humsavar for CLPX Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs35754835 - 65,154,930(+) ACTCA(A/G)TCAGA reference, missense
rs2945608 -- 65,169,734(-) TACAT(C/T)CTATA intron-variant
rs2946667 -- 65,150,141(+) TGTAA(A/C)CTCTG downstream-variant-500B
rs2946668 -- 65,151,294(+) aagcc(A/G)aaatc intron-variant
rs2946669 -- 65,151,305(+) atacc(A/C)ctgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPX Gene

Variant ID Type Subtype PubMed ID
esv2508866 CNV Deletion 19546169
esv2670622 CNV Deletion 23128226

Variation tolerance for CLPX Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPX Gene

HapMap Linkage Disequilibrium report
CLPX
Human Gene Mutation Database (HGMD)
CLPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPX Gene

Disorders for CLPX Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLPX Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick-borne relapsing fever
  • relapsing fever, tick-borne
relapsing fever
- elite association - COSMIC cancer census association via MalaCards
Search CLPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLPX

Genetic Association Database (GAD)
CLPX
Human Genome Epidemiology (HuGE) Navigator
CLPX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPX
genes like me logo Genes that share disorders with CLPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPX Gene

Publications for CLPX Gene

  1. Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX. (PMID: 22841477) Kasashima K. … Endo H. (Exp. Cell Res. 2012) 2 3 4 67
  2. Human and mouse mitochondrial orthologs of bacterial ClpX. (PMID: 11003706) Corydon T.J. … Bross P. (Mamm. Genome 2000) 3 23
  3. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for CLPX Gene

Sources for CLPX Gene

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