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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLPX Gene

protein-coding   GIFtS: 54
GCID: GC15M065440

Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit

(Previous names: ClpX (caseinolytic protease X, E. coli) homolog, ClpX caseinolytic...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit1 2     ATP-Dependent Clp Protease ATP-Binding Subunit ClpX-Like, Mitochondrial2
ClpX (Caseinolytic Protease X, E. Coli) Homolog1     ClpX Caseinolytic Peptidase X Homolog2
ClpX Caseinolytic Peptidase X Homolog (E. Coli)1     ClpX Caseinolytic Protease X Homolog2
ClpX Caseinolytic Protease X Homolog (E. Coli)1     Energy-Dependent Regulator Of Proteolysis2

External Ids:    HGNC: 20881   Entrez Gene: 108452   Ensembl: ENSG000001668557   UniProtKB: O760313   

Export aliases for CLPX gene to outside databases

Previous GC identifers: GC15M061220 GC15M058542 GC15M063019 GC15M063158 GC15M063229 GC15M042267


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CLPX Gene: 
CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) is a protein-coding gene. Diseases associated with CLPX include pneumonia, and tuberculosis. GO annotations related to this gene include unfolded protein binding and peptidase activator activity.

UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
Function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates.
Can perform chaperone functions in the absence of clpP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLPX gene promoter:
         HOXA9B   HOXA9   MyoD   STAT5A   Meis-1b   C/EBPalpha   PPAR-alpha   IRF-2   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPX promoter sequence
   Search SABiosciences Chromatin IP Primers for CLPX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

CLPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPX gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065440:  view genomic region     (about GC identifiers)

Start:
65,440,557 bp from pter      End:
65,477,680 bp from pter
Size:
37,124 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031 (See protein sequence)
Recommended Name: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor  
Size: 633 amino acids; 69224 Da
Subunit: Heterodimer of clpP and clpX (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: A1L428 A8K8F1 B9EGI8 Q9H4D9

Explore the universe of human proteins at neXtProt for CLPX: NX_O76031

Explore proteomics data for CLPX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76031

  • CLPX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLPX Protein Expression
    REFSEQ proteins: NP_006651.2  
    ENSEMBL proteins: 
     ENSP00000300107   ENSP00000453461   ENSP00000452611  

    Human Recombinant Protein Products for CLPX: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLPX
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLPX 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion NAS11923310
    GO:0005743mitochondrial inner membrane ISS--
    GO:0009841mitochondrial endopeptidase Clp complex IDA16115876

    CLPX for ontologies           About GeneDecksing



    CLPX Antibody Products: 
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    Novus Biologicals CLPX Antibody
    Abcam antibodies for CLPX
    Cloud-Clone Corp. Antibodies for CLPX 
    ThermoFisher Antibody for CLPX
    LSBio Antibodies in human, mouse, rat for CLPX 

    Assay Products for CLPX: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CLPX 
    Cloud-Clone Corp. CLIAs for CLPX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR019489 Clp_ATPase_C
     IPR013093 ATPase_AAA-2
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR004487 Clp_protease_ATP-bd_su_ClpX

    Graphical View of Domain Structure for InterPro Entry O76031

    ProtoNet protein and cluster: O76031

    UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
    Similarity: Belongs to the ClpX chaperone family


    CLPX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLPX_HUMAN, O76031
    Function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates.
    Can perform chaperone functions in the absence of clpP (By similarity)

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004176contributes to ATP-dependent peptidase activity IDA16115876
    GO:0005515protein binding IPI11923310
    GO:0005524ATP binding ISS--
    GO:0008134transcription factor binding ----
         
    CLPX for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLPX:
     Decreased circadian period len  Synthetic lethal with Ras  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLPX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLPX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLPX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLPX 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPX
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPX:
    hsa-miR-591 hsa-miR-3674 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCLPX 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLPX
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLPX

    Clone
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    OriGene ORF clones in mouse, rat for CLPX
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    GenScript: all cDNA clones in your preferred vector: CLPX (NM_006660)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPX
    Sirion Biotech Customized lentivirus for stable overexpression of CLPX 
                         Customized lentivirus expression plasmids for stable overexpression of CLPX 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLPX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/348 Interacting proteins for CLPX (O760312, 3 ENSP000003001074) via UniProtKB, MINT, STRING, and/or I2D (see all 348)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLDIP2Q9Y2S72, 3MINT-8079030 I2D: score=2 
    LONP1P367762, 3MINT-8079030 I2D: score=1 
    RARS2Q5T1602, 3MINT-8079030 I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006457protein folding IEA--
    GO:0010952positive regulation of peptidase activity IDA11923310
    GO:0051603proteolysis involved in cellular protein catabolic process IDA16115876

    CLPX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLPX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLPX

    1 Novoseek inferred chemical compound relationship for CLPX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 33.1 6 19549599 (1), 19892734 (1), 12937164 (1), 15064753 (1)

    Search CenterWatch for drugs/clinical trials and news about CLPX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLPX gene: 
    NM_006660.3  

    Unigene Cluster for CLPX:

    ClpX caseinolytic peptidase X homolog (E. coli)
    Hs.113823  [show with all ESTs]
    Unigene Representative Sequence: AL136922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300107(uc002aom.3 uc010uiu.2) ENST00000559152 ENST00000560166
    ENST00000558958(uc010bhg.1) ENST00000558103 ENST00000559218
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPX
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPX:
    hsa-miR-591 hsa-miR-3674 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidCLPX 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLPX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPX
    Clone
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    OriGene clones in human, mouse for CLPX (see all 6)
    OriGene ORF clones in mouse, rat for CLPX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLPX (NM_006660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPX
    Sirion Biotech Customized lentivirus for stable overexpression of CLPX 
                         Customized lentivirus expression plasmids for stable overexpression of CLPX 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLPX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLPX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPX

    Additional mRNA sequence: 

    AJ006267.3 AK292316.1 AK308133.1 AK310614.1 AL136922.1 BC130373.1 BC136487.1 BC144166.1 

    6 DOTS entries:

    DT.414576  DT.409982  DT.40230324  DT.102829467  DT.92418842  DT.99953126 

    24/146 AceView cDNA sequences (see all 146):

    BU508492 AW020766 AV651180 BF222305 CN483221 BG503457 BM454677 CA430278 
    AA257016 AI499357 AV651185 AL136922 AA226925 BG502968 CA448123 CB852812 
    AW614246 AI223970 NM_006660 AA678577 AU279705 BM784002 AA974097 BF477638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLPX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATAATTG
    CLPX Expression
    About this image


    See CLPX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLPX

    SOURCE GeneReport for Unigene cluster: Hs.113823

    UniProtKB/Swiss-Prot: CLPX_HUMAN, O76031
    Tissue specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain,
    placenta, lung, kidney and pancreas

        SABiosciences Custom PCR Arrays for CLPX
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLPX gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clpx1 , 5 caseinolytic peptidase X (E.coli)1, 5 90.42(n)1
    96.05(a)1
      9 (35.22 cM)5
    2701661  NM_011802.21  NP_035932.21 
     652942605 
    chicken
    (Gallus gallus)
    Aves CLPX1 ClpX caseinolytic peptidase X homolog (E. coli) 82.83(n)
    92.37(a)
      415527  NM_001030552.1  NP_001025723.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLPX6
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343392.1(303001-327196)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.332342 Xenopus laevis transcribed sequence with moderate similarity more 75(n)    48013092 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb93b072 Transcribed sequence with moderate similarity to protein more 76.74(n)    57044018 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45381 , 3 endopeptidase Clp3
    CG45381
    60(a)3
    55.8(n)1
    60.17(a)1
      92B63
    423691  NM_169880.11  NP_732463.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D2030.21 , 3 ATP-dependent CLP protease (CLPX) like3
    Protein D2030.21
    42(a)
    (best of 2)3
    52.89(n)1
    46.39(a)1
      I(7582340-7586399)3
    1725111  NM_001025905.21  NP_001021076.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCX1(YBR227C)4
    MCX11
    Mitochondrial matrix protein; putative ATP-binding more4
    Mcx1p1
    51.63(n)1
    43.02(a)1
      2(675134-673572)4
    8525281, 4  NP_009786.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CLPX1 CLP protease regulatory subunit X 57.72(n)
    54.25(a)
      835416  NM_124714.3  NP_568792.1 
    rice
    (Oryza sativa)
    Liliopsida Os.214062 Transcribed sequence with moderate similarity to protein more 75.97(n)    CB617934.1 


    ENSEMBL Gene Tree for CLPX (if available)
    TreeFam Gene Tree for CLPX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLPX gene
    1 SIMAP similar gene for CLPX using alignment to 3 protein entries:     CLPX_HUMAN (see all proteins):
    DKFZp586J151

    CLPX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLPX
    PGOHUM00000240694


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/720 SNPs in CLPX are shown (see all 720)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908879191,2
    --65442434(+) ACTTTA/GTCGCC 1 -- ds50010--------
    rs1491464711,2
    C--65442461(+) GGCACA/GACCTC 1 -- ds50010--------
    rs29466671,2
    C,A--65442479(+) TGTAAC/ACTCTG 1 -- ds50018Minor allele frequency- A:0.22NA WA CSA 133
    rs129099811,2
    C,F--65442523(+) CTCCCA/GAGTAG 1 -- ds50015Minor allele frequency- G:0.30NA CSA 10
    rs1840372641,2
    --65442648(+) CGCCTC/TGGCCT 1 -- ds50010--------
    rs1115149451,2
    F--65442676(+) ACAGGC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1929943871,2
    C--65442705(+) CTGGTC/TCAATT 1 -- ds50010--------
    rs1149313531,2
    C,F--65442984(+) CTTCCG/ATAAAA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs734750431,2
    C,F--65443063(+) TATCCA/CAGATA 1 -- ut312Minor allele frequency- C:0.04WA 120
    rs1388434371,2
    --65443077(+) CCAATA/GCCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLPX (65440557 - 65477680 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLPX:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670622CNV Deletion23128226
    esv2508866CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLPX
    DNA2.0 Custom Variant and Variant Library Synthesis for CLPX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CLPX:    About MalaCards
    pneumonia    tuberculosis


    CLPX for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLPX
    Human Genome Epidemiology (HuGE) Navigator: CLPX (1 document)

    Export disorders for CLPX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLPX gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with CLPX)
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    1. Human and mouse mitochondrial orthologs of bacterial ClpX. (PubMed id 11003706)1, 2, 9 Corydon T.J.... Bross P. (2000)
    2. Maintenance of mitochondrial genome distribution by mi tochondrial AAA+ protein ClpX. (PubMed id 22841477)1, 3 Kasashima K....Endo H. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. p32/gC1qR is indispensable for fetal development and m itochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (2012)
    5. Substrate recognition and processing by a Walker B mut ant of the human mitochondrial AAA+ protein CLPX. (PubMed id 22710082)1 Lowth B.R....Dougan D.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    8. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10845 HGNC: 2088 AceView: CLPX Ensembl:ENSG00000166855 euGenes: HUgn10845
    ECgene: CLPX H-InvDB: CLPX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLPX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLPX gene:
    Search GeneIP for patents involving CLPX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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