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Aliases for CLPX Gene

Aliases for CLPX Gene

  • Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit 2 3 5
  • ClpX (Caseinolytic Protease X, E. Coli) Homolog 2
  • ClpX Caseinolytic Peptidase X Homolog (E. Coli) 2
  • ClpX Caseinolytic Protease X Homolog (E. Coli) 2

External Ids for CLPX Gene

Previous GeneCards Identifiers for CLPX Gene

  • GC15M061220
  • GC15M058542
  • GC15M063019
  • GC15M063158
  • GC15M063229
  • GC15M065440
  • GC15M042267

Summaries for CLPX Gene

Entrez Gene Summary for CLPX Gene

  • The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CLPX Gene

CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit) is a Protein Coding gene. Diseases associated with CLPX include Tick-Borne Relapsing Fever and Relapsing Fever. GO annotations related to this gene include transcription factor binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CLPX Gene

  • ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).

Additional gene information for CLPX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPX Gene

Genomics for CLPX Gene

Regulatory Elements for CLPX Gene

Enhancers for CLPX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H065303 1.8 FANTOM5 ENCODE dbSUPER 11.3 -119.1 -119068 2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 PARP16 ZNF609 PDCD7 INTS14 TRIP4 SLC24A1 CILP CSNK1G1 ENSG00000264937 ENSG00000259635
GH15H065274 1.1 Ensembl ENCODE 11.3 -90.2 -90234 1 HDAC1 FOXA2 THRB ZNF366 SCRT2 FOS ATF7 NCOA1 ZEB2 MTA1 PARP16 RNU5B-1 RNU6-686P CILP CLPX IGDCC3 SNORA24B
GH15H065110 1.1 FANTOM5 ENCODE 10.7 +74.7 74715 0 HDAC1 PKNOX1 ATF1 TAL1 JUN ETV1 CEBPG ZIC2 TCF12 CTBP1 MTFMT CLPX RBPMS2 ANKDD1A PDCD7 UBAP1L ENSG00000259258
GH15H065244 1 Ensembl ENCODE 10.7 -60.4 -60447 2 ELF3 DRAP1 PKNOX1 FOXA2 SAP130 ARID4B TEAD3 ZNF664 ZNF121 ATF7 CILP CLPX SPG21 RNU6-686P SNORA24B
GH15H065248 0.7 ENCODE 10.7 -63.7 -63698 2 NR2F1 DPF2 BATF RELA ZFHX2 IKZF1 EED GLIS1 MLLT1 ATF7 CILP CLPX PARP16 IGDCC3 RNU6-686P SNORA24B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLPX on UCSC Golden Path with GeneCards custom track

Promoters for CLPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078049 704 2601 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 CBX5 ZNF207 ZNF143

Genomic Location for CLPX Gene

Chromosome:
15
Start:
65,148,219 bp from pter
End:
65,185,404 bp from pter
Size:
37,186 bases
Orientation:
Minus strand

Genomic View for CLPX Gene

Genes around CLPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPX Gene

Proteins for CLPX Gene

  • Protein details for CLPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76031-CLPX_HUMAN
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Protein Accession:
    O76031
    Secondary Accessions:
    • A1L428
    • A8K8F1
    • B9EGI8
    • Q9H4D9

    Protein attributes for CLPX Gene

    Size:
    633 amino acids
    Molecular mass:
    69224 Da
    Quaternary structure:
    • Homohexamer that forms a ring structure; this hexamerization requires ATP binding. Component of the Clp complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex. Interacts with TFAM.

neXtProt entry for CLPX Gene

Post-translational modifications for CLPX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPX Gene

No data available for DME Specific Peptides for CLPX Gene

Domains & Families for CLPX Gene

Gene Families for CLPX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CLPX Gene

Graphical View of Domain Structure for InterPro Entry

O76031

UniProtKB/Swiss-Prot:

CLPX_HUMAN :
  • Belongs to the ClpX chaperone family.
Family:
  • Belongs to the ClpX chaperone family.
genes like me logo Genes that share domains with CLPX: view

Function for CLPX Gene

Molecular function for CLPX Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).

Gene Ontology (GO) - Molecular Function for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004176 contributes_to ATP-dependent peptidase activity IDA 16115876
GO:0005515 protein binding IPI 11923310
GO:0005524 ATP binding ISS,IEA --
GO:0016504 peptidase activator activity IDA 11923310
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with CLPX: view

Phenotypes for CLPX Gene

genes like me logo Genes that share phenotypes with CLPX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLPX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLPX Gene

Localization for CLPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPX Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPX gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 11003706
GO:0005743 mitochondrial inner membrane ISS,IEA --
GO:0005759 mitochondrial matrix IDA 10525407
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CLPX: view

Pathways & Interactions for CLPX Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0010952 positive regulation of peptidase activity IEA --
GO:0046034 ATP metabolic process IDA 22710082
GO:0051603 proteolysis involved in cellular protein catabolic process IDA 16115876
genes like me logo Genes that share ontologies with CLPX: view

No data available for Pathways by source and SIGNOR curated interactions for CLPX Gene

Drugs & Compounds for CLPX Gene

(1) Drugs for CLPX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CLPX: view

Transcripts for CLPX Gene

Unigene Clusters for CLPX Gene

ClpX caseinolytic peptidase X homolog (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLPX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CLPX Gene

No ASD Table

Relevant External Links for CLPX Gene

GeneLoc Exon Structure for
CLPX
ECgene alternative splicing isoforms for
CLPX

Expression for CLPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLPX Gene

This gene is overexpressed in Adrenal (7.1), Liver (7.0), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLPX Gene



Protein tissue co-expression partners for CLPX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLPX Gene:

CLPX

SOURCE GeneReport for Unigene cluster for CLPX Gene:

Hs.113823

mRNA Expression by UniProt/SwissProt for CLPX Gene:

O76031-CLPX_HUMAN
Tissue specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.

Evidence on tissue expression from TISSUES for CLPX Gene

  • Liver(4.4)
  • Muscle(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CLPX: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPX Gene

Orthologs for CLPX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPX 33 34
  • 99.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CLPX 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLPX 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLPX 33 34
  • 95.16 (n)
cow
(Bos Taurus)
Mammalia CLPX 33 34
  • 95 (n)
rat
(Rattus norvegicus)
Mammalia Clpx 33
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Clpx 33 16 34
  • 90.42 (n)
chicken
(Gallus gallus)
Aves CLPX 33 34
  • 82.83 (n)
lizard
(Anolis carolinensis)
Reptilia CLPX 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6113 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33234 33
zebrafish
(Danio rerio)
Actinopterygii clpxb 34
  • 80 (a)
OneToMany
clpxa 33 34
  • 71 (n)
CLPX (3 of 3) 34
  • 71 (a)
OneToMany
wufb93b07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1425 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002996 33
  • 60.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4538 35 33 34
  • 59.21 (n)
worm
(Caenorhabditis elegans)
Secernentea D2030.2 35 33 34
  • 53.37 (n)
K07A3.3 35 34
  • 41 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09691g 33
  • 51.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCX1 33 34 36
  • 51.8 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.10842 33
rice
(Oryza sativa)
Liliopsida Os.21406 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10327 34
  • 48 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU05427 33
  • 47.18 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5402 33
Species where no ortholog for CLPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLPX Gene

ENSEMBL:
Gene Tree for CLPX (if available)
TreeFam:
Gene Tree for CLPX (if available)

Paralogs for CLPX Gene

(1) SIMAP similar genes for CLPX Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CLPX Gene

genes like me logo Genes that share paralogs with CLPX: view

No data available for Paralogs for CLPX Gene

Variants for CLPX Gene

Sequence variations from dbSNP and Humsavar for CLPX Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000032302 -- 65,183,258(+) GAGAT(C/G)GAGAC intron-variant
rs1000049853 -- 65,155,423(+) TTTTT(G/T)TATTT intron-variant
rs1000061659 -- 65,177,596(+) GACAC(C/T)GAAGT intron-variant
rs1000115677 -- 65,148,637(+) AAAGA(A/G)AGCCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000130065 -- 65,184,482(+) CGGGG(C/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPX Gene

Variant ID Type Subtype PubMed ID
esv2508866 CNV deletion 19546169
esv2670622 CNV deletion 23128226
esv3636750 CNV loss 21293372
nsv474816 CNV novel sequence insertion 20440878
nsv569704 CNV loss 21841781

Variation tolerance for CLPX Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPX Gene

Human Gene Mutation Database (HGMD)
CLPX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPX Gene

Disorders for CLPX Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLPX Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
tick-borne relapsing fever
  • relapsing fever, tick-borne
relapsing fever
- elite association - COSMIC cancer census association via MalaCards
Search CLPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLPX

Genetic Association Database (GAD)
CLPX
Human Genome Epidemiology (HuGE) Navigator
CLPX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPX
genes like me logo Genes that share disorders with CLPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPX Gene

Publications for CLPX Gene

  1. Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX. (PMID: 22841477) Kasashima K … Endo H (Experimental cell research 2012) 2 3 4 60
  2. Human and mouse mitochondrial orthologs of bacterial ClpX. (PMID: 11003706) Corydon TJ … Bross P (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 3 4 22 60
  3. Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. (PMID: 22710082) Lowth BR … Dougan DA (Journal of structural biology 2012) 3 4 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. (PMID: 16115876) Kang SG … Maurizi MR (The Journal of biological chemistry 2005) 3 4 60

Products for CLPX Gene

Sources for CLPX Gene

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