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Aliases for CLPTM1L Gene

Aliases for CLPTM1L Gene

  • CLPTM1-Like 2 3
  • CRR9 3 4 6
  • Cisplatin Resistance-Related Protein 9 3 4
  • CLPTM1-Like Protein 3 4
  • CRR9p 3 4
  • Cleft Lip And Palate Transmembrane Protein 1-Like Protein 3
  • Cisplatin Resistance Related Protein CRR9p 3
  • Cisplatin Resistance Related Protein 2

External Ids for CLPTM1L Gene

Previous GeneCards Identifiers for CLPTM1L Gene

  • GC05M001371

Summaries for CLPTM1L Gene

GeneCards Summary for CLPTM1L Gene

CLPTM1L (CLPTM1-Like) is a Protein Coding gene. Diseases associated with CLPTM1L include cleft lip and lung cancer. An important paralog of this gene is CLPTM1.

UniProtKB/Swiss-Prot for CLPTM1L Gene

  • Enhances cisplatin-mediated apoptosis, when overexpressed.

Gene Wiki entry for CLPTM1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPTM1L Gene

Genomics for CLPTM1L Gene

Regulatory Elements for CLPTM1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLPTM1L Gene

1,317,744 bp from pter
1,345,099 bp from pter
27,356 bases
Minus strand

Genomic View for CLPTM1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLPTM1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPTM1L Gene

Proteins for CLPTM1L Gene

  • Protein details for CLPTM1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cleft lip and palate transmembrane protein 1-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DTC1
    • Q658W6
    • Q7LG29
    • Q96AZ0
    • Q9H3N4

    Protein attributes for CLPTM1L Gene

    538 amino acids
    Molecular mass:
    62229 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB20083.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLPTM1L Gene


neXtProt entry for CLPTM1L Gene

Proteomics data for CLPTM1L Gene at MOPED

Post-translational modifications for CLPTM1L Gene

  • Ubiquitination at Lys199, Lys205, Lys243, Lys467, and Lys530
  • Glycosylation at Asn91, Asn101, and Asn229
  • Modification sites at PhosphoSitePlus

Other Protein References for CLPTM1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPTM1L Gene

Domains for CLPTM1L Gene

Protein Domains for CLPTM1L Gene


Suggested Antigen Peptide Sequences for CLPTM1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CLPTM1 family.
  • Belongs to the CLPTM1 family.
genes like me logo Genes that share domains with CLPTM1L: view

No data available for Gene Families for CLPTM1L Gene

Function for CLPTM1L Gene

Molecular function for CLPTM1L Gene

UniProtKB/Swiss-Prot Function:
Enhances cisplatin-mediated apoptosis, when overexpressed.
UniProtKB/Swiss-Prot Induction:
Up-regulated by cisplatin.

Animal Model Products

CRISPR Products

miRNA for CLPTM1L Gene

miRTarBase miRNAs that target CLPTM1L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLPTM1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLPTM1L Gene

Localization for CLPTM1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPTM1L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CLPTM1L Gene COMPARTMENTS Subcellular localization image for CLPTM1L gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLPTM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLPTM1L: view

Pathways for CLPTM1L Gene

SuperPathways for CLPTM1L Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat

Gene Ontology (GO) - Biological Process for CLPTM1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CLPTM1L: view

No data available for Pathways by source for CLPTM1L Gene

Transcripts for CLPTM1L Gene

Unigene Clusters for CLPTM1L Gene

Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLPTM1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPTM1L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP6: - -
SP7: - - -
SP8: - - -
SP9: -
SP10: - - - -
SP12: -
SP13: - -

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d

Relevant External Links for CLPTM1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLPTM1L Gene

mRNA expression in normal human tissues for CLPTM1L Gene

Protein differential expression in normal tissues for CLPTM1L Gene

This gene is overexpressed in Nasal epithelium (35.0) and Cervix (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLPTM1L Gene

SOURCE GeneReport for Unigene cluster for CLPTM1L Gene Hs.444673

genes like me logo Genes that share expressions with CLPTM1L: view

Expression partners for CLPTM1L Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLPTM1L Gene

Orthologs for CLPTM1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLPTM1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLPTM1L 35
  • 87.61 (n)
  • 92.01 (a)
  • 92 (a)
(Canis familiaris)
Mammalia CLPTM1L 35
  • 87.98 (n)
  • 95.17 (a)
  • 94 (a)
(Mus musculus)
Mammalia Clptm1l 35
  • 86.99 (n)
  • 92.94 (a)
Clptm1l 16
Clptm1l 36
  • 92 (a)
(Pan troglodytes)
Mammalia CLPTM1L 35
  • 97.41 (n)
  • 97.21 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Clptm1l 35
  • 87.48 (n)
  • 94.61 (a)
(Monodelphis domestica)
Mammalia CLPTM1L 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CLPTM1L 36
  • 91 (a)
(Gallus gallus)
Aves CLPTM1L 35
  • 78.51 (n)
  • 90.55 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia CLPTM1L 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clptm1l 35
  • 73.83 (n)
  • 86.92 (a)
(Danio rerio)
Actinopterygii clptm1l 35
  • 71.68 (n)
  • 74.44 (a)
Dr.7344 35
clptm1l 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001492 35
  • 54.26 (n)
  • 47.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4332 35
  • 54.36 (n)
  • 50.51 (a)
CG4332 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea T13H5.8 35
  • 52.12 (n)
  • 49.36 (a)
T13H5.8 36
  • 41 (a)
(Glycine max)
eudicotyledons Gma.5135 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1984 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.832 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5840 36
  • 48 (a)
Species with no ortholog for CLPTM1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLPTM1L Gene

Gene Tree for CLPTM1L (if available)
Gene Tree for CLPTM1L (if available)

Paralogs for CLPTM1L Gene

Paralogs for CLPTM1L Gene

(1) SIMAP similar genes for CLPTM1L Gene using alignment to 2 proteins: Pseudogenes for CLPTM1L Gene

genes like me logo Genes that share paralogs with CLPTM1L: view

Variants for CLPTM1L Gene

Sequence variations from dbSNP and Humsavar for CLPTM1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27069 -- 1,347,013(-) TTGCC(A/G)GCAGC upstream-variant-2KB
rs27070 -- 1,346,188(-) GGTAG(C/G)CGAAA upstream-variant-2KB
rs27071 -- 1,345,966(-) CAGCC(A/G)AGTCC upstream-variant-2KB
rs27996 -- 1,345,359(-) GCTCC(C/T)CACAC upstream-variant-2KB
rs31484 -- 1,337,791(+) AAAGC(A/T)CCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPTM1L Gene

Variant ID Type Subtype PubMed ID
nsv881117 CNV Loss 21882294
nsv510895 CNV Complex 20534489
nsv880847 CNV Loss 21882294
nsv822959 CNV Loss 20364138
nsv509045 CNV Insertion 20534489
nsv880418 CNV Loss 21882294
nsv881444 CNV Loss 21882294
nsv830187 CNV Loss 17160897
esv2729477 CNV Deletion 23290073
esv2658912 CNV Deletion 23128226
esv23092 CNV Loss 19812545
esv2729478 CNV Deletion 23290073
esv27773 CNV Gain 19812545
nsv4679 CNV Insertion 18451855
esv1008075 CNV Loss 20482838
esv24171 CNV Loss 19812545
nsv820391 CNV Duplication 20802225
esv2671207 CNV Deletion 23128226
esv2729479 CNV Deletion 23290073
esv1013304 CNV Insertion 17803354
esv1673870 CNV Insertion 17803354
esv1331109 CNV Insertion 17803354
esv1039127 CNV Insertion 17803354
esv1783268 CNV Insertion 17803354

Relevant External Links for CLPTM1L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPTM1L Gene

Disorders for CLPTM1L Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CLPTM1L Gene in MalaCards »

(2) Diseases for CLPTM1L Gene

Relevant External Links for CLPTM1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLPTM1L: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLPTM1L Gene

Publications for CLPTM1L Gene

  1. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. (PMID: 11162647) Yamamoto K. … Ohtake Y. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Genetic correction of PSA values using sequence variants associated with PSA levels. (PMID: 21160077) Gudmundsson J. … Stefansson K. (Sci Transl Med 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. (PMID: 18978787) Wang Y. … Houlston R.S. (Nat. Genet. 2008) 3 48
  5. Lung cancer susceptibility locus at 5p15.33. (PMID: 18978790) McKay J.D. … Brennan P. (Nat. Genet. 2008) 3 48

Products for CLPTM1L Gene

Sources for CLPTM1L Gene

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