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CLPTM1L Gene

protein-coding   GIFtS: 52
GCID: GC05M001317

CLPTM1-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CLPTM1-like1 2     CLPTM1-Like Protein2 3
CRR92 3 5     Cisplatin Resistance Related Protein1
Cisplatin Resistance-Related Protein 92 3     Cisplatin Resistance Related Protein CRR9p2
CRR9p2 3     Cleft Lip And Palate Transmembrane Protein 1-Like Protein2

External Ids:    HGNC: 243081   Entrez Gene: 810372   Ensembl: ENSG000000496567   OMIM: 6125855   UniProtKB: Q96KA53   

Export aliases for CLPTM1L gene to outside databases

Previous GC identifer: GC05M001371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLPTM1L Gene:
CLPTM1L (CLPTM1-like) is a protein-coding gene. Diseases associated with CLPTM1L include estrogen-receptor negative breast cancer, and cleft lip. An important paralog of this gene is CLPTM1.

UniProtKB/Swiss-Prot: CLP1L_HUMAN, Q96KA5
Function: Enhances cisplatin-mediated apoptosis, when overexpressed

Gene Wiki entry for CLPTM1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  NT_187547.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLPTM1L gene promoter:
         GCNF   MyoD   CUTL1   E47   GATA-2   CREB   deltaCREB   GCNF-1   TGIF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPTM1L promoter sequence
   Search Chromatin IP Primers for CLPTM1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLPTM1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

CLPTM1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPTM1L gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001317:  view genomic region     (about GC identifiers)

Start:
1,317,859 bp from pter      End:
1,345,214 bp from pter
Size:
27,356 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLP1L_HUMAN, Q96KA5 (See protein sequence)
Recommended Name: Cleft lip and palate transmembrane protein 1-like protein  
Size: 538 amino acids; 62229 Da
Sequence caution: Sequence=BAB20083.1; Type=Erroneous initiation;
Secondary accessions: D3DTC1 Q658W6 Q7LG29 Q96AZ0 Q9H3N4
Alternative splicing: 2 isoforms:  Q96KA5-1   Q96KA5-2   

Explore the universe of human proteins at neXtProt for CLPTM1L: NX_Q96KA5

Explore proteomics data for CLPTM1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys199, Lys205, Lys243, Lys467, Lys530
  • Glycosylation2 at Asn91, Asn101, Asn229
  • Modification sites at PhosphoSitePlus

  • See CLPTM1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110409.2  
    ENSEMBL proteins: 
     ENSP00000313854   ENSP00000423321   ENSP00000315196  

    CLPTM1L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008429 CLPTM1

    Graphical View of Domain Structure for InterPro Entry Q96KA5

    ProtoNet protein and cluster: Q96KA5

    UniProtKB/Swiss-Prot: CLP1L_HUMAN, Q96KA5
    Similarity: Belongs to the CLPTM1 family


    CLPTM1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLP1L_HUMAN, Q96KA5
    Function: Enhances cisplatin-mediated apoptosis, when overexpressed
    Induction: Up-regulated by cisplatin

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLPTM1L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLPTM1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLPTM1L

    miRNA
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    miRTarBase miRNAs that target CLPTM1L:
    hsa-mir-22-3p (MIRT050451)

    Block miRNA regulation of human, mouse, rat CLPTM1L using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CLPTM1L:
    hsa-miR-640 hsa-miR-182 hsa-miR-539 hsa-miR-494 hsa-miR-3121-3p hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidCLPTM1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLPTM1L

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPTM1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLP1L_HUMAN, Q96KA5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CLPTM1L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CLPTM1L: 
              Cancer Drug Resistance in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CLPTM1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CLPTM1L (Q96KA53 ENSP000003138544) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3C3Q8NEB93, ENSP000002620394I2D: score=3 STRING: ENSP00000262039
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    SNRPGP623083I2D: score=4 
    CLN3Q132863I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    CLPTM1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLPTM1L (CLP1L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLPTM1L gene: 
    NM_030782.3  

    Unigene Cluster for CLPTM1L:

    CLPTM1-like
    Hs.444673  [show with all ESTs]
    Unigene Representative Sequence: AK128462
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320895(uc003jch.3) ENST00000507807 ENST00000503042 ENST00000503534
    ENST00000515719 ENST00000506641 ENST00000511268 ENST00000512451 ENST00000507195
    ENST00000505914 ENST00000505605 ENST00000503151 ENST00000508765 ENST00000513250
    ENST00000511786 ENST00000320927(uc003jcg.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CLPTM1L using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CLPTM1L:
    hsa-miR-640 hsa-miR-182 hsa-miR-539 hsa-miR-494 hsa-miR-3121-3p hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidCLPTM1L 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CLPTM1L
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLPTM1L (NM_030782)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPTM1L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLPTM1L
      QuantiTect SYBR Green Assays in human, mouse, rat CLPTM1L
      QuantiFast Probe-based Assays in human, mouse, rat CLPTM1L

    Additional mRNA sequence: 

    AB045223.1 AK027306.1 AK057095.1 AK126225.1 AK128462.1 AL137440.1 AL832953.1 BC016399.1 
    BC025305.1 BC040705.1 

    22 DOTS entries:

    DT.418580  DT.100700923  DT.97809458  DT.97773724  DT.92065968  DT.100791241  DT.101985140  DT.97862279 
    DT.120823942  DT.97862280  DT.91758381  DT.95362057  DT.120823984  DT.75121977  DT.91834524  DT.95172160 
    DT.97786715  DT.101956405  DT.95362061  DT.97817856  DT.100790899  DT.95221136 

    Selected AceView cDNA sequences (see all 417):

    BU538292 AA530996 BQ061808 CD107068 AL832953 BM930836 CB128331 BM788255 
    BM822436 BC025305 AI701301 BM856707 BQ066342 AI027712 BX332026 BQ222588 
    BQ683777 BQ935485 BF983770 BI258144 BG056311 BM473036 BM740425 AA024859 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLPTM1L (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                                              -                                               -           -           -     -               
    SP2:                                                              -                                               -           -     -     -     -               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                      -     -               
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c · 21d
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for CLPTM1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLPTM1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTGGGA
    CLPTM1L Expression
    About this image

    CLPTM1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLPTM1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444673
        Pathway & Disease-focused RT2 Profiler PCR Array including CLPTM1L: 
              Cancer Drug Resistance in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat CLPTM1L
    QuantiFast Probe-based Assays in human, mouse, rat CLPTM1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPTM1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLPTM1L gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clptm1l1 , 5 CLPTM1-like1, 5 86.99(n)1
    92.94(a)1
      13 (40.12 cM)5
    2183351  NM_146047.21  NP_666159.21 
     736040025 
    chicken
    (Gallus gallus)
    Aves CLPTM1L1 CLPTM1-like 78.51(n)
    90.55(a)
      420973  NM_001012864.1  NP_001012882.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLPTM1L6
    CLPTM1-like
    74(a)
    1 ↔ 1
    4(68195935-68231917)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clptm1l1 CLPTM1-like 73.83(n)
    86.92(a)
      780231  NM_001126072.1  NP_001119544.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.73442 Transcribed sequence with weak similarity to protein more 78.26(n)    57063849 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG43321 CG4332 54.36(n)
    50.51(a)
      32267  NM_132633.3  NP_572861.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T13H5.81 T13H5.8 52.12(n)
    49.36(a)
      174362  NM_063396.4  NP_495797.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.51352 Transcribed sequence with moderate similarity to protein more 69.89(n)  


    ENSEMBL Gene Tree for CLPTM1L (if available)
    TreeFam Gene Tree for CLPTM1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLPTM1L gene
    CLPTM12  
    1 SIMAP similar gene for CLPTM1L using alignment to 2 protein entries:     CLP1L_HUMAN (see all proteins):
    CLPTM1

    CLPTM1L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLPTM1L
    PGOHUM00000244375


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLPTM1L (see all 1143)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0427544
    A breast cancer sample4--see VAR_0427542 K N mis40--------
    rs1870050821,2
    --1317608(+) GATTGC/TGTGAA 1 -- int10--------
    rs1918331801,2
    --1317686(+) TAAACC/TTCACT 1 -- int10--------
    rs1386606811,2
    --1317695(+) CTACAC/TACCGA 1 -- int10--------
    rs1166120871,2
    F--1317699(+) ACACCG/AAGTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1836804091,2
    --1317778(+) GACCTC/GATGGG 1 -- int10--------
    rs38166591,2
    C,F--1317820(-) CATCTC/TAGTTG 1 -- int113Minor allele frequency- T:0.36MN NA WA CSA EA 768
    rs1879783291,2
    --1317834(+) CGTATC/GTAAGA 1 -- int10--------
    rs18010751,2
    C,F,A,H--1317949(+) ATATCT/CGAAAT 1 -- int137Minor allele frequency- C:0.13MN EA NA NS WA CSA 3573
    rs1417570191,2
    --1318197(+) CCCGCA/GTGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLPTM1L (1317859 - 1345214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CLPTM1L (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658912CNV Deletion23128226
    esv2729478CNV Deletion23290073
    esv2671207CNV Deletion23128226
    esv2729477CNV Deletion23290073
    esv2729479CNV Deletion23290073
    nsv820391CNV Duplication20802225
    nsv4679CNV Insertion18451855
    nsv509045CNV Insertion20534489
    esv1673870CNV Insertion17803354
    esv1331109CNV Insertion17803354

    Human Gene Mutation Database (HGMD): CLPTM1L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLPTM1L
    DNA2.0 Custom Variant and Variant Library Synthesis for CLPTM1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612585    OMIM disorders: --

    20 diseases for CLPTM1L:    
    About MalaCards
    estrogen-receptor negative breast cancer    cleft lip    germ cell cancer    lung cancer susceptibility
    lung adenocarcinoma    squamous cell carcinoma of the head and neck    basal cell carcinoma    mantle cell lymphoma
    lung cancer    breast and colorectal cancer    squamous cell carcinoma    pancreatic cancer
    adenocarcinoma    breast cancer    alzheimer's disease    pancreatitis
    melanoma    ovarian cancer    colorectal cancer    malaria


    CLPTM1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLPTM1L
    Human Genome Epidemiology (HuGE) Navigator: CLPTM1L (19 documents)

    Export disorders for CLPTM1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLPTM1L gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CLPTM1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. (PubMed id 11162647)1, 2, 3 Yamamoto K.... Ohtake Y. (Biochem. Biophys. Res. Commun. 2001)
    2. Genome-wide association study identifies three new melanoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (Nat. Genet. 2011)
    3. Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. (PubMed id 21081471)1, 4 Gago-Dominguez M....Van Den Berg D.J. (Carcinogenesis 2011)
    4. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PubMed id 20972438)1, 4 Rothman N....Chanock S.J. (Nat. Genet. 2010)
    5. Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. (PubMed id 19955392)1, 4 Wang Y....Houlston R.S. (Carcinogenesis 2010)
    6. Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. (PubMed id 20802237)1, 4 Liu Z....Wei Q. (Carcinogenesis 2010)
    7. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (PubMed id 20101243)1, 4 Petersen G.M....Chanock S.J. (Nat. Genet. 2010)
    8. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. (PubMed id 20543847)1, 4 Turnbull C.... Rahman N. (Nat. Genet. 2010)
    9. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. (PubMed id 20700438)1, 4 Hsiung C.A....Lin D. (PLoS Genet. 2010)
    10. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. (PubMed id 20548021)1, 4 Truong T....Spitz M.R. (J. Natl. Cancer Inst. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81037 HGNC: 24308 AceView: CRR9 Ensembl:ENSG00000049656 euGenes: HUgn81037
    ECgene: CLPTM1L H-InvDB: CLPTM1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLPTM1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLPTM1L gene:
    Search GeneIP for patents involving CLPTM1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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