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Aliases for CLPSL2 Gene

Aliases for CLPSL2 Gene

  • Colipase Like 2 2 3 5
  • C6orf126 3 4
  • Chromosome 6 Open Reading Frame 126 2
  • Colipase-Like Protein C6orf126 3
  • Colipase-Like Protein 2 3
  • Colipase-Like 2 2
  • DJ510O8.5 3
  • AAAL3045 3
  • UNQ3045 3

External Ids for CLPSL2 Gene

Previous HGNC Symbols for CLPSL2 Gene

  • C6orf126

Previous GeneCards Identifiers for CLPSL2 Gene

  • GC06P035745
  • GC06P035859
  • GC06P036313
  • GC06P037300
  • GC06P036831
  • GC06P036912
  • GC06P037775
  • GC06P038399
  • GC06P038989

Summaries for CLPSL2 Gene

GeneCards Summary for CLPSL2 Gene

CLPSL2 (Colipase Like 2) is a Protein Coding gene. GO annotations related to this gene include enzyme activator activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPSL2 Gene

Genomics for CLPSL2 Gene

Regulatory Elements for CLPSL2 Gene

Enhancers for CLPSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G035776 0.9 ENCODE 8.9 +0.0 44 0.7 SIN3A GLIS2 EGR1 ZNF366 ZNF263 ZNF280D USF2 ZNF398 ZFP69B RAD51 CLPS ENSG00000232909 ARMC12 FKBP5 CLPSL2 CLPSL1
GH06G035757 0.7 ENCODE 4.6 -18.9 -18852 0.6 CTCF ZNF511 CBFB REST RAD21 YY1 TEAD3 KAT8 ZSCAN5C ZNF143 CLPSL2 LOC100652794 LOC285847 ENSG00000232909
GH06G035770 0.4 ENCODE 0.4 -5.6 -5636 0.2 MAFG ENSG00000228559 LOC100652794 CLPSL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLPSL2 on UCSC Golden Path with GeneCards custom track

Promoters for CLPSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196131 6 401 SIN3A GLIS2 EGR1 ZNF366 ZNF263 USF2 ZFP69B RAD51 MTA1 GLIS1

Genomic Location for CLPSL2 Gene

Chromosome:
6
Start:
35,776,594 bp from pter
End:
35,779,552 bp from pter
Size:
2,959 bases
Orientation:
Plus strand

Genomic View for CLPSL2 Gene

Genes around CLPSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPSL2 Gene

Proteins for CLPSL2 Gene

  • Protein details for CLPSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWE3-COLL2_HUMAN
    Recommended name:
    Colipase-like protein 2
    Protein Accession:
    Q6UWE3
    Secondary Accessions:
    • B0QZ45
    • Q5T9G3

    Protein attributes for CLPSL2 Gene

    Size:
    100 amino acids
    Molecular mass:
    10812 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLPSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLPSL2 Gene

Post-translational modifications for CLPSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPSL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPSL2 Gene

Domains & Families for CLPSL2 Gene

Protein Domains for CLPSL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLPSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWE3

UniProtKB/Swiss-Prot:

COLL2_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPSL2: view

No data available for Gene Families for CLPSL2 Gene

Function for CLPSL2 Gene

Gene Ontology (GO) - Molecular Function for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

Phenotypes for CLPSL2 Gene

genes like me logo Genes that share phenotypes with CLPSL2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLPSL2 Gene

Localization for CLPSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPSL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPSL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

Pathways & Interactions for CLPSL2 Gene

SuperPathways for CLPSL2 Gene

No Data Available

Interacting Proteins for CLPSL2 Gene

Selected Interacting proteins: Q6UWE3-COLL2_HUMAN for CLPSL2 Gene via UniProtKB

Symbol External ID(s) Details
UBQLN2

Gene Ontology (GO) - Biological Process for CLPSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032094 response to food IBA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with CLPSL2: view

No data available for Pathways by source and SIGNOR curated interactions for CLPSL2 Gene

Transcripts for CLPSL2 Gene

mRNA/cDNA for CLPSL2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLPSL2 Gene

Colipase-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPSL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: -
SP2: -

Relevant External Links for CLPSL2 Gene

GeneLoc Exon Structure for
CLPSL2
ECgene alternative splicing isoforms for
CLPSL2

Expression for CLPSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLPSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPSL2 Gene

This gene is overexpressed in Pancreas (x28.6) and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CLPSL2 Gene:

CLPSL2

SOURCE GeneReport for Unigene cluster for CLPSL2 Gene:

Hs.259563
genes like me logo Genes that share expression patterns with CLPSL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPSL2 Gene

Orthologs for CLPSL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLPSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPSL2 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia CLPSL2 34 35
  • 74.46 (n)
cow
(Bos Taurus)
Mammalia CLPSL2 34
  • 74.23 (n)
mouse
(Mus musculus)
Mammalia Clpsl2 34 16 35
  • 70.27 (n)
rat
(Rattus norvegicus)
Mammalia Clpsl2 34
  • 65.02 (n)
Species where no ortholog for CLPSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPSL2 Gene

ENSEMBL:
Gene Tree for CLPSL2 (if available)
TreeFam:
Gene Tree for CLPSL2 (if available)

Paralogs for CLPSL2 Gene

No data available for Paralogs for CLPSL2 Gene

Variants for CLPSL2 Gene

Sequence variations from dbSNP and Humsavar for CLPSL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000061537 -- 35,775,395(+) TCTTA(A/G)GCGAA upstream-variant-2KB
rs1000255306 -- 35,775,654(+) TGCCT(C/G)CCCCG upstream-variant-2KB
rs1001672311 -- 35,777,093(+) GCTCT(C/T)CCCTT intron-variant
rs1001767047 -- 35,777,315(+) GGGGG(A/G)GGAAC intron-variant
rs1001824197 -- 35,776,232(+) TGAGG(C/G/T)AGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLPSL2 Gene

Variant ID Type Subtype PubMed ID
esv2759420 CNV gain 17122850
esv2762585 CNV gain 21179565
esv3608689 CNV gain 21293372
esv3890842 CNV gain 25118596
nsv428143 CNV gain 18775914
nsv524941 CNV loss 19592680
nsv525686 CNV gain 19592680
nsv602924 CNV gain 21841781
nsv7891 CNV gain 18304495
nsv821646 CNV loss 15273396

Variation tolerance for CLPSL2 Gene

Gene Damage Index Score: 5.92; 74.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLPSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPSL2 Gene

Disorders for CLPSL2 Gene

Relevant External Links for CLPSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPSL2

No disorders were found for CLPSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLPSL2 Gene

Publications for CLPSL2 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for CLPSL2 Gene

Sources for CLPSL2 Gene

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