CLPSL2 Gene
protein-coding GIFtS: 34
GCID: GC06P035859
|
|
colipase-like 2(Previous name: chromosome 6 open reading frame 126 )
(Previous symbol: C6orf126)
| |
Aliases
for CLPSL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Colipase-Like 21 2 | | Chromosome 6 Open Reading Frame 1261 | | C6orf1261 2 3 | | AAAL30452 | | UNQ30451 2 | | Colipase-Like Protein 22 | | DJ510O8.51 | | Colipase-Like Protein C6orf1262 |
Export aliases for CLPSL2 gene to outside databasesPrevious GC identifer: GC06P035745 |
Summaries
for CLPSL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CLPSL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CLPSL2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLPSL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPSL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31CLPSL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P035859: view genomic region
(about GC identifiers)
Start:
|
35,744,371 bp from pter |
End:
|
35,747,329 bp from pter |
Size:
|
2,959 bases |
Orientation:
|
plus strand |
|
Proteins
for CLPSL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COLL2_HUMAN, Q6UWE3 (See
protein sequence)Recommended Name: Colipase-like protein 2 precursor Size: 100 amino acids; 10812 Da
Subcellular location: Secreted (Probable)
Secondary accessions: B0QZ45 Q5T9G3Alternative splicing: 2 isoforms: Q6UWE3-1 Q6UWE3-2 (Ref.1 (AAQ89182) sequence is in conflict in position: 79:R->C)Explore the universe of human proteins at neXtProt for CLPSL2: NX_Q6UWE3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWE3
CLPSL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997292.2
ENSEMBL proteins: ENSP00000353639 ENSP00000385898
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CLPSL2 for ontologies About GeneDecksing
CLPSL2 Antibody Products:
Assay Products for CLPSL2: |
Protein
Domains /
Families
for CLPSL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLPSL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UWE3ProtoNet protein and cluster: Q6UWE3 UniProtKB/Swiss-Prot: COLL2_HUMAN, Q6UWE3Similarity: Belongs to the colipase family |
Function
for CLPSL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CLPSL2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLPSL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPSL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008047 | enzyme activator activity |
IEA | -- |
CLPSL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CLPSL2:
|
Pathways & Interactions
for CLPSL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLPSL2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007586 | digestion |
IEA | -- | | GO:0016042 | lipid catabolic process |
IEA | -- |
CLPSL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLPSL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLPSL2
Search CenterWatch for drugs/clinical trials and news about CLPSL2 / COLL2
|
Transcripts
for CLPSL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLPSL2 gene: NM_207409.2 Unigene Cluster for CLPSL2: Colipase-like 2 Hs.259563 [show with all ESTs]Unigene Representative Sequence: CD5138224 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481904 ENST00000360454(uc010jvz.1 uc003olc.1) ENST00000403376
ENST00000467122
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CLPSL2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLPSL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPSL2 |
Additional cDNA sequence: AY358823.1 1 DOTS entry: DT.101976154 5 AceView cDNA sequences: AY358823 NM_207409 AW665167 AA861820 CD513822
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CLPSL2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 |
|---|
|
| SP1: | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for CLPSL2
|
Expression
for CLPSL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLPSL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTGCTTGC
About this image
See CLPSL2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.259563
SABiosciences Custom PCR Arrays for CLPSL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLPSL2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CLPSL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPSL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPSL2 |
Orthologs
for CLPSL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CLPSL2 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for CLPSL2 (if available)
TreeFam Gene Tree for CLPSL2 (if available) |
Paralogs
for CLPSL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CLPSL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLPSL2 (35744371 - 35747329 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLPSL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLPSL2 |
|
Disorders
/ Diseases
for CLPSL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CLPSL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLPSL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLPSL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for CLPSL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLPSL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLPSL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLPSL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLPSL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLPSL2 gene:
Search GeneIP for patents involving CLPSL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLPSL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLPSL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLPSL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLPSL2 | | | OriGene Protein Over-expression Lysate for CLPSL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLPSL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPSL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLPSL2 | | OriGene Custom Protein Services for CLPSL2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLPSL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLPSL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPSL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPSL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPSL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPSL2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CLPSL2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CLPSL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CLPSL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPSL2 |
|
|
|
|
