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Aliases for CLPSL1 Gene

Aliases for CLPSL1 Gene

  • Colipase Like 1 2 3 5
  • C6orf127 3 4
  • Chromosome 6 Open Reading Frame 127 2
  • Colipase-Like Protein C6orf127 3
  • Colipase-Like Protein 1 3
  • Colipase-Like 1 2
  • DJ510O8.6 3
  • ESP32 3

External Ids for CLPSL1 Gene

Previous HGNC Symbols for CLPSL1 Gene

  • C6orf127

Previous GeneCards Identifiers for CLPSL1 Gene

  • GC06P035749
  • GC06P035862
  • GC06P036314
  • GC06P037301
  • GC06P036832
  • GC06P036913
  • GC06P037776
  • GC06P038400
  • GC06P038990

Summaries for CLPSL1 Gene

GeneCards Summary for CLPSL1 Gene

CLPSL1 (Colipase Like 1) is a Protein Coding gene. GO annotations related to this gene include enzyme activator activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPSL1 Gene

Genomics for CLPSL1 Gene

Regulatory Elements for CLPSL1 Gene

Enhancers for CLPSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G035776 0.9 ENCODE 0.7 -4.4 -4380 0.7 SIN3A GLIS2 EGR1 ZNF366 ZNF263 ZNF280D USF2 ZNF398 ZFP69B RAD51 CLPS ENSG00000232909 ARMC12 FKBP5 CLPSL2 CLPSL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLPSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLPSL1 Gene

Chromosome:
6
Start:
35,781,017 bp from pter
End:
35,793,675 bp from pter
Size:
12,659 bases
Orientation:
Plus strand

Genomic View for CLPSL1 Gene

Genes around CLPSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPSL1 Gene

Proteins for CLPSL1 Gene

  • Protein details for CLPSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUU4-COLL1_HUMAN
    Recommended name:
    Colipase-like protein 1
    Protein Accession:
    A2RUU4
    Secondary Accessions:
    • A7E2T6
    • B2RPE2
    • B5G4V2
    • B6ZDM9
    • Q5T9G1

    Protein attributes for CLPSL1 Gene

    Size:
    121 amino acids
    Molecular mass:
    14057 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=ABK41022.1; Type=Frameshift; Positions=120; Evidence={ECO:0000305}; Sequence=CAI21640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CLPSL1 Gene

Post-translational modifications for CLPSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPSL1 Gene

No data available for DME Specific Peptides for CLPSL1 Gene

Domains & Families for CLPSL1 Gene

Protein Domains for CLPSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLPSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2RUU4

UniProtKB/Swiss-Prot:

COLL1_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPSL1: view

No data available for Gene Families for CLPSL1 Gene

Function for CLPSL1 Gene

Gene Ontology (GO) - Molecular Function for CLPSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPSL1: view

Phenotypes for CLPSL1 Gene

GenomeRNAi human phenotypes for CLPSL1:
genes like me logo Genes that share phenotypes with CLPSL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLPSL1 Gene

Localization for CLPSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPSL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPSL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CLPSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CLPSL1: view

Pathways & Interactions for CLPSL1 Gene

SuperPathways for CLPSL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLPSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032094 response to food IBA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with CLPSL1: view

No data available for Pathways by source and SIGNOR curated interactions for CLPSL1 Gene

Drugs & Compounds for CLPSL1 Gene

No Compound Related Data Available

Transcripts for CLPSL1 Gene

mRNA/cDNA for CLPSL1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLPSL1 Gene

Colipase-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPSL1 Gene

No ASD Table

Relevant External Links for CLPSL1 Gene

GeneLoc Exon Structure for
CLPSL1
ECgene alternative splicing isoforms for
CLPSL1

Expression for CLPSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLPSL1 Gene

mRNA differential expression in normal tissues according to GTEx for CLPSL1 Gene

This gene is overexpressed in Pancreas (x50.7).

NURSA nuclear receptor signaling pathways regulating expression of CLPSL1 Gene:

CLPSL1

SOURCE GeneReport for Unigene cluster for CLPSL1 Gene:

Hs.131296

mRNA Expression by UniProt/SwissProt for CLPSL1 Gene:

A2RUU4-COLL1_HUMAN
Tissue specificity: Exclusively expressed in epididymis, in the corpus region.
genes like me logo Genes that share expression patterns with CLPSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPSL1 Gene

Orthologs for CLPSL1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLPSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPSL1 34 35
  • 97.22 (n)
Species where no ortholog for CLPSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPSL1 Gene

ENSEMBL:
Gene Tree for CLPSL1 (if available)
TreeFam:
Gene Tree for CLPSL1 (if available)

Paralogs for CLPSL1 Gene

(1) SIMAP similar genes for CLPSL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLPSL1: view

No data available for Paralogs for CLPSL1 Gene

Variants for CLPSL1 Gene

Sequence variations from dbSNP and Humsavar for CLPSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001161004 -- 35,791,462(+) AAATT(A/T)GCTGG intron-variant
rs1001330937 -- 35,791,326(+) GTTTA(A/C)TAGGC intron-variant
rs1001488096 -- 35,786,955(+) GCGGA(A/G)GGCGG intron-variant, reference, synonymous-codon
rs1001926909 -- 35,782,858(+) CGGGA(C/G)GCGGC intron-variant
rs1002467026 -- 35,784,734(+) GTCTC(-/T)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPSL1 Gene

Variant ID Type Subtype PubMed ID
dgv1043n67 CNV gain 20364138
dgv1177e214 CNV gain 21293372
dgv156e180 CNV gain 20482838
dgv3300n106 CNV duplication 24896259
dgv3488e59 CNV duplication 20981092
dgv3489e59 CNV duplication 20981092
dgv3490e59 CNV tandem duplication 20981092
esv25108 CNV gain 19812545
esv2759420 CNV gain 17122850
esv2860458 CNV duplication 24192839
esv33535 CNV gain 17666407
esv3608689 CNV gain 21293372
esv3890842 CNV gain 25118596
nsv1143148 CNV tandem duplication 24896259
nsv428143 CNV gain 18775914
nsv511122 OTHER complex 20534489
nsv513737 CNV insertion 21212237
nsv525686 CNV gain 19592680
nsv5259 CNV insertion 18451855
nsv602924 CNV gain 21841781
nsv7891 CNV gain 18304495
nsv819076 CNV gain 19587683
nsv821646 CNV loss 15273396
nsv970364 CNV duplication 23825009

Variation tolerance for CLPSL1 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLPSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPSL1 Gene

Disorders for CLPSL1 Gene

Relevant External Links for CLPSL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPSL1

No disorders were found for CLPSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLPSL1 Gene

Publications for CLPSL1 Gene

  1. Transcriptome analysis of a cDNA library from adult human epididymis. (PMID: 18390568) Li J.Y. … Zhang Y.L. (DNA Res. 2008) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for CLPSL1 Gene

Sources for CLPSL1 Gene

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