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CLPSL1 Gene

protein-coding   GIFtS: 30
GCID: GC06P037301

Colipase-Like 1

(Previous name: chromosome 6 open reading frame 127)
(Previous symbol: C6orf127)
  Search for CLPSL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Colipase-Like 11 2     Colipase-Like Protein 12
C6orf1271 2 3     Colipase-Like Protein C6orf1272
Chromosome 6 Open Reading Frame 1271     dJ510O8.62
ESP322     

External Ids:    HGNC: 212511   Entrez Gene: 3402042   Ensembl: ENSG000002041407   UniProtKB: A2RUU43   

Export aliases for CLPSL1 gene to outside databases

Previous GC identifers: GC06P035749 GC06P035862 GC06P036314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLPSL1 Gene:
CLPSL1 (colipase-like 1) is a protein-coding gene. GO annotations related to this gene include enzyme activator activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CLPSL1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CLPSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLPSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

CLPSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPSL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037301:  view genomic region     (about GC identifiers)

Start:
35,748,794 bp from pter      End:
35,761,452 bp from pter
Size:
12,659 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COLL1_HUMAN, A2RUU4 (See protein sequence)
Recommended Name: Colipase-like protein 1 precursor  
Size: 121 amino acids; 14057 Da
Sequence caution: Sequence=ABK41022.1; Type=Frameshift; Positions=120; Sequence=CAI21640.1; Type=Erroneous gene
model prediction;
Secondary accessions: A7E2T6 B2RPE2 B5G4V2 B6ZDM9 Q5T9G1

Explore the universe of human proteins at neXtProt for CLPSL1: NX_A2RUU4

Explore proteomics data for CLPSL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLPSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010886.1  
    ENSEMBL proteins: 
     ENSP00000362968   ENSP00000396556   ENSP00000438478  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001981 Colipase

    Graphical View of Domain Structure for InterPro Entry A2RUU4

    ProtoNet protein and cluster: A2RUU4

    UniProtKB/Swiss-Prot: COLL1_HUMAN, A2RUU4
    Similarity: Belongs to the colipase family


    CLPSL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008047enzyme activator activity IEA--
         
    CLPSL1 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COLL1_HUMAN, A2RUU4: Secreted (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CLPSL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLPSL1
    Interactions:

        Search GeneGlobe Interaction Network for CLPSL1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007586digestion IEA--
    GO:0016042lipid catabolic process IEA--

    CLPSL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLPSL1 (COLL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLPSL1 gene: 
    NM_001010886.3  

    Unigene Cluster for CLPSL1:

    Colipase-like 1
    Hs.131296  [show with all ESTs]
    Unigene Representative Sequence: EH041839
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373861 ENST00000428710 ENST00000542261(uc003old.4)
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    Additional mRNA sequence: 

    BC127735.1 BC133046.1 BC137392.1 BC150543.1 BC150544.1 DQ823638.1 

    1 DOTS entry:

    DT.40128741 

    3 AceView cDNA sequences:

    BX106742 AI018488 BF509739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLPSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLPSL1 Expression
    About this image

    CLPSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLPSL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131296

    UniProtKB/Swiss-Prot: COLL1_HUMAN, A2RUU4
    Tissue specificity: Exclusively expressed in epididymis, in the corpus region

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for CLPSL1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia CLPSL11 colipase-like 1 97.22(n)
    95.83(a)
      747681  XM_001172513.3  XP_001172513.1 


    ENSEMBL Gene Tree for CLPSL1 (if available)
    TreeFam Gene Tree for CLPSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLPSL1 gene
    1 SIMAP similar gene for CLPSL1 using alignment to 3 protein entries:     COLL1_HUMAN (see all proteins):
    CLPS

    CLPSL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLPSL1 (see all 229)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470456061,2
    --35747887(+) CTGCTC/GCAAGT 1 -- us2k10--------
    rs1902558101,2
    --35747938(+) ATTTAC/TTGGTG 1 -- us2k10--------
    rs1829791511,2
    --35748079(+) CACTTC/GCTATG 1 -- us2k10--------
    rs77533221,2
    C,F,A,H--35748086(+) tatgtG/Tccaga 1 -- us2k1 tfbs327Minor allele frequency- N:0.00NS EA NA WA CSA 2725
    rs1888158851,2
    --35748165(+) TGGCTC/TGATCG 1 -- us2k10--------
    rs121949641,2
    C--35748166(+) ggctcG/Aatcgc 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1382737701,2
    --35748209(+) AAGATC/TCTCCC 1 -- us2k10--------
    rs13267571,2
    C,F,A--35748253(+) gtgtgC/Acacca 1 -- us2k18Minor allele frequency- A:0.46NA WA CSA EA 250
    rs2010406331,2
    --35748270(+) GCCAA-/TTTTTT 1 -- us2k10--------
    rs715401211,2
    C--35748291(+) TTTTCTTT/-TTTTT 2 -- us2k1 cds11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for CLPSL1 (35748794 - 35761452 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLPSL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLPSL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLPSL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLPSL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CLPSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptome analysis of a cDNA library from adult human epididymis. (PubMed id 18390568)1, 2 Li J.Y.... Zhang Y.L. (DNA Res. 2008)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340204 HGNC: 21251 AceView: LOC340204 Ensembl:ENSG00000204140 euGenes: HUgn340204
    ECgene: CLPSL1 H-InvDB: CLPSL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLPSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLPSL1 gene:
    Search GeneIP for patents involving CLPSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPSL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLPSL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLPSL1
     Search LSBio for Antibodies for CLPSL1
    Customized transgenic rodents for:
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