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Aliases for CLPS Gene

Aliases for CLPS Gene

  • Colipase, Pancreatic 2 3
  • Pancreatic Colipase Preproprotein 3
  • Colipase 3

External Ids for CLPS Gene

Summaries for CLPS Gene

Entrez Gene Summary for CLPS Gene

  • The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CLPS Gene

CLPS (Colipase, Pancreatic) is a Protein Coding gene. Diseases associated with CLPS include obsessive-compulsive personality disorder and johanson-blizzard syndrome. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot for CLPS Gene

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase

  • Enterostatin has a biological activity as a satiety signal

Gene Wiki entry for CLPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPS Gene

Genomics for CLPS Gene

Genomic Location for CLPS Gene

Start:
35,794,982 bp from pter
End:
35,797,344 bp from pter
Size:
2,363 bases
Orientation:
Minus strand

Genomic View for CLPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPS Gene

Regulatory Elements for CLPS Gene

Proteins for CLPS Gene

  • Protein details for CLPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04118-COL_HUMAN
    Recommended name:
    Colipase
    Protein Accession:
    P04118
    Secondary Accessions:
    • Q5T9G7
    • Q5U809

    Protein attributes for CLPS Gene

    Size:
    112 amino acids
    Molecular mass:
    11954 Da
    Quaternary structure:
    • Forms a 1:1 stoichiometric complex with pancreatic lipase

neXtProt entry for CLPS Gene

Proteomics data for CLPS Gene at MOPED

Post-translational modifications for CLPS Gene

No Post-translational modifications

Other Protein References for CLPS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CLPS Gene

Domains for CLPS Gene

Protein Domains for CLPS Gene

UniProtKB/Swiss-Prot:

COL_HUMAN
Family:
  • Belongs to the colipase family.:
    • P04118
genes like me logo Genes that share domains with CLPS: view

No data available for Gene Families for CLPS Gene

Function for CLPS Gene

Molecular function for CLPS Gene

GENATLAS Biochemistry: colipase,pancreatic
UniProtKB/Swiss-Prot Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
UniProtKB/Swiss-Prot Function: Enterostatin has a biological activity as a satiety signal

Gene Ontology (GO) - Molecular Function for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPS: view
genes like me logo Genes that share phenotypes with CLPS: view

Animal Models for CLPS Gene

MGI Knock Outs for CLPS:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLPS Gene

Localization for CLPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLPS Gene COMPARTMENTS Subcellular localization image for CLPS gene
Compartment Confidence
extracellular 5
chloroplast 1
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLPS: view

Pathways for CLPS Gene

genes like me logo Genes that share pathways with CLPS: view

Pathways by source for CLPS Gene

Gene Ontology (GO) - Biological Process for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process NAS 2045105
GO:0007586 digestion --
GO:0007603 phototransduction, visible light TAS --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with CLPS: view

Compounds for CLPS Gene

(2) Drugbank Compounds for CLPS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(Hydroxyethyloxy)Tri(Ethyloxy)Octane
target
METHOXYUNDECYLPHOSPHINIC ACID
target

(18) Novoseek inferred chemical compound relationships for CLPS Gene

Compound -log(P) Hits PubMed IDs
enterostatin 85.4 6
sodium taurodeoxycholate 73.6 2
taurodeoxycholate 64.9 3
deoxycholic acid 55.4 4
glycocholate 50.1 1
genes like me logo Genes that share compounds with CLPS: view

Transcripts for CLPS Gene

Unigene Clusters for CLPS Gene

Colipase, pancreatic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for CLPS Gene

GeneLoc Exon Structure for
CLPS
ECgene alternative splicing isoforms for
CLPS

Expression for CLPS Gene

mRNA expression in normal human tissues for CLPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPS Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CLPS Gene

SOURCE GeneReport for Unigene cluster for CLPS Gene Hs.1340

mRNA Expression by UniProt/SwissProt for CLPS Gene

P04118-COL_HUMAN
Tissue specificity: Expressed by the pancreas
genes like me logo Genes that share expressions with CLPS: view

Orthologs for CLPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPS 36
  • 99.7 (n)
  • 100 (a)
CLPS 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLPS 36
  • 81.85 (n)
  • 75 (a)
CLPS 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLPS 36
  • 85.12 (n)
  • 78.57 (a)
CLPS 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clps 36
  • 81.25 (n)
  • 75.89 (a)
Clps 16
Clps 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLPS 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clps 36
  • 80 (n)
  • 72.73 (a)
chicken
(Gallus gallus)
Aves CLPS 36
  • 70.92 (n)
  • 57.84 (a)
CLPS 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLPS 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clps 36
  • 56.92 (n)
  • 50.94 (a)
Species with no ortholog for CLPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPS Gene

ENSEMBL:
Gene Tree for CLPS (if available)
TreeFam:
Gene Tree for CLPS (if available)

Paralogs for CLPS Gene

Selected SIMAP similar genes for CLPS Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLPS: view

No data available for Paralogs for CLPS Gene

Variants for CLPS Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLPS Gene

P04118-COL_HUMAN
Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes

Sequence variations from dbSNP and Humsavar for CLPS Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs762583 -- 35,796,996(-) ACTGG(A/C)GAATG intron-variant
rs762584 -- 35,796,976(-) AGCAG(C/T)CCAAC intron-variant
rs1803299 -- 35,795,204(-) CGTGG(G/T)CTCCA reference, missense
rs2766594 -- 35,796,763(+) ACCCT(A/G)TTTCT intron-variant
rs2766595 -- 35,796,793(+) GCTGA(A/G)CGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLPS Gene

Variant ID Type Subtype PubMed ID
dgv1940e1 CNV Complex 17122850
nsv821646 CNV Loss 15273396
dgv6834n71 CNV Gain 21882294
dgv1941e1 CNV Complex 17122850
nsv428143 CNV Gain 18775914
nsv885805 CNV Loss 21882294
nsv7891 CNV Gain 18304495
esv33535 CNV Gain 17666407
nsv819076 CNV Gain 19587683
nsv5259 CNV Insertion 18451855
nsv511122 CNV Complex 20534489
esv259632 OTHER Complex 20981092
esv259851 OTHER Complex 20981092
esv25108 CNV Gain 19812545
dgv1043n67 CNV Gain 20364138
nsv513737 CNV Insertion 21212237
dgv156e180 CNV Gain 20482838
esv990474 CNV Insertion 20482838

Relevant External Links for CLPS Gene

HapMap Linkage Disequilibrium report
CLPS
Human Gene Mutation Database (HGMD)
CLPS

Disorders for CLPS Gene

(5) Novoseek inferred disease relationships for CLPS Gene

Disease -log(P) Hits PubMed IDs
pancreatic insufficiency 63.2 1
pancreatic diseases 57.5 1
pancreas exocrine 49.6 2
acute pancreatitis 1.59 1
obesity 0 3

Relevant External Links for CLPS

Genetic Association Database (GAD)
CLPS
Human Genome Epidemiology (HuGE) Navigator
CLPS
genes like me logo Genes that share disorders with CLPS: view

No data available for UniProtKB/Swiss-Prot for CLPS Gene

Publications for CLPS Gene

  1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PMID: 16189801) Lindner I. … Schrezenmeir J. (Mol. Nutr. Food Res. 2005) 3 4 23 49
  2. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PMID: 2045105) Davis R.C. … Lusis A.J. (Genomics 1991) 2 3 23
  3. The human colipase gene: isolation, chromosomal location, and tissue- specific expression. (PMID: 1643046) Sims H.F. … Lowe M.E. (Biochemistry 1992) 3 4 23
  4. Cloning and characterization of the human colipase cDNA. (PMID: 2337598) Lowe M.E. … Strauss A.W. (Biochemistry 1990) 3 4 23
  5. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. (PMID: 18726866) Weyrich P. … HAoring H.U. (Exp. Clin. Endocrinol. Diabetes 2009) 3 23 49

Products for CLPS Gene

Sources for CLPS Gene

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