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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLPS Gene

protein-coding GIFtS: 61
GCID: GC06M035765

colipase, pancreatic

Explore 13 diseases affiliated with
CLPS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Colipase, Pancreatic¹ ²
Colipase¹
Pancreatic Colipase Preproprotein²

External Ids:	HGNC: 2085¹	Entrez Gene: 1208²	Ensembl: ENSG00000137392⁷	OMIM: 120105⁵	UniProtKB: P04118³

Export aliases for CLPS gene to outside databases

Previous GC identifers: GC06M035764 GC06M035809 GC06M035870 GC06M035480

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLPS:

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It

binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably

increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface

of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed

in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: COL_HUMAN, P04118

Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water

interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase

Function: Enterostatin has a biological activity as a satiety signal

Gene Wiki entry for CLPS (Colipase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLPS gene promoter:
NF-1 RP58 NRSF form 1 NRSF form 2 NF-kappaB GATA-1 Ik-2 NF-kappaB1 MRF-2 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLPS promoter sequence

Search SABiosciences Chromatin IP Primers for CLPS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31

CLPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPS gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M035765: view genomic region (about GC identifiers)

Start:	35,762,759 bp from pter	End:	35,765,102 bp from pter
Size:	2,344 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COL_HUMAN, P04118 (See protein sequence)

Recommended Name: Colipase precursor

Size: 112 amino acids; 11954 Da

Subunit: Forms a 1:1 stoichiometric complex with pancreatic lipase

Subcellular location: Secreted

Secondary accessions: Q5T9G7 Q5U809

Explore the universe of human proteins at neXtProt for CLPS: NX_P04118

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04118

CLPS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001239526.1 NP_001239527.1 NP_001823.1

ENSEMBL proteins:

ENSP00000259938

Reactome Protein details: P04118
Human Recombinant Protein Products for CLPS:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for CLPS

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

CLPS for ontologies About GeneDecksing

CLPS Antibody Products:

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Assay Products for CLPS:

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	Uscn ELISAs and CLIAs for CLPS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLPS for domains About GeneDecksing

4 InterPro domains/families:

IPR017915 Colipase_CS

IPR017913 Colipase_N

IPR017914 Colipase_C

IPR001981 Colipase

Graphical View of Domain Structure for InterPro Entry P04118

ProtoNet protein and cluster: P04118

1 Blocks protein family: IPB001981 Colipase

UniProtKB/Swiss-Prot: COL_HUMAN, P04118

Similarity: Belongs to the colipase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COL_HUMAN, P04118

Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water

interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase

Function: Enterostatin has a biological activity as a satiety signal

Genatlas biochemistry entry for CLPS:

colipase,pancreatic

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008047	enzyme activator activity	IEA	--

CLPS for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Clps):

adipose tissue	behavior/neurological	craniofacial	digestive/alimentary	growth/size
homeostasis/metabolism	integument	mortality/aging

CLPS for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Clps^tm1Lowe for CLPS

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLPS

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPS
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CLPS:
		hsa-miR-1286
		SwitchGear 3'UTR luciferase reporter plasmid: CLPS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLPS (see all 7) OriGene shRNA RFP: CLPS OriGene siRNA: CLPS
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CLPS

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CLPS
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPS OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLPS
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		Sirion Biotech Customized stable knockdown cell line services for CLPS Sirion Biotech Customized inducible knockdown cell line services for CLPS Sirion Biotech Customized stable overexpressing cell line services for CLPS Sirion Biotech Customized inducible overexpressing cell line services for CLPS

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CLPS

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Digestion of dietary lipid

Digestion of dietary lipid

1.00

Disease

Disease

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 Reactome Pathways for CLPS (see all 9)

	Diseases associated with visual transduction
	Metabolism
	Visual phototransduction
	Disease
	Retinoid metabolism and transport

1 Kegg Pathway (Kegg details for CLPS):

Fat digestion and absorption

CLPS for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CLPS

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for CLPS (P04118³ ENSP00000259938⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PNLIP	P16233³, ENSP00000358223⁴	I2D: score=2 STRING: ENSP00000358223
LIPF	P07098³, ENSP00000238983⁴	I2D: score=1 STRING: ENSP00000238983
PNLIPRP2	P54317³	I2D: score=1
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
PNLIPRP1	ENSP00000351695⁴	STRING: ENSP00000351695

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001523	retinoid metabolic process	TAS	--
GO:0006629	lipid metabolic process	TAS	--
GO:0008202	steroid metabolic process	TAS	--
GO:0009791	post-embryonic development	--	--
GO:0016042	lipid catabolic process	IEA	--

CLPS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLPS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLPS

2 DrugBank Compounds for CLPS About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	--	--	target	--	10592235
METHOXYUNDECYLPHOSPHINIC ACID	--	--	target	--	10592235

10/18 Novoseek chemical compound relationships for CLPS gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
enterostatin	85.4	11	18726866 (2), 7741534 (1), 8968611 (1), 10997653 (1) (see all 5)
sodium taurodeoxycholate	73.6	2	11412003 (1), 10220337 (1)
taurodeoxycholate	64.9	3	9720253 (1), 2380637 (1), 16431912 (1)
deoxycholic acid	55.4	4	7601150 (1), 1541002 (1), 7998671 (1), 1892348 (1)
glycocholate	50.1	1	7998671 (1)
triacylglycerol	48.8	4	8315552 (2), 9254602 (1), 11721001 (1)
lipid	47.3	44	9254602 (7), 18506778 (5), 18052211 (4), 19548271 (3) (see all 17)
phosphatidylcholine	46.1	16	11721001 (6), 9254602 (4), 11099795 (2), 9622488 (1) (see all 5)
orlistat	40	2	12270672 (1)
fatty acid	34.9	13	9622488 (4), 9254602 (3), 11721001 (1)

Search CenterWatch for drugs/clinical trials and news about CLPS / COL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLPS gene (3 alternative transcripts):

NM_001252597.1 NM_001252598.1 NM_001832.3

Unigene Cluster for CLPS:

Colipase, pancreatic

Hs.1340 [show with all ESTs]

Unigene Representative Sequence: BC025693

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000259938(uc021yyz.1 uc003olf.2 uc003ole.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPS
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CLPS:
		hsa-miR-1286
		SwitchGear 3'UTR luciferase reporter plasmid: CLPS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLPS (see all 7) OriGene shRNA RFP: CLPS OriGene siRNA: CLPS
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CLPS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPS OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPS

Additional cDNA sequence:

AY780648.1 AY780649.1 BC007061.1 BC017897.1 BC025693.1 BC043489.1 BT006812.1 J02883.1

7 DOTS entries:

DT.446096 DT.100036004 DT.95206682 DT.100036003 DT.447907 DT.97803166 DT.97861325

24/109 AceView cDNA sequences (see all 109):

AA366383 BU071734 BM091386 BM509140 BQ271658 BI962548 BI711285 BM314562

CA848891 AA363723 BF507781 BM352615 BM352919 CA848416 CA849070 CA848137

NM_001832 BM565515 BM314252 BU789858 J02883 BM507247 BM509368 AI366744

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CLPS About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d
SP1:					-		-
SP2:							-
SP3:					-		-		-
SP4:

ECgene alternative splicing isoforms for CLPS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGCTGGACG

About this image

CLPS expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLPS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLPS

SOURCE GeneReport for Unigene cluster: Hs.1340

UniProtKB/Swiss-Prot: COL_HUMAN, P04118

Tissue specificity: Expressed by the pancreas

SABiosciences Expression via Pathway-Focused PCR Array including CLPS:

Obesity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPS

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CLPS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CLPS gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Clps^{1 , 5}	colipase, pancreatic^{1, 5}	81.25(n)¹ 75.89(a)¹		17 (14.76 cM)⁵ 109791¹ NM_025469.2¹ NP_079745.1¹ 28558210⁵
chicken (Gallus gallus)	Aves	CLPS¹	colipase, pancreatic	70.92(n) 57.84(a)		771102 NM_001145491.1 NP_001138963.1
lizard (Anolis carolinensis)	Reptilia	CLPS⁶	--	63(a)	1 ↔ 1	GL343382.1(745638-745781)

ENSEMBL Gene Tree for CLPS (if available)
TreeFam Gene Tree for CLPS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: COL_HUMAN, P04118

Polymorphism: Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10633959^1,2	C	--	35762333(+)	`CTAGCTG/-TGTCA`	3	--	ds500¹		1		CSA	2
rs7762515^1,2	C,F,A,H	--	35762372(+)	`TGAGAG/TCCCAG`	3	--	ds500¹		6		NS EA NA	416
rs2817014^1,2	C,F,H	--	35762380(+)	`CAGGAC/TTCTGA`	3	--	ds500¹		11		EA NA WA CSA	557
rs2817015^1,2	C,F	--	35762432(+)	`CTTACC/TCACAA`	3	--	ds500¹		3		NA	6
rs71540122^1,2	C	--	35762438(+)	`CACAAGTGTGTG TGTGT/-GTGTG`	3	--	ds500¹		1		NA	2
rs9462119^1,2	C,A,H	--	35762472(+)	`tgtgtA/GtgtgC`	3	--	ds500¹		0	--	--	--	--
rs56377606^1,2	C	--	35762475(+)	`GTATGC/TGCGCG`	3	--	ds500¹		0	--	--	--	--
rs146926463^1,2		--	35762475(+)	`TATGT-/GCGC GCGCG`	3	--	ds500¹		0	--	--	--	--
rs199652908^1,2		--	35762552(+)	`GTGAC-/TTCTCC`	3	--	ds500¹		0	--	--	--	--
rs7744781^1,2	C,F,A,H	--	35762577(+)	`TTTCCT/CAGGCT`	3	--	ds500¹		9		WA NA CSA EA	373

HapMap Linkage Disequilibrium report for CLPS (35762759 - 35765102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for CLPS
14 CNVs: 36522 81374 36524 59336 81373 36521 31285 36523 7575 3607 69488 81375 0286 93676
Human Gene Mutation Database (HGMD): CLPS

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLPS

DNA2.0 Custom Variant and Variant Library Synthesis for CLPS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLPS for disorders           About GeneDecksing

OMIM gene information: 120105    OMIM disorders: --

13 diseases for CLPS:    About MalaCards

pancreatitis johanson-blizzard syndrome exocrine pancreatic insufficiency type 2 diabetes mellitus

diabetes mellitus steatorrhea acute pancreatitis cystic fibrosis

pancreatic diseases duodenitis fibrosis cholesterol

alcoholism

5 diseases from the University of Copenhagen DISEASES database for CLPS:

Steatorrhea Borderline personality disorder Pancreatitis obsessive-compulsive personality disorder

Orofaciodigital syndrome

5 Novoseek disease relationships for CLPS gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic insufficiency	63.2	1	11102539 (1)
pancreatic diseases	57.5	1	1561522 (1)
pancreas exocrine	49.6	5	18726866 (1), 17395356 (1)
acute pancreatitis	1.59	1	8945483 (1)
obesity	0	4	20054203 (2), 18726866 (1)

Genetic Association Database (GAD): CLPS
Human Genome Epidemiology (HuGE) Navigator: CLPS (3 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CLPS gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with CLPS)

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Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PubMed id 16189801)^{1, 2, 4, 9} Lindner I.... Schrezenmeir J. (2005)
Cloning and characterization of the human colipase cDNA. (PubMed id 2337598)^{1, 2, 9} Lowe M.E.... Strauss A.W. (1990)
The human colipase gene: isolation, chromosomal location, and tissue- specific expression. (PubMed id 1643046)^{1, 2, 9} Sims H.F. and Lowe M.E. (1992)
Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PubMed id 2045105)^{1, 3, 9} Davis R.C....Lusis A.J. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. (PubMed id 8479519)^{1, 2} van Tilbeurgh H....Cambillau C. (1993)
The primary sequence of human pancreatic colipase. (PubMed id 6691986)^{1, 2} Sternby B....Borgstroem B. (1984)
Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. (PubMed id 11278590)^{1, 9} Crandall W.V. and Lowe M.E. (2001)
Genetic Variability of Procolipase Associates with Altered Insulin Secretion in Non-diabetic Caucasians. (PubMed id 18726866)^{1, 9} Weyrich P....Haring H.U. (2008)
Regulation of lipases by lipid-lipid interactions: implications for lipid-mediated signaling in cells. (PubMed id 12598038)^{1, 9} Sugar I.P....Brockman H.L. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1208	HGNC: 2085	AceView: CLPS	Ensembl:ENSG00000137392	euGenes: HUgn1208
ECgene: CLPS	Kegg: 1208	H-InvDB: CLPS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CLPS	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Colipase

Intellectual Property for CLPS gene
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Patent Information for CLPS gene:
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