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Aliases for CLPS Gene

Aliases for CLPS Gene

  • Colipase, Pancreatic 2 3

External Ids for CLPS Gene

Previous GeneCards Identifiers for CLPS Gene

  • GC06M035764
  • GC06M035809
  • GC06M035870
  • GC06M035480
  • GC06M035765
  • GC06M035867
  • GC06M035927

Summaries for CLPS Gene

Entrez Gene Summary for CLPS Gene

  • The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CLPS Gene

CLPS (Colipase, Pancreatic) is a Protein Coding gene. Diseases associated with CLPS include orofaciodigital syndrome i and obsessive-compulsive personality disorder. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot for CLPS Gene

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase

  • Enterostatin has a biological activity as a satiety signal

Gene Wiki entry for CLPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPS Gene

Genomics for CLPS Gene

Regulatory Elements for CLPS Gene

Genomic Location for CLPS Gene

Chromosome:
6
Start:
35,794,982 bp from pter
End:
35,797,344 bp from pter
Size:
2,363 bases
Orientation:
Minus strand

Genomic View for CLPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPS Gene

Proteins for CLPS Gene

  • Protein details for CLPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04118-COL_HUMAN
    Recommended name:
    Colipase
    Protein Accession:
    P04118
    Secondary Accessions:
    • Q5T9G7
    • Q5U809

    Protein attributes for CLPS Gene

    Size:
    112 amino acids
    Molecular mass:
    11954 Da
    Quaternary structure:
    • Forms a 1:1 stoichiometric complex with pancreatic lipase

neXtProt entry for CLPS Gene

Proteomics data for CLPS Gene at MOPED

Post-translational modifications for CLPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPS Gene

Antibody Products

No data available for DME Specific Peptides for CLPS Gene

Domains & Families for CLPS Gene

Protein Domains for CLPS Gene

Suggested Antigen Peptide Sequences for CLPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04118

UniProtKB/Swiss-Prot:

COL_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPS: view

No data available for Gene Families for CLPS Gene

Function for CLPS Gene

Molecular function for CLPS Gene

GENATLAS Biochemistry:
colipase,pancreatic
UniProtKB/Swiss-Prot Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
UniProtKB/Swiss-Prot Function:
Enterostatin has a biological activity as a satiety signal

Gene Ontology (GO) - Molecular Function for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPS: view
genes like me logo Genes that share phenotypes with CLPS: view

Animal Models for CLPS Gene

MGI Knock Outs for CLPS:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLPS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CLPS Gene

Localization for CLPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLPS Gene COMPARTMENTS Subcellular localization image for CLPS gene
Compartment Confidence
extracellular 5
chloroplast 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLPS: view

Pathways & Interactions for CLPS Gene

genes like me logo Genes that share pathways with CLPS: view

Pathways by source for CLPS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process NAS 2045105
GO:0007586 digestion --
GO:0007603 phototransduction, visible light TAS --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with CLPS: view

No data available for SIGNOR curated interactions for CLPS Gene

Drugs & Compounds for CLPS Gene

(7) Drugs for CLPS Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
deoxycholic acid Approved Pharma Antagonist 40
Orlistat Approved, Investigational Pharma Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 49
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0
METHOXYUNDECYLPHOSPHINIC ACID Experimental Pharma Target 0
cholesterol Experimental Pharma Agonist 0

(13) Additional Compounds for CLPS Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
aspartate
cacl2
Enterostatin
117830-79-2
Fatty acid
glycocholate
genes like me logo Genes that share compounds with CLPS: view

Transcripts for CLPS Gene

Unigene Clusters for CLPS Gene

Colipase, pancreatic:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLPS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for CLPS Gene

GeneLoc Exon Structure for
CLPS
ECgene alternative splicing isoforms for
CLPS

Expression for CLPS Gene

mRNA expression in normal human tissues for CLPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPS Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CLPS Gene

This gene is overexpressed in Pancreatic juice (56.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLPS Gene



SOURCE GeneReport for Unigene cluster for CLPS Gene Hs.1340

mRNA Expression by UniProt/SwissProt for CLPS Gene

P04118-COL_HUMAN
Tissue specificity: Expressed by the pancreas
genes like me logo Genes that share expression patterns with CLPS: view

Protein tissue co-expression partners for CLPS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLPS 35
  • 81.85 (n)
  • 75 (a)
CLPS 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLPS 35
  • 85.12 (n)
  • 78.57 (a)
CLPS 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clps 35
  • 81.25 (n)
  • 75.89 (a)
Clps 16
Clps 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLPS 35
  • 99.7 (n)
  • 100 (a)
CLPS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clps 35
  • 80 (n)
  • 72.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CLPS 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLPS 35
  • 70.92 (n)
  • 57.84 (a)
CLPS 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLPS 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clps 35
  • 56.92 (n)
  • 50.94 (a)
Species with no ortholog for CLPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPS Gene

ENSEMBL:
Gene Tree for CLPS (if available)
TreeFam:
Gene Tree for CLPS (if available)

Paralogs for CLPS Gene

(1) SIMAP similar genes for CLPS Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLPS: view

No data available for Paralogs for CLPS Gene

Variants for CLPS Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLPS Gene

P04118-COL_HUMAN
Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes

Sequence variations from dbSNP and Humsavar for CLPS Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1803299 -- 35,795,204(-) CGTGG(G/T)CTCCA reference, missense
rs2817014 -- 35,794,603(+) CAGGA(C/T)TCTGA downstream-variant-500B
rs2817015 -- 35,794,655(+) CTTAC(C/T)CACAA downstream-variant-500B
rs2817016 -- 35,794,842(+) TCTCC(A/C)ATCTG downstream-variant-500B
rs2817017 -- 35,794,978(+) GAGAC(C/T)GGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLPS Gene

Variant ID Type Subtype PubMed ID
dgv1940e1 CNV Complex 17122850
nsv821646 CNV Loss 15273396
dgv6834n71 CNV Gain 21882294
dgv1941e1 CNV Complex 17122850
nsv428143 CNV Gain 18775914
nsv885805 CNV Loss 21882294
nsv7891 CNV Gain 18304495
esv33535 CNV Gain 17666407
nsv819076 CNV Gain 19587683
nsv5259 CNV Insertion 18451855
nsv511122 CNV Complex 20534489
esv259632 OTHER Complex 20981092
esv259851 OTHER Complex 20981092
esv25108 CNV Gain 19812545
dgv1043n67 CNV Gain 20364138
nsv513737 CNV Insertion 21212237
dgv156e180 CNV Gain 20482838
esv990474 CNV Insertion 20482838

Variation tolerance for CLPS Gene

Residual Variation Intolerance Score: 78.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPS Gene

HapMap Linkage Disequilibrium report
CLPS
Human Gene Mutation Database (HGMD)
CLPS

Disorders for CLPS Gene

MalaCards: The human disease database

(4) MalaCards diseases for CLPS Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
orofaciodigital syndrome i
  • orofaciodigital syndrome type i
obsessive-compulsive personality disorder
  • ocpd
johanson-blizzard syndrome
  • jbs
pancreas disease
  • pancreatic diseases
- elite association
Search CLPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLPS

Genetic Association Database (GAD)
CLPS
Human Genome Epidemiology (HuGE) Navigator
CLPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPS
genes like me logo Genes that share disorders with CLPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPS Gene

Publications for CLPS Gene

  1. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PMID: 2045105) Davis R.C. … Lusis A.J. (Genomics 1991) 2 23 67
  2. Modification of pancreatic lipase properties by directed molecular evolution. (PMID: 20150178) Colin D.Y. … Kerfelec B. (Protein Eng. Des. Sel. 2010) 23 67
  3. Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics. (PMID: 20136147) Ranaldi S. … Fournel A. (Biochemistry 2010) 23 67
  4. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). (PMID: 19548271) Alves B.N. … Hudig D. (Cell Biochem. Funct. 2009) 23 67
  5. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. (PMID: 19824014) Berton A. … Crenon I. (Mol. Nutr. Food Res. 2009) 23 67

Products for CLPS Gene

Sources for CLPS Gene

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