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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLPS Gene

protein-coding   GIFtS: 61
GCID: GC06M035765

Colipase, Pancreatic

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Colipase, Pancreatic1 2
colipase2
Pancreatic Colipase Preproprotein2

External Ids:    HGNC: 20851   Entrez Gene: 12082   Ensembl: ENSG000001373927   OMIM: 1201055   UniProtKB: P041183   

Export aliases for CLPS gene to outside databases

Previous GC identifers: GC06M035764 GC06M035809 GC06M035870 GC06M035480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLPS Gene:
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis.
It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and
considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor
noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile
salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by
tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Nov 2011)

GeneCards Summary for CLPS Gene: 
CLPS (colipase, pancreatic) is a protein-coding gene. Diseases associated with CLPS include obsessive-compulsive personality disorder, and johanson-blizzard syndrome, and among its related super-pathways are Visual phototransduction and Metabolic pathways. GO annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot: COL_HUMAN, P04118
Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water
interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
Function: Enterostatin has a biological activity as a satiety signal

Gene Wiki entry for CLPS (Colipase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLPS gene promoter:
         NF-1   RP58   NRSF form 1   NRSF form 2   NF-kappaB   GATA-1   Ik-2   NF-kappaB1   MRF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPS promoter sequence
   Search SABiosciences Chromatin IP Primers for CLPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

CLPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035765:  view genomic region     (about GC identifiers)

Start:
35,762,759 bp from pter      End:
35,765,102 bp from pter
Size:
2,344 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COL_HUMAN, P04118 (See protein sequence)
Recommended Name: Colipase precursor  
Size: 112 amino acids; 11954 Da
Subunit: Forms a 1:1 stoichiometric complex with pancreatic lipase
Subcellular location: Secreted
Secondary accessions: Q5T9G7 Q5U809

Explore the universe of human proteins at neXtProt for CLPS: NX_P04118

Explore proteomics data for CLPS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04118

  • CLPS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLPS Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001239526.1  NP_001239527.1  NP_001823.1  

    ENSEMBL proteins: 
     ENSP00000259938  
    Reactome Protein details: P04118
    Human Recombinant Protein Products for CLPS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate for CLPS
    OriGene MassSpec for CLPS 
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    GenScript Custom Purified and Recombinant Proteins Services for CLPS
    Novus Biologicals CLPS Proteins
    Novus Biologicals CLPS Lysates
    Sino Biological Recombinant Protein for CLPS
    Sino Biological Cell Lysate for CLPS 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLPS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    CLPS for ontologies           About GeneDecksing



    CLPS Antibody Products: 
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    Abcam antibodies for CLPS
    Cloud-Clone Corp. Antibodies for CLPS 
    ThermoFisher Antibodies for CLPS
    Search LSBio for Antibodies for CLPS 

    Assay Products for CLPS: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLPS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLPS 
    Cloud-Clone Corp. CLIAs for CLPS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017915 Colipase_CS
     IPR017913 Colipase_N
     IPR017914 Colipase_C
     IPR001981 Colipase

    Graphical View of Domain Structure for InterPro Entry P04118

    ProtoNet protein and cluster: P04118

    1 Blocks protein domain: IPB001981 Colipase

    UniProtKB/Swiss-Prot: COL_HUMAN, P04118
    Similarity: Belongs to the colipase family


    CLPS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COL_HUMAN, P04118
    Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water
    interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
    Function: Enterostatin has a biological activity as a satiety signal

         Genatlas biochemistry entry for CLPS:
    colipase,pancreatic

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008047enzyme activator activity IEA--
         
    CLPS for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clps):
     adipose tissue  behavior/neurological  craniofacial  digestive/alimentary  growth/size 
     homeostasis/metabolism  integument  mortality/aging 

    CLPS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clpstm1Lowe for CLPS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLPS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLPS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLPS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLPS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLPS:
    hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidCLPS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPS

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CLPS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLPS (see all 6)
    OriGene ORF clones in mouse, rat for CLPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
    Sino Biological Human cDNA Clone for CLPS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS
    Sirion Biotech Customized lentivirus for stable overexpression of CLPS 
                         Customized lentivirus expression plasmids for stable overexpression of CLPS 

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    Search LifeMap BioReagents cell lines for CLPS
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLPS About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    Retinoid metabolism and transport0.48
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Lipoprotein metabolism
    Lipid digestion, mobilization, and transport0.56
    4Signaling by GPCR
    Signal Transduction0.55
    5Fat digestion and absorption
    Fat digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for CLPS (see all 9)
        Diseases associated with visual transduction
    Metabolism
    Visual phototransduction
    Disease
    Retinoid metabolism and transport


    1         Kegg Pathway  (Kegg details for CLPS):
        Fat digestion and absorption


    CLPS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for CLPS (P041183 ENSP000002599384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNLIPP162333, ENSP000003582234I2D: score=2 STRING: ENSP00000358223
    LIPFP070983, ENSP000002389834I2D: score=1 STRING: ENSP00000238983
    PNLIPRP2P543173I2D: score=1 
    CELENSP000003611514STRING: ENSP00000361151
    PNLIPRP1ENSP000003516954STRING: ENSP00000351695
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006629lipid metabolic process NAS2045105
    GO:0007586digestion ----
    GO:0007603phototransduction, visible light TAS--
    GO:0016042lipid catabolic process IEA--

    CLPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLPS (COL)

    2 DrugBank Compounds for CLPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Hydroxyethyloxy)Tri(Ethyloxy)Octane-- --target--10592235
    METHOXYUNDECYLPHOSPHINIC ACID-- --target--10592235

    10/18 Novoseek inferred chemical compound relationships for CLPS gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enterostatin 85.4 11 18726866 (2), 7741534 (1), 8968611 (1), 10997653 (1) (see all 5)
    sodium taurodeoxycholate 73.6 2 11412003 (1), 10220337 (1)
    taurodeoxycholate 64.9 3 9720253 (1), 2380637 (1), 16431912 (1)
    deoxycholic acid 55.4 4 7601150 (1), 1541002 (1), 7998671 (1), 1892348 (1)
    glycocholate 50.1 1 7998671 (1)
    triacylglycerol 48.8 4 8315552 (2), 9254602 (1), 11721001 (1)
    lipid 47.3 44 9254602 (7), 18506778 (5), 18052211 (4), 19548271 (3) (see all 17)
    phosphatidylcholine 46.1 16 11721001 (6), 9254602 (4), 11099795 (2), 9622488 (1) (see all 5)
    orlistat 40 2 12270672 (1)
    fatty acid 34.9 13 9622488 (4), 9254602 (3), 11721001 (1)

    Search CenterWatch for drugs/clinical trials and news about CLPS / COL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLPS gene (3 alternative transcripts): 
    NM_001252597.1  NM_001252598.1  NM_001832.3  

    Unigene Cluster for CLPS:

    Colipase, pancreatic
    Hs.1340  [show with all ESTs]
    Unigene Representative Sequence: BC025693
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259938(uc021yyz.1 uc003olf.2 uc003ole.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLPS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLPS:
    hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidCLPS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPS
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    OriGene ORF clones in mouse, rat for CLPS
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    GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS
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    Primer
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    OriGene qPCR primer pairs and template standards for CLPS
    OriGene qSTAR qPCR primer pairs in human, mouse for CLPS
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPS

    Additional mRNA sequence: 

    AY780648.1 AY780649.1 BC007061.1 BC017897.1 BC025693.1 BC043489.1 BT006812.1 J02883.1 

    7 DOTS entries:

    DT.446096  DT.100036004  DT.95206682  DT.100036003  DT.447907  DT.97803166  DT.97861325 

    24/109 AceView cDNA sequences (see all 109):

    BM091386 CA848137 J02883 BU789858 BM565515 BM509140 BI711285 CA849070 
    BM314252 BM507247 AA363723 BU071734 BQ271658 CA848891 BF507781 BM352919 
    BM352615 BI962548 AA366383 CA848416 NM_001832 BM314562 BU951760 AA367234 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CLPS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:              -     -                                 
    SP2:                    -                                 
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for CLPS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCTGGACG
    CLPS Expression
    About this image


    See CLPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLPS

    SOURCE GeneReport for Unigene cluster: Hs.1340

    UniProtKB/Swiss-Prot: COL_HUMAN, P04118
    Tissue specificity: Expressed by the pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including CLPS: 
              Obesity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLPS gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clps1 , 5 colipase, pancreatic1, 5 81.25(n)1
    75.89(a)1
      17 (14.76 cM)5
    1097911  NM_025469.21  NP_079745.11 
     285582105 
    chicken
    (Gallus gallus)
    Aves CLPS1 colipase, pancreatic 70.92(n)
    57.84(a)
      771102  NM_001145491.1  NP_001138963.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLPS6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343382.1(745638-745781)


    ENSEMBL Gene Tree for CLPS (if available)
    TreeFam Gene Tree for CLPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLPS gene
    1 SIMAP similar gene for CLPS using alignment to 2 protein entries:     COL_HUMAN (see all proteins):
    CLPSL1

    CLPS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: COL_HUMAN, P04118
    Polymorphism: Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes


    10/176 SNPs in CLPS are shown (see all 176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106339591,2
    C--35762333(+) CTAGCTG/-TGTCA 3 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs106430681,2
    C--35762334(+) GCTGT-/GT/TG 
            
    CATAT
    3 -- ds50010--------
    rs77625151,2
    C,F,A,H--35762372(+) TGAGAG/TCCCAG 3 -- ds50016Minor allele frequency- T:0.00NS EA NA 416
    rs28170141,2
    C,F,H--35762380(+) CAGGAC/TTCTGA 3 -- ds500111Minor allele frequency- N:0.00EA NA WA CSA 557
    rs28170151,2
    C,F--35762432(+) CTTACC/TCACAA 3 -- ds50013Minor allele frequency- T:0.33NA 6
    rs715401221,2
    C--35762438(+) CACAAGTGTGTG 
     TGTGT
    /-
    GTGTG
    3 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1132041231,2
    C--35762438(+) CACAAGTGTG   
       TGT
    /-
    GTGTG
    3 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs94621191,2
    C,A,H--35762472(+) tgtgtA/GtgtgC 3 -- ds50010--------
    rs563776061,2
    C--35762475(+) GTATGC/TGCGCG 3 -- ds50010--------
    rs1469264631,2
    --35762475(+) TATGT-/GCGC  
            
    GCGCG
    3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CLPS (35762759 - 35765102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for CLPS (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513737CNV Insertion21212237
    nsv5259CNV Insertion18451855
    esv990474CNV Insertion20482838
    nsv821646CNV Loss15273396
    nsv885805CNV Loss21882294
    nsv428143CNV Gain18775914
    dgv1043n67CNV Gain20364138
    esv33535CNV Gain17666407
    nsv819076CNV Gain19587683
    dgv6834n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): CLPS
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120105    OMIM disorders: --

    15 diseases for CLPS:    About MalaCards
    obsessive-compulsive personality disorder    johanson-blizzard syndrome    orofaciodigital syndrome    pancreatitis
    pancreatic diseases    borderline personality disorder    exocrine pancreatic insufficiency    steatorrhea
    acute pancreatitis    personality disorder    duodenitis    cystic fibrosis
    diabetes mellitus    obesity    alcoholism

    5 diseases from the University of Copenhagen DISEASES database for CLPS:
    obsessive-compulsive personality disorder     Steatorrhea     Borderline personality disorder     Pancreatitis
    Orofaciodigital syndrome

    CLPS for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CLPS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic insufficiency 63.2 1 11102539 (1)
    pancreatic diseases 57.5 1 1561522 (1)
    pancreas exocrine 49.6 5 18726866 (1), 17395356 (1)
    acute pancreatitis 1.59 1 8945483 (1)
    obesity 0 4 20054203 (2), 18726866 (1)

    Genetic Association Database (GAD): CLPS
    Human Genome Epidemiology (HuGE) Navigator: CLPS (3 documents)

    Export disorders for CLPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLPS gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with CLPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PubMed id 16189801)1, 2, 4, 9 Lindner I.... Schrezenmeir J. (2005)
    2. Cloning and characterization of the human colipase cDNA. (PubMed id 2337598)1, 2, 9 Lowe M.E.... Strauss A.W. (1990)
    3. Genetic Variability of Procolipase Associates with Altered Insulin Secretion in Non-diabetic Caucasians. (PubMed id 18726866)1, 4, 9 Weyrich P....Haring H.U. (2008)
    4. The human colipase gene: isolation, chromosomal location, and tissue- specific expression. (PubMed id 1643046)1, 2, 9 Sims H.F. and Lowe M.E. (1992)
    5. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PubMed id 2045105)1, 3, 9 Davis R.C....Lusis A.J. (1991)
    6. Procolipase gene: no association with early-onset obe sity or fat intake. (PubMed id 20054203)1, 4, 9 Wermter A.K....Hebebrand J. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. (PubMed id 8479519)1, 2 van Tilbeurgh H....Cambillau C. (1993)
    9. The primary sequence of human pancreatic colipase. (PubMed id 6691986)1, 2 Sternby B....Borgstroem B. (1984)
    10. Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. (PubMed id 11278590)1, 9 Crandall W.V. and Lowe M.E. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1208 HGNC: 2085 AceView: CLPS Ensembl:ENSG00000137392 euGenes: HUgn1208
    ECgene: CLPS Kegg: 1208 H-InvDB: CLPS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLPS Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Colipase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLPS gene:
    Search GeneIP for patents involving CLPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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