Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLPS Gene

Aliases for CLPS Gene

  • Colipase 2 3 5
  • Colipase, Pancreatic 2
  • Pancreatic Colipase 2

External Ids for CLPS Gene

Previous GeneCards Identifiers for CLPS Gene

  • GC06M035764
  • GC06M035809
  • GC06M035870
  • GC06M035480
  • GC06M035765
  • GC06M035867
  • GC06M035927
  • GC06M036109

Summaries for CLPS Gene

Entrez Gene Summary for CLPS Gene

  • The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CLPS Gene

CLPS (Colipase) is a Protein Coding gene. Diseases associated with CLPS include johanson-blizzard syndrome and obsessive-compulsive personality disorder. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot for CLPS Gene

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

  • Enterostatin has a biological activity as a satiety signal.

Gene Wiki entry for CLPS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPS Gene

Genomics for CLPS Gene

Regulatory Elements for CLPS Gene

Genomic Location for CLPS Gene

Chromosome:
6
Start:
35,794,982 bp from pter
End:
35,797,344 bp from pter
Size:
2,363 bases
Orientation:
Minus strand

Genomic View for CLPS Gene

Genes around CLPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPS Gene

Proteins for CLPS Gene

  • Protein details for CLPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04118-COL_HUMAN
    Recommended name:
    Colipase
    Protein Accession:
    P04118
    Secondary Accessions:
    • Q5T9G7
    • Q5U809

    Protein attributes for CLPS Gene

    Size:
    112 amino acids
    Molecular mass:
    11954 Da
    Quaternary structure:
    • Forms a 1:1 stoichiometric complex with pancreatic lipase.

neXtProt entry for CLPS Gene

Proteomics data for CLPS Gene at MOPED

Post-translational modifications for CLPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPS Gene

Antibody Products

No data available for DME Specific Peptides for CLPS Gene

Domains & Families for CLPS Gene

Protein Domains for CLPS Gene

Suggested Antigen Peptide Sequences for CLPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04118

UniProtKB/Swiss-Prot:

COL_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPS: view

No data available for Gene Families for CLPS Gene

Function for CLPS Gene

Molecular function for CLPS Gene

GENATLAS Biochemistry:
colipase,pancreatic
UniProtKB/Swiss-Prot Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
UniProtKB/Swiss-Prot Function:
Enterostatin has a biological activity as a satiety signal.
genes like me logo Genes that share phenotypes with CLPS: view

Animal Models for CLPS Gene

MGI Knock Outs for CLPS:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLPS Gene

Localization for CLPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLPS Gene COMPARTMENTS Subcellular localization image for CLPS gene
Compartment Confidence
extracellular 5
chloroplast 2
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CLPS Gene

Pathways & Interactions for CLPS Gene

genes like me logo Genes that share pathways with CLPS: view

Gene Ontology (GO) - Biological Process for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007603 phototransduction, visible light TAS --
GO:0009791 post-embryonic development IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032094 response to food IEA --
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with CLPS: view

No data available for SIGNOR curated interactions for CLPS Gene

Drugs & Compounds for CLPS Gene

(7) Drugs for CLPS Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0
METHOXYUNDECYLPHOSPHINIC ACID Experimental Pharma Target 0

(13) Additional Compounds for CLPS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLPS: view

Transcripts for CLPS Gene

Unigene Clusters for CLPS Gene

Colipase, pancreatic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for CLPS Gene

GeneLoc Exon Structure for
CLPS
ECgene alternative splicing isoforms for
CLPS

Expression for CLPS Gene

mRNA expression in normal human tissues for CLPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPS Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CLPS Gene

This gene is overexpressed in Pancreatic juice (56.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLPS Gene



SOURCE GeneReport for Unigene cluster for CLPS Gene Hs.1340

mRNA Expression by UniProt/SwissProt for CLPS Gene

P04118-COL_HUMAN
Tissue specificity: Expressed by the pancreas.
genes like me logo Genes that share expression patterns with CLPS: view

Protein tissue co-expression partners for CLPS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLPS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLPS 35
  • 81.85 (n)
  • 75 (a)
CLPS 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLPS 35
  • 85.12 (n)
  • 78.57 (a)
CLPS 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clps 35
  • 81.25 (n)
  • 75.89 (a)
Clps 16
Clps 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLPS 35
  • 99.7 (n)
  • 100 (a)
CLPS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clps 35
  • 80 (n)
  • 72.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CLPS 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLPS 35
  • 70.92 (n)
  • 57.84 (a)
CLPS 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLPS 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clps 35
  • 56.92 (n)
  • 50.94 (a)
Species with no ortholog for CLPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPS Gene

ENSEMBL:
Gene Tree for CLPS (if available)
TreeFam:
Gene Tree for CLPS (if available)

Paralogs for CLPS Gene

(1) SIMAP similar genes for CLPS Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLPS: view

No data available for Paralogs for CLPS Gene

Variants for CLPS Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLPS Gene

P04118-COL_HUMAN
Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

Sequence variations from dbSNP and Humsavar for CLPS Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs41270082 - 35,795,160(+) GGAGC(A/G)TCCAG reference, missense
VAR_053040 -
rs1803299 -- 35,795,204(-) CGTGG(G/T)CTCCA reference, missense
rs2817014 -- 35,794,603(+) CAGGA(C/T)TCTGA downstream-variant-500B
rs2817015 -- 35,794,655(+) CTTAC(C/T)CACAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLPS Gene

Variant ID Type Subtype PubMed ID
dgv1940e1 CNV Complex 17122850
nsv821646 CNV Loss 15273396
dgv6834n71 CNV Gain 21882294
dgv1941e1 CNV Complex 17122850
nsv428143 CNV Gain 18775914
nsv885805 CNV Loss 21882294
nsv7891 CNV Gain 18304495
esv33535 CNV Gain 17666407
nsv819076 CNV Gain 19587683
nsv5259 CNV Insertion 18451855
nsv511122 CNV Complex 20534489
esv259632 OTHER Complex 20981092
esv259851 OTHER Complex 20981092
esv25108 CNV Gain 19812545
dgv1043n67 CNV Gain 20364138
nsv513737 CNV Insertion 21212237
dgv156e180 CNV Gain 20482838
esv990474 CNV Insertion 20482838

Variation tolerance for CLPS Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLPS Gene

HapMap Linkage Disequilibrium report
CLPS
Human Gene Mutation Database (HGMD)
CLPS

Disorders for CLPS Gene

MalaCards: The human disease database

(3) MalaCards diseases for CLPS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
johanson-blizzard syndrome
  • jbs
obsessive-compulsive personality disorder
  • anankastic personality disorder
orofaciodigital syndrome i
  • orofaciodigital syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search CLPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLPS

Genetic Association Database (GAD)
CLPS
Human Genome Epidemiology (HuGE) Navigator
CLPS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLPS
genes like me logo Genes that share disorders with CLPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPS Gene

Publications for CLPS Gene

  1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PMID: 16189801) Lindner I. … Schrezenmeir J. (Mol. Nutr. Food Res. 2005) 3 4 23 48 67
  2. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PMID: 2045105) Davis R.C. … Lusis A.J. (Genomics 1991) 2 3 23
  3. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. (PMID: 18726866) Weyrich P. … HAoring H.U. (Exp. Clin. Endocrinol. Diabetes 2009) 3 23
  4. Procolipase gene: no association with early-onset obesity or fat intake. (PMID: 20054203) Wermter A.K. … Hebebrand J. (Obes Facts 2009) 3 23
  5. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. (PMID: 17715423) D'Silva S. … Lowe M.E. (J. Lipid Res. 2007) 3 23

Products for CLPS Gene

Sources for CLPS Gene

Back to Top

Content