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CLPS Gene

protein-coding   GIFtS: 61
GCID: GC06M035867

Colipase, Pancreatic

  See CLPS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Colipase, Pancreatic1 2
colipase2
Pancreatic Colipase Preproprotein2

External Ids:    HGNC: 20851   Entrez Gene: 12082   Ensembl: ENSG000001373927   OMIM: 1201055   UniProtKB: P041183   

Export aliases for CLPS gene to outside databases

Previous GC identifers: GC06M035764 GC06M035809 GC06M035870 GC06M035480 GC06M035765


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLPS Gene:
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis.
It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and
considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor
noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile
salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by
tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Nov 2011)

GeneCards Summary for CLPS Gene:
CLPS (colipase, pancreatic) is a protein-coding gene. Diseases associated with CLPS include obsessive-compulsive personality disorder, and johanson-blizzard syndrome. GO annotations related to this gene include enzyme activator activity.

UniProtKB/Swiss-Prot: COL_HUMAN, P04118
Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water
interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
Function: Enterostatin has a biological activity as a satiety signal

Gene Wiki entry for CLPS (Colipase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLPS gene promoter:
         NF-1   RP58   NRSF form 1   NRSF form 2   NF-kappaB   GATA-1   Ik-2   NF-kappaB1   MRF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPS promoter sequence
   Search Chromatin IP Primers for CLPS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

CLPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035867:  view genomic region     (about GC identifiers)

Start:
35,762,759 bp from pter      End:
35,765,102 bp from pter
Size:
2,344 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COL_HUMAN, P04118 (See protein sequence)
Recommended Name: Colipase precursor  
Size: 112 amino acids; 11954 Da
Subunit: Forms a 1:1 stoichiometric complex with pancreatic lipase
Secondary accessions: Q5T9G7 Q5U809

Explore the universe of human proteins at neXtProt for CLPS: NX_P04118

Explore proteomics data for CLPS at MOPED


See CLPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001239526.1  NP_001239527.1  NP_001823.1  

ENSEMBL proteins: 
 ENSP00000259938  
Reactome Protein details: P04118

CLPS Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for CLPS

 
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antibodies-online proteins for CLPS (12 products) 

 
antibodies-online peptides for CLPS

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antibodies-online antibodies for CLPS (41 products) 

CLPS Assay Products:

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antibodies-online kits for CLPS (16 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR017915 Colipase_CS
 IPR017913 Colipase_N
 IPR017914 Colipase_C
 IPR001981 Colipase

Graphical View of Domain Structure for InterPro Entry P04118

ProtoNet protein and cluster: P04118

1 Blocks protein domain: IPB001981 Colipase

UniProtKB/Swiss-Prot: COL_HUMAN, P04118
Similarity: Belongs to the colipase family


Find genes that share domains with CLPS           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: COL_HUMAN, P04118
Function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water
interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase
Function: Enterostatin has a biological activity as a satiety signal

     Genatlas biochemistry entry for CLPS:
colipase,pancreatic

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008047enzyme activator activity IEA--
     
Find genes that share ontologies with CLPS           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clps):
 adipose tissue  behavior/neurological  craniofacial  digestive/alimentary  growth/size/body 
 homeostasis/metabolism  integument  mortality/aging 

Find genes that share phenotypes with CLPS           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Clpstm1Lowe for CLPS

   genOway: Develop your customized and physiologically relevant rodent model for CLPS

miRNA
Products:
    
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1 qRT-PCR Assays for microRNA that regulate CLPS:
hsa-miR-1286
SwitchGear 3'UTR luciferase reporter plasmidCLPS 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CLPS
Predesigned siRNA for gene silencing in human, mouse, rat CLPS

Gene Editing
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Clone
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OriGene clones in human, mouse for CLPS (see all 6)
OriGene ORF clones in mouse, rat for CLPS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
Sino Biological Human cDNA Clone for CLPS
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
COL_HUMAN, P04118: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
chloroplast1
cytoskeleton1
nucleus1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

Find genes that share ontologies with CLPS           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CLPS About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Fat digestion and absorption
Digestion of dietary lipid0.00
Fat digestion and absorption
2Diseases associated with visual transduction
Visual phototransduction0.44
Diseases associated with visual transduction0.43
Retinoid metabolism and transport0.44
3Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
4Lipoprotein metabolism
Lipid digestion, mobilization, and transport0.59
5Signaling by GPCR
Signal Transduction0.58


Find genes that share SuperPaths with CLPS           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Reactome Pathways for CLPS
    Retinoid metabolism and transport
Digestion of dietary lipid


1 Kegg Pathway  (Kegg details for CLPS):
    Fat digestion and absorption

    Pathway & Disease-focused RT2 Profiler PCR Array including CLPS: 
          Obesity in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CLPS

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for CLPS (P041183 ENSP000002599384) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PNLIPP162333, ENSP000003582234I2D: score=2 STRING: ENSP00000358223
LIPFP070983, ENSP000002389834I2D: score=1 STRING: ENSP00000238983
PNLIPRP2P543173I2D: score=1 
CELENSP000003611514STRING: ENSP00000361151
--ENSP000003901304STRING: ENSP00000390130
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001523retinoid metabolic process TAS--
GO:0006629lipid metabolic process NAS2045105
GO:0007586digestion ----
GO:0007603phototransduction, visible light TAS--
GO:0016042lipid catabolic process IEA--

Find genes that share ontologies with CLPS           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CLPS (COL)

2 DrugBank Compounds for CLPS    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
(Hydroxyethyloxy)Tri(Ethyloxy)Octane-- --target--10592235
METHOXYUNDECYLPHOSPHINIC ACID-- --target--10592235

Selected Novoseek inferred chemical compound relationships for CLPS gene (see all 18)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
enterostatin 85.4 11 18726866 (2), 7741534 (1), 8968611 (1), 10997653 (1) (see all 5)
sodium taurodeoxycholate 73.6 2 11412003 (1), 10220337 (1)
taurodeoxycholate 64.9 3 9720253 (1), 2380637 (1), 16431912 (1)
deoxycholic acid 55.4 4 7601150 (1), 1541002 (1), 7998671 (1), 1892348 (1)
glycocholate 50.1 1 7998671 (1)
triacylglycerol 48.8 4 8315552 (2), 9254602 (1), 11721001 (1)
lipid 47.3 44 9254602 (7), 18506778 (5), 18052211 (4), 19548271 (3) (see all 17)
phosphatidylcholine 46.1 16 11721001 (6), 9254602 (4), 11099795 (2), 9622488 (1) (see all 5)
orlistat 40 2 12270672 (1)
fatty acid 34.9 13 9622488 (4), 9254602 (3), 11721001 (1)



Find genes that share compounds with CLPS           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CLPS gene (3 alternative transcripts): 
NM_001252597.1  NM_001252598.1  NM_001832.3  

Unigene Cluster for CLPS:

Colipase, pancreatic
Hs.1340  [show with all ESTs]
Unigene Representative Sequence: BC025693
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000259938(uc021yyz.1 uc003olf.2 uc003ole.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CLPS using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate CLPS:
hsa-miR-1286
SwitchGear 3'UTR luciferase reporter plasmidCLPS 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CLPS
Predesigned siRNA for gene silencing in human, mouse, rat CLPS
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GenScript: all cDNA clones in your preferred vector: CLPS (NM_001832)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPS
Primer
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OriGene qPCR primer pairs and template standards for CLPS
OriGene qSTAR qPCR primer pairs in human, mouse for CLPS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLPS
  QuantiTect SYBR Green Assays in human, mouse, rat CLPS
  QuantiFast Probe-based Assays in human, mouse, rat CLPS

Additional mRNA sequence: 

AY780648.1 AY780649.1 BC007061.1 BC017897.1 BC025693.1 BC043489.1 BT006812.1 J02883.1 

7 DOTS entries:

DT.446096  DT.100036004  DT.95206682  DT.100036003  DT.447907  DT.97803166  DT.97861325 

Selected AceView cDNA sequences (see all 109):

BU071734 CA848416 CA848891 AA366383 BM565515 BQ271658 BM091386 BI711285 
BM507247 BM314562 J02883 BM509140 BM352615 BM352919 CA849070 BU789858 
BM314252 CA848137 BI962548 AA363723 NM_001832 BF507781 BT006812 BX119030 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CLPS    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1:              -     -                                 
SP2:                    -                                 
SP3:              -     -     -                           
SP4:                                                      


ECgene alternative splicing isoforms for CLPS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CLPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACGCTGGACG
CLPS Expression
About this image


CLPS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Ovary (Reproductive System)
CLPS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CLPS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1340

UniProtKB/Swiss-Prot: COL_HUMAN, P04118
Tissue specificity: Expressed by the pancreas

    Pathway & Disease-focused RT2 Profiler PCR Array including CLPS: 
          Obesity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CLPS
OriGene qSTAR qPCR primer pairs in human, mouse for CLPS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLPS
QuantiTect SYBR Green Assays in human, mouse, rat CLPS
QuantiFast Probe-based Assays in human, mouse, rat CLPS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CLPS gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Clps1 , 5 colipase, pancreatic1, 5 81.25(n)1
75.89(a)1
  17 (14.76 cM)5
1097911  NM_025469.21  NP_079745.11 
 285582105 
chicken
(Gallus gallus)
Aves CLPS1 colipase, pancreatic 70.92(n)
57.84(a)
  771102  NM_001145491.1  NP_001138963.1 
lizard
(Anolis carolinensis)
Reptilia CLPS6
colipase, pancreatic
56(a)
1 ↔ 1
GL343382.1(745638-745781)
tropical clawed frog
(Xenopus tropicalis)
Amphibia clps1 colipase, pancreatic 56.92(n)
50.94(a)
  100135140  NM_001113855.1  NP_001107327.1 


ENSEMBL Gene Tree for CLPS (if available)
TreeFam Gene Tree for CLPS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CLPS gene
1 SIMAP similar gene for CLPS using alignment to 2 protein entries:     COL_HUMAN (see all proteins):
CLPSL1

Find genes that share paralogs with CLPS           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
COL_HUMAN, P04118: Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes


Selected SNPs for CLPS (see all 176)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs106339591,2
C--35762333(+) CTAGCTG/-TGTCA 3 -- ds50011Minor allele frequency- -:0.00CSA 2
rs106430681,2
C--35762334(+) GCTGT-/GT/TG 
        
CATAT
3 -- ds50010--------
rs77625151,2
C,F,A,H--35762372(+) TGAGAG/TCCCAG 3 -- ds50016Minor allele frequency- T:0.00NS EA NA 416
rs28170141,2
C,F,H--35762380(+) CAGGAC/TTCTGA 3 -- ds500111Minor allele frequency- N:0.00EA NA WA CSA 557
rs28170151,2
C,F--35762432(+) CTTACC/TCACAA 3 -- ds50013Minor allele frequency- T:0.33NA 6
rs715401221,2
C--35762438(+) CACAAGTGTGTG 
 TGTGT
/-
GTGTG
3 -- ds50011Minor allele frequency- -:0.50NA 2
rs1132041231,2
C--35762438(+) CACAAGTGTG   
   TGT
/-
GTGTG
3 -- ds50011Minor allele frequency- -:0.50CSA 2
rs94621191,2
C,A,H--35762472(+) tgtgtA/GtgtgC 3 -- ds50010--------
rs563776061,2
C--35762475(+) GTATGC/TGCGCG 3 -- ds50010--------
rs1469264631,2
--35762475(+) TATGT-/GCGC  
        
GCGCG
3 -- ds50010--------

HapMap Linkage Disequilibrium report for CLPS (35762759 - 35765102 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CLPS (see all 18):    About this table    
Variant IDTypeSubtypePubMed ID
nsv513737CNV Insertion21212237
nsv5259CNV Insertion18451855
esv990474CNV Insertion20482838
nsv821646CNV Loss15273396
nsv885805CNV Loss21882294
nsv428143CNV Gain18775914
dgv1043n67CNV Gain20364138
esv33535CNV Gain17666407
nsv819076CNV Gain19587683
dgv6834n71CNV Gain21882294

Human Gene Mutation Database (HGMD): CLPS
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CLPS
DNA2.0 Custom Variant and Variant Library Synthesis for CLPS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 120105    OMIM disorders: --

6 diseases for CLPS:    
About MalaCards
obsessive-compulsive personality disorder    johanson-blizzard syndrome    orofaciodigital syndrome    personality disorder
acute pancreatitis    steatorrhea

5 diseases from the University of Copenhagen DISEASES database for CLPS:
obsessive-compulsive personality disorder     Steatorrhea     Borderline personality disorder     Pancreatitis
Orofaciodigital syndrome

Find genes that share disorders with CLPS           About GenesLikeMe

5 Novoseek inferred disease relationships for CLPS gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic insufficiency 63.2 1 11102539 (1)
pancreatic diseases 57.5 1 1561522 (1)
pancreas exocrine 49.6 5 18726866 (1), 17395356 (1)
acute pancreatitis 1.59 1 8945483 (1)
obesity 0 4 20054203 (2), 18726866 (1)

Genetic Association Database (GAD): CLPS
Human Genome Epidemiology (HuGE) Navigator: CLPS (3 documents)

Export disorders for CLPS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CLPS gene, integrated from 10 sources (see all 131):
(articles sorted by number of sources associating them with CLPS)
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  1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PubMed id 16189801)1, 2, 4, 9 Lindner I.... Schrezenmeir J. (Mol. Nutr. Food Res. 2005)
  2. Cloning and characterization of the human colipase cDNA. (PubMed id 2337598)1, 2, 9 Lowe M.E.... Strauss A.W. (Biochemistry 1990)
  3. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. (PubMed id 18726866)1, 4, 9 Weyrich P....HAoring H.U. (amp 2009)
  4. The human colipase gene: isolation, chromosomal location, and tissue- specific expression. (PubMed id 1643046)1, 2, 9 Sims H.F. and Lowe M.E. (Biochemistry 1992)
  5. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PubMed id 2045105)1, 3, 9 Davis R.C....Lusis A.J. (Genomics 1991)
  6. Procolipase gene: no association with early-onset obesity or fat intake. (PubMed id 20054203)1, 4, 9 Wermter A.K....Hebebrand J. (Obes Facts 2009)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. (PubMed id 8479519)1, 2 van Tilbeurgh H....Cambillau C. (Nature 1993)
  9. The primary sequence of human pancreatic colipase. (PubMed id 6691986)1, 2 Sternby B....Borgstroem B. (Biochim. Biophys. Acta 1984)
  10. Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. (PubMed id 11278590)1, 9 Crandall W.V. and Lowe M.E. (J. Biol. Chem. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1208 HGNC: 2085 AceView: CLPS Ensembl:ENSG00000137392 euGenes: HUgn1208
ECgene: CLPS Kegg: 1208 H-InvDB: CLPS

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CLPS Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Colipase

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CLPS gene:
Search GeneIP for patents involving CLPS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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