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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLPP Gene

protein-coding   GIFtS: 59
GCID: GC19P006315

ClpP caseinolytic peptidase, ATP-dependent, proteolytic...

(Previous names: ClpP (caseinolytic protease, ATP-dependent, proteolytic...)
 Explore 15 diseases affiliated with
CLPP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLPP    

Aliases
for CLPP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E.
Coli)1 2
     ATP-Dependent Protease ClpAP, Proteolytic Subunit, Human2
Endopeptidase Clp2 3     ClpP Caseinolytic Peptidase ATP-Dependent, Proteolytic Subunit2
EC 3.4.21.923 8     ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog2
ClpP (Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit, E. Coli)
Homolog1
     Putative ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial2
ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog (E.
Coli)1
     

External Ids:    HGNC: 20841   Entrez Gene: 81922   Ensembl: ENSG000001256567   OMIM: 6011195   UniProtKB: Q167403   

Export aliases for CLPP gene to outside databases

Previous GC identifers: GC19P006455 GC19P006301 GC19P006313 GC19P006314 GC19P006121


Summaries
for CLPP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLPP:
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the
presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner
mitochondrial membrane. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
Function: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible
for a fairly general and central housekeeping function rather than for the degradation of specific substrates

Gene Wiki entry for CLPP


Genomic Views
for CLPP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLPP gene promoter:
         Bach1   Elk-1   AML1a   SREBP-1c   C/EBPalpha   YY1   SREBP-1b   GATA-1   PPAR-alpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLPP promoter sequence
   Search SABiosciences Chromatin IP Primers for CLPP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC chromosome: 19

CLPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006315:  view genomic region     (about GC identifiers)

Start:
 6,361,463 bp from pter      End:
 6,368,915 bp from pter
Size:
 7,453 bases      Orientation:
 plus strand

Proteins
for CLPP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740 (See protein sequence)
Recommended Name: Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor  
Size: 277 amino acids; 30180 Da
Subunit: Tetradecamer that assembles into a two heptameric rings with a central cavity
Subcellular location: Mitochondrion matrix
1 PDB 3D structure from and Proteopedia for CLPP:
1TG6 (3D)    
Secondary accessions: B2R4W5

Explore the universe of human proteins at neXtProt for CLPP: NX_Q16740

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16740

    • 4/15 DME Specific Peptides for CLPP (Q16740) (see all 15)
     PIVVEQT  YINSPGG  AIYDTMQ  RIMIHQP 

    CLPP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006003.1  
    ENSEMBL proteins: 
     ENSP00000245816  

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    Novus Biologicals CLPP Proteins
    Novus Biologicals CLPP Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CLPP
    Uscn Proteins for CLPP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IEA--


    CLPP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLPP

    Protein Domains /
    Families
    for CLPP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLPP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001907 ClpP
     IPR018215 ClpP_AS
     IPR023562 ClpP/TepA

    Graphical View of Domain Structure for InterPro Entry Q16740

    ProtoNet protein and cluster: Q16740

    1 Blocks protein family: IPB001907 Clp protease

    UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
    Similarity: Belongs to the peptidase S14 family


    Function
    for CLPP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
    Function: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible
    for a fairly general and central housekeeping function rather than for the degradation of specific substrates
    Catalytic activity: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the
    usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as
    succinyl-Leu-Tyr- -NHMec; and Leu-Tyr-Leu- -Tyr-Trp, in which cleavage of the -Tyr- -Leu- and -Tyr- -Trp bonds also
    occurs)

         Genatlas biochemistry entry for CLPP:
    ATP dependent protease involved in degradation of incorreclly folded or unfolded proteins,catalytic subunit,ClpP E coli
    homolog,highly expressed in skeletal muscle,heart,liver,pancreas,located in the mitochondrial matrix

    Enzyme Number (IUBMB): EC 3.4.21.921 2

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPP:
    hsa-miR-27a hsa-miR-128 hsa-miR-32* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: CLPP 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CLPP
    OriGene siRNA: CLPP
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI16115876
    GO:0005524ATP binding IEA--
    GO:0008233peptidase activity TAS8543061


    CLPP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLPP:
     Decreased POU5F1-GFP protein e 


    Pathways & Interactions
    for CLPP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CLPP (Q167403 ENSP000002458164) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    CLPXO760313, ENSP000003001074I2D: score=3 STRING: ENSP00000300107
    ATG5Q9H1Y03I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    CLPP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLPP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLPP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLPP

    1 HMDB Compound for CLPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CLPP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    1 Novoseek chemical compound relationship for CLPP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 37.5 2 8639751 (1), 9390554 (1)

    Search CenterWatch for drugs/clinical trials and news about CLPP 

    Transcripts
    for CLPP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLPP gene: 
    NM_006012.2  

    Unigene Cluster for CLPP:

    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
    Hs.515092  [show with all ESTs]
    Unigene Representative Sequence: BQ876313
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245816(uc002mem.1)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPP:
    hsa-miR-27a hsa-miR-128 hsa-miR-32* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: CLPP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLPP (see all 4)
    OriGene shRNA RFP: CLPP
    OriGene siRNA: CLPP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPP
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPP

    Additional cDNA sequence: 

    AK311973.1 BC002956.1 EF036491.1 Z50853.1 

    7 DOTS entries:

    DT.218708  DT.100814587  DT.92436904  DT.92436920  DT.86853291  DT.95137087  DT.100834982 

    24/294 AceView cDNA sequences (see all 294):

    BM552091 BQ018324 BE315133 CD105233 BM726814 BX092409 Z50853 BC002956 
    CB131030 CA413529 AI992154 BM990308 BE349562 CA427262 BG771353 BE675467 
    BQ434163 AI524318 AW026214 BQ006866 BE269067 BU955926 AW043864 BF109951 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLPP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
    SP1:        -     -           -                                       
    SP2:                          -                                       
    SP3:                          -                 -                     
    SP4:                                                                  
    SP5:                                      -                           


    ECgene alternative splicing isoforms for CLPP

    Expression
    for CLPP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAGGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLPP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLPP

    SOURCE GeneReport for Unigene cluster: Hs.515092

    UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
    Tissue specificity: Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low
    in brain, placenta, lung and kidney

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    In Situ
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    Orthologs
    for CLPP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CLPP gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clpp1 , 5 caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) less5
    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit less1    		 81.99(n)1
    87.13(a)1    		   17 (29.61 cM)5
    538951  NM_017393.21  NP_059089.11 
     569902645 
    lizard
    (Anolis carolinensis)    		 Reptilia CLPP6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 2(76549346-76560061)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.117232 Xenopus laevis transcribed sequence with moderate similarity to protein pirS68421 (H.sapiens) S68421 ATP-dependent clp proteinase (EC 3.4.21.-) chain P - human less 77.07(n)    BJ071154.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj37a052 Transcribed sequence with moderate similarity to protein pirS68421 (H.sapiens) S68421 ATP-dependent clp proteinase (EC 3.4.21.-) chain P - human less 79.39(n)    CK238663.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG50451 , 3 endopeptidase Clp3
    CG50451    		 70(a)3
    68.16(n)1
    70.65(a)1    		   31D103
    344021  NM_135544.21  NP_609388.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK970.23
    clpp-11    		 CLPP-like protease3
    Protein CLPP-11    		 65(a)3
    58.55(n)1
    65.08(a)1    		   II(10300153-10302691)3
    1745941  NM_063814.21  NP_496215.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NCLPP71 ATP-dependent Clp protease proteolytic subunit 2 58(n)
    60(a)    		   832378  NM_122220.4  NP_568427.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.49482 Oryza sativa (japonica cultivar-group) cDNA cloneJ013002C05, full insert sequence less 76.53(n)    AK062167.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria clpP6
    		 proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP...
    		 53(a)
    		 1 ↔ 1
    		 Chromosome(455901-456524)


    ENSEMBL Gene Tree for CLPP (if available)
    TreeFam Gene Tree for CLPP (if available) 

    Paralogs
    for CLPP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CLPP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/213 NCBI SNPs in CLPP are shown (see all 213)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1910546031,2
    		--6359490(+) ATGCCA/GAGATA 1 -- us2k10--------
    rs782423881,2
    		--6359629(+) ACCTCA/GCCTGA 1 -- us2k10--------
    rs735618641,2
    		C,F,--6359661(+) TGCCCC/TGGGAA 1 -- us2k13Minor allele frequency- T:0.06WA CSA 122
    rs1832872951,2
    		--6359662(+) GCCCCA/GGGAAA 1 -- us2k10--------
    rs126094131,2
    		C,H--6359721(+) GACTTA/CTCAGA 1 -- us2k10--------
    rs1145585791,2
    		C,F,--6359748(+) TCTAAC/TACAGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs126094251,2
    		C,H--6359801(+) CCTTTC/TTGAGG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1168988871,2
    		C,F,--6359806(+) CTGAGG/AACTTT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1452392371,2
    		--6359846(+) TATCCC/TCACTC 1 -- us2k10--------
    rs1887321041,2
    		--6360100(+) CCATTC/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLPP (6361463 - 6368915 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLPP: --

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    Disorders / Diseases
    for CLPP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLPP for disorders           About GeneDecksing

    OMIM gene information: 601119    OMIM disorders: --

    15 diseases for CLPP:    About MalaCards
    urethral intrinsic sphincter deficiency    spastic paraplegia    hereditary spastic paraplegia    dental caries
    paraplegia    urethritis    legionnaires' disease    spasticity
    pneumonia    prostate cancer    prostatitis    tuberculosis
    malaria    mycobacterium tuberculosis    sepsis

    1 disease from the University of Copenhagen DISEASES database for CLPP:
    Legionnaires' disease

    1 Novoseek disease relationship for CLPP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 33.8 4 9393683 (1), 12940983 (1), 11069659 (1), 20049702 (1)

    Human Genome Epidemiology (HuGE) Navigator: CLPP (1 document)

    Export disorders for CLPP gene to outside databases

    Publications
    for CLPP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLPP gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with CLPP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. (PubMed id 8543061)1, 2, 3, 9 Bross P.... Gregersen N. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Crystallography and mutagenesis point to an essential role for the N- terminus of human mitochondrial ClpP. (PubMed id 15522782)1, 2 Kang S.G.... Ahvazi B. (2004)
    4. Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP. (PubMed id 10525407)1, 2 de Sagarra M.R....Casta n J.G. (1999)
    5. Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). (PubMed id 18378094)1, 9 Hansen J....Bross P. (2008)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    10. Global profiling of protease cleavage sites by chemos elective labeling of protein N-termini. (PubMed id 19892738)2 Xu G....Jaffrey S.R. (2009)

    External Searches for CLPP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLPP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8192 HGNC: 2084 AceView: CLPP Ensembl:ENSG00000125656 euGenes: HUgn8192
    ECgene: CLPP H-InvDB: CLPP

    Other Databases showing CLPP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLPP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLPP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLPP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLPP gene:
    Search GeneIP for patents involving CLPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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