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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLPP Gene

protein-coding   GIFtS: 62
GCID: GC19P006315

Caseinolytic Mitochondrial Matrix Peptidase Proteolytic...

(Previous names: ClpP (caseinolytic protease, ATP-dependent, proteolytic...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit1 2     Proteolytic Subunit1
Endopeptidase Clp2 3     PRLTS32
EC 3.4.21.923 8     ATP-Dependent Protease ClpAP, Proteolytic Subunit, Human2
ATP-Dependent Protease ClpAP (E. Coli)1     ClpP Caseinolytic Peptidase ATP-Dependent, Proteolytic Subunit2
ClpP (Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit, E. Coli)
Homolog1
     ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog2
ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog
(E. Coli)1
     ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog2
ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog (E.
Coli)1
     Putative ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial2
human1     

External Ids:    HGNC: 20841   Entrez Gene: 81922   Ensembl: ENSG000001256567   OMIM: 6011195   UniProtKB: Q167403   

Export aliases for CLPP gene to outside databases

Previous GC identifers: GC19P006455 GC19P006301 GC19P006313 GC19P006314 GC19P006121


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLPP Gene:
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides
in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with
the inner mitochondrial membrane. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLPP Gene: 
CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit) is a protein-coding gene. Diseases associated with CLPP include urethral intrinsic sphincter deficiency, and urethritis. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity.

UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
Function: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be
responsible for a fairly general and central housekeeping function rather than for the degradation of specific
substrates

Gene Wiki entry for CLPP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLPP gene promoter:
         Bach1   Elk-1   AML1a   SREBP-1c   C/EBPalpha   YY1   SREBP-1b   GATA-1   PPAR-alpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPP promoter sequence
   Search SABiosciences Chromatin IP Primers for CLPP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CLPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006315:  view genomic region     (about GC identifiers)

Start:
6,361,463 bp from pter      End:
6,368,919 bp from pter
Size:
7,457 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740 (See protein sequence)
Recommended Name: Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor  
Size: 277 amino acids; 30180 Da
Subunit: Tetradecamer that assembles into a two heptameric rings with a central cavity
Subcellular location: Mitochondrion matrix
1 PDB 3D structure from and Proteopedia for CLPP:
1TG6 (3D)    
Secondary accessions: B2R4W5

Explore the universe of human proteins at neXtProt for CLPP: NX_Q16740

Explore proteomics data for CLPP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16740

  • 4/15 DME Specific Peptides for CLPP (Q16740) (see all 15)
     PIVVEQT  YINSPGG  AIYDTMQ  RIMIHQP 

    CLPP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLPP Protein Expression
    REFSEQ proteins: NP_006003.1  
    ENSEMBL proteins: 
     ENSP00000245816   ENSP00000470098   ENSP00000472227   ENSP00000469124  

    Human Recombinant Protein Products for CLPP: 
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    Novus Biologicals CLPP Lysate
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    ProSpec Recombinant Protein for CLPP
    Cloud-Clone Corp. Proteins for CLPP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IEA--

    CLPP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AATP: ATPases / AAA-type

    3 InterPro protein domains:
     IPR001907 ClpP
     IPR018215 ClpP_AS
     IPR023562 ClpP/TepA

    Graphical View of Domain Structure for InterPro Entry Q16740

    ProtoNet protein and cluster: Q16740

    1 Blocks protein domain: IPB001907 Clp protease

    UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
    Similarity: Belongs to the peptidase S14 family


    CLPP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLPP_HUMAN, Q16740
    Function: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be
    responsible for a fairly general and central housekeeping function rather than for the degradation of specific
    substrates
    Catalytic activity: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is
    the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed
    (such as succinyl-Leu-Tyr- -NHMec; and Leu-Tyr-Leu- -Tyr-Trp, in which cleavage of the -Tyr- -Leu- and -Tyr- -Trp
    bonds also occurs)

         Genatlas biochemistry entry for CLPP:
    ATP dependent protease involved in degradation of incorreclly folded or unfolded proteins,catalytic subunit,ClpP E
    coli homolog,highly expressed in skeletal muscle,heart,liver,pancreas,located in the mitochondrial matrix

         Enzyme Number (IUBMB): EC 3.4.21.921 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11923310
    GO:0005524ATP binding IEA--
    GO:0008233peptidase activity TAS8543061
         
    CLPP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLPP:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLPP 
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPP:
    hsa-miR-27a hsa-miR-128 hsa-miR-32* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidCLPP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CLPP (Q167403 ENSP000002458164) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    CLPXO760313, ENSP000003001074I2D: score=3 STRING: ENSP00000300107
    ATG5Q9H1Y03I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CLPP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLPP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLPP

    1 HMDB Compound for CLPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CLPP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    1 Novoseek inferred chemical compound relationship for CLPP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 37.5 2 8639751 (1), 9390554 (1)

    Search CenterWatch for drugs/clinical trials and news about CLPP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLPP gene: 
    NM_006012.2  

    Unigene Cluster for CLPP:

    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
    Hs.515092  [show with all ESTs]
    Unigene Representative Sequence: BQ876313
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245816(uc002mem.1) ENST00000596070 ENST00000594780 ENST00000597326
    ENST00000596149 ENST00000596605
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CLPP:
    hsa-miR-27a hsa-miR-128 hsa-miR-32* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidCLPP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK311973.1 BC002956.1 EF036491.1 Z50853.1 

    7 DOTS entries:

    DT.218708  DT.100814587  DT.92436904  DT.92436920  DT.86853291  DT.95137087  DT.100834982 

    24/294 AceView cDNA sequences (see all 294):

    BF109951 BQ006866 BU622769 BM702583 AI524318 CF128020 BQ434163 BG744414 
    H92514 CD105233 BM726814 BC002956 CF128770 BE315133 BX345961 AW043864 
    BM990308 BM974899 AW593343 BM919912 BE513389 CA413529 NM_006012 CA417619 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLPP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
    SP1:        -     -           -                                       
    SP2:                          -                                       
    SP3:                          -                 -                     
    SP4:                                                                  
    SP5:                                      -                           


    ECgene alternative splicing isoforms for CLPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLPP expression in normal human tissues (normalized intensities)      CLPP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGGGGCC
    CLPP Expression
    About this image


    CLPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Epithelium (Reproductive System)    fully expand to see all 3 entries
             cervix, uterine ; squamous epithelial cells   

    See CLPP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLPP

    SOURCE GeneReport for Unigene cluster: Hs.515092

    UniProtKB/Swiss-Prot: CLPP_HUMAN, Q16740
    Tissue specificity: Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas.
    Low in brain, placenta, lung and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLPP gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clpp1 , 5 caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) less5
    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit less1
    81.99(n)1
    87.13(a)1
      17 (29.61 cM)5
    538951  NM_017393.21  NP_059089.11 
     569902645 
    lizard
    (Anolis carolinensis)
    Reptilia CLPP6
    ClpP caseinolytic peptidase, ATP-dependent, proteo...
    75(a)
    1 ↔ 1
    2(76547511-76562658)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117232 Xenopus laevis transcribed sequence with moderate similarity to protein pirS68421 (H.sapiens) S68421 ATP-dependent clp proteinase (EC 3.4.21.-) chain P - human less 77.07(n)    BJ071154.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj37a052 Transcribed sequence with moderate similarity to protein pirS68421 (H.sapiens) S68421 ATP-dependent clp proteinase (EC 3.4.21.-) chain P - human less 79.39(n)    CK238663.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50451 , 3 endopeptidase Clp3
    CG50451
    70(a)3
    68.16(n)1
    70.65(a)1
      31D103
    344021  NM_135544.21  NP_609388.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK970.23
    clpp-11
    CLPP-like protease3
    Protein CLPP-11
    65(a)3
    58.55(n)1
    65.08(a)1
      II(10300153-10302691)3
    1745941  NM_063814.21  NP_496215.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NCLPP71 ATP-dependent Clp protease proteolytic subunit 2 58(n)
    60(a)
      832378  NM_122220.4  NP_568427.1 
    rice
    (Oryza sativa)
    Liliopsida Os.49482 Oryza sativa (japonica cultivar-group) cDNA cloneJ013002C05, full insert sequence less 76.53(n)    AK062167.1 


    ENSEMBL Gene Tree for CLPP (if available)
    TreeFam Gene Tree for CLPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 SNPs in CLPP are shown (see all 268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1910546031,2
    --6359490(+) ATGCCA/GAGATA 1 -- us2k10--------
    rs782423881,2
    --6359629(+) ACCTCA/GCCTGA 1 -- us2k10--------
    rs735618641,2
    C,F--6359661(+) TGCCCC/TGGGAA 1 -- us2k13Minor allele frequency- T:0.06WA CSA 122
    rs1832872951,2
    --6359662(+) GCCCCA/GGGAAA 1 -- us2k10--------
    rs126094131,2
    C,H--6359721(+) GACTTA/CTCAGA 1 -- us2k10--------
    rs1145585791,2
    C,F--6359748(+) TCTAAC/TACAGC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs126094251,2
    C,H--6359801(+) CCTTTC/TTGAGG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1168988871,2
    C,F--6359806(+) CTGAGG/AACTTT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1452392371,2
    C--6359846(+) TATCCC/TCACTC 1 -- us2k10--------
    rs1887321041,2
    --6360100(+) CCATTC/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLPP (6361463 - 6368919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLPP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910916CNV Loss21882294
    nsv910911CNV Loss21882294
    dgv3698n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): CLPP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLPP
    DNA2.0 Custom Variant and Variant Library Synthesis for CLPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601119    OMIM disorders: --

    11 diseases for CLPP:    About MalaCards
    urethral intrinsic sphincter deficiency    urethritis    legionnaires' disease    dental caries
    hereditary spastic paraplegia    paraplegia    spasticity    pneumonia
    tuberculosis    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CLPP:
    Legionnaires' disease

    CLPP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for CLPP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 33.8 4 9393683 (1), 12940983 (1), 11069659 (1), 20049702 (1)

    Genetic Association Database (GAD): CLPP
    Human Genome Epidemiology (HuGE) Navigator: CLPP (1 document)

    Export disorders for CLPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLPP gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CLPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. (PubMed id 8543061)1, 2, 3, 9 Bross P.... Gregersen N. (1995)
    2. Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain. (PubMed id 23360988)1, 3 Fischer F....Osiewacz H.D. (2013)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Crystallography and mutagenesis point to an essential role for the N- terminus of human mitochondrial ClpP. (PubMed id 15522782)1, 2 Kang S.G.... Ahvazi B. (2004)
    6. Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP. (PubMed id 10525407)1, 2 de Sagarra M.R....Casta n J.G. (1999)
    7. Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). (PubMed id 18378094)1, 9 Hansen J....Bross P. (2008)
    8. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. (PubMed id 23541340)1 Jenkinson E.M....Newman W.G. (2013)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8192 HGNC: 2084 AceView: CLPP Ensembl:ENSG00000125656 euGenes: HUgn8192
    ECgene: CLPP H-InvDB: CLPP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLPP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLPP gene:
    Search GeneIP for patents involving CLPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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