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CLPB Gene

protein-coding   GIFtS: 56
GCID: GC11M072008

ClpB Caseinolytic Peptidase B Homolog (E. Coli)

  See CLPB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ClpB Caseinolytic Peptidase B Homolog (E. Coli)1 2
Suppressor Of Potassium Transport Defect 31 2 3
HSP782 3
SKD32 3
Caseinolytic Peptidase B Protein Homolog2

External Ids:    HGNC: 306641   Entrez Gene: 815702   Ensembl: ENSG000001621297   UniProtKB: Q9H0783   

Export aliases for CLPB gene to outside databases

Previous GC identifers: GC11M071682 GC11M071683 GC11M068296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CLPB Gene:
CLPB (ClpB caseinolytic peptidase B homolog (E. coli)) is a protein-coding gene. Diseases associated with CLPB include tularemia. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078
Function: May function as a regulatory ATPase and be related to secretion/protein trafficking process

Gene Wiki entry for CLPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLPB gene promoter:
         Max1   HFH-3   Evi-1   Arnt   FOXI1   RORalpha1   Nkx6-1   USF-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLPB promoter sequence
   Search Chromatin IP Primers for CLPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

CLPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLPB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M072008:  view genomic region     (about GC identifiers)

Start:
72,003,469 bp from pter      End:
72,145,692 bp from pter
Size:
142,224 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078 (See protein sequence)
Recommended Name: Caseinolytic peptidase B protein homolog  
Size: 707 amino acids; 78729 Da
Secondary accessions: B4DXJ7 B4DXP7 E7EWN6 F8W7P6 Q8ND11 Q9H8Y0
Alternative splicing: 4 isoforms:  Q9H078-1   Q9H078-2   Q9H078-3   Q9H078-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLPB: NX_Q9H078

Explore proteomics data for CLPB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245321.1  NP_001245322.1  NP_001245323.1  NP_110440.1  

    ENSEMBL proteins: 
     ENSP00000294053   ENSP00000441518   ENSP00000443822   ENSP00000340385   ENSP00000439746  
     ENSP00000445180   ENSP00000440423   ENSP00000438372   ENSP00000442651   ENSP00000445327  
     ENSP00000473985   ENSP00000441804   ENSP00000407296  

    CLPB Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLPB
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    Novus Biologicals CLPB Protein
    Novus Biologicals CLPB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLPB

     
    Search eBioscience for Proteins for CLPB 

     
    antibodies-online proteins for CLPB (3 products) 

     
    antibodies-online peptides for CLPB

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    antibodies-online antibodies for CLPB (19 products) 

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    antibodies-online kits for CLPB (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR001270 ClpA/B
     IPR002110 Ankyrin_rpt
     IPR019489 Clp_ATPase_C
     IPR013093 ATPase_AAA-2
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H078

    ProtoNet protein and cluster: Q9H078

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078
    Similarity: Belongs to the ClpA/ClpB family
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with CLPB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLPB_HUMAN, Q9H078
    Function: May function as a regulatory ATPase and be related to secretion/protein trafficking process

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008134transcription factor binding ----
         
    Find genes that share ontologies with CLPB           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CLPB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLPB:
    hsa-mir-324-5p (MIRT043166), hsa-let-7a-5p (MIRT052510)

    Block miRNA regulation of human, mouse, rat CLPB using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CLPB:
    hsa-miR-22 hsa-miR-4303 hsa-miR-185* hsa-miR-339-5p hsa-miR-3179 hsa-miR-3160-3p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLPB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLPB
    Predesigned siRNA for gene silencing in human, mouse, rat CLPB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CLPB (NM_030813)
    Sino Biological Human cDNA Clone for CLPB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPB

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    chloroplast2
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with CLPB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLPB
    Interactions:

        Search GeneGlobe Interaction Network for CLPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLPB (Q9H0782, 3 ENSP000002940534) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62143 I2D: score=3 
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    TTF2Q9UNY43, ENSP000003584784I2D: score=2 STRING: ENSP00000358478
    UCHL3P153743, ENSP000003668194I2D: score=2 STRING: ENSP00000366819
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0034605cellular response to heat IDA2745427

    Find genes that share ontologies with CLPB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLPB

    1 Novoseek inferred chemical compound relationship for CLPB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 11.2 1 16307477 (1)



    Find genes that share compounds with CLPB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLPB gene (4 alternative transcripts): 
    NM_001258392.1  NM_001258393.1  NM_001258394.1  NM_030813.4  

    Unigene Cluster for CLPB:

    ClpB caseinolytic peptidase B homolog (E. coli)
    Hs.523877  [show with all ESTs]
    Unigene Representative Sequence: NM_001258394
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294053(uc001osi.3 uc001osj.3 uc010rqx.2 uc010rqy.2 uc001osk.3 uc010rqz.2)
    ENST00000538039 ENST00000535990 ENST00000340729 ENST00000543042 ENST00000538021
    ENST00000535477 ENST00000544382 ENST00000544683 ENST00000539148 ENST00000445069
    ENST00000536297 ENST00000542555 ENST00000437826
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLPB using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CLPB:
    hsa-miR-22 hsa-miR-4303 hsa-miR-185* hsa-miR-339-5p hsa-miR-3179 hsa-miR-3160-3p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLPB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLPB
    Predesigned siRNA for gene silencing in human, mouse, rat CLPB
    Clone
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    OriGene clones in human, mouse for CLPB (see all 7)
    OriGene ORF clones in mouse, rat for CLPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLPB (NM_030813)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPB
    Primer
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    OriGene qPCR primer pairs and template standards for CLPB
    OriGene qSTAR qPCR primer pairs in human, mouse for CLPB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLPB
      QuantiTect SYBR Green Assays in human, mouse, rat CLPB
      QuantiFast Probe-based Assays in human, mouse, rat CLPB

    Additional mRNA sequence: 

    AK023214.1 AK302006.1 AK302069.1 AK302158.1 AL136909.1 AL834484.1 BC006257.2 BC006404.2 

    12 DOTS entries:

    DT.413209  DT.100703862  DT.100783130  DT.97801646  DT.95340495  DT.100687821  DT.100783129  DT.120729932 
    DT.120729943  DT.430302  DT.100766908  DT.97836534 

    Selected AceView cDNA sequences (see all 194):

    CR615664 NM_030813 BC006257 BG831089 BE541089 BU848809 BC006404 CA422624 
    BM048086 BF968062 AA535609 BQ948032 BX348749 BM673596 BE886629 AK023214 
    BF062078 R16228 AL136909 AA127442 BQ005342 BG256660 AU131870 AL043936 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CLPB    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                                                                                  -                                                         
    SP2:                                                  -                                               -                                                         
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                      -           -                                                                                                         


    ECgene alternative splicing isoforms for CLPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCTCCCAT
    CLPB Expression
    About this image


    CLPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CLPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523877
        Custom PCR Arrays for CLPB
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    QuantiFast Probe-based Assays in human, mouse, rat CLPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLPB gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clpb1 , 5 ClpB caseinolytic peptidase B homolog (E. coli)5
    ClpB caseinolytic peptidase B1
    86.02(n)1
    88.33(a)1
      7 (54.63 cM)5
    204801  NM_009191.31  NP_033217.11 
     1016636335 
    chicken
    (Gallus gallus)
    Aves CLPB6
    ClpB caseinolytic peptidase B homolog (E. coli)
    87(a)
    1 ↔ 1
    JH375664.1(21-5695)
    lizard
    (Anolis carolinensis)
    Reptilia CLPB6
    ClpB caseinolytic peptidase B homolog (E. coli)
    77(a)
    1 ↔ 1
    GL343897.1(13080-125101)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59642 Xenopus laevis transcribed sequence with moderate similarity more 79.83(n)    BJ068623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003315871 caseinolytic peptidase B protein homolog 73.55(n)
    77.15(a)
      100331587  XM_002664753.2  XP_002664799.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSP78(YDR258C)4 Oligomeric mitochondrial matrix chaperone that cooperates more   --   4(974243-971808) 851845  NP_010544.1 
    soybean
    (Glycine max)
    eudicotyledons L35272.12   -- 74.04(n)    L35272.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48592 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.3(n)    AK066153.1 


    ENSEMBL Gene Tree for CLPB (if available)
    TreeFam Gene Tree for CLPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLPB (see all 2458)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854657621,2
    --72003186(+) ACCCTA/GGATTC 4 -- ds50010--------
    rs1905223321,2
    --72003296(+) ACTACA/GCGAGG 4 -- ds50010--------
    rs1422771081,2
    --72003411(+) GTGGGC/TTTGAA 4 -- ds50010--------
    rs1827460711,2
    --72003644(+) GGAGGC/TCCCCA 4 -- ut310--------
    rs5263441,2
    C,F,O,A,H--72003767(-) GTTTCG/TTCAGC 4 -- ut31 ese327Minor allele frequency- T:0.45MN EA NA NS WA CSA 3281
    rs118245671,2
    C,H--72003793(+) CCCAGG/TACGTG 4 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs1460712041,2
    C--72003919(+) ACTATA/CTGCAC 4 -- ut310--------
    rs752016711,2
    C,F--72003994(+) CTAGCA/CGAGGG 4 -- ut311Minor allele frequency- C:0.08WA 118
    rs1888442351,2
    --72004024(+) CTGTCG/TTCTTC 4 -- ut310--------
    rs751281061,2
    C,F--72004156(+) TGAAGG/TGGGTG 4 -- ut311Minor allele frequency- T:0.08WA 118

    HapMap Linkage Disequilibrium report for CLPB (72003469 - 72145692 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CLPB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2339545CNV Deletion18987734
    esv2744769CNV Deletion23290073
    esv1000322CNV Deletion20482838
    esv2662493CNV Deletion23128226
    esv267422CNV Insertion20981092
    nsv385CNV Insertion18451855
    esv274124CNV Insertion20981092
    nsv825990CNV Loss20364138
    esv8221CNV Gain19470904
    nsv832206CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CLPB:    
    About MalaCards
    tularemia

    1 disease from the University of Copenhagen DISEASES database for CLPB:
    Tularemia

    Find genes that share disorders with CLPB           About GenesLikeMe

    1 Novoseek inferred disease relationship for CLPB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 41 1 20018266 (1)

    Genetic Association Database (GAD): CLPB
    Human Genome Epidemiology (HuGE) Navigator: CLPB (1 document)

    Export disorders for CLPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLPB gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CLPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family. (PubMed id 7835694)1, 3 PAcrier F....Vandenberg C.A. (Gene 1995)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
    10. DnaK-mediated association of ClpB to protein aggregates. A bichaperone network at the aggregate surface. (PubMed id 19698713)1 AcebrA^n S.P....Muga A. (FEBS Lett. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81570 HGNC: 30664 AceView: SKD3 Ensembl:ENSG00000162129 euGenes: HUgn81570
    ECgene: CLPB H-InvDB: CLPB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLPB gene:
    Search GeneIP for patents involving CLPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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