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Aliases for CLPB Gene

Aliases for CLPB Gene

  • ClpB Homolog, Mitochondrial AAA ATPase Chaperonin 2 3
  • Suppressor Of Potassium Transport Defect 3 2 3 4
  • Ankyrin-Repeat Containing Bacterial Clp Fusion 2 3
  • HSP78 3 4
  • SKD3 3 4
  • ClpB Caseinolytic Peptidase B Homolog (E. Coli) 2
  • Caseinolytic Peptidase B Protein Homolog 3
  • ClpB Caseinolytic Peptidase B Homolog 3
  • ANKCLB 3
  • MGCA7 3

External Ids for CLPB Gene

Previous GeneCards Identifiers for CLPB Gene

  • GC11M071682
  • GC11M071683
  • GC11M072008
  • GC11M068296

Summaries for CLPB Gene

GeneCards Summary for CLPB Gene

CLPB (ClpB Homolog, Mitochondrial AAA ATPase Chaperonin) is a Protein Coding gene. Diseases associated with CLPB include tularemia. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for CLPB Gene

  • May function as a regulatory ATPase and be related to secretion/protein trafficking process

Gene Wiki entry for CLPB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLPB Gene

Genomics for CLPB Gene

Regulatory Elements for CLPB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLPB Gene

72,292,425 bp from pter
72,434,680 bp from pter
142,256 bases
Minus strand

Genomic View for CLPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPB Gene

Proteins for CLPB Gene

  • Protein details for CLPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Caseinolytic peptidase B protein homolog
    Protein Accession:
    Secondary Accessions:
    • B4DXJ7
    • B4DXP7
    • B4DXW4
    • E7EWN6
    • F8W7P6
    • Q8ND11
    • Q9H8Y0

    Protein attributes for CLPB Gene

    707 amino acids
    Molecular mass:
    78729 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLPB Gene


neXtProt entry for CLPB Gene

Proteomics data for CLPB Gene at MOPED

Post-translational modifications for CLPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLPB Gene

Domains for CLPB Gene

Gene Families for CLPB Gene

  • ANKRD :Ankyrin repeat domain containing

Suggested Antigen Peptide Sequences for CLPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H078
  • Belongs to the ClpA/ClpB family.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with CLPB: view

Function for CLPB Gene

Molecular function for CLPB Gene

UniProtKB/Swiss-Prot Function:
May function as a regulatory ATPase and be related to secretion/protein trafficking process

Gene Ontology (GO) - Molecular Function for CLPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with CLPB: view

Animal Model Products

miRNA for CLPB Gene

miRTarBase miRNAs that target CLPB

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLPB Gene

Localization for CLPB Gene

Subcellular locations from

Jensen Localization Image for CLPB Gene COMPARTMENTS Subcellular localization image for CLPB gene
Compartment Confidence
mitochondrion 3
chloroplast 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CLPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CLPB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CLPB Gene

Pathways for CLPB Gene

SuperPathways for CLPB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0034605 cellular response to heat IDA 2745427
genes like me logo Genes that share ontologies with CLPB: view

No data available for Pathways by source for CLPB Gene

Compounds for CLPB Gene

(1) Novoseek inferred chemical compound relationships for CLPB Gene

Compound -log(P) Hits PubMed IDs
atp 11.2 1
genes like me logo Genes that share compounds with CLPB: view

Transcripts for CLPB Gene

Unigene Clusters for CLPB Gene

ClpB caseinolytic peptidase B homolog (E. coli):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLPB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLPB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP2: - -
SP4: -
SP5: - -

Relevant External Links for CLPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLPB Gene

mRNA expression in normal human tissues for CLPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPB Gene

This gene is overexpressed in Testis (21.8).

Protein differential expression in normal tissues for CLPB Gene

This gene is overexpressed in Brain (7.7), Peripheral blood mononuclear cells (6.7), and Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLPB Gene

SOURCE GeneReport for Unigene cluster for CLPB Gene Hs.523877

genes like me logo Genes that share expressions with CLPB: view

Expression partners for CLPB Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CLPB Gene

Orthologs for CLPB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLPB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLPB 35
  • 90 (n)
  • 92.61 (a)
  • 93 (a)
(Canis familiaris)
Mammalia CLPB 35
  • 91.61 (n)
  • 92.36 (a)
  • 89 (a)
(Mus musculus)
Mammalia Clpb 35
  • 86.02 (n)
  • 88.33 (a)
Clpb 16
Clpb 36
  • 88 (a)
(Pan troglodytes)
Mammalia CLPB 35
  • 99.58 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Clpb 35
  • 85.87 (n)
  • 88.77 (a)
(Monodelphis domestica)
Mammalia CLPB 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CLPB 36
  • 71 (a)
(Gallus gallus)
Aves CLPB 36
  • 87 (a)
(Anolis carolinensis)
Reptilia CLPB 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clpb 35
  • 74.42 (n)
  • 80.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5964 35
(Danio rerio)
Actinopterygii LOC100331587 35
  • 73.55 (n)
  • 77.15 (a)
  • 77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP104 36
  • 16 (a)
HSP78 36
  • 18 (a)
HSP78 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7808 35
(Hordeum vulgare)
Liliopsida Hv.3721 35
(Oryza sativa)
Liliopsida Os.4859 35
Os04g0397100 35
  • 53.6 (n)
  • 43.53 (a)
(Zea mays)
Liliopsida Zm.438 35
Species with no ortholog for CLPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLPB Gene

Gene Tree for CLPB (if available)
Gene Tree for CLPB (if available)

Paralogs for CLPB Gene

No data available for Paralogs for CLPB Gene

Variants for CLPB Gene

Sequence variations from dbSNP and Humsavar for CLPB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10548 -- 72,294,058(+) ACATT(A/G)TAGCC reference, synonymous-codon
rs472837 -- 72,296,106(-) CATAC(A/G)TAACA intron-variant
rs474629 -- 72,295,933(-) TTCTG(C/G)ATGCC intron-variant
rs504217 -- 72,295,042(-) CATCC(A/G)GCAGG intron-variant
rs526344 -- 72,292,723(-) GTTTC(G/T)TCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLPB Gene

Variant ID Type Subtype PubMed ID
nsv385 CNV Insertion 18451855
nsv832206 CNV Gain 17160897
esv2744769 CNV Deletion 23290073
esv2339545 CNV Deletion 18987734
esv2662493 CNV Deletion 23128226
nsv825990 CNV Loss 20364138
esv1000322 CNV Deletion 20482838
esv8221 CNV Gain 19470904
esv267422 CNV Insertion 20981092
esv274124 CNV Insertion 20981092

Relevant External Links for CLPB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLPB Gene

Disorders for CLPB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CLPB Gene in MalaCards »

(1) Diseases for CLPB Gene including...

(1) University of Copenhagen DISEASES for CLPB Gene

(1) Novoseek inferred disease relationships for CLPB Gene

Disease -log(P) Hits PubMed IDs
shock 41 1

Relevant External Links for CLPB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLPB: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CLPB Gene

Publications for CLPB Gene

  1. Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family. (PMID: 7835694) PAcrier F. … Vandenberg C.A. (Gene 1995) 2 3
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria. (PMID: 25650066) Capo-Chichi J.M. … Michaud J.L. (J. Med. Genet. 2015) 2 3

Products for CLPB Gene

Sources for CLPB Gene

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