CLPB Gene
protein-coding GIFtS: 51
GCID: GC11M072008
|
|
ClpB caseinolytic peptidase B homolog (E. coli)
| |
Aliases
for CLPB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ClpB Caseinolytic Peptidase B Homolog (E. Coli)1 2 | | HSP781 2 3 | | SKD31 2 3 | | Suppressor Of Potassium Transport Defect 32 3 | | FLJ131521 | | Caseinolytic Peptidase B Protein Homolog2 |
Export aliases for CLPB gene to outside databasesPrevious GC identifers: GC11M071682 GC11M071683 GC11M068296 |
Summaries
for CLPB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078Function: May function as a regulatory ATPase and be related to secretion/protein trafficking process
Gene Wiki entry for CLPB
|
Genomic Views
for CLPB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLPB gene promoter:
Max1 HFH-3 Evi-1 Arnt FOXI1 RORalpha1 Nkx6-1 USF-1 STAT3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLPB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4CLPB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M072008: view genomic region
(about GC identifiers)
Start:
|
72,003,469 bp from pter |
End:
|
72,145,692 bp from pter |
Size:
|
142,224 bases |
Orientation:
|
minus strand |
|
Proteins
for CLPB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078 (See
protein sequence)Recommended Name: Caseinolytic peptidase B protein homolog Size: 707 amino acids; 78729 Da
Secondary accessions: B4DXJ7 B4DXP7 E7EWN6 F8W7P6 Q8ND11 Q9H8Y0Alternative splicing: 4 isoforms: Q9H078-1 Q9H078-2 Q9H078-3 Q9H078-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CLPB: NX_Q9H078
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H078
CLPB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001245321.1 NP_001245322.1 NP_001245323.1 NP_110440.1
ENSEMBL proteins: ENSP00000294053 ENSP00000441518 ENSP00000443822 ENSP00000340385 ENSP00000439746 ENSP00000445180 ENSP00000440423 ENSP00000438372 ENSP00000442651 ENSP00000445327 ENSP00000441804 ENSP00000407296
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005739 | mitochondrion |
IEA | -- |
CLPB for ontologies About GeneDecksing
CLPB Antibody Products:
Assay Products for CLPB: |
Protein
Domains /
Families
for CLPB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLPB for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9H078ProtoNet protein and cluster: Q9H078 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078Similarity: Belongs to the clpA/clpB familySimilarity: Contains 4 ANK repeats |
Function
for CLPB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLPB_HUMAN, Q9H078Function: May function as a regulatory ATPase and be related to secretion/protein trafficking process
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLPB (NM_030813) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLPB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPB |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
CLPB for ontologies About GeneDecksing
|
Pathways & Interactions
for CLPB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLPB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/39 Interacting proteins for CLPB (Q9H0782, 3 ENSP000002940534) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0034605 | cellular response to heat |
IDA | 2745427 |
CLPB for ontologies About GeneDecksing
|
Drugs & Compounds
for CLPB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLPB for compounds About GeneDecksing
 Browse Tocris compounds for CLPB
1 Novoseek chemical compound relationship for CLPB gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
11.2 |
1 |
16307477 (1) |
Search CenterWatch for drugs/clinical trials and news about CLPB
|
Transcripts
for CLPB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLPB gene (4 alternative transcripts): NM_001258392.1 NM_001258393.1 NM_001258394.1 NM_030813.4 Unigene Cluster for CLPB: ClpB caseinolytic peptidase B homolog (E. coli) Hs.523877 [show with all ESTs]Unigene Representative Sequence: NM_00125839415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294053(uc001osi.3 uc001osj.3 uc010rqx.2 uc010rqy.2 uc001osk.3 uc010rqz.2)
ENST00000538039 ENST00000535990 ENST00000340729 ENST00000543042 ENST00000538021
ENST00000535477 ENST00000544382 ENST00000544683 ENST00000539148 ENST00000445069
ENST00000536297 ENST00000542555 ENST00000540471 ENST00000437826
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLPB (NM_030813) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLPB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPB |
Additional cDNA sequence: AK023214.1 AK302006.1 AK302069.1 AK302158.1 AL136909.1 AL834484.1 BC006257.2 BC006404.2 12 DOTS entries: DT.413209 DT.100703862 DT.100783130 DT.97801646 DT.95340495 DT.100687821 DT.100783129 DT.120729932 DT.120729943 DT.430302 DT.100766908 DT.97836534 24/194 AceView cDNA sequences (see all 194): AA535609 BG831089 BQ948032 BF968062 R16228 BU848809 AA127442 BC006404 AL136909 BM048086 CA422624 BQ642006 AU131870 BP371139 BE541089 BC006257 BG256660 Z40910 BU181690 BE886629 CR615664 BQ445996 AK023214 BF062078
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CLPB About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLPB
|
Expression
for CLPB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCTCCCAT
About this image
See CLPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLPB
SOURCE GeneReport for Unigene cluster: Hs.523877
SABiosciences Custom PCR Arrays for CLPB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLPB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLPB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPB |
Orthologs
for CLPB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CLPB gene from 8/33 species (see all 33) About this table
ENSEMBL Gene Tree for CLPB (if available)
TreeFam Gene Tree for CLPB (if available) |
Paralogs
for CLPB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CLPB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLPB (72003469 - 72145692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CLPB
1 CNV: 35014
1 Indel: 60049 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLPB |
|
Disorders
/ Diseases
for CLPB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLPB for disorders About GeneDecksing
7  diseases for CLPB: About MalaCardspsychogenic depressive psychosis tularemia gastroenteritis pneumonia
tuberculosis malaria mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for CLPB:Tularemia 1 Novoseek disease relationship for CLPB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
41 |
1 |
20018266 (1) |
Human Genome Epidemiology (HuGE) Navigator: CLPB (1 document)
Export disorders for CLPB gene to outside databases
|
Publications
for CLPB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLPB gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with CLPB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family. (PubMed id 7835694)1, 3 Perier F....Vandenberg C.A. (1995)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- DnaK-mediated association of ClpB to protein aggregat es. A bichaperone network at the aggregate surface. (PubMed id 19698713)1 AcebrA^n S.P....Muga A. (2009)
|
External Searches for CLPB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLPB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLPB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLPB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLPB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLPB gene:
Search GeneIP for patents involving CLPB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLPB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLPB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLPB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLPB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLPB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLPB |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CLPB |
| |  |  |  |  | | | | |
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 |
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 | | | CLPB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLPB |
|  |  |  | | | | ThermoFisher Antibodies for CLPB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLPB |
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