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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLP1 Gene

protein-coding   GIFtS: 57
GCID: GC11P057425

cleavage and polyadenylation factor I subunit 1

(Previous names: CLP1, cleavage and polyadenylation factor I subunit, homolog...)
 Explore 4 diseases affiliated with
CLP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLP1    

Aliases
for CLP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cleavage And Polyadenylation Factor I Subunit 11 2     CLP1, Cleavage And Polyadenylation Factor I Subunit, Homolog (S. Cerevisiae)1
HEAB1 2 3     ATP/GTP-Binding Protein2
HClp11     CLP1, Cleavage And Polyadenylation Factor I Subunit, Homolog2
Polynucleotide Kinase Clp12 3     Homolog Of Yeast CFIA Subunit Clp1p2
Pre-MRNA Cleavage Complex II Protein Clp12 3     Polyribonucleotide 5'-Hydroxyl-Kinase Clp12
EC 2.7.1.783 8     Polyadenylation Factor Clp13

External Ids:    HGNC: 169991   Entrez Gene: 109782   Ensembl: ENSG000001724097   OMIM: 6087575   UniProtKB: Q929893   

Export aliases for CLP1 gene to outside databases

Previous GC identifers: GC11P057182 GC11P053774


Summaries
for CLP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CLP1_HUMAN, Q92989
Function: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA),
single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated
more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA
component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing
endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation
event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA.
Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also
phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary
prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and
microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate
group, so this protein may be dispensible for normal RNA-mediated gene silencing




Genomic Views
for CLP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLP1 gene promoter:
         C/EBPbeta   GCNF   Arnt   AREB6   CREB   IRF-2   NRF-2   deltaCREB   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

CLP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057425:  view genomic region     (about GC identifiers)

Start:
 57,416,465 bp from pter      End:
 57,429,340 bp from pter
Size:
 12,876 bases      Orientation:
 plus strand

Proteins
for CLP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLP1_HUMAN, Q92989 (See protein sequence)
Recommended Name: Polyribonucleotide 5'-hydroxyl-kinase Clp1  
Size: 425 amino acids; 47646 Da
Cofactor: Magnesium, manganese or nickel
Subunit: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54.
Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage
complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK
Subcellular location: Nucleus
Secondary accessions: B2R7J6 B4DTI8
Alternative splicing: 2 isoforms:  Q92989-1   Q92989-2   

Explore the universe of human proteins at neXtProt for CLP1: NX_Q92989

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92989

    • 4/14 DME Specific Peptides for CLP1 (Q92989) (see all 14)
     RDLPHFVRT  NRRASVSGC  CRLLLNYAVR  LSPAPRPLPK 

    CLP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136069.1  NP_006822.1  

    ENSEMBL proteins: 
     ENSP00000435287   ENSP00000433406   ENSP00000434995   ENSP00000431744   ENSP00000436066  
     ENSP00000304704  
    Reactome Protein details: Q92989
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CLP1
    OriGene Protein Over-expression Lysate (see all 2): CLP1
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    Novus Biologicals CLP1 Proteins
    Novus Biologicals CLP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000214tRNA-intron endonuclease complex IDA17495927
    GO:0005654nucleoplasm TAS--


    CLP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLP1

    Protein Domains /
    Families
    for CLP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010655 Pre-mRNA_cleavage_cplxII_Clp1

    Graphical View of Domain Structure for InterPro Entry Q92989

    ProtoNet protein and cluster: Q92989

    1 Blocks protein family: IPB010655 Pre-mRNA cleavage complex II Clp1

    UniProtKB/Swiss-Prot: CLP1_HUMAN, Q92989
    Similarity: Belongs to the Clp1 family. Clp1 subfamily


    Function
    for CLP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLP1_HUMAN, Q92989
    Function: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA),
    single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated
    more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA
    component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing
    endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation
    event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA.
    Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also
    phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary
    prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and
    microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate
    group, so this protein may be dispensible for normal RNA-mediated gene silencing
    Catalytic activity: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA
    Catalytic activity: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA

    Enzyme Number (IUBMB): EC 2.7.1.781 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CLP1 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-miR-3927 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: CLP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLP1 (see all 7)
    OriGene shRNA RFP: CLP1
    OriGene siRNA: CLP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLP1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLP1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CLP1 (NM_006831)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLP1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding TAS8896421
    GO:0046404ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IEA--
    GO:0051733polydeoxyribonucleotide kinase activity IDA17495927
    GO:0051736ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity IDA17495927


    CLP1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CLP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    		Post-Elongation Processing of the Transcript1.00
    		mRNA 3'-end processing0.79
    		Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    3Post-Elongation Processing of Intronless pre-mRNA
    		Processing of Capped Intronless Pre-mRNA1.00
    		Processing of Intronless Pre-mRNAs0.61
    		Post-Elongation Processing of Intronless pre-mRNA1.00
    4Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    5mRNA surveillance pathway
    		mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CLP1 
        mRNA processing

    5/15        Reactome Pathways for CLP1 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for CLP1):
        mRNA surveillance pathway


    CLP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/611 Interacting proteins for CLP1 (Q929892, 3 ENSP000003047044) via UniProtKB, MINT, STRING, and/or I2D (see all 611)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF2Q9P2I02, 3, ENSP000002988754MINT-7945693 I2D: score=1 STRING: ENSP00000298875
    CPSF3Q9UKF62, 3, ENSP000002381124MINT-7945693 I2D: score=1 STRING: ENSP00000238112
    CPSF7Q8N6842, 3, ENSP000003454124MINT-7945693 I2D: score=1 STRING: ENSP00000345412
    NUDT21O438093, ENSP000003002914I2D: score=3 STRING: ENSP00000300291
    TSEN34Q9BSV63, ENSP000003055244I2D: score=1 STRING: ENSP00000305524
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation IDA17495927
    GO:0006397mRNA processing TAS--


    CLP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLP1
    Search CenterWatch for drugs/clinical trials and news about CLP1 

    Transcripts
    for CLP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLP1 gene (2 alternative transcripts): 
    NM_001142597.1  NM_006831.2  

    Unigene Cluster for CLP1:

    Cleavage and polyadenylation factor I subunit 1
    Hs.523687  [show with all ESTs]
    Unigene Representative Sequence: U73524
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529773 ENST00000529430 ENST00000533682(uc001nkw.3 uc010rjw.2 uc009yml.3)
    ENST00000533905 ENST00000525602 ENST00000302731

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CLP1 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-miR-3927 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: CLP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLP1 (see all 7)
    OriGene shRNA RFP: CLP1
    OriGene siRNA: CLP1
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLP1

    Additional cDNA sequence: 

    AK300232.1 AK313007.1 BC000446.1 U73524.1 

    5 DOTS entries:

    DT.416520  DT.97822953  DT.100670080  DT.100748469  DT.95358805 

    24/134 AceView cDNA sequences (see all 134):

    AI738527 CA418983 AI248822 AI243334 BQ574764 BC000446 AI564856 AW004029 
    BX116274 BF433054 AW002003 AW068230 CF242788 AI148535 AI962399 AI128497 
    BM996840 AA613364 AW072178 BF110257 AI369143 CD365263 AA878365 AI016679 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b
    SP1:                                                      
    SP2:                                -     -               
    SP3:                    -                                 


    ECgene alternative splicing isoforms for CLP1

    Expression
    for CLP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACTGTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLP1

    SOURCE GeneReport for Unigene cluster: Hs.523687
        SABiosciences Custom PCR Arrays for CLP1
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLP1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLP1

    Orthologs
    for CLP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLP1 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clp11 , 5 CLP1, cleavage and polyadenylation factor I subunit, more5
    CLP1, cleavage and polyadenylation factor I subunit1    		 90.04(n)1
    98.59(a)1    		   2 (49.45 cM)5
    989851  NM_133840.21  NP_598601.11 
     847231225 
    chicken
    (Gallus gallus)    		 Aves CLP11 CLP1, cleavage and polyadenylation factor I subunit, more 79.69(n)
    93.18(a)    		   423131  NM_001012292.1  NP_001012292.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLP16
    		 --
    		 94(a)
    		 1 ↔ 1
    		 1(91588391-91592959)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA790819.12   -- 74.71(n)    CA790819.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5656211 polyribonucleotide 5'-hydroxyl-kinase Clp1-like 71.03(n)
    81.11(a)    		   565621  XM_688892.4  XP_693984.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cbc1 crowded by cid 58.76(n)
    56.97(a)    		   36494  NM_137032.3  NP_610876.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea clpf-11 Protein CLPF-1 51.34(n)
    48.9(a)    		   175442  NM_001047393.1  NP_001040858.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CLP1(YOR250C)4
    CLP11    		 Subunit of cleavage factor I (CFI), involved in both more4
    Clp1p1    		 40.59(n)1
    26.58(a)1    		   15(802307-800970)4
    8544241, 4  NP_014893.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CLPS31 CLP-like protein 3 48.77(n)
    43.1(a)    		   819626  NM_111340.2  NP_187119.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g02175001 hypothetical protein 48.46(n)
    40.05(a)    		   4328733  NM_001052834.1  NP_001046299.1 


    ENSEMBL Gene Tree for CLP1 (if available)
    TreeFam Gene Tree for CLP1 (if available) 

    Paralogs
    for CLP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CLP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 NCBI SNPs in CLP1 are shown (see all 110)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1905271331,2
    		--57423331(+) CTCGCA/GCTGTC 2 -- us2k10--------
    rs1817884541,2
    		--57423357(+) CAGTGC/GCAGGA 2 -- us2k10--------
    rs17838221,2
    		C,F--57423367(-) TGAGCT/CGAGAT 2 -- us2k13Minor allele frequency- C:0.33NA 6
    rs1851216311,2
    		--57423576(+) TACAGA/GCGTGA 2 -- us2k10--------
    rs1886986371,2
    		--57423745(+) CAGGCA/GCCCGC 2 -- us2k10--------
    rs1812788721,2
    		--57423811(+) GTCAGC/GCTGGT 2 -- us2k10--------
    rs1854789741,2
    		--57423824(+) CGAACC/TCCTGA 2 -- us2k10--------
    rs116076021,2
    		H--57423887(+) gagccA/Cccgcg 2 -- us2k10--------
    rs1463067291,2
    		--57423902(+) GCCTAA/GATGTT 2 -- us2k10--------
    rs16135921,2
    		C,F,H,--57424000(+) TATCTT/GAGTCT 2 -- us2k124Minor allele frequency- G:0.29NS EA NA WA CSA 2352

    HapMap Linkage Disequilibrium report for CLP1 (57416465 - 57429340 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CLP1
         1 CNV: 4744

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CLP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLP1 for disorders           About GeneDecksing

    OMIM gene information: 608757    OMIM disorders: --

    4 diseases for CLP1:    About MalaCards
    monocytic leukemia    acute monocytic leukemia    leukemia    malaria

    1 disease from the University of Copenhagen DISEASES database for CLP1:
    Acute monocytic leukemia

    Export disorders for CLP1 gene to outside databases

    Publications
    for CLP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLP1 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CLP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. (PubMed id 11060040)1, 2, 3 de Vries H....Keller W. (2000)
    2. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12). (PubMed id 8896421)1, 2, 3 Tanabe S.... Rowley J.D. (1996)
    3. Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. (PubMed id 18648070)1, 2, 9 Ramirez A....Schwer B. (2008)
    4. The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. (PubMed id 17495927)1, 2, 9 Weitzer S. and Martinez J. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2 Paushkin S.V....Trotta C.R. (2004)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    External Searches for CLP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    NCBI Bookshelf
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    Genome Databases showing CLP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10978 HGNC: 16999 AceView: HEAB Ensembl:ENSG00000172409 euGenes: HUgn10978
    ECgene: CLP1 Kegg: 10978 H-InvDB: CLP1

    Other Databases showing CLP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLP1 gene:
    Search GeneIP for patents involving CLP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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