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Aliases for CLOCK Gene

Aliases for CLOCK Gene

  • Clock Circadian Regulator 2 3
  • Class E Basic Helix-Loop-Helix Protein 8 3 4
  • EC 2.3.1.48 4 63
  • BHLHe8 3 4
  • Circadian Locomoter Output Cycles Kaput Protein 3
  • Circadian Locomoter Output Cycles Protein Kaput 3
  • Clock (Mouse) Homolog 2
  • Clock Homolog (Mouse) 2
  • Clock Homolog 3
  • KIAA0334 4
  • KAT13D 3
  • HCLOCK 4

External Ids for CLOCK Gene

Previous GeneCards Identifiers for CLOCK Gene

  • GC04M056102
  • GC04M056260
  • GC04M056214
  • GC04M056139
  • GC04M055988
  • GC04M056294
  • GC04M052247

Summaries for CLOCK Gene

Entrez Gene Summary for CLOCK Gene

  • The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CLOCK Gene

CLOCK (Clock Circadian Regulator) is a Protein Coding gene. Diseases associated with CLOCK include delayed sleep phase syndrome and narcolepsy. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for CLOCK Gene

  • Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.

Gene Wiki entry for CLOCK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLOCK Gene

Genomics for CLOCK Gene

Regulatory Elements for CLOCK Gene

Genomic Location for CLOCK Gene

Start:
55,427,901 bp from pter
End:
55,547,138 bp from pter
Size:
119,238 bases
Orientation:
Minus strand

Genomic View for CLOCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLOCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLOCK Gene

Proteins for CLOCK Gene

  • Protein details for CLOCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15516-CLOCK_HUMAN
    Recommended name:
    Circadian locomoter output cycles protein kaput
    Protein Accession:
    O15516
    Secondary Accessions:
    • A0AV01
    • A2I2N9
    • O14516
    • Q9UIT8

    Protein attributes for CLOCK Gene

    Size:
    846 amino acids
    Molecular mass:
    95304 Da
    Quaternary structure:
    • Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ID1, ID3, MTA1, CIPC, RELA/p65, EIF4E, PIWIL1, DDX4, MGEA5, SIRT1, PER1, CRY2 and EZH2. Interacts with KMT2A in a circadian manner (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNTL/BMAL1 and this heterodimerization is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and for phosphorylation of both CLOCK and ARNTL/BMAL1. Interacts with NR3C1 in a ligand-dependent fashion. Interacts with ESR1 and estrogen stimulates this interaction. Interacts with the complex p35/CDK5. Interacts with KAT2B, CREBBP, EP300 and ID2. Interacts with PER2 and CRY1 and the interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA. The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B. Interacts with KDM5A. Interacts with MYBBP1A (By similarity). Interacts with THRAP3 (By similarity). Interacts with MED1; this interaction requires the presence of THRAP3 (By similarity). Interacts with NCOA2 (By similarity).
    Miscellaneous:
    • CLOCK-ARNTL/BMAL1 double mutations within the PAS domains result in synergistic desensitization to high levels of CRY on repression of CLOCK-ARNTL/BMAl1 transcriptional activity of PER1 and disrupt circadian rhythmicity
    SequenceCaution:
    • Sequence=BAA20792.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLOCK Gene

neXtProt entry for CLOCK Gene

Proteomics data for CLOCK Gene at MOPED

Post-translational modifications for CLOCK Gene

  • O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2.
  • Phosphorylation is dependent on the CLOCK-ARNTL/BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver. May be phosphorylated by CSNK1D and CKSN1E.
  • Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity. Sumoylation stimulates cell proliferation and increases the proportion of S phase cells in breast cancer cell lines.
  • Ubiquitinated, leading to its proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLOCK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CLOCK Gene

Gene Families for CLOCK Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins
  • KAT :Chromatin-modifying enzymes / K-acetyltransferases

Suggested Antigen Peptide Sequences for CLOCK Gene

Graphical View of Domain Structure for InterPro Entry

O15516

UniProtKB/Swiss-Prot:

CLOCK_HUMAN :
  • O15516
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with CLOCK: view

Function for CLOCK Gene

Molecular function for CLOCK Gene

GENATLAS Biochemistry: CLOCK gene,homolog to murine Clock,regulator of circadian rhythms,with two major transcripts 8 and 10kb,predominantly expressed in the suprachiasmatic nuclei and cerebellum
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot EnzymeRegulation: The redox state of the cell can modulate the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer; NADH and NADPH enhance the DNA-binding activity of the heterodimer.
UniProtKB/Swiss-Prot Function: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.

Enzyme Numbers (IUBMB) for CLOCK Gene

Gene Ontology (GO) - Molecular Function for CLOCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 18411297
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity ISS --
GO:0001046 core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding ISS --
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription ISS --
genes like me logo Genes that share ontologies with CLOCK: view
genes like me logo Genes that share phenotypes with CLOCK: view

Animal Models for CLOCK Gene

MGI Knock Outs for CLOCK:
Targeting motifs for CLOCK Gene
HOMER Transcription Factor Regulatory Elements motif CLOCK
  • Consensus sequence: GHCACGTG Submotif: canonical Cell Type: Liver GeoId: GSE39860

No data available for Transcription Factor Targeting for CLOCK Gene

Localization for CLOCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLOCK Gene

Nucleus. Cytoplasm. Note=Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL/BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250 UniProtKB:O08785, ECO:0000269 PubMed:21659603}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLOCK Gene COMPARTMENTS Subcellular localization image for CLOCK gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CLOCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14645221
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 9576906
GO:0005694 chromosome IDA 21659603
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CLOCK: view

Pathways for CLOCK Gene

genes like me logo Genes that share pathways with CLOCK: view

Gene Ontology (GO) - Biological Process for CLOCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10198158
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with CLOCK: view

Compounds for CLOCK Gene

(2) HMDB Compounds for CLOCK Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0

(6) Novoseek inferred chemical compound relationships for CLOCK Gene

Compound -log(P) Hits PubMed IDs
arylalkylamine 54.8 1
melatonin 46 1
fluvoxamine 41.3 3
dopamine 3.55 2
oxygen 0 1

(2) PharmGKB related drug/compound annotations for CLOCK Gene

Drug/compound Annotation
lithium CA
salbutamol CA
genes like me logo Genes that share compounds with CLOCK: view

Transcripts for CLOCK Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CLOCK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for CLOCK Gene

GeneLoc Exon Structure for
CLOCK
ECgene alternative splicing isoforms for
CLOCK

Expression for CLOCK Gene

mRNA expression in normal human tissues for CLOCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLOCK Gene

SOURCE GeneReport for Unigene cluster for CLOCK Gene Hs.436975

mRNA Expression by UniProt/SwissProt for CLOCK Gene

O15516-CLOCK_HUMAN
Tissue specificity: Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).
genes like me logo Genes that share expressions with CLOCK: view

No data available for mRNA differential expression in normal tissues for CLOCK Gene

Orthologs for CLOCK Gene

This gene was present in the common ancestor of animals.

Orthologs for CLOCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLOCK 35
  • 99.41 (n)
  • 99.53 (a)
CLOCK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLOCK 35
  • 92.34 (n)
  • 96.09 (a)
CLOCK 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLOCK 35
  • 92.83 (n)
  • 96.69 (a)
CLOCK 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clock 35
  • 90.84 (n)
  • 96.43 (a)
Clock 16
Clock 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLOCK 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLOCK 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clock 35
  • 89.46 (n)
  • 94.89 (a)
chicken
(Gallus gallus)
Aves CLOCK 35
  • 80.81 (n)
  • 85.9 (a)
CLOCK 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLOCK 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.566 35
tropical clawed frog
(Silurana tropicalis)
Amphibia clock 35
  • 74.73 (n)
  • 79.95 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11889 35
zebrafish
(Danio rerio)
Actinopterygii clock 35
  • 65.57 (n)
  • 72.84 (a)
clock 36
  • 68 (a)
OneToMany
clock3 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Clk 36
  • 30 (a)
OneToMany
Clk 37
  • 50 (a)
Species with no ortholog for CLOCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLOCK Gene

ENSEMBL:
Gene Tree for CLOCK (if available)
TreeFam:
Gene Tree for CLOCK (if available)

Paralogs for CLOCK Gene

Paralogs for CLOCK Gene

Selected SIMAP similar genes for CLOCK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLOCK: view

Variants for CLOCK Gene

Sequence variations from dbSNP and Humsavar for CLOCK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs5863 -- 55,430,740(-) AGTGA(C/T)TGCTA utr-variant-3-prime
rs11240 -- 55,453,183(+) AAATA(C/G)TGCAC intron-variant
rs931395 -- 55,543,853(-) ACTTA(C/T)TTTTC intron-variant
rs939823 -- 55,487,368(+) cttta(C/T)tgtag intron-variant
rs960152 -- 55,467,308(+) CAAAT(A/C)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLOCK Gene

Variant ID Type Subtype PubMed ID
esv5988 CNV Gain 19470904
esv2727633 CNV Deletion 23290073
dgv888e201 CNV Deletion 23290073
esv2661534 CNV Deletion 23128226
nsv10496 CNV Loss 18304495
esv269816 CNV Insertion 20981092
esv273628 CNV Insertion 20981092
esv1694176 CNV Insertion 17803354

Relevant External Links for CLOCK Gene

HapMap Linkage Disequilibrium report
CLOCK
Human Gene Mutation Database (HGMD)
CLOCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLOCK Gene

Disorders for CLOCK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CLOCK Gene including...

Search for CLOCK Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLOCK Gene

(10) Novoseek inferred disease relationships for CLOCK Gene

Disease -log(P) Hits PubMed IDs
delayed sleep phase syndrome 75 1
bipolar disorder 48.7 4
narcolepsy 41.7 2
major depression 39.4 5
mood disorders 33.8 4

Relevant External Links for CLOCK

Genetic Association Database (GAD)
CLOCK
Human Genome Epidemiology (HuGE) Navigator
CLOCK
genes like me logo Genes that share disorders with CLOCK: view

No data available for UniProtKB/Swiss-Prot for CLOCK Gene

Publications for CLOCK Gene

  1. Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. (PMID: 10198158) Steeves T.D.L. … Takahashi J.S. (Genomics 1999) 2 3 4 23
  2. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. (PMID: 11441146) Rutter J. … McKnight S.L. (Science 2001) 3 4 23
  3. A CLOCK polymorphism associated with human diurnal preference. (PMID: 9779516) Katzenberg D. … Mignot E. (Sleep 1998) 3 23 48
  4. Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. (PMID: 12898572) Serretti A. … Smeraldi E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48
  5. Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. (PMID: 14582141) Benedetti F. … Smeraldi E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48

Products for CLOCK Gene

Sources for CLOCK Gene

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