Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLNK Gene

protein-coding   GIFtS: 50
GCID: GC04M010491

Cytokine-Dependent Hematopoietic Cell Linker

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytokine-Dependent Hematopoietic Cell Linker1 2
Mast Cell Immunoreceptor Signal Transducer1 2 3
MIST2 3

External Ids:    HGNC: 174381   Entrez Gene: 1164492   Ensembl: ENSG000001096847   OMIM: 6114345   UniProtKB: Q7Z7G13   

Export aliases for CLNK gene to outside databases

Previous GC identifers: GC04M010100 GC04M009825


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLNK Gene:
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in
the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen
receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al.,
1999 (PubMed 10562326); Goitsuka et al., 2000, 2001 (PubMed 10744659) (PubMed 11463797)).(supplied by OMIM, Mar
2008)

GeneCards Summary for CLNK Gene: 
CLNK (cytokine-dependent hematopoietic cell linker) is a protein-coding gene. Diseases associated with CLNK include croup, and eastern equine encephalitis. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is BLNK.

UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1
Function: Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen
receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLNK gene promoter:
         GR   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   Evi-1   HNF-4alpha1   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLNK promoter sequence
   Search SABiosciences Chromatin IP Primers for CLNK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLNK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

CLNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLNK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M010491:  view genomic region     (about GC identifiers)

Start:
10,488,019 bp from pter      End:
10,686,489 bp from pter
Size:
198,471 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1 (See protein sequence)
Recommended Name: Cytokine-dependent hematopoietic cell linker  
Size: 428 amino acids; 49554 Da
Subunit: When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT (By similarity)
Secondary accessions: Q05C27 Q9P2U9
Alternative splicing: 3 isoforms:  Q7Z7G1-1   Q7Z7G1-2   Q7Z7G1-3   

Explore the universe of human proteins at neXtProt for CLNK: NX_Q7Z7G1

Explore proteomics data for CLNK at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required
    for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40
    cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1
    via phosphorylated Tyr-96 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7G1

  • CLNK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLNK Protein Expression
    REFSEQ proteins: NP_443196.2  
    ENSEMBL proteins: 
     ENSP00000226951   ENSP00000427256   ENSP00000427208   ENSP00000390744  

    Human Recombinant Protein Products for CLNK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CLNK
    OriGene Protein Over-expression Lysate for CLNK
    OriGene MassSpec for CLNK 
    OriGene Custom Protein Services for CLNK
    GenScript Custom Purified and Recombinant Proteins Services for CLNK
    Novus Biologicals CLNK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10744659

    CLNK for ontologies           About GeneDecksing



    CLNK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLNK
    GenScript Custom Superior Antibodies Services for CLNK
    Novus Biologicals CLNK Antibodies
    Abcam antibodies for CLNK
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CLNK
    LSBio Antibodies in human, mouse, rat for CLNK 

    Assay Products for CLNK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLNK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLNK
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    1 InterPro protein domain:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q7Z7G1

    ProtoNet protein and cluster: Q7Z7G1

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1
    Domain: The N-terminal proline-rich region interacts with the SH3 domain of PLCG1 (By similarity)
    Domain: The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in
    BLNK-deficient DT40 cells expressing LAT (By similarity)
    Similarity: Contains 1 SH2 domain


    CLNK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLNK_HUMAN, Q7Z7G1
    Function: Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen
    receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity NAS10744659
    GO:0005515protein binding IPI16273093
         
    CLNK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLNK:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clnk):
     hematopoietic system  immune system 

    CLNK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clnktm1Vei for CLNK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLNK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLNK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLNK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLNK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLNK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLNK
    SwitchGear 3'UTR luciferase reporter plasmidCLNK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLNK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLNK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLNK
    Sirion Biotech Customized adenovirus for overexpression of CLNK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLNK (see all 6)
    OriGene ORF clones in mouse, rat for CLNK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLNK (NM_052964)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLNK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLNK
    Sirion Biotech Customized lentivirus for stable overexpression of CLNK 
                         Customized lentivirus expression plasmids for stable overexpression of CLNK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLNK
    Search LifeMap BioReagents cell lines for CLNK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLNK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLNK

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for CLNK (Q7Z7G12, 3 ENSP000002269514) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74585 MINT-74586 I2D: score=1 STRING: ENSP00000269571
    EGFRP005332, 3, ENSP000002754934MINT-74583 MINT-74584 I2D: score=1 STRING: ENSP00000275493
    FYBO151173, ENSP000003164604I2D: score=1 STRING: ENSP00000316460
    LCP2Q130943, ENSP000000467944I2D: score=1 STRING: ENSP00000046794
    SKAP2O755633, ENSP000000055874I2D: score=1 STRING: ENSP00000005587
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS10744659
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0035556intracellular signal transduction IDA10744659

    CLNK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLNK

    1 HMDB Compound for CLNK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CLNK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLNK gene: 
    NM_052964.2  

    Unigene Cluster for CLNK:

    Cytokine-dependent hematopoietic cell linker
    Hs.678910  [show with all ESTs]
    Unigene Representative Sequence: AK093001
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226951(uc003gmo.4) ENST00000515667 ENST00000507719(uc003gmp.3)
    ENST00000442825
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLNK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CLNK
    SwitchGear 3'UTR luciferase reporter plasmidCLNK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLNK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLNK
    Clone
    Products:
         
    OriGene clones in human, mouse for CLNK (see all 6)
    OriGene ORF clones in mouse, rat for CLNK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLNK (NM_052964)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLNK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLNK
    Sirion Biotech Customized lentivirus for stable overexpression of CLNK 
                         Customized lentivirus expression plasmids for stable overexpression of CLNK 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLNK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLNK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLNK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLNK

    Additional mRNA sequence: 

    AB032369.1 AB110420.1 AK093001.1 BC029887.1 BC137553.1 BC137556.1 

    4 DOTS entries:

    DT.100696937  DT.121218464  DT.91923853  DT.91978204 

    8 AceView cDNA sequences:

    BC029887 BI829736 AK093001 NM_052964 AB110420 AX747849 BX489472 AB032369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLNK expression in normal human tissues (normalized intensities)      CLNK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLNK Expression
    About this image


    CLNK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Natural Killer Cells Peripheral Blood
             CD19+ B Cells   
             clps   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See CLNK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLNK

    SOURCE GeneReport for Unigene cluster: Hs.678910
        SABiosciences Custom PCR Arrays for CLNK
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CLNK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLNK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLNK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLNK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLNK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CLNK gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clnk1 , 5 cytokine-dependent hematopoietic cell linker1, 5 75.26(n)1
    62.88(a)1
      5 (20.81 cM)5
    272781  NM_013748.31  NP_038776.31 
     387064575 
    zebrafish
    (Danio rerio)
    Actinopterygii CLNK6
    cytokine-dependent hematopoietic cell linker
    20(a)
    1 ↔ 1
    14(256879-261961)


    ENSEMBL Gene Tree for CLNK (if available)
    TreeFam Gene Tree for CLNK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLNK gene
    BLNK2  LCP22  SH2D62  
    2 SIMAP similar genes for CLNK using alignment to 2 protein entries:     CLNK_HUMAN (see all proteins):
    LCP2    PTPN11

    CLNK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4618 SNPs in CLNK are shown (see all 4618)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117367541,2
    C,F,H--10491351(+) AGTGGT/CGCGAT 1 -- int1 ese32Minor allele frequency- C:0.33NA 6
    rs1924753361,2
    --10491354(+) GGCGCA/GATTTC 1 -- int10--------
    rs117254111,2
    C,F,A,H--10491357(+) GCGATC/TTCGGC 1 -- int12Minor allele frequency- T:0.33NA 6
    rs117282261,2
    C,F,H--10491384(+) CTCCCA/GGGTTC 1 -- int1 ese35Minor allele frequency- G:0.25NA WA 12
    rs361707991,2
    C--10491452(+) CGCCCG/AGCTGA 1 -- int16Minor allele frequency- A:0.09NA WA CSA 11
    rs1388442671,2
    C--10491477(+) AGTAGA/TCATGG 1 -- int10--------
    rs1873120271,2
    --10491511(+) GGTCTC/TGATCT 1 -- int10--------
    rs131216261,2
    C,F--10491551(+) TCCCAC/AAGTGC 1 -- int16Minor allele frequency- A:0.17NA WA CSA 12
    rs131273041,2
    C,F,H--10491627(+) TTGTAG/TATATG 1 -- int1 ese313Minor allele frequency- T:0.39EA NS NA WA CSA 620
    rs131273061,2
    C,F--10491631(+) ATATAG/TGTAAG 1 -- int1 ese313Minor allele frequency- T:0.37NA WA CSA EA 496

    HapMap Linkage Disequilibrium report for CLNK (10488019 - 10686489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for CLNK (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2797CNV Deletion18987735
    esv2727176CNV Deletion23290073
    esv2727177CNV Deletion23290073
    esv2664970CNV Deletion23128226
    nsv4234CNV Insertion18451855
    esv270477CNV Insertion20981092
    nsv525514CNV Loss19592680
    esv32732CNV Loss17666407
    nsv518387CNV Loss19592680
    nsv820003CNV Gain19587683


    Human Gene Mutation Database (HGMD): CLNK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLNK
    DNA2.0 Custom Variant and Variant Library Synthesis for CLNK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611434    OMIM disorders: --

    15 diseases for CLNK:    About MalaCards
    croup    eastern equine encephalitis    gingival recession    western equine encephalitis
    tracheitis    epiglottitis    patent foramen ovale    legionnaires' disease
    encephalitis    gingivitis    bronchitis    vitiligo
    migraine    chronic obstructive pulmonary disease    cystic fibrosis

    5 diseases from the University of Copenhagen DISEASES database for CLNK:
    Patent foramen ovale     Croup     Gingival recession     Chronic obstructive pulmonary disease
    Migraine

    CLNK for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLNK
    Human Genome Epidemiology (HuGE) Navigator: CLNK (3 documents)

    Export disorders for CLNK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLNK gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CLNK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PubMed id 10744659)1, 2, 3 Goitsuka R.... Kitamura D. (2000)
    2. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PubMed id 10562326)1, 3 Cao M.Y....Veillette A. (1999)
    3. Genome-wide association analyses identify 13 new susce ptibility loci for generalized vitiligo. (PubMed id 22561518)1 Jin Y....Spritz R.A. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1 Cronin S....Hardiman O. (2008)
    6. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
    9. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)4 Schymick J.C....Traynor B.J. (2007)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116449 HGNC: 17438 AceView: MIST Ensembl:ENSG00000109684 euGenes: HUgn116449
    ECgene: CLNK H-InvDB: CLNK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLNK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLNK gene:
    Search GeneIP for patents involving CLNK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CLNK  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CLNK  
     OriGene MassSpec something-or-other for CLNK   OriGene clones in human, mouse for CLNK  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLNK   OriGene Purified Protein for CLNK  
     OriGene ORF clones in mouse, rat for CLNK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLNK   OriGene Custom Protein Services for CLNK  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLNK
     QIAGEN SeqTarget long-range PCR primers for resequencing CLNK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLNK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLNK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLNK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLNK
     GenScript Custom Purified and Recombinant Proteins Services for CLNK GenScript cDNA clones with any tag delivered in your preferred vector for CLNK
     GenScript Custom Assay Services for CLNK GenScript Custom Superior Antibodies Services for CLNK
     GenScript Custom overexpressing Cell Line Services for CLNK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLNK promoter
     Search Chromatin IP Primers for CLNK
     RT2 qPCR Primer Assay in human, mouse, rat CLNK
     Search GNC Networks for CLNK
     SABiosciences Custom PCR Arrays for CLNK
     Search Tocris compounds for CLNK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLNK antibodies
     CLNK lysates
     Antibodies for CLNK
     See all of Abcam's Antibodies, Kits and Proteins for CLNK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CLNK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLNK
     SwitchGear 3'UTR luciferase reporter plasmids for CLNK
     SwitchGear Promoter luciferase reporter plasmids for CLNK
     Search ThermoFisher Antibodies for CLNK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLNK
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLNK
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLNK
    Customized:
     lentivirus for stable overexpression of CLNK
     lentivirus expression plasmids for stable overexpression of CLNK
     adenovirus for overexpression of CLNK
     LSBio Antibodies in human, mouse, rat for CLNK
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLNK gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4