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CLNK Gene

protein-coding   GIFtS: 48
GCID: GC04M010491

Cytokine-Dependent Hematopoietic Cell Linker

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytokine-Dependent Hematopoietic Cell Linker1 2
Mast Cell Immunoreceptor Signal Transducer1 2 3
MIST2 3

External Ids:    HGNC: 174381   Entrez Gene: 1164492   Ensembl: ENSG000001096847   OMIM: 6114345   UniProtKB: Q7Z7G13   

Export aliases for CLNK gene to outside databases

Previous GC identifers: GC04M010100 GC04M009825


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLNK Gene:
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in
the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen
receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al.,
1999 (PubMed 10562326); Goitsuka et al., 2000, 2001 (PubMed 10744659) (PubMed 11463797)).(supplied by OMIM, Mar
2008)

GeneCards Summary for CLNK Gene:
CLNK (cytokine-dependent hematopoietic cell linker) is a protein-coding gene. Diseases associated with CLNK include western equine encephalitis, and tracheitis. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is BLNK.

UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1
Function: Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen
receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CLNK gene promoter:
         GR   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   Evi-1   HNF-4alpha1   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLNK promoter sequence
   Search Chromatin IP Primers for CLNK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLNK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

CLNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLNK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M010491:  view genomic region     (about GC identifiers)

Start:
10,488,019 bp from pter      End:
10,686,489 bp from pter
Size:
198,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1 (See protein sequence)
Recommended Name: Cytokine-dependent hematopoietic cell linker  
Size: 428 amino acids; 49554 Da
Subunit: When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT (By similarity)
Secondary accessions: Q05C27 Q9P2U9
Alternative splicing: 3 isoforms:  Q7Z7G1-1   Q7Z7G1-2   Q7Z7G1-3   

Explore the universe of human proteins at neXtProt for CLNK: NX_Q7Z7G1

Explore proteomics data for CLNK at MOPED

Post-translational modifications: 

  • Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required
    for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40
    cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1
    via phosphorylated Tyr-96 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLNK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443196.2  
    ENSEMBL proteins: 
     ENSP00000226951   ENSP00000427256   ENSP00000427208   ENSP00000390744  

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    Browse Proteins at Cloud-Clone Corp.

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    1 InterPro protein domain:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q7Z7G1

    ProtoNet protein and cluster: Q7Z7G1

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: CLNK_HUMAN, Q7Z7G1
    Domain: The N-terminal proline-rich region interacts with the SH3 domain of PLCG1 (By similarity)
    Domain: The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in
    BLNK-deficient DT40 cells expressing LAT (By similarity)
    Similarity: Contains 1 SH2 domain


    CLNK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLNK_HUMAN, Q7Z7G1
    Function: Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen
    receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity NAS10744659
    GO:0005515protein binding IPI16273093
         
    CLNK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLNK:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clnk):
     hematopoietic system  immune system 

    CLNK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clnktm1Vei for CLNK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLNK
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLNK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10744659

    CLNK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLNK
    Interactions:

        Search GeneGlobe Interaction Network for CLNK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CLNK (Q7Z7G11, 2, 3 ENSP000002269514) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-7878194,EBI-641062 MINT-74585 MINT-74586 I2D: score=1 STRING: ENSP00000269571
    EGFRP005331, 2, 3, ENSP000002754934EBI-7878194,EBI-297353 MINT-74583 MINT-74584 I2D: score=1 STRING: ENSP00000275493
    FYBO151173, ENSP000003164604I2D: score=1 STRING: ENSP00000316460
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    LCP2Q130943, ENSP000000467944I2D: score=1 STRING: ENSP00000046794
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS10744659
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0009967positive regulation of signal transduction NAS10744659
    GO:0035556intracellular signal transduction IDA10744659

    CLNK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLNK

    1 HMDB Compound for CLNK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLNK gene: 
    NM_052964.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226951(uc003gmo.4) ENST00000515667 ENST00000507719(uc003gmp.3)
    ENST00000442825
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CLNK
      QuantiFast Probe-based Assays in human, mouse, rat CLNK

    8 AceView cDNA sequences:

    BI829736 BC029887 NM_052964 AB110420 BX489472 AB032369 AK093001 AX747849 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLNK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLNK Expression
    About this image


    CLNK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    CLNK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLNK Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLNK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLNK gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clnk1 , 5 cytokine-dependent hematopoietic cell linker1, 5 75.26(n)1
    62.88(a)1
      5 (20.81 cM)5
    272781  NM_013748.31  NP_038776.31 
     387064575 
    chicken
    (Gallus gallus)
    Aves SLP766
    Gallus gallus lymphocyte cytosolic protein 2 (SH2 ...
    20(a)
    many ↔ many
    13(3218332-3252473)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    18(a)
    many ↔ many
    2(120665280-120707798)
    zebrafish
    (Danio rerio)
    Actinopterygii CLNK6
    cytokine-dependent hematopoietic cell linker
    22(a)
    1 ↔ 1
    14(256879-261961) ENSDARG00000091321


    ENSEMBL Gene Tree for CLNK (if available)
    TreeFam Gene Tree for CLNK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLNK gene
    BLNK2  LCP22  SH2D62  
    2 SIMAP similar genes for CLNK using alignment to 2 protein entries:     CLNK_HUMAN (see all proteins):
    LCP2    PTPN11

    CLNK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLNK (see all 4618)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117367541,2
    C,F,H--10491351(+) AGTGGT/CGCGAT 1 -- int1 ese32Minor allele frequency- C:0.33NA 6
    rs1924753361,2
    --10491354(+) GGCGCA/GATTTC 1 -- int10--------
    rs117254111,2
    C,F,A,H--10491357(+) GCGATC/TTCGGC 1 -- int12Minor allele frequency- T:0.33NA 6
    rs117282261,2
    C,F,H--10491384(+) CTCCCA/GGGTTC 1 -- int1 ese35Minor allele frequency- G:0.25NA WA 12
    rs361707991,2
    C--10491452(+) CGCCCG/AGCTGA 1 -- int16Minor allele frequency- A:0.09NA WA CSA 11
    rs1388442671,2
    C--10491477(+) AGTAGA/TCATGG 1 -- int10--------
    rs1873120271,2
    --10491511(+) GGTCTC/TGATCT 1 -- int10--------
    rs131216261,2
    C,F--10491551(+) TCCCAC/AAGTGC 1 -- int16Minor allele frequency- A:0.17NA WA CSA 12
    rs131273041,2
    C,F,H--10491627(+) TTGTAG/TATATG 1 -- int1 ese313Minor allele frequency- T:0.39EA NS NA WA CSA 620
    rs131273061,2
    C,F--10491631(+) ATATAG/TGTAAG 1 -- int1 ese313Minor allele frequency- T:0.37NA WA CSA EA 496

    HapMap Linkage Disequilibrium report for CLNK (10488019 - 10686489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CLNK (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2797CNV Deletion18987735
    esv2727176CNV Deletion23290073
    esv2727177CNV Deletion23290073
    esv2664970CNV Deletion23128226
    nsv4234CNV Insertion18451855
    esv270477CNV Insertion20981092
    nsv525514CNV Loss19592680
    esv32732CNV Loss17666407
    nsv518387CNV Loss19592680
    nsv820003CNV Gain19587683

    Human Gene Mutation Database (HGMD): CLNK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLNK
    DNA2.0 Custom Variant and Variant Library Synthesis for CLNK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611434    OMIM disorders: --

    16 diseases for CLNK:    
    About MalaCards
    western equine encephalitis    tracheitis    croup    epiglottitis
    gingival recession    eastern equine encephalitis    patent foramen ovale    legionnaires' disease
    encephalitis    gingivitis    bronchitis    vitiligo
    migraine    amyotrophic lateral sclerosis    lateral sclerosis    cystic fibrosis

    5 diseases from the University of Copenhagen DISEASES database for CLNK:
    Patent foramen ovale     Croup     Gingival recession     Chronic obstructive pulmonary disease
    Migraine

    CLNK for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLNK
    Human Genome Epidemiology (HuGE) Navigator: CLNK (3 documents)

    Export disorders for CLNK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLNK gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CLNK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PubMed id 10744659)1, 2, 3 Goitsuka R.... Kitamura D. (Int. Immunol. 2000)
    2. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PubMed id 10562326)1, 3 Cao M.Y....Veillette A. (J. Exp. Med. 1999)
    3. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. (PubMed id 22561518)1 Jin Y....Spritz R.A. (Nat. Genet. 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1 Cronin S....Hardiman O. (Eur. J. Hum. Genet. 2009)
    6. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    9. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)4 Schymick J.C....Traynor B.J. (Lancet Neurol 2007)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116449 HGNC: 17438 AceView: MIST Ensembl:ENSG00000109684 euGenes: HUgn116449
    ECgene: CLNK H-InvDB: CLNK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLNK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLNK gene:
    Search GeneIP for patents involving CLNK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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