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Aliases for CLNK Gene

Aliases for CLNK Gene

  • Cytokine Dependent Hematopoietic Cell Linker 2 3 5
  • Mast Cell Immunoreceptor Signal Transducer 2 3 4
  • MIST 3 4
  • Cytokine-Dependent Hematopoietic Cell Linker 3

External Ids for CLNK Gene

Previous GeneCards Identifiers for CLNK Gene

  • GC04M010100
  • GC04M009825

Summaries for CLNK Gene

Entrez Gene Summary for CLNK Gene

  • MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CLNK Gene

CLNK (Cytokine Dependent Hematopoietic Cell Linker) is a Protein Coding gene. Diseases associated with CLNK include Croup and Trichotillomania. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is LCP2.

UniProtKB/Swiss-Prot for CLNK Gene

  • Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLNK Gene

Genomics for CLNK Gene

Regulatory Elements for CLNK Gene

Enhancers for CLNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F010611 1 Ensembl ENCODE 11.8 +123.0 122959 1.4 JUN ZEB1 ZBTB48 ZNF366 PRDM10 FOS ZNF600 ZNF639 ZNF280D GFI1B ENSG00000249334 CLNK HS3ST1 LOC105374480 LOC105374481
GH04F010663 0.6 Ensembl ENCODE 11.9 +70.3 70333 1.4 JUN ENSG00000249334 CLNK ENSG00000261490 LOC105374480
GH04F010640 0.6 Ensembl ENCODE 11.7 +94.1 94053 1.2 ETV6 ENSG00000249334 CLNK LOC105374480
GH04F010732 0.6 ENCODE 0.8 +2.1 2102 0.2 STAT1 MTA2 ZBED1 CBFB TRIM22 TBX21 EP300 IKZF1 NBN CLNK ENSG00000249334
GH04F010726 0.6 ENCODE 0.4 +7.6 7561 1.1 PKNOX1 MTA2 BMI1 EBF1 TBX21 RELA IKZF1 MLLT1 SPI1 CLNK ENSG00000249334
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLNK on UCSC Golden Path with GeneCards custom track

Genomic Location for CLNK Gene

Chromosome:
4
Start:
10,486,395 bp from pter
End:
10,734,853 bp from pter
Size:
248,459 bases
Orientation:
Minus strand

Genomic View for CLNK Gene

Genes around CLNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLNK Gene

Proteins for CLNK Gene

  • Protein details for CLNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7G1-CLNK_HUMAN
    Recommended name:
    Cytokine-dependent hematopoietic cell linker
    Protein Accession:
    Q7Z7G1
    Secondary Accessions:
    • Q05C27
    • Q9P2U9

    Protein attributes for CLNK Gene

    Size:
    428 amino acids
    Molecular mass:
    49554 Da
    Quaternary structure:
    • When phosphorylated, interacts with PLCG1, PLCG2, GRB2, VAV and LAT.

    Alternative splice isoforms for CLNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLNK Gene

Post-translational modifications for CLNK Gene

  • Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLNK Gene

No data available for DME Specific Peptides for CLNK Gene

Domains & Families for CLNK Gene

Gene Families for CLNK Gene

Protein Domains for CLNK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7G1

UniProtKB/Swiss-Prot:

CLNK_HUMAN :
  • The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
Domain:
  • The N-terminal proline-rich region interacts with the SH3 domain of PLCG1.
  • The SH2 domain is important for restoration of BCR-induced calcium response and JNK2 activation in BLNK-deficient DT40 cells expressing LAT.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with CLNK: view

Function for CLNK Gene

Molecular function for CLNK Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).

Gene Ontology (GO) - Molecular Function for CLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity NAS 10744659
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with CLNK: view
genes like me logo Genes that share phenotypes with CLNK: view

Animal Models for CLNK Gene

MGI Knock Outs for CLNK:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLNK

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLNK Gene

Localization for CLNK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLNK gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10744659
genes like me logo Genes that share ontologies with CLNK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CLNK Gene

Pathways & Interactions for CLNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10744659
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IDA 10744659
genes like me logo Genes that share ontologies with CLNK: view

No data available for Pathways by source and SIGNOR curated interactions for CLNK Gene

Drugs & Compounds for CLNK Gene

(1) Drugs for CLNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLNK: view

Transcripts for CLNK Gene

mRNA/cDNA for CLNK Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CLNK Gene

Cytokine-dependent hematopoietic cell linker:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLNK Gene

No ASD Table

Relevant External Links for CLNK Gene

GeneLoc Exon Structure for
CLNK
ECgene alternative splicing isoforms for
CLNK

Expression for CLNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLNK Gene

This gene is overexpressed in Kidney - Cortex (x12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLNK Gene



NURSA nuclear receptor signaling pathways regulating expression of CLNK Gene:

CLNK

SOURCE GeneReport for Unigene cluster for CLNK Gene:

Hs.678910
genes like me logo Genes that share expression patterns with CLNK: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CLNK Gene

Orthologs for CLNK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLNK 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia CLNK 34 35
  • 81.45 (n)
dog
(Canis familiaris)
Mammalia CLNK 34 35
  • 81.38 (n)
rat
(Rattus norvegicus)
Mammalia Clnk 34
  • 75.53 (n)
mouse
(Mus musculus)
Mammalia Clnk 34 16 35
  • 75.26 (n)
oppossum
(Monodelphis domestica)
Mammalia CLNK 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLP76 35
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CLNK 35
  • 22 (a)
OneToOne
Species where no ortholog for CLNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLNK Gene

ENSEMBL:
Gene Tree for CLNK (if available)
TreeFam:
Gene Tree for CLNK (if available)

Paralogs for CLNK Gene

Paralogs for CLNK Gene

(2) SIMAP similar genes for CLNK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CLNK: view

Variants for CLNK Gene

Sequence variations from dbSNP and Humsavar for CLNK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000059 -- 10,720,715(+) caagg(A/C)tatgt intron-variant
rs10000248 -- 10,720,872(+) acaaa(A/G)attgg intron-variant
rs10001632 -- 10,520,247(+) GTGAT(A/C)TCCTT intron-variant
rs10001979 -- 10,720,244(+) aaaaa(C/T)caatg intron-variant
rs10002387 -- 10,720,648(+) AGAGA(C/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLNK Gene

Variant ID Type Subtype PubMed ID
nsv829860 CNV gain 17160897
nsv829858 CNV gain+loss 17160897
nsv820003 CNV gain 19587683
nsv593727 CNV gain 21841781
nsv527914 CNV gain 19592680
nsv525514 CNV loss 19592680
nsv518387 CNV loss 19592680
nsv517971 CNV gain 19592680
nsv472031 CNV novel sequence insertion 20440878
nsv4234 CNV insertion 18451855
nsv1132930 CNV insertion 24896259
nsv1117372 CNV tandem duplication 24896259
nsv1116399 CNV insertion 24896259
nsv1014335 CNV gain 25217958
esv3893877 CNV loss 25118596
esv3893876 CNV gain 25118596
esv3599628 CNV loss 21293372
esv3599627 CNV loss 21293372
esv3599626 CNV loss 21293372
esv3599625 CNV loss 21293372
esv3599624 CNV loss 21293372
esv3563417 CNV deletion 23714750
esv3414661 CNV insertion 20981092
esv3387645 CNV insertion 20981092
esv3341192 CNV insertion 20981092
esv3306200 CNV mobile element insertion 20981092
esv32732 CNV loss 17666407
esv2797 CNV loss 18987735
esv2759223 CNV loss 17122850
esv2727177 CNV deletion 23290073
esv2727176 CNV deletion 23290073
esv2664970 CNV deletion 23128226
dgv2935e59 CNV tandem duplication 20981092
dgv1463e212 CNV loss 25503493

Variation tolerance for CLNK Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLNK Gene

Human Gene Mutation Database (HGMD)
CLNK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLNK Gene

Disorders for CLNK Gene

MalaCards: The human disease database

(8) MalaCards diseases for CLNK Gene - From: DISEASES

Disorder Aliases PubMed IDs
croup
  • acute laryngotracheobronchitis
trichotillomania
  • hair-pulling syndrome
gingival recession
  • gingival recession nos
stereotypic movement disorder
  • stereotyped repetitive movements nos
impulse control disorder
  • disruptive, impulse control, and conduct disorders
- elite association - COSMIC cancer census association via MalaCards
Search CLNK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLNK

Genetic Association Database (GAD)
CLNK
Human Genome Epidemiology (HuGE) Navigator
CLNK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLNK
genes like me logo Genes that share disorders with CLNK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLNK Gene

Publications for CLNK Gene

  1. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. (PMID: 10744659) Goitsuka R. … Kitamura D. (Int. Immunol. 2000) 2 3 4 64
  2. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. (PMID: 10562326) Cao M.Y. … Veillette A. (J. Exp. Med. 1999) 2 3 64
  3. Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets. (PMID: 25591661) Jin T.B. … Kang L. (Rheumatol. Int. 2015) 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y. … Plenge R.M. (Nature 2013) 3 64

Products for CLNK Gene

Sources for CLNK Gene

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