CLN6 Gene
protein-coding GIFtS: 51
GCID: GC15M068499
|
|
ceroid-lipofuscinosis, neuronal 6, late infantile, variant
| |
Aliases
for CLN6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ceroid-Lipofuscinosis, Neuronal 6, Late Infantile, Variant1 2 | | CLN4A2 | | HsT189601 2 | | Ceroid-Lipofuscinosis Neuronal Protein 62 | | Nclf1 | | Protein CLN63 | | FLJ205611 | | |
Export aliases for CLN6 gene to outside databasesPrevious GC identifers: GC15M064339 GC15M061598 GC15M066063 GC15M066215 GC15M066286 GC15M045330 |
Summaries
for CLN6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLN6:
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to asBatten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. Thegenes responsible likely encode proteins involved in the degradation of post-translationally modified proteins inlysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. (providedby RefSeq, Oct 2008)
Gene Wiki entry for CLN6
|
Genomic Views
for CLN6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLN6 gene promoter:
Egr-3 Max1 RP58 GATA-3 Egr-1 Lmo2 E47 RORalpha2 AREB6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLN6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLN6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23CLN6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M068499: view genomic region
(about GC identifiers)
Start:
|
68,499,330 bp from pter |
End:
|
68,549,549 bp from pter |
Size:
|
50,220 bases |
Orientation:
|
minus strand |
|
Proteins
for CLN6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLN6_HUMAN, Q9NWW5 (See
protein sequence)Recommended Name: Ceroid-lipofuscinosis neuronal protein 6 Size: 311 amino acids; 35919 Da
Subunit: Interacts with CRMP2
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A8K560 Q6IAB1 Q96SR0Explore the universe of human proteins at neXtProt for CLN6: NX_Q9NWW5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWW5
CLN6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060352.1
ENSEMBL proteins: ENSP00000249806 ENSP00000457384 ENSP00000454818 ENSP00000457783 ENSP00000445770 ENSP00000457822 ENSP00000393826
Human Recombinant Protein Products for CLN6:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CLN6 for ontologies About GeneDecksing
CLN6 Antibody Products:
Assay Products for CLN6: |
Protein
Domains /
Families
for CLN6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NWW5 |
Function
for CLN6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CLN6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CLN6:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cln6):
CLN6 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLN6 (NM_017882) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLN6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLN6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLN6 |
|
Pathways & Interactions
for CLN6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLN6
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for CLN6 (Q9NWW53 ENSP000002498064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
CLN6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLN6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLN6 for compounds About GeneDecksing
 Browse Tocris compounds for CLN6
1 Novoseek chemical compound relationship for CLN6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lipid |
0 |
1 |
17237713 (1) |
Search CenterWatch for drugs/clinical trials and news about CLN6
|
Transcripts
for CLN6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLN6 gene: NM_017882.2 Unigene Cluster for CLN6: Ceroid-lipofuscinosis, neuronal 6, late infantile, variant Hs.584921 [show with all ESTs]Unigene Representative Sequence: NM_01788210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249806(uc002arf.3 uc010ujy.2 uc010ujz.2) ENST00000565471
ENST00000567060 ENST00000566347 ENST00000538696 ENST00000564752 ENST00000563917
ENST00000564846 ENST00000569336 ENST00000418702
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLN6 (NM_017882) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLN6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLN6 |
Additional cDNA sequence: AK000568.1 AK027604.1 AK074753.1 AK124013.1 AK291175.1 AK293155.1 AK293197.1 BC010849.1 BC013130.1 CR457244.1 16 DOTS entries: DT.97782925 DT.87016884 DT.91840980 DT.75194773 DT.100669373 DT.100795124 DT.121060538 DT.97824341 DT.100795125 DT.95129920 DT.99965500 DT.121060579 DT.121060780 DT.95129918 DT.121060643 DT.95105263 24/345 AceView cDNA sequences (see all 345): BC009516 BG746573 AI754515 CD676818 BM784575 BM709380 BM708373 BQ011879 AI056614 CD367383 AI493009 BX640702 BU858289 CD742719 AI560410 BG026786 CA446197 CR598967 AX747637 AA281437 BU679598 AI554557 BQ027452 CB117419
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CLN6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLN6
|
Expression
for CLN6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLN6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CLN6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLN6
SOURCE GeneReport for Unigene cluster: Hs.584921
SABiosciences Custom PCR Arrays for CLN6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLN6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLN6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLN6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLN6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLN6 |
Orthologs
for CLN6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLN6 gene from 5/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cln61 , 5 |
ceroid-lipofuscinosis, neuronal 61, 5 |
87.83(n)1
91.45(a)1 |
|
9 (33.89 cM)5
765241 NM_001033175.21 NP_001028347.11
628387855 |
chicken
(Gallus gallus) |
Aves |
CLN61 |
ceroid-lipofuscinosis, neuronal 6, late infantile, more |
76.53(n)
75.88(a) |
|
415558 XM_413928.3 XP_413928.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CLN66 |
-- |
83(a) |
1 ↔ 1 |
GL343467.1(750932-758131) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.69762 |
Transcribed sequence with weak similarity to protein more |
74.7(n) |
|
BX720867.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.149692 |
Transcribed sequence with moderate similarity to protein more |
75.72(n) |
|
CK238175.1 |
ENSEMBL Gene Tree for CLN6 (if available)
TreeFam Gene Tree for CLN6 (if available) |
Paralogs
for CLN6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CLN6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLN6 (68499330 - 68549549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLN6: --
Human Gene Mutation Database (HGMD): CLN6
Locus Specific Mutation Databases (LSDB): CLN6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLN6 |
|
Disorders
/ Diseases
for CLN6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLN6 for disorders About GeneDecksing
OMIM gene information: 606725
OMIM disorders: 601780
UniProtKB/Swiss-Prot: CLN6_HUMAN, Q9NWW5
Defects in CLN6 are the cause of neuronal ceroid lipofuscinosis type 6 (CLN6) [MIM:601780]. A form of neuronalceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseasescharacterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures,dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroidlipofuscinosis type 6 comprise mixed combinations of granular, curvilinear, and fingerprint profiles Defects in CLN6 are the cause of neuronal ceroid lipofuscinosis type 4A (CLN4A) [MIM:204300]. An adult-onsetneuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storagediseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically byseizures, dementia, visual loss, and/or cerebral atrophy. CLN4A has no visual involvement and is characterized byprogressive myoclonic epilepsy
14  diseases for CLN6: About MalaCardsneuronal ceroid-lipofuscinoses ceroid lipofuscinosis neuronal 6 ceroid lipofuscinosis ceroid-lipofuscinosis, neuronal-6, variant late infantile
batten disease neuronitis neuronal ceroid-lipofuscinosis lysosomal storage disease
neurodegenerative disease cerebral atrophy blindness cerebritis
dementia cholesterol
2 diseases from the University of Copenhagen DISEASES database for CLN6:Neuronal ceroid lipofuscinosis Visual epilepsy 5 Novoseek disease relationships for CLN6 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neuronal ceroid lipofuscinoses |
95.9 |
1 |
19431184 (1) |
| ceroid lipofuscinosis, neuronal, late infantile, variant |
95.7 |
4 |
12673792 (1), 19520283 (1), 15010453 (1), 10191123 (1) |
| lincl |
93.9 |
4 |
10191126 (1), 19431184 (1), 15265688 (1), 17564970 (1) |
| neurodegenerative diseases |
72.8 |
1 |
11791207 (1) |
| blindness |
28.1 |
2 |
11791207 (1), 15010453 (1) |
GeneTests: CLN6
Neuronal Ceroid-Lipofuscinoses
Genetic Association Database (GAD): CLN6
Human Genome Epidemiology (HuGE) Navigator: CLN6 (1 document)
Export disorders for CLN6 gene to outside databases
|
Publications
for CLN6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLN6 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with CLN6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The gene mutated in variant late-infantile neuronal ceroid lipofuscinosis (CLN6) and in nclf mutant mice encodes a novel predicted transmembrane protein. (PubMed id 11727201)1, 2, 3, 9 Wheeler R.B....Mole S.E. (2002)
- Spectrum of CLN6 mutations in variant late infantile neuronal ceroid lipofuscinosis. (PubMed id 12815591)1, 2, 4 Sharp J.D....Mole S.E. (2003)
- Novel mutations in the CLN6 gene causing a variant late infantile neuronal ceroid lipofuscinosis. (PubMed id 12673792)1, 2, 9 Teixeira C.A....Boustany R.-M.N. (2003)
- CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein. (PubMed id 15265688)1, 2, 9 Mole S.E....Cutler D.F. (2004)
- Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. (PubMed id 11791207)1, 2, 9 Gao H....MacDonald M.E. (2002)
- Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis. (PubMed id 19201763)1, 2, 9 Kousi M....Lehesjoki A.-E. (2009)
- Kufs disease, the major adult form of neuronal ceroid lipofuscinosis, caused by mutations in CLN6. (PubMed id 21549341)1, 2 Arsov T....Berkovic S.F. (2011)
- Protein product of CLN6 gene responsible for variant l ate-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. (PubMed id 19235893)1, 2 Benedict J.W....Pearce D.A. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for CLN6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLN6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLN6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLN6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLN6 | Pharmacogenomics, SNPs, Pathways | | NCL CLN6 | http://www.ucl.ac.uk/ncl/cln6.shtml | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CLN6 |
|
| | |
About This Section
| Patent Information for CLN6 gene:
Search GeneIP for patents involving CLN6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLN6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLN6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLN6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLN6 | | | OriGene Protein Over-expression Lysate for CLN6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLN6 | | OriGene 3'-UTR Clone for CLN6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLN6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLN6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLN6 | | OriGene Custom Protein Services for CLN6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLN6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLN6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLN6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLN6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLN6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLN6 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CLN6 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CLN6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLN6 |
|  |  |  |  | | | | ThermoFisher Antibodies for CLN6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLN6 |
| |  | |
|
|
|
