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CLMP Gene

protein-coding   GIFtS: 50
GCID: GC11M122943

CXADR-Like Membrane Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CXADR-Like Membrane Protein1 2     Adipocyte-Specific Adhesion Molecule1 2
Adipocyte Adhesion Molecule1 2 3     CAR-Like Membrane Protein2 3
Coxsackie- And Adenovirus Receptor-Like Membrane Protein1 2 3     CSBS2 5
ACAM2 3 5     CSBM2
ASAM2 3 5     

External Ids:    HGNC: 240391   Entrez Gene: 798272   Ensembl: ENSG000001662507   OMIM: 6116935   UniProtKB: Q9H6B43   

Export aliases for CLMP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLMP Gene:
The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the
Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role
in cell-cell adhesion (Raschperger et al., 2004 (PubMed 14573622)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CLMP Gene:
CLMP (CXADR-like membrane protein) is a protein-coding gene. Diseases associated with CLMP include intestinal pseudo-obstruction, and intestinal pseudoobstruction, neuronal. An important paralog of this gene is VSIG2.

UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4
Function: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development
of obesity. Is required for normal small intestine development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CLMP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLMP promoter sequence
   Search Chromatin IP Primers for CLMP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24

CLMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLMP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M122943:  view genomic region     (about GC identifiers)

Start:
122,943,020 bp from pter      End:
123,066,007 bp from pter
Size:
122,988 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 (See protein sequence)
Recommended Name: CXADR-like membrane protein precursor  
Size: 373 amino acids; 41281 Da
Developmental stage: At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the
central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the
dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as
in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development,
increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP
in the parenchyma of the lobules and cortex, respectively

Explore the universe of human proteins at neXtProt for CLMP: NX_Q9H6B4

Explore proteomics data for CLMP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn197
  • Modification sites at PhosphoSitePlus

  • See CLMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079045.1  
    ENSEMBL proteins: 
     ENSP00000405577  

    CLMP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CLMP (ASAM)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CLMP
    OriGene Protein Over-expression Lysate for CLMP
    OriGene MassSpec for CLMP
    OriGene Custom Protein Services for CLMP
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    Novus Biologicals CLMP Protein
    Novus Biologicals CLMP Lysate
    Sino Biological Recombinant Protein for CLMP
    Sino Biological Cell Lysate for CLMP
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLMP

    CLMP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CLMP (ASAM)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLMP
    Novus Biologicals CLMP Antibody
    Abcam antibodies for CLMP
    Cloud-Clone Corp. Antibodies for CLMP
    Search ThermoFisher Antibodies for CLMP
    LSBio Antibodies in human, mouse, rat for CLMP

    CLMP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CLMP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLMP
    Cloud-Clone Corp. CLIAs for CLMP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9H6B4

    ProtoNet protein and cluster: Q9H6B4

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    CLMP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLMP_HUMAN, Q9H6B4
    Function: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development
    of obesity. Is required for normal small intestine development
    Induction: Up-regulated in mature adipocytes and adipocyte tissue of obese individuals

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CLMP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CLMP:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Clmp (no phenotypes)

    CLMP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clmptm1Lex for CLMP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLMP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLMP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLMP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLMP

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLMP:
    hsa-mir-124-3p (MIRT022869)

    Block miRNA regulation of human, mouse, rat CLMP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLMP (see all 12):
    hsa-miR-644 hsa-miR-147 hsa-miR-4299 hsa-miR-3647-3p hsa-miR-29b-1* hsa-miR-4294 hsa-miR-4287 hsa-miR-153
    SwitchGear 3'UTR luciferase reporter plasmidCLMP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLMP
    Predesigned siRNA for gene silencing in human, mouse, rat CLMP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLMP

    Clone
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    OriGene clones in human, mouse for CLMP (see all 8)
    OriGene ORF clones in mouse, rat for CLMP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLMP (NM_024769)
    Sino Biological Human cDNA Clone for CLMP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLMP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLMP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CLMP
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLMP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLMP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLMP_HUMAN, Q9H6B4: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein
    (Potential)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CLMP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLMP
    Interactions:

        Search GeneGlobe Interaction Network for CLMP

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048565digestive tract development IMP--

    CLMP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLMP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLMP gene: 
    NM_024769.2  

    Unigene Cluster for CLMP:

    CXADR-like membrane protein
    Hs.591949  [show with all ESTs]
    Unigene Representative Sequence: NM_024769
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448775(uc001pyt.3) ENST00000530371 ENST00000527977 ENST00000529128

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLMP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLMP (see all 12):
    hsa-miR-644 hsa-miR-147 hsa-miR-4299 hsa-miR-3647-3p hsa-miR-29b-1* hsa-miR-4294 hsa-miR-4287 hsa-miR-153
    SwitchGear 3'UTR luciferase reporter plasmidCLMP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLMP
    Predesigned siRNA for gene silencing in human, mouse, rat CLMP
    Clone
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    OriGene clones in human, mouse for CLMP (see all 8)
    OriGene ORF clones in mouse, rat for CLMP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLMP (NM_024769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLMP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLMP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CLMP
    OriGene qSTAR qPCR primer pairs in human, mouse for CLMP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLMP
      QuantiTect SYBR Green Assays in human, mouse, rat CLMP
      QuantiFast Probe-based Assays in human, mouse, rat CLMP

    Additional mRNA sequence: 

    AK026068.1 AK304843.1 AY326422.1 AY358340.1 BC009371.2 

    3 DOTS entries:

    DT.40315370  DT.101980420  DT.91705159 

    Selected AceView cDNA sequences (see all 87):

    AA489480 BU621985 BK001245 CA429529 AA486079 BM728789 BX113005 AK026068 
    BM995089 BU742636 BX505994 AL134562 AI627496 CA420415 BG255343 BM728708 
    AW963657 BG170725 NM_024769 AL702438 AA909305 AA486137 BM679454 AI962508 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CLMP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                            
    SP2:                                      -                     


    ECgene alternative splicing isoforms for CLMP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLMP expression in normal human tissues (normalized intensities)      CLMP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAGGCA
    CLMP Expression
    About this image


    CLMP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             White adipocyte-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
    CLMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLMP Protein Expression

    Genevestigator expression for CLMP

    SOURCE GeneReport for Unigene cluster: Hs.591949

    UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4
    Tissue specificity: Predominantly expressed in epithelial cells within different tissues and in the white adipose
    tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal
    muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly
    abundant in the intestine during embryo and fetal development (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat CLMP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLMP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CLMP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clmp1 , 5 RIKEN cDNA 9030425E11 gene5
    CXADR-like membrane protein1
    87.82(n)1
    93.68(a)1
      9 (21.42 cM)5
    715661  NM_133733.41  NP_598494.21 
     406859625 
    chicken
    (Gallus gallus)
    Aves CLMP1 CXADR-like membrane protein 68.47(n)
    68.47(a)
      419747  XM_417886.3  XP_417886.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLMP6
    CXADR-like membrane protein
    61(a)
    1 ↔ 1
    LGa(3033612-3078474)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX739967.12   -- 75.29(n)    BX739967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003308771 CXADR-like membrane protein-like 55.48(n)
    49.48(a)
      100330877  XM_003200491.2  XP_003200539.2 


    ENSEMBL Gene Tree for CLMP (if available)
    TreeFam Gene Tree for CLMP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLMP gene
    VSIG22  CXADR2  C1orf2042  ESAM2  VSIG82  GPA332  IGSF112  VSIG12  
    1 SIMAP similar gene for CLMP using alignment to 1 protein entry:     CLMP_HUMAN:
    CXADR

    CLMP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLMP (see all 2884)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697134
    Congenital short bowel syndrome (CSBS)4--see VAR_0697132 V D mis40--------
    rs1886904311,2
    --118884206(+) GTATCA/GAGAGT 1 -- int10--------
    rs1413228551,2
    --118884276(+) CAAACA/GTCTTT 1 -- int10--------
    rs747469031,2
    C,F--118884519(+) GGGAAC/TGGTTA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs112189501,2
    C,F,H--118884580(+) TGATAG/ATTTAA 1 -- int118Minor allele frequency- A:0.19NS EA NA CSA WA 2333
    rs1503885321,2
    --118884718(+) GAGTCG/TTGCTT 1 -- ut310--------
    rs1380294421,2
    C--118884856(+) AATCTC/TCCTTT 1 -- ut310--------
    rs1425701461,2
    C--118884880(+) TCTTGC/GAATTC 1 -- ut310--------
    rs1463188861,2
    --118884894(+) TTTCAC/TATTTT 1 -- ut310--------
    rs1396370191,2
    --118884915(+) AGAGAC/GTATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLMP (122943020 - 123066007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLMP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745165CNV Deletion23290073
    esv2745163CNV Deletion23290073

    Human Gene Mutation Database (HGMD): CLMP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLMP
    DNA2.0 Custom Variant and Variant Library Synthesis for CLMP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611693   
    OMIM disorders: 615237  
    UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4
  • Congenital short bowel syndrome (CSBS) [MIM:615237]: A disease characterized by a shortened small
    intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is
    approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe
    malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require
    parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications
    such as sepsis and liver failure which are associated with a high rate of mortality early in life. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for CLMP:    About MalaCards
    intestinal pseudo-obstruction    intestinal pseudoobstruction, neuronal    short bowel syndrome    endotheliitis
    choroiditis    esophageal cancer    obesity    esophagitis


    CLMP for disorders           About GeneDecksing


    Export disorders for CLMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLMP gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CLMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. (PubMed id 14573622)1, 2, 3, 9 Raschperger E.... Fuxe J. (J. Biol. Chem. 2004)
    2. Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. (PubMed id 15563274)1, 2, 9 Eguchi J.... Makino H. (Biochem. J. 2005)
    3. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PubMed id 12851705)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    4. CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome. (PubMed id 22155368)1, 2 Van Der Werf C.S....Hofstra R.M. (Gastroenterology 2012)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development. (PubMed id 23460781)1 van der Werf C.S....van Ijzendoorn S.C. (PLoS ONE 2013)
    7. Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. (PubMed id 22992863)1 Ma J....Dong Z. (Int. J. Mol. Med. 2012)
    8. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the coxsackievirus and adenovirus receptor. (PubMed id 22718816)1 Kolawole A.O....Ashbourne Excoffon K.J. (J. Virol. 2012)
    9. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79827 HGNC: 24039 AceView: ASAM Ensembl:ENSG00000166250 euGenes: HUgn79827
    ECgene: CLMP H-InvDB: CLMP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLMP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CLMP gene:
    Search GeneIP for patents involving CLMP

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