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Aliases for CLMP Gene

Aliases for CLMP Gene

  • CXADR-Like Membrane Protein 2 3 5
  • Coxsackie- And Adenovirus Receptor-Like Membrane Protein 2 3 4
  • Adipocyte-Specific Adhesion Molecule 2 3
  • Adipocyte Adhesion Molecule 2 4
  • CAR-Like Membrane Protein 3 4
  • ACAM 3 4
  • ASAM 3 4
  • CSBM 3
  • CSBS 3

External Ids for CLMP Gene

Previous GeneCards Identifiers for CLMP Gene

  • GC11M122943

Summaries for CLMP Gene

Entrez Gene Summary for CLMP Gene

  • This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

GeneCards Summary for CLMP Gene

CLMP (CXADR-Like Membrane Protein) is a Protein Coding gene. Diseases associated with CLMP include congenital short bowel syndrome and short bowel syndrome. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot for CLMP Gene

  • May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLMP Gene

Genomics for CLMP Gene

Regulatory Elements for CLMP Gene

Promoters for CLMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLMP on UCSC Golden Path with GeneCards custom track

Genomic Location for CLMP Gene

Chromosome:
11
Start:
123,069,865 bp from pter
End:
123,195,299 bp from pter
Size:
125,435 bases
Orientation:
Minus strand

Genomic View for CLMP Gene

Genes around CLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLMP Gene

Proteins for CLMP Gene

  • Protein details for CLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6B4-CLMP_HUMAN
    Recommended name:
    CXADR-like membrane protein
    Protein Accession:
    Q9H6B4

    Protein attributes for CLMP Gene

    Size:
    373 amino acids
    Molecular mass:
    41281 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLMP Gene

Proteomics data for CLMP Gene at MOPED

Post-translational modifications for CLMP Gene

  • Glycosylation at Asn 74 and Asn 197
  • Modification sites at PhosphoSitePlus

Other Protein References for CLMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLMP Gene

Domains & Families for CLMP Gene

Protein Domains for CLMP Gene

Suggested Antigen Peptide Sequences for CLMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6B4

UniProtKB/Swiss-Prot:

CLMP_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CLMP: view

Function for CLMP Gene

Molecular function for CLMP Gene

UniProtKB/Swiss-Prot Function:
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.
UniProtKB/Swiss-Prot Induction:
Up-regulated in mature adipocytes and adipocyte tissue of obese individuals.
genes like me logo Genes that share phenotypes with CLMP: view

Human Phenotype Ontology for CLMP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CLMP Gene

Localization for CLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLMP Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLMP Gene COMPARTMENTS Subcellular localization image for CLMP gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IDA 22155368
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CLMP: view

Pathways & Interactions for CLMP Gene

SuperPathways for CLMP Gene

No Data Available

Interacting Proteins for CLMP Gene

Gene Ontology (GO) - Biological Process for CLMP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLMP Gene

Drugs & Compounds for CLMP Gene

No Compound Related Data Available

Transcripts for CLMP Gene

Unigene Clusters for CLMP Gene

CXADR-like membrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLMP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for CLMP Gene

GeneLoc Exon Structure for
CLMP
ECgene alternative splicing isoforms for
CLMP

Expression for CLMP Gene

mRNA expression in normal human tissues for CLMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLMP Gene

This gene is overexpressed in Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for CLMP Gene

This gene is overexpressed in Urine (32.0), Gallbladder (12.8), Adipocyte (10.4), and Fetal Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CLMP Gene



SOURCE GeneReport for Unigene cluster for CLMP Gene Hs.591949

mRNA Expression by UniProt/SwissProt for CLMP Gene

Q9H6B4-CLMP_HUMAN
Tissue specificity: Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).
genes like me logo Genes that share expression patterns with CLMP: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CLMP Gene

Orthologs for CLMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLMP 35
  • 89.19 (n)
  • 90.08 (a)
ASAM 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLMP 35
  • 93.13 (n)
  • 94.77 (a)
CLMP 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clmp 35
  • 87.82 (n)
  • 93.68 (a)
Clmp 16
Clmp 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLMP 35
  • 100 (n)
  • 100 (a)
CLMP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clmp 35
  • 87.73 (n)
  • 93.96 (a)
oppossum
(Monodelphis domestica)
Mammalia CLMP 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLMP 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLMP 35
  • 68.47 (n)
  • 68.47 (a)
CLMP 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLMP 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clmp 35
  • 59.22 (n)
  • 52.75 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330877 35
  • 55.48 (n)
  • 49.48 (a)
CLMP 36
  • 44 (a)
OneToOne
Species with no ortholog for CLMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLMP Gene

ENSEMBL:
Gene Tree for CLMP (if available)
TreeFam:
Gene Tree for CLMP (if available)

Paralogs for CLMP Gene

(1) SIMAP similar genes for CLMP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLMP: view

Variants for CLMP Gene

Sequence variations from dbSNP and Humsavar for CLMP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_049824 -
VAR_069713 Congenital short bowel syndrome (CSBS)
rs485112 -- 123,126,814(+) atggc(A/C)cgaac intron-variant
rs476911 -- 123,168,928(+) TCCAA(A/C/G)CATTC intron-variant
rs477232 -- 123,092,941(+) ctcat(G/T)ctgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLMP Gene

Variant ID Type Subtype PubMed ID
esv2745163 CNV Deletion 23290073
esv2745165 CNV Deletion 23290073

Variation tolerance for CLMP Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 54.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLMP Gene

HapMap Linkage Disequilibrium report
CLMP
Human Gene Mutation Database (HGMD)
CLMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLMP Gene

Disorders for CLMP Gene

MalaCards: The human disease database

(8) MalaCards diseases for CLMP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital short bowel syndrome
  • congenital short bowel and malrotation syndrome
short bowel syndrome
  • acquired short bowel syndrome
intestinal volvulus
  • twist of intestine, bowel, or colon
coronary aneurysm
  • aneurysm of coronary vessels
heart aneurysm
  • cardiac aneurysm
- elite association - COSMIC cancer census association via MalaCards
Search CLMP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CLMP_HUMAN
  • Congenital short bowel syndrome (CSBS) [MIM:615237]: A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life. {ECO:0000269 PubMed:22155368}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CLMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLMP
genes like me logo Genes that share disorders with CLMP: view

No data available for Genatlas for CLMP Gene

Publications for CLMP Gene

  1. CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. (PMID: 14573622) Raschperger E. … Fuxe J. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PMID: 12851705) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  3. Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. (PMID: 15563274) Eguchi J. … Makino H. (Biochem. J. 2005) 3 23
  4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. (PMID: 23264731) Fong K.W. … Chen J. (J. Cell Sci. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for CLMP Gene

Sources for CLMP Gene

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