CLMP Gene
protein-coding GIFtS : 47
GCID: GC11 M122943
CXADR-like membrane protein
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Aliasesfor CLMP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases CXADR-Like Membrane Protein 1 2 Coxsackie- And Adenovirus Receptor-Like Membrane Protein2 3 ACAM1 2 3 5 CAR-Like Membrane Protein2 3 ASAM1 2 3 5 FLJ224151 Adipocyte Adhesion Molecule2 3 Adipocyte-Specific Adhesion Molecule2
Export aliases for CLMP gene to outside databases
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Summariesfor CLMP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CLMP : The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al., 2004 (PubMed 14573622)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 Function : May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development ofobesity
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Genomic Viewsfor CLMP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CLMP Other transcription factors Search SABiosciences Chromatin IP Primers for CLMP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLMP
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24 CLMP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M122943: view genomic region
(about GC identifiers )
Start:
122,943,020 bp from pter
End:
123,066,007 bp from pter
Size:
122,988 bases
Orientation:
minus strand
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Proteinsfor CLMP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 (See
protein sequence )Recommended Name: CXADR-like membrane protein precursor Size : 373 amino acids; 41281 Da
Subcellular location : Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein (Potential)Explore the universe of human proteins at neXtProt for CLMP: NX_Q9H6B4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H6B4 CLMP Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_079045.1 ENSEMBL proteins: ENSP00000405577 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
CLMP for ontologies About GeneDecksing CLMP Antibody Products: Assay Products for CLMP:
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Protein
Domains / Familiesfor CLMP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CLMP for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H6B4 ProtoNet protein and cluster: Q9H6B4
2 Blocks protein families : IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 Similarity : Contains 2 Ig-like C2-type (immunoglobulin-like) domains
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Functionfor CLMP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 Function : May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development ofobesity Induction : Up-regulated in mature adipocytes and adipocyte tissue of obese individuals
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLMP (NM_024769 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLMP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLMP
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLMP
1 GenomeRNAi human phenotype for CLMP :Animal Models: Mouse knock-out Clmp tm1Lex for CLMP 1 MGI phenotypic allele for Clmp (no phenotypes)
CLMP for phenotypes About GeneDecksing
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Pathways & Interactionsfor CLMP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLMP
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Drugs & Compoundsfor CLMP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CLMP Search CenterWatch for drugs/clinical trials and news about CLMP
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Transcriptsfor CLMP gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CLMP gene: NM_024769.2 Unigene Cluster for CLMP:
CXADR-like membrane protein Hs.591949 [show with all ESTs ] Unigene Representative Sequence: NM_024769 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000448775 (uc001pyt.3 ) ENST00000530371 ENST00000527977 ENST00000529128 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLMP (NM_024769 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLMP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLMP
Additional cDNA sequence: AK026068.1 AK304843.1 AY326422.1 AY358340.1 BC009371.2
3 DOTS entries : DT.40315370 DT.101980420
DT.91705159 24/87 AceView cDNA sequences (see all 87 ):
AI656765 BG170725 BM995089 BU631171 BQ010255 AA909305 BX113005 BX505994 BU621985 CR622259 AI627496 BM728789 AK026068 AI962508 BU742636 BG255343 CB129158 AA486137 AA486079 AL702438 BM728708 BX090712 CB123619 AA489480 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for CLMP About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b SP1 :                     SP2 :             -        
ECgene alternative splicing isoforms for CLMP
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Expression for CLMP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CLMP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGCCAGGCA
About this image CLMP expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Genevestigator expression for CLMP SOURCE GeneReport for Unigene cluster: Hs.591949 UniProtKB/Swiss-Prot: CLMP_HUMAN, Q9H6B4 Tissue specificity : Predominantly expressed in epithelial cells within different tissues and in the white adiposetissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes SABiosciences Custom PCR Arrays for CLMP Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLMPBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CLMP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLMP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLMP In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLMP
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Orthologsfor CLMP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CLMP gene from 4/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CLMP1
CXADR-like membrane protein
67.83(n) 66.85(a)
 
419747 XM_417886.2 XP_417886.3
lizard (Anolis carolinensis)
Reptilia
CLMP6
--
65(a)
1 ↔ 1
LGa(3035153-3039982)
tropical clawed frog (Xenopus tropicalis)
Amphibia
BX739967.12
--
75.29(n)
 
BX739967.1
zebrafish (Danio rerio)
Actinopterygii
LOC5671791
adipocyte adhesion molecule-like
58.14(n) 51.99(a)
 
567179 XM_690472.3 XP_695564.3
ENSEMBL Gene Tree for CLMP (if available)TreeFam Gene Tree for CLMP (if available)
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Paralogsfor CLMP gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CLMP gene ESAM 2 VSIG8 2 GPA33 2 JAM2 2 VSIG1 2 CXADR 2 VSIG2 2 C1orf204 2 IGSF11 2 JAM3 2 F11R 2 1 SIMAP similar gene for CLMP using alignment to 1 protein entry: CLMP_HUMAN :CXADR
CLMP for paralogs About GeneDecksing
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Genomic Variantsfor CLMP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CLMP (122943020 - 123066007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CLMP: -- Human Gene Mutation Database (HGMD) : CLMP SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLMP
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Disorders
/ Diseasesfor CLMP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CLMP for disorders About GeneDecksing
OMIM gene information: 611693
OMIM disorders : --3 diseases for CLMP : About MalaCards choroiditis gastric cancer obesity Export disorders for CLMP gene to outside databases
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Publicationsfor CLMP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CLMP gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with CLMP) Utopia : connect your pdf to the dynamic world of online information
CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. (PubMed id 14573622) 1 , 2 , 3, 9 Raschperger E.... Fuxe J. (2004) Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. (PubMed id 15563274) 1 , 2 , 9 Eguchi J.... Makino H. (2005) IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PubMed id 12851705) 1 , 3, 9 Katoh M. and Katoh M. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) CLMP is required for intestinal development, and loss- of-function mutations cause congenital short-bowel syndrome. (PubMed id 22155368) 1 Van Der Werf C.S....Hofstra R.M. (2012) The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight -exon isoform of the coxsackievirus and adenovirus receptor. (PubMed id 22718816) 1 Kolawole A.O....Ashbourne Excoffon K.J. (2012) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. (PubMed id 17538635) 1 Kawabata K....Mizuguchi H. (2007)
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External Searches for CLMP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CLMP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CLMP gene
(According to HUGE )
About This Section --
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Specialized Databases showing CLMP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CLMP gene: Search GeneIP for patents involving CLMP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CLMP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CLMP OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CLMP OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLMP OriGene Protein Over-expression Lysate for CLMP Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CLMP OriGene 3'-UTR Clone for CLMP OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLMP Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CLMP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CLMP OriGene Custom Protein Services for CLMP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLMP QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLMP QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLMP QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CLMP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLMP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLMP
Search Tocris compounds for CLMP
CLMP Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLMP
Search ThermoFisher Antibodies for CLMP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLMP
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Aliases for CLMP
Databases for CLMP
Disorders / Diseases for CLMP
Domains / Families for CLMP
Drugs / Compounds for CLMP
Expression for CLMP
Function for CLMP
Genomic Views for CLMP
Intellectual Property for CLMP
Orthologs for CLMP
Paralogs for CLMP
Pathways / Interactions for CLMP
Products for CLMP
Proteins for CLMP
Publications for CLMP
Search Box for CLMP
Summaries for CLMP
Transcripts for CLMP
Variants for CLMP
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