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Aliases for CLMN Gene

Aliases for CLMN Gene

  • Calmin (Calponin-Like, Transmembrane) 2 3 5
  • Calponin-Like Transmembrane Domain Protein 4
  • KIAA1188 4

External Ids for CLMN Gene

Previous GeneCards Identifiers for CLMN Gene

  • GC14M093167
  • GC14M089474
  • GC14M093644
  • GC14M093647
  • GC14M094727
  • GC14M095648
  • GC14M075832

Summaries for CLMN Gene

GeneCards Summary for CLMN Gene

CLMN (Calmin (Calponin-Like, Transmembrane)) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is SYNE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLMN Gene

Genomics for CLMN Gene

Regulatory Elements for CLMN Gene

Promoters for CLMN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLMN on UCSC Golden Path with GeneCards custom track

Genomic Location for CLMN Gene

Chromosome:
14
Start:
95,181,939 bp from pter
End:
95,319,908 bp from pter
Size:
137,970 bases
Orientation:
Minus strand

Genomic View for CLMN Gene

Genes around CLMN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLMN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLMN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLMN Gene

Proteins for CLMN Gene

  • Protein details for CLMN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JQ2-CLMN_HUMAN
    Recommended name:
    Calmin
    Protein Accession:
    Q96JQ2
    Secondary Accessions:
    • B2RAR7
    • Q9H713
    • Q9HA23
    • Q9HA57
    • Q9UFP4
    • Q9ULN2

    Protein attributes for CLMN Gene

    Size:
    1002 amino acids
    Molecular mass:
    111651 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13999.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14036.1; Type=Frameshift; Positions=493; Evidence={ECO:0000305}; Sequence=BAB14036.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

neXtProt entry for CLMN Gene

Proteomics data for CLMN Gene at MOPED

Post-translational modifications for CLMN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLMN Gene

No data available for DME Specific Peptides for CLMN Gene

Domains & Families for CLMN Gene

Protein Domains for CLMN Gene

Graphical View of Domain Structure for InterPro Entry

Q96JQ2

UniProtKB/Swiss-Prot:

CLMN_HUMAN :
  • Contains 1 actin-binding domain.
Domain:
  • Contains 1 actin-binding domain.
  • Contains 2 CH (calponin-homology) domains.
genes like me logo Genes that share domains with CLMN: view

No data available for Gene Families for CLMN Gene

Function for CLMN Gene

Gene Ontology (GO) - Molecular Function for CLMN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CLMN: view
genes like me logo Genes that share phenotypes with CLMN: view

Animal Models for CLMN Gene

MGI Knock Outs for CLMN:
  • Clmn tm1b(EUCOMM)Wtsi

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLMN Gene

Localization for CLMN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLMN Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLMN Gene COMPARTMENTS Subcellular localization image for CLMN gene
Compartment Confidence
cytosol 4
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for CLMN Gene

Pathways & Interactions for CLMN Gene

SuperPathways for CLMN Gene

No Data Available

Interacting Proteins for CLMN Gene

Gene Ontology (GO) - Biological Process for CLMN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLMN Gene

Drugs & Compounds for CLMN Gene

No Compound Related Data Available

Transcripts for CLMN Gene

Unigene Clusters for CLMN Gene

Calmin (calponin-like, transmembrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLMN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for CLMN Gene

GeneLoc Exon Structure for
CLMN
ECgene alternative splicing isoforms for
CLMN

Expression for CLMN Gene

mRNA expression in normal human tissues for CLMN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CLMN Gene

This gene is overexpressed in Islet of Langerhans (17.1), Urine (16.8), and Lung (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLMN Gene



SOURCE GeneReport for Unigene cluster for CLMN Gene Hs.301478

mRNA Expression by UniProt/SwissProt for CLMN Gene

Q96JQ2-CLMN_HUMAN
Tissue specificity: Widely expressed at intermediate level.
genes like me logo Genes that share expression patterns with CLMN: view

Protein tissue co-expression partners for CLMN Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CLMN Gene

Orthologs for CLMN Gene

This gene was present in the common ancestor of animals.

Orthologs for CLMN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLMN 35
  • 81.83 (n)
  • 77.11 (a)
CLMN 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLMN 35
  • 81.67 (n)
  • 75.28 (a)
CLMN 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clmn 35
  • 76.84 (n)
  • 72.57 (a)
Clmn 16
Clmn 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLMN 35
  • 99.39 (n)
  • 99.25 (a)
CLMN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clmn 35
  • 76.5 (n)
  • 70.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CLMN 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLMN 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLMN 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLMN 36
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CLMN 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kst 36
  • 4 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M116.5 36
  • 15 (a)
OneToOne
Species with no ortholog for CLMN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLMN Gene

ENSEMBL:
Gene Tree for CLMN (if available)
TreeFam:
Gene Tree for CLMN (if available)

Paralogs for CLMN Gene

genes like me logo Genes that share paralogs with CLMN: view

Variants for CLMN Gene

Sequence variations from dbSNP and Humsavar for CLMN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10149705 - 95,191,685(+) TCTGC(A/G)GGCTG nc-transcript-variant, reference, missense
rs717902 -- 95,215,025(-) TTTGC(C/T)GCACC intron-variant
rs721403 -- 95,225,879(-) GGAAC(C/G)AAACA intron-variant
rs1054195 -- 95,182,320(+) ACATT(A/C)AATCT nc-transcript-variant, utr-variant-3-prime
rs1054196 -- 95,182,087(-) ATTTG(A/C)ATAAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLMN Gene

Variant ID Type Subtype PubMed ID
nsv902209 CNV Gain 21882294
nsv528121 CNV Loss 19592680
nsv1412 CNV Insertion 18451855
esv2250778 CNV Deletion 18987734
esv270427 CNV Insertion 20981092
dgv89e55 CNV Gain 17911159
esv2749047 CNV Deletion 23290073
dgv384n67 CNV Gain 20364138

Variation tolerance for CLMN Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLMN Gene

HapMap Linkage Disequilibrium report
CLMN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLMN Gene

Disorders for CLMN Gene

Relevant External Links for CLMN

Genetic Association Database (GAD)
CLMN
Human Genome Epidemiology (HuGE) Navigator
CLMN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLMN

No disorders were found for CLMN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLMN Gene

Publications for CLMN Gene

  1. Calmin, a protein with calponin homology and transmembrane domains expressed in maturing spermatogenic cells. (PMID: 11386753) Ishisaki Z. … Huh N.-H. (Genomics 2001) 2 3 4 23 67
  2. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  3. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3
  4. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3
  5. Genetic variants associated with breast size also influence breast cancer risk. (PMID: 22747683) Eriksson N. … Tung J.Y. (BMC Med. Genet. 2012) 3

Products for CLMN Gene

Sources for CLMN Gene

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