CLLU1 Gene
protein-coding GIFtS: 36
GCID: GC12P092817
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chronic lymphocytic leukemia up-regulated 1
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Aliases
for CLLU1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Chronic Lymphocytic Leukemia Up-Regulated 11 2 | | Chronic Lymphocytic Leukemia Up-Regulated Protein 12 |
| External Ids: | HGNC: 298411 | Entrez Gene: 5740282 | Ensembl: ENSG000002571277 | UniProtKB: Q5K1313 | | ORGUL members: | |
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| NONCODE:n381903 n381904 n381906 | |
Export aliases for CLLU1 gene to outside databasesPrevious GC identifers: GC12U900504 GC12P091341 GC12P089882
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Summaries
for CLLU1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CLLU1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLLU1 gene promoter:
STAT1 Sox5 AML1a STAT4 STAT1beta Nkx2-5 POU3F2 STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLLU1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLLU1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22CLLU1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P092817: view genomic region
(about GC identifiers)
Start:
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92,815,307 bp from pter |
End:
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92,824,778 bp from pter |
Size:
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9,472 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for CLLU1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLLU1_HUMAN, Q5K131 (See
protein sequence)Recommended Name: Chronic lymphocytic leukemia up-regulated protein 1 Size: 121 amino acids; 14228 Da
Subcellular location: Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells
Miscellaneous: Tridimensional modeling predicts that it may interact with the IL-4 receptor
Miscellaneous: This protein has no orthologs in other species and appears to be the product of a protein-coding genewhich has arisen since divergence from chimpExplore the universe of human proteins at neXtProt for CLLU1: NX_Q5K131
CLLU1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020404.1
ENSEMBL proteins: ENSP00000367746
Human Recombinant Protein Products for CLLU1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CLLU1 for ontologies About GeneDecksing
CLLU1 Antibody Products:
Assay Products for CLLU1: |
Protein
Domains /
Families
for CLLU1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5K131 |
Function
for CLLU1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLLU1 (NM_001025232) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLLU1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLLU1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLLU1 |
|
Pathways & Interactions
for CLLU1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLLU1
|
Drugs & Compounds
for CLLU1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLLU1
Search CenterWatch for drugs/clinical trials and news about CLLU1
|
Transcripts
for CLLU1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLLU1 gene: NM_001025233.1 Unigene Cluster for CLLU1: Chronic lymphocytic leukemia up-regulated 1 Hs.730377 [show with all ESTs]Unigene Representative Sequence: AJ8451655 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589406 ENST00000472839(uc001tcc.2) ENST00000512817(uc001tcd.2)
ENST00000586526 ENST00000378485(uc001tcf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLLU1 (NM_001025232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLLU1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLLU1 |
Additional cDNA sequence: AJ845162.1 AJ845163.1 AJ845164.1 AJ845165.1 AJ845167.1 BC014496.1 NR_027932.1 NR_027933.1 2 DOTS entries: DT.101979892 DT.121204684
GeneLoc Exon Structure
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Expression
for CLLU1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLLU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTGTAAAA
About this image
See CLLU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLLU1
SOURCE GeneReport for Unigene cluster: Hs.730377
UniProtKB/Swiss-Prot: CLLU1_HUMAN, Q5K131Tissue specificity: Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients withoutimmunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patientsbefore and after treatment
SABiosciences Custom PCR Arrays for CLLU1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLLU1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CLLU1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLLU1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLLU1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLLU1 |
Orthologs
for CLLU1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for CLLU1 (if available)
TreeFam Gene Tree for CLLU1 (if available) |
Paralogs
for CLLU1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CLLU1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLLU1 (92815307 - 92824778 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CLLU1
5 CNVs: 86516 86517 86515 86518 86514 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CLLU1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLLU1 for disorders About GeneDecksing
3  diseases for CLLU1: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia
1 disease from the University of Copenhagen DISEASES database for CLLU1:Chronic lymphocytic leukemia Export disorders for CLLU1 gene to outside databases
|
Publications
for CLLU1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLLU1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLLU1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recent de novo origin of human protein-coding genes. (PubMed id 19726446)1, 2, 3 Knowles D.G. and McLysaght A. (2009)
- The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone. (PubMed id 19212335)1, 2 Buhl A.M.... Leffers H. (2009)
- CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia. (PubMed id 17284524)1, 2 Josefsson P.... Buhl A.M. (2007)
- Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. (PubMed id 16339396)1, 2 Buhl A.M.... Leffers H. (2006)
- CLLU1 expression distinguishes chronic lymphocytic leu kemia from other mature B-cell neoplasms. (PubMed id 22738889)1 Oppliger Leibundgut E....Baerlocher G.M. (2012)
- Analysis of CLLU1 expression levels before and after therapy in patients with chronic lymphocytic leukemia. (PubMed id 21323738)1 Buhl A.M....Kipps T.J. (2011)
- [Expression of CLLU1 in patients with chronic lymphocytic leukemia and its prognostic significance] (PubMed id 18457263)1 Chen L.J....Li J.Y. (2007)
- The prognostic evaluation of CLLU1 expression levels in 50 Chinese patients with chronic lymphocytic leukemia. (PubMed id 17786715)1 Chen L....Xu W. (2007)
- CLLU1 expression levels predict time to initiation of therapy and overall survival in chronic lymphocytic leukemia. (PubMed id 16529606)1 Buhl A.M....Leffers H. (2006)
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External Searches for CLLU1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CLLU1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLLU1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLLU1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CLLU1 gene:
Search GeneIP for patents involving CLLU1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLLU1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLLU1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLLU1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLLU1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLLU1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLLU1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLLU1 | | OriGene Custom Protein Services for CLLU1 | | | OriGene Custom Immunoassay Development | | |
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 |  |  |  | |
| | | | Search Tocris compounds for CLLU1 |
| |  |  |  |  | | | | |
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 | | | CLLU1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLLU1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CLLU1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLLU1 |
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