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Aliases for CLLU1 Gene

Aliases for CLLU1 Gene

  • Chronic Lymphocytic Leukemia Up-Regulated 1 2 3

External Ids for CLLU1 Gene

Previous GeneCards Identifiers for CLLU1 Gene

  • GC12U900504
  • GC12P091341
  • GC12P092817
  • GC12P089882

Summaries for CLLU1 Gene

Entrez Gene Summary for CLLU1 Gene

  • The protein encoded by this gene is overexpressed in chronic lymphocytic leukemia (CLL) and serves as a good prognostic marker for the disease. Methylation of certain genes, including this one, have been associated with CLL. This gene is protein-coding in humans and non-protein coding in other primates. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CLLU1 Gene

CLLU1 (Chronic Lymphocytic Leukemia Up-Regulated 1) is a Protein Coding gene. Diseases associated with CLLU1 include chronic lymphocytic leukemia and leukemia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLLU1 Gene

Genomics for CLLU1 Gene

Regulatory Elements for CLLU1 Gene

Genomic Location for CLLU1 Gene

92,421,531 bp from pter
92,431,002 bp from pter
9,472 bases
Plus strand

Genomic View for CLLU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLLU1 Gene

Proteins for CLLU1 Gene

  • Protein details for CLLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chronic lymphocytic leukemia up-regulated protein 1
    Protein Accession:

    Protein attributes for CLLU1 Gene

    121 amino acids
    Molecular mass:
    14228 Da
    Quaternary structure:
    No Data Available
    • This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp
    • Tridimensional modeling predicts that it may interact with the IL-4 receptor

neXtProt entry for CLLU1 Gene

Proteomics data for CLLU1 Gene at MOPED

Post-translational modifications for CLLU1 Gene

No Post-translational modifications

Other Protein References for CLLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLLU1 Gene

Domains & Families for CLLU1 Gene

Protein Domains for CLLU1 Gene


Suggested Antigen Peptide Sequences for CLLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLLU1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CLLU1 Gene

Function for CLLU1 Gene

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLLU1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLLU1 Gene

Localization for CLLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLLU1 Gene

Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.

Gene Ontology (GO) - Cellular Components for CLLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLLU1: view

No data available for Subcellular locations from COMPARTMENTS for CLLU1 Gene

Pathways & Interactions for CLLU1 Gene

SuperPathways for CLLU1 Gene

No Data Available

Interacting Proteins for CLLU1 Gene

Gene Ontology (GO) - Biological Process for CLLU1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLLU1 Gene

Drugs & Compounds for CLLU1 Gene

No Compound Related Data Available

Transcripts for CLLU1 Gene

mRNA/cDNA for CLLU1 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLLU1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLLU1 Gene

No ASD Table

Relevant External Links for CLLU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLLU1 Gene

mRNA expression in normal human tissues for CLLU1 Gene

mRNA differential expression in normal tissues according to GTEx for CLLU1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

SOURCE GeneReport for Unigene cluster for CLLU1 Gene Hs.730377

mRNA Expression by UniProt/SwissProt for CLLU1 Gene

Tissue specificity: Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patients before and after treatment.
genes like me logo Genes that share expression patterns with CLLU1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLLU1 Gene

Orthologs for CLLU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLLU1 35
  • 98.07 (n)
  • 98.35 (a)
Species with no ortholog for CLLU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLLU1 Gene

Gene Tree for CLLU1 (if available)
Gene Tree for CLLU1 (if available)

Paralogs for CLLU1 Gene

No data available for Paralogs for CLLU1 Gene

Variants for CLLU1 Gene

Sequence variations from dbSNP and Humsavar for CLLU1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6538329 -- 92,430,817(+) actct(G/T)gttgt utr-variant-3-prime, nc-transcript-variant
rs7308198 -- 92,430,922(+) ataaa(A/C)tgagc utr-variant-3-prime, nc-transcript-variant
rs12300966 -- 92,431,496(+) atttt(A/T)aaaaa downstream-variant-500B
rs17251627 -- 92,430,628(+) CTGTG(A/G)CTTGC utr-variant-3-prime, nc-transcript-variant
rs59243836 -- 92,430,774(+) CCATA(G/T)ACTCC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CLLU1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855

Variation tolerance for CLLU1 Gene

Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLLU1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLLU1 Gene

Disorders for CLLU1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLLU1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
- elite association
Search CLLU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLLU1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLLU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLLU1 Gene

Publications for CLLU1 Gene

  1. Recent de novo origin of human protein-coding genes. (PMID: 19726446) Knowles D.G. … McLysaght A. (Genome Res. 2009) 2 67
  2. CLLU1 expression has prognostic value in chronic lymphocytic leukemia after first-line therapy in younger patients and in those with mutated IGHV genes. (PMID: 22899580) Gonzalez D. … Catovsky D. (Haematologica 2013) 67
  3. CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms. (PMID: 22738889) Oppliger Leibundgut E. … Baerlocher G.M. (Leuk. Res. 2012) 67
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 67
  5. Analysis of CLLU1 expression levels before and after therapy in patients with chronic lymphocytic leukemia. (PMID: 21323738) Buhl A.M. … Kipps T.J. (Eur. J. Haematol. 2011) 67

Products for CLLU1 Gene

Sources for CLLU1 Gene

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