Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLLU1 Gene

Subcategory (RNA class) for CLLU1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CLLU1 Gene

  • Chronic Lymphocytic Leukemia Up-Regulated 1 2 3 5

External Ids for CLLU1 Gene

Previous GeneCards Identifiers for CLLU1 Gene

  • GC12U900504
  • GC12P091341
  • GC12P092817
  • GC12P089882

Summaries for CLLU1 Gene

Entrez Gene Summary for CLLU1 Gene

  • Expression of this gene has been shown to be upregulated in some individuals with chronic lymphocytic leukemia (CLL), and has been used for prognostic and diagnostic purposes. This gene was originally identified as a human-specific putative protein-coding gene due to the presence of a peptide (PAp00140670, HIIYSTFLSK) that could have supported translation at this locus. This peptide is not present in more recent builds of PeptideAtlas, and the presence of a protein product at this locus has not been independently verified. For this reason, this gene is being represented as non-coding. Sequence comparisons to other primates indicates that no other primate is predicted to contain an open reading frame. [provided by RefSeq, Feb 2017]

GeneCards Summary for CLLU1 Gene

CLLU1 (Chronic Lymphocytic Leukemia Up-Regulated 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CLLU1 include Chronic Lymphocytic Leukemia and Leukemia.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLLU1 Gene

Genomics for CLLU1 Gene

Regulatory Elements for CLLU1 Gene

Enhancers for CLLU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G092442 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +24.0 23974 5.8 TBP PKNOX1 WRNIP1 CBX5 ZNF143 RELB ETV6 IKZF2 CREM SMAD5 CLLU1 LINC02397 C12orf74 BTG1 ENSG00000257252 EEA1 CLLU1OS
GH12G092028 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -388.6 -388581 8.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 BTG1 LOC101928617 CLLU1 GC12P092067 LOC105369901
GH12G092459 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +45.4 45373 13.8 HDGF PKNOX1 WRNIP1 FEZF1 YY1 TCF12 GATA2 ZNF143 ZNF207 JUNB CLLU1OS LINC02397 C12orf74 CLLU1 BTG1 LOC105369904
GH12G092501 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +83.1 83093 5.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YY1 ZNF207 FOS NFYC BTG1 CLLU1 EEA1 LOC105369904 LINC02397
GH12G092537 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +121.6 121623 11.6 HDGF PKNOX1 ATF1 YBX1 YY1 GATA2 CBX5 ZNF207 FOS ZHX2 LINC02397 CLLU1OS BTG1 CLLU1 EEA1 LOC100132126 LOC105369905
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLLU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLLU1 Gene

Chromosome:
12
Start:
92,421,531 bp from pter
End:
92,431,002 bp from pter
Size:
9,472 bases
Orientation:
Plus strand

Genomic View for CLLU1 Gene

Genes around CLLU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLLU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLLU1 Gene

Proteins for CLLU1 Gene

  • Protein details for CLLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K131-CLLU1_HUMAN
    Recommended name:
    Chronic lymphocytic leukemia up-regulated protein 1
    Protein Accession:
    Q5K131

    Protein attributes for CLLU1 Gene

    Size:
    121 amino acids
    Molecular mass:
    14228 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp.
    • Tridimensional modeling predicts that it may interact with the IL-4 receptor.

neXtProt entry for CLLU1 Gene

Post-translational modifications for CLLU1 Gene

No Post-translational modifications

Other Protein References for CLLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLLU1 Gene

Domains & Families for CLLU1 Gene

Protein Domains for CLLU1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CLLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLLU1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CLLU1 Gene

Function for CLLU1 Gene

Phenotypes for CLLU1 Gene

GenomeRNAi human phenotypes for CLLU1:
genes like me logo Genes that share phenotypes with CLLU1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLLU1 Gene

Localization for CLLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLLU1 Gene

Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.

Gene Ontology (GO) - Cellular Components for CLLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLLU1: view

No data available for Subcellular locations from COMPARTMENTS for CLLU1 Gene

Pathways & Interactions for CLLU1 Gene

SuperPathways for CLLU1 Gene

No Data Available

Interacting Proteins for CLLU1 Gene

Selected Interacting proteins: Q5K131-CLLU1_HUMAN for CLLU1 Gene via IID

Symbol External ID(s) Details
CD38
ZAP70

Gene Ontology (GO) - Biological Process for CLLU1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLLU1 Gene

Drugs & Compounds for CLLU1 Gene

No Compound Related Data Available

Transcripts for CLLU1 Gene

mRNA/cDNA for CLLU1 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLLU1 Gene

No ASD Table

Relevant External Links for CLLU1 Gene

GeneLoc Exon Structure for
CLLU1
ECgene alternative splicing isoforms for
CLLU1

Expression for CLLU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLLU1 Gene

mRNA differential expression in normal tissues according to GTEx for CLLU1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CLLU1 Gene:

CLLU1

SOURCE GeneReport for Unigene cluster for CLLU1 Gene:

Hs.730377

mRNA Expression by UniProt/SwissProt for CLLU1 Gene:

Q5K131-CLLU1_HUMAN
Tissue specificity: Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patients before and after treatment.

Evidence on tissue expression from TISSUES for CLLU1 Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with CLLU1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLLU1 Gene

Orthologs for CLLU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLLU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLLU1 34
  • 98.07 (n)
Species where no ortholog for CLLU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLLU1 Gene

ENSEMBL:
Gene Tree for CLLU1 (if available)
TreeFam:
Gene Tree for CLLU1 (if available)

Paralogs for CLLU1 Gene

No data available for Paralogs for CLLU1 Gene

Variants for CLLU1 Gene

Sequence variations from dbSNP and Humsavar for CLLU1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000249161 -- 92,421,026(+) CCTGT(C/G)CTTCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000521040 -- 92,423,868(+) AAAGT(A/G)ATAAT intron-variant, upstream-variant-2KB
rs1000552162 -- 92,423,375(+) AATAA(A/G)CCTGC intron-variant, upstream-variant-2KB
rs1000705346 -- 92,429,366(+) GAGGA(A/G)CTCAG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000931101 -- 92,431,350(+) TGGGA(A/G)GTTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CLLU1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Variation tolerance for CLLU1 Gene

Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLLU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLLU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLLU1 Gene

Disorders for CLLU1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLLU1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search CLLU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLLU1

Genetic Association Database (GAD)
CLLU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLLU1
genes like me logo Genes that share disorders with CLLU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLLU1 Gene

Publications for CLLU1 Gene

  1. Recent de novo origin of human protein-coding genes. (PMID: 19726446) Knowles D.G. … McLysaght A. (Genome Res. 2009) 2 3 4 64
  2. De novo origin of human protein-coding genes. (PMID: 22102831) Wu D.D. … Zhang Y.P. (PLoS Genet. 2011) 2 3 64
  3. The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone. (PMID: 19212335) Buhl A.M. … Leffers H. (Leukemia 2009) 3 4 64
  4. CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia. (PMID: 17284524) Josefsson P. … Buhl A.M. (Blood 2007) 3 4 64
  5. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. (PMID: 16339396) Buhl A.M. … Leffers H. (Blood 2006) 3 4 64

Products for CLLU1 Gene

Sources for CLLU1 Gene

Content
Loading form....