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Aliases for CLLU1 Gene

Aliases for CLLU1 Gene

  • Chronic Lymphocytic Leukemia Up-Regulated 1 2 3 5

External Ids for CLLU1 Gene

Previous GeneCards Identifiers for CLLU1 Gene

  • GC12U900504
  • GC12P091341
  • GC12P092817
  • GC12P089882

Summaries for CLLU1 Gene

Entrez Gene Summary for CLLU1 Gene

  • The protein encoded by this gene is overexpressed in chronic lymphocytic leukemia (CLL) and serves as a good prognostic marker for the disease. Methylation of certain genes, including this one, have been associated with CLL. This gene is protein-coding in humans and non-protein coding in other primates. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CLLU1 Gene

CLLU1 (Chronic Lymphocytic Leukemia Up-Regulated 1) is a Protein Coding gene. Diseases associated with CLLU1 include Chronic Lymphocytic Leukemia and Leukemia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLLU1 Gene

Genomics for CLLU1 Gene

Regulatory Elements for CLLU1 Gene

Enhancers for CLLU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F092442 1.5 FANTOM5 Ensembl ENCODE 12 +23.9 23874 6.0 TBP WRNIP1 MAX EBF1 RELA POLR2A CBX5 EED ZNF143 ETV6 CLLU1 LOC100507616 C12orf74 BTG1 ENSG00000257252 EEA1 CLLU1OS
GH12F092028 1.6 FANTOM5 Ensembl ENCODE 4.3 -388.2 -388156 8.8 HDGF PKNOX1 MLX WRNIP1 SIN3A ARID4B YBX1 FEZF1 DMAP1 ZNF2 BTG1 LOC101928617 CLLU1 GC12P092067 LOC105369901
GH12F092459 1.6 FANTOM5 Ensembl ENCODE 3.5 +45.4 45373 13.8 HDGF PKNOX1 WRNIP1 FEZF1 YY1 GATA2 ZNF207 JUNB TBX21 ZNF623 CLLU1OS LOC100507616 C12orf74 CLLU1 BTG1 LOC105369904
GH12F092501 1.7 FANTOM5 Ensembl ENCODE 2.3 +83.1 83070 5.6 HDGF PKNOX1 MLX ARID4B SIN3A YY1 ZNF207 FOS NFYC JUNB BTG1 CLLU1 EEA1 LOC105369904 LOC100507616
GH12F092537 1.6 FANTOM5 Ensembl ENCODE 2.1 +121.6 121623 11.6 HDGF PKNOX1 ATF1 YBX1 YY1 CBX5 ZNF143 FOS ZHX2 JUNB LOC100507616 CLLU1OS BTG1 CLLU1 EEA1 LOC100132126 LOC105369905
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLLU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLLU1 Gene

92,421,531 bp from pter
92,431,002 bp from pter
9,472 bases
Plus strand

Genomic View for CLLU1 Gene

Genes around CLLU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLLU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLLU1 Gene

Proteins for CLLU1 Gene

  • Protein details for CLLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chronic lymphocytic leukemia up-regulated protein 1
    Protein Accession:

    Protein attributes for CLLU1 Gene

    121 amino acids
    Molecular mass:
    14228 Da
    Quaternary structure:
    No Data Available
    • This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp.
    • Tridimensional modeling predicts that it may interact with the IL-4 receptor.

neXtProt entry for CLLU1 Gene

Post-translational modifications for CLLU1 Gene

No Post-translational modifications

Other Protein References for CLLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLLU1 Gene

Domains & Families for CLLU1 Gene

Protein Domains for CLLU1 Gene


Suggested Antigen Peptide Sequences for CLLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLLU1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CLLU1 Gene

Function for CLLU1 Gene

Phenotypes for CLLU1 Gene

GenomeRNAi human phenotypes for CLLU1:
genes like me logo Genes that share phenotypes with CLLU1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLLU1 Gene

Localization for CLLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLLU1 Gene

Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.

Gene Ontology (GO) - Cellular Components for CLLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLLU1: view

No data available for Subcellular locations from COMPARTMENTS for CLLU1 Gene

Pathways & Interactions for CLLU1 Gene

SuperPathways for CLLU1 Gene

No Data Available

Interacting Proteins for CLLU1 Gene

Selected Interacting proteins: Q5K131-CLLU1_HUMAN for CLLU1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CLLU1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CLLU1 Gene

Transcripts for CLLU1 Gene

mRNA/cDNA for CLLU1 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLLU1 Gene

No ASD Table

Relevant External Links for CLLU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLLU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLLU1 Gene

mRNA differential expression in normal tissues according to GTEx for CLLU1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CLLU1 Gene:


SOURCE GeneReport for Unigene cluster for CLLU1 Gene:


mRNA Expression by UniProt/SwissProt for CLLU1 Gene:

Tissue specificity: Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patients before and after treatment.
genes like me logo Genes that share expression patterns with CLLU1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CLLU1 Gene

Orthologs for CLLU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLLU1 34
  • 98.07 (n)
Species where no ortholog for CLLU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLLU1 Gene

Gene Tree for CLLU1 (if available)
Gene Tree for CLLU1 (if available)

Paralogs for CLLU1 Gene

No data available for Paralogs for CLLU1 Gene

Variants for CLLU1 Gene

Sequence variations from dbSNP and Humsavar for CLLU1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10546326 -- 92,423,534(+) GACAC(-/CATT)CAAAG intron-variant, upstream-variant-2KB
rs10652564 -- 92,428,702(+) CCTTC(-/T)CTTCT intron-variant, upstream-variant-2KB
rs10652565 -- 92,428,820(+) TTTCT(-/CTCT)TTCTT intron-variant, upstream-variant-2KB
rs10745593 -- 92,426,705(+) AGTCA(A/T)CTTGG intron-variant
rs10859315 -- 92,428,716(+) TCTTC(C/T)TTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CLLU1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Variation tolerance for CLLU1 Gene

Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLLU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLLU1 Gene

Disorders for CLLU1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CLLU1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search CLLU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLLU1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CLLU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLLU1 Gene

Publications for CLLU1 Gene

  1. Recent de novo origin of human protein-coding genes. (PMID: 19726446) Knowles D.G. … McLysaght A. (Genome Res. 2009) 2 3 4 64
  2. The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone. (PMID: 19212335) Buhl A.M. … Leffers H. (Leukemia 2009) 3 4 64
  3. CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia. (PMID: 17284524) Josefsson P. … Buhl A.M. (Blood 2007) 3 4 64
  4. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. (PMID: 16339396) Buhl A.M. … Leffers H. (Blood 2006) 3 4 64
  5. CLLU1 expression has prognostic value in chronic lymphocytic leukemia after first-line therapy in younger patients and in those with mutated IGHV genes. (PMID: 22899580) Gonzalez D. … Catovsky D. (Haematologica 2013) 3 64

Products for CLLU1 Gene

Sources for CLLU1 Gene

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