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Aliases for CLLU1 Gene

Aliases for CLLU1 Gene

  • Chronic Lymphocytic Leukemia Up-Regulated 1 2 3

External Ids for CLLU1 Gene

Previous GeneCards Identifiers for CLLU1 Gene

  • GC12U900504
  • GC12P091341
  • GC12P092817
  • GC12P089882

Summaries for CLLU1 Gene

GeneCards Summary for CLLU1 Gene

CLLU1 (Chronic Lymphocytic Leukemia Up-Regulated 1) is a Protein Coding gene. Diseases associated with CLLU1 include mature b-cell neoplasm and chronic lymphocytic leukemia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLLU1 Gene

Genomics for CLLU1 Gene

Regulatory Elements for CLLU1 Gene

Genomic Location for CLLU1 Gene

Start:
92,421,531 bp from pter
End:
92,431,002 bp from pter
Size:
9,472 bases
Orientation:
Plus strand

Genomic View for CLLU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLLU1 Gene

Proteins for CLLU1 Gene

  • Protein details for CLLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K131-CLLU1_HUMAN
    Recommended name:
    Chronic lymphocytic leukemia up-regulated protein 1
    Protein Accession:
    Q5K131
    Secondary Accessions:

    Protein attributes for CLLU1 Gene

    Size:
    121 amino acids
    Molecular mass:
    14228 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein has no orthologs in other species and appears to be the product of a protein-coding gene which has arisen since divergence from chimp
    • Tridimensional modeling predicts that it may interact with the IL-4 receptor

neXtProt entry for CLLU1 Gene

Proteomics data for CLLU1 Gene at MOPED

Post-translational modifications for CLLU1 Gene

No Post-translational modifications

Other Protein References for CLLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLLU1 Gene

Domains for CLLU1 Gene

Protein Domains for CLLU1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CLLU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLLU1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CLLU1 Gene

Function for CLLU1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLLU1 Gene

Localization for CLLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLLU1 Gene

Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLLU1 Gene COMPARTMENTS Subcellular localization image for CLLU1 gene
Compartment Confidence
extracellular 3
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CLLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLLU1: view

Pathways for CLLU1 Gene

SuperPathways for CLLU1 Gene

No Data Available

Interacting Proteins for CLLU1 Gene

Gene Ontology (GO) - Biological Process for CLLU1 Gene

None

No data available for Pathways by source for CLLU1 Gene

Transcripts for CLLU1 Gene

mRNA/cDNA for CLLU1 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CLLU1 Gene

No ASD Table

Relevant External Links for CLLU1 Gene

GeneLoc Exon Structure for
CLLU1
ECgene alternative splicing isoforms for
CLLU1

Expression for CLLU1 Gene

mRNA expression in normal human tissues for CLLU1 Gene

mRNA differential expression in normal tissues according to GTEx for CLLU1 Gene

This gene is overexpressed in Muscle - Skeletal (5.4).

SOURCE GeneReport for Unigene cluster for CLLU1 Gene Hs.730377

mRNA Expression by UniProt/SwissProt for CLLU1 Gene

Q5K131-CLLU1_HUMAN
Tissue specificity: Specifically expressed in chronic lymphocytic leukemia (CLL) cells from patients without immunoglobulin heavy-chain hypermutations. Expression is detected in all CLL cells and levels are similar in patients before and after treatment.
genes like me logo Genes that share expressions with CLLU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CLLU1 Gene

Orthologs for CLLU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CLLU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLLU1 35
  • 98.07 (n)
  • 98.35 (a)
Species with no ortholog for CLLU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLLU1 Gene

ENSEMBL:
Gene Tree for CLLU1 (if available)
TreeFam:
Gene Tree for CLLU1 (if available)

Paralogs for CLLU1 Gene

No data available for Paralogs for CLLU1 Gene

Variants for CLLU1 Gene

Sequence variations from dbSNP and Humsavar for CLLU1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6538329 -- 92,430,817(+) actct(G/T)gttgt utr-variant-3-prime, nc-transcript-variant
rs7308198 -- 92,430,922(+) ataaa(A/C)tgagc utr-variant-3-prime, nc-transcript-variant
rs12300966 -- 92,431,496(+) atttt(A/T)aaaaa downstream-variant-500B
rs12578643 -- 92,430,297(+) GTATA(A/T)ACACC utr-variant-3-prime, nc-transcript-variant
rs17251627 -- 92,430,628(+) CTGTG(A/G)CTTGC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CLLU1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855

Relevant External Links for CLLU1 Gene

HapMap Linkage Disequilibrium report
CLLU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLLU1 Gene

Disorders for CLLU1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CLLU1 Gene including...

Search for CLLU1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLLU1 Gene

Relevant External Links for CLLU1

Genetic Association Database (GAD)
CLLU1
genes like me logo Genes that share disorders with CLLU1: view

No data available for UniProtKB/Swiss-Prot for CLLU1 Gene

Publications for CLLU1 Gene

  1. Recent de novo origin of human protein-coding genes. (PMID: 19726446) Knowles D.G. … McLysaght A. (Genome Res. 2009) 2 3 4
  2. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. (PMID: 16339396) Buhl A.M. … Leffers H. (Blood 2006) 3 4
  3. CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia. (PMID: 17284524) Josefsson P. … Buhl A.M. (Blood 2007) 3 4
  4. The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone. (PMID: 19212335) Buhl A.M. … Leffers H. (Leukemia 2009) 3 4
  5. The prognostic evaluation of CLLU1 expression levels in 50 Chinese patients with chronic lymphocytic leukemia. (PMID: 17786715) Chen L. … Xu W. (Leuk. Lymphoma 2007) 3

Products for CLLU1 Gene

Sources for CLLU1 Gene

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