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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK4 Gene

protein-coding   GIFtS: 55
GCID: GC05M177962

CDC-Like Kinase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDC-Like Kinase 41 2 3
EC 2.7.12.13 8
Dual Specificity Protein Kinase CLK42
Protein Serine Threonine Kinase Clk42

External Ids:    HGNC: 136591   Entrez Gene: 573962   Ensembl: ENSG000001132407   OMIM: 6079695   UniProtKB: Q9HAZ13   

Export aliases for CLK4 gene to outside databases

Previous GC identifers: GC05M178182 GC05M178917 GC05M178098 GC05M178143 GC05M172756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLK4 Gene:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can
interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important
role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing.
Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly
conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple
alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK4 Gene: 
CLK4 (CDC-like kinase 4) is a protein-coding gene. Diseases associated with CLK4 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3.
Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue
factor (F3) pre-mRNA in endothelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK4 gene promoter:
         TBP   HFH-3   AML1a   Nkx2-5   GATA-1   FOXI1   TFIID   FOXO4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

CLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M177962:  view genomic region     (about GC identifiers)

Start:
178,029,665 bp from pter      End:
178,057,616 bp from pter
Size:
27,952 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK4  
Size: 481 amino acids; 57492 Da
Subunit: Interacts with UBL5
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for CLK4: NX_Q9HAZ1

Explore proteomics data for CLK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylates on all three types of residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HAZ1

  • 3 DME Specific Peptides for CLK4 (Q9HAZ1)
     EHLAMMER  VSTRHYRAPEVIL  LTHTDLKPENILFV 

    CLK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLK4 Protein Expression
    REFSEQ proteins: NP_065717.1  
    ENSEMBL proteins: 
     ENSP00000316948   ENSP00000429195   ENSP00000428651   ENSP00000430216   ENSP00000430892  

    Human Recombinant Protein Products for CLK4: 
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    Novus Biologicals CLK4 Proteins
    Novus Biologicals CLK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLK4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CLK4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CLK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 4 
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAZ1

    ProtoNet protein and cluster: Q9HAZ1

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    CLK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK4_HUMAN, Q9HAZ1
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3.
    Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue
    factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated
    by phosphorylation of SR proteins (By similarity)

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    CLK4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLK4:
     Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLK4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLK4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLK4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLK4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidCLK4 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46


    1 BioSystems Pathway for CLK4
        mRNA processing


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CLK4 (Q9HAZ13 ENSP000003169484) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB2Q160823, ENSP000003024764I2D: score=1 STRING: ENSP00000302476
    CLASRPQ8N2M83, ENSP000002214554I2D: score=2 STRING: ENSP00000221455
    HSPB2-C11orf52Q160823I2D: score=1 
    UBL5Q9BZL13, ENSP000003514924I2D: score=3 STRING: ENSP00000351492
    SHBQ154643I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0043484regulation of RNA splicing IMP19168442
    GO:0046777protein autophosphorylation IEA--

    CLK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK4

    2 HMDB Compounds for CLK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CLK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLK4 gene: 
    NM_020666.2  

    Unigene Cluster for CLK4:

    CDC-like kinase 4
    Hs.406557  [show with all ESTs]
    Unigene Representative Sequence: BC151233
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520878(uc010jku.1 uc003mjh.1 uc011dgh.1 uc011dgj.1)
    ENST00000316308(uc003mjf.1 uc010jkv.1 uc011dgg.1) ENST00000522136
    ENST00000519132 ENST00000521621(uc003mjg.1) ENST00000519583(uc003mji.2)
    ENST00000522749 ENST00000520199(uc011dgi.1) ENST00000520909 ENST00000520126
    ENST00000522556(uc010jkw.1) ENST00000523013 ENST00000520957
    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidCLK4 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK4
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    GenScript: all cDNA clones in your preferred vector: CLK4 (NM_020666)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK4
    Sirion Biotech Customized lentivirus for stable overexpression of CLK4 
                         Customized lentivirus expression plasmids for stable overexpression of CLK4 
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    OriGene qPCR primer pairs and template standards for CLK4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLK4

    Additional mRNA sequence: 

    AF294429.1 AK294842.1 AK294921.1 AK304614.1 AK308578.1 AK308674.1 AK308879.1 AK309215.1 
    AK310427.1 AK311485.1 BC015942.1 BC034633.1 BC046211.1 BC063116.1 BC065732.1 BC136261.1 
    BC143538.1 BC143547.1 BC151233.1 BX647323.1 CR749504.1 

    13 DOTS entries:

    DT.210732  DT.440688  DT.100687389  DT.100734976  DT.99968874  DT.120803835  DT.100831424  DT.40200410 
    DT.97824908  DT.101961982  DT.40130625  DT.120803850  DT.120803853 

    24/109 AceView cDNA sequences (see all 109):

    CD722251 BQ774390 BC063116 AW611913 BX486932 AA631990 CD676847 AW071147 
    BC046211 BM727179 BC015942 BM786882 CA314357 NM_020666 AI811451 AF294429 
    BC034633 BP372921 BF439438 AI183343 BE045680 BM675318 BE886758 BP383242 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CLK4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
    SP1:                                            -     -     -     -     -     -     -                 -           -                                             
    SP2:                                            -     -     -     -     -     -     -                 -     -     -                                             
    SP3:                                                                                                                                                            
    SP4:                                            -           -     -     -     -                                                                                 
    SP5:                                            -     -     -     -     -     -     -                 -           -                                             

    ExUns: 13 ^ 14 ^ 15 ^ 16
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CLK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTCACCT
    CLK4 Expression
    About this image


    See CLK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK4

    SOURCE GeneReport for Unigene cluster: Hs.406557

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Tissue specificity: Expressed in liver, kidney, heart, muscle, brain and endothelial cells

        SABiosciences Custom PCR Arrays for CLK4
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK4 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk41 , 5 CDC like kinase 41, 5 90.64(n)1
    97.09(a)1
      11 (31.02 cM)5
    127501  NM_007714.51  NP_031740.11 
     512617305 
    chicken
    (Gallus gallus)
    Aves CLK41 CDC-like kinase 4 77.73(n)
    83.61(a)
      416295  XM_414614.3  XP_414614.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLK46
    CDC-like kinase 4
    74(a)
    1 ↔ 1
    2(141586195-141596736)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.174412 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_065717.1 (H.sapiens) protein serine threonine kinase Clk4 [Homo sapiens] less 78.99(n)    CF521596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clk4a1 CDC-like kinase 4a 63.52(n)
    63.94(a)
      321857  XM_003199840.1  XP_003199888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa3 NOT MAPKKK cascade protein
    serine/threonine kinase less
    60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform b
    22(a)
    1 → many
    X(14284868-14293993)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS11 Kns1p 50.73(n)
    43.05(a)
      850641   NP_013081.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FC11 serine/threonine-protein kinase AFC1 54.85(n)
    48.05(a)
      824525  NM_001035776.1  NP_001030853.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08379001 hypothetical protein 54.15(n)
    48.65(a)
      4327372  NM_001051277.1  NP_001044742.1 


    ENSEMBL Gene Tree for CLK4 (if available)
    TreeFam Gene Tree for CLK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK4 gene
    CLK32  PRPF4B2  CLK12  CLK22  
    6 SIMAP similar genes for CLK4 using alignment to 7 protein entries:     CLK4_HUMAN (see all proteins):
    DKFZp686A20267    CLK1    LOC402468    CLK2    CLK3    DKFZp564L2416

    CLK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/552 SNPs in CLK4 are shown (see all 552)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378680611,2
    --178029173(+) AAATTC/TACCTG 1 -- ds50010--------
    rs1855121121,2
    --178029453(+) ACAGGC/TGCCCG 1 -- ds50010--------
    rs1490426571,2
    C--178029474(+) CAGCAA/CTTTTT 1 -- ds50010--------
    rs1431758241,2
    --178029708(+) TGGAAA/GTTTCA 1 -- ut310--------
    rs1879888521,2
    --178029812(+) TCTTAC/TAGGTT 1 -- ut310--------
    rs1117371801,2
    F--178030036(+) AATGGG/ACAAAC 1 -- ut312Minor allele frequency- A:0.50CSA 4
    rs1920256771,2
    --178030155(+) TGGTTG/TCTAGT 1 -- ut310--------
    rs1846726361,2
    --178030290(+) TTTCCG/TTTTAC 1 -- ut310--------
    rs1885949021,2
    --178030295(+) TTTTAC/TTCAAA 1 -- ut310--------
    rs2012003341,2
    C--178030591(+) AGAAGG/TATATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLK4 (178029665 - 178057616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883214CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLK4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607969    OMIM disorders: --

    3 diseases for CLK4:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    endotheliitis


    CLK4 for disorders           About GeneDecksing


    Export disorders for CLK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CLK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35. (PubMed id 11170754)1, 2, 3 Schultz J.... Wallasch C. (2001)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PubMed id 12824502)1, 2 McNally T....Reilly R.M. (2003)
    5. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (2003)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    8. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57396 HGNC: 13659 AceView: CLK4 Ensembl:ENSG00000113240 euGenes: HUgn57396
    ECgene: CLK4 H-InvDB: CLK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLK4 gene:
    Search GeneIP for patents involving CLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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