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Aliases for CLK4 Gene

Aliases for CLK4 Gene

  • CDC-Like Kinase 4 2 3 4
  • EC 2.7.12.1 4 63

External Ids for CLK4 Gene

Previous GeneCards Identifiers for CLK4 Gene

  • GC05M178182
  • GC05M178917
  • GC05M178098
  • GC05M178143
  • GC05M177962
  • GC05M172756
  • GC05M178029

Summaries for CLK4 Gene

Entrez Gene Summary for CLK4 Gene

  • The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLK4 Gene

CLK4 (CDC-Like Kinase 4) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is PRPF4B.

UniProtKB/Swiss-Prot for CLK4 Gene

  • Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLK4 Gene

Genomics for CLK4 Gene

Regulatory Elements for CLK4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLK4 Gene

Start:
178,602,663 bp from pter
End:
178,630,615 bp from pter
Size:
27,953 bases
Orientation:
Minus strand

Genomic View for CLK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLK4 Gene

Proteins for CLK4 Gene

  • Protein details for CLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAZ1-CLK4_HUMAN
    Recommended name:
    Dual specificity protein kinase CLK4
    Protein Accession:
    Q9HAZ1
    Secondary Accessions:

    Protein attributes for CLK4 Gene

    Size:
    481 amino acids
    Molecular mass:
    57492 Da
    Quaternary structure:
    • Interacts with UBL5.

neXtProt entry for CLK4 Gene

Proteomics data for CLK4 Gene at MOPED

Selected DME Specific Peptides for CLK4 Gene

Post-translational modifications for CLK4 Gene

Other Protein References for CLK4 Gene

Domains for CLK4 Gene

Gene Families for CLK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAZ1

UniProtKB/Swiss-Prot:

CLK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
genes like me logo Genes that share domains with CLK4: view

Function for CLK4 Gene

Molecular function for CLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins.
UniProtKB/Swiss-Prot Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Enzyme Numbers (IUBMB) for CLK4 Gene

Gene Ontology (GO) - Molecular Function for CLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CLK4: view

Phenotypes for CLK4 Gene

genes like me logo Genes that share phenotypes with CLK4: view

Animal Model Products

miRNA for CLK4 Gene

miRTarBase miRNAs that target CLK4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLK4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CLK4 Gene

Localization for CLK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLK4 Gene COMPARTMENTS Subcellular localization image for CLK4 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CLK4: view

Pathways for CLK4 Gene

SuperPathways for CLK4 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CLK4: view

Pathways by source for CLK4 Gene

1 BioSystems pathway for CLK4 Gene

Gene Ontology (GO) - Biological Process for CLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0043484 regulation of RNA splicing IMP 19168442
GO:0046777 protein autophosphorylation IEA --
genes like me logo Genes that share ontologies with CLK4: view

Drugs for CLK4 Gene

(1) Tocris Compounds for CLK4 Gene

Compound Action Cas Number
TG 003 Potent, ATP-competitive inhibitor of Clk-family kinases [719277-26-6]

(2) HMDB Compounds for CLK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • Adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CLK4: view

Transcripts for CLK4 Gene

Unigene Clusters for CLK4 Gene

CDC-like kinase 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLK4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: -

ExUns: 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CLK4 Gene

GeneLoc Exon Structure for
CLK4
ECgene alternative splicing isoforms for
CLK4

Expression for CLK4 Gene

mRNA expression in normal human tissues for CLK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLK4 Gene

This gene is overexpressed in Brain - Cerebellum (6.4) and Brain - Cerebellar Hemisphere (6.0).

Protein differential expression in normal tissues for CLK4 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLK4 Gene

SOURCE GeneReport for Unigene cluster for CLK4 Gene Hs.406557

mRNA Expression by UniProt/SwissProt for CLK4 Gene

Q9HAZ1-CLK4_HUMAN
Tissue specificity: Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
genes like me logo Genes that share expressions with CLK4: view

Expression partners for CLK4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLK4 35
  • 95.29 (n)
  • 97.3 (a)
CLK4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLK4 35
  • 94.39 (n)
  • 98.13 (a)
CLK4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clk4 35
  • 90.64 (n)
  • 97.09 (a)
Clk4 16
Clk4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLK4 35
  • 99.65 (n)
  • 100 (a)
CLK4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLK4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves CLK4 35
  • 77.73 (n)
  • 83.61 (a)
CLK4 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLK4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4557 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17441 35
zebrafish
(Danio rerio)
Actinopterygii clk4a 35
  • 63.44 (n)
  • 64.21 (a)
clk4a 36
  • 58 (a)
ManyToMany
clk4b 36
  • 59 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1122 35
fruit fly
(Drosophila melanogaster)
Insecta Doa 37
  • 60 (a)
Doa 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-172 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KNS1 36
  • 23 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00230 35
  • 50.17 (n)
  • 44.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.719 36
  • 47 (a)
OneToMany
Species with no ortholog for CLK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLK4 Gene

ENSEMBL:
Gene Tree for CLK4 (if available)
TreeFam:
Gene Tree for CLK4 (if available)

Paralogs for CLK4 Gene

Paralogs for CLK4 Gene

genes like me logo Genes that share paralogs with CLK4: view

Variants for CLK4 Gene

Sequence variations from dbSNP and Humsavar for CLK4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs57862544 -- 178,626,559(+) GAATC(C/T)AGGGG intron-variant
rs57113765 -- 178,611,991(+) AGGAG(-/CT)CTCTT intron-variant
rs56336368 -- 178,612,429(+) ACCTC(A/G)GGAGC reference, synonymous-codon, nc-transcript-variant
rs56177248 -- 178,609,757(+) ATATA(-/TA)AATTA intron-variant
rs35899017 -- 178,618,475(+) TATAT(-/AT)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLK4 Gene

Variant ID Type Subtype PubMed ID
nsv883214 CNV Gain 21882294

Relevant External Links for CLK4 Gene

HapMap Linkage Disequilibrium report
CLK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLK4 Gene

Disorders for CLK4 Gene

No disorders were found for CLK4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CLK4 Gene

Publications for CLK4 Gene

  1. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35. (PMID: 11170754) Schultz J. … Wallasch C. (Genomics 2001) 2 3 4
  2. Beacon interacts with cdc2/cdc28-like kinases. (PMID: 12705895) Kantham L. … Collier G. (Biochem. Biophys. Res. Commun. 2003) 3 4
  3. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PMID: 12824502) McNally T. … Reilly R.M. (Protein Sci. 2003) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PMID: 19168442) Eisenreich A. … Rauch U. (Circ. Res. 2009) 3 4

Products for CLK4 Gene

Sources for CLK4 Gene

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