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CLK4 Gene

protein-coding   GIFtS: 55
GCID: GC05M178029

CDC-Like Kinase 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC-Like Kinase 41 2 3
EC 2.7.12.13 8
Dual Specificity Protein Kinase CLK42
Protein Serine Threonine Kinase Clk42

External Ids:    HGNC: 136591   Entrez Gene: 573962   Ensembl: ENSG000001132407   OMIM: 6079695   UniProtKB: Q9HAZ13   

Export aliases for CLK4 gene to outside databases

Previous GC identifers: GC05M178182 GC05M178917 GC05M178098 GC05M178143 GC05M177962 GC05M172756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLK4 Gene:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can
interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important
role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing.
Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly
conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple
alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK4 Gene:
CLK4 (CDC-like kinase 4) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3.
Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue
factor (F3) pre-mRNA in endothelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLK4 gene promoter:
         TBP   HFH-3   AML1a   Nkx2-5   GATA-1   FOXI1   TFIID   FOXO4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK4 promoter sequence
   Search Chromatin IP Primers for CLK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

CLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M178029:  view genomic region     (about GC identifiers)

Start:
178,029,665 bp from pter      End:
178,057,616 bp from pter
Size:
27,952 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK4  
Size: 481 amino acids; 57492 Da
Subunit: Interacts with UBL5

Explore the universe of human proteins at neXtProt for CLK4: NX_Q9HAZ1

Explore proteomics data for CLK4 at MOPED

Post-translational modifications: 

  • Autophosphorylates on all three types of residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CLK4 (Q9HAZ1)
     EHLAMMER  VSTRHYRAPEVIL  LTHTDLKPENILFV 


    See CLK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065717.1  
    ENSEMBL proteins: 
     ENSP00000316948   ENSP00000429195   ENSP00000428651   ENSP00000430216   ENSP00000430892  

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    Cloud-Clone Corp. Proteins for CLK4

     
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    antibodies-online proteins for CLK4 (6 products) 

     
    antibodies-online peptides for CLK4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 4
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAZ1

    ProtoNet protein and cluster: Q9HAZ1

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CLK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK4_HUMAN, Q9HAZ1
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3.
    Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue
    factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated
    by phosphorylation of SR proteins (By similarity)

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CLK4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLK4:
     Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CLK4

    miRNA
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    miRTarBase miRNAs that target CLK4:
    hsa-mir-192-5p (MIRT026138), hsa-mir-215-5p (MIRT024782)

    Block miRNA regulation of human, mouse, rat CLK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidCLK4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLK4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLK4_HUMAN, Q9HAZ1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with CLK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLK4 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44


    1 BioSystems Pathway for CLK4
        mRNA processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLK4
    Interactions:

        GeneGlobe Interaction Network for CLK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLK4 (Q9HAZ13 ENSP000003169484) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB2Q160823, ENSP000003024764I2D: score=1 STRING: ENSP00000302476
    CLASRPQ8N2M83, ENSP000002214554I2D: score=2 STRING: ENSP00000221455
    HSPB2-C11orf52Q160823I2D: score=1 
    UBL5Q9BZL13, ENSP000003514924I2D: score=3 STRING: ENSP00000351492
    SHBQ154643I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0018108peptidyl-tyrosine phosphorylation ----
    GO:0043484regulation of RNA splicing IMP19168442
    GO:0046777protein autophosphorylation IEA--

    Find genes that share ontologies with CLK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLK4

    2 HMDB Compounds for CLK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLK4 gene: 
    NM_020666.2  

    Unigene Cluster for CLK4:

    CDC-like kinase 4
    Hs.406557  [show with all ESTs]
    Unigene Representative Sequence: BC151233
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520878(uc010jku.1 uc003mjh.1 uc011dgh.1 uc011dgj.1)
    ENST00000316308(uc003mjf.1 uc010jkv.1 uc011dgg.1) ENST00000522136
    ENST00000519132 ENST00000521621(uc003mjg.1) ENST00000519583(uc003mji.2)
    ENST00000522749 ENST00000520199(uc011dgi.1) ENST00000520909 ENST00000520126
    ENST00000522556(uc010jkw.1) ENST00000523013 ENST00000520957
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidCLK4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CLK4
      QuantiFast Probe-based Assays in human, mouse, rat CLK4

    Additional mRNA sequence: 

    AF294429.1 AK294842.1 AK294921.1 AK304614.1 AK308578.1 AK308674.1 AK308879.1 AK309215.1 
    AK310427.1 AK311485.1 BC015942.1 BC034633.1 BC046211.1 BC063116.1 BC065732.1 BC136261.1 
    BC143538.1 BC143547.1 BC151233.1 BX647323.1 CR749504.1 

    13 DOTS entries:

    DT.210732  DT.440688  DT.100687389  DT.100734976  DT.99968874  DT.120803835  DT.100831424  DT.40200410 
    DT.97824908  DT.101961982  DT.40130625  DT.120803850  DT.120803853 

    Selected AceView cDNA sequences (see all 109):

    NM_020666 BQ774390 AW611913 AF294429 AI811451 BC046211 AW071147 BC034633 
    AI183343 BX486932 CD676847 BF439438 CA314357 BP372921 BC015942 BC063116 
    BM786882 AA631990 BM727179 CD722251 BX114030 BF431954 AI004959 CB177905 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLK4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
    SP1:                                            -     -     -     -     -     -     -                 -           -                                             
    SP2:                                            -     -     -     -     -     -     -                 -     -     -                                             
    SP3:                                                                                                                                                            
    SP4:                                            -           -     -     -     -                                                                                 
    SP5:                                            -     -     -     -     -     -     -                 -           -                                             

    ExUns: 13 ^ 14 ^ 15 ^ 16
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CLK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTCACCT
    CLK4 Expression
    About this image


    CLK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    CLK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406557

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Tissue specificity: Expressed in liver, kidney, heart, muscle, brain and endothelial cells

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk41 , 5 CDC like kinase 41, 5 90.64(n)1
    97.09(a)1
      11 (31.02 cM)5
    127501  NM_007714.51  NP_031740.11 
     512617305 
    chicken
    (Gallus gallus)
    Aves CLK41 CDC-like kinase 4 77.73(n)
    83.61(a)
      416295  XM_414614.4  XP_414614.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLK46
    CDC-like kinase 4
    74(a)
    1 ↔ 1
    2(141586195-141596736)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.174412 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_065717.1 (H.sapiens) protein serine threonine kinase Clk4 [Homo sapiens] less 78.99(n)    CF521596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clk4a1 CDC-like kinase 4a 63.44(n)
    64.21(a)
      321857  XM_003199840.2  XP_003199888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa3 NOT MAPKKK cascade protein
    serine/threonine kinase less
    60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform a (tag-172) mRNA, complet...
    23(a)
    1 → many
    X(14284868-14293993) WBGene00006517
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    23(a)
    1 → many
    XII(105686-107899) YLL019C
    soybean
    (Glycine max)
    eudicotyledons 445053862   -- 78.12(n)  


    ENSEMBL Gene Tree for CLK4 (if available)
    TreeFam Gene Tree for CLK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLK4 gene
    CLK32  PRPF4B2  CLK12  CLK22  
    6 SIMAP similar genes for CLK4 using alignment to 7 protein entries:     CLK4_HUMAN (see all proteins):
    DKFZp686A20267    CLK1    LOC402468    CLK2    CLK3    DKFZp564L2416

    Find genes that share paralogs with CLK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLK4 (see all 552)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378680611,2
    --178029173(+) AAATTC/TACCTG 1 -- ds50010--------
    rs1855121121,2
    --178029453(+) ACAGGC/TGCCCG 1 -- ds50010--------
    rs1490426571,2
    C--178029474(+) CAGCAA/CTTTTT 1 -- ds50010--------
    rs1431758241,2
    --178029708(+) TGGAAA/GTTTCA 1 -- ut310--------
    rs1879888521,2
    --178029812(+) TCTTAC/TAGGTT 1 -- ut310--------
    rs1117371801,2
    F--178030036(+) AATGGG/ACAAAC 1 -- ut312Minor allele frequency- A:0.50CSA 4
    rs1920256771,2
    --178030155(+) TGGTTG/TCTAGT 1 -- ut310--------
    rs1846726361,2
    --178030290(+) TTTCCG/TTTTAC 1 -- ut310--------
    rs1885949021,2
    --178030295(+) TTTTAC/TTCAAA 1 -- ut310--------
    rs2012003341,2
    C--178030591(+) AGAAGG/TATATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLK4 (178029665 - 178057616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CLK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883214CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLK4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607969    OMIM disorders: --


    Find genes that share disorders with CLK4           About GenesLikeMe


    Export disorders for CLK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLK4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CLK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35. (PubMed id 11170754)1, 2, 3 Schultz J.... Wallasch C. (Genomics 2001)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A.... Rauch U. (Circ. Res. 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PubMed id 12824502)1, 2 McNally T....Reilly R.M. (Protein Sci. 2003)
    5. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (Biochem. Biophys. Res. Commun. 2003)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57396 HGNC: 13659 AceView: CLK4 Ensembl:ENSG00000113240 euGenes: HUgn57396
    ECgene: CLK4 H-InvDB: CLK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLK4 gene:
    Search GeneIP for patents involving CLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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