Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK4 Gene

protein-coding   GIFtS: 51
GCID: GC05M177962

CDC-like kinase 4
 Explore 4 diseases affiliated with
CLK4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLK4    

Aliases
for CLK4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CDC-Like Kinase 41 2 3
EC 2.7.12.13 8
Dual Specificity Protein Kinase CLK42
Protein Serine Threonine Kinase Clk42

External Ids:    HGNC: 136591   Entrez Gene: 573962   Ensembl: ENSG000001132407   OMIM: 6079695   UniProtKB: Q9HAZ13   

Export aliases for CLK4 gene to outside databases

Previous GC identifers: GC05M178182 GC05M178917 GC05M178098 GC05M178143 GC05M172756


Summaries
for CLK4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLK4:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact
with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the
formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli
sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like
protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript
variants have been observed, but the full-length natures of which have not yet been determined. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of
regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for
the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA
in endothelial cells




Genomic Views
for CLK4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK4 gene promoter:
         TBP   HFH-3   AML1a   Nkx2-5   GATA-1   FOXI1   TFIID   FOXO4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

CLK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M177962:  view genomic region     (about GC identifiers)

Start:
 178,029,665 bp from pter      End:
 178,057,616 bp from pter
Size:
 27,952 bases      Orientation:
 minus strand

Proteins
for CLK4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK4  
Size: 481 amino acids; 57492 Da
Subunit: Interacts with UBL5
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for CLK4: NX_Q9HAZ1

Post-translational modifications:

  • Autophosphorylates on all three types of residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAZ1

    • 3 DME Specific Peptides for CLK4 (Q9HAZ1)
     EHLAMMER  VSTRHYRAPEVIL  LTHTDLKPENILFV 

    CLK4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065717.1  
    ENSEMBL proteins: 
     ENSP00000316948   ENSP00000429195   ENSP00000428651   ENSP00000430216   ENSP00000430892  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CLK4 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CLK4 
    GenScript Custom Purified and Recombinant Proteins Services for CLK4
    Novus Biologicals CLK4 Proteins
    Novus Biologicals CLK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLK4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    CLK4 for ontologies           About GeneDecksing



    CLK4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLK4 
    GenScript Custom Superior Antibodies Services for CLK4
    Novus Biologicals CLK4 Antibodies
    Search for Antibodies for CLK4 at Abcam  
    Uscn Antibodies for CLK4
    ThermoFisher Antibodies for CLK4

    Assay Products for CLK4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLK4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CLK4

    Protein Domains /
    Families
    for CLK4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLK4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAZ1

    ProtoNet protein and cluster: Q9HAZ1

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CLK4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
    serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of
    regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for
    the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA
    in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated by
    phosphorylation of SR proteins (By similarity)

    Enzyme Number (IUBMB): EC 2.7.12.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CLK4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLK4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: CLK4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK4 (see all 7)
    OriGene shRNA RFP: CLK4
    OriGene siRNA: CLK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLK4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLK4 (NM_020666)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CLK4
    Search LifeMap BioReagents cell lines for CLK4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--


    CLK4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CLK4:
     Decreased substrate adherent c  Increased cell death HMECs cel 


    Pathways & Interactions
    for CLK4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA processing0.48


    1 BioSystems Pathway for CLK4 
        mRNA processing


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for CLK4 (Q9HAZ13 ENSP000003169484) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLASRPQ8N2M83, ENSP000002214554I2D: score=2 STRING: ENSP00000221455
    UBL5Q9BZL13, ENSP000003514924I2D: score=3 STRING: ENSP00000351492
    HSPB2Q160823, ENSP000003024764I2D: score=1 STRING: ENSP00000302476
    SHBQ154643I2D: score=1 
    JMJD6ENSP000003940854STRING: ENSP00000394085
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0043484regulation of RNA splicing IMP19168442
    GO:0046777protein autophosphorylation IEA--


    CLK4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLK4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK4

    2 HMDB Compounds for CLK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about CLK4 

    Transcripts
    for CLK4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLK4 gene: 
    NM_020666.2  

    Unigene Cluster for CLK4:

    CDC-like kinase 4
    Hs.406557  [show with all ESTs]
    Unigene Representative Sequence: BC151233
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520878(uc010jku.1 uc003mjh.1 uc011dgh.1 uc011dgj.1)
    ENST00000316308(uc003mjf.1 uc010jkv.1 uc011dgg.1) ENST00000522136
    ENST00000519132 ENST00000521621(uc003mjg.1) ENST00000519583(uc003mji.2)
    ENST00000522749 ENST00000520199(uc011dgi.1) ENST00000520909 ENST00000520126
    ENST00000522556(uc010jkw.1) ENST00000523013 ENST00000520957

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLK4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLK4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK4 (see all 37):
    hsa-miR-374a* hsa-miR-3667-5p hsa-miR-3658 hsa-miR-186 hsa-miR-3613-3p hsa-miR-34b hsa-miR-23a hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: CLK4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK4 (see all 7)
    OriGene shRNA RFP: CLK4
    OriGene siRNA: CLK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLK4 (NM_020666)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLK4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLK4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLK4

    Additional cDNA sequence: 

    AF294429.1 AK294842.1 AK294921.1 AK304614.1 AK308578.1 AK308674.1 AK308879.1 AK309215.1 
    AK310427.1 AK311485.1 BC015942.1 BC034633.1 BC046211.1 BC063116.1 BC065732.1 BC136261.1 
    BC143538.1 BC143547.1 BC151233.1 BX647323.1 CR749504.1 

    13 DOTS entries:

    DT.210732  DT.440688  DT.100687389  DT.100734976  DT.99968874  DT.120803835  DT.100831424  DT.40200410 
    DT.97824908  DT.101961982  DT.40130625  DT.120803850  DT.120803853 

    24/109 AceView cDNA sequences (see all 109):

    AF294429 BC046211 NM_020666 AA631990 BX486932 BP372921 AI183343 BQ774390 
    BC034633 AW611913 BC063116 BF439438 BM786882 CD676847 AI811451 CD722251 
    BC015942 CA314357 AW071147 BM727179 BE886758 N68012 CB127989 CD000155 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CLK4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
    SP1:                                            -     -     -     -     -     -     -                 -           -                                             
    SP2:                                            -     -     -     -     -     -     -                 -     -     -                                             
    SP3:                                                                                                                                                            
    SP4:                                            -           -     -     -     -                                                                                 
    SP5:                                            -     -     -     -     -     -     -                 -           -                                             

    ExUns: 13 ^ 14 ^ 15 ^ 16
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CLK4

    Expression
    for CLK4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGTCACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK4

    SOURCE GeneReport for Unigene cluster: Hs.406557

    UniProtKB/Swiss-Prot: CLK4_HUMAN, Q9HAZ1
    Tissue specificity: Expressed in liver, kidney, heart, muscle, brain and endothelial cells

        SABiosciences Custom PCR Arrays for CLK4
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLK4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLK4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLK4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLK4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4

    Orthologs
    for CLK4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK4 gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clk41 , 5 CDC like kinase 41, 5 90.64(n)1
    97.09(a)1    		   11 (31.02 cM)5
    127501  NM_007714.51  NP_031740.11 
     512617305 
    chicken
    (Gallus gallus)    		 Aves CLK41 CDC-like kinase 4 77.73(n)
    83.61(a)    		   416295  XM_414614.3  XP_414614.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CLK46
    		 --
    		 74(a)
    		 1 ↔ 1
    		 2(141587365-141596703)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.174412 Xenopus laevis transcribed sequence with moderate similarity more 78.99(n)    CF521596.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii clk4a1 CDC-like kinase 4a 63.52(n)
    63.94(a)    		   321857  XM_003199840.1  XP_003199888.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Doa3 NOT MAPKKK cascade protein serine/threonine
    kinase    		 60(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1726
    		 Temporarily Assigned Gene name family member (tag-...
    		 22(a)
    		 1 → many
    		 X(14284798-14293923)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes KNS11 Kns1p 50.73(n)
    43.05(a)    		   850641   NP_013081.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons FC11 serine/threonine-protein kinase AFC1 54.85(n)
    48.05(a)    		   824525  NM_001035776.1  NP_001030853.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g08379001 hypothetical protein 54.15(n)
    48.65(a)    		   4327372  NM_001051277.1  NP_001044742.1 


    ENSEMBL Gene Tree for CLK4 (if available)
    TreeFam Gene Tree for CLK4 (if available) 

    Paralogs
    for CLK4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK4 gene
    CLK32  PRPF4B2  CLK12  CLK22  
    6 SIMAP similar genes for CLK4 using alignment to 7 protein entries:     CLK4_HUMAN (see all proteins):
    DKFZp686A20267    CLK1    LOC402468    CLK2    CLK3    DKFZp564L2416

    CLK4 for paralogs           About GeneDecksing



    Genomic Variants
    for CLK4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 NCBI SNPs in CLK4 are shown (see all 441)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1378680611,2
    		--178029173(+) AAATTC/TACCTG 1 -- ds50010--------
    rs1855121121,2
    		--178029453(+) ACAGGC/TGCCCG 1 -- ds50010--------
    rs1490426571,2
    		--178029474(+) CAGCAA/CTTTTT 1 -- ds50010--------
    rs1431758241,2
    		--178029708(+) TGGAAA/GTTTCA 1 -- ut310--------
    rs1879888521,2
    		--178029812(+) TCTTAC/TAGGTT 1 -- ut310--------
    rs1117371801,2
    		F--178030036(+) AATGGG/ACAAAC 1 -- ut312Minor allele frequency- A:0.50CSA 4
    rs1920256771,2
    		--178030155(+) TGGTTG/TCTAGT 1 -- ut310--------
    rs1846726361,2
    		--178030290(+) TTTCCG/TTTTAC 1 -- ut310--------
    rs1885949021,2
    		--178030295(+) TTTTAC/TTCAAA 1 -- ut310--------
    rs2012003341,2
    		--178030591(+) AGAAGG/TATATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLK4 (178029665 - 178057616 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLK4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLK4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK4

    Disorders / Diseases
    for CLK4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLK4 for disorders           About GeneDecksing

    OMIM gene information: 607969    OMIM disorders: --

    4 diseases for CLK4:    About MalaCards
    dna topoisomerase i    intrahepatic cholangiocarcinoma    cholangiocarcinoma    malaria


    Export disorders for CLK4 gene to outside databases

    Publications
    for CLK4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK4 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CLK4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35. (PubMed id 11170754)1, 2, 3 Schultz J.... Wallasch C. (2001)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PubMed id 12824502)1, 2 McNally T....Reilly R.M. (2003)
    5. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (2003)
    6. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    7. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)

    External Searches for CLK4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLK4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57396 HGNC: 13659 AceView: CLK4 Ensembl:ENSG00000113240 euGenes: HUgn57396
    ECgene: CLK4 H-InvDB: CLK4

    Other Databases showing CLK4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLK4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLK4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLK4 gene:
    Search GeneIP for patents involving CLK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLK4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant CLK4 Protein
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CLK4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLK4  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CLK4   OriGene 3'-UTR Clone for CLK4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLK4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLK4   OriGene Custom Protein Services for CLK4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLK4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLK4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLK4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLK4
     GenScript Custom Purified and Recombinant Proteins Services for CLK4 GenScript cDNA clones with any tag delivered in your preferred vector for CLK4
     GenScript Custom Assay Services for CLK4 GenScript Custom Superior Antibodies Services for CLK4
     GenScript Custom overexpressing Cell Line Services for CLK4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLK4 promoter
     Search Chromatin IP Primers for CLK4
     RT2 qPCR Primer Assay in human, mouse, rat CLK4
     GNC Network for CLK4
     SABiosciences Custom PCR Arrays for CLK4
     Search Tocris compounds for CLK4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLK4 antibodies
     CLK4 proteins
     CLK4 lysates
     Search for Antibodies for CLK4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CLK4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CLK4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CLK4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK4
     SwitchGear 3'UTR luciferase reporter plasmids for CLK4
     SwitchGear Promoter luciferase reporter plasmids for CLK4
     ThermoFisher Antibodies for CLK4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CLK4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4