Aliases for CLK3 Gene
External Ids for CLK3 Gene
Previous GeneCards Identifiers for CLK3 Gene
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLK3 Gene
CLK3 (CDC-Like Kinase 3) is a Protein Coding gene. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is CLK4.
UniProtKB/Swiss-Prot for CLK3 Gene
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
CLKs (Cdc2-like kinase)are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events.