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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK3 Gene

protein-coding   GIFtS: 62
GCID: GC15P074900

CDC-Like Kinase 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDC-Like Kinase 31 2 3
EC 2.7.12.13 8
PHCLK32
PHCLK3/1522
Dual Specificity Protein Kinase CLK32

External Ids:    HGNC: 20711   Entrez Gene: 11982   Ensembl: ENSG000001793357   OMIM: 6029905   UniProtKB: P497613   

Export aliases for CLK3 gene to outside databases

Previous GC identifers: GC15U990010 GC15P068014 GC15P072476 GC15P072616 GC15P072687 GC15P051698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLK3 Gene:
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a
nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR)
family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene.
Related pseudogenes are located on chromosomes 1 and 9. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK3 Gene: 
CLK3 (CDC-like kinase 3) is a protein-coding gene. Diseases associated with CLK3 include endotheliitis, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is PRPF4B.

UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the
alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

Gene Wiki entry for CLK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK3 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24

CLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P074900:  view genomic region     (about GC identifiers)

Start:
74,890,841 bp from pter      End:
74,932,057 bp from pter
Size:
41,217 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK3  
Size: 638 amino acids; 73515 Da
Subcellular location: Isoform 1: Nucleus. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle,
acrosome (By similarity)
Subcellular location: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins
in the nuclear speckles
Sequence caution: Sequence=AAH02555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH19881.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
5 PDB 3D structures from and Proteopedia for CLK3:
2EU9 (3D)        2EXE (3D)        2WU6 (3D)        2WU7 (3D)        3RAW (3D)    
Secondary accessions: D3DW59 Q53Y48 Q9BRS3 Q9BUJ7
Alternative splicing: 4 isoforms:  P49761-4   P49761-1   P49761-2   P49761-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK3: NX_P49761

Explore proteomics data for CLK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylates on all three types of residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49761

  • 4/11 DME Specific Peptides for CLK3 (P49761) (see all 11)
     VALKIIRN  MMEKILGP  TRKQKYFY  GFTLFQTH 

    CLK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLK3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123500.1  NP_003983.2  

    ENSEMBL proteins: 
     ENSP00000344112   ENSP00000431825   ENSP00000456399   ENSP00000378505   ENSP00000456278  
     ENSP00000455762   ENSP00000457362   ENSP00000457936   ENSP00000457696   ENSP00000455905  
     ENSP00000458099   ENSP00000456202   ENSP00000454785   ENSP00000454961   ENSP00000456431  
     ENSP00000323106   ENSP00000321136  

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    Cloud-Clone Corp. Proteins for CLK3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0045111intermediate filament cytoskeleton IDA--

    CLK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 3 
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49761

    ProtoNet protein and cluster: P49761

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    CLK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK3_HUMAN, P49761
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
    SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the
    alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing
    mediated by phosphorylation of SR proteins

         Genatlas biochemistry entry for CLK3:
    CDC-like kinase 3,with two alternatively spliced forms,one catalytically active and one inactive
    isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely
    expressed

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI16189514
         
    CLK3 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CLK3:
     Decreased influenza A virus in  Decreased substrate adherent c  Decreased telomerase activity  G0/1 arrest 
     Gemcitabine induced cell-death  Increased G1 DNA content  Increased apoptosis 

         1 MGI phenotypic allele for Clk3 (no phenotypes)

    CLK3 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCLK3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    2Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CLK3
        Translational Control

    1 BioSystems Pathway for CLK3
        mRNA processing




    CLK3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLK3

    5/6 Interacting proteins for CLK3 (P497612, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1orf63Q9BUV02, 3MINT-66690 I2D: score=5 
    YWHAGP619812, 3MINT-50806 I2D: score=4 
    CLK2P497603I2D: score=5 
    TERF1P542743I2D: score=1 
    TERF2Q155543I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9637771
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0043484regulation of RNA splicing IDA9637771
    GO:0046777protein autophosphorylation IEA--

    CLK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK3

    2 DrugBank Compounds for CLK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CLK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLK3 gene (3 alternative transcripts): 
    NM_001130028.1  NM_003992.4  NM_001292.1  

    Unigene Cluster for CLK3:

    CDC-like kinase 3
    Hs.584748  [show with all ESTs]
    Unigene Representative Sequence: CR933693
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000564353(uc002ayf.1) ENST00000567992 ENST00000345005(uc002ayg.4 uc002ayj.4)
    ENST00000483723(uc002ayh.4) ENST00000562389 ENST00000395066(uc010uln.2)
    ENST00000454830(uc010ulm.1 uc002ayk.4) ENST00000569063 ENST00000568139
    ENST00000563297 ENST00000568488 ENST00000568605 ENST00000566126 ENST00000570296
    ENST00000562670 ENST00000564096 ENST00000569406 ENST00000563112
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    hsa-miR-130a* hsa-miR-4297 hsa-miR-23c hsa-miR-218 hsa-miR-23b hsa-miR-1208 hsa-miR-23a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLK3 3' UTR sequence
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    Additional mRNA sequence: 

    AB209535.1 AK026511.1 AK091692.1 AK225680.1 AK291983.1 AK301689.1 BC002555.2 BC006103.1 
    BC009857.2 BC019881.1 BT006993.1 CR933693.1 L29217.1 

    24 DOTS entries:

    DT.95259401  DT.446374  DT.100038070  DT.91775585  DT.95259405  DT.40115428  DT.100845294  DT.91775594 
    DT.100038071  DT.91989003  DT.91775584  DT.100845297  DT.95259403  DT.95259412  DT.100845303  DT.121044184 
    DT.121044297  DT.121203462  DT.75106585  DT.95130106  DT.95312622  DT.97785184  DT.100791675  DT.97826548 

    24/375 AceView cDNA sequences (see all 375):

    BU538388 BM720315 BQ025125 CA424049 CA435561 AK122860 BX646144 BE408181 
    BQ648914 BQ056641 BG259636 AK096115 AI188106 BQ056351 AW849274 AI342362 
    AI268748 CA454349 AA364944 BE408194 BQ684621 BC002555 AU136614 AI355332 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CLK3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                -                 -                                                           -                                             
    SP4:                                -                 -     -     -                                               -                                             
    SP5:                                                  -                                                           -                                             

    ExUns: 14a · 14b · 14c ^ 15a · 15b
    SP1:        -     -               
    SP2:        -     -               
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CLK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK3 expression in normal human tissues (normalized intensities)      CLK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATGGA
    CLK3 Expression
    About this image


    CLK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract

    See CLK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK3

    SOURCE GeneReport for Unigene cluster: Hs.584748

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Tissue specificity: Endothelial cells

        SABiosciences Custom PCR Arrays for CLK3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CLK3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk31 , 5 CDC-like kinase 31, 5 86.94(n)1
    88.4(a)1
      9 (31.47 cM)5
    1024141  NM_007713.41  NP_031739.31 
     577507115 
    chicken
    (Gallus gallus)
    Aves CLK31 CDC-like kinase 3 78.58(n)
    86.24(a)
      415295  NM_001012524.2  NP_001012542.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLK36
    CDC-like kinase 3
    87(a)
    1 ↔ 1
    GL343721.1(146799-161035)
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa6
    Darkener of apricot
    12(a)
    1 → many
    3R(24713799-24748494)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform b
    23(a)
    1 → many
    X(14284868-14293993)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    20(a)
    1 → many
    XII(105686-107899)


    ENSEMBL Gene Tree for CLK3 (if available)
    TreeFam Gene Tree for CLK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK3 gene
    PRPF4B2  CLK12  CLK42  CLK22  
    5 SIMAP similar genes for CLK3 using alignment to 15 protein entries:     CLK3_HUMAN (see all proteins):
    LOC402468    CLK2    CLK1    CLK4    DYRK4

    CLK3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CLK3
    PGOHUM00000259538 PGOHUM00000235982


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/408 SNPs in CLK3 are shown (see all 408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404134
    ----see VAR_0404132 R C mis40--------
    VAR_0455804
    ----see VAR_0455802 R W mis40--------
    VAR_0455794
    ----see VAR_0455792 Q R mis40--------
    rs1162813591,2
    C,F--74898767(+) TCCTGG/CGTTGG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs752688231,2
    C,F--74898806(+) AATGGC/ACTGGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1830454641,2
    --74899090(+) AACAAA/GCAAAA 1 -- us2k10--------
    rs1887619011,2
    C--74899091(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs116332081,2
    C,F,H--74899095(+) ACAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.33WA NA CSA 6
    rs608392241,2
    C--74899130(+) TTTTC-/CTCTGTA 1 -- us2k10--------
    rs1869633011,2
    --74899278(+) TTTTCC/TTTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLK3 (74890841 - 74932057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv527730CNV Loss19592680
    nsv904379CNV Loss21882294
    nsv457204CNV Loss19166990
    esv28499CNV Gain19812545
    nsv817698CNV Gain17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602990    OMIM disorders: --

    2 diseases for CLK3:    About MalaCards
    endotheliitis    


    CLK3 for disorders           About GeneDecksing


    Export disorders for CLK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CLK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3 Hanes J.J.... Scheit K.H. (1994)
    2. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2, 9 Duncan P.I.... Bell J.C. (1998)
    3. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (1998)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1198 HGNC: 2071 AceView: CLK3 Ensembl:ENSG00000179335 euGenes: HUgn1198
    ECgene: CLK3 H-InvDB: CLK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLK3 gene:
    Search GeneIP for patents involving CLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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