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Aliases for CLK3 Gene

Aliases for CLK3 Gene

  • CDC-Like Kinase 3 2 3 4
  • EC 2.7.12.1 4 63
  • Dual Specificity Protein Kinase CLK3 3
  • PHCLK3/152 3
  • PHCLK3 3

External Ids for CLK3 Gene

Previous GeneCards Identifiers for CLK3 Gene

  • GC15U990010
  • GC15P068014
  • GC15P072476
  • GC15P072616
  • GC15P072687
  • GC15P074900
  • GC15P051698

Summaries for CLK3 Gene

Entrez Gene Summary for CLK3 Gene

  • This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLK3 Gene

CLK3 (CDC-Like Kinase 3) is a Protein Coding gene. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is CLK4.

UniProtKB/Swiss-Prot for CLK3 Gene

  • Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Tocris Summary for CLK3 Gene

  • CLKs (Cdc2-like kinase)�are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events.

Gene Wiki entry for CLK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLK3 Gene

Genomics for CLK3 Gene

Regulatory Elements for CLK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLK3 Gene

Start:
74,598,500 bp from pter
End:
74,645,414 bp from pter
Size:
46,915 bases
Orientation:
Plus strand

Genomic View for CLK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLK3 Gene

Proteins for CLK3 Gene

  • Protein details for CLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49761-CLK3_HUMAN
    Recommended name:
    Dual specificity protein kinase CLK3
    Protein Accession:
    P49761
    Secondary Accessions:
    • D3DW59
    • Q53Y48
    • Q9BRS3
    • Q9BUJ7

    Protein attributes for CLK3 Gene

    Size:
    638 amino acids
    Molecular mass:
    73515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH19881.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLK3 Gene

    Alternative splice isoforms for CLK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLK3 Gene

Proteomics data for CLK3 Gene at MOPED

Post-translational modifications for CLK3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CLK3 (CLK3)

Domains for CLK3 Gene

Gene Families for CLK3 Gene

HGNC:
  • CLK :CDC-like kinases
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P49761

UniProtKB/Swiss-Prot:

CLK3_HUMAN :
  • P49761
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
genes like me logo Genes that share domains with CLK3: view

Function for CLK3 Gene

Molecular function for CLK3 Gene

GENATLAS Biochemistry: CDC-like kinase 3,with two alternatively spliced forms,one catalytically active and one inactive isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely expressed
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins
UniProtKB/Swiss-Prot Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Enzyme Numbers (IUBMB) for CLK3 Gene

Gene Ontology (GO) - Molecular Function for CLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CLK3: view
genes like me logo Genes that share phenotypes with CLK3: view

Animal Model Products

CRISPR Products

miRNA for CLK3 Gene

miRTarBase miRNAs that target CLK3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CLK3 Gene

Localization for CLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLK3 Gene

Isoform 1: Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.
Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLK3 Gene COMPARTMENTS Subcellular localization image for CLK3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 9637771
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with CLK3: view

Pathways for CLK3 Gene

genes like me logo Genes that share pathways with CLK3: view

Pathways by source for CLK3 Gene

1 Cell Signaling Technology pathway for CLK3 Gene
1 BioSystems pathway for CLK3 Gene

Gene Ontology (GO) - Biological Process for CLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9637771
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0043484 regulation of RNA splicing IDA 9637771
GO:0046777 protein autophosphorylation IEA --
genes like me logo Genes that share ontologies with CLK3: view

Transcripts for CLK3 Gene

Unigene Clusters for CLK3 Gene

CDC-like kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLK3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^
SP1: -
SP2:
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - -
SP10: - - - - - -
SP11:
SP12: -
SP13: - - - - -
SP14: -

ExUns: 14a · 14b · 14c ^ 15a · 15b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CLK3 Gene

GeneLoc Exon Structure for
CLK3
ECgene alternative splicing isoforms for
CLK3

Expression for CLK3 Gene

mRNA expression in normal human tissues for CLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLK3 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLK3 Gene

SOURCE GeneReport for Unigene cluster for CLK3 Gene Hs.584748

mRNA Expression by UniProt/SwissProt for CLK3 Gene

P49761-CLK3_HUMAN
Tissue specificity: Endothelial cells.
genes like me logo Genes that share expressions with CLK3: view

In Situ Assay Products

Orthologs for CLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLK3 35
  • 99.73 (n)
  • 99.8 (a)
CLK3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLK3 35
  • 95.58 (n)
  • 98.57 (a)
CLK3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLK3 35
  • 94.35 (n)
  • 99.18 (a)
CLK3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clk3 35
  • 86.94 (n)
  • 88.4 (a)
Clk3 16
Clk3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLK3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLK3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clk3 35
  • 92.93 (n)
  • 98.78 (a)
chicken
(Gallus gallus)
Aves CLK3 35
  • 76.39 (n)
  • 83.98 (a)
CLK3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLK3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clk3 35
  • 72.68 (n)
  • 77.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Doa 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-172 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KNS1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.719 36
  • 50 (a)
OneToMany
Species with no ortholog for CLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CLK3 Gene

ENSEMBL:
Gene Tree for CLK3 (if available)
TreeFam:
Gene Tree for CLK3 (if available)

Paralogs for CLK3 Gene

Paralogs for CLK3 Gene

Pseudogenes.org Pseudogenes for CLK3 Gene

genes like me logo Genes that share paralogs with CLK3: view

Variants for CLK3 Gene

Sequence variations from dbSNP and Humsavar for CLK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1130369 -- 74,627,392(+) AAACC(A/T)GAGAA reference, synonymous-codon, utr-variant-3-prime
rs2068982 -- 74,623,547(-) CATAG(A/G)AACTT intron-variant
rs6495118 -- 74,619,671(+) GAAAG(G/T)TTGCT intron-variant
rs7170823 -- 74,627,818(+) GTGAC(A/T)GACCT intron-variant, downstream-variant-500B
rs8035050 -- 74,614,848(+) ACTGC(A/G)GGTTT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLK3 Gene

Variant ID Type Subtype PubMed ID
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv457204 CNV Loss 19166990
nsv817698 CNV Gain 17921354
esv28499 CNV Gain 19812545
nsv527730 CNV Loss 19592680

Relevant External Links for CLK3 Gene

HapMap Linkage Disequilibrium report
CLK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLK3 Gene

Disorders for CLK3 Gene

No disorders were found for CLK3 Gene.

No data available for UniProtKB/Swiss-Prot for CLK3 Gene

Publications for CLK3 Gene

  1. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PMID: 9637771) Duncan P.I. … Bell J.C. (Exp. Cell Res. 1998) 3 4 23
  2. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PMID: 7990150) Hanes J.J. … Scheit K.H. (J. Mol. Biol. 1994) 2 3 4
  3. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PMID: 9856501) Talmadge C.B. … Rabinow L. (Hum. Genet. 1998) 2 3
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CLK3 Gene

  • Addgene plasmids for CLK3

Sources for CLK3 Gene

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