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CLK3 Gene

protein-coding   GIFtS: 63
GCID: GC15P074900

CDC-Like Kinase 3

  Search for CLK3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC-Like Kinase 31 2 3
EC 2.7.12.13 8
PHCLK32
PHCLK3/1522
Dual Specificity Protein Kinase CLK32

External Ids:    HGNC: 20711   Entrez Gene: 11982   Ensembl: ENSG000001793357   OMIM: 6029905   UniProtKB: P497613   

Export aliases for CLK3 gene to outside databases

Previous GC identifers: GC15U990010 GC15P068014 GC15P072476 GC15P072616 GC15P072687 GC15P051698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLK3 Gene:
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a
nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR)
family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene.
Related pseudogenes are located on chromosomes 1 and 9. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK3 Gene:
CLK3 (CDC-like kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is PRPF4B.

UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the
alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

Gene Wiki entry for CLK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLK3 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK3 promoter sequence
   Search Chromatin IP Primers for CLK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24

CLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P074900:  view genomic region     (about GC identifiers)

Start:
74,890,841 bp from pter      End:
74,932,057 bp from pter
Size:
41,217 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK3  
Size: 638 amino acids; 73515 Da
Sequence caution: Sequence=AAH02555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH19881.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
5 PDB 3D structures from and Proteopedia for CLK3:
2EU9 (3D)        2EXE (3D)        2WU6 (3D)        2WU7 (3D)        3RAW (3D)    
Secondary accessions: D3DW59 Q53Y48 Q9BRS3 Q9BUJ7
Alternative splicing: 4 isoforms:  P49761-4   P49761-1   P49761-2   P49761-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK3: NX_P49761

Explore proteomics data for CLK3 at MOPED

Post-translational modifications: 

  • Autophosphorylates on all three types of residues (By similarity)1
  • Ubiquitination2 at Lys169
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CLK3 (P49761) (see all 11)
     VALKIIRN  MMEKILGP  TRKQKYFY  GFTLFQTH 


    See CLK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123500.1  NP_003983.2  

    ENSEMBL proteins: 
     ENSP00000344112   ENSP00000431825   ENSP00000456399   ENSP00000378505   ENSP00000456278  
     ENSP00000455762   ENSP00000457362   ENSP00000457936   ENSP00000457696   ENSP00000455905  
     ENSP00000458099   ENSP00000456202   ENSP00000454785   ENSP00000454961   ENSP00000456431  
     ENSP00000323106   ENSP00000321136  

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    Search eBioscience for ELISAs for CLK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 3
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49761

    ProtoNet protein and cluster: P49761

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CLK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK3_HUMAN, P49761
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
    SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the
    alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing
    mediated by phosphorylation of SR proteins

         Genatlas biochemistry entry for CLK3:
    CDC-like kinase 3,with two alternatively spliced forms,one catalytically active and one inactive
    isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely
    expressed

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with CLK3           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for CLK3:
     Decreased influenza A virus in  Decreased substrate adherent c  Decreased telomerase activity  G0/1 arrest 
     Gemcitabine induced cell-death  Increased G1 DNA content  Increased apoptosis 

         1 MGI phenotypic allele for Clk3 (no phenotypes)

    Find genes that share phenotypes with CLK3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLK3
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    miRNA
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    miRTarBase miRNAs that target CLK3:
    hsa-mir-7-5p (MIRT025715)

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    Selected qRT-PCR Assays for microRNAs that regulate CLK3 (see all 9):
    hsa-miR-130a* hsa-miR-4297 hsa-miR-23c hsa-miR-218 hsa-miR-23b hsa-miR-1208 hsa-miR-23a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLK3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CLK3 (NM_003992)
    Sino Biological Human cDNA Clone for CLK3
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    Addgene plasmids for CLK3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLK3_HUMAN, P49761: Isoform 1: Nucleus. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle,
    acrosome (By similarity)
    CLK3_HUMAN, P49761: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins
    in the nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with CLK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLK3 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Translational Control
    Translational Control


    Find genes that share SuperPaths with CLK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CLK3
        Translational Control

    1 BioSystems Pathway for CLK3
        mRNA processing



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLK3
    Interactions:

        Search GeneGlobe Interaction Network for CLK3

    Selected Interacting proteins for CLK3 (P497611, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLK2P497601, 3EBI-745579,EBI-750020 I2D: score=5 
    RSRP1Q9BUV02, 3MINT-66690 I2D: score=5 
    YWHAGP619812, 3MINT-50806 I2D: score=4 
    TERF1P542743I2D: score=1 
    TERF2Q155543I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9637771
    GO:0018108peptidyl-tyrosine phosphorylation ----
    GO:0043484regulation of RNA splicing IDA9637771
    GO:0046777protein autophosphorylation IEA--

    Find genes that share ontologies with CLK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLK3

    2 DrugBank Compounds for CLK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLK3 gene (3 alternative transcripts): 
    NM_001130028.1  NM_003992.4  NM_001292.1  

    Unigene Cluster for CLK3:

    CDC-like kinase 3
    Hs.584748  [show with all ESTs]
    Unigene Representative Sequence: CR933693
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000564353(uc002ayf.1) ENST00000567992 ENST00000345005(uc002ayg.4 uc002ayj.4)
    ENST00000483723(uc002ayh.4) ENST00000562389 ENST00000395066(uc010uln.2)
    ENST00000454830(uc010ulm.1 uc002ayk.4) ENST00000569063 ENST00000568139
    ENST00000563297 ENST00000568488 ENST00000568605 ENST00000566126 ENST00000570296
    ENST00000562670 ENST00000564096 ENST00000569406 ENST00000563112
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CLK3 (see all 9):
    hsa-miR-130a* hsa-miR-4297 hsa-miR-23c hsa-miR-218 hsa-miR-23b hsa-miR-1208 hsa-miR-23a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLK3 3' UTR sequence
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    Addgene plasmids for CLK3 
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      QuantiFast Probe-based Assays in human, mouse, rat CLK3

    Additional mRNA sequence: 

    AB209535.1 AK026511.1 AK091692.1 AK225680.1 AK291983.1 AK301689.1 BC002555.2 BC006103.1 
    BC009857.2 BC019881.1 BT006993.1 CR933693.1 L29217.1 

    24 DOTS entries:

    DT.95259401  DT.446374  DT.100038070  DT.91775585  DT.95259405  DT.40115428  DT.100845294  DT.91775594 
    DT.100038071  DT.91989003  DT.91775584  DT.100845297  DT.95259403  DT.95259412  DT.100845303  DT.121044184 
    DT.121044297  DT.121203462  DT.75106585  DT.95130106  DT.95312622  DT.97785184  DT.100791675  DT.97826548 

    Selected AceView cDNA sequences (see all 375):

    BQ684621 AL707833 BC019881 BQ716792 CA315011 BQ183959 CA391781 BU628743 
    AA364944 BU151403 BQ678178 AU136614 BQ025125 BQ051522 BI829282 T58573 
    CA489198 BU957293 AL833165 AI188106 BQ056641 BX503910 BQ054565 BQ648633 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLK3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                -                 -                                                           -                                             
    SP4:                                -                 -     -     -                                               -                                             
    SP5:                                                  -                                                           -                                             

    ExUns: 14a · 14b · 14c ^ 15a · 15b
    SP1:        -     -               
    SP2:        -     -               
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CLK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CLK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATGGA
    CLK3 Expression
    About this image


    CLK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    CLK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584748

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Tissue specificity: Endothelial cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CLK3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk31 , 5 CDC-like kinase 31, 5 86.94(n)1
    88.4(a)1
      9 (31.47 cM)5
    1024141  NM_007713.41  NP_031739.31 
     577507115 
    chicken
    (Gallus gallus)
    Aves CLK31 CDC-like kinase 3 76.39(n)
    83.98(a)
      415295  NM_001012524.2  NP_001012542.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLK36
    CDC-like kinase 3
    87(a)
    1 ↔ 1
    GL343721.1(146799-161035)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clk31 CDC-like kinase 3 72.68(n)
    77.46(a)
      496952  NM_001011462.1  NP_001011462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa6
    Darkener of apricot
    13(a)
    1 → many
    3R(24713799-24748494)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform a (tag-172) mRNA, complet...
    25(a)
    1 → many
    X(14284868-14293993) WBGene00006517
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    21(a)
    1 → many
    XII(105686-107899) YLL019C


    ENSEMBL Gene Tree for CLK3 (if available)
    TreeFam Gene Tree for CLK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLK3 gene
    PRPF4B2  CLK12  CLK42  CLK22  
    5 SIMAP similar genes for CLK3 using alignment to 15 protein entries:     CLK3_HUMAN (see all proteins):
    LOC402468    CLK2    CLK1    CLK4    DYRK4

    Find genes that share paralogs with CLK3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CLK3
    PGOHUM00000259538 PGOHUM00000235982


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLK3 (see all 408)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162813591,2
    C,F--74898767(+) TCCTGG/CGTTGG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs752688231,2
    C,F--74898806(+) AATGGC/ACTGGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1830454641,2
    --74899090(+) AACAAA/GCAAAA 1 -- us2k10--------
    rs1887619011,2
    C--74899091(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs116332081,2
    C,F,H--74899095(+) ACAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.33WA NA CSA 6
    rs608392241,2
    C--74899130(+) TTTTC-/CTCTGTA 1 -- us2k10--------
    rs1869633011,2
    --74899278(+) TTTTCC/TTTCCA 1 -- us2k10--------
    rs1454510631,2
    C--74899286(+) CCATCA/GAGATC 1 -- us2k10--------
    rs1915505231,2
    --74899431(+) TCTGGA/GGGTGT 1 -- us2k10--------
    rs64951171,2
    C,F,A,H--74899500(+) GTCTGT/CCCATG 1 -- us2k123Minor allele frequency- C:0.36EA NA NS CSA WA 2550

    HapMap Linkage Disequilibrium report for CLK3 (74890841 - 74932057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv527730CNV Loss19592680
    nsv904379CNV Loss21882294
    nsv457204CNV Loss19166990
    esv28499CNV Gain19812545
    nsv817698CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLK3
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602990    OMIM disorders: --


    Find genes that share disorders with CLK3           About GenesLikeMe


    Export disorders for CLK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLK3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CLK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3 Hanes J.J.... Scheit K.H. (J. Mol. Biol. 1994)
    2. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2, 9 Duncan P.I.... Bell J.C. (Exp. Cell Res. 1998)
    3. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A.... Rauch U. (Circ. Res. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (Hum. Genet. 1998)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1198 HGNC: 2071 AceView: CLK3 Ensembl:ENSG00000179335 euGenes: HUgn1198
    ECgene: CLK3 H-InvDB: CLK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLK3 gene:
    Search GeneIP for patents involving CLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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