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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK3 Gene

protein-coding   GIFtS: 59
GCID: GC15P074900

CDC-like kinase 3
 Explore 2 diseases affiliated with
CLK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLK3    

Aliases
for CLK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CDC-Like Kinase 31 2 3
EC 2.7.12.13 8
Clk31
PHCLK32
PHCLK3/1522
Dual Specificity Protein Kinase CLK32

External Ids:    HGNC: 20711   Entrez Gene: 11982   Ensembl: ENSG000001793357   OMIM: 6029905   UniProtKB: P497613   

Export aliases for CLK3 gene to outside databases

Previous GC identifers: GC15U990010 GC15P068014 GC15P072476 GC15P072616 GC15P072687 GC15P051698


Summaries
for CLK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLK3:
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear
dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of
splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related
pseudogenes are located on chromosomes 1 and 9. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory
mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles
to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue
factor (F3) pre-mRNA in endothelial cells

Gene Wiki entry for CLK3


Genomic Views
for CLK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK3 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24

CLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P074900:  view genomic region     (about GC identifiers)

Start:
 74,890,841 bp from pter      End:
 74,932,057 bp from pter
Size:
 41,217 bases      Orientation:
 plus strand

Proteins
for CLK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK3  
Size: 638 amino acids; 73515 Da
Subcellular location: Isoform 1: Nucleus. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome
(By similarity)
Subcellular location: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the
nuclear speckles
Sequence caution: Sequence=AAH02555.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH19881.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
5 PDB 3D structures from and Proteopedia for CLK3:
2EU9 (3D)        2EXE (3D)        2WU6 (3D)        2WU7 (3D)        3RAW (3D)    
Secondary accessions: D3DW59 Q53Y48 Q9BRS3 Q9BUJ7
Alternative splicing: 4 isoforms:  P49761-4   P49761-1   P49761-2   P49761-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK3: NX_P49761

Post-translational modifications:

  • Autophosphorylates on all three types of residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49761

    • 4/11 DME Specific Peptides for CLK3 (P49761) (see all 11)
     VALKIIRN  MMEKILGP  TRKQKYFY  GFTLFQTH 

    CLK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123500.1  NP_003983.2  

    ENSEMBL proteins: 
     ENSP00000344112   ENSP00000431825   ENSP00000456399   ENSP00000378505   ENSP00000456278  
     ENSP00000455762   ENSP00000457362   ENSP00000457936   ENSP00000457696   ENSP00000455905  
     ENSP00000458099   ENSP00000456202   ENSP00000454785   ENSP00000454961   ENSP00000456431  
     ENSP00000323106   ENSP00000321136  

    Human Recombinant Protein Products: 
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    Novus Biologicals CLK3 Lysate
    Sino Biological Recombinant Protein for CLK3
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLK3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0045111intermediate filament cytoskeleton IDA--


    CLK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLK3

    Protein Domains /
    Families
    for CLK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49761

    ProtoNet protein and cluster: P49761

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CLK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
    serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory
    mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles
    to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue
    factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing
    mediated by phosphorylation of SR proteins

         Genatlas biochemistry entry for CLK3:
    CDC-like kinase 3,with two alternatively spliced forms,one catalytically active and one inactive isoforms,interacting
    with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely expressed

    Enzyme Number (IUBMB): EC 2.7.12.11 2

    miRNA
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    hsa-miR-130a* hsa-miR-4297 hsa-miR-23c hsa-miR-218 hsa-miR-23b hsa-miR-1208 hsa-miR-23a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--


    CLK3 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for CLK3:
     Decreased influenza A virus in  Decreased substrate adherent c  Decreased telomerase activity  G0/1 arrest 
     Gemcitabine induced cell-death  Increased G1 DNA content  Increased apoptosis 

    Animal Models:
         1 MGI phenotypic allele for Clk3 (no phenotypes)

    CLK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translational Control
    		Translational Control1.00
    2mRNA Splicing - Major Pathway
    		mRNA processing0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CLK3
        Translational Control

    1 BioSystems Pathway for CLK3 
        mRNA processing



    CLK3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLK3

    5/6 Interacting proteins for CLK3 (P497612, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1orf63Q9BUV02, 3MINT-66690 I2D: score=5 
    YWHAGP619812, 3MINT-50806 I2D: score=4 
    CLK2P497603I2D: score=5 
    TERF1P542743I2D: score=1 
    TERF2Q155543I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9637771
    GO:0016310phosphorylation ----
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0043484regulation of RNA splicing IDA9637771
    GO:0046777protein autophosphorylation IEA--


    CLK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK3

    2 DrugBank Compounds for CLK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CLK3 

    Transcripts
    for CLK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLK3 gene (3 alternative transcripts): 
    NM_001130028.1  NM_003992.4  NM_001292.1  

    Unigene Cluster for CLK3:

    CDC-like kinase 3
    Hs.584748  [show with all ESTs]
    Unigene Representative Sequence: CR933693
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000564353(uc002ayf.1) ENST00000567992 ENST00000345005(uc002ayg.4 uc002ayj.4)
    ENST00000483723(uc002ayh.4) ENST00000562389 ENST00000395066(uc010uln.2)
    ENST00000454830(uc010ulm.1 uc002ayk.4) ENST00000569063 ENST00000568139
    ENST00000563297 ENST00000568488 ENST00000568605 ENST00000566126 ENST00000570296
    ENST00000562670 ENST00000564096 ENST00000569406 ENST00000563112

    miRNA
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    hsa-miR-130a* hsa-miR-4297 hsa-miR-23c hsa-miR-218 hsa-miR-23b hsa-miR-1208 hsa-miR-23a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209535.1 AK026511.1 AK091692.1 AK225680.1 AK291983.1 AK301689.1 BC002555.2 BC006103.1 
    BC009857.2 BC019881.1 BT006993.1 CR933693.1 L29217.1 

    24/26 DOTS entries (see all 26):

    DT.95259401  DT.446374  DT.100038070  DT.91775585  DT.95259405  DT.40115428  DT.100845294  DT.91775594 
    DT.100038071  DT.91989003  DT.91775584  DT.100845297  DT.414479  DT.95259403  DT.95259412  DT.100845303 
    DT.100791674  DT.121044184  DT.121044297  DT.121203462  DT.75106585  DT.95130106  DT.95312622  DT.97785184 

    24/375 AceView cDNA sequences (see all 375):

    AI355332 BC009857 AW849469 BX280944 BQ648633 BX431071 CD743118 BX503910 
    AI268748 AW451521 AK096115 AI188106 BU557990 CA427931 BQ056641 BM809493 
    AL833165 AK122860 BG259636 AI342362 AW849274 BG575027 AK097982 BX646144 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CLK3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^
    SP1:                                                                                                              -                                             
    SP2:                                                                                                                                                            
    SP3:                                -                 -                                                           -                                             
    SP4:                                -                 -     -     -                                               -                                             
    SP5:                                                  -                                                           -                                             

    ExUns: 14a · 14b · 14c ^ 15a · 15b
    SP1:        -     -               
    SP2:        -     -               
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CLK3

    Expression
    for CLK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGAGATGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK3

    SOURCE GeneReport for Unigene cluster: Hs.584748

    UniProtKB/Swiss-Prot: CLK3_HUMAN, P49761
    Tissue specificity: Endothelial cells

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    In Situ
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    Orthologs
    for CLK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK3 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLK31 CDC-like kinase 3 78.58(n)
    86.24(a)    		   415295  NM_001012524.2  NP_001012542.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CLK36
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343721.1(145613-156492)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Doa6
    		 Darkener of apricot
    		 12(a)
    		 1 → many
    		 3R(24713799-24748494)
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1726
    		 Temporarily Assigned Gene name family member (tag-...
    		 22(a)
    		 1 → many
    		 X(14284798-14293923)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AME36
    AFC26
    (see all 3)    		 serine/threonine-protein kinase AFC2
    (see all 3)    		 40(a)
    36(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(15756128-15759314)
    4(12754529-12757786)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 serine/threonine-protein kinase AFC3, putative, ex...
    serine/threonine-protein kinase AFC2, putative, ex...
    (see all 3)    		 39(a)
    37(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 1(23089710-23094339)
    12(16193413-16196784)


    ENSEMBL Gene Tree for CLK3 (if available)
    TreeFam Gene Tree for CLK3 (if available) 

    Paralogs
    for CLK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK3 gene
    PRPF4B2  CLK12  CLK42  CLK22  
    6 SIMAP similar genes for CLK3 using alignment to 15 protein entries:     CLK3_HUMAN (see all proteins):
    LOC402468    CLK2    CLK1    CLK4    DYRK4    SRPK3

    CLK3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CLK3
    PGOHUM00000259538 PGOHUM00000235982


    Genomic Variants
    for CLK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 NCBI SNPs in CLK3 are shown (see all 327)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1162813591,2
    		C,F,--74898767(+) TCCTGG/CGTTGG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs752688231,2
    		C,--74898806(+) AATGGC/ACTGGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1830454641,2
    		--74899090(+) AACAAA/GCAAAA 1 -- us2k10--------
    rs1887619011,2
    		C--74899091(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs116332081,2
    		C,F,H,--74899095(+) ACAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.33WA NA CSA 6
    rs608392241,2
    		C,--74899130(+) TTTTC-/CTCTGTA 1 -- us2k10--------
    rs1869633011,2
    		--74899278(+) TTTTCC/TTTCCA 1 -- us2k10--------
    rs1454510631,2
    		--74899286(+) CCATCA/GAGATC 1 -- us2k10--------
    rs1915505231,2
    		--74899431(+) TCTGGA/GGGTGT 1 -- us2k10--------
    rs64951171,2
    		C,F,A,H,--74899500(+) GTCTGT/CCCATG 1 -- us2k123Minor allele frequency- C:0.36EA NA NS CSA WA 2550

    HapMap Linkage Disequilibrium report for CLK3 (74890841 - 74932057 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CLK3
         2 CNVs: 9749 72286
         1 Inversion: 37170

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    Disorders / Diseases
    for CLK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLK3 for disorders           About GeneDecksing

    OMIM gene information: 602990    OMIM disorders: --

    2 diseases for CLK3:    About MalaCards
    dna topoisomerase i    malaria


    Export disorders for CLK3 gene to outside databases

    Publications
    for CLK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CLK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3 Hanes J.J.... Scheit K.H. (1994)
    2. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2, 9 Duncan P.I.... Bell J.C. (1998)
    3. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    7. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (1998)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre- RNA splicing. (PubMed id 21615147)2 Debdab M....Bazureau J.P. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for CLK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1198 HGNC: 2071 AceView: CLK3 Ensembl:ENSG00000179335 euGenes: HUgn1198
    ECgene: CLK3 H-InvDB: CLK3

    Other Databases showing CLK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CLK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLK3 gene:
    Search GeneIP for patents involving CLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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