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CLK2 Gene

protein-coding   GIFtS: 61
GCID: GC01M155232

CDC-Like Kinase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CDC-Like Kinase 21 2 3
EC 2.7.12.13 8
CLK Kinase2
Dual Specificity Protein Kinase CLK22
hCLK22

External Ids:    HGNC: 20691   Entrez Gene: 11962   Ensembl: ENSG000001764447   OMIM: 6029895   UniProtKB: P497603   

Export aliases for CLK2 gene to outside databases

Previous GC identifers: GC01M153090 GC01M150973 GC01M152010 GC01M152449 GC01M152045 GC01M153499 GC01M126594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLK2 Gene:
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been
shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex,
which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this
gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this
gene, but encodes a protein that is involved in telomere length regulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK2 Gene:
CLK2 (CDC-like kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic
gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its
phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the
PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the
alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

Gene Wiki entry for CLK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLK2 gene promoter:
         AhR   MAZR   POU2F1   p53   POU2F1a   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK2 promoter sequence
   Search Chromatin IP Primers for CLK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

CLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155232:  view genomic region     (about GC identifiers)

Start:
155,232,659 bp from pter      End:
155,248,282 bp from pter
Size:
15,624 bases      Orientation:
minus strand

1 alternative location:
Chr1-,NW_003315906 67,891-78,513     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK2  
Size: 499 amino acids; 60090 Da
Subunit: Interacts with RBMX. Interacts with AKT1 and UBL5
1 PDB 3D structure from and Proteopedia for CLK2:
3NR9 (3D)    
Secondary accessions: B1AVS9 B5MBX6 Q96CQ0
Alternative splicing: 3 isoforms:  P49760-1   P49760-2   P49760-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK2: NX_P49760

Explore proteomics data for CLK2 at MOPED

Post-translational modifications: 

  • Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by
    ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose
    radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces
    its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its
    subnuclear localization; inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CLK2 (P49760) (see all 9)
     LFQTHDN  TRKQKYFY  GFTLFQTH  EHLAMMER 


    See CLK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003984.2  
    ENSEMBL proteins: 
     ENSP00000354856   ENSP00000357345   ENSP00000347759   ENSP00000441023  

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    Cloud-Clone Corp. Proteins for CLK2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 2
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49760

    ProtoNet protein and cluster: P49760

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CLK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK2_HUMAN, P49760
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
    SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic
    gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its
    phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the
    PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the
    alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: 5,6-dichloro-1-b-D-ribofuranosylbenzimidazole (DRB) inhibits autophosphorylation. TG003
    inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR
    proteins (By similarity)

         Genatlas biochemistry entry for CLK2:
    CDC-like kinase 2,with two alternatively spliced forms,one catalytically active and one inactive
    isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely
    expressed

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10480872
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with CLK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Clk2 (no phenotypes)

    Find genes that share phenotypes with CLK2           About GenesLikeMe

    Animal Models:
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    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCLK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLK2_HUMAN, P49760: Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results
    in accumulation in the nuclear speckle (By similarity)
    CLK2_HUMAN, P49760: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins
    in the nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with CLK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLK2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44


    1 BioSystems Pathway for CLK2
        mRNA processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLK2
    Interactions:

        GeneGlobe Interaction Network for CLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLK2 (P497601, 2, 3 ENSP000003548564) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50805 I2D: score=4 STRING: ENSP00000306330
    CLK3P497611, 3EBI-750020,EBI-745579 I2D: score=5 
    PTPN1P180312, 3, ENSP000003606834MINT-6797067 I2D: score=4 STRING: ENSP00000360683
    TOPBP1Q925473, ENSP000002608104I2D: score=1 STRING: ENSP00000260810
    FANCMQ8IYD83, ENSP000002674304I2D: score=1 STRING: ENSP00000267430
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA--
    GO:0010033response to organic substance ----
    GO:0010212response to ionizing radiation IMP--
    GO:0018108peptidyl-tyrosine phosphorylation ----
    GO:0032526response to retinoic acid IEA--

    Find genes that share ontologies with CLK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLK2

    2 HMDB Compounds for CLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLK2 gene (2 alternative transcripts): 
    NM_003993.2  NM_001291.2  

    Unigene Cluster for CLK2:

    CDC-like kinase 2
    Hs.73986  [show with all ESTs]
    Unigene Representative Sequence: AK091036
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361168 ENST00000368361(uc001fjw.3 uc001fjy.3 uc001fjx.3 uc009wqm.3)
    ENST00000476983 ENST00000355560 ENST00000497188 ENST00000471047 ENST00000484699
    ENST00000536801
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CLK2:
    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCLK2 3' UTR sequence
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    Additional mRNA sequence: 

    AK091036.1 AK291995.1 AK303696.1 BC006274.2 BC014067.2 BC053603.1 L29216.1 L29218.1 

    15 DOTS entries:

    DT.314746  DT.95155137  DT.91775599  DT.100058931  DT.95262254  DT.121427755  DT.92033405  DT.441421 
    DT.100035132  DT.100021589  DT.100675800  DT.121427728  DT.95314406  DT.101975537  DT.97768072 

    Selected AceView cDNA sequences (see all 369):

    BU633715 BG286233 BU634153 BE743729 BG254314 CA440266 BC007444 BM928730 
    AW170535 NM_198264 AL353941 BX095192 BU844369 CR623321 CD724153 BE514752 
    BU845275 BM987374 AX746743 BQ012591 AI222824 BC053603 BC006493 BM971663 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLK2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                      -                       -     -                 -                             -     -                                 
    SP2:                                      -                       -     -                 -                             -     -                                 
    SP3:                                      -                       -     -     -     -     -                             -     -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                      -                       -     -                 -                                                                     

    ExUns: 13 ^ 14 ^ 15a · 15b
    SP1:        -               
    SP2:        -               
    SP3:        -               
    SP4:        -               
    SP5:                        


    ECgene alternative splicing isoforms for CLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATAAGG
    CLK2 Expression
    About this image


    CLK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
    CLK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73986

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Tissue specificity: Endothelial cells

        Custom PCR Arrays for CLK2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk21 , 5 CDC-like kinase 21, 5 92.57(n)1
    96.99(a)1
      3 (39.01 cM)5
    127481  NM_007712.31  NP_031738.21 
     891647955 
    chicken
    (Gallus gallus)
    Aves CLK21 CDC-like kinase 2 75.35(n)
    85.05(a)
      425060  NM_001031326.1  NP_001026497.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLK26
    CDC-like kinase 2
    80(a)
    1 ↔ 1
    GL343519.1(550162-567209)
    African clawed frog
    (Xenopus laevis)
    Amphibia clk2-prov2 CDC-like kinase 2 78.02(n)    BC043963.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb20c022 Danio rerio cDNA clone IMAGE5604666, partial cds 71.47(n)    BC057521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa1 Darkener of apricot 64.71(n)
    73.02(a)
      43415  NM_176581.4  NP_788758.3 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1721 tag-172 58.81(n)
    63.58(a)
      3565068  NM_171798.1  NP_741927.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    21(a)
    1 → many
    XII(105686-107899) YLL019C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FC21 FC2 54.34(n)
    50.89(a)
      828576  NM_118607.2  NP_194205.1 
    rice
    (Oryza sativa)
    Liliopsida Os.357122 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.81(n)    AK066167.1 


    ENSEMBL Gene Tree for CLK2 (if available)
    TreeFam Gene Tree for CLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLK2 gene
    CLK32  PRPF4B2  CLK12  CLK42  
    6 SIMAP similar genes for CLK2 using alignment to 5 protein entries:     CLK2_HUMAN (see all proteins):
    LOC402468    CLK1    CLK3    CLK4    DYRK4    PRPF4B

    Find genes that share paralogs with CLK2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CLK2
    PGOHUM00000232616


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CLK2 (see all 265)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463267361,2
    --155234217(+) CAGGTA/GGAAGA 1 -- int10--------
    rs561278101,2
    C--155234253(+) CCATCA/GCTTAC 1 -- int10--------
    rs1995681731,2
    --155234256(+) TCACTA/TACCTG 1 -- int10--------
    rs1921602921,2
    C--155234589(+) GAGGAC/TGAACC 1 -- int10--------
    rs1443124591,2
    C--155234617(+) ATTCCA/TCCAGT 1 -- int10--------
    rs1453197451,2
    --155234686(+) CAAGCC/TCTGGG 1 -- int10--------
    rs10765561,2
    C,F,O,A,H--155234821(+) GTGCCA/GGATAT 1 -- int133Minor allele frequency- T:0.00NA EA NS WA CSA 2868
    rs1997755451,2
    --155234828(+) ATATA-/TAGT  
            
    TATTC
    1 -- int10--------
    rs1487720141,2
    C--155234914(+) AAAATA/GTAACA 1 -- int10--------
    rs1424373321,2
    --155234975(+) AAGGAA/GGGAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLK2 (155232659 - 155248282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CLK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv90CNV Insertion15895083
    nsv436027CNV Insertion17901297
    nsv3010CNV Insertion18451855
    dgv3n68CNV Loss17160897
    nsv831636CNV Loss17160897
    nsv872457CNV Loss21882294
    esv33869CNV Loss17666407
    esv23319CNV Gain19812545
    dgv132e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CLK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602989    OMIM disorders: --


    Find genes that share disorders with CLK2           About GenesLikeMe


    Export disorders for CLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLK2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3, 9 Hanes J.J.... Scheit K.H. (J. Mol. Biol. 1994)
    2. Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. (PubMed id 20682768)1, 2 Nam S.Y.... Jin Y.W. (J. Biol. Chem. 2010)
    3. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PubMed id 19282290)1, 2 Heinrich B.... Stamm S. (J. Biol. Chem. 2009)
    4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A.... Rauch U. (Circ. Res. 2009)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (Biochem. Biophys. Res. Commun. 2003)
    8. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PubMed id 10480872)1, 2 Moeslein F.M.... Landreth G.E. (J. Biol. Chem. 1999)
    9. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (Hum. Genet. 1998)
    10. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2 Duncan P.I.... Bell J.C. (Exp. Cell Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1196 HGNC: 2069 AceView: CLK2andC1orf2 Ensembl:ENSG00000176444 euGenes: HUgn1196
    ECgene: CLK2 H-InvDB: CLK2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLK2 gene:
    Search GeneIP for patents involving CLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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