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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK2 Gene

protein-coding   GIFtS: 62
GCID: GC01M155232

CDC-Like Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CDC-Like Kinase 21 2 3
EC 2.7.12.13 8
CLK Kinase2
Dual Specificity Protein Kinase CLK22
hCLK22

External Ids:    HGNC: 20691   Entrez Gene: 11962   Ensembl: ENSG000001764447   OMIM: 6029895   UniProtKB: P497603   

Export aliases for CLK2 gene to outside databases

Previous GC identifers: GC01M153090 GC01M150973 GC01M152010 GC01M152449 GC01M152045 GC01M153499 GC01M126594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLK2 Gene:
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been
shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex,
which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this
gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this
gene, but encodes a protein that is involved in telomere length regulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLK2 Gene: 
CLK2 (CDC-like kinase 2) is a protein-coding gene. Diseases associated with CLK2 include gaucher's disease, and corneal dystrophy, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic
gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its
phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the
PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the
alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

Gene Wiki entry for CLK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK2 gene promoter:
         AhR   MAZR   POU2F1   p53   POU2F1a   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

CLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155232:  view genomic region     (about GC identifiers)

Start:
155,232,659 bp from pter      End:
155,248,282 bp from pter
Size:
15,624 bases      Orientation:
minus strand

1 alternative location:
Chr1-,NW_003315906 67,891-78,513     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK2  
Size: 499 amino acids; 60090 Da
Subunit: Interacts with RBMX. Interacts with AKT1 and UBL5
Subcellular location: Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results
in accumulation in the nuclear speckle (By similarity)
Subcellular location: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins
in the nuclear speckles
1 PDB 3D structure from and Proteopedia for CLK2:
3NR9 (3D)    
Secondary accessions: B1AVS9 B5MBX6 Q96CQ0
Alternative splicing: 3 isoforms:  P49760-1   P49760-2   P49760-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK2: NX_P49760

Explore proteomics data for CLK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by
    ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose
    radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces
    its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its
    subnuclear localization; inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49760

  • 4/9 DME Specific Peptides for CLK2 (P49760) (see all 9)
     LFQTHDN  TRKQKYFY  GFTLFQTH  EHLAMMER 

    CLK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLK2 Protein Expression
    REFSEQ proteins: NP_003984.2  
    ENSEMBL proteins: 
     ENSP00000354856   ENSP00000357345   ENSP00000347759   ENSP00000441023  

    Human Recombinant Protein Products for CLK2: 
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    Novus Biologicals CLK2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLK2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9637771
    GO:0016607nuclear speck IEA--

    CLK2 for ontologies           About GeneDecksing



    CLK2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CLK2 
    Cloud-Clone Corp. CLIAs for CLK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 2 
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49760

    ProtoNet protein and cluster: P49760

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    CLK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK2_HUMAN, P49760
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of
    SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic
    gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its
    phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the
    PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the
    alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: 5,6-dichloro-1-b-D-ribofuranosylbenzimidazole (DRB) inhibits autophosphorylation. TG003
    inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR
    proteins (By similarity)

         Genatlas biochemistry entry for CLK2:
    CDC-like kinase 2,with two alternatively spliced forms,one catalytically active and one inactive
    isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely
    expressed

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10480872
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI16189514
         
    CLK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CLK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Clk2 (no phenotypes)

    CLK2 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLK2 
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    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCLK2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46


    1 BioSystems Pathway for CLK2
        mRNA processing


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CLK2 (P497601, 2, 3 ENSP000003548564) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50805 I2D: score=4 STRING: ENSP00000306330
    PTPN1P180312, 3, ENSP000003606834MINT-6797067 I2D: score=4 STRING: ENSP00000360683
    TOPBP1Q925473, ENSP000002608104I2D: score=1 STRING: ENSP00000260810
    FANCMQ8IYD83, ENSP000002674304I2D: score=1 STRING: ENSP00000267430
    ATRQ135353, ENSP000003437414I2D: score=1 STRING: ENSP00000343741
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA--
    GO:0010212response to ionizing radiation IMP--
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0032526response to retinoic acid IEA--
    GO:0042221response to chemical stimulus ----

    CLK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK2

    2 HMDB Compounds for CLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CLK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLK2 gene (2 alternative transcripts): 
    NM_003993.2  NM_001291.2  

    Unigene Cluster for CLK2:

    CDC-like kinase 2
    Hs.73986  [show with all ESTs]
    Unigene Representative Sequence: AK091036
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361168 ENST00000368361(uc001fjw.3 uc001fjy.3 uc001fjx.3 uc009wqm.3)
    ENST00000476983 ENST00000355560 ENST00000497188 ENST00000471047 ENST00000484699
    ENST00000536801
    miRNA
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    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCLK2 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLK2

    Additional mRNA sequence: 

    AK091036.1 AK291995.1 AK303696.1 BC006274.2 BC014067.2 BC053603.1 L29216.1 L29218.1 

    15 DOTS entries:

    DT.314746  DT.95155137  DT.91775599  DT.100058931  DT.95262254  DT.121427755  DT.92033405  DT.441421 
    DT.100035132  DT.100021589  DT.100675800  DT.121427728  DT.95314406  DT.101975537  DT.97768072 

    24/369 AceView cDNA sequences (see all 369):

    BM555300 BU542031 BM826338 BC006493 AI222824 BQ719474 BU189990 AI379352 
    BM971663 BQ067887 AW004948 NM_198264 BX350507 CK431118 BM763530 BI768617 
    AI590273 BM987374 CB850653 BC040136 CR607925 AU118727 BQ643361 CR623321 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CLK2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                      -                       -     -                 -                             -     -                                 
    SP2:                                      -                       -     -                 -                             -     -                                 
    SP3:                                      -                       -     -     -     -     -                             -     -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                      -                       -     -                 -                                                                     

    ExUns: 13 ^ 14 ^ 15a · 15b
    SP1:        -               
    SP2:        -               
    SP3:        -               
    SP4:        -               
    SP5:                        


    ECgene alternative splicing isoforms for CLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK2 expression in normal human tissues (normalized intensities)      CLK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATAAGG
    CLK2 Expression
    About this image


    CLK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Ovary (Reproductive System)
             oocyte   

    See CLK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK2

    SOURCE GeneReport for Unigene cluster: Hs.73986

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Tissue specificity: Endothelial cells

        SABiosciences Custom PCR Arrays for CLK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK2 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk21 , 5 CDC-like kinase 21, 5 92.57(n)1
    96.99(a)1
      3 (39.01 cM)5
    127481  NM_007712.31  NP_031738.21 
     891647955 
    chicken
    (Gallus gallus)
    Aves CLK21 CDC-like kinase 2 78.45(n)
    89.49(a)
      425060  NM_001031326.1  NP_001026497.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLK26
    CDC-like kinase 2
    80(a)
    1 ↔ 1
    GL343519.1(550162-567209)
    African clawed frog
    (Xenopus laevis)
    Amphibia clk2-prov2 CDC-like kinase 2 78.02(n)    BC043963.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb20c022 Danio rerio cDNA clone IMAGE5604666, partial cds 71.47(n)    BC057521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa1 Darkener of apricot 58.3(n)
    61.66(a)
      43415  NM_176581.4  NP_788758.3 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform b
    25(a)
    1 → many
    X(14284868-14293993)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    20(a)
    1 → many
    XII(105686-107899)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FC21 serine/threonine-protein kinase AFC2 54.34(n)
    50.89(a)
      828576  NM_118607.2  NP_194205.1 
    rice
    (Oryza sativa)
    Liliopsida Os.357122 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.81(n)    AK066167.1 


    ENSEMBL Gene Tree for CLK2 (if available)
    TreeFam Gene Tree for CLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK2 gene
    CLK32  PRPF4B2  CLK12  CLK42  
    6 SIMAP similar genes for CLK2 using alignment to 5 protein entries:     CLK2_HUMAN (see all proteins):
    LOC402468    CLK1    CLK3    CLK4    DYRK4    PRPF4B

    CLK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLK2
    PGOHUM00000232616


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 SNPs in CLK2 are shown (see all 265)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463267361,2
    --155234217(+) CAGGTA/GGAAGA 1 -- int10--------
    rs561278101,2
    C--155234253(+) CCATCA/GCTTAC 1 -- int10--------
    rs1995681731,2
    --155234256(+) TCACTA/TACCTG 1 -- int10--------
    rs1921602921,2
    C--155234589(+) GAGGAC/TGAACC 1 -- int10--------
    rs1443124591,2
    C--155234617(+) ATTCCA/TCCAGT 1 -- int10--------
    rs1453197451,2
    --155234686(+) CAAGCC/TCTGGG 1 -- int10--------
    rs10765561,2
    C,F,O,A,H--155234821(+) GTGCCA/GGATAT 1 -- int133Minor allele frequency- T:0.00NA EA NS WA CSA 2868
    rs1997755451,2
    --155234828(+) ATATA-/TAGT  
            
    TATTC
    1 -- int10--------
    rs1487720141,2
    C--155234914(+) AAAATA/GTAACA 1 -- int10--------
    rs1424373321,2
    --155234975(+) AAGGAA/GGGAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLK2 (155232659 - 155248282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CLK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv90CNV Insertion15895083
    nsv436027CNV Insertion17901297
    nsv3010CNV Insertion18451855
    dgv3n68CNV Loss17160897
    nsv831636CNV Loss17160897
    nsv872457CNV Loss21882294
    esv33869CNV Loss17666407
    esv23319CNV Gain19812545
    dgv132e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CLK2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602989    OMIM disorders: --

    8 diseases for CLK2:    About MalaCards
    gaucher's disease    corneal dystrophy    fanconi's anemia    anemia
    ataxia    mental retardation    endotheliitis    hepatitis


    CLK2 for disorders           About GeneDecksing


    Export disorders for CLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3, 9 Hanes J.J.... Scheit K.H. (1994)
    2. Phosphorylation of CLK2 at serine 34 and threonine 12 7 by AKT controls cell survival after ionizing radiation. (PubMed id 20682768)1, 2 Nam S.Y....Jin Y.W. (2010)
    3. Heterogeneous Nuclear Ribonucleoprotein G Regulates Splice Site Selection by Binding to CC(A/C)-rich Regions in Pre-mRNA. (PubMed id 19282290)1, 2 Heinrich B....Stamm S. (2009)
    4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (2003)
    8. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PubMed id 10480872)1, 2 Moeslein F.M....Landreth G.E. (1999)
    9. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (1998)
    10. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2 Duncan P.I.... Bell J.C. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1196 HGNC: 2069 AceView: CLK2andC1orf2 Ensembl:ENSG00000176444 euGenes: HUgn1196
    ECgene: CLK2 H-InvDB: CLK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLK2 gene:
    Search GeneIP for patents involving CLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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