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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK2 Gene

protein-coding   GIFtS: 60
GCID: GC01M155232

CDC-like kinase 2
 Explore 8 diseases affiliated with
CLK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLK2    

Aliases
for CLK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CDC-Like Kinase 21 2 3
EC 2.7.12.13 8
Clk21
CLK Kinase2
Dual Specificity Protein Kinase CLK22
HCLK21

External Ids:    HGNC: 20691   Entrez Gene: 11962   Ensembl: ENSG000001764447   OMIM: 6029895   UniProtKB: P497603   

Export aliases for CLK2 gene to outside databases

Previous GC identifers: GC01M153090 GC01M150973 GC01M152010 GC01M152449 GC01M152045 GC01M153499 GC01M126594


Summaries
for CLK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLK2:
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to
interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part
of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from
TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein
that is involved in telomere length regulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory
mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles
to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by
repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B
thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of
AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in
endothelial cells

Gene Wiki entry for CLK2


Genomic Views
for CLK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK2 gene promoter:
         AhR   MAZR   POU2F1   p53   POU2F1a   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

CLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155232:  view genomic region     (about GC identifiers)

Start:
 155,232,659 bp from pter      End:
 155,248,282 bp from pter
Size:
 15,624 bases      Orientation:
 minus strand

1 alternative location:
Chr1-,PATCHES 155,248,049-155,258,671     

Proteins
for CLK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK2  
Size: 499 amino acids; 60090 Da
Subunit: Interacts with RBMX. Interacts with AKT1 and UBL5
Subcellular location: Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in
accumulation in the nuclear speckle (By similarity)
Subcellular location: Isoform 2: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the
nuclear speckles
1 PDB 3D structure from and Proteopedia for CLK2:
3NR9 (3D)    
Secondary accessions: B1AVS9 B5MBX6 Q96CQ0
Alternative splicing: 3 isoforms:  P49760-1   P49760-2   P49760-3   (Lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CLK2: NX_P49760

Post-translational modifications:

  • Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by ionizing
    • radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose radiation and
    prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces its kinase activity
    which is required for its stability. The phosphorylation status at Ser-142 influences its subnuclear localization;
    inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49760

    • 4/9 DME Specific Peptides for CLK2 (P49760) (see all 9)
     LFQTHDN  TRKQKYFY  GFTLFQTH  EHLAMMER 

    CLK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003984.2  
    ENSEMBL proteins: 
     ENSP00000354856   ENSP00000357345   ENSP00000347759   ENSP00000441023  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CLK2
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    Novus Biologicals CLK2 Proteins
    Novus Biologicals CLK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLK2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9637771
    GO:0016607nuclear speck IEA--


    CLK2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLK2

    Protein Domains /
    Families
    for CLK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49760

    ProtoNet protein and cluster: P49760

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CLK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
    serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory
    mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles
    to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by
    repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B
    thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of
    AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in
    endothelial cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: 5,6-dichloro-1-b-D-ribofuranosylbenzimidazole (DRB) inhibits autophosphorylation. TG003 inhibits its
    kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By
    similarity)

         Genatlas biochemistry entry for CLK2:
    CDC-like kinase 2,with two alternatively spliced forms,one catalytically active and one inactive isoforms,interacting
    with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely expressed

    Enzyme Number (IUBMB): EC 2.7.12.11 2

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK2:
    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: CLK2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK2 (see all 7)
    OriGene shRNA RFP: CLK2
    OriGene siRNA: CLK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK2

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CLK2

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA10480872
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    CLK2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CLK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Clk2 (no phenotypes)

    CLK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA processing0.48


    1 BioSystems Pathway for CLK2 
        mRNA processing


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CLK2 (P497601, 2, 3 ENSP000003548564) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50805 I2D: score=4 STRING: ENSP00000306330
    PTPN1P180312, 3, ENSP000003606834MINT-6797067 I2D: score=4 STRING: ENSP00000360683
    TOPBP1Q925473, ENSP000002608104I2D: score=1 STRING: ENSP00000260810
    FANCMQ8IYD83, ENSP000002674304I2D: score=1 STRING: ENSP00000267430
    ATRQ135353, ENSP000003437414I2D: score=1 STRING: ENSP00000343741
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9637771
    GO:0010212response to ionizing radiation IMP--
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0032526response to retinoic acid IEA--
    GO:0042221response to chemical stimulus ----


    CLK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLK2

    2 HMDB Compounds for CLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about CLK2 

    Transcripts
    for CLK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLK2 gene (2 alternative transcripts): 
    NM_003993.2  NM_001291.2  

    Unigene Cluster for CLK2:

    CDC-like kinase 2
    Hs.73986  [show with all ESTs]
    Unigene Representative Sequence: AK091036
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361168 ENST00000368361(uc001fjw.3 uc001fjy.3 uc001fjx.3 uc009wqm.3)
    ENST00000476983 ENST00000355560 ENST00000497188 ENST00000471047 ENST00000484699
    ENST00000536801

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLK2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CLK2:
    hsa-miR-3163 hsa-miR-3690 hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-340 hsa-miR-548u hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: CLK2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK2 (see all 7)
    OriGene shRNA RFP: CLK2
    OriGene siRNA: CLK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK2
    Clone
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    Additional cDNA sequence: 

    AK091036.1 AK291995.1 AK303696.1 BC006274.2 BC014067.2 BC053603.1 L29216.1 L29218.1 

    14 DOTS entries:

    DT.314746  DT.95155137  DT.91775599  DT.100058931  DT.95262254  DT.121427755  DT.92033405  DT.441421 
    DT.100035132  DT.100675800  DT.121427728  DT.95314406  DT.101975537  DT.97768072 

    24/369 AceView cDNA sequences (see all 369):

    BQ067887 AI440441 BQ643361 AX748059 AI379352 BM458698 AW410495 CA417291 
    BC007444 CD742665 CA440266 BE744463 AA252054 Z42024 BC014067 BM971663 
    AW170535 CB850653 Z38316 NM_001291 BU506858 L29216 BU501978 BE741472 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CLK2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                      -                       -     -                 -                             -     -                                 
    SP2:                                      -                       -     -                 -                             -     -                                 
    SP3:                                      -                       -     -     -     -     -                             -     -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                      -                       -     -                 -                                                                     

    ExUns: 13 ^ 14 ^ 15a · 15b
    SP1:        -               
    SP2:        -               
    SP3:        -               
    SP4:        -               
    SP5:                        


    ECgene alternative splicing isoforms for CLK2

    Expression
    for CLK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTATAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK2

    SOURCE GeneReport for Unigene cluster: Hs.73986

    UniProtKB/Swiss-Prot: CLK2_HUMAN, P49760
    Tissue specificity: Endothelial cells

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    In Situ
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    Orthologs
    for CLK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK2 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLK21 CDC-like kinase 2 78.45(n)
    89.49(a)    		   425060  NM_001031326.1  NP_001026497.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLK26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343519.1(551025-567101)
    African clawed frog
    (Xenopus laevis)    		 Amphibia clk2-prov2 CDC-like kinase 2 78.02(n)    BC043963.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb20c022 Danio rerio cDNA clone IMAGE5604666, partial cds 71.47(n)    BC057521.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Doa1 Darkener of apricot 58.3(n)
    61.66(a)    		   43415  NM_176581.4  NP_788758.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1726
    		 Temporarily Assigned Gene name family member (tag-...
    		 25(a)
    		 1 → many
    		 X(14284798-14293923)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons FC21 serine/threonine-protein kinase AFC2 54.34(n)
    50.89(a)    		   828576  NM_118607.2  NP_194205.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.357122 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.81(n)    AK066167.1 


    ENSEMBL Gene Tree for CLK2 (if available)
    TreeFam Gene Tree for CLK2 (if available) 

    Paralogs
    for CLK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK2 gene
    CLK32  PRPF4B2  CLK12  CLK42  
    8 SIMAP similar genes for CLK2 using alignment to 5 protein entries:     CLK2_HUMAN (see all proteins):
    LOC402468    CLK1    CLK3    CLK4    DYRK4    PRPF4B
    HIPK1    HIPK2

    CLK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLK2
    PGOHUM00000232616


    Genomic Variants
    for CLK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/225 NCBI SNPs in CLK2 are shown (see all 225)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs665086201,2
    		C--126602301(+) AATAC-/AAAAAA 1 -- int10--------
    rs2002992581,2
    		--155232356(+) AACCT-/GAGTTTC 3 -- us2k1 ds50010--------
    rs785045891,2
    		--155232432(+) CCACAC/TCCGAG 3 -- ds5001 us2k10--------
    rs38871,2
    		C,F--155232768(+) AACTCC/TGTATG 3 -- us2k1 ut31 ese31Minor allele frequency- T:0.43MN 184
    rs412649351,2
    		--155232867(+) TTTACA/GCTATT 3 -- ut31 us2k11Minor allele frequency- G:0.01NA 120
    rs1507987011,2
    		--155232945(+) AAAAGC/TACCAG 3 -- ut31 us2k10--------
    rs1489084821,2
    		F--155233007(+) CTGATC/TGTCAC 3 -- ut31 us2k11Minor allele frequency- T:0.00NA 4518
    rs2004440171,2
    		--155233062(+) AGCCCA/GAAGGC 4 R W mis1 us2k10--------
    rs2022312781,2
    		--155233102(+) CCCAAC/GGTCAG 4 T us2k1 syn10--------
    rs10490901,2
    		C,H--155233115(-) ACCAGC/TTAAGC 4 A V mis1 us2k16Minor allele frequency- T:0.00NS EA NA 410

    HapMap Linkage Disequilibrium report for CLK2 (155232659 - 155248282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CLK2
         6 CNVs: 3315 34719 0395 65020 4257 6789
    Human Gene Mutation Database (HGMD): CLK2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLK2
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    Disorders / Diseases
    for CLK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLK2 for disorders           About GeneDecksing

    OMIM gene information: 602989    OMIM disorders: --

    8 diseases for CLK2:    About MalaCards
    dna topoisomerase i    corneal dystrophy    fanconi's anemia    gaucher's disease
    anemia    ataxia    hepatitis    malaria


    Export disorders for CLK2 gene to outside databases

    Publications
    for CLK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CLK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2, 3, 9 Hanes J.J.... Scheit K.H. (1994)
    2. Phosphorylation of CLK2 at serine 34 and threonine 12 7 by AKT controls cell survival after ionizing radiation. (PubMed id 20682768)1, 2 Nam S.Y....Jin Y.W. (2010)
    3. Heterogeneous Nuclear Ribonucleoprotein G Regulates Splice Site Selection by Binding to CC(A/C)-rich Regions in Pre-mRNA. (PubMed id 19282290)1, 2 Heinrich B....Stamm S. (2009)
    4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (2003)
    8. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PubMed id 10480872)1, 2 Moeslein F.M....Landreth G.E. (1999)
    9. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (1998)
    10. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. (PubMed id 9637771)1, 2 Duncan P.I.... Bell J.C. (1998)

    External Searches for CLK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1196 HGNC: 2069 AceView: CLK2andC1orf2 Ensembl:ENSG00000176444 euGenes: HUgn1196
    ECgene: CLK2 H-InvDB: CLK2

    Other Databases showing CLK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CLK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLK2 gene:
    Search GeneIP for patents involving CLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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