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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLK1 Gene

protein-coding   GIFtS: 61
GCID: GC02M201717

CDC-like kinase 1
 Explore 6 diseases affiliated with
CLK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLK1    

Aliases
for CLK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CDC-Like Kinase 11 2 3     CLK/STY2
CLK2 3 5     CDC28/CDC2-Like Kinase2
EC 2.7.12.13 8     Dual Specificity Protein Kinase CLK12
STY2 5     Protein Tyrosine Kinase STY2

External Ids:    HGNC: 20681   Entrez Gene: 11952   Ensembl: ENSG000000134417   OMIM: 6019515   UniProtKB: P497593   
ORGUL members:         
NONCODE:n408050 n408051    

Export aliases for CLK1 gene to outside databases

Previous GC identifers: GC02M199934 GC02M200442 GC02M201681 GC02M201920 GC02M201533 GC02M201425 GC02M201417 GC02M193569


Summaries
for CLK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLK1:
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the
encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the
nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of
transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role
in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of
regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1.
Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA

Gene Wiki entry for CLK1


Genomic Views
for CLK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLK1 gene promoter:
         Max1   FOXF2   AML1a   GATA-6   POU2F1   POU2F1a   FOXJ2 (long isoform)   IRF-7A   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

CLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M201717:  view genomic region     (about GC identifiers)

Start:
 201,717,732 bp from pter      End:
 201,729,467 bp from pter
Size:
 11,736 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n408051
  • n408050
201717731 201723599 201729467 chr2

Proteins
for CLK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK1  
Size: 484 amino acids; 57291 Da
Subunit: Interacts with PPIG and UBL5
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for CLK1:
1Z57 (3D)        2VAG (3D)    
Secondary accessions: B4DFW7 Q0P694 Q8N5V8
Alternative splicing: 3 isoforms:  P49759-1   P49759-2   P49759-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLK1: NX_P49759

Post-translational modifications:

  • Autophosphorylates on all three types of residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49759

    • 4 DME Specific Peptides for CLK1 (P49759)
     HICIVFE  EHLAMMER  VSTRHYRAPEVIL  LTHTDLKPENILFV 

    CLK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155879.1  NP_004062.2  

    ENSEMBL proteins: 
     ENSP00000326830   ENSP00000400487   ENSP00000386358   ENSP00000386875   ENSP00000394734  

    Human Recombinant Protein Products: 
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    Novus Biologicals CLK1 Proteins
    Novus Biologicals CLK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLK1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    CLK1 for ontologies           About GeneDecksing



    CLK1 Antibody Products: 
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    Uscn ELISAs and CLIAs for CLK1

    Protein Domains /
    Families
    for CLK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLK1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49759

    ProtoNet protein and cluster: P49759

    UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CLK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates
    serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of
    regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1.
    Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the
    catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the
    kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated
    by phosphorylation of SR proteins (By similarity)

         Genatlas biochemistry entry for CLK1:
    CDC-like kinase 1,with two alternatively spliced forms,one catalytically active and one inactive isoforms,interacting
    with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely expressed

    Enzyme Number (IUBMB): EC 2.7.12.11 2

    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLK1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK1 (see all 7)
    OriGene shRNA RFP: CLK1
    OriGene siRNA: CLK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CLK1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA10480872
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS1825055
    GO:0005524ATP binding IEA--


    CLK1 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for CLK1:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Increased cell number in G1, s  Upregulation of Wnt/beta-caten 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Clk1):
     behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  vision/eye 

    CLK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA processing0.48


    1 BioSystems Pathway for CLK1 
        mRNA processing


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/73 Interacting proteins for CLK1 (P497593 ENSP000003268304) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008283cell proliferation TAS1704889
    GO:0018105peptidyl-serine phosphorylation IEA--
    GO:0018107peptidyl-threonine phosphorylation IEA--
    GO:0018108peptidyl-tyrosine phosphorylation IEA--
    GO:0043484regulation of RNA splicing IMP19168442


    CLK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CLK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KH CB19 Selective, potent inhibitor of CLK1 and 4 --

    2 HMDB Compounds for CLK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for CLK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Debromohymenialdisine-- --target--17139284 17016423
    ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate-- --target--10592235

    1 Novoseek chemical compound relationship for CLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 59.1 1 15010457 (1)

    Search CenterWatch for drugs/clinical trials and news about CLK1 

    Transcripts
    for CLK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLK1 gene (3 alternative transcripts): 
    NM_001162407.1  NM_004071.3  NM_001024646.1  

    Unigene Cluster for CLK1:

    CDC-like kinase 1
    Hs.433732  [show with all ESTs]
    Unigene Representative Sequence: NR_027856
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321356(uc002uwe.2 uc002uwf.2) ENST00000461981 ENST00000464454
    ENST00000432425 ENST00000473565(uc002uwg.2) ENST00000472679 ENST00000409769
    ENST00000409403 ENST00000434813(uc010zhi.1) ENST00000461326 ENST00000496205
    ENST00000492793 ENST00000481641 ENST00000482590

    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CLK1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLK1 (see all 7)
    OriGene shRNA RFP: CLK1
    OriGene siRNA: CLK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLK1
    Clone
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    Additional cDNA sequence: 

    AK289365.1 AK294295.1 AK307301.1 AK316127.1 BC028149.1 BC031549.1 NR_027855.1 NR_027856.1 

    24/31 DOTS entries (see all 31):

    DT.95348099  DT.95115426  DT.120946716  DT.95103963  DT.95115438  DT.95115389  DT.452517  DT.100827505 
    DT.100032036  DT.100827492  DT.100827497  DT.101984804  DT.95115424  DT.92446020  DT.120946582  DT.95115392 
    DT.100664781  DT.100827499  DT.100827501  DT.120946595  DT.120946746  DT.92446021  DT.100001224  DT.92446024 

    24/425 AceView cDNA sequences (see all 425):

    BG572299 BU633346 BM975450 AA321313 AW151564 AI354626 CD617942 BE326407 
    BM982780 CA849081 AU119106 BP379138 BM929426 BC028573 BP340934 AU107248 
    BF445818 BE464658 CR617472 CD617940 BP371236 CR609176 AU107250 AA398210 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CLK1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^
    SP1:                          -     -     -                                   -     -     -     -           -     -           -     -                 -         
    SP2:                          -     -     -                                   -     -     -     -     -     -     -           -     -                 -         
    SP3:                                                                          -     -     -     -           -     -           -     -                           
    SP4:                          -     -     -                             -     -     -     -     -     -     -     -           -     -                           
    SP5:                                                                                                                          -     -                 -         

    ExUns: 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                    -                           
    SP2:                    -                           
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CLK1

    Expression
    for CLK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CLK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLK1

    SOURCE GeneReport for Unigene cluster: Hs.433732

    UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
    Tissue specificity: Endothelial cells

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    In Situ
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    Orthologs
    for CLK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK1 gene from 7/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLK11 CDC-like kinase 1 74.46(n)
    76.63(a)    		   100858576  XM_003641583.1  XP_003641631.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLK16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 1(118106737-118115154)
    zebrafish
    (Danio rerio)    		 Actinopterygii clk4b6
    clk4a6
    		 CDC-like kinase 4a
    		 55(a)
    53(a)
    		 many ↔ many
    many ↔ many
    		 21(31048181-31068381)
    14(6900178-6910138)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Doa3 NOT MAPKKK cascade protein serine/threonine
    kinase less    		 60(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1726
    		 Temporarily Assigned Gene name family member (tag-...
    		 21(a)
    		 1 → many
    		 X(14284798-14293923)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AME36
    AFC26
    (see all 3)    		 serine/threonine-protein kinase AFC2
    (see all 3)    		 39(a)
    37(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(15756128-15759314)
    4(12754529-12757786)
    rice
    (Oryza sativa)    		 Liliopsida NM_190508.12   -- 74.34(n)    NM_190508.1 


    ENSEMBL Gene Tree for CLK1 (if available)
    TreeFam Gene Tree for CLK1 (if available) 

    Paralogs
    for CLK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLK1 gene
    CLK32  PRPF4B2  CLK42  CLK22  
    11 SIMAP similar genes for CLK1 using alignment to 3 protein entries:     CLK1_HUMAN (see all proteins):
    DKFZp686A20267    CLK2    LOC402468    CLK4    CLK3    DYRK4
    DYRK2    PRPF4B    HIPK2    DYRK1A    HIPK1

    CLK1 for paralogs           About GeneDecksing



    Genomic Variants
    for CLK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/274 NCBI SNPs in CLK1 are shown (see all 274)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2017227481,2
    		--201717274(+) GGGAA-/AAAG  
                AAAGA     		4 -- ds50010--------
    rs785295341,2
    		F,--201717290(+) CAGAGA/GAAGAG 4 -- ds50011Minor allele frequency- G:0.08WA 118
    rs1485802441,2
    		C,--201717301(+) AAAAA-/AGAG  
                AGAGA     		4 -- ds50010--------
    rs729270911,2
    		--201717312(+) AGAGAC/GGAGAG 4 -- ds50010--------
    rs1142634341,2
    		F,--201717408(+) CATAGA/GTGAAA 4 -- ds50011Minor allele frequency- G:0.02WA 118
    rs32169941,2
    		C,F,--201717460(-) GTCTGTG/-AATTT 4 -- ds50012Minor allele frequency- -:0.50CSA 4
    rs1874919721,2
    		--201717709(+) GACTTG/TAGGAA 4 -- ds50010--------
    rs1397918561,2
    		--201717768(+) AAAAAC/TGGTAC 4 -- nc-transcript-variantut310--------
    rs1927965791,2
    		--201717798(+) TACATA/GTCAAC 4 -- nc-transcript-variantut310--------
    rs1438651481,2
    		--201717887(+) CTTAAA/TGAACC 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for CLK1 (201717732 - 201729467 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLK1: --

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    Disorders / Diseases
    for CLK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLK1 for disorders           About GeneDecksing

    OMIM gene information: 601951    OMIM disorders: --

    6 diseases for CLK1:    About MalaCards
    dna topoisomerase i    ureteral obstruction    huntington's disease    influenza
    malaria    carcinoma


    Export disorders for CLK1 gene to outside databases

    Publications
    for CLK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLK1 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with CLK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human cdc2/CDC28-like protein kinase. (PubMed id 1704889)1, 2, 9 Johnson K.W. and Smith K.A. (1991)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A....Rauch U. (2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (2003)
    6. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PubMed id 10480872)1, 2 Moeslein F.M....Landreth G.E. (1999)
    7. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (1998)
    8. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2 Hanes J.J.... Scheit K.H. (1994)
    9. Manipulation of alternative splicing by a newly developed inhibitor of Clks. (PubMed id 15010457)1, 9 Muraki M....Hagiwara M. (2004)
    10. Differential effect of CLK SR Kinases on HIV-1 gene e xpression: potential novel targets for therapy. (PubMed id 21682887)1 Wong R....Cochrane A. (2011)

    External Searches for CLK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing CLK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1195 HGNC: 2068 AceView: CLK1 Ensembl:ENSG00000013441 euGenes: HUgn1195
    ECgene: CLK1 H-InvDB: CLK1

    Other Databases showing CLK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLK1 gene:
    Search GeneIP for patents involving CLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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