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CLK1 Gene

protein-coding   GIFtS: 64
GCID: GC02M201717

CDC-Like Kinase 1

  See CLK1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CDC-Like Kinase 11 2 3     CLK/STY2
CLK2 3 5     CDC28/CDC2-Like Kinase2
EC 2.7.12.13 8     Dual Specificity Protein Kinase CLK12
STY2 5     Protein Tyrosine Kinase STY2

External Ids:    HGNC: 20681   Entrez Gene: 11952   Ensembl: ENSG000000134417   OMIM: 6019515   UniProtKB: P497593   
ORGUL members:         

Export aliases for CLK1 gene to outside databases

Previous GC identifers: GC02M199934 GC02M200442 GC02M201681 GC02M201920 GC02M201533 GC02M201425 GC02M201417 GC02M193569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLK1 Gene:
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the
nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing,
releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by
the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein
may play an indirect role in governing splice site selection. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for CLK1 Gene:
CLK1 (CDC-like kinase 1) is a protein-coding gene. Diseases associated with CLK1 include 3mc syndrome 2. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3
and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus
E1A pre-mRNA

Gene Wiki entry for CLK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLK1 gene promoter:
         Max1   FOXF2   AML1a   GATA-6   POU2F1   POU2F1a   FOXJ2 (long isoform)   IRF-7A   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLK1 promoter sequence
   Search Chromatin IP Primers for CLK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

CLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLK1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M201717:  view genomic region     (about GC identifiers)

Start:
201,717,732 bp from pter      End:
201,729,467 bp from pter
Size:
11,736 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CLK1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759 (See protein sequence)
Recommended Name: Dual specificity protein kinase CLK1  
Size: 484 amino acids; 57291 Da
Subunit: Interacts with PPIG and UBL5
2 PDB 3D structures from and Proteopedia for CLK1:
1Z57 (3D)        2VAG (3D)    
Secondary accessions: B4DFW7 Q0P694 Q8N5V8
Alternative splicing: 3 isoforms:  P49759-1   P49759-2   P49759-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLK1: NX_P49759

Explore proteomics data for CLK1 at MOPED

Post-translational modifications: 

  • Autophosphorylates on all three types of residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CLK1 (P49759)
     HICIVFE  EHLAMMER  VSTRHYRAPEVIL  LTHTDLKPENILFV 


    See CLK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155879.1  NP_004062.2  

    ENSEMBL proteins: 
     ENSP00000326830   ENSP00000400487   ENSP00000386358   ENSP00000386875   ENSP00000394734  

    CLK1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLK1
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    Novus Biologicals CLK1 Proteins
    Novus Biologicals CLK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLK1

     
    Search eBioscience for Proteins for CLK1 

    CLK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. ELISAs for CLK1
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    Search eBioscience for ELISAs for CLK1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLK: CDC-like kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: CDC-like kinase 1
    CLK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49759

    ProtoNet protein and cluster: P49759

    UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CLK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLK1_HUMAN, P49759
    Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.
    Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a
    network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3
    and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus
    E1A pre-mRNA
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression
    of the catalytically active form influences splicing to generate the catalytically inactive splicing variant
    lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative
    splicing mediated by phosphorylation of SR proteins (By similarity)

         Genatlas biochemistry entry for CLK1:
    CDC-like kinase 1,with two alternatively spliced forms,one catalytically active and one inactive
    isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely
    expressed

         Enzyme Number (IUBMB): EC 2.7.12.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10480872
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS1825055
         
    Find genes that share ontologies with CLK1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CLK1:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Increased cell number in G1, s  Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clk1):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  vision/eye 

    Find genes that share phenotypes with CLK1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLK1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLK1:
    hsa-mir-215-5p (MIRT024633), hsa-mir-186-5p (MIRT045167), hsa-mir-192-5p (MIRT026392)

    Block miRNA regulation of human, mouse, rat CLK1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CLK1:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLK1

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    GenScript: all cDNA clones in your preferred vector (see all 2): CLK1 (NM_004071)
    Sino Biological Human cDNA Clone for CLK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLK1
    Addgene plasmids for CLK1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLK1_HUMAN, P49759: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CLK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLK1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Legionellosis
    Legionellosis


    Find genes that share SuperPaths with CLK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CLK1
        mRNA processing



    1 Kegg Pathway  (Kegg details for CLK1):
        Legionellosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLK1
    Interactions:

        GeneGlobe Interaction Network for CLK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLK1 (P497593 ENSP000003268304) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0008283cell proliferation TAS1704889
    GO:0018105peptidyl-serine phosphorylation IEA--
    GO:0018107peptidyl-threonine phosphorylation IEA--
    GO:0018108peptidyl-tyrosine phosphorylation ----

    Find genes that share ontologies with CLK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CLK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    2 HMDB Compounds for CLK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for CLK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Debromohymenialdisine-- --target--17139284 17016423
    ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate-- --target--10592235

    1 Novoseek inferred chemical compound relationship for CLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 59.1 1 15010457 (1)



    Find genes that share compounds with CLK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLK1 gene (3 alternative transcripts): 
    NM_001162407.1  NM_004071.3  NM_001024646.1  

    Unigene Cluster for CLK1:

    CDC-like kinase 1
    Hs.433732  [show with all ESTs]
    Unigene Representative Sequence: NR_027856
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321356(uc002uwe.2 uc002uwf.2) ENST00000461981 ENST00000464454
    ENST00000432425 ENST00000473565(uc002uwg.2) ENST00000472679 ENST00000409769
    ENST00000409403 ENST00000434813(uc010zhi.1) ENST00000461326 ENST00000496205
    ENST00000492793 ENST00000481641 ENST00000482590
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CLK1:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-151-3p
    SwitchGear 3'UTR luciferase reporter plasmidCLK1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for CLK1 
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      QuantiTect SYBR Green Assays in human, mouse, rat CLK1
      QuantiFast Probe-based Assays in human, mouse, rat CLK1

    Additional mRNA sequence: 

    AK289365.1 AK294295.1 AK307301.1 AK316127.1 BC028149.1 BC031549.1 NR_027855.1 NR_027856.1 

    Selected DOTS entries (see all 31):

    DT.95348099  DT.95115426  DT.120946716  DT.95103963  DT.95115438  DT.95115389  DT.452517  DT.100827505 
    DT.100032036  DT.100827492  DT.100827497  DT.101984804  DT.95115424  DT.92446020  DT.120946582  DT.95115392 
    DT.100664781  DT.100827499  DT.100827501  DT.120946595  DT.120946746  DT.92446021  DT.100001224  DT.92446024 

    Selected AceView cDNA sequences (see all 425):

    AA287250 BM955826 AU107251 BC028573 AI056204 BC028149 AA412072 AA371192 
    CD238163 BP343078 AL040956 CD107620 BG548807 BX422307 CR591789 AA461111 
    AA541513 BG697156 BP378024 BQ719896 AK025306 CD676471 BM905853 CB152439 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CLK1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^
    SP1:                          -     -     -                                   -     -     -     -           -     -           -     -                 -         
    SP2:                          -     -     -                                   -     -     -     -     -     -     -           -     -                 -         
    SP3:                                                                          -     -     -     -           -     -           -     -                           
    SP4:                          -     -     -                             -     -     -     -     -     -     -     -           -     -                           
    SP5:                                                                                                                          -     -                 -         

    ExUns: 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                    -                           
    SP2:                    -                           
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CLK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLK1 Expression
    About this image


    CLK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thymus (Hematopoietic System)
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    CLK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433732

    UniProtKB/Swiss-Prot: CLK1_HUMAN, P49759
    Tissue specificity: Endothelial cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLK1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clk11 , 5 CDC-like kinase 11, 5 88.15(n)1
    90.02(a)1
      1 (29.09 cM)5
    127471  NM_001042634.21  NP_001036099.11 
     584101895 
    chicken
    (Gallus gallus)
    Aves CLK11 CDC-like kinase 1 73.68(n)
    76(a)
      100858576  XM_003641583.2  XP_003641631.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLK16
    CDC-like kinase 1
    79(a)
    1 ↔ 1
    1(118106725-118120419)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clk11 CDC-like kinase 1 70.32(n)
    71.18(a)
      549675  NM_001016921.2  NP_001016921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clk4b6
    clk4a6
    CDC-like kinase 4a
    58(a)
    56(a)
    many ↔ many
    many ↔ many
    21(31048181-31068381) ENSDARG00000005908
    14(6900178-6910138) ENSDARG00000089372
    fruit fly
    (Drosophila melanogaster)
    Insecta Doa3 NOT MAPKKK cascade protein
    serine/threonine kinase less
    60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1726
    Protein TAG-172, isoform a (tag-172) mRNA, complet...
    23(a)
    1 → many
    X(14284868-14293993) WBGene00006517
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS1(YLL019C)4 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues less   --   12(107899-105686) 850641  NP_013081.1 
    rice
    (Oryza sativa)
    Liliopsida NM_190508.12   -- 74.34(n)    NM_190508.1 


    ENSEMBL Gene Tree for CLK1 (if available)
    TreeFam Gene Tree for CLK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLK1 gene
    CLK32  PRPF4B2  CLK42  CLK22  
    9 SIMAP similar genes for CLK1 using alignment to 3 protein entries:     CLK1_HUMAN (see all proteins):
    DKFZp686A20267    CLK2    LOC402468    CLK4    CLK3    DYRK4
    DYRK2    PRPF4B    HIPK2

    Find genes that share paralogs with CLK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLK1 (see all 385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017227481,2
    C--201717274(+) GGGAA-/AAAG  
            
    AAAGA
    4 -- ds50010--------
    rs785295341,2
    C,F--201717290(+) CAGAGA/GAAGAG 4 -- ds50011Minor allele frequency- G:0.08WA 118
    rs1485802441,2
    C--201717301(+) AAAAA-/AGAG  
            
    AGAGA
    4 -- ds50010--------
    rs729270911,2
    --201717312(+) AGAGAC/GGAGAG 4 -- ds50010--------
    rs1142634341,2
    F--201717408(+) CATAGA/GTGAAA 4 -- ds50011Minor allele frequency- G:0.02WA 118
    rs32169941,2
    C,F--201717460(-) GTCTGTG/-AATTT 4 -- ds50012Minor allele frequency- -:0.50CSA 4
    rs1874919721,2
    C--201717709(+) GACTTG/TAGGAA 4 -- ds50010--------
    rs1397918561,2
    C--201717768(+) AAAAAC/TGGTAC 4 -- ut31 nc-transcript-variant0--------
    rs1927965791,2
    --201717798(+) TACATA/GTCAAC 4 -- ut31 nc-transcript-variant0--------
    rs1438651481,2
    --201717887(+) CTTAAA/TGAACC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CLK1 (201717732 - 201729467 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CLK1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CLK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601951    OMIM disorders: --

    1 disease for CLK1:    
    About MalaCards
    3mc syndrome 2


    Find genes that share disorders with CLK1           About GenesLikeMe


    Export disorders for CLK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLK1 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with CLK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human cdc2/CDC28-like protein kinase. (PubMed id 1704889)1, 2, 9 Johnson K.W. and Smith K.A. (J. Biol. Chem. 1991)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2 Eisenreich A.... Rauch U. (Circ. Res. 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    5. Beacon interacts with cdc2/cdc28-like kinases. (PubMed id 12705895)1, 2 Kantham L.... Collier G. (Biochem. Biophys. Res. Commun. 2003)
    6. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PubMed id 10480872)1, 2 Moeslein F.M.... Landreth G.E. (J. Biol. Chem. 1999)
    7. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PubMed id 9856501)1, 3 Talmadge C.B....Rabinow L. (Hum. Genet. 1998)
    8. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PubMed id 7990150)1, 2 Hanes J.J.... Scheit K.H. (J. Mol. Biol. 1994)
    9. Manipulation of alternative splicing by a newly developed inhibitor of Clks. (PubMed id 15010457)1, 9 Muraki M....Hagiwara M. (J. Biol. Chem. 2004)
    10. Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. (PubMed id 23707382)1 Aubol B.E....Adams J.A. (J. Mol. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1195 HGNC: 2068 AceView: CLK1 Ensembl:ENSG00000013441 euGenes: HUgn1195
    ECgene: CLK1 Kegg: 1195 H-InvDB: CLK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLK1 gene:
    Search GeneIP for patents involving CLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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