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Aliases for CLIP4 Gene

Aliases for CLIP4 Gene

  • CAP-Gly Domain Containing Linker Protein Family Member 4 2 3 5
  • CAP-GLY Domain Containing Linker Protein Family, Member 4 2 3
  • Restin-Like Protein 2 3 4
  • RSNL2 3 4
  • CAP-Gly Domain-Containing Linker Protein 4 3
  • Restin-Like 2 2

External Ids for CLIP4 Gene

Previous HGNC Symbols for CLIP4 Gene

  • RSNL2

Previous GeneCards Identifiers for CLIP4 Gene

  • GC02P029191
  • GC02P029320

Summaries for CLIP4 Gene

GeneCards Summary for CLIP4 Gene

CLIP4 (CAP-Gly Domain Containing Linker Protein Family Member 4) is a Protein Coding gene. An important paralog of this gene is CLIP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIP4 Gene

Genomics for CLIP4 Gene

Regulatory Elements for CLIP4 Gene

Enhancers for CLIP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CLIP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLIP4 Gene

Chromosome:
2
Start:
29,097,676 bp from pter
End:
29,189,643 bp from pter
Size:
91,968 bases
Orientation:
Plus strand

Genomic View for CLIP4 Gene

Genes around CLIP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP4 Gene

Proteins for CLIP4 Gene

  • Protein details for CLIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3C7-CLIP4_HUMAN
    Recommended name:
    CAP-Gly domain-containing linker protein 4
    Protein Accession:
    Q8N3C7
    Secondary Accessions:
    • A0AV10
    • B2RMQ3
    • B7Z7N8
    • Q7Z4U3
    • Q96BR7
    • Q96MA5
    • Q9H7C0

    Protein attributes for CLIP4 Gene

    Size:
    705 amino acids
    Molecular mass:
    76317 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLIP4 Gene

    Alternative splice isoforms for CLIP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIP4 Gene

Post-translational modifications for CLIP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLIP4 Gene

Domains & Families for CLIP4 Gene

Gene Families for CLIP4 Gene

Protein Domains for CLIP4 Gene

Suggested Antigen Peptide Sequences for CLIP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3C7

UniProtKB/Swiss-Prot:

CLIP4_HUMAN :
  • Contains 3 CAP-Gly domains.
  • Contains 3 ANK repeats.
Domain:
  • Contains 3 CAP-Gly domains.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with CLIP4: view

Function for CLIP4 Gene

Gene Ontology (GO) - Molecular Function for CLIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CLIP4: view
genes like me logo Genes that share phenotypes with CLIP4: view

Animal Model Products

CRISPR Products

miRNA for CLIP4 Gene

miRTarBase miRNAs that target CLIP4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLIP4 Gene

Localization for CLIP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIP4 Gene COMPARTMENTS Subcellular localization image for CLIP4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CLIP4 Gene

Pathways & Interactions for CLIP4 Gene

SuperPathways for CLIP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLIP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLIP4 Gene

Drugs & Compounds for CLIP4 Gene

No Compound Related Data Available

Transcripts for CLIP4 Gene

Unigene Clusters for CLIP4 Gene

CAP-GLY domain containing linker protein family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for CLIP4 Gene

GeneLoc Exon Structure for
CLIP4
ECgene alternative splicing isoforms for
CLIP4

Expression for CLIP4 Gene

mRNA expression in normal human tissues for CLIP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIP4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for CLIP4 Gene

This gene is overexpressed in Cerebrospinal fluid (33.6), Breast (11.0), Plasma (10.2), and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLIP4 Gene



Protein tissue co-expression partners for CLIP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CLIP4 Gene:

CLIP4

SOURCE GeneReport for Unigene cluster for CLIP4 Gene:

Hs.122927
genes like me logo Genes that share expression patterns with CLIP4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CLIP4 Gene

Orthologs for CLIP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLIP4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CLIP4 34
  • 88.38 (n)
  • 90.18 (a)
CLIP4 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clip4 34
  • 82.77 (n)
  • 87.64 (a)
Clip4 16
Clip4 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLIP4 34
  • 99.57 (n)
  • 99.43 (a)
CLIP4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clip4 34
  • 83.95 (n)
  • 87.63 (a)
cow
(Bos Taurus)
Mammalia CLIP4 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLIP4 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIP4 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLIP4 34
  • 75.15 (n)
  • 76.39 (a)
CLIP4 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIP4 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495216 34
  • 63.6 (n)
  • 67.4 (a)
zebrafish
(Danio rerio)
Actinopterygii CLIP4 (1 of 2) 35
  • 66 (a)
OneToMany
CLIP4 (2 of 2) 35
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP100 35
  • 4 (a)
OneToMany
Species where no ortholog for CLIP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP4 Gene

ENSEMBL:
Gene Tree for CLIP4 (if available)
TreeFam:
Gene Tree for CLIP4 (if available)

Paralogs for CLIP4 Gene

Paralogs for CLIP4 Gene

(2) SIMAP similar genes for CLIP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CLIP4: view

Variants for CLIP4 Gene

Sequence variations from dbSNP and Humsavar for CLIP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3100246 - 29,160,390(+) ACTCC(G/T)CCTCG nc-transcript-variant, reference, missense
rs34327508 - 29,181,612(-) TGCGG(G/T)GGGGG nc-transcript-variant, reference, synonymous-codon, missense
rs2166594 -- 29,119,331(-) AGATA(C/T)GAACT intron-variant
rs2197620 -- 29,117,302(-) AAAAA(A/T)TATTA intron-variant, nc-transcript-variant
rs6710742 -- 29,110,301(+) GATGG(A/G)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIP4 Gene

Variant ID Type Subtype PubMed ID
dgv6746n54 CNV gain+loss 21841781
esv27586 CNV loss 19812545
esv2759035 CNV gain 17122850
esv34904 CNV gain 17911159
nsv1008490 CNV gain 25217958
nsv2658 CNV deletion 18451855
nsv581248 CNV loss 21841781
nsv581250 CNV gain 21841781
nsv581252 CNV gain 21841781
nsv581253 CNV loss 21841781
nsv998151 CNV loss 25217958

Variation tolerance for CLIP4 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLIP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLIP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP4 Gene

Disorders for CLIP4 Gene

Relevant External Links for CLIP4

Genetic Association Database (GAD)
CLIP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLIP4

No disorders were found for CLIP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIP4 Gene

Publications for CLIP4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 65
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 65

Products for CLIP4 Gene

Sources for CLIP4 Gene

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