CLIP4 Gene
protein-coding GIFtS : 45
GCID: GC02 P029320
CAP-GLY domain containing linker protein family, member... (Previous name: restin-like 2 ) (Previous symbol: RSNL2 )
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Aliasesfor CLIP4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases CAP-GLY Domain Containing Linker Protein Family, Member 4 1 2 RSNL21 2 3 Restin-Like 21 2 Restin-Like Protein 22 3 FLJ210691 CAP-Gly Domain-Containing Linker Protein 42
Export aliases for CLIP4 gene to outside databases Previous GC identifers: GC02P029191 GC02P029085
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Summariesfor CLIP4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor CLIP4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022184.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CLIP4 gene promoter: STAT5A Arnt C/EBPalpha HNF-1A GATA-1 AREB6 E2F-1 E2F HNF-1 TGIF Other transcription factors Search SABiosciences Chromatin IP Primers for CLIP4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLIP4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p23.2 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23 CLIP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P029320: view genomic region
(about GC identifiers )
Start:
29,320,560 bp from pter
End:
29,412,509 bp from pter
Size:
91,950 bases
Orientation:
plus strand
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Proteinsfor CLIP4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CLIP4_HUMAN, Q8N3C7 (See
protein sequence )Recommended Name: CAP-Gly domain-containing linker protein 4 Size : 705 amino acids; 76317 Da
Sequence caution : Sequence=BAB14974.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CLIP4 :2Z0W (3D)
 
Secondary accessions : A0AV10 B2RMQ3 B7Z7N8 Q7Z4U3 Q96BR7 Q96MA5 Q9H7C0Alternative splicing : 4 isoforms : Q8N3C7-1 Q8N3C7-2 Q8N3C7-3 Q8N3C7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CLIP4: NX_Q8N3C7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N3C7 CLIP4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078968.3 ENSEMBL proteins: ENSP00000409704 ENSP00000384242 ENSP00000385148 ENSP00000414417 ENSP00000385594 ENSP00000399029 ENSP00000327009 ENSP00000393354 ENSP00000392296 ENSP00000384533 Human Recombinant Protein Products: CLIP4 Antibody Products: Assay Products for CLIP4:
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Protein
Domains / Familiesfor CLIP4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CLIP4 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N3C7 ProtoNet protein and cluster: Q8N3C7
2 Blocks protein families : IPB000938 CAP-Gly domain IPB002110 Ankyrin repeat signature UniProtKB/Swiss-Prot: CLIP4_HUMAN, Q8N3C7 Similarity : Contains 3 ANK repeatsSimilarity : Contains 3 CAP-Gly domains
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Functionfor CLIP4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLIP4 (NM_024692 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLIP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLIP4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP4
1 GenomeRNAi human phenotype for CLIP4 :
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Pathways & Interactionsfor CLIP4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLIP4 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for CLIP4 (Q8N3C7 3 ENSP00000327009 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor CLIP4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CLIP4 Search CenterWatch for drugs/clinical trials and news about CLIP4
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Transcriptsfor CLIP4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CLIP4 gene: NM_024692.4 Unigene Cluster for CLIP4:
CAP-GLY domain containing linker protein family, member 4 Hs.122927 [show with all ESTs ] Unigene Representative Sequence: AB209042 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000426642 ENST00000401605 (uc002rmu.3 ) ENST00000401617 (uc010ymn.1 )ENST00000415891 ENST00000404424 (uc010ezm.1 ) ENST00000456385 ENST00000320081 (uc002rmv.3 uc002rmw.3 )ENST00000449202 ENST00000491701 ENST00000471165 ENST00000438819 ENST00000493551 ENST00000481628 ENST00000402240 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CLIP4 (NM_024692 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLIP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLIP4
Additional cDNA sequence: AB209042.1 AF433661.1 AK023505.1 AK024722.1 AK057267.1 AK225074.1 AK291595.1 AK302325.1 AK304384.1 AL834443.1 BC013862.1 BC015310.1 BC126167.1 BC136331.1
13 DOTS entries : DT.95265567 DT.307710
DT.433980 DT.95265564 DT.40127062 DT.121028731 DT.121028704 DT.91703201 DT.95265566 DT.101973392 DT.102825819 DT.121028681 DT.75174335 24/118 AceView cDNA sequences (see all 118 ):
BE046484 BU690053 BX470459 NM_024692 AI682339 AW079911 CN481462 BM661494 AA348641 BX093098 AK057267 AA453618 BQ025066 AA501961 AL834443 BE221266 BM126281 AW305133 BM994685 BE043087 BC015310 BM127591 BQ007068 BC013862 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CLIP4 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 SP1 :         -   -                           -         -     SP2 :     -     -   -       -                     -             SP3 :         -   -                       -                 SP4 :   -   -     -   -                                       SP5 :         -   -                                      
ECgene alternative splicing isoforms for CLIP4
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Expression for CLIP4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CLIP4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CACATTAGGT
About this image CLIP4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category Trophoblast-like cells (Generation of tropho... )Embryoid bodies (Two-step protocol fo... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CLIP4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CLIP4 SOURCE GeneReport for Unigene cluster: Hs.122927 SABiosciences Custom PCR Arrays for CLIP4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLIP4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CLIP4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLIP4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLIP4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP4
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Orthologsfor CLIP4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CLIP4 gene from 4/13 species (see all 13 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CLIP41
CAP-GLY domain containing linker protein family, member more
75.74(n) 77.83(a)
 
428556 XM_426112.3 XP_426112.3
lizard (Anolis carolinensis)
Reptilia
CLIP46
--
70(a)
1 ↔ 1
1(248547286-248589714)
African clawed frog (Xenopus laevis)
Amphibia
480454152
--
74.33(n)
 
48045415
zebrafish (Danio rerio)
Actinopterygii
zgc:1037556
zgc:103755
57(a)
possible ortholog
17(47932433-47970812)
ENSEMBL Gene Tree for CLIP4 (if available)TreeFam Gene Tree for CLIP4 (if available)
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Paralogsfor CLIP4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CLIP4 gene CLIP2 2 CEP350 2 CLIP3 2 TBCB 2 CLIP1 2 DCTN1 2 ENSG00000264324 2 2 SIMAP similar genes for CLIP4 using alignment to 8 protein entries: CLIP4_HUMAN (see all proteins ):FLJ21069 CLIP3
CLIP4 for paralogs About GeneDecksing
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Genomic Variantsfor CLIP4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CLIP4 (29320560 - 29412509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for CLIP4 3 CNVs : 2374 3348 8366 1 Indel : 73127
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLIP4
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Disorders
/ Diseasesfor CLIP4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor CLIP4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CLIP4 gene integrated from 9 sources : (articles sorted by number of sources associating them with CLIP4) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for CLIP4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CLIP4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CLIP4 gene
(According to HUGE )
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Specialized Databases showing CLIP4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CLIP4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CLIP4 gene: Search GeneIP for patents involving CLIP4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CLIP4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CLIP4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CLIP4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CLIP4 OriGene Protein Over-expression Lysate for CLIP4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CLIP4 OriGene 3'-UTR Clone for CLIP4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CLIP4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CLIP4 OriGene Custom Protein Services for CLIP4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLIP4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CLIP4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CLIP4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CLIP4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CLIP4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CLIP4
Search Tocris compounds for CLIP4
CLIP4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP4
Search ThermoFisher Antibodies for CLIP4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CLIP4
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Aliases for CLIP4
Databases for CLIP4
Disorders / Diseases for CLIP4
Domains / Families for CLIP4
Drugs / Compounds for CLIP4
Expression for CLIP4
Function for CLIP4
Genomic Views for CLIP4
Intellectual Property for CLIP4
Orthologs for CLIP4
Paralogs for CLIP4
Pathways / Interactions for CLIP4
Products for CLIP4
Proteins for CLIP4
Publications for CLIP4
Search Box for CLIP4
Summaries for CLIP4
Transcripts for CLIP4
Variants for CLIP4
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