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CLIP3 Gene

protein-coding   GIFtS: 50
GCID: GC19M036505

CAP-GLY Domain Containing Linker Protein 3

  Search for CLIP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAP-GLY Domain Containing Linker Protein 31 2     CLIP-170-Related 59 KDa Protein2 3
CLIPR592 3 5     CLIP-170-related1
Restin-Like 11 2     RSNL12
Cytoplasmic Linker Protein 170-Related 59 KDa Protein2 3     CAP-Gly Domain-Containing Linker Protein 32
CLIPR-592 3     

External Ids:    HGNC: 243141   Entrez Gene: 259992   Ensembl: ENSG000001052707   OMIM: 6073825   UniProtKB: Q96DZ53   

Export aliases for CLIP3 gene to outside databases

Previous GC identifers: GC19M041198 GC19M033011


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLIP3 Gene:
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a
cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular
organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and
the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane
localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for
this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CLIP3 Gene:
CLIP3 (CAP-GLY domain containing linker protein 3) is a protein-coding gene. GO annotations related to this gene include microtubule binding and ganglioside binding. An important paralog of this gene is CLIP2.

UniProtKB/Swiss-Prot: CLIP3_HUMAN, Q96DZ5
Function: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular
compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in
glucose transport in adipocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLIP3 gene promoter:
         MAZR   MyoD   Lmo2   FOXO3   E47   FOXO3b   HOXA5   FOXO1a   FOXO3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIP3 promoter sequence
   Search Chromatin IP Primers for CLIP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLIP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13

CLIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036505:  view genomic region     (about GC identifiers)

Start:
36,505,562 bp from pter      End:
36,524,245 bp from pter
Size:
18,684 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLIP3_HUMAN, Q96DZ5 (See protein sequence)
Recommended Name: CAP-Gly domain-containing linker protein 3  
Size: 547 amino acids; 59560 Da
Subunit: Homodimer. Interacts with AKT1 and AKT2; when AKT1 and AKT2 are phosphorylated and activated, affinity is
higher for AKT2
Miscellaneous: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required
1 PDB 3D structure from and Proteopedia for CLIP3:
2CP0 (3D)    
Secondary accessions: A8K0E4 Q8WWL1 Q96C99 Q9UFT7

Explore the universe of human proteins at neXtProt for CLIP3: NX_Q96DZ5

Explore proteomics data for CLIP3 at MOPED

Post-translational modifications: 

  • Palmitoylation by ZDHHC17 regulates association with the plasma membrane1
  • Ubiquitination2 at Lys520
  • Modification sites at PhosphoSitePlus

  • See CLIP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186499.1  NP_056341.1  

    ENSEMBL proteins: 
     ENSP00000353732   ENSP00000466832   ENSP00000468689   ENSP00000466026  

    CLIP3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CLIP3
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    Novus Biologicals CLIP3 Protein
    Novus Biologicals CLIP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLIP3

     
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    LSBio Antibodies in human, mouse, rat for CLIP3

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    Cloud-Clone Corp. ELISAs for CLIP3
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    Search eBioscience for ELISAs for CLIP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR000938 CAP-Gly_domain
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96DZ5

    ProtoNet protein and cluster: Q96DZ5

    2 Blocks protein domains:
    IPB000938 CAP-Gly domain
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: CLIP3_HUMAN, Q96DZ5
    Domain: Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 2 CAP-Gly domains


    Find genes that share domains with CLIP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIP3_HUMAN, Q96DZ5
    Function: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular
    compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in
    glucose transport in adipocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding IMP--
    GO:0035594ganglioside binding IDA--
         
    Find genes that share ontologies with CLIP3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Clip3):
     homeostasis/metabolism  mortality/aging  muscle  nervous system  respiratory system 

    Find genes that share phenotypes with CLIP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Clip3tm1.1Ics for CLIP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLIP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLIP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLIP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLIP3

    miRNA
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    miRTarBase miRNAs that target CLIP3:
    hsa-mir-335-5p (MIRT018271)

    Block miRNA regulation of human, mouse, rat CLIP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLIP3 (see all 45):
    hsa-miR-3938 hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-486-3p hsa-miR-624 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidCLIP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLIP3
    Predesigned siRNA for gene silencing in human, mouse, rat CLIP3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CLIP3 (see all 6)
    OriGene ORF clones in mouse, rat for CLIP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLIP3 (NM_015526)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLIP3_HUMAN, Q96DZ5: Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to
    Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005795Golgi stack IEA--
    GO:0005802trans-Golgi network ISS--
    GO:0005886plasma membrane IMP15262990
    GO:0031901early endosome membrane IDA11854307
    GO:0032588trans-Golgi network membrane IMP15262990

    Find genes that share ontologies with CLIP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLIP3
    Interactions:

        Search GeneGlobe Interaction Network for CLIP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CLIP3 (Q96DZ53 ENSP000003537324) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCGP051293I2D: score=2 
    AKT1P317493I2D: score=1 
    AKT2P317513I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    CKAP5ENSP000003465664STRING: ENSP00000346566
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0010828positive regulation of glucose transport ISS--
    GO:0018230peptidyl-L-cysteine S-palmitoylation IMP15262990
    GO:0031115negative regulation of microtubule polymerization IMP15262990
    GO:0043065positive regulation of apoptotic process IMP--

    Find genes that share ontologies with CLIP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLIP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLIP3 gene (2 alternative transcripts): 
    NM_001199570.1  NM_015526.2  

    Unigene Cluster for CLIP3:

    CAP-GLY domain containing linker protein 3
    Hs.466539  [show with all ESTs]
    Unigene Representative Sequence: NM_001199570
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360535(uc010eeq.2 uc002ocz.2) ENST00000593074 ENST00000585466
    ENST00000592017 ENST00000590559 ENST00000586457
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CLIP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLIP3 (see all 45):
    hsa-miR-3938 hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-486-3p hsa-miR-624 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidCLIP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CLIP3
    Predesigned siRNA for gene silencing in human, mouse, rat CLIP3
    Clone
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    OriGene ORF clones in mouse, rat for CLIP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLIP3 (NM_015526)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIP3
    Primer
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    OriGene qPCR primer pairs and template standards for CLIP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CLIP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLIP3
      QuantiTect SYBR Green Assays in human, mouse, rat CLIP3
      QuantiFast Probe-based Assays in human, mouse, rat CLIP3

    Additional mRNA sequence: 

    AJ427922.1 AK056445.1 AK090732.1 AK092354.1 AK094738.1 AK289509.1 AK294748.1 AL110254.1 
    AL117468.1 BC013116.1 BC014486.1 BC128090.1 

    18 DOTS entries:

    DT.100814048  DT.100814049  DT.100769524  DT.92041890  DT.450253  DT.95312646  DT.100814050  DT.95312599 
    DT.121465224  DT.121465243  DT.121465280  DT.92418511  DT.102833405  DT.121465241  DT.121465290  DT.121465301 
    DT.95209940  DT.99963088 

    Selected AceView cDNA sequences (see all 257):

    AI914439 CN483846 AK090732 T32142 BQ006380 BP361015 BQ670139 NM_015526 
    AA972275 CB156703 AK092354 BF507551 BM708969 AI288440 BE765941 CA391994 
    BC013116 BE765947 AI146378 BE766503 AI674403 AI218217 BP347330 AW768309 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLIP3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                                                                                                              
    SP2:                    -     -     -     -     -     -     -                                                                     
    SP3:                          -     -     -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for CLIP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLIP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCCTGTCC
    CLIP3 Expression
    About this image


    CLIP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Brain (Nervous System)
             Cerebral Cortex
    CLIP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLIP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466539
        Custom PCR Arrays for CLIP3
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    QuantiFast Probe-based Assays in human, mouse, rat CLIP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CLIP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clip31 , 5 CAP-GLY domain containing linker protein 31, 5 89.34(n)1
    98.54(a)1
      7 (17.37 cM)5
    766861  NM_001081114.11  NP_001074583.11 
     302916725 
    lizard
    (Anolis carolinensis)
    Reptilia CLIP36
    CAP-GLY domain containing linker protein 3
    59(a)
    1 ↔ 1
    GL344980.1(3161-14728)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia clip31 CAP-GLY domain containing linker protein 3 71.86(n)
    82.07(a)
      100145183  NM_001126673.1  NP_001120145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clip31 CAP-GLY domain containing linker protein 3 72.09(n)
    80.23(a)
      562450  XM_005157740.1  XP_005157797.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIP1006
    Large subunit of the dynactin complex, which is in...
    4(a)
    1 → many
    XVI(220167-222773) YPL174C


    ENSEMBL Gene Tree for CLIP3 (if available)
    TreeFam Gene Tree for CLIP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLIP3 gene
    CLIP22  CEP3502  TBCB2  CLIP42  CLIP12  DCTN12  ENSG000002643242  
    2 SIMAP similar genes for CLIP3 using alignment to 2 protein entries:     CLIP3_HUMAN (see all proteins):
    CLIP4    FLJ21069

    Find genes that share paralogs with CLIP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLIP3 (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925890651,2
    C--36507156(+) GGCAGA/C/TGGGGA 2 -- int10--------
    rs1830898351,2
    --36507242(+) TGGCTA/GTGGTT 2 -- int10--------
    rs1505453761,2
    C--36507244(+) CTGTG-/GTGTTTG 2 -- int10--------
    rs1415773761,2
    --36507301(+) CTGGAA/GTGCCA 2 -- int10--------
    rs118814281,2
    C,F,A,H--36507319(+) ATCTCA/GGCTCA 2 -- int13Minor allele frequency- G:0.17NA WA CSA 6
    rs1883708351,2
    --36507375(+) CTCCCA/GAGTAG 2 -- int10--------
    rs1926823411,2
    --36507497(+) CGCCTC/GCCTTG 2 -- int10--------
    rs1845074931,2
    --36507542(+) ACCCCG/TCCCGG 2 -- int10--------
    rs1379537071,2
    --36507612(+) CCCACC/TCGAAA 2 -- int10--------
    rs1156632421,2
    F--36507651(+) CCCTAC/TACCCT 2 -- int11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for CLIP3 (36505562 - 36524245 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CLIP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000212CNV Deletion20482838
    nsv911641CNV Loss21882294
    nsv833815CNV Loss17160897
    dgv51n68CNV Loss17160897
    nsv911638CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607382    OMIM disorders: --


    Find genes that share disorders with CLIP3           About GenesLikeMe


    Export disorders for CLIP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLIP3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CLIP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CLIPR-59, a new trans-Golgi/TGN cytoplasmic linker protein belonging to the CLIP-170 family. (PubMed id 11854307)1, 2, 3 Perez F....Goud B. (J. Cell Biol. 2002)
    2. ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. (PubMed id 19139280)1, 2, 9 Ding J. and Du K. (Mol. Cell. Biol. 2009)
    3. DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane. (PubMed id 24001771)1, 2 Ren W.... Du K. (Mol. Cell. Biol. 2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics. (PubMed id 15262990)1, 9 Lallemand-Breitenbach V....Perez F. (J. Biol. Chem. 2004)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. CLIPR-59 regulates TNF-I+-induced apoptosis by controlling ubiquitination of RIP1. (PubMed id 22297296)1 Fujikura D....Miyazaki T. (amp 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis triggered by CD95/Fas. (PubMed id 20052288)1 Sorice M....Malorni W. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25999 HGNC: 24314 AceView: CLIPR-59 Ensembl:ENSG00000105270 euGenes: HUgn25999
    ECgene: CLIP3 H-InvDB: CLIP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLIP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLIP3 gene:
    Search GeneIP for patents involving CLIP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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