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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIP2 Gene

protein-coding   GIFtS: 52
GCID: GC07P073703

CAP-GLY domain containing linker protein 2

(Previous names: cytoplasmic linker 2, Williams-Beuren syndrome chromosome...)
(Previous symbols: WBSCR4, CYLN2, WBSCR3)
 Explore 9 diseases affiliated with
CLIP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLIP2    

Aliases
for CLIP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CAP-GLY Domain Containing Linker Protein 21 2     Williams-Beuren Syndrome Chromosome Region 31 2
CYLN21 2 3 5     KIAA02911 3
WBSCR41 2 3 5     Cytoplasmic Linker Protein 1152 3
WSCR41 2 3 5     Cytoplasmic Linker Protein 22 3
CLIP-1151 2 3     Williams-Beuren Syndrome Chromosomal Region 3 Protein2 3
WBSCR31 2 3     Williams-Beuren Syndrome Chromosomal Region 4 Protein2 3
CLIP1 2     CAP-Gly Domain-Containing Linker Protein 22
WSCR31 2     Williams-Beuren Syndrome Chromosome Region 42
Cytoplasmic Linker 21 2     

External Ids:    HGNC: 25861   Entrez Gene: 74612   Ensembl: ENSG000001066657   OMIM: 6034325   UniProtKB: Q9UDT63   

Export aliases for CLIP2 gene to outside databases

Previous GC identifers: GC07P073342 GC07P069585


Summaries
for CLIP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLIP2:
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to
mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate
with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in
Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.
Alternative splicing of this gene generates 2 transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLIP2_HUMAN, Q9UDT6
Function: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in
bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of
brain-specific organelle translocations (By similarity)

Gene Wiki entry for CLIP2


Genomic Views
for CLIP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIP2 gene promoter:
         FOXD1   HNF-3beta   E47   HNF-1A   FOXL1   HNF-1   Zic1   FOXO1a   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CLIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

CLIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P073703:  view genomic region     (about GC identifiers)

Start:
 73,703,805 bp from pter      End:
 73,820,273 bp from pter
Size:
 116,469 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 73,036,877-73,153,345     

Proteins
for CLIP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLIP2_HUMAN, Q9UDT6 (See protein sequence)
Recommended Name: CAP-Gly domain-containing linker protein 2  
Size: 1046 amino acids; 115837 Da
Subunit: Interacts with CLASP1 and CLASP2
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the
cytoskeleton (By similarity)
Sequence caution: Sequence=BAA22960.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CLIP2:
2CP2 (3D)        2CP3 (3D)    
Secondary accessions: O14527 O43611
Alternative splicing: 2 isoforms:  Q9UDT6-1   Q9UDT6-2   

Explore the universe of human proteins at neXtProt for CLIP2: NX_Q9UDT6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UDT6

    • CLIP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003379.3  NP_115797.1  

    ENSEMBL proteins: 
     ENSP00000355151   ENSP00000378500   ENSP00000417597   ENSP00000419938   ENSP00000223398  

    Human Recombinant Protein Products: 
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    Uscn Proteins for CLIP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005875microtubule associated complex TAS9799601
    GO:0005881cytoplasmic microtubule IEA--


    CLIP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLIP2

    Protein Domains /
    Families
    for CLIP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLIP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000938 CAP-Gly_domain

    Graphical View of Domain Structure for InterPro Entry Q9UDT6

    ProtoNet protein and cluster: Q9UDT6

    1 Blocks protein family: IPB000938 CAP-Gly domain

    UniProtKB/Swiss-Prot: CLIP2_HUMAN, Q9UDT6
    Similarity: Contains 2 CAP-Gly domains


    Function
    for CLIP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLIP2_HUMAN, Q9UDT6
    Function: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in
    bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of
    brain-specific organelle translocations (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIP2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP2 (see all 28):
    hsa-miR-644 hsa-miR-125a-5p hsa-miR-4254 hsa-miR-429 hsa-miR-520d-5p hsa-miR-411 hsa-miR-200a hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CLIP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CLIP2

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding ----
    GO:0051010microtubule plus-end binding ----


    CLIP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLIP2:
     Decreased homologous recombina 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Clip2):
     behavior/neurological  cellular  growth/size  nervous system  normal 
     skeleton 

    CLIP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLIP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLIP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for CLIP2 (Q9UDT63 ENSP000002233984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLASP1Q7Z4603, ENSP000002637104I2D: score=3 STRING: ENSP00000263710
    MAXP612443, ENSP000003514904I2D: score=3 STRING: ENSP00000351490
    CLASP2O751223, ENSP000003525814I2D: score=3 STRING: ENSP00000352581
    DYNLL1P631673I2D: score=3 
    YWHABP319463I2D: score=1 
    About this table

    Drugs & Compounds
    for CLIP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIP2
    Search CenterWatch for drugs/clinical trials and news about CLIP2 

    Transcripts
    for CLIP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLIP2 gene (2 alternative transcripts): 
    NM_003388.4  NM_032421.2  

    Unigene Cluster for CLIP2:

    CAP-GLY domain containing linker protein 2
    Hs.647018  [show with all ESTs]
    Unigene Representative Sequence: NM_003388
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361545 ENST00000395060(uc003uao.3) ENST00000487091 ENST00000493166
    ENST00000482424 ENST00000491075 ENST00000474962 ENST00000487447 ENST00000223398(uc003uam.3 uc003uan.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP2 (see all 28):
    hsa-miR-644 hsa-miR-125a-5p hsa-miR-4254 hsa-miR-429 hsa-miR-520d-5p hsa-miR-411 hsa-miR-200a hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CLIP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIP2 (see all 7)
    OriGene shRNA RFP: CLIP2
    OriGene siRNA: CLIP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIP2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB006629.2 AK095186.1 AY295764.1 AY927468.1 AY927469.1 AY927482.1 AY927584.1 BC006259.2 
    BC150332.1 

    6 DOTS entries:

    DT.315891  DT.95370679  DT.100707389  DT.121121335  DT.99999520  DT.100783968 

    24/176 AceView cDNA sequences (see all 176):

    AA402198 AI638716 BX279666 NM_003388 BQ945124 AW024344 AI151132 W73173 
    CR600159 AI655957 NM_032421 CD674891 AW002459 AW590662 AY295764 CB156486 
    BM793042 BE552298 AW027862 AB006629 AI204077 BF932343 BX281179 BU624521 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLIP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                  -                                                               
    SP2:                                                                                                                  
    SP3:                                                                                                        -         


    ECgene alternative splicing isoforms for CLIP2

    Expression
    for CLIP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCCCTCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLIP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See CLIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIP2

    SOURCE GeneReport for Unigene cluster: Hs.647018
        SABiosciences Expression via Pathway-Focused PCR Array including CLIP2: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CLIP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CLIP2 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLIP21 CAP-GLY domain containing linker protein 2 76.58(n)
    78.82(a)    		   417488  XM_415736.3  XP_415736.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CLIP26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343889.1(64283-97855)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.143482 Transcribed sequence with weak similarity to protein more 77.09(n)    BG738732.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CLIP-1906
    		 Cytoplasmic linker protein 190
    		 13(a)
    		 1 → many
    		 2L(17384700-17409698)


    ENSEMBL Gene Tree for CLIP2 (if available)
    TreeFam Gene Tree for CLIP2 (if available) 

    Paralogs
    for CLIP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIP2 gene
    CEP3502  CLIP32  TBCB2  CLIP42  CLIP12  DCTN12  ENSG000002643242  
    2 SIMAP similar genes for CLIP2 using alignment to 4 protein entries:     CLIP2_HUMAN (see all proteins):
    CYLN2    CLIP1

    CLIP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CLIP2
    PGOHUM00000240497


    Genomic Variants
    for CLIP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2135 NCBI SNPs in CLIP2 are shown (see all 2135)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs715585261,2
    		C,--73036559(+) CACCAG/CCAGGT 2 -- us2k11Minor allele frequency- C:0.50NA 2
    rs287050901,2
    		C,F,--73037909(+) GCACTG/CCCACG 2 -- int14Minor allele frequency- C:0.30WA CSA NA 242
    rs1128375481,2
    		C,--73038198(+) AGCCC-/TTCA  
                TTCAT     		2 -- int11Minor allele frequency- TTCA:0.50CSA 2
    rs39011061,2
    		C,H--73038232(-) CCCTAG/AAAGTG 2 -- int13Minor allele frequency- A:0.01NS NA 120
    rs38990671,2
    		H,--73038418(-) TGCACG/AAAACC 2 -- int14Minor allele frequency- A:0.00NS EA 418
    rs39008431,2
    		H--73038462(-) agcctC/Tctttt 2 -- int1 trp34Minor allele frequency- T:0.00NS EA 418
    rs715585271,2
    		C,--73038792(+) CTTTCT/CGGCAT 2 -- int12Minor allele frequency- C:0.25NA 4
    rs803136281,2
    		C,F,--73040270(+) CCCACC/GCTCTT 2 -- int11Minor allele frequency- G:0.04WA 118
    rs749406771,2
    		F,--73040354(+) AAACAC/TGCTAT 2 -- int11Minor allele frequency- T:0.06WA 118
    rs1146808471,2
    		C,F,--73040542(+) GCCCTC/TCGATC 2 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for CLIP2 (73703805 - 73820273 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CLIP2
         1 CNV: 4543

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIP2

    Disorders / Diseases
    for CLIP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLIP2 for disorders           About GeneDecksing

    OMIM gene information: 603432    OMIM disorders: --

    UniProtKB/Swiss-Prot: CLIP2_HUMAN, Q9UDT6
  • Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous
    • deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between
    highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause
    of certain cardiovascular and musculo-skeletal abnormalities observed in the disease

    9 diseases for CLIP2:    About MalaCards
    williams-beuren syndrome    williams syndrome    charcot-marie-tooth disease    distal hereditary motor neuropathy
    tooth disease    neuropathy    thyroiditis    hepatitis
    neuronitis

    1 Novoseek disease relationship for CLIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    williams syndrome 85.5 3 14745832 (2), 12195424 (1)

    Human Genome Epidemiology (HuGE) Navigator: CLIP2 (2 documents)

    Export disorders for CLIP2 gene to outside databases

    Publications
    for CLIP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIP2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CLIP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. (PubMed id 9799601)1, 2, 3, 9 Hoogenraad C.C....Galjart N. (1998)
    2. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. (PubMed id 8812460)1, 2, 3 Osborne L.R....Tsui L.C. (1996)
    3. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. (PubMed id 11290329)1, 2, 9 Akhmanova A....Galjart N. (2001)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
    7. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. (PubMed id 12195424)1, 9 Hoogenraad C.C....Galjart N. (2002)
    8. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    9. The contribution of CLIP2 haploinsufficiency to the cl inical manifestations of the Williams-Beuren syndrome. (PubMed id 22608712)1 Vandeweyer G....Kooy R.F. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for CLIP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CLIP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7461 HGNC: 2586 AceView: CYLN2 Ensembl:ENSG00000106665 euGenes: HUgn7461
    ECgene: CLIP2 H-InvDB: CLIP2

    Other Databases showing CLIP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0291

    Specialized Databases showing CLIP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLIP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLIP2 gene:
    Search GeneIP for patents involving CLIP2

    GeneCards and IP:
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