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Aliases for CLIP2 Gene

Aliases for CLIP2 Gene

  • CAP-GLY Domain Containing Linker Protein 2 2 3
  • WBSCR4 3 4 6
  • CYLN2 3 4 6
  • WSCR4 3 4 6
  • Williams-Beuren Syndrome Chromosomal Region 3 Protein 3 4
  • Williams-Beuren Syndrome Chromosomal Region 4 Protein 3 4
  • Williams-Beuren Syndrome Chromosome Region 3 2 3
  • Cytoplasmic Linker Protein 115 3 4
  • Cytoplasmic Linker Protein 2 3 4
  • Cytoplasmic Linker 2 2 3
  • CLIP-115 3 4
  • WBSCR3 3 4
  • Williams-Beuren Syndrome Chromosome Region 4 3
  • CAP-Gly Domain-Containing Linker Protein 2 3
  • KIAA0291 4
  • WSCR3 3
  • CLIP 3

External Ids for CLIP2 Gene

Previous HGNC Symbols for CLIP2 Gene

  • WBSCR4
  • CYLN2
  • WBSCR3

Previous GeneCards Identifiers for CLIP2 Gene

  • GC07P073342
  • GC07P073703
  • GC07P069585

Summaries for CLIP2 Gene

Entrez Gene Summary for CLIP2 Gene

  • The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIP2 Gene

CLIP2 (CAP-GLY Domain Containing Linker Protein 2) is a Protein Coding gene. Diseases associated with CLIP2 include williams-beuren syndrome. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for CLIP2 Gene

  • Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).

Gene Wiki entry for CLIP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIP2 Gene

Genomics for CLIP2 Gene

Regulatory Elements for CLIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLIP2 Gene

Start:
74,289,475 bp from pter
End:
74,405,943 bp from pter
Size:
116,469 bases
Orientation:
Plus strand

Genomic View for CLIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP2 Gene

Proteins for CLIP2 Gene

  • Protein details for CLIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDT6-CLIP2_HUMAN
    Recommended name:
    CAP-Gly domain-containing linker protein 2
    Protein Accession:
    Q9UDT6
    Secondary Accessions:
    • O14527
    • O43611

    Protein attributes for CLIP2 Gene

    Size:
    1046 amino acids
    Molecular mass:
    115837 Da
    Quaternary structure:
    • Interacts with CLASP1 and CLASP2.
    SequenceCaution:
    • Sequence=BAA22960.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLIP2 Gene

    Alternative splice isoforms for CLIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIP2 Gene

Proteomics data for CLIP2 Gene at MOPED

Post-translational modifications for CLIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLIP2 Gene

Antibody Products

No data available for DME Specific Peptides for CLIP2 Gene

Domains for CLIP2 Gene

Protein Domains for CLIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CLIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDT6

UniProtKB/Swiss-Prot:

CLIP2_HUMAN :
  • Q9UDT6
Domain:
  • Contains 2 CAP-Gly domains.
genes like me logo Genes that share domains with CLIP2: view

No data available for Gene Families for CLIP2 Gene

Function for CLIP2 Gene

Molecular function for CLIP2 Gene

UniProtKB/Swiss-Prot Function:
Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).

Gene Ontology (GO) - Molecular Function for CLIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051010 microtubule plus-end binding IEA --
genes like me logo Genes that share ontologies with CLIP2: view
genes like me logo Genes that share phenotypes with CLIP2: view

Animal Model Products

miRNA for CLIP2 Gene

miRTarBase miRNAs that target CLIP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLIP2 Gene

Localization for CLIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIP2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIP2 Gene COMPARTMENTS Subcellular localization image for CLIP2 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CLIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005875 microtubule associated complex TAS 9799601
GO:0005881 cytoplasmic microtubule IEA --
GO:0016020 membrane --
GO:0035371 microtubule plus-end IEA --
genes like me logo Genes that share ontologies with CLIP2: view

Pathways for CLIP2 Gene

SuperPathways for CLIP2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CLIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with CLIP2: view

No data available for Pathways by source for CLIP2 Gene

Transcripts for CLIP2 Gene

Unigene Clusters for CLIP2 Gene

CAP-GLY domain containing linker protein 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2:
SP3: -

Relevant External Links for CLIP2 Gene

GeneLoc Exon Structure for
CLIP2
ECgene alternative splicing isoforms for
CLIP2

Expression for CLIP2 Gene

mRNA expression in normal human tissues for CLIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CLIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.7), Brain (10.8), Fetal Brain (10.1), Heart (9.3), and Frontal cortex (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIP2 Gene

SOURCE GeneReport for Unigene cluster for CLIP2 Gene Hs.647018

genes like me logo Genes that share expressions with CLIP2: view

Expression partners for CLIP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CLIP2 Gene

Orthologs for CLIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLIP2 35
  • 90.77 (n)
  • 93.77 (a)
CLIP2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIP2 35
  • 88.12 (n)
  • 91.93 (a)
CLIP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clip2 35
  • 85.95 (n)
  • 91.78 (a)
Clip2 16
Clip2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLIP2 35
  • 99.43 (n)
  • 99.71 (a)
CLIP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clip2 35
  • 85.26 (n)
  • 91.39 (a)
oppossum
(Monodelphis domestica)
Mammalia CLIP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIP2 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLIP2 35
  • 76.42 (n)
  • 78.58 (a)
CLIP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIP2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clip2 35
  • 66.8 (n)
  • 73.09 (a)
zebrafish
(Danio rerio)
Actinopterygii clip2 35
  • 66.73 (n)
  • 65.3 (a)
Dr.14348 35
clip2 36
  • 63 (a)
OneToOne
Species with no ortholog for CLIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP2 Gene

ENSEMBL:
Gene Tree for CLIP2 (if available)
TreeFam:
Gene Tree for CLIP2 (if available)

Paralogs for CLIP2 Gene

Paralogs for CLIP2 Gene

Selected SIMAP similar genes for CLIP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CLIP2 Gene

genes like me logo Genes that share paralogs with CLIP2: view

Variants for CLIP2 Gene

Sequence variations from dbSNP and Humsavar for CLIP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs5874 -- 74,405,694(+) TCTAG(C/G)AGGGT utr-variant-3-prime
rs229868 -- 74,322,263(-) ctgta(A/C)tccca intron-variant
rs229869 -- 74,321,265(-) TAATG(A/G)ACGTT intron-variant
rs229870 -- 74,320,212(-) tcttt(C/T)ttttt intron-variant
rs229871 -- 74,318,598(-) GTAGC(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIP2 Gene

Variant ID Type Subtype PubMed ID
nsv831031 CNV Loss 17160897
esv2661080 CNV Deletion 23128226
nsv831032 CNV Loss 17160897
esv2667384 CNV Deletion 23128226
esv2734668 CNV Deletion 23290073
nsv5793 CNV Loss 18451855

Relevant External Links for CLIP2 Gene

HapMap Linkage Disequilibrium report
CLIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP2 Gene

Disorders for CLIP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CLIP2 Gene in MalaCards »

(1) Diseases for CLIP2 Gene including...

UniProtKB/Swiss-Prot

CLIP2_HUMAN
  • Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

(1) Novoseek inferred disease relationships for CLIP2 Gene

Disease -log(P) Hits PubMed IDs
williams syndrome 85.5 3

Relevant External Links for CLIP2

Genetic Association Database (GAD)
CLIP2
Human Genome Epidemiology (HuGE) Navigator
CLIP2
genes like me logo Genes that share disorders with CLIP2: view

No data available for OMIM , University of Copenhagen DISEASES and Genatlas for CLIP2 Gene

Publications for CLIP2 Gene

  1. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. (PMID: 9799601) Hoogenraad C.C. … Galjart N. (Genomics 1998) 2 3 4 23
  2. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. (PMID: 11290329) Akhmanova A. … Galjart N. (Cell 2001) 3 4 23
  3. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. (PMID: 8812460) Osborne L.R. … Tsui L.-C. (Genomics 1996) 2 3 4
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  5. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. (PMID: 12195424) Hoogenraad C.C. … Galjart N. (Nat. Genet. 2002) 3 23

Products for CLIP2 Gene

Sources for CLIP2 Gene

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