Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIP1 Gene

protein-coding   GIFtS: 56
GCID: GC12M122755

CAP-GLY Domain Containing Linker Protein 1

(Previous name: restin (Reed-Steinberg cell-expressed intermediate filament-associated...)
(Previous symbol: RSN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CAP-GLY Domain Containing Linker Protein 11 2     restin1
RSN1 2 3 5     CLIP2
Restin (Reed-Steinberg Cell-Expressed Intermediate Filament-Associated
Protein)1 2
     CLIP1702
Cytoplasmic Linker Protein 12 3     CAP-Gly Domain-Containing Linker Protein 12
Cytoplasmic Linker Protein 170 Alpha-22 3     Cytoplasmic Linker Protein CLIP-1702
CLIP-1702 3     Restin3
CYLN12 3     Reed-Sternberg Intermediate Filament-Associated Protein3

External Ids:    HGNC: 104611   Entrez Gene: 62492   Ensembl: ENSG000001307797   OMIM: 1798385   UniProtKB: P306223   

Export aliases for CLIP1 gene to outside databases

Previous GC identifers: GC12M121322 GC12M121205 GC12M119716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIP1 Gene:
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in
Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for CLIP1 Gene: 
CLIP1 (CAP-GLY domain containing linker protein 1) is a protein-coding gene. Diseases associated with CLIP1 include distal hereditary motor neuropathy, type ii, and distal hereditary motor neuropathy, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include microtubule binding and protein homodimerization activity. An important paralog of this gene is CLIP2.

UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby
plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome
trafficking

Gene Wiki entry for CLIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIP1 gene promoter:
         RFX1   FOXF2   HOXA3   AML1a   p53   YY1   Nkx6-1   NF-kappaB1   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.3

CLIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122755:  view genomic region     (about GC identifiers)

Start:
122,755,979 bp from pter      End:
122,907,179 bp from pter
Size:
151,201 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622 (See protein sequence)
Recommended Name: CAP-Gly domain-containing linker protein 1  
Size: 1438 amino acids; 162246 Da
Subunit: Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin.
Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane
protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus
ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of
intermediate macropinocytic vesicles
6/9 PDB 3D structures from and Proteopedia for CLIP1 (see all 9):
2CP5 (3D)        2CP6 (3D)        2E3H (3D)        2E3I (3D)        2E4H (3D)        2HQH (3D)    
Secondary accessions: A0AVD3 Q17RS4 Q29RG0
Alternative splicing: 3 isoforms:  P30622-3   P30622-1   P30622-2   

Explore the universe of human proteins at neXtProt for CLIP1: NX_P30622

Explore proteomics data for CLIP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30622

  • CLIP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLIP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001234926.1  NP_002947.1  NP_937883.1  

    ENSEMBL proteins: 
     ENSP00000355314   ENSP00000438743   ENSP00000303585   ENSP00000445531   ENSP00000437617  
     ENSP00000439093   ENSP00000437786   ENSP00000441409   ENSP00000446379   ENSP00000439472  
     ENSP00000445387   ENSP00000351665  
    Reactome Protein details: P30622
    Human Recombinant Protein Products for CLIP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CLIP1
    GenScript Custom Purified and Recombinant Proteins Services for CLIP1
    Novus Biologicals CLIP1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore TAS15928712
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome TAS1356075
    GO:0005813centrosome IDA--

    CLIP1 for ontologies           About GeneDecksing



    CLIP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CLIP1  (restin)
    OriGene Antibodies for CLIP1
    OriGene Custom Antibody Services for CLIP1
    GenScript Custom Superior Antibodies Services for CLIP1
    Novus Biologicals CLIP1 Antibodies
    Abcam antibodies for CLIP1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CLIP1
    LSBio Antibodies in human, mouse, rat for CLIP1 

    Assay Products for CLIP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLIP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLIP1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000938 CAP-Gly_domain
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry P30622

    ProtoNet protein and cluster: P30622

    2 Blocks protein domains:
    IPB000938 CAP-Gly domain
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
    Domain: Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction
    with tubulin
    Similarity: Contains 2 CAP-Gly domains
    Similarity: Contains 1 CCHC-type zinc finger


    CLIP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIP1_HUMAN, P30622
    Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
    Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby
    plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome
    trafficking

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI11940666
    GO:0008017microtubule binding IDA17889670
    GO:0008270zinc ion binding IDA17828275
    GO:0015631tubulin binding IDA17889670
         
    CLIP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clip1):
     cellular  reproductive system 

    CLIP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clip1tm1Gal for CLIP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLIP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLIP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLIP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLIP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIP1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP1 (see all 25):
    hsa-miR-429 hsa-miR-181c hsa-miR-301a hsa-miR-103a hsa-miR-199b-5p hsa-miR-200b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidCLIP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CLIP1
    Sirion Biotech Customized adenovirus for overexpression of CLIP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CLIP1 (see all 9)
    OriGene ORF clones in mouse, rat for CLIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLIP1 (NM_002956)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIP1
    Sirion Biotech Customized lentivirus for stable overexpression of CLIP1 
                         Customized lentivirus expression plasmids for stable overexpression of CLIP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CLIP1
    Search LifeMap BioReagents cell lines for CLIP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLIP1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4mTOR signaling pathway
    mTOR signaling pathway
    5Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CLIP1
        Cytoskeletal Signaling

    3 BioSystems Pathways for CLIP1
        mTOR signaling pathway
    Lissencephaly gene (LIS1) in neuronal migration and development
    Regulation of Microtubule Cytoskeleton

    5/9        Reactome Pathways for CLIP1 (see all 9)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    CLIP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for CLIP1 (P306222, 3 ENSP000003516654) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232960P678702, 3, ENSP000003955464MINT-8058217 I2D: score=1 STRING: ENSP00000395546
    CSNK2BP678702, 3MINT-8058217 I2D: score=1 
    ENSG00000206406P678702, 3MINT-8058217 I2D: score=1 
    ENSG00000224398P678702, 3MINT-8058217 I2D: score=1 
    ENSG00000224774P678702, 3MINT-8058217 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0001578microtubule bundle formation IMP17889670
    GO:0006810transport IEA--
    GO:0007067mitosis TAS15928712
    GO:0031116positive regulation of microtubule polymerization IMP15262990

    CLIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIP1

    7 Novoseek inferred chemical compound relationships for CLIP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 62.5 2 16608875 (1), 15262990 (1)
    gtp 23.1 2 16120651 (1)
    ionomycin 16.6 1 10620705 (1)
    thapsigargin 13 1 10620705 (1)
    calcium 0 2 16369480 (2)
    zinc 0 6 17563362 (2), 11940666 (2), 17828277 (1)
    hydrogen 0 1 7667280 (1)

    Search CenterWatch for drugs/clinical trials and news about CLIP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLIP1 gene (3 alternative transcripts): 
    NM_001247997.1  NM_002956.2  NM_198240.1  

    Unigene Cluster for CLIP1:

    CAP-GLY domain containing linker protein 1
    Hs.524809  [show with all ESTs]
    Unigene Representative Sequence: NM_001247997
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361654 ENST00000545889(uc001ucf.1) ENST00000302528 ENST00000537178
    ENST00000501271 ENST00000536634 ENST00000540539 ENST00000538120 ENST00000540338(uc001ucj.1 uc009zxo.1)
    ENST00000543205 ENST00000540304 ENST00000514271 ENST00000541410 ENST00000537004(uc010tae.2)
    ENST00000541108 ENST00000535290 ENST00000539080 ENST00000358808(uc001ucg.2 uc001uch.1 uc001uci.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIP1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP1 (see all 25):
    hsa-miR-429 hsa-miR-181c hsa-miR-301a hsa-miR-103a hsa-miR-199b-5p hsa-miR-200b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidCLIP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIP1
    Clone
    Products:
         
    OriGene clones in human, mouse for CLIP1 (see all 9)
    OriGene ORF clones in mouse, rat for CLIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CLIP1 (NM_002956)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIP1
    Sirion Biotech Customized lentivirus for stable overexpression of CLIP1 
                         Customized lentivirus expression plasmids for stable overexpression of CLIP1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLIP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIP1

    Additional mRNA sequence: 

    AB209115.1 AF045652.1 AF045653.1 AK126990.1 AY563000.1 BC047895.1 BC062543.1 BC114213.1 
    BC117209.1 BC126305.1 M97501.1 X64838.1 

    21 DOTS entries:

    DT.217772  DT.101983195  DT.99941429  DT.95371234  DT.97822056  DT.95371227  DT.92068744  DT.95305617 
    DT.121159268  DT.121159305  DT.304362  DT.97845116  DT.100788755  DT.91749921  DT.100788754  DT.86841094 
    DT.91885310  DT.95156652  DT.99975989  DT.91721355  DT.92012465 

    24/283 AceView cDNA sequences (see all 283):

    BM856968 BP364071 AL713517 AW950046 BP338469 BM998166 CA432835 AW237150 
    BM980141 AW270831 BC047895 AA835464 BX646973 H19025 BX382210 AL596826 
    NM_002956 BU784341 AI654225 AW205730 AI583719 BQ278921 BU788009 BG055016 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLIP1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                                -           -                 -                                                                             -               
    SP2:                                -           -                 -     -                                                                       -               
    SP3:                                -     -     -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
    SP1:              -                       -     -                                       
    SP2:              -                       -     -                                       
    SP3:                                                                                    
    SP4:                                      -     -     -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CLIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIP1 expression in normal human tissues (normalized intensities)      CLIP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGCAGTA
    CLIP1 Expression
    About this image


    CLIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             gastrocnemius muscle   
     
     Ovary (Reproductive System)
             oocyte   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             cerebellum   
     
     Thyroid (Endocrine System)

    See CLIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIP1

    SOURCE GeneReport for Unigene cluster: Hs.524809

    UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
    Tissue specificity: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells
    of Hodgkin disease

        SABiosciences Expression via Pathway-Focused PCR Array including CLIP1: 
              Cytoskeleton Regulators in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CLIP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CLIP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clip11 , 5 CAP-GLY domain containing linker protein 11, 5 87.11(n)1
    89.79(a)1
      5 (63.06 cM)5
    564301  NM_019765.41  NP_062739.21 
     1235777955 
    chicken
    (Gallus gallus)
    Aves CLIP11 CAP-GLY domain containing linker protein 1 75.74(n)
    74.68(a)
      395784  NM_204942.1  NP_990273.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLIP16
    --
    Uncharacterized protein
    70(a)
    16(a)
    1 ↔ 1
    possible ortholog
    GL343423.1(75273-176631)
    GL343333.1(1332463-1350074)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW646666.12   -- 77.79(n)    AW646666.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001479561 CAP-Gly domain-containing linker protein 1-like 56.74(n)
    50.28(a)
      100147956  XM_001920257.3  XP_001920292.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CLIP-1901 Cytoplasmic linker protein 190 42.88(n)
    30.32(a)
      35042  NM_135991.3  NP_609835.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALF16
    Alpha-tubulin folding protein, similar to mammalia...
    16(a)
    1 → many
    XIV(349907-350671)


    ENSEMBL Gene Tree for CLIP1 (if available)
    TreeFam Gene Tree for CLIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIP1 gene
    CLIP22  CEP3502  CLIP32  CLIP42  
    6 SIMAP similar genes for CLIP1 using alignment to 11 protein entries:     CLIP1_HUMAN (see all proteins):
    CLIP-170    RSN    CYLN2    TBCB    DCTN1    CLIP2

    CLIP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3258 SNPs in CLIP1 are shown (see all 3258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364464
    A breast cancer sample4--see VAR_0364462 M I mis40--------
    rs606134701,2
    C--119761220(+) TTTTT-/CTTTT/CTT
    TTT
    /CTTTTTT
    TTTTT
    6 -- int1 cds11NA 2
    rs3707412071,2
    C--119774160(+) TTTTG-/TTTT  
            
    GGGGG
    3 -- int10--------
    rs1432205531,2
    C--119808266(+) ATGAT-/AAAAAAAA 3 -- int10--------
    rs357296801,2
    C--119809955(+) AATAC-/TTTTTT 3 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs343142611,2
    C--119811226(+) AAAAAA/-GAAAG 3 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs762502891,2
    C--119818677(-) TTTTTA/TAAAAA 3 -- int10--------
    rs359478421,2
    C--119842883(+) GTTCA-/GGCGTG 3 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs1134447501,2
    C--119843523(+) AAAAC-/ACAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs2004844311,2
    C--119850248(+) GTCGG-/TCCATC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CLIP1 (122755979 - 122907179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLIP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv324e199CNV Deletion23128226
    esv2672169CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CLIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179838    OMIM disorders: --

    20/22 diseases for CLIP1 (see all 22):    About MalaCards
    distal hereditary motor neuropathy, type ii    distal hereditary motor neuropathy    renovascular hypertension    williams syndrome
    familial adenomatous polyposis    dermatomyositis    lissencephaly    type 1 diabetes mellitus
    neuropathy    type 1 diabetes    duodenitis    colon adenocarcinoma
    acute lymphoblastic leukemia    lymphoblastic leukemia    diabetes mellitus    hypertension
    rheumatoid arthritis    arthritis    leukemia    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CLIP1:
    Extratemporal epilepsy

    CLIP1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CLIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hla-do 91.3 3 9382849 (2), 16191436 (1)
    familial adenomatous polyposis 28.4 3 18560734 (1), 17085436 (1), 16355537 (1)
    hodgkin disease 14.3 2 9746762 (1), 8222754 (1)
    autoimmune diseases 0 1 16181341 (1)
    autoimmunity 0 2 9550430 (1), 11739539 (1)

    Genetic Association Database (GAD): CLIP1

    Export disorders for CLIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIP1 gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with CLIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (PubMed id 17563362)1, 2, 9 Mishima M....Hakoshima T. (2007)
    2. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PubMed id 12231510)1, 2, 9 Choi J.H....Zheng X.F. (2002)
    3. Structure-function relationship of CAP-Gly domains. (PubMed id 17828277)1, 2, 9 Weisbrich A.... Steinmetz M.O. (2007)
    4. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. (PubMed id 8222754)1, 3, 9 Hilliker C....Van den Berghe H. (1994)
    5. CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1. (PubMed id 17828275)1, 2 Hayashi I....Ikura M. (2007)
    6. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. (PubMed id 17889670)1, 2 Slep K.C. and Vale R.D. (2007)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. (PubMed id 12433698)1, 2 Sahin U....Pfreundschuh M. (2002)
    10. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. (PubMed id 1600942)1, 2 Bilbe G.... Shipman R. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6249 HGNC: 10461 AceView: RSN Ensembl:ENSG00000130779 euGenes: HUgn6249
    ECgene: CLIP1 H-InvDB: CLIP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLIP1 gene:
    Search GeneIP for patents involving CLIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CLIP1   OriGene RNAi products in human, mouse, rat for CLIP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CLIP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CLIP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CLIP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLIP1   OriGene Custom Protein Services for CLIP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLIP1
     QIAGEN SeqTarget long-range PCR primers for resequencing CLIP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIP1
     GenScript Custom Purified and Recombinant Proteins Services for CLIP1 GenScript cDNA clones with any tag delivered in your preferred vector for CLIP1
     GenScript Custom Assay Services for CLIP1 GenScript Custom Superior Antibodies Services for CLIP1
     GenScript Custom overexpressing Cell Line Services for CLIP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CLIP1  (restin)

     Regulatory tfbs in CLIP1 promoter
     Search Chromatin IP Primers for CLIP1
     RT2 qPCR Primer Assay in human, mouse, rat CLIP1
     GNC Network for CLIP1
     SABiosciences PCR Arrays including human, mouse, rat CLIP1
     Search Tocris compounds for CLIP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLIP1 antibodies
     CLIP1 proteins
     Antibodies for CLIP1
     See all of Abcam's Antibodies, Kits and Proteins for CLIP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CLIP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIP1
     SwitchGear 3'UTR luciferase reporter plasmids for CLIP1
     Browse SwitchGear Promoter luciferase reporter plasmids for CLIP1
     ThermoFisher Antibodies for CLIP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CLIP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLIP1
    Customized:
     lentivirus for stable overexpression of CLIP1
     lentivirus expression plasmids for stable overexpression of CLIP1
     adenovirus for overexpression of CLIP1
     LSBio Antibodies in human, mouse, rat for CLIP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CLIP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4