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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIP1 Gene

protein-coding   GIFtS: 54
GCID: GC12M122755

CAP-GLY domain containing linker protein 1

(Previous name: restin (Reed-Steinberg cell-expressed intermediate filament-associated...)
(Previous symbol: RSN)
 Explore 20 diseases affiliated with
CLIP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLIP1    

Aliases
for CLIP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CAP-GLY Domain Containing Linker Protein 11 2     Cytoplasmic Linker Protein 12 3
RSN1 2 3 5     Cytoplasmic Linker Protein 170 Alpha-22 3
CLIP-1701 2 3     CAP-Gly Domain-Containing Linker Protein 12
CYLN11 2 3     Cytoplasmic Linker Protein CLIP-1702
CLIP1 2     Restin3
CLIP1701 2     Reed-Sternberg Intermediate Filament-Associated Protein3
Restin (Reed-Steinberg Cell-Expressed Intermediate Filament-Associated Protein)1 2     

External Ids:    HGNC: 104611   Entrez Gene: 62492   Ensembl: ENSG000001307797   OMIM: 1798385   UniProtKB: P306223   

Export aliases for CLIP1 gene to outside databases

Previous GC identifers: GC12M121322 GC12M121205 GC12M119716


Summaries
for CLIP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLIP1:
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in
Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes
microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important
role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking

Gene Wiki entry for CLIP1


Genomic Views
for CLIP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIP1 gene promoter:
         RFX1   FOXF2   HOXA3   AML1a   p53   YY1   Nkx6-1   NF-kappaB1   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CLIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.3

CLIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122755:  view genomic region     (about GC identifiers)

Start:
 122,755,979 bp from pter      End:
 122,907,179 bp from pter
Size:
 151,201 bases      Orientation:
 minus strand

Proteins
for CLIP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622 (See protein sequence)
Recommended Name: CAP-Gly domain-containing linker protein 1  
Size: 1438 amino acids; 162246 Da
Subunit: Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin.
Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein;
Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of
microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate
macropinocytic vesicles
6/9 PDB 3D structures from and Proteopedia for CLIP1 (see all 9):
2CP5 (3D)        2CP6 (3D)        2E3H (3D)        2E3I (3D)        2E4H (3D)        2HQH (3D)    
Secondary accessions: A0AVD3 Q17RS4 Q29RG0
Alternative splicing: 3 isoforms:  P30622-3   P30622-1   P30622-2   

Explore the universe of human proteins at neXtProt for CLIP1: NX_P30622

Post-translational modifications:

  • Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30622

    • CLIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001234926.1  NP_002947.1  NP_937883.1  

    ENSEMBL proteins: 
     ENSP00000355314   ENSP00000438743   ENSP00000303585   ENSP00000445531   ENSP00000437617  
     ENSP00000439093   ENSP00000437786   ENSP00000441409   ENSP00000446379   ENSP00000439472  
     ENSP00000445387   ENSP00000351665  
    Reactome Protein details: P30622
    Human Recombinant Protein Products: 
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    Novus Biologicals CLIP1 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLIP1

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore TAS15928712
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome TAS1356075
    GO:0005813centrosome IDA--


    CLIP1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CLIP1

    Assay Products for CLIP1: 
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    Uscn ELISAs and CLIAs for CLIP1

    Protein Domains /
    Families
    for CLIP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLIP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000938 CAP-Gly_domain
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry P30622

    ProtoNet protein and cluster: P30622

    2 Blocks protein families:
    IPB000938 CAP-Gly domain
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
    Domain: Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with
    tubulin
    Similarity: Contains 2 CAP-Gly domains
    Similarity: Contains 1 CCHC-type zinc finger


    Function
    for CLIP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
    Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes
    microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important
    role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIP1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP1 (see all 25):
    hsa-miR-429 hsa-miR-181c hsa-miR-301a hsa-miR-103a hsa-miR-199b-5p hsa-miR-200b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: CLIP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLIP1

    Clone
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    Search LifeMap BioReagents cell lines for CLIP1

    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI17828275
    GO:0008017microtubule binding IDA17889670
    GO:0008270zinc ion binding IDA17828275
    GO:0015631tubulin binding IDA17889670


    CLIP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Clip1tm1Gal for CLIP1
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Clip1):
     cellular  reproductive system 

    CLIP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLIP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    4Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    5mTOR signaling pathway
    		mTOR signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CLIP1
        Cytoskeletal Signaling

    2 BioSystems Pathways for CLIP1 
        mTOR signaling pathway
    Lissencephaly gene (LIS1) in neuronal migration and development

    5/10        Reactome Pathways for CLIP1 (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    CLIP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for CLIP1 (P306222, 3 ENSP000003516654) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN1Q142032, 3, ENSP000003547914MINT-2738062 I2D: score=3 STRING: ENSP00000354791
    MAPRE1Q156912, 3, ENSP000003647214MINT-1781393 I2D: score=1 STRING: ENSP00000364721
    CSNK2BP678702, 3MINT-8058217 I2D: score=1 
    TUBA4AP683662, 3, ENSP000002484374MINT-1789920 MINT-1781370 MINT-1781342 I2D: score=1 STRING: ENSP00000248437
    NDC80O147772, 3, ENSP000002615974MINT-8077584 MINT-8058295 I2D: score=1 STRING: ENSP00000261597
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001578microtubule bundle formation IMP17889670
    GO:0006810transport IEA--


    CLIP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLIP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIP1
    7 Novoseek chemical compound relationships for CLIP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 62.5 2 16608875 (1), 15262990 (1)
    gtp 23.1 2 16120651 (1)
    ionomycin 16.6 1 10620705 (1)
    thapsigargin 13 1 10620705 (1)
    calcium 0 2 16369480 (2)
    zinc 0 6 17563362 (2), 11940666 (2), 17828277 (1)
    hydrogen 0 1 7667280 (1)

    Search CenterWatch for drugs/clinical trials and news about CLIP1 

    Transcripts
    for CLIP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLIP1 gene (3 alternative transcripts): 
    NM_001247997.1  NM_002956.2  NM_198240.1  

    Unigene Cluster for CLIP1:

    CAP-GLY domain containing linker protein 1
    Hs.524809  [show with all ESTs]
    Unigene Representative Sequence: NM_001247997
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361654 ENST00000545889(uc001ucf.1) ENST00000302528 ENST00000537178
    ENST00000501271 ENST00000536634 ENST00000540539 ENST00000538120 ENST00000540338(uc001ucj.1 uc009zxo.1)
    ENST00000543205 ENST00000540304 ENST00000514271 ENST00000541410 ENST00000537004(uc010tae.2)
    ENST00000541108 ENST00000535290 ENST00000539080 ENST00000358808(uc001ucg.2 uc001uch.1 uc001uci.1)


    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIP1 (see all 25):
    hsa-miR-429 hsa-miR-181c hsa-miR-301a hsa-miR-103a hsa-miR-199b-5p hsa-miR-200b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: CLIP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209115.1 AF045652.1 AF045653.1 AK126990.1 AY563000.1 BC047895.1 BC062543.1 BC114213.1 
    BC117209.1 BC126305.1 M97501.1 X64838.1 

    21 DOTS entries:

    DT.217772  DT.101983195  DT.99941429  DT.95371234  DT.97822056  DT.95371227  DT.92068744  DT.95305617 
    DT.121159268  DT.121159305  DT.304362  DT.97845116  DT.100788755  DT.91749921  DT.100788754  DT.86841094 
    DT.91885310  DT.95156652  DT.91721355  DT.92012465  DT.99975989 

    24/283 AceView cDNA sequences (see all 283):

    AI913555 AI583719 BM980141 AL713517 BX646973 CA432835 BQ278921 AW270831 
    BX477400 NM_002956 BG620550 AW237150 CK299834 BP338469 BU784341 AI654225 
    AW205730 CA314875 BQ082726 AW950046 BQ188354 AI952030 BF431741 BC047895 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLIP1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                                -           -                 -                                                                             -               
    SP2:                                -           -                 -     -                                                                       -               
    SP3:                                -     -     -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
    SP1:              -                       -     -                                       
    SP2:              -                       -     -                                       
    SP3:                                                                                    
    SP4:                                      -     -     -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CLIP1

    Expression
    for CLIP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAGCAGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLIP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CLIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIP1

    SOURCE GeneReport for Unigene cluster: Hs.524809

    UniProtKB/Swiss-Prot: CLIP1_HUMAN, P30622
    Tissue specificity: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of
    Hodgkin disease

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              Cytoskeleton Regulators in human mouse rat

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    Orthologs
    for CLIP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CLIP1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLIP11 CAP-GLY domain containing linker protein 1 75.74(n)
    74.68(a)    		   395784  NM_204942.1  NP_990273.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLIP16
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343423.1(77305-158800)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AW646666.12   -- 77.79(n)    AW646666.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001479561 CAP-Gly domain-containing linker protein 1-like 56.74(n)
    50.28(a)    		   100147956  XM_001920257.3  XP_001920292.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CLIP-1901 Cytoplasmic linker protein 190 42.88(n)
    30.32(a)    		   35042  NM_135991.3  NP_609835.2 


    ENSEMBL Gene Tree for CLIP1 (if available)
    TreeFam Gene Tree for CLIP1 (if available) 

    Paralogs
    for CLIP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIP1 gene
    CLIP22  CEP3502  CLIP32  TBCB2  CLIP42  DCTN12  ENSG000002643242  
    6 SIMAP similar genes for CLIP1 using alignment to 11 protein entries:     CLIP1_HUMAN (see all proteins):
    CLIP-170    RSN    CYLN2    TBCB    DCTN1    CLIP2

    CLIP1 for paralogs           About GeneDecksing



    Genomic Variants
    for CLIP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2629 NCBI SNPs in CLIP1 are shown (see all 2629)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs79729601,2
    		C,F,--119716523(+) aacacG/Agtgaa 3 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs108465441,2
    		A--119716588(+) atagtC/Ttcagc 3 -- ds50010--------
    rs619543771,2
    		C,--119716898(+) CCACAA/GAACAA 3 -- ds50015Minor allele frequency- G:0.09WA NA EA 362
    rs802133381,2
    		C,--119717362(+) TTTATA/GCTGGC 3 -- ut313Minor allele frequency- G:0.13WA NA 240
    rs1120523641,2
    		C,--119717394(+) GGATAA/CCTGCC 3 -- ut310--------
    rs2020568421,2
    		C--119717405(+) AGAGAA/GGGAAA 3 -- ut310--------
    rs283647581,2
    		--119717492(+) TGCAAA/TGCCAC 3 -- ut312Minor allele frequency- T:0.00MN EA 1252
    rs10468001,2
    		C--119717607(-) TTTGGG/AAAAAA 3 -- ut311Minor allele frequency- A:0.00NA 2
    rs1127009721,2
    		C,--119719404(+) TCATCG/ATGTTG 3 -- int11Minor allele frequency- A:0.50WA 2
    rs123725711,2
    		H,--119720304(+) acggtG/Accagg 3 -- int15Minor allele frequency- A:0.01NS EA NA 538

    HapMap Linkage Disequilibrium report for CLIP1 (122755979 - 122907179 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLIP1: --

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    Disorders / Diseases
    for CLIP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLIP1 for disorders           About GeneDecksing

    OMIM gene information: 179838    OMIM disorders: --

    20 diseases for CLIP1:    About MalaCards
    distal hereditary motor neuropathy    distal hereditary motor neuropathy, type ii    familial adenomatous polyposis    type 1 diabetes mellitus
    renovascular hypertension    diabetes mellitus    acute lymphoblastic leukemia    lymphoblastic leukemia
    polyposis    williams syndrome    neuropathy    rheumatoid arthritis
    dermatomyositis    duodenitis    hypertension    arthritis
    leukemia    breast cancer    cholesterol    neuronitis

    5 Novoseek disease relationships for CLIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hla-do 91.3 3 9382849 (2), 16191436 (1)
    familial adenomatous polyposis 28.4 3 18560734 (1), 17085436 (1), 16355537 (1)
    hodgkin disease 14.3 2 9746762 (1), 8222754 (1)
    autoimmune diseases 0 1 16181341 (1)
    autoimmunity 0 2 9550430 (1), 11739539 (1)


    Export disorders for CLIP1 gene to outside databases

    Publications
    for CLIP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIP1 gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with CLIP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (PubMed id 17563362)1, 2, 9 Mishima M....Hakoshima T. (2007)
    2. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PubMed id 12231510)1, 2, 9 Choi J.H....Zheng X.F. (2002)
    3. Structure-function relationship of CAP-Gly domains. (PubMed id 17828277)1, 2, 9 Weisbrich A.... Steinmetz M.O. (2007)
    4. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. (PubMed id 8222754)1, 3, 9 Hilliker C....Van den Berghe H. (1994)
    5. CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1. (PubMed id 17828275)1, 2 Hayashi I....Ikura M. (2007)
    6. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. (PubMed id 17889670)1, 2 Slep K.C. and Vale R.D. (2007)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells. (PubMed id 12433698)1, 2 Sahin U....Pfreundschuh M. (2002)
    10. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. (PubMed id 1600942)1, 2 Bilbe G.... Shipman R. (1992)

    External Searches for CLIP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing CLIP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6249 HGNC: 10461 AceView: RSN Ensembl:ENSG00000130779 euGenes: HUgn6249
    ECgene: CLIP1 H-InvDB: CLIP1

    Other Databases showing CLIP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLIP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLIP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLIP1 gene:
    Search GeneIP for patents involving CLIP1

    GeneCards and IP:
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