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Aliases for CLIP1 Gene

Aliases for CLIP1 Gene

  • CAP-GLY Domain Containing Linker Protein 1 2 3
  • RSN 3 4 6
  • Restin (Reed-Steinberg Cell-Expressed Intermediate Filament-Associated Protein) 2 3
  • Cytoplasmic Linker Protein 170 Alpha-2 3 4
  • Cytoplasmic Linker Protein 1 3 4
  • CLIP-170 3 4
  • Restin 2 4
  • CYLN1 3 4
  • Reed-Sternberg Intermediate Filament-Associated Protein 4
  • CAP-Gly Domain-Containing Linker Protein 1 3
  • Cytoplasmic Linker Protein CLIP-170 3
  • CLIP170 3
  • CLIP 3

External Ids for CLIP1 Gene

Previous HGNC Symbols for CLIP1 Gene

  • RSN

Previous GeneCards Identifiers for CLIP1 Gene

  • GC12M121322
  • GC12M121205
  • GC12M122755
  • GC12M119716

Summaries for CLIP1 Gene

Entrez Gene Summary for CLIP1 Gene

  • The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CLIP1 Gene

CLIP1 (CAP-GLY Domain Containing Linker Protein 1) is a Protein Coding gene. Diseases associated with CLIP1 include extratemporal epilepsy and autosomal recessive non-syndromic intellectual disability. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for CLIP1 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.

Gene Wiki entry for CLIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIP1 Gene

Genomics for CLIP1 Gene

Regulatory Elements for CLIP1 Gene

Genomic Location for CLIP1 Gene

Start:
122,271,432 bp from pter
End:
122,423,034 bp from pter
Size:
151,603 bases
Orientation:
Minus strand

Genomic View for CLIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP1 Gene

Proteins for CLIP1 Gene

  • Protein details for CLIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30622-CLIP1_HUMAN
    Recommended name:
    CAP-Gly domain-containing linker protein 1
    Protein Accession:
    P30622
    Secondary Accessions:
    • A0AVD3
    • Q17RS4
    • Q29RG0

    Protein attributes for CLIP1 Gene

    Size:
    1438 amino acids
    Molecular mass:
    162246 Da
    Quaternary structure:
    • Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3.

    Three dimensional structures from OCA and Proteopedia for CLIP1 Gene

    Alternative splice isoforms for CLIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIP1 Gene

Proteomics data for CLIP1 Gene at MOPED

Post-translational modifications for CLIP1 Gene

  • Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CLIP1 Gene

Domains for CLIP1 Gene

Protein Domains for CLIP1 Gene

Suggested Antigen Peptide Sequences for CLIP1 Gene

Graphical View of Domain Structure for InterPro Entry

P30622

UniProtKB/Swiss-Prot:

CLIP1_HUMAN :
  • P30622
Domain:
  • Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin
  • Contains 2 CAP-Gly domains.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with CLIP1: view

No data available for Gene Families for CLIP1 Gene

Function for CLIP1 Gene

Molecular function for CLIP1 Gene

UniProtKB/Swiss-Prot Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.

Gene Ontology (GO) - Molecular Function for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 11940666
GO:0008017 microtubule binding IDA 17889670
GO:0008270 zinc ion binding IDA 17828275
GO:0015631 tubulin binding IDA 17889670
genes like me logo Genes that share ontologies with CLIP1: view

Phenotypes for CLIP1 Gene

genes like me logo Genes that share phenotypes with CLIP1: view

Animal Models for CLIP1 Gene

MGI Knock Outs for CLIP1:

miRNA for CLIP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLIP1 Gene

Localization for CLIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIP1 Gene COMPARTMENTS Subcellular localization image for CLIP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
endosome 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore TAS 15928712
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome TAS 1356075
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CLIP1: view

Pathways for CLIP1 Gene

genes like me logo Genes that share pathways with CLIP1: view

Gene Ontology (GO) - Biological Process for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001578 microtubule bundle formation IMP 17889670
GO:0006810 transport --
GO:0007067 mitotic nuclear division TAS 15928712
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CLIP1: view

Compounds for CLIP1 Gene

(7) Novoseek inferred chemical compound relationships for CLIP1 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 62.5 2
gtp 23.1 1
ionomycin 16.6 1
thapsigargin 13 1
calcium 0 2
genes like me logo Genes that share compounds with CLIP1: view

Transcripts for CLIP1 Gene

Unigene Clusters for CLIP1 Gene

CAP-GLY domain containing linker protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
SP1: - - -
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLIP1 Gene

GeneLoc Exon Structure for
CLIP1
ECgene alternative splicing isoforms for
CLIP1

Expression for CLIP1 Gene

mRNA expression in normal human tissues for CLIP1 Gene

mRNA differential expression in normal tissues according to GTEx for CLIP1 Gene

This gene is overexpressed in Muscle - Skeletal (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIP1 Gene

SOURCE GeneReport for Unigene cluster for CLIP1 Gene Hs.524809

mRNA Expression by UniProt/SwissProt for CLIP1 Gene

P30622-CLIP1_HUMAN
Tissue specificity: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
genes like me logo Genes that share expressions with CLIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CLIP1 Gene

Orthologs for CLIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLIP1 35
  • 98.97 (n)
  • 98.99 (a)
CLIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLIP1 35
  • 89.39 (n)
  • 91.95 (a)
CLIP1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIP1 35
  • 89.7 (n)
  • 91.45 (a)
CLIP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clip1 35
  • 87.11 (n)
  • 89.79 (a)
Clip1 16
Clip1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLIP1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves CLIP1 35
  • 75.1 (n)
  • 74.04 (a)
CLIP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIP1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clip1 35
  • 63.72 (n)
  • 60.02 (a)
zebrafish
(Danio rerio)
Actinopterygii CLIP1 (2 of 2) 36
  • 60 (a)
OneToMany
clip1a 35
  • 55.52 (n)
  • 48.59 (a)
clip1a 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CLIP-190 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for CLIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP1 Gene

ENSEMBL:
Gene Tree for CLIP1 (if available)
TreeFam:
Gene Tree for CLIP1 (if available)

Paralogs for CLIP1 Gene

Paralogs for CLIP1 Gene

genes like me logo Genes that share paralogs with CLIP1: view

Variants for CLIP1 Gene

Sequence variations from dbSNP and Humsavar for CLIP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7388 -- 122,271,637(-) ACTTC(A/T)ATAAT utr-variant-3-prime
rs10270 -- 122,271,795(-) TAATT(C/T)TGGAT utr-variant-3-prime
rs10542 -- 122,271,753(-) TCAAA(G/T)CACCT utr-variant-3-prime
rs868181 -- 122,322,822(+) AGCAA(A/C)ATGTT intron-variant
rs882969 -- 122,338,861(-) GGTTC(C/G)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIP1 Gene

Variant ID Type Subtype PubMed ID
esv2672169 CNV Deletion 23128226
dgv324e199 CNV Deletion 23128226

Relevant External Links for CLIP1 Gene

HapMap Linkage Disequilibrium report
CLIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP1 Gene

Disorders for CLIP1 Gene

(1) University of Copenhagen DISEASES for CLIP1 Gene

(5) Novoseek inferred disease relationships for CLIP1 Gene

Disease -log(P) Hits PubMed IDs
hla-do 91.3 3
familial adenomatous polyposis 28.4 3
hodgkin disease 14.3 2
autoimmune diseases 0 1
autoimmunity 0 2

Relevant External Links for CLIP1

Genetic Association Database (GAD)
CLIP1
genes like me logo Genes that share disorders with CLIP1: view

No data available for UniProtKB/Swiss-Prot for CLIP1 Gene

Publications for CLIP1 Gene

  1. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. (PMID: 8222754) Hilliker C. … Van den Berghe H. (Cytogenet. Cell Genet. 1994) 2 3 23
  2. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PMID: 12231510) Choi J.H. … Zheng X.F. (EMBO Rep. 2002) 3 4 23
  3. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (PMID: 17563362) Mishima M. … Hakoshima T. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  4. Structure-function relationship of CAP-Gly domains. (PMID: 17828277) Weisbrich A. … Steinmetz M.O. (Nat. Struct. Mol. Biol. 2007) 3 4 23
  5. Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells. (PMID: 18237546) Suzuki K. … Takahashi K. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for CLIP1 Gene

Sources for CLIP1 Gene

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