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Aliases for CLINT1 Gene

Aliases for CLINT1 Gene

  • Clathrin Interactor 1 2 3
  • EPN4 3 4 6
  • EPNR 3 4 6
  • Epsin-Related Protein 3 4
  • Enthoprotin 3 4
  • KIAA0171 4 6
  • EpsinR 3 4
  • CLINT 3 4
  • ENTH 3 4
  • Clathrin Interacting Protein Localized In The Trans-Golgi Region 3
  • Clathrin-Interacting Protein Localized In The Trans-Golgi Region 4
  • Epsin 4 3
  • Epsin-4 4

External Ids for CLINT1 Gene

Previous GeneCards Identifiers for CLINT1 Gene

  • GC05M157146
  • GC05M152305
  • GC05M157212

Summaries for CLINT1 Gene

Entrez Gene Summary for CLINT1 Gene

  • This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for CLINT1 Gene

CLINT1 (Clathrin Interactor 1) is a Protein Coding gene. Diseases associated with CLINT1 include schizophrenia. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include lipid binding and clathrin binding. An important paralog of this gene is EPN3.

UniProtKB/Swiss-Prot for CLINT1 Gene

  • Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.

Gene Wiki entry for CLINT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLINT1 Gene

Genomics for CLINT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLINT1 Gene

Start:
157,785,743 bp from pter
End:
157,859,175 bp from pter
Size:
73,433 bases
Orientation:
Minus strand

Genomic View for CLINT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLINT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLINT1 Gene

Proteins for CLINT1 Gene

  • Protein details for CLINT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14677-EPN4_HUMAN
    Recommended name:
    Clathrin interactor 1
    Protein Accession:
    Q14677
    Secondary Accessions:
    • B7Z6F8
    • D3DQJ6
    • Q8NAF1
    • Q96E05

    Protein attributes for CLINT1 Gene

    Size:
    625 amino acids
    Molecular mass:
    68259 Da
    Quaternary structure:
    • Binds clathrin heavy chain, GGA2, AP-2 and AP1G1
    SequenceCaution:
    • Sequence=BAA11488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLINT1 Gene

    Alternative splice isoforms for CLINT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLINT1 Gene

Proteomics data for CLINT1 Gene at MOPED

Post-translational modifications for CLINT1 Gene

  • Ubiquitination at Lys158, Lys183, Lys200, Lys207, Lys218, Lys297, Lys314, Lys467, and Lys453
  • Modification sites at PhosphoSitePlus

Other Protein References for CLINT1 Gene

No data available for DME Specific Peptides for CLINT1 Gene

Domains for CLINT1 Gene

Protein Domains for CLINT1 Gene

Suggested Antigen Peptide Sequences for CLINT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14677

UniProtKB/Swiss-Prot:

EPN4_HUMAN :
  • Q14677
Domain:
  • Contains 1 ENTH (epsin N-terminal homology) domain.
Family:
  • Belongs to the epsin family.
genes like me logo Genes that share domains with CLINT1: view

No data available for Gene Families for CLINT1 Gene

Function for CLINT1 Gene

Molecular function for CLINT1 Gene

UniProtKB/Swiss-Prot Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.

Gene Ontology (GO) - Molecular Function for CLINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12429846
GO:0005543 phospholipid binding --
GO:0008289 lipid binding IEA --
GO:0030276 clathrin binding IPI 12429846
genes like me logo Genes that share ontologies with CLINT1: view

Phenotypes for CLINT1 Gene

GenomeRNAi human phenotypes for CLINT1:
genes like me logo Genes that share phenotypes with CLINT1: view

Animal Model Products

CRISPR Products

miRNA for CLINT1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLINT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLINT1 Gene

Localization for CLINT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLINT1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLINT1 Gene COMPARTMENTS Subcellular localization image for CLINT1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
nucleus 3
endosome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CLINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA 10942595
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CLINT1: view

Pathways for CLINT1 Gene

genes like me logo Genes that share pathways with CLINT1: view

Gene Ontology (GO) - Biological Process for CLINT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006897 endocytosis IEA --
GO:0048268 clathrin coat assembly IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with CLINT1: view

Compounds for CLINT1 Gene

(2) Novoseek inferred chemical compound relationships for CLINT1 Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 43.8 2
lipid 0 2
genes like me logo Genes that share compounds with CLINT1: view

Transcripts for CLINT1 Gene

Unigene Clusters for CLINT1 Gene

Clathrin interactor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLINT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLINT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: -
SP6:

Relevant External Links for CLINT1 Gene

GeneLoc Exon Structure for
CLINT1
ECgene alternative splicing isoforms for
CLINT1

Expression for CLINT1 Gene

mRNA expression in normal human tissues for CLINT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLINT1 Gene

SOURCE GeneReport for Unigene cluster for CLINT1 Gene Hs.644000

mRNA Expression by UniProt/SwissProt for CLINT1 Gene

Q14677-EPN4_HUMAN
Tissue specificity: Ubiquitously expressed at low to intermediate levels.
genes like me logo Genes that share expressions with CLINT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CLINT1 Gene

Orthologs for CLINT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLINT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLINT1 35
  • 99.67 (n)
  • 99.83 (a)
cow
(Bos Taurus)
Mammalia CLINT1 35
  • 95.8 (n)
  • 97.67 (a)
CLINT1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLINT1 35
  • 95.13 (n)
  • 97.51 (a)
CLINT1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clint1 35
  • 89.99 (n)
  • 94.7 (a)
Clint1 16
Clint1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLINT1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLINT1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clint1 35
  • 90.68 (n)
  • 96.94 (a)
chicken
(Gallus gallus)
Aves CLINT1 35
  • 81.8 (n)
  • 84.09 (a)
CLINT1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLINT1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1440 35
tropical clawed frog
(Silurana tropicalis)
Amphibia clint1 35
  • 71.14 (n)
  • 73.02 (a)
zebrafish
(Danio rerio)
Actinopterygii CLINT1 (2 of 2) 36
  • 56 (a)
OneToMany
clint1a 35
  • 66.18 (n)
  • 67.53 (a)
clint1a 36
  • 65 (a)
OneToMany
wufa05f05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004504 35
  • 48.41 (n)
  • 42.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta lqfR 35
  • 50.13 (n)
  • 48.22 (a)
lqfR 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsd-3 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENT3 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.952 36
  • 61 (a)
OneToOne
Species with no ortholog for CLINT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLINT1 Gene

ENSEMBL:
Gene Tree for CLINT1 (if available)
TreeFam:
Gene Tree for CLINT1 (if available)

Paralogs for CLINT1 Gene

Paralogs for CLINT1 Gene

genes like me logo Genes that share paralogs with CLINT1: view

Variants for CLINT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLINT1 Gene

Q14677-EPN4_HUMAN
Genetic variations in CLINT1 may contribute to susceptibility to schizophrenia and psychotic disorders in some populations

Sequence variations from dbSNP and Humsavar for CLINT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12283 -- 157,787,426(-) TTTCC(A/G)GTGAG utr-variant-3-prime
rs12284 -- 157,787,179(-) GATGA(C/T)CAGTT utr-variant-3-prime
rs166221 -- 157,791,313(-) tcgga(A/C/G/T)gctga intron-variant
rs168838 -- 157,837,417(-) TGTGT(A/G/T)TGTGT intron-variant
rs171712 -- 157,839,467(-) cctgc(C/T)accac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLINT1 Gene

Variant ID Type Subtype PubMed ID
dgv1868e1 CNV Complex 17122850
nsv509097 CNV Insertion 20534489
nsv521000 CNV Loss 19592680

Relevant External Links for CLINT1 Gene

HapMap Linkage Disequilibrium report
CLINT1

Disorders for CLINT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CLINT1 Gene including...

Search for CLINT1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLINT1 Gene

(1) Novoseek inferred disease relationships for CLINT1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 39.2 15

Relevant External Links for CLINT1

Genetic Association Database (GAD)
CLINT1
Human Genome Epidemiology (HuGE) Navigator
CLINT1
genes like me logo Genes that share disorders with CLINT1: view

No data available for UniProtKB/Swiss-Prot for CLINT1 Gene

Publications for CLINT1 Gene

  1. Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. (PMID: 12213833) Wasiak S. … McPherson P.S. (J. Cell Biol. 2002) 2 3 4 23
  2. The Epsin 4 gene on chromosome 5q, which encodes the clathrin- associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. (PMID: 15793701) Pimm J. … Gurling H. (Am. J. Hum. Genet. 2005) 3 4 23 48
  3. Family-based association study of Epsin 4 and Schizophrenia. (PMID: 16402136) Tang R.Q. … He L. (Mol. Psychiatry 2006) 3 23 48
  4. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. (PMID: 12538641) Mills I.G. … McMahon H.T. (J. Cell Biol. 2003) 3 4 23
  5. Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population. (PMID: 18696005) Richards M. … Kunugi H. (J Neural Transm 2008) 3 23 48

Products for CLINT1 Gene

Sources for CLINT1 Gene

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