Aliases for CLIC6 Gene
External Ids for CLIC6 Gene
Previous HGNC Symbols for CLIC6 Gene
Previous GeneCards Identifiers for CLIC6 Gene
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
GeneCards Summary for CLIC6 Gene
CLIC6 (Chloride Intracellular Channel 6) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and chloride channel activity. An important paralog of this gene is CLIC1.
UniProtKB/Swiss-Prot for CLIC6 Gene
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).