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Aliases for CLIC6 Gene

Aliases for CLIC6 Gene

  • Chloride Intracellular Channel 6 2 3 5
  • Parchorin 3 4
  • CLIC1L 3 4
  • Chloride Channel Form A 3

External Ids for CLIC6 Gene

Previous HGNC Symbols for CLIC6 Gene

  • CLIC1L

Previous GeneCards Identifiers for CLIC6 Gene

  • GC21P032657
  • GC21P034962
  • GC21P034963
  • GC21P036041
  • GC21P021520

Summaries for CLIC6 Gene

Entrez Gene Summary for CLIC6 Gene

  • This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

GeneCards Summary for CLIC6 Gene

CLIC6 (Chloride Intracellular Channel 6) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and chloride channel activity. An important paralog of this gene is CLIC1.

UniProtKB/Swiss-Prot for CLIC6 Gene

  • May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).

Gene Wiki entry for CLIC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC6 Gene

Genomics for CLIC6 Gene

Regulatory Elements for CLIC6 Gene

Enhancers for CLIC6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLIC6 on UCSC Golden Path with GeneCards custom track

Promoters for CLIC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLIC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLIC6 Gene

Chromosome:
21
Start:
34,669,292 bp from pter
End:
34,718,227 bp from pter
Size:
48,936 bases
Orientation:
Plus strand

Genomic View for CLIC6 Gene

Genes around CLIC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC6 Gene

Proteins for CLIC6 Gene

  • Protein details for CLIC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NY7-CLIC6_HUMAN
    Recommended name:
    Chloride intracellular channel protein 6
    Protein Accession:
    Q96NY7
    Secondary Accessions:
    • A8K0U8
    • Q8IX31

    Protein attributes for CLIC6 Gene

    Size:
    704 amino acids
    Molecular mass:
    73012 Da
    Quaternary structure:
    • Interacts with dopamine receptors DRD2, DRD3 and DRD4.
    SequenceCaution:
    • Sequence=BAC03959.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLIC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIC6 Gene

Proteomics data for CLIC6 Gene at MOPED

Post-translational modifications for CLIC6 Gene

Other Protein References for CLIC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLIC6 Gene

Domains & Families for CLIC6 Gene

Gene Families for CLIC6 Gene

Suggested Antigen Peptide Sequences for CLIC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NY7

UniProtKB/Swiss-Prot:

CLIC6_HUMAN :
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
  • Belongs to the chloride channel CLIC family.
Domain:
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC6: view

Function for CLIC6 Gene

Molecular function for CLIC6 Gene

UniProtKB/Swiss-Prot Function:
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).

Gene Ontology (GO) - Molecular Function for CLIC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 NOT glutathione transferase activity IBA --
GO:0005254 chloride channel activity IBA --
genes like me logo Genes that share ontologies with CLIC6: view

Phenotypes for CLIC6 Gene

genes like me logo Genes that share phenotypes with CLIC6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CLIC6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLIC6 Gene

Localization for CLIC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC6 Gene

Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIC6 Gene COMPARTMENTS Subcellular localization image for CLIC6 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLIC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CLIC6: view

Pathways & Interactions for CLIC6 Gene

genes like me logo Genes that share pathways with CLIC6: view

Pathways by source for CLIC6 Gene

Gene Ontology (GO) - Biological Process for CLIC6 Gene

None

No data available for SIGNOR curated interactions for CLIC6 Gene

Drugs & Compounds for CLIC6 Gene

(1) Additional Compounds for CLIC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with CLIC6: view

Transcripts for CLIC6 Gene

Unigene Clusters for CLIC6 Gene

Chloride intracellular channel 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for CLIC6 Gene

GeneLoc Exon Structure for
CLIC6
ECgene alternative splicing isoforms for
CLIC6

Expression for CLIC6 Gene

mRNA expression in normal human tissues for CLIC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIC6 Gene

This gene is overexpressed in Stomach (x18.4) and Minor Salivary Gland (x4.5).

Protein differential expression in normal tissues from HIPED for CLIC6 Gene

This gene is overexpressed in Lavage (28.8) and Nasal epithelium (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIC6 Gene



SOURCE GeneReport for Unigene cluster for CLIC6 Gene Hs.473695

mRNA Expression by UniProt/SwissProt for CLIC6 Gene

Q96NY7-CLIC6_HUMAN
Tissue specificity: Expressed in brain, placenta, pancreas and liver.
genes like me logo Genes that share expression patterns with CLIC6: view

Primer Products

No data available for Protein tissue co-expression partners for CLIC6 Gene

Orthologs for CLIC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLIC6 35
  • 77.98 (n)
  • 71.25 (a)
CLIC6 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIC6 35
  • 90.6 (n)
  • 98.24 (a)
CLIC6 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clic6 35
  • 74.14 (n)
  • 69.69 (a)
Clic6 16
Clic6 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLIC6 35
  • 97.97 (n)
  • 96.34 (a)
CLIC6 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clic6 35
  • 74.6 (n)
  • 71.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CLIC6 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIC6 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLIC6 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIC6 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CLIC6 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 23 (a)
ManyToMany
exl-1 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 46 (a)
OneToMany
Species with no ortholog for CLIC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLIC6 Gene

ENSEMBL:
Gene Tree for CLIC6 (if available)
TreeFam:
Gene Tree for CLIC6 (if available)

Paralogs for CLIC6 Gene

Paralogs for CLIC6 Gene

(5) SIMAP similar genes for CLIC6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLIC6: view

Variants for CLIC6 Gene

Sequence variations from dbSNP and Humsavar for CLIC6 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs3171439 - 34,709,480(+) TCTGG(A/G)TGGGG reference, missense
rs1075704 -- 34,691,175(+) TCAAG(G/T)TTAGC intron-variant
rs2275969 -- 34,709,714(+) GATGG(C/G)CTTCG intron-variant
rs1557271 -- 34,695,476(+) AGAGG(C/T)CATTA intron-variant
rs4816498 -- 34,700,507(+) tttat(A/T)aaaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC6 Gene

Variant ID Type Subtype PubMed ID
nsv3501 CNV Insertion 18451855
esv2670909 CNV Deletion 23128226
esv2723369 CNV Deletion 23290073
nsv828868 CNV Loss 20364138
dgv718n67 CNV Loss 20364138
esv993312 CNV Loss 20482838

Variation tolerance for CLIC6 Gene

Gene Damage Index Score: 11.28; 92.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLIC6 Gene

Human Gene Mutation Database (HGMD)
CLIC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC6 Gene

Disorders for CLIC6 Gene

Relevant External Links for CLIC6

Genetic Association Database (GAD)
CLIC6
Human Genome Epidemiology (HuGE) Navigator
CLIC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLIC6

No disorders were found for CLIC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIC6 Gene

Publications for CLIC6 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4 67
  2. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. (PMID: 14597386) Friedli M. … Reymond A. (Gene 2003) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic landscape of the human choroid-retinal pigment epithelial complex. (PMID: 25058583) Skeie J.M. … Mahajan V.B. (JAMA Ophthalmol 2014) 3
  5. Combined linkage analysis and exome sequencing identifies novel genes for familial goiter. (PMID: 23535966) Yan J. … Koizumi A. (J. Hum. Genet. 2013) 3

Products for CLIC6 Gene

Sources for CLIC6 Gene

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