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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC6 Gene

protein-coding   GIFtS: 54
GCID: GC21P036041

Chloride Intracellular Channel 6


(Previous symbol: CLIC1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chloride Intracellular Channel 61 2
CLIC1L1 2 3
Chloride Channel Form A2
Chloride Intracellular Channel Protein 62
parchorin2
Parchorin3

External Ids:    HGNC: 20651   Entrez Gene: 541022   Ensembl: ENSG000001592127   OMIM: 6153215   UniProtKB: Q96NY73   

Export aliases for CLIC6 gene to outside databases

Previous GC identifers: GC21P032657 GC21P034962 GC21P034963 GC21P021520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIC6 Gene:
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large
triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been
described, but its biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC6 Gene: 
CLIC6 (chloride intracellular channel 6) is a protein-coding gene. Diseases associated with CLIC6 include gout, and cholera, and among its related super-pathways are Activation of cAMP-Dependent PKA and MODY (Maturity-Onset Diabetes of Young). GO annotations related to this gene include protein homodimerization activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC3.

UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting
cells, possibly through the regulation of chloride ion transport (By similarity)

Gene Wiki entry for CLIC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC6 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   Sp1   Nkx3-1 v1   Egr-4   Nkx3-1 v2   AREB6   HOXA5   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.12

CLIC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC6 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P036041:  view genomic region     (about GC identifiers)

Start:
36,041,688 bp from pter      End:
36,090,525 bp from pter
Size:
48,838 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 6  
Size: 704 amino acids; 73012 Da
Subunit: Interacts with dopamine receptors DRD2, DRD3 and DRD4 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Single-pass membrane protein (By similarity).
Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane
(By similarity)
Sequence caution: Sequence=BAC03959.1; Type=Erroneous initiation;
Secondary accessions: A8K0U8 Q8IX31
Alternative splicing: 2 isoforms:  Q96NY7-1   Q96NY7-2   

Explore the universe of human proteins at neXtProt for CLIC6: NX_Q96NY7

Explore proteomics data for CLIC6 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NY7

  • CLIC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLIC6 Protein Expression
    REFSEQ proteins: NP_444507.1  
    ENSEMBL proteins: 
     ENSP00000353959   ENSP00000290332  

    Human Recombinant Protein Products for CLIC6: 
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for CLIC6
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLIC6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--

    CLIC6 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CLIC6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q96NY7

    ProtoNet protein and cluster: Q96NY7

    1 Blocks protein domain: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    CLIC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC6_HUMAN, Q96NY7
    Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting
    cells, possibly through the regulation of chloride ion transport (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0031749D2 dopamine receptor binding IEA--
    GO:0031750D3 dopamine receptor binding IEA--
    GO:0031751D4 dopamine receptor binding IEA--
         
    CLIC6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLIC6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLIC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLIC6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLIC6 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidCLIC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of CLIC6 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLIC6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC6
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CLIC6 (Q96NY73 ENSP000002903324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD4P219173, ENSP000001761834I2D: score=1 STRING: ENSP00000176183
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    DRD3P354623, ENSP000003731694I2D: score=2 STRING: ENSP00000373169
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport ----

    CLIC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIC6

    1 HMDB Compound for CLIC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    Search CenterWatch for drugs/clinical trials and news about CLIC6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLIC6 gene: 
    NM_053277.1  

    Unigene Cluster for CLIC6:

    Chloride intracellular channel 6
    Hs.473695  [show with all ESTs]
    Unigene Representative Sequence: AF448439
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360731(uc010gmt.1) ENST00000349499(uc002yuf.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidCLIC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CLIC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC6
    Clone
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    OriGene clones in human, mouse for CLIC6 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLIC6 (NM_053277)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6
    Sirion Biotech Customized lentivirus for stable overexpression of CLIC6 
                         Customized lentivirus expression plasmids for stable overexpression of CLIC6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CLIC6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIC6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC6

    Additional mRNA sequence: 

    AF308293.1 AF426169.1 AF448438.1 AF448439.1 AK092733.1 AK289663.1 BC040196.2 

    2 DOTS entries:

    DT.205930  DT.100743038 

    24/67 AceView cDNA sequences (see all 67):

    AF426169 BM720027 BU688348 BQ030250 CB243644 AI801947 AI687382 AW028852 
    AI252646 AI252624 AW168083 AA974724 NM_053277 AF448439 CA391466 AI687177 
    AF448438 CA425200 AI433909 AW182855 AI762875 AX747695 AI638295 BE669792 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -                           
    SP2:        -           -                           
    SP3:                                                


    ECgene alternative splicing isoforms for CLIC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC6 expression in normal human tissues (normalized intensities)      CLIC6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAATGATT
    CLIC6 Expression
    About this image


    CLIC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Epithelium
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
             bronchial epithelial cells   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             visceral organ/metanephros/renal cortex   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Mandibular Condyle
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Choroid Plexus (Uncategorized)    fully expand to see all 2 entries
             Human Choroid Plexus Fibroblasts (HCPF)   

    See CLIC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC6

    SOURCE GeneReport for Unigene cluster: Hs.473695

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Tissue specificity: Expressed in brain, placenta, pancreas and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC6 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic61 , 5 chloride intracellular channel 61, 5 70.35(n)1
    65.37(a)1
      16 (53.64 cM)5
    2091951  NM_172469.31  NP_766057.11 
     924857365 
    chicken
    (Gallus gallus)
    Aves CLIC61 chloride intracellular channel 6 78.8(n)
    91.67(a)
      427981  XM_425551.3  XP_425551.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC66
    Uncharacterized protein
    42(a)
    1 ↔ 1
    3(142300053-142342279)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1018271 zgc:101827 67.93(n)
    76.05(a)
      492513  NM_001007385.1  NP_001007386.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    26(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Chloride intracellular channel exc-4
    27(a)
    19(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465)
    I(14512663-14518719)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DHAR31 glutathione S-transferase DHAR3 49.1(n)
    32.26(a)
      831532  NM_121676.3  NP_568336.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02326001 hypothetical protein 45.74(n)
    29.79(a)
      4340581  NM_001063763.1  NP_001057228.1 


    ENSEMBL Gene Tree for CLIC6 (if available)
    TreeFam Gene Tree for CLIC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC6 gene
    CLIC32  CLIC12  CLIC52  CLIC22  CLIC42  
    5 SIMAP similar genes for CLIC6 using alignment to 1 protein entry:     CLIC6_HUMAN:
    CLIC4    CLIC5    CLIC1    CLIC2    CLIC3

    CLIC6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1244 SNPs in CLIC6 are shown (see all 1244)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348769631,2
    C,F--36039689(+) AAAGGC/TTTGAA 1 -- us2k10--------
    rs72806631,2
    C,F,H--36039707(+) ggaggT/Cgaacc 1 -- us2k16Minor allele frequency- C:0.05NS EA CSA WA 540
    rs1422320241,2
    --36039708(+) GAGGTA/GAACCT 1 -- us2k10--------
    rs1511341981,2
    --36039721(+) ACTGGA/GGGTGG 1 -- us2k10--------
    rs713243181,2
    C,F--36039774(+) GATGCCTAT/-  
            
    CCTGT
    1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1464518881,2
    C--36039775(+) ATGCC-/CTAT  
            
    TGTCT
    1 -- us2k10--------
    rs106486871,2
    C--36039776(+) TGCCT-/ATCT  
            
    GTCTT
    1 -- us2k10--------
    rs1133700311,2
    C--36039777(+) TGCCTA/GTCTTA 1 -- us2k10--------
    rs173996611,2
    C,F--36039837(+) TAATAT/CACAGT 1 -- us2k1 tfbs33Minor allele frequency- C:0.01NA 136
    rs72808451,2
    C,H--36039870(+) aacaaT/Ctctgt 1 -- us2k15Minor allele frequency- C:0.00NS EA CSA 418

    HapMap Linkage Disequilibrium report for CLIC6 (36041688 - 36090525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLIC6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670909CNV Deletion23128226
    esv2723369CNV Deletion23290073
    nsv3501CNV Insertion18451855
    esv993312CNV Loss20482838
    nsv828868CNV Loss20364138
    dgv718n67CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615321    OMIM disorders: --

    4 diseases for CLIC6:    About MalaCards
    gout    cholera    breast cancer    hepatitis


    CLIC6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLIC6
    Human Genome Epidemiology (HuGE) Navigator: CLIC6 (2 documents)

    Export disorders for CLIC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLIC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
    2. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. (PubMed id 14597386)1, 2, 9 Friedli M.... Reymond A. (2003)
    3. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. (PubMed id 12226712)1, 2 Strippoli P.... Zannotti M. (2002)
    7. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. (PubMed id 14499480)1 Griffon N....Sokoloff P. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1 Scanlan M.J.... Old L.J. (2001)
    10. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54102 HGNC: 2065 AceView: CLIC6 Ensembl:ENSG00000159212 euGenes: HUgn54102
    ECgene: CLIC6 H-InvDB: CLIC6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLIC6 gene:
    Search GeneIP for patents involving CLIC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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