Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLIC6 Gene

Aliases for CLIC6 Gene

  • Chloride Intracellular Channel 6 2 3
  • CLIC1L 3 4 6
  • Parchorin 3 4
  • Chloride Intracellular Channel Protein 6 3
  • Chloride Channel Form A 3

External Ids for CLIC6 Gene

Previous HGNC Symbols for CLIC6 Gene

  • CLIC1L

Previous GeneCards Identifiers for CLIC6 Gene

  • GC21P032657
  • GC21P034962
  • GC21P034963
  • GC21P036041
  • GC21P021520

Summaries for CLIC6 Gene

Entrez Gene Summary for CLIC6 Gene

  • This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC6 Gene

CLIC6 (Chloride Intracellular Channel 6) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC1.

UniProtKB/Swiss-Prot for CLIC6 Gene

  • May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).

Gene Wiki entry for CLIC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC6 Gene

Genomics for CLIC6 Gene

Regulatory Elements for CLIC6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLIC6 Gene

34,669,313 bp from pter
34,718,227 bp from pter
48,915 bases
Plus strand

Genomic View for CLIC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC6 Gene

Proteins for CLIC6 Gene

  • Protein details for CLIC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride intracellular channel protein 6
    Protein Accession:
    Secondary Accessions:
    • A8K0U8
    • Q8IX31

    Protein attributes for CLIC6 Gene

    704 amino acids
    Molecular mass:
    73012 Da
    Quaternary structure:
    • Interacts with dopamine receptors DRD2, DRD3 and DRD4.
    • Sequence=BAC03959.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CLIC6 Gene


neXtProt entry for CLIC6 Gene

Proteomics data for CLIC6 Gene at MOPED

Post-translational modifications for CLIC6 Gene

Other Protein References for CLIC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLIC6 Gene

Domains for CLIC6 Gene

Gene Families for CLIC6 Gene

  • CLIC :Ion channels / Chloride channels : Intracellular

Suggested Antigen Peptide Sequences for CLIC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96NY7
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
  • Contains 1 GST C-terminal domain.
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC6: view

Function for CLIC6 Gene

Molecular function for CLIC6 Gene

UniProtKB/Swiss-Prot Function:
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).

Gene Ontology (GO) - Molecular Function for CLIC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005247 voltage-gated chloride channel activity --
GO:0005254 chloride channel activity IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0031749 D2 dopamine receptor binding IEA --
genes like me logo Genes that share ontologies with CLIC6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLIC6 Gene

Localization for CLIC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC6 Gene

Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CLIC6 Gene COMPARTMENTS Subcellular localization image for CLIC6 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLIC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0034707 chloride channel complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CLIC6: view

Pathways for CLIC6 Gene

genes like me logo Genes that share pathways with CLIC6: view

Pathways by source for CLIC6 Gene

Gene Ontology (GO) - Biological Process for CLIC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0044070 regulation of anion transport --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLIC6: view

Compounds for CLIC6 Gene

(1) HMDB Compounds for CLIC6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
genes like me logo Genes that share compounds with CLIC6: view

Transcripts for CLIC6 Gene

mRNA/cDNA for CLIC6 Gene

Unigene Clusters for CLIC6 Gene

Chloride intracellular channel 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIC6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for CLIC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLIC6 Gene

mRNA expression in normal human tissues for CLIC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIC6 Gene

This gene is overexpressed in Stomach (18.4) and Minor Salivary Gland (4.5).

Protein differential expression in normal tissues for CLIC6 Gene

This gene is overexpressed in Lavage (28.8) and Nasal epithelium (22.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIC6 Gene

SOURCE GeneReport for Unigene cluster for CLIC6 Gene Hs.473695

mRNA Expression by UniProt/SwissProt for CLIC6 Gene

Tissue specificity: Expressed in brain, placenta, pancreas and liver.
genes like me logo Genes that share expressions with CLIC6: view

In Situ Assay Products

No data available for Expression partners for CLIC6 Gene

Orthologs for CLIC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CLIC6 35
  • 77.98 (n)
  • 71.25 (a)
CLIC6 36
  • 64 (a)
(Canis familiaris)
Mammalia CLIC6 35
  • 90.6 (n)
  • 98.24 (a)
CLIC6 36
  • 84 (a)
(Mus musculus)
Mammalia Clic6 35
  • 74.14 (n)
  • 69.69 (a)
Clic6 16
Clic6 36
  • 67 (a)
(Pan troglodytes)
Mammalia CLIC6 35
  • 97.97 (n)
  • 96.34 (a)
CLIC6 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Clic6 35
  • 74.6 (n)
  • 71.26 (a)
(Monodelphis domestica)
Mammalia CLIC6 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CLIC6 36
  • 84 (a)
(Gallus gallus)
Aves CLIC6 36
  • 85 (a)
(Anolis carolinensis)
Reptilia CLIC6 36
  • 49 (a)
(Danio rerio)
Actinopterygii CLIC6 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 23 (a)
exl-1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 46 (a)
Species with no ortholog for CLIC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLIC6 Gene

Gene Tree for CLIC6 (if available)
Gene Tree for CLIC6 (if available)

Paralogs for CLIC6 Gene

Paralogs for CLIC6 Gene

Selected SIMAP similar genes for CLIC6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CLIC6: view

Variants for CLIC6 Gene

Sequence variations from dbSNP and Humsavar for CLIC6 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs717578 -- 34,690,638(+) CGCCA(C/T)ATGAT intron-variant
rs717579 -- 34,690,687(+) GCACA(A/G)CTGCC intron-variant
rs733014 -- 34,691,253(+) AACTG(A/G)AATCT intron-variant
rs762244 -- 34,691,162(+) TGACA(A/T)AGAAC intron-variant
rs1009925 -- 34,677,070(+) GGAGA(C/T)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC6 Gene

Variant ID Type Subtype PubMed ID
nsv3501 CNV Insertion 18451855
esv2670909 CNV Deletion 23128226
esv2723369 CNV Deletion 23290073
nsv828868 CNV Loss 20364138
dgv718n67 CNV Loss 20364138
esv993312 CNV Loss 20482838

Relevant External Links for CLIC6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC6 Gene

Disorders for CLIC6 Gene

Relevant External Links for CLIC6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CLIC6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CLIC6 Gene

Publications for CLIC6 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4
  2. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. (PMID: 14597386) Friedli M. … Reymond A. (Gene 2003) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. (PMID: 12226712) Strippoli P. … Zannotti M. (Mamm. Genome 2002) 3 4

Products for CLIC6 Gene

Sources for CLIC6 Gene

Back to Top