Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC6 Gene

protein-coding   GIFtS: 52
GCID: GC21P036041

chloride intracellular channel 6


(Previous symbol: CLIC1L)
 Explore 3 diseases affiliated with
CLIC6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLIC6    

Aliases
for CLIC6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chloride Intracellular Channel 61 2     Chloride Intracellular Channel Protein 62
CLIC1L1 2 3     Parchorin3
CLIC51     Parchorin3
Chloride Channel Form A2     

External Ids:    HGNC: 20651   Entrez Gene: 541022   Ensembl: ENSG000001592127   UniProtKB: Q96NY73   

Export aliases for CLIC6 gene to outside databases

Previous GC identifers: GC21P032657 GC21P034962 GC21P034963 GC21P021520


Summaries
for CLIC6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLIC6:
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large
triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described,
but its biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells,
possibly through the regulation of chloride ion transport (By similarity)

Gene Wiki entry for CLIC6


Genomic Views
for CLIC6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC6 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   Sp1   Nkx3-1 v1   Egr-4   Nkx3-1 v2   AREB6   HOXA5   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLIC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.12

CLIC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC6 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P036041:  view genomic region     (about GC identifiers)

Start:
 36,041,688 bp from pter      End:
 36,090,525 bp from pter
Size:
 48,838 bases      Orientation:
 plus strand

Proteins
for CLIC6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 6  
Size: 704 amino acids; 73012 Da
Subunit: Interacts with dopamine receptors DRD2, DRD3 and DRD4 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Single-pass membrane protein (By similarity).
Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By
similarity)
Sequence caution: Sequence=BAC03959.1; Type=Erroneous initiation;
Secondary accessions: A8K0U8 Q8IX31
Alternative splicing: 2 isoforms:  Q96NY7-1   Q96NY7-2   

Explore the universe of human proteins at neXtProt for CLIC6: NX_Q96NY7

Post-translational modifications:

  • Phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NY7

    • CLIC6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_444507.1  
    ENSEMBL proteins: 
     ENSP00000353959   ENSP00000290332  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CLIC6 
    GenScript Custom Purified and Recombinant Proteins Services for CLIC6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLIC6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0034707chloride channel complex IEA--


    CLIC6 for ontologies           About GeneDecksing



    CLIC6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CLIC6 
    GenScript Custom Superior Antibodies Services for CLIC6
    Novus Biologicals CLIC6 Antibody
    Search for Antibodies for CLIC6 at Abcam  
    Uscn Antibodies for CLIC6
    ThermoFisher Antibody for CLIC6

    Assay Products for CLIC6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLIC6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CLIC6

    Protein Domains /
    Families
    for CLIC6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLIC6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q96NY7

    ProtoNet protein and cluster: Q96NY7

    1 Blocks protein family: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    Function
    for CLIC6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells,
    possibly through the regulation of chloride ion transport (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CLIC6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmid: CLIC6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC6 (see all 7)
    OriGene shRNA RFP: CLIC6
    OriGene siRNA: CLIC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLIC6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLIC6 (NM_053277)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CLIC6
    Search LifeMap BioReagents cell lines for CLIC6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0031749D2 dopamine receptor binding IEA--
    GO:0031750D3 dopamine receptor binding IEA--
    GO:0031751D4 dopamine receptor binding IEA--


    CLIC6 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CLIC6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC6
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CLIC6 (Q96NY73 ENSP000002903324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD4P219173, ENSP000001761834I2D: score=1 STRING: ENSP00000176183
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    DRD3P354623, ENSP000003731694I2D: score=2 STRING: ENSP00000373169
    About this table

    Drugs & Compounds
    for CLIC6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIC6

    1 HMDB Compound for CLIC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about CLIC6 

    Transcripts
    for CLIC6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLIC6 gene: 
    NM_053277.1  

    Unigene Cluster for CLIC6:

    Chloride intracellular channel 6
    Hs.473695  [show with all ESTs]
    Unigene Representative Sequence: AF448439
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360731(uc010gmt.1) ENST00000349499(uc002yuf.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CLIC6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmid: CLIC6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC6 (see all 7)
    OriGene shRNA RFP: CLIC6
    OriGene siRNA: CLIC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLIC6 (NM_053277)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLIC6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIC6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC6

    Additional cDNA sequence: 

    AF308293.1 AF426169.1 AF448438.1 AF448439.1 AK092733.1 AK289663.1 BC040196.2 

    2 DOTS entries:

    DT.205930  DT.100743038 

    24/67 AceView cDNA sequences (see all 67):

    AI801947 CB243644 BU688348 AW028852 AF448439 AF448438 AF426169 BM720027 
    CA391466 BQ030250 AI252624 AW168083 NM_053277 AI687382 AI433909 AI252646 
    CA425200 AI687177 AA974724 AW182855 AI638295 BG926868 BC040196 AI888988 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -                           
    SP2:        -           -                           
    SP3:                                                


    ECgene alternative splicing isoforms for CLIC6

    Expression
    for CLIC6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAAATGATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLIC6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    TestisSeminiferous TubulesSertoli cellsTestis
    BoneMandibular CondyleBone
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Cardiomyocyte-like cells (Spontaneous differen...)

    See CLIC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC6

    SOURCE GeneReport for Unigene cluster: Hs.473695

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Tissue specificity: Expressed in brain, placenta, pancreas and liver

        SABiosciences Custom PCR Arrays for CLIC6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLIC6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIC6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6

    Orthologs
    for CLIC6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC6 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLIC61 chloride intracellular channel 6 78.8(n)
    91.67(a)    		   427981  XM_425551.3  XP_425551.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CLIC66
    		 --
    		 44(a)
    		 1 ↔ 1
    		 3(142303344-142342279)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1018271 zgc:101827 67.93(n)
    76.05(a)    		   492513  NM_001007385.1  NP_001007386.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Clic6
    		 Chloride intracellular channel
    		 25(a)
    		 1 → many
    		 X(13707165-13716357)
    worm
    (Caenorhabditis elegans)    		 Secernentea exl-16
    exc-46
    		 Chloride intracellular channel exc-4
    		 22(a)
    20(a)
    		 many ↔ many
    many ↔ many
    		 II(14412121-14413389)
    I(14512651-14518707)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DHAR31 glutathione S-transferase DHAR3 49.1(n)
    32.26(a)    		   831532  NM_121676.3  NP_568336.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g02326001 hypothetical protein 45.74(n)
    29.79(a)    		   4340581  NM_001063763.1  NP_001057228.1 


    ENSEMBL Gene Tree for CLIC6 (if available)
    TreeFam Gene Tree for CLIC6 (if available) 

    Paralogs
    for CLIC6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC6 gene
    CLIC32  CLIC12  CLIC52  CLIC22  CLIC42  
    5 SIMAP similar genes for CLIC6 using alignment to 1 protein entry:     CLIC6_HUMAN:
    CLIC4    CLIC5    CLIC1    CLIC2    CLIC3

    CLIC6 for paralogs           About GeneDecksing



    Genomic Variants
    for CLIC6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1066 NCBI SNPs in CLIC6 are shown (see all 1066)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs348769631,2
    		--36039689(+) AAAGGC/TTTGAA 1 -- us2k10--------
    rs72806631,2
    		C,F,H,--36039707(+) ggaggT/Cgaacc 1 -- us2k16Minor allele frequency- C:0.05NS EA CSA WA 540
    rs1422320241,2
    		--36039708(+) GAGGTA/GAACCT 1 -- us2k10--------
    rs1511341981,2
    		--36039721(+) ACTGGA/GGGTGG 1 -- us2k10--------
    rs713243181,2
    		C,F,--36039774(+) GATGCCTAT/-  
                CTGTC     		1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs106486871,2
    		C--36039776(+) TGCCT-/ATCT  
                GTCTT     		1 -- us2k10--------
    rs1133700311,2
    		C--36039777(+) TGCCTA/GTCTTA 1 -- us2k10--------
    rs173996611,2
    		C,--36039837(+) TAATAT/CACAGT 1 -- us2k1 tfbs33Minor allele frequency- C:0.01NA 136
    rs72808451,2
    		C,H--36039870(+) aacaaT/Ctctgt 1 -- us2k15Minor allele frequency- C:0.00NS EA CSA 418
    rs1893085161,2
    		--36039891(+) ACATCC/TGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CLIC6 (36041688 - 36090525 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CLIC6
         4 Indels: 90762 90761 90760 79338

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIC6
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC6

    Disorders / Diseases
    for CLIC6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLIC6 for disorders           About GeneDecksing

    3 diseases for CLIC6:    About MalaCards
    gout    breast cancer    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CLIC6 (2 documents)

    Export disorders for CLIC6 gene to outside databases

    Publications
    for CLIC6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLIC6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
    2. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. (PubMed id 14597386)1, 2, 9 Friedli M.... Reymond A. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. (PubMed id 12226712)1, 2 Strippoli P.... Zannotti M. (2002)
    6. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
    7. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. (PubMed id 14499480)1 Griffon N....Sokoloff P. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1 Scanlan M.J.... Old L.J. (2001)
    10. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)

    External Searches for CLIC6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLIC6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54102 HGNC: 2065 AceView: CLIC6 Ensembl:ENSG00000159212 euGenes: HUgn54102
    ECgene: CLIC6 H-InvDB: CLIC6

    Other Databases showing CLIC6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLIC6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLIC6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLIC6 gene:
    Search GeneIP for patents involving CLIC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CLIC6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CLIC6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLIC6  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CLIC6   OriGene 3'-UTR Clone for CLIC6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CLIC6   OriGene Custom Protein Services for CLIC6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLIC6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIC6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC6
     GenScript Custom Purified and Recombinant Proteins Services for CLIC6 GenScript cDNA clones with any tag delivered in your preferred vector for CLIC6
     GenScript Custom Assay Services for CLIC6 GenScript Custom Superior Antibodies Services for CLIC6
     GenScript Custom overexpressing Cell Line Services for CLIC6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLIC6 promoter
     Search Chromatin IP Primers for CLIC6
     RT2 qPCR Primer Assay in human, mouse, rat CLIC6
     GNC Network for CLIC6
     SABiosciences PCR Arrays including human, mouse, rat CLIC6
     Search Tocris compounds for CLIC6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CLIC6 antibodies
     Search for Antibodies for CLIC6 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CLIC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CLIC6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CLIC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6
     SwitchGear 3'UTR luciferase reporter plasmids for CLIC6
     SwitchGear Promoter luciferase reporter plasmids for CLIC6
     ThermoFisher Antibody for CLIC6
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CLIC6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4