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CLIC6 Gene

protein-coding   GIFtS: 54
GCID: GC21P036041

Chloride Intracellular Channel 6


(Previous symbol: CLIC1L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chloride Intracellular Channel 61 2
CLIC1L1 2 3 5
Chloride Channel Form A2
Chloride Intracellular Channel Protein 62
parchorin2
Parchorin3

External Ids:    HGNC: 20651   Entrez Gene: 541022   Ensembl: ENSG000001592127   OMIM: 6153215   UniProtKB: Q96NY73   

Export aliases for CLIC6 gene to outside databases

Previous GC identifers: GC21P032657 GC21P034962 GC21P034963 GC21P021520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLIC6 Gene:
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large
triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been
described, but its biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC6 Gene:
CLIC6 (chloride intracellular channel 6) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC3.

UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting
cells, possibly through the regulation of chloride ion transport (By similarity)

Gene Wiki entry for CLIC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLIC6 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   Sp1   Nkx3-1 v1   Egr-4   Nkx3-1 v2   AREB6   HOXA5   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC6 promoter sequence
   Search Chromatin IP Primers for CLIC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLIC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.12   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.12

CLIC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC6 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P036041:  view genomic region     (about GC identifiers)

Start:
36,041,688 bp from pter      End:
36,090,525 bp from pter
Size:
48,838 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 6  
Size: 704 amino acids; 73012 Da
Subunit: Interacts with dopamine receptors DRD2, DRD3 and DRD4 (By similarity)
Sequence caution: Sequence=BAC03959.1; Type=Erroneous initiation;
Secondary accessions: A8K0U8 Q8IX31
Alternative splicing: 2 isoforms:  Q96NY7-1   Q96NY7-2   

Explore the universe of human proteins at neXtProt for CLIC6: NX_Q96NY7

Explore proteomics data for CLIC6 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLIC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_444507.1  
    ENSEMBL proteins: 
     ENSP00000353959   ENSP00000290332  

    CLIC6 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CLIC6

     
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    Search antibodies-online for proteins for CLIC6 

     
    antibodies-online peptides for CLIC6

    CLIC6 Antibody Products:

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    antibodies-online antibodies for CLIC6 (47 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q96NY7

    ProtoNet protein and cluster: Q96NY7

    1 Blocks protein domain: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    Find genes that share domains with CLIC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC6_HUMAN, Q96NY7
    Function: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting
    cells, possibly through the regulation of chloride ion transport (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0031749D2 dopamine receptor binding IEA--
    GO:0031750D3 dopamine receptor binding IEA--
    GO:0031751D4 dopamine receptor binding IEA--
         
    Find genes that share ontologies with CLIC6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CLIC6

    miRNA
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    Block miRNA regulation of human, mouse, rat CLIC6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidCLIC6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLIC6

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    GenScript: all cDNA clones in your preferred vector: CLIC6 (NM_053277)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLIC6_HUMAN, Q96NY7: Cytoplasm (By similarity). Cell membrane; Single-pass membrane protein (By similarity).
    Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CLIC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLIC6 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLIC6
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLIC6
    Interactions:

        GeneGlobe Interaction Network for CLIC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CLIC6 (Q96NY73 ENSP000002903324) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD4P219173, ENSP000001761834I2D: score=1 STRING: ENSP00000176183
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    DRD3P354623, ENSP000003731694I2D: score=2 STRING: ENSP00000373169
    UMPSENSP000002326074STRING: ENSP00000232607
    HIBCHENSP000003527064STRING: ENSP00000352706
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport ----

    Find genes that share ontologies with CLIC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLIC6

    1 HMDB Compound for CLIC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLIC6 gene: 
    NM_053277.1  

    Unigene Cluster for CLIC6:

    Chloride intracellular channel 6
    Hs.473695  [show with all ESTs]
    Unigene Representative Sequence: AF448439
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360731(uc010gmt.1) ENST00000349499(uc002yuf.1)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CLIC6:
    hsa-miR-1290 hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-802 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidCLIC6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CLIC6
    Predesigned siRNA for gene silencing in human, mouse, rat CLIC6
    Clone
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    OriGene ORF clones in mouse, rat for CLIC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLIC6 (NM_053277)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CLIC6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CLIC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLIC6
      QuantiTect SYBR Green Assays in human, mouse, rat CLIC6
      QuantiFast Probe-based Assays in human, mouse, rat CLIC6

    Additional mRNA sequence: 

    AF308293.1 AF426169.1 AF448438.1 AF448439.1 AK092733.1 AK289663.1 BC040196.2 

    2 DOTS entries:

    DT.205930  DT.100743038 

    Selected AceView cDNA sequences (see all 67):

    AI801947 AI252624 BQ030250 BM720027 AW182855 NM_053277 AW168083 CA425200 
    BU688348 CB243644 AI687382 AI433909 AI252646 AA974724 AI687177 AF426169 
    AF448438 AF448439 AW028852 CA391466 BV184382 AI888988 BG926868 AI638295 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -                           
    SP2:        -           -                           
    SP3:                                                


    ECgene alternative splicing isoforms for CLIC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLIC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAATGATT
    CLIC6 Expression
    About this image


    CLIC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Mandibular Condyle
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    CLIC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLIC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473695

    UniProtKB/Swiss-Prot: CLIC6_HUMAN, Q96NY7
    Tissue specificity: Expressed in brain, placenta, pancreas and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLIC6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic61 , 5 chloride intracellular channel 61, 5 74.14(n)1
    69.69(a)1
      16 (53.64 cM)5
    2091951  NM_172469.31  NP_766057.11 
     924857365 
    chicken
    (Gallus gallus)
    Aves CLIC66
    chloride intracellular channel 6
    85(a)
    1 ↔ 1
    1(105365175-105370830)
    lizard
    (Anolis carolinensis)
    Reptilia CLIC66
    chloride intracellular channel 6
    49(a)
    1 ↔ 1
    3(142300053-142342279)
    zebrafish
    (Danio rerio)
    Actinopterygii CLIC66
    chloride intracellular channel 6
    74(a)
    1 ↔ 1
    1(1318859-1331666) ENSDARG00000001009
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    27(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Protein EXC-4 (exc-4) mRNA, complete cds
    26(a)
    23(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465) WBGene00001371
    I(14512663-14518719) WBGene00001365


    ENSEMBL Gene Tree for CLIC6 (if available)
    TreeFam Gene Tree for CLIC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLIC6 gene
    CLIC32  CLIC12  CLIC52  CLIC22  CLIC42  
    5 SIMAP similar genes for CLIC6 using alignment to 1 protein entry:     CLIC6_HUMAN:
    CLIC4    CLIC5    CLIC1    CLIC2    CLIC3

    Find genes that share paralogs with CLIC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLIC6 (see all 1244)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348769631,2
    C,F--36039689(+) AAAGGC/TTTGAA 1 -- us2k10--------
    rs72806631,2
    C,F,H--36039707(+) ggaggT/Cgaacc 1 -- us2k16Minor allele frequency- C:0.05NS EA CSA WA 540
    rs1422320241,2
    --36039708(+) GAGGTA/GAACCT 1 -- us2k10--------
    rs1511341981,2
    --36039721(+) ACTGGA/GGGTGG 1 -- us2k10--------
    rs713243181,2
    C,F--36039774(+) GATGCCTAT/-  
            
    CCTGT
    1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1464518881,2
    C--36039775(+) ATGCC-/CTAT  
            
    TGTCT
    1 -- us2k10--------
    rs106486871,2
    C--36039776(+) TGCCT-/ATCT  
            
    GTCTT
    1 -- us2k10--------
    rs1133700311,2
    C--36039777(+) TGCCTA/GTCTTA 1 -- us2k10--------
    rs173996611,2
    C,F--36039837(+) TAATAT/CACAGT 1 -- us2k1 tfbs33Minor allele frequency- C:0.01NA 136
    rs72808451,2
    C,H--36039870(+) aacaaT/Ctctgt 1 -- us2k15Minor allele frequency- C:0.00NS EA CSA 418

    HapMap Linkage Disequilibrium report for CLIC6 (36041688 - 36090525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CLIC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670909CNV Deletion23128226
    esv2723369CNV Deletion23290073
    nsv3501CNV Insertion18451855
    esv993312CNV Loss20482838
    nsv828868CNV Loss20364138
    dgv718n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): CLIC6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLIC6
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615321    OMIM disorders: --


    Find genes that share disorders with CLIC6           About GenesLikeMe

    Genetic Association Database (GAD): CLIC6
    Human Genome Epidemiology (HuGE) Navigator: CLIC6 (2 documents)

    Export disorders for CLIC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLIC6 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CLIC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M.... Yaspo M.-L. (Nature 2000)
    2. Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. (PubMed id 14597386)1, 2, 9 Friedli M.... Reymond A. (Gene 2003)
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. (PubMed id 12226712)1, 2 Strippoli P.... Zannotti M. (Mamm. Genome 2002)
    7. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    8. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. (PubMed id 14499480)1 Griffon N....Sokoloff P. (Brain Res. Mol. Brain Res. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1 Scanlan M.J.... Old L.J. (Cancer Immun. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54102 HGNC: 2065 AceView: CLIC6 Ensembl:ENSG00000159212 euGenes: HUgn54102
    ECgene: CLIC6 H-InvDB: CLIC6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLIC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLIC6 gene:
    Search GeneIP for patents involving CLIC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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