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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC5 Gene

protein-coding   GIFtS: 56
GCID: GC06M045848

chloride intracellular channel 5
 Explore 4 diseases affiliated with
CLIC5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLIC5    

Aliases
for CLIC5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chloride Intracellular Channel 51 2
MST1302
MSTP1302
Chloride Intracellular Channel Protein 52

External Ids:    HGNC: 135171   Entrez Gene: 534052   Ensembl: ENSG000001127827   OMIM: 6072935   UniProtKB: Q9NZA13   

Export aliases for CLIC5 gene to outside databases

Previous GC identifers: GC06M045871 GC06M045916 GC06M045977 GC06M045589


Summaries
for CLIC5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLIC5:
This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded
protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair
cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: CLIC5_HUMAN, Q9NZA1
Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May
play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of
stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Is required for the
development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture

Gene Wiki entry for CLIC5


Genomic Views
for CLIC5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC5 gene promoter:
         C/EBPbeta   AML1a   SREBP-1c   SREBP-1b   SREBP-1a   POU2F1   POU2F1b   FOXO1a   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLIC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.3

CLIC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M045848:  view genomic region     (about GC identifiers)

Start:
 45,848,750 bp from pter      End:
 46,048,132 bp from pter
Size:
 199,383 bases      Orientation:
 minus strand

Proteins
for CLIC5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLIC5_HUMAN, Q9NZA1 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 5  
Size: 410 amino acids; 46503 Da
Subunit: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin,
alpha-actinin, gelsolin, and IQGAP1. Interacts with AKAP9
Subcellular location: Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Single-pass membrane
protein. Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as
membrane protein with probably a single transmembrane domain (By similarity)
Subcellular location: Isoform 2: Golgi apparatus. Cytoplasm, cytoskeleton, centrosome. Membrane; Single-pass membrane
protein. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists
both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By
similarity). Colocalized with podocalyxin in renal glomeruli
Secondary accessions: B3KUF1 Q5T4Z0 Q8NBY3 Q96JT5 Q9BWZ0
Alternative splicing: 3 isoforms:  Q9NZA1-1   Q9NZA1-2   Q9NZA1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CLIC5: NX_Q9NZA1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZA1

    • CLIC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001107558.1  NP_001242952.1  NP_058625.2  

    ENSEMBL proteins: 
     ENSP00000185206   ENSP00000344165   ENSP00000439195  

    Human Recombinant Protein Products: 
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    Novus Biologicals CLIC5 Protein
    Novus Biologicals CLIC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLIC5

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005938cell cortex IEA--
    GO:0015629actin cytoskeleton IDA10793131
    GO:0016020membrane ----


    CLIC5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CLIC5

    Protein Domains /
    Families
    for CLIC5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLIC5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9NZA1

    ProtoNet protein and cluster: Q9NZA1

    1 Blocks protein family: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC5_HUMAN, Q9NZA1
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    Function
    for CLIC5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLIC5_HUMAN, Q9NZA1
    Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May
    play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of
    stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Is required for the
    development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture

    miRNA
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    hsa-miR-579 hsa-miR-4254 hsa-miR-188-5p hsa-miR-200a hsa-miR-138-2* hsa-miR-650 hsa-miR-570 hsa-miR-10b*
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity ----
    GO:0005515protein binding IPI12163479


    CLIC5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CLIC5:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Clic5):
     behavior/neurological  hearing/vestibular/ear  nervous system  respiratory system 

    CLIC5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CLIC5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC5
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for CLIC5 (Q9NZA12, 3 ENSP000001852064) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    GSNP063963, ENSP000003629244I2D: score=1 STRING: ENSP00000362924
    IQGAP1P469403, ENSP000002681824I2D: score=1 STRING: ENSP00000268182
    ACTN1ENSP000003779414STRING: ENSP00000377941
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002024diet induced thermogenesis IEA--
    GO:0006810transport NAS10793131
    GO:0006821chloride transport IDA10793131
    GO:0007565female pregnancy TAS10793131
    GO:0007605sensory perception of sound IEA--


    CLIC5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLIC5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIC5

    1 HMDB Compound for CLIC5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about CLIC5 

    Transcripts
    for CLIC5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLIC5 gene (3 alternative transcripts): 
    NM_001114086.1  NM_001256023.1  NM_016929.4  

    Unigene Cluster for CLIC5:

    Chloride intracellular channel 5
    Hs.485489  [show with all ESTs]
    Unigene Representative Sequence: NM_001114086
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487396 ENST00000185206(uc003oxv.3) ENST00000339561(uc003oxu.3)
    ENST00000484572 ENST00000486570 ENST00000476852 ENST00000464137 ENST00000544153(uc003oxw.3 uc003oxx.3)


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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC5 (see all 37):
    hsa-miR-579 hsa-miR-4254 hsa-miR-188-5p hsa-miR-200a hsa-miR-138-2* hsa-miR-650 hsa-miR-570 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC5 (see all 7)
    OriGene shRNA RFP: CLIC5
    OriGene siRNA: CLIC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC5
    Clone
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    Additional cDNA sequence: 

    AF086005.1 AF176920.1 AF216941.1 AJ420547.1 AK025350.1 AK075144.1 AK075163.1 AK097048.1 
    AK222544.1 AK223130.1 AK314416.1 AL049313.1 AY032602.1 BC020923.1 BC035968.1 BC039380.1 
    DQ679794.1 NR_045672.1 NR_045673.1 NR_045674.1 

    8 DOTS entries:

    DT.412115  DT.97825233  DT.95074374  DT.91867981  DT.40111179  DT.121317408  DT.100748292  DT.91705033 

    24/140 AceView cDNA sequences (see all 140):

    CA389189 BQ185826 Z40714 BU753008 AW772280 BU753319 BG413416 BF036159 
    AI431900 BM914594 BC035968 AI298427 CA407711 BM998735 BU740699 BP369816 
    AW611567 BE677093 NM_016929 AA918152 AA569128 H65200 BQ025920 AI243245 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC5 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
    SP1:        -     -           -                       -     -     -     -     -                 -     -                     
    SP2:                          -                       -     -     -     -     -                 -     -                     
    SP3:                          -                       -     -     -     -     -                 -                           
    SP4:                                                                                            -                           
    SP5:                                                  -     -     -     -                                                   


    ECgene alternative splicing isoforms for CLIC5

    Expression
    for CLIC5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATCTGAACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLIC5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPresumptive PodocytesKidney
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    KidneyPodocyte LayerPodocytesKidney
    AdiposeInterscapular Brown Adipose DepotAdipose
    Gut TubeMidgutGut Tube
    KidneyGlomerulusKidney
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See CLIC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC5

    SOURCE GeneReport for Unigene cluster: Hs.485489

    UniProtKB/Swiss-Prot: CLIC5_HUMAN, Q9NZA1
    Tissue specificity: Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including CLIC5: 
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              Hypertension in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CLIC5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC5 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CLIC51 chloride intracellular channel 5 66.67(n)
    64.69(a)    		   422054  XM_420060.2  XP_420060.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CLIC56
    		 --
    		 89(a)
    		 1 ↔ 1
    		 1(138689856-138715612)
    African clawed frog
    (Xenopus laevis)    		 Amphibia clic5-prov2 chloride intracellular channel 5 77.94(n)    BC056036.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003296421 chloride intracellular channel protein 5-like 61.92(n)
    60.62(a)    		   100329642  XM_002665755.1  XP_002665801.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Clic1 Chloride intracellular channel 51.24(n)
    38.31(a)    		   32349  NM_132700.2  NP_572928.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea exl-16
    exc-46
    		 Chloride intracellular channel exc-4
    		 24(a)
    19(a)
    		 many ↔ many
    many ↔ many
    		 II(14412121-14413389)
    I(14512651-14518707)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DHAR26
    DHAR36
    (see all 4)    		 glutathione S-transferase DHAR3
    (see all 4)    		 25(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(28250075-28251350)
    5(5483288-5485081)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 glutathione S-transferase, N-terminal domain conta...
    glutathione S-transferase, N-terminal domain conta...
    		 21(a)
    20(a)
    		 many ↔ many
    many ↔ many
    		 6(6889586-6894645)
    5(876932-880610)


    ENSEMBL Gene Tree for CLIC5 (if available)
    TreeFam Gene Tree for CLIC5 (if available) 

    Paralogs
    for CLIC5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC5 gene
    CLIC62  CLIC32  CLIC12  CLIC22  CLIC42  
    6 SIMAP similar genes for CLIC5 using alignment to 4 protein entries:     CLIC5_HUMAN (see all proteins):
    MST130    CLIC6    CLIC4    CLIC1    CLIC3    CLIC2

    CLIC5 for paralogs           About GeneDecksing



    Genomic Variants
    for CLIC5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3592 NCBI SNPs in CLIC5 are shown (see all 3592)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs728701021,2
    		C,F,--45589092(+) TCTTCT/CTCCTC 4 -- ds50011Minor allele frequency- C:0.02NA 120
    rs40725911,2
    		F,--45589339(-) tatttT/Cagtag 4 -- ds50011Minor allele frequency- C:0.07NA 120
    rs94726081,2
    		C,F,H,--45589744(+) AAACAC/GTTGTT 4 -- ut31 nc-transcript-variant7Minor allele frequency- G:0.03NS EA NA CSA WA 718
    rs600942661,2
    		C,F,--45590064(+) TTAACG/ATTAAA 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.14WA 118
    rs610026831,2
    		C,F,--45590097(+) CATACA/GTAATT 4 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.09WA 118
    rs1120794411,2
    		C,--45590204(+) ATGATG/AAAGAG 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.50CSA 2
    rs728714041,2
    		C,F,--45590297(+) ATGCAC/TATGTC 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02NA 120
    rs794093281,2
    		C,F,--45590476(+) AGTGGG/AAATTG 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs1875316351,2
    		C,--45590529(+) TCTAGC/TTTAAT 4 -- ut31 nc-transcript-variant0--------
    rs2004445781,2
    		C--45591584(+) CTTTTA/GAAACA 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CLIC5 (45848750 - 46048132 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for CLIC5
         3 CNVs: 99526 0078 2628
         4 Indels: 12838 47125 28312 42334

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIC5
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC5

    Disorders / Diseases
    for CLIC5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLIC5 for disorders           About GeneDecksing

    OMIM gene information: 607293    OMIM disorders: --

    4 diseases for CLIC5:    About MalaCards
    juvenile myoclonic epilepsy    migraine    breast cancer    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CLIC5 (2 documents)

    Export disorders for CLIC5 gene to outside databases

    Publications
    for CLIC5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CLIC5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 3, 9 Berryman M. and Bretscher A. (2000)
    2. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. (PubMed id 12163479)1, 2, 9 Shanks R.A.... Goldenring J.R. (2002)
    3. CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity. (PubMed id 20335315)1, 2, 9 Wegner B....Ballermann B.J. (2010)
    4. Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin. (PubMed id 18028448)1, 2 Singh H.... Ashley R.H. (2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo. (PubMed id 15184393)1, 2 Berryman M.... Edwards J.C. (2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    10. The CLIC5 (chloride intracellular channel 5) involved in C2C12 myoblasts proliferation and differentiation. (PubMed id 20055760)1, 9 Li F....Zhang H. (2010)

    External Searches for CLIC5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLIC5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53405 HGNC: 13517 AceView: CLIC5 Ensembl:ENSG00000112782 euGenes: HUgn53405
    ECgene: CLIC5 H-InvDB: CLIC5

    Other Databases showing CLIC5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLIC5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLIC5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLIC5 gene:
    Search GeneIP for patents involving CLIC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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