Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLIC4 Gene

Aliases for CLIC4 Gene

  • Chloride Intracellular Channel 4 2 3
  • Intracellular Chloride Ion Channel Protein P64H1 3 4
  • Chloride Intracellular Channel Protein 4 3
  • Chloride Intracellular Channel 4 Like 3
  • CLIC4L 3
  • MTCLIC 3
  • P64H1 3
  • HuH1 3
  • H1 3

External Ids for CLIC4 Gene

Summaries for CLIC4 Gene

Entrez Gene Summary for CLIC4 Gene

  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC4 Gene

CLIC4 (Chloride Intracellular Channel 4) is a Protein Coding gene. Diseases associated with CLIC4 include pancreatic cancer. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC1.

UniProtKB/Swiss-Prot for CLIC4 Gene

  • Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Gene Wiki entry for CLIC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC4 Gene

Genomics for CLIC4 Gene

Genomic Location for CLIC4 Gene

Start:
24,745,269 bp from pter
End:
24,844,324 bp from pter
Size:
99,056 bases
Orientation:
Plus strand

Genomic View for CLIC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC4 Gene

Regulatory Elements for CLIC4 Gene

Proteins for CLIC4 Gene

  • Protein details for CLIC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y696-CLIC4_HUMAN
    Recommended name:
    Chloride intracellular channel protein 4
    Protein Accession:
    Q9Y696
    Secondary Accessions:
    • Q9UFW9
    • Q9UQJ6

    Protein attributes for CLIC4 Gene

    Size:
    253 amino acids
    Molecular mass:
    28772 Da
    Quaternary structure:
    • Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9.

    Three dimensional structures from OCA and Proteopedia for CLIC4 Gene

neXtProt entry for CLIC4 Gene

Proteomics data for CLIC4 Gene at MOPED

Post-translational modifications for CLIC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys62, Lys130, Lys146, Lys199, and Lys212

Other Protein References for CLIC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLIC4 Gene

Domains for CLIC4 Gene

Gene Families for CLIC4 Gene

HGNC:
  • CLIC :Ion channels / Chloride channels : Intracellular

UniProtKB/Swiss-Prot:

CLIC4_HUMAN
Domain:
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.:
    • Q9Y696
  • Contains 1 GST C-terminal domain.:
    • Q9Y696
Family:
  • Belongs to the chloride channel CLIC family.:
    • Q9Y696
genes like me logo Genes that share domains with CLIC4: view

Function for CLIC4 Gene

Molecular function for CLIC4 Gene

UniProtKB/Swiss-Prot Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
UniProtKB/Swiss-Prot Induction: Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.

Gene Ontology (GO) - Molecular Function for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005247 voltage-gated chloride channel activity --
GO:0005254 chloride channel activity IEA --
GO:0005515 protein binding IPI 10793131
genes like me logo Genes that share ontologies with CLIC4: view
genes like me logo Genes that share phenotypes with CLIC4: view

Animal Models for CLIC4 Gene

MGI Knock Outs for CLIC4:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLIC4 Gene

Localization for CLIC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIC4 Gene COMPARTMENTS Subcellular localization image for CLIC4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 5
vacuole 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 14569596
GO:0005813 centrosome IDA 14569596
GO:0005829 cytosol IDA 10026142
genes like me logo Genes that share ontologies with CLIC4: view

Pathways for CLIC4 Gene

genes like me logo Genes that share pathways with CLIC4: view

Pathways by source for CLIC4 Gene

1 Cell Signaling Technology pathway for CLIC4 Gene

Gene Ontology (GO) - Biological Process for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001886 endothelial cell morphogenesis IEA --
GO:0006821 chloride transport NAS 10793131
GO:0006915 apoptotic process IEA --
GO:0007035 vacuolar acidification IEA --
genes like me logo Genes that share ontologies with CLIC4: view

Compounds for CLIC4 Gene

(1) HMDB Compounds for CLIC4 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6

(1) Novoseek inferred chemical compound relationships for CLIC4 Gene

Compound -log(P) Hits PubMed IDs
chloride 75.4 17
genes like me logo Genes that share compounds with CLIC4: view

Transcripts for CLIC4 Gene

Unigene Clusters for CLIC4 Gene

Chloride intracellular channel 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for CLIC4 Gene

GeneLoc Exon Structure for
CLIC4
ECgene alternative splicing isoforms for
CLIC4

Expression for CLIC4 Gene

mRNA expression in normal human tissues for CLIC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIC4 Gene

This gene is overexpressed in Artery - Tibial (5.1) and Artery - Aorta (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIC4 Gene

SOURCE GeneReport for Unigene cluster for CLIC4 Gene Hs.440544

mRNA Expression by UniProt/SwissProt for CLIC4 Gene

Q9Y696-CLIC4_HUMAN
Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
genes like me logo Genes that share expressions with CLIC4: view

Orthologs for CLIC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLIC4 36
  • 99.87 (n)
  • 100 (a)
CLIC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLIC4 36
  • 94.73 (n)
  • 98.81 (a)
CLIC4 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIC4 36
  • 95.52 (n)
  • 98.42 (a)
CLIC4 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clic4 36
  • 88.41 (n)
  • 98.81 (a)
Clic4 16
Clic4 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLIC4 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIC4 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clic4 36
  • 88.93 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves CLIC4 36
  • 78.4 (n)
  • 88 (a)
CLIC4 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIC4 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3485 36
tropical clawed frog
(Silurana tropicalis)
Amphibia clic5 36
  • 76.46 (n)
  • 86.51 (a)
Str.20225 36
zebrafish
(Danio rerio)
Actinopterygii clic4 36
  • 75 (n)
  • 86.11 (a)
clic4 37
  • 85 (a)
OneToOne
wufc47b04 36
fruit fly
(Drosophila melanogaster)
Insecta Clic 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-4 37
  • 21 (a)
ManyToMany
exl-1 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2986 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 37
  • 46 (a)
OneToMany
Species with no ortholog for CLIC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLIC4 Gene

ENSEMBL:
Gene Tree for CLIC4 (if available)
TreeFam:
Gene Tree for CLIC4 (if available)

Paralogs for CLIC4 Gene

Paralogs for CLIC4 Gene

Selected SIMAP similar genes for CLIC4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CLIC4 Gene

genes like me logo Genes that share paralogs with CLIC4: view

Variants for CLIC4 Gene

Sequence variations from dbSNP and Humsavar for CLIC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9259 -- 24,841,633(-) AAAAC(C/G)CTCAC utr-variant-3-prime
rs12439 -- 24,843,143(+) TGTCT(A/G)TTGTG utr-variant-3-prime
rs1139995 -- 24,844,269(-) TATCA(A/T)AAAGG utr-variant-3-prime
rs1890449 -- 24,749,310(-) ATACC(G/T)CTTGG intron-variant
rs1981195 -- 24,766,982(+) aatta(C/T)cttgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC4 Gene

Variant ID Type Subtype PubMed ID
nsv870740 CNV Gain 21882294
nsv522437 CNV Gain 19592680
nsv871066 CNV Loss 21882294
nsv871535 CNV Loss 21882294
nsv7076 CNV Loss 18451855
esv2525447 CNV Deletion 19546169
esv2082154 CNV Deletion 18987734
nsv511684 CNV Loss 21212237
esv3809 CNV Deletion 18987735
esv2745530 CNV Deletion 23290073
nsv498666 CNV Loss 21111241
esv995974 CNV Deletion 20482838
esv1446144 CNV Deletion 17803354
esv995045 CNV Deletion 20482838
nsv160319 CNV Loss 16902084
esv7429 CNV Loss 19470904

Relevant External Links for CLIC4 Gene

HapMap Linkage Disequilibrium report
CLIC4

Disorders for CLIC4 Gene

(1) MalaCards Diseases for CLIC4 Gene

Search for CLIC4 Gene in MalaCards »

(6) Novoseek inferred disease relationships for CLIC4 Gene

Disease -log(P) Hits PubMed IDs
stromal tumors 59.3 2
epithelial tumor 46.4 2
necrosis 4.16 1
cancer 3.24 13
breast cancer 0 2

Relevant External Links for CLIC4

Genetic Association Database (GAD)
CLIC4
Human Genome Epidemiology (HuGE) Navigator
CLIC4
genes like me logo Genes that share disorders with CLIC4: view

No data available for UniProtKB/Swiss-Prot for CLIC4 Gene

Publications for CLIC4 Gene

  1. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PMID: 10793131) Berryman M. … Bretscher A. (Mol. Biol. Cell 2000) 3 4 23
  2. Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. (PMID: 12163372) Ronnov-Jessen L. … Petersen O.W. (Am. J. Pathol. 2002) 3 4 23
  3. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PMID: 17200346) Suh K.S. … Yuspa S.H. (Clin. Cancer Res. 2007) 3 4 23
  4. Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. (PMID: 16239224) Bohman S. … Claesson-Welsh L. (J. Biol. Chem. 2005) 3 4 23
  5. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. (PMID: 19247789) Tung J.J. … Kitajewski J. (Angiogenesis 2009) 3 4 23

Products for CLIC4 Gene

Sources for CLIC4 Gene

Back to Top

Content