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CLIC4 Gene

protein-coding   GIFtS: 61
GCID: GC01P025071

Chloride Intracellular Channel 4

  See CLIC4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chloride Intracellular Channel 41 2     Chloride Intracellular Channel 4 Like2
Intracellular Chloride Ion Channel Protein P64H12 3     Chloride Intracellular Channel Protein 42
CLIC4L2     huH12
H12     p64H12
MTCLIC2     

External Ids:    HGNC: 135181   Entrez Gene: 259322   Ensembl: ENSG000001695047   OMIM: 6065365   UniProtKB: Q9Y6963   

Export aliases for CLIC4 gene to outside databases

Previous GC identifers: GC01P024596 GC01P024141 GC01P024423 GC01P024817 GC01P024944 GC01P023328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLIC4 Gene:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including
stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and
regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a
member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in
Panc-1 cells (pancreatic cancer cells). (provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC4 Gene:
CLIC4 (chloride intracellular channel 4) is a protein-coding gene. Diseases associated with CLIC4 include pancreatic cancer. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.
Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under
oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential
role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could
also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)

Gene Wiki entry for CLIC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLIC4 gene promoter:
         C/EBPbeta   Pax-5   FOXO3b   Evi-1   S8   Zic1   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC4 promoter sequence
   Search Chromatin IP Primers for CLIC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLIC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

CLIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P025071:  view genomic region     (about GC identifiers)

Start:
25,071,760 bp from pter      End:
25,170,815 bp from pter
Size:
99,056 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 4  
Size: 253 amino acids; 28772 Da
Subunit: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin,
alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin,
tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9
3 PDB 3D structures from and Proteopedia for CLIC4:
2AHE (3D)        2D2Z (3D)        3OQS (3D)    
Secondary accessions: Q9UFW9 Q9UQJ6

Explore the universe of human proteins at neXtProt for CLIC4: NX_Q9Y696

Explore proteomics data for CLIC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys62, Lys130, Lys146, Lys199, Lys212
  • Modification sites at PhosphoSitePlus

  • See CLIC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_039234.1  
    ENSEMBL proteins: 
     ENSP00000363500   ENSP00000436538  

    CLIC4 Human Recombinant Protein Products:

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    Novus Biologicals CLIC4 Lysate
    Sino Biological Recombinant Protein for CLIC4
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    antibodies-online proteins for CLIC4 (20 products) 

     
    antibodies-online peptides for CLIC4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9Y696

    ProtoNet protein and cluster: Q9Y696

    1 Blocks protein domain: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    Find genes that share domains with CLIC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC4_HUMAN, Q9Y696
    Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.
    Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under
    oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential
    role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could
    also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)
    Induction: Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity TAS9295337
    GO:0005515protein binding IPI10793131
         
    Find genes that share ontologies with CLIC4           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CLIC4:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M  Large nuclei 
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Clic4):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  reproductive system  vision/eye 

    Find genes that share phenotypes with CLIC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CLIC4: Clic4tm1.1Yus Clic4tm1Jce Clic4tm1.1Aidi

       genOway: Develop your customized and physiologically relevant rodent model for CLIC4

    miRNA
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    miRTarBase miRNAs that target CLIC4:
    hsa-mir-26a-5p (MIRT050194), hsa-mir-10a-3p (MIRT038674), hsa-mir-335-5p (MIRT018964), hsa-mir-130b-3p (MIRT044169), hsa-mir-193b-3p (MIRT016555), hsa-mir-142-3p (MIRT021633), hsa-mir-155-5p (MIRT020967), hsa-mir-122-5p (MIRT023398)

    Block miRNA regulation of human, mouse, rat CLIC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CLIC4 (see all 44):
    hsa-miR-3194-5p hsa-miR-429 hsa-miR-128 hsa-miR-1258 hsa-miR-29b-1* hsa-miR-502-3p hsa-miR-374c hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLIC4_HUMAN, Q9Y696: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle
    membrane; Single-pass membrane protein (Probable). Nucleus matrix. Cell membrane; Single-pass membrane protein
    (Probable). Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both
    as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an
    intracellular vesicular compartment that likely represent trans-Golgi network vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    mitochondrion5
    nucleus5
    plasma membrane5
    vacuole2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA14569596
    GO:0005813centrosome IDA14569596
    GO:0005829cytosol IDA10026142

    Find genes that share ontologies with CLIC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLIC4 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    4Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with CLIC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLIC4
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 Cell Signaling Technology (CST) Pathway for CLIC4
        Glucose / Energy Metabolism



        Pathway & Disease-focused RT2 Profiler PCR Array including CLIC4: 
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLIC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CLIC4 (Q9Y6962, 3 ENSP000003635004) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=3 STRING: ENSP00000349960
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    DNM1Q051933, ENSP000003620144I2D: score=3 STRING: ENSP00000362014
    YWHAZP631043, ENSP000003095034I2D: score=3 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0006821chloride transport NAS10793131
    GO:0007035vacuolar acidification IEA--
    GO:0009566fertilization IEA--

    Find genes that share ontologies with CLIC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLIC4

    1 HMDB Compound for CLIC4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 Novoseek inferred chemical compound relationship for CLIC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 75.4 28 12163372 (2), 16239224 (2), 12237120 (1), 17353112 (1) (see all 15)



    Find genes that share compounds with CLIC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLIC4 gene: 
    NM_013943.2  

    Unigene Cluster for CLIC4:

    Chloride intracellular channel 4
    Hs.440544  [show with all ESTs]
    Unigene Representative Sequence: NM_013943
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374379(uc001bjo.2) ENST00000497755 ENST00000488683(uc001bjp.1)
    ENST00000489758
    miRNA
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    Additional mRNA sequence: 

    AF097330.1 AF109196.1 AK001624.1 AK095959.1 AK301466.1 AK307142.1 AK308909.1 AK315051.1 
    AL080061.1 AL117424.1 AL162008.1 BC012444.1 CR533501.1 Z24740.1 Z24749.1 

    21 DOTS entries:

    DT.450018  DT.100879680  DT.100799672  DT.100879681  DT.121399506  DT.97769294  DT.92452587  DT.121399521 
    DT.121399596  DT.121399511  DT.40123733  DT.92452589  DT.95249991  DT.121399526  DT.100879687  DT.101979659 
    DT.121399524  DT.121399547  DT.121399560  DT.121399621  DT.121399632 

    Selected AceView cDNA sequences (see all 683):

    AI719844 BQ433262 BQ437297 BQ002288 AA913647 AI128122 AI123125 AI858611 
    AA669980 BU508082 CB149594 CF128060 BU150049 AA411940 AW513970 BQ722006 
    BP379476 AI016055 AW302626 BM955689 AI278312 CN479901 AL162008 AI637860 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                            
    SP2:              -     -                                       


    ECgene alternative splicing isoforms for CLIC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLIC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLIC4 Expression
    About this image


    CLIC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CLIC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLIC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440544

    UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
    Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression
    is prominent in heart, kidney, placenta and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including CLIC4: 
              Hypertension in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat CLIC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLIC4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic41 , 5 chloride intracellular channel 4 (mitochondrial)1, 5 88.41(n)1
    98.81(a)1
      4 (67.19 cM)5
    298761  NM_013885.21  NP_038913.11 
     1352139695 
    chicken
    (Gallus gallus)
    Aves CLIC41 chloride intracellular channel 4 78.4(n)
    88(a)
      419595  XM_004947724.1  XP_004947781.1 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC46
    chloride intracellular channel 4
    89(a)
    1 ↔ 1
    GL343464.1(102266-114237)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34852 Xenopus laevis chloride intracellular channel protein more 78.41(n)    AY277696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc47b042 Danio rerio mRNA similar to chloride intracellular more 77.12(n)    BC051622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    26(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Protein EXC-4 (exc-4) mRNA, complete cds
    25(a)
    21(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465) WBGene00001371
    I(14512663-14518719) WBGene00001365


    ENSEMBL Gene Tree for CLIC4 (if available)
    TreeFam Gene Tree for CLIC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLIC4 gene
    CLIC62  CLIC32  CLIC12  CLIC52  CLIC22  
    6 SIMAP similar genes for CLIC4 using alignment to 2 protein entries:     CLIC4_HUMAN (see all proteins):
    CLIC6    CLIC5    MST130    CLIC1    CLIC3    CLIC2

    Find genes that share paralogs with CLIC4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CLIC4
    PGOHUM00000234123 PGOHUM00000236413 PGOHUM00000241721


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CLIC4 (see all 1682)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350378471,2
    C--23410367(+) TGAGG-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs1130245741,2
    C,F--25069812(+) GTTCAT/CGATTC 1 -- us2k13Minor allele frequency- C:0.11CSA WA 121
    rs1839696791,2
    --25069897(+) AAGGGA/GAGCCT 1 -- us2k10--------
    rs21851511,2
    C,F,A,H--25069939(+) TAGCCG/AGGCAT 1 -- us2k126Minor allele frequency- A:0.29NS EA NA WA CSA 2706
    rs1866611251,2
    --25069957(+) GTAGAA/CTATGA 1 -- us2k10--------
    rs1410062021,2
    C--25070042(+) AGCACA/GTATGG 1 -- us2k10--------
    rs21531251,2
    C,F,A--25070230(+) AACTTG/ACTTTG 1 -- us2k113Minor allele frequency- A:0.35NA WA CSA EA 375
    rs1501418691,2
    --25070309(+) CTGGTA/GTGTGC 1 -- us2k10--------
    rs1914690421,2
    --25070382(+) CCCAAA/CCTGGG 1 -- us2k10--------
    rs1117444151,2
    C,F--25070477(+) GCCCCC/AGGCAC 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CLIC4 (25071760 - 25170815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CLIC4 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995974CNV Deletion20482838
    esv3809CNV Deletion18987735
    esv2525447CNV Deletion19546169
    esv2082154CNV Deletion18987734
    esv2745530CNV Deletion23290073
    esv995045CNV Deletion20482838
    esv1446144CNV Deletion17803354
    esv7429CNV Loss19470904
    nsv871066CNV Loss21882294
    nsv511684CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLIC4
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606536    OMIM disorders: --

    1 disease for CLIC4:    
    About MalaCards
    pancreatic cancer


    Find genes that share disorders with CLIC4           About GenesLikeMe

    6 Novoseek inferred disease relationships for CLIC4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 59.3 2 17200346 (1), 17443730 (1)
    epithelial tumor 46.4 5 17200346 (1), 17443730 (1)
    necrosis 4.16 1 17200346 (1)
    cancer 3.24 19 17200346 (7), 17443730 (4), 16358817 (1), 19781102 (1)
    breast cancer 0 4 17200346 (2)
    tumors 0 32 17200346 (13), 17443730 (3), 16358817 (1)

    Genetic Association Database (GAD): CLIC4
    Human Genome Epidemiology (HuGE) Navigator: CLIC4 (2 documents)

    Export disorders for CLIC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLIC4 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with CLIC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression. (PubMed id 10070163)1, 2, 3 Edwards J.C. (Am. J. Physiol. 1999)
    2. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PubMed id 17200346)1, 2, 9 Suh K.S.... Yuspa S.H. (Clin. Cancer Res. 2007)
    3. Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. (PubMed id 12163372)1, 2, 9 Ronnov-Jessen L.... Petersen O.W. (Am. J. Pathol. 2002)
    4. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 9 Berryman M. and Bretscher A. (Mol. Biol. Cell 2000)
    5. Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. (PubMed id 16239224)1, 2, 9 Bohman S....Claesson-Welsh L. (J. Biol. Chem. 2005)
    6. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. (PubMed id 19247789)1, 2, 9 Tung J.J.... Kitajewski J. (Angiogenesis 2009)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. (PubMed id 17636002)1, 2 Suh K.S.... Yuspa S.H. (J. Cell Sci. 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25932 HGNC: 13518 AceView: CLIC4 Ensembl:ENSG00000169504 euGenes: HUgn25932
    ECgene: CLIC4 H-InvDB: CLIC4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CLIC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLIC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CLIC4 gene:
    Search GeneIP for patents involving CLIC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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