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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CLIC4 Gene

protein-coding GIFtS: 57
GCID: GC01P025071

chloride intracellular channel 4

Explore 9 diseases affiliated with
CLIC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chloride Intracellular Channel 4¹ ²		DKFZP566G223¹
CLIC4L¹ ²		P64H1¹
H1¹ ²		MTCLIC²
HuH1¹		Chloride Intracellular Channel 4 Like²
P64H1¹		Chloride Intracellular Channel Protein 4²
Intracellular Chloride Ion Channel Protein P64H1² ³

External Ids:	HGNC: 13518¹	Entrez Gene: 25932²	Ensembl: ENSG00000169504⁷	OMIM: 606536⁵	UniProtKB: Q9Y696³

Export aliases for CLIC4 gene to outside databases

Previous GC identifers: GC01P024596 GC01P024141 GC01P024423 GC01P024817 GC01P024944 GC01P023328

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIC4:

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization

of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.

Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene

is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696

Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.

Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing

conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in

angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote

endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)

Gene Wiki entry for CLIC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLIC4 gene promoter:
C/EBPbeta Pax-5 FOXO3b Evi-1 S8 Zic1 FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLIC4 promoter sequence

Search SABiosciences Chromatin IP Primers for CLIC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p

CLIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P025071: view genomic region (about GC identifiers)

Start:	25,071,760 bp from pter	End:	25,170,815 bp from pter
Size:	99,056 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696 (See protein sequence)

Recommended Name: Chloride intracellular channel protein 4

Size: 253 amino acids; 28772 Da

Subunit: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin,

alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin

and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein

(Probable). Nucleus matrix. Cell membrane; Single-pass membrane protein (Probable). Mitochondrion. Cell junction.

Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane

protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely

represent trans-Golgi network vesicles

3 PDB 3D structures from and Proteopedia for CLIC4:

2AHE (3D)

2D2Z (3D)

3OQS (3D)

Secondary accessions: Q9UFW9 Q9UQJ6

Explore the universe of human proteins at neXtProt for CLIC4: NX_Q9Y696

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y696

CLIC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_039234.1

ENSEMBL proteins:

ENSP00000363500 ENSP00000436538

Human Recombinant Protein Products:

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	Novus Biologicals CLIC4 Proteins Novus Biologicals CLIC4 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CLIC4
	Uscn Proteins for CLIC4

Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	IDA	14569596
GO:0005773	vacuole	IEA	--
GO:0005813	centrosome	IDA	14569596

CLIC4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CLIC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLIC4 for domains About GeneDecksing

4 InterPro domains/families:

IPR002946 Int_Cl_channel

IPR012336 Thioredoxin-like_fold

IPR017933 Glutathione_S_Trfase/Cl_chnl_C

IPR010987 Glutathione-S-Trfase_C-like

Graphical View of Domain Structure for InterPro Entry Q9Y696

ProtoNet protein and cluster: Q9Y696

1 Blocks protein family: IPB002946 Intracellular chloride (Cl-) channel signature

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696

Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is

inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is

thought to expose hydrophobic surfaces that trigger membrane insertion

Similarity: Belongs to the chloride channel CLIC family

Similarity: Contains 1 GST C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696

Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.

Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing

conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in

angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote

endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)

Induction: Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts

miRNA Products:		OriGene 3'-UTR Clone: CLIC4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC4
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC4 (see all 44):
		hsa-miR-3194-5p hsa-miR-429 hsa-miR-128 hsa-miR-1258 hsa-miR-29b-1* hsa-miR-502-3p hsa-miR-374c hsa-miR-9

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC4 (see all 7) OriGene shRNA RFP: CLIC4 OriGene siRNA: CLIC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC4

Gene Editing
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		GenScript: all cDNA clones in your preferred vector: CLIC4 (NM_013943)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CLIC4
		Search LifeMap BioReagents cell lines for CLIC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005247	voltage-gated chloride channel activity	IEA	--
GO:0005254	chloride channel activity	TAS	9295337
GO:0005515	protein binding	IPI	12163479

CLIC4 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for CLIC4:

Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Decreased nuclei size in G2M	Large nuclei
Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for CLIC4: Clic4^tm1.1Yus Clic4^tm1Jce Clic4^tm1.1Aidi
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Clic4):

cardiovascular system	growth/size	homeostasis/metabolism	immune system	integument
mortality/aging	reproductive system	vision/eye

CLIC4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

Neuropathic Pain-Signaling in Dorsal Horn Neurons

Cholera Infection

0.40

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC4

	Cholera Infection
	Hepatic ABC Transporters
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CLIC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/11 Interacting proteins for CLIC4 (Q9Y696^{2, 3} ENSP00000363500⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709³, ENSP00000349960⁴	I2D: score=3 STRING: ENSP00000349960
MCC	P23508³, ENSP00000386227⁴	I2D: score=1 STRING: ENSP00000386227
DNM1	Q05193³, ENSP00000362014⁴	I2D: score=3 STRING: ENSP00000362014
YWHAZ	P63104³, ENSP00000309503⁴	I2D: score=3 STRING: ENSP00000309503
PIP5K1B	O14986³	I2D: score=2

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001886	endothelial cell morphogenesis	IEA	--
GO:0006821	chloride transport	NAS	10793131
GO:0007035	vacuolar acidification	IEA	--
GO:0009566	fertilization	IEA	--

CLIC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CLIC4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLIC4

1 HMDB Compound for CLIC4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--

1 Novoseek chemical compound relationship for CLIC4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chloride	75.4	28	12163372 (2), 16239224 (2), 12237120 (1), 17353112 (1) (see all 15)

Search CenterWatch for drugs/clinical trials and news about CLIC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CLIC4 gene:

NM_013943.2

Unigene Clusters for CLIC4:

Chloride intracellular channel 4

Hs.440544 [show with all ESTs], Hs.595507 [show with all ESTs]

Unigene Representative Sequences: NM_013943, AL535796

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374379(uc001bjo.2) ENST00000488683(uc001bjp.1) ENST00000497755

ENST00000489758

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC4
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC4 (see all 44):
		hsa-miR-3194-5p hsa-miR-429 hsa-miR-128 hsa-miR-1258 hsa-miR-29b-1* hsa-miR-502-3p hsa-miR-374c hsa-miR-9

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CLIC4 (NM_013943)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC4
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CLIC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC4

Additional cDNA sequence: Z24749.1

21 DOTS entries:

DT.450018 DT.100879680 DT.100799672 DT.100879681 DT.121399506 DT.97769294 DT.92452587 DT.121399521

DT.121399596 DT.121399511 DT.40123733 DT.92452589 DT.95249991 DT.121399526 DT.100879687 DT.101979659

DT.121399524 DT.121399547 DT.121399560 DT.121399621 DT.121399632

24/683 AceView cDNA sequences (see all 683):

AL698006 AI753101 BC012444 CB132831 BX955857 CB216640 AW513970 AI418273

BQ882124 BM127575 CA415912 AA917861 AW302626 BU150049 AI638420 BU429309

CA416943 AI754996 BQ573930 BE048035 BU508082 AW504226 BQ440240 CR592023

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b
SP1:
SP2:					-		-

ECgene alternative splicing isoforms for CLIC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CLIC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CLIC4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CLIC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLIC4

SOURCE GeneReport for Unigene clusters: Hs.440544 Hs.595507

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696

Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is

prominent in heart, kidney, placenta and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including CLIC4:

Hypertension in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLIC4 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CLIC4¹	chloride intracellular channel 4	81.96(n) 93.94(a)		419595 XM_417741.3 XP_417741.3
lizard (Anolis carolinensis)	Reptilia	CLIC4⁶	--	89(a)	1 ↔ 1	GL343464.1(102266-114237)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3485²	Xenopus laevis chloride intracellular channel protein more	78.41(n)		AY277696.1
zebrafish (Danio rerio)	Actinopterygii	wufc47b04²	Danio rerio mRNA similar to chloride intracellular more	77.12(n)		BC051622.1
fruit fly (Drosophila melanogaster)	Insecta	Clic⁶	Chloride intracellular channel	24(a)	1 → many	X(13707165-13716357)
worm (Caenorhabditis elegans)	Secernentea	exl-1⁶ exc-4⁶	Chloride intracellular channel exc-4	22(a) 20(a)	many ↔ many many ↔ many	II(14412121-14413389) I(14512651-14518707)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATDHAR1⁶ DHAR2⁶ (see all 4)	glutathione S-transferase DHAR2 (see all 4)	25(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	1(6773302-6774528) 1(28250075-28251350)
rice (Oryza sativa)	Liliopsida	-- --	glutathione S-transferase, N-terminal domain conta... glutathione S-transferase, N-terminal domain conta...	20(a) 18(a)	many ↔ many many ↔ many	6(6889586-6894645) 5(876932-880610)

ENSEMBL Gene Tree for CLIC4 (if available)
TreeFam Gene Tree for CLIC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CLIC4 gene

CLIC6² CLIC3² CLIC1² CLIC5² CLIC2²

6 SIMAP similar genes for CLIC4 using alignment to 2 protein entries: CLIC4_HUMAN (see all proteins):

CLIC6 CLIC5 MST130 CLIC1 CLIC3 CLIC2

CLIC4 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for CLIC4
PGOHUM00000234123 PGOHUM00000236413 PGOHUM00000241721

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11249174^1,2		--	23382839(+)	`TCCGCC/TCGGCC`	1	--	int¹		0	--	--	--	--
rs113024574^1,2		--	25069812(+)	`GTTCAT/CGATTC`	1	--	us2k¹		3		CSA WA	121
rs183969679^1,2		--	25069897(+)	`AAGGGA/GAGCCT`	1	--	us2k¹		0	--	--	--	--
rs2185151^1,2	C,F,A,H,	--	25069939(+)	`TAGCCG/AGGCAT`	1	--	us2k¹		26		NS EA NA WA CSA	2706
rs186661125^1,2		--	25069957(+)	`GTAGAA/CTATGA`	1	--	us2k¹		0	--	--	--	--
rs141006202^1,2		--	25070042(+)	`AGCACA/GTATGG`	1	--	us2k¹		0	--	--	--	--
rs2153125^1,2	C,F,A,	--	25070230(+)	`AACTTG/ACTTTG`	1	--	us2k¹		13		NA WA CSA EA	375
rs150141869^1,2		--	25070309(+)	`CTGGTA/GTGTGC`	1	--	us2k¹		0	--	--	--	--
rs191469042^1,2		--	25070382(+)	`CCCAAA/CCTGGG`	1	--	us2k¹		0	--	--	--	--
rs111744415^1,2	C,	--	25070477(+)	`GCCCCC/AGGCAC`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for CLIC4 (25071760 - 25170815 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CLIC4
8 CNVs: 38988 5480 23363 43504 60808 38987 97321 43772

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLIC4 for disorders           About GeneDecksing

OMIM gene information: 606536    OMIM disorders: --

9 diseases for CLIC4:    About MalaCards

pancreatic cancer atopic dermatitis pancreatitis dermatitis

hepatocellular carcinoma seizures ovarian cancer carcinoma

neuronitis

6 Novoseek disease relationships for CLIC4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
stromal tumors	59.3	2	17200346 (1), 17443730 (1)
epithelial tumor	46.4	5	17200346 (1), 17443730 (1)
necrosis	4.16	1	17200346 (1)
cancer	3.24	19	17200346 (7), 17443730 (4), 16358817 (1), 19781102 (1)
breast cancer	0	4	17200346 (2)
tumors	0	32	17200346 (13), 17443730 (3), 16358817 (1)

Human Genome Epidemiology (HuGE) Navigator: CLIC4 (2 documents)

Export disorders for CLIC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CLIC4 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with CLIC4)

Utopia: connect your pdf to the dynamic
world of online information

A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression. (PubMed id 10070163)^{1, 2, 3} Edwards J.C. (1999)
Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PubMed id 17200346)^{1, 2, 9} Suh K.S.... Yuspa S.H. (2007)
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. (PubMed id 12163372)^{1, 2, 9} Ronnov-Jessen L....Petersen O.W. (2002)
Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)^{1, 2, 9} Berryman M. and Bretscher A. (2000)
Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. (PubMed id 16239224)^{1, 2, 9} Bohman S....Claesson-Welsh L. (2005)
Chloride intracellular channel 4 is involved in endot helial proliferation and morphogenesis in vitro. (PubMed id 19247789)^{1, 2, 9} Tung J.J....Kitajewski J. (2009)
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. (PubMed id 17636002)^{1, 2} Suh K.S.... Yuspa S.H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. (PubMed id 14569596)^{1, 2} Berryman M.A. and Goldenring J.R. (2003)
AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. (PubMed id 12163479)^{1, 2} Shanks R.A.... Goldenring J.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25932	HGNC: 13518	AceView: CLIC4	Ensembl:ENSG00000169504	euGenes: HUgn25932
ECgene: CLIC4	H-InvDB: CLIC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CLIC4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CLIC4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CLIC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CLIC4 gene:
Search GeneIP for patents involving CLIC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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chloride intracellular channel 4

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chloride intracellular channel 4

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