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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC4 Gene

protein-coding   GIFtS: 60
GCID: GC01P025071

Chloride Intracellular Channel 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chloride Intracellular Channel 41 2     Chloride Intracellular Channel 4 Like2
Intracellular Chloride Ion Channel Protein P64H12 3     Chloride Intracellular Channel Protein 42
CLIC4L2     huH12
H12     p64H12
MTCLIC2     

External Ids:    HGNC: 135181   Entrez Gene: 259322   Ensembl: ENSG000001695047   OMIM: 6065365   UniProtKB: Q9Y6963   

Export aliases for CLIC4 gene to outside databases

Previous GC identifers: GC01P024596 GC01P024141 GC01P024423 GC01P024817 GC01P024944 GC01P023328


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIC4 Gene:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including
stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and
regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a
member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in
Panc-1 cells (pancreatic cancer cells). (provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC4 Gene: 
CLIC4 (chloride intracellular channel 4) is a protein-coding gene. Diseases associated with CLIC4 include pancreatic cancer, and pancreatitis, and among its related super-pathways are Activation of cAMP-Dependent PKA and MODY (Maturity-Onset Diabetes of Young). GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.
Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under
oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential
role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could
also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)

Gene Wiki entry for CLIC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC4 gene promoter:
         C/EBPbeta   Pax-5   FOXO3b   Evi-1   S8   Zic1   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p

CLIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P025071:  view genomic region     (about GC identifiers)

Start:
25,071,760 bp from pter      End:
25,170,815 bp from pter
Size:
99,056 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 4  
Size: 253 amino acids; 28772 Da
Subunit: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin,
alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin,
tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle
membrane; Single-pass membrane protein (Probable). Nucleus matrix. Cell membrane; Single-pass membrane protein
(Probable). Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both
as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an
intracellular vesicular compartment that likely represent trans-Golgi network vesicles
3 PDB 3D structures from and Proteopedia for CLIC4:
2AHE (3D)        2D2Z (3D)        3OQS (3D)    
Secondary accessions: Q9UFW9 Q9UQJ6

Explore the universe of human proteins at neXtProt for CLIC4: NX_Q9Y696

Explore proteomics data for CLIC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y696

  • CLIC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLIC4 Protein Expression
    REFSEQ proteins: NP_039234.1  
    ENSEMBL proteins: 
     ENSP00000363500   ENSP00000436538  

    Human Recombinant Protein Products for CLIC4: 
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    ProSpec Recombinant Protein for CLIC4
    Cloud-Clone Corp. Proteins for CLIC4 

    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA14569596
    GO:0005773vacuole ----
    GO:0005813centrosome IDA14569596

    CLIC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q9Y696

    ProtoNet protein and cluster: Q9Y696

    1 Blocks protein domain: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    CLIC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC4_HUMAN, Q9Y696
    Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.
    Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under
    oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential
    role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could
    also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis)
    Induction: Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity TAS9295337
    GO:0005515protein binding IPI10793131
         
    CLIC4 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CLIC4:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M  Large nuclei 
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Clic4):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  integument 
     mortality/aging  reproductive system  vision/eye 

    CLIC4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CLIC4: Clic4tm1.1Yus Clic4tm1Jce Clic4tm1.1Aidi

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLIC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLIC4

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLIC4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    4Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC4
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 Cell Signaling Technology (CST) Pathway for CLIC4
        Glucose / Energy Metabolism




    CLIC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for CLIC4 (Q9Y6962, 3 ENSP000003635004) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=3 STRING: ENSP00000349960
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    DNM1Q051933, ENSP000003620144I2D: score=3 STRING: ENSP00000362014
    YWHAZP631043, ENSP000003095034I2D: score=3 STRING: ENSP00000309503
    PIP5K1BO149863I2D: score=2 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0006821chloride transport NAS10793131
    GO:0007035vacuolar acidification IEA--
    GO:0009566fertilization IEA--

    CLIC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIC4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CLIC4

    1 HMDB Compound for CLIC4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 Novoseek inferred chemical compound relationship for CLIC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 75.4 28 12163372 (2), 16239224 (2), 12237120 (1), 17353112 (1) (see all 15)

    Search CenterWatch for drugs/clinical trials and news about CLIC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLIC4 gene: 
    NM_013943.2  

    Unigene Cluster for CLIC4:

    Chloride intracellular channel 4
    Hs.440544  [show with all ESTs]
    Unigene Representative Sequence: NM_013943
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374379(uc001bjo.2) ENST00000497755 ENST00000488683(uc001bjp.1)
    ENST00000489758
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    Additional mRNA sequence: 

    AF097330.1 AF109196.1 AK001624.1 AK095959.1 AK301466.1 AK307142.1 AK308909.1 AK315051.1 
    AL080061.1 AL117424.1 AL162008.1 BC012444.1 CR533501.1 Z24740.1 Z24749.1 

    21 DOTS entries:

    DT.450018  DT.100879680  DT.100799672  DT.100879681  DT.121399506  DT.97769294  DT.92452587  DT.121399521 
    DT.121399596  DT.121399511  DT.40123733  DT.92452589  DT.95249991  DT.121399526  DT.100879687  DT.101979659 
    DT.121399524  DT.121399547  DT.121399560  DT.121399621  DT.121399632 

    24/683 AceView cDNA sequences (see all 683):

    BP378562 BQ226650 AL162008 AI889720 AA232489 BU429309 AU132897 AI277669 
    CB149594 Z24740 AI123125 AI554222 AW513970 CR592023 BQ224192 AI754339 
    AW338291 BU430618 AI373119 BQ882124 CB216640 AI278312 AW611575 BF054977 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                            
    SP2:              -     -                                       


    ECgene alternative splicing isoforms for CLIC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC4 expression in normal human tissues (normalized intensities)      CLIC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CLIC4 Expression
    About this image


    CLIC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   
             trachea   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             colon ; endothelial cells   
             blood vessel   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See CLIC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC4

    SOURCE GeneReport for Unigene cluster: Hs.440544

    UniProtKB/Swiss-Prot: CLIC4_HUMAN, Q9Y696
    Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression
    is prominent in heart, kidney, placenta and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including CLIC4: 
              Hypertension in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CLIC4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic41 , 5 chloride intracellular channel 4 (mitochondrial)1, 5 88.41(n)1
    98.81(a)1
      4 (67.19 cM)5
    298761  NM_013885.21  NP_038913.11 
     1352139695 
    chicken
    (Gallus gallus)
    Aves CLIC41 chloride intracellular channel 4 81.96(n)
    93.94(a)
      419595  XM_417741.3  XP_417741.3 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC46
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343464.1(102266-114237)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34852 Xenopus laevis chloride intracellular channel protein more 78.41(n)    AY277696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc47b042 Danio rerio mRNA similar to chloride intracellular more 77.12(n)    BC051622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    25(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Chloride intracellular channel exc-4
    26(a)
    19(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465)
    I(14512663-14518719)


    ENSEMBL Gene Tree for CLIC4 (if available)
    TreeFam Gene Tree for CLIC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC4 gene
    CLIC62  CLIC32  CLIC12  CLIC52  CLIC22  
    6 SIMAP similar genes for CLIC4 using alignment to 2 protein entries:     CLIC4_HUMAN (see all proteins):
    CLIC6    CLIC5    MST130    CLIC1    CLIC3    CLIC2

    CLIC4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CLIC4
    PGOHUM00000234123 PGOHUM00000236413 PGOHUM00000241721


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1682 SNPs in CLIC4 are shown (see all 1682)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350378471,2
    C--23410367(+) TGAGG-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs1130245741,2
    C,F--25069812(+) GTTCAT/CGATTC 1 -- us2k13Minor allele frequency- C:0.11CSA WA 121
    rs1839696791,2
    --25069897(+) AAGGGA/GAGCCT 1 -- us2k10--------
    rs21851511,2
    C,F,A,H--25069939(+) TAGCCG/AGGCAT 1 -- us2k126Minor allele frequency- A:0.29NS EA NA WA CSA 2706
    rs1866611251,2
    --25069957(+) GTAGAA/CTATGA 1 -- us2k10--------
    rs1410062021,2
    C--25070042(+) AGCACA/GTATGG 1 -- us2k10--------
    rs21531251,2
    C,F,A--25070230(+) AACTTG/ACTTTG 1 -- us2k113Minor allele frequency- A:0.35NA WA CSA EA 375
    rs1501418691,2
    --25070309(+) CTGGTA/GTGTGC 1 -- us2k10--------
    rs1914690421,2
    --25070382(+) CCCAAA/CCTGGG 1 -- us2k10--------
    rs1117444151,2
    C,F--25070477(+) GCCCCC/AGGCAC 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CLIC4 (25071760 - 25170815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for CLIC4 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv995974CNV Deletion20482838
    esv3809CNV Deletion18987735
    esv2525447CNV Deletion19546169
    esv2082154CNV Deletion18987734
    esv2745530CNV Deletion23290073
    esv995045CNV Deletion20482838
    esv1446144CNV Deletion17803354
    esv7429CNV Loss19470904
    nsv871066CNV Loss21882294
    nsv511684CNV Loss21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606536    OMIM disorders: --

    10 diseases for CLIC4:    About MalaCards
    pancreatic cancer    pancreatitis    atopic dermatitis    dermatitis
    cholera    endotheliitis    hypertension    ovarian cancer
    hepatitis    neuronitis


    CLIC4 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CLIC4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 59.3 2 17200346 (1), 17443730 (1)
    epithelial tumor 46.4 5 17200346 (1), 17443730 (1)
    necrosis 4.16 1 17200346 (1)
    cancer 3.24 19 17200346 (7), 17443730 (4), 16358817 (1), 19781102 (1)
    breast cancer 0 4 17200346 (2)
    tumors 0 32 17200346 (13), 17443730 (3), 16358817 (1)

    Genetic Association Database (GAD): CLIC4
    Human Genome Epidemiology (HuGE) Navigator: CLIC4 (2 documents)

    Export disorders for CLIC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC4 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with CLIC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression. (PubMed id 10070163)1, 2, 3 Edwards J.C. (1999)
    2. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PubMed id 17200346)1, 2, 9 Suh K.S.... Yuspa S.H. (2007)
    3. Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. (PubMed id 12163372)1, 2, 9 Ronnov-Jessen L....Petersen O.W. (2002)
    4. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 9 Berryman M. and Bretscher A. (2000)
    5. Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. (PubMed id 16239224)1, 2, 9 Bohman S....Claesson-Welsh L. (2005)
    6. Chloride intracellular channel 4 is involved in endot helial proliferation and morphogenesis in vitro. (PubMed id 19247789)1, 2, 9 Tung J.J....Kitajewski J. (2009)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. (PubMed id 17636002)1, 2 Suh K.S.... Yuspa S.H. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25932 HGNC: 13518 AceView: CLIC4 Ensembl:ENSG00000169504 euGenes: HUgn25932
    ECgene: CLIC4 H-InvDB: CLIC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLIC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLIC4 gene:
    Search GeneIP for patents involving CLIC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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