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Aliases for CLIC4 Gene

Aliases for CLIC4 Gene

  • Chloride Intracellular Channel 4 2 3 5
  • Intracellular Chloride Ion Channel Protein P64H1 3 4
  • Chloride Intracellular Channel 4 Like 3
  • CLIC4L 3
  • MTCLIC 3
  • P64H1 3
  • HuH1 3
  • H1 3

External Ids for CLIC4 Gene

Previous GeneCards Identifiers for CLIC4 Gene

  • GC01P024596
  • GC01P024141
  • GC01P024423
  • GC01P024817
  • GC01P024944
  • GC01P025071
  • GC01P023328

Summaries for CLIC4 Gene

Entrez Gene Summary for CLIC4 Gene

  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC4 Gene

CLIC4 (Chloride Intracellular Channel 4) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC1.

UniProtKB/Swiss-Prot for CLIC4 Gene

  • Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Gene Wiki entry for CLIC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC4 Gene

Genomics for CLIC4 Gene

Regulatory Elements for CLIC4 Gene

Enhancers for CLIC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CLIC4 on UCSC Golden Path with GeneCards custom track

Promoters for CLIC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLIC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLIC4 Gene

Chromosome:
1
Start:
24,745,269 bp from pter
End:
24,844,324 bp from pter
Size:
99,056 bases
Orientation:
Plus strand

Genomic View for CLIC4 Gene

Genes around CLIC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC4 Gene

Proteins for CLIC4 Gene

  • Protein details for CLIC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y696-CLIC4_HUMAN
    Recommended name:
    Chloride intracellular channel protein 4
    Protein Accession:
    Q9Y696
    Secondary Accessions:
    • Q9UFW9
    • Q9UQJ6

    Protein attributes for CLIC4 Gene

    Size:
    253 amino acids
    Molecular mass:
    28772 Da
    Quaternary structure:
    • Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9.

    Three dimensional structures from OCA and Proteopedia for CLIC4 Gene

neXtProt entry for CLIC4 Gene

Proteomics data for CLIC4 Gene at MOPED

Post-translational modifications for CLIC4 Gene

  • Ubiquitination at Lys 62, Lys 146, Lys 199, and Lys 212
  • Modification sites at PhosphoSitePlus

Other Protein References for CLIC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CLIC4 Gene

Domains & Families for CLIC4 Gene

Gene Families for CLIC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y696

UniProtKB/Swiss-Prot:

CLIC4_HUMAN :
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Belongs to the chloride channel CLIC family.
Domain:
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC4: view

Function for CLIC4 Gene

Molecular function for CLIC4 Gene

UniProtKB/Swiss-Prot Function:
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
UniProtKB/Swiss-Prot Induction:
Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.
genes like me logo Genes that share phenotypes with CLIC4: view

Animal Models for CLIC4 Gene

MGI Knock Outs for CLIC4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLIC4

miRNA for CLIC4 Gene

miRTarBase miRNAs that target CLIC4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLIC4 Gene

Localization for CLIC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIC4 Gene COMPARTMENTS Subcellular localization image for CLIC4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 14569596
GO:0005813 centrosome IDA 14569596
GO:0005886 plasma membrane IDA 19776349
GO:0005911 cell-cell junction IDA 14569596
GO:0030496 midbody IDA 14569596
genes like me logo Genes that share ontologies with CLIC4: view

Pathways & Interactions for CLIC4 Gene

genes like me logo Genes that share pathways with CLIC4: view

Pathways by source for CLIC4 Gene

1 Cell Signaling Technology pathway for CLIC4 Gene

Gene Ontology (GO) - Biological Process for CLIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0006749 NOT glutathione metabolic process IBA --
GO:0006915 apoptotic process IEA --
GO:0007035 vacuolar acidification IEA --
GO:0030216 keratinocyte differentiation IMP 17636002
genes like me logo Genes that share ontologies with CLIC4: view

No data available for SIGNOR curated interactions for CLIC4 Gene

Drugs & Compounds for CLIC4 Gene

(2) Additional Compounds for CLIC4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with CLIC4: view

Transcripts for CLIC4 Gene

Unigene Clusters for CLIC4 Gene

Chloride intracellular channel 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -

Relevant External Links for CLIC4 Gene

GeneLoc Exon Structure for
CLIC4
ECgene alternative splicing isoforms for
CLIC4

Expression for CLIC4 Gene

mRNA expression in normal human tissues for CLIC4 Gene

mRNA differential expression in normal tissues according to GTEx for CLIC4 Gene

This gene is overexpressed in Artery - Tibial (x5.1) and Artery - Aorta (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIC4 Gene



SOURCE GeneReport for Unigene cluster for CLIC4 Gene Hs.440544

mRNA Expression by UniProt/SwissProt for CLIC4 Gene

Q9Y696-CLIC4_HUMAN
Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with CLIC4: view

Protein tissue co-expression partners for CLIC4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for CLIC4 Gene

Orthologs for CLIC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLIC4 35
  • 94.73 (n)
  • 98.81 (a)
CLIC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIC4 35
  • 95.52 (n)
  • 98.42 (a)
CLIC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clic4 35
  • 88.41 (n)
  • 98.81 (a)
Clic4 16
Clic4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLIC4 35
  • 99.87 (n)
  • 100 (a)
CLIC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clic4 35
  • 88.93 (n)
  • 97.63 (a)
oppossum
(Monodelphis domestica)
Mammalia CLIC4 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIC4 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLIC4 35
  • 78.4 (n)
  • 88 (a)
CLIC4 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIC4 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clic5 35
  • 76.46 (n)
  • 86.51 (a)
Str.20225 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3485 35
zebrafish
(Danio rerio)
Actinopterygii clic4 35
  • 75 (n)
  • 86.11 (a)
wufc47b04 35
clic4 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 21 (a)
ManyToMany
exl-1 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2986 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 46 (a)
OneToMany
Species with no ortholog for CLIC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLIC4 Gene

ENSEMBL:
Gene Tree for CLIC4 (if available)
TreeFam:
Gene Tree for CLIC4 (if available)

Paralogs for CLIC4 Gene

Paralogs for CLIC4 Gene

(6) SIMAP similar genes for CLIC4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CLIC4 Gene

genes like me logo Genes that share paralogs with CLIC4: view

Variants for CLIC4 Gene

Sequence variations from dbSNP and Humsavar for CLIC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9259 -- 24,841,633(-) AAAAC(C/G)CTCAC utr-variant-3-prime
rs12439 -- 24,843,143(+) TGTCT(A/G)TTGTG utr-variant-3-prime
rs1139995 -- 24,844,269(-) TATCA(A/T)AAAGG utr-variant-3-prime
rs1890449 -- 24,749,310(-) ATACC(A/G/T)CTTGG intron-variant
rs1981195 -- 24,766,982(+) aatta(C/T)cttgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC4 Gene

Variant ID Type Subtype PubMed ID
nsv870740 CNV Gain 21882294
nsv522437 CNV Gain 19592680
nsv871066 CNV Loss 21882294
nsv871535 CNV Loss 21882294
nsv7076 CNV Loss 18451855
esv2525447 CNV Deletion 19546169
esv2082154 CNV Deletion 18987734
nsv511684 CNV Loss 21212237
esv3809 CNV Deletion 18987735
esv2745530 CNV Deletion 23290073
nsv498666 CNV Loss 21111241
esv995974 CNV Deletion 20482838
esv1446144 CNV Deletion 17803354
esv995045 CNV Deletion 20482838
nsv160319 CNV Loss 16902084
esv7429 CNV Loss 19470904

Variation tolerance for CLIC4 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CLIC4 Gene

Disorders for CLIC4 Gene

Relevant External Links for CLIC4

Genetic Association Database (GAD)
CLIC4
Human Genome Epidemiology (HuGE) Navigator
CLIC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLIC4

No disorders were found for CLIC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIC4 Gene

Publications for CLIC4 Gene

  1. A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression. (PMID: 10070163) Edwards J.C. (Am. J. Physiol. 1999) 2 3 4 67
  2. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. (PMID: 19247789) Tung J.J. … Kitajewski J. (Angiogenesis 2009) 3 23
  3. CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. (PMID: 19639201) Yao Q. … Kong B. (Oncol. Rep. 2009) 3 23
  4. S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. (PMID: 19713532) Spiekerkoetter E. … Rabinovitch M. (Circ. Res. 2009) 3 23
  5. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. (PMID: 17200346) Suh K.S. … Yuspa S.H. (Clin. Cancer Res. 2007) 3 23

Products for CLIC4 Gene

Sources for CLIC4 Gene

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