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CLIC3 Gene

protein-coding   GIFtS: 53
GCID: GC09M139889

Chloride Intracellular Channel 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chloride Intracellular Channel 31 2
Chloride Intracellular Channel Protein 32

External Ids:    HGNC: 20641   Entrez Gene: 90222   Ensembl: ENSG000001695837   OMIM: 6065335   UniProtKB: O958333   

Export aliases for CLIC3 gene to outside databases

Previous GC identifers: GC09P131140 GC09M131578 GC09M133330 GC09M135246 GC09M137164 GC09M139008 GC09M109348


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLIC3 Gene:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including
stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and
regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly
localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate
in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CLIC3 Gene:
CLIC3 (chloride intracellular channel 3) is a protein-coding gene. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
Function: Can insert into membranes and form chloride ion channels. May participate in cellular growth control

Gene Wiki entry for CLIC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLIC3 gene promoter:
         Egr-3   Elk-1   Sp1   HTF   Olf-1   Tal-1beta   GATA-2   Egr-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC3 promoter sequence
   Search Chromatin IP Primers for CLIC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLIC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

CLIC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139889:  view genomic region     (about GC identifiers)

Start:
139,889,060 bp from pter      End:
139,891,255 bp from pter
Size:
2,196 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 3  
Size: 236 amino acids; 26648 Da
Subunit: Associated with the C-terminal of ERK7
Sequence caution: Sequence=AAD16450.1; Type=Frameshift; Positions=28;
2 PDB 3D structures from and Proteopedia for CLIC3:
3FY7 (3D)        3KJY (3D)    
Secondary accessions: Q5SPZ7

Explore the universe of human proteins at neXtProt for CLIC3: NX_O95833

Explore proteomics data for CLIC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CLIC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004660.2  
    ENSEMBL proteins: 
     ENSP00000419378  

    CLIC3 Human Recombinant Protein Products:

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    antibodies-online proteins for CLIC3 (9 products) 

     
    antibodies-online peptides for CLIC3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O95833

    ProtoNet protein and cluster: O95833

    2 Blocks protein domains:
    IPB002946 Intracellular chloride (Cl-) channel signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Find genes that share domains with CLIC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC3_HUMAN, O95833
    Function: Can insert into membranes and form chloride ion channels. May participate in cellular growth control

         Genatlas biochemistry entry for CLIC3:
    membrane chloride intracellular channel 3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity IMP9880541
    GO:0005515protein binding IPI9880541
         
    Find genes that share ontologies with CLIC3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CLIC3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLIC3
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    miRNA
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    miRTarBase miRNAs that target CLIC3:
    hsa-mir-124-3p (MIRT022269), hsa-mir-335-5p (MIRT017007)

    Block miRNA regulation of human, mouse, rat CLIC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CLIC3:
    hsa-miR-1197
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CLIC3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLIC3_HUMAN, O95833: Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some
    protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with
    probably a single transmembrane domain (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CLIC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLIC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLIC3
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CLIC3
    Interactions:

        Search GeneGlobe Interaction Network for CLIC3

    2 Interacting proteins for CLIC3 (O958333) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK15Q8TD083I2D: score=2 
    DNM1Q051933I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IMP9880541
    GO:0007165signal transduction TAS9880541
    GO:1902476chloride transmembrane transport IMP9880541

    Find genes that share ontologies with CLIC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLIC3

    1 HMDB Compound for CLIC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 Novoseek inferred chemical compound relationship for CLIC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 66.9 11 17027078 (3), 9880541 (3), 11146166 (1), 20383337 (1) (see all 5)



    Find genes that share compounds with CLIC3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CLIC3 gene: 
    NM_004669.2  

    Unigene Cluster for CLIC3:

    Chloride intracellular channel 3
    Hs.64746  [show with all ESTs]
    Unigene Representative Sequence: BQ960229
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480181 ENST00000494426(uc004ckj.1) ENST00000473911
    miRNA
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    hsa-miR-1197
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AF102166.1 BC007012.1 CR542066.1 

    5 DOTS entries:

    DT.449492  DT.95078791  DT.91681857  DT.91681860  DT.91681859 

    Selected AceView cDNA sequences (see all 78):

    BX351993 BE902774 BI908196 NM_004669 AI760268 BX373661 BI090345 CR619171 
    BM974811 AI354288 CB998146 BC007012 BM043659 AI868502 BX117753 BG336380 
    AA418248 CR542066 BI257750 BG623429 BF028781 BE880878 AI082067 AI241881 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLIC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCTGCTCC
    CLIC3 Expression
    About this image


    CLIC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
    CLIC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLIC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.64746

    UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
    Tissue specificity: Detected in placenta (at protein level). Widely expressed. High expression is found in
    placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CLIC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic31 , 5 chloride intracellular channel 31, 5 83.76(n)1
    91.1(a)1
      2 (17.27 cM)5
    694541  NM_027085.31  NP_081361.11 
     254568385 
    chicken
    (Gallus gallus)
    Aves LOC4172931 chloride intracellular channel protein 3-like 74.67(n)
    72.49(a)
      417293  XM_003642249.2  XP_003642297.2 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC36
    chloride intracellular channel 3
    67(a)
    1 ↔ 1
    GL343888.1(103990-113091)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF376315.12   -- 74(n)    CF376315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clica1 chloride intracellular channel a 59.53(n)
    60.7(a)
      84040  NM_199524.1  NP_955818.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    21(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Protein EXC-4 (exc-4) mRNA, complete cds
    23(a)
    17(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465) WBGene00001371
    I(14512663-14518719) WBGene00001365


    ENSEMBL Gene Tree for CLIC3 (if available)
    TreeFam Gene Tree for CLIC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CLIC3 gene
    CLIC62  CLIC12  CLIC52  CLIC22  CLIC42  
    6 SIMAP similar genes for CLIC3 using alignment to 3 protein entries:     CLIC3_HUMAN (see all proteins):
    MST130    CLIC4    CLIC5    CLIC6    CLIC1    CLIC2

    Find genes that share paralogs with CLIC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLIC3 (see all 114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123792851,2
    C--139888969(+) CCCGAC/ACCCCG 1 -- ds50013Minor allele frequency- A:0.25NA EA 242
    rs1118102061,2
    C,F--139888986(+) CTGCCC/TCTGTG 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1389478871,2
    C,F--139889141(+) GCGGGG/AGTGCA 2 /P /S mis11Minor allele frequency- A:0.00NA 2802
    rs1494174901,2
    C,F--139889162(+) GTAGGC/ACGCCA 2 /A /S mis12Minor allele frequency- A:0.01NA EU 3665
    rs31887221,2
    C,F,H--139889216(-) GCGCGA/CTGCAG 2 M L mis110Minor allele frequency- C:0.04NS NA WA 3830
    rs2018382651,2
    --139889330(+) TGCCGC/TCCCCC 1 -- int10--------
    rs111459651,2
    C--139889385(+) ACGTCA/GACGAT 2 V syn10--------
    rs111459661,2
    C--139889388(+) TCGACG/TATGTG 2 I syn1 ese30--------
    rs1115059701,2
    C--139889409(+) AGGAGG/ACTGCA 2 /S syn12Minor allele frequency- A:0.10WA 120
    rs2009593841,2
    C--139889618(+) ACCCGA/CCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLIC3 (139889060 - 139891255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CLIC3 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    nsv894513CNV Loss21882294
    nsv894483CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8428n71CNV Loss21882294
    nsv894521CNV Loss21882294
    nsv894503CNV Loss21882294
    nsv894546CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894469CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLIC3
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606533    OMIM disorders: --


    Find genes that share disorders with CLIC3           About GenesLikeMe


    Export disorders for CLIC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLIC3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CLIC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. (PubMed id 9880541)1, 2, 3, 9 Qian Z.... Rosner M.R. (J. Biol. Chem. 1999)
    2. Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes. (PubMed id 17027078)1, 2, 9 Money T.T....Gude N.M. (Placenta 2007)
    3. Structure of human CLIC3 at 2 A resolution. (PubMed id 20146363)1, 2 Littler D.R.... Curmi P.M. (Proteins 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies. (PubMed id 22795578)1 Murthi P....Gude N.M. (Placenta 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9022 HGNC: 2064 AceView: CLIC3 Ensembl:ENSG00000169583 euGenes: HUgn9022
    ECgene: CLIC3 H-InvDB: CLIC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLIC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLIC3 gene:
    Search GeneIP for patents involving CLIC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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