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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC3 Gene

protein-coding   GIFtS: 52
GCID: GC09M139889

chloride intracellular channel 3
 Explore 1 disease affiliated with
CLIC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CLIC3    

Aliases
for CLIC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chloride Intracellular Channel 31 2
Chloride Intracellular Channel Protein 32

External Ids:    HGNC: 20641   Entrez Gene: 90222   Ensembl: ENSG000001695837   OMIM: 6065335   UniProtKB: O958333   

Export aliases for CLIC3 gene to outside databases

Previous GC identifers: GC09P131140 GC09M131578 GC09M133330 GC09M135246 GC09M137164 GC09M139008 GC09M109348


Summaries
for CLIC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CLIC3:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization
of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.
Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and
stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based
on its association with ERK7, a member of the MAP kinase family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
Function: Can insert into membranes and form chloride ion channels. May participate in cellular growth control

Gene Wiki entry for CLIC3


Genomic Views
for CLIC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC3 gene promoter:
         Egr-3   Elk-1   Sp1   HTF   Olf-1   Tal-1beta   GATA-2   Egr-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CLIC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

CLIC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139889:  view genomic region     (about GC identifiers)

Start:
 139,889,060 bp from pter      End:
 139,891,255 bp from pter
Size:
 2,196 bases      Orientation:
 minus strand

Proteins
for CLIC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 3  
Size: 236 amino acids; 26648 Da
Subunit: Associated with the C-terminal of ERK7
Subcellular location: Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some
protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a
single transmembrane domain (By similarity)
Sequence caution: Sequence=AAD16450.1; Type=Frameshift; Positions=28;
2 PDB 3D structures from and Proteopedia for CLIC3:
3FY7 (3D)        3KJY (3D)    
Secondary accessions: Q5SPZ7

Explore the universe of human proteins at neXtProt for CLIC3: NX_O95833

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95833

    • CLIC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004660.2  
    ENSEMBL proteins: 
     ENSP00000419378   ENSP00000407100  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CLIC3
    OriGene Protein Over-expression Lysate: CLIC3
    OriGene Custom Protein Services for CLIC3 
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    Novus Biologicals CLIC3 Proteins
    Novus Biologicals CLIC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CLIC3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA9880541
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--


    CLIC3 for ontologies           About GeneDecksing



    CLIC3 Antibody Products: 
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    Uscn ELISAs and CLIAs for CLIC3

    Protein Domains /
    Families
    for CLIC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CLIC3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O95833

    ProtoNet protein and cluster: O95833

    2 Blocks protein families:
    IPB002946 Intracellular chloride (Cl-) channel signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Function
    for CLIC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
    Function: Can insert into membranes and form chloride ion channels. May participate in cellular growth control

         Genatlas biochemistry entry for CLIC3:
    membrane chloride intracellular channel 3

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLIC3:
    hsa-miR-1197
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC3 (see all 7)
    OriGene shRNA RFP: CLIC3
    OriGene siRNA: CLIC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CLIC3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC3 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLIC3 (NM_004669)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC3 

    Cell Line
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    Search LifeMap BioReagents cell lines for CLIC3

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CLIC3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity IMP9880541
    GO:0005515protein binding IPI9880541


    CLIC3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CLIC3:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for CLIC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC3
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLIC3

    2 Interacting proteins for CLIC3 (O958333) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK15Q8TD083I2D: score=2 
    DNM1Q051933I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IMP9880541
    GO:0007165signal transduction TAS9880541


    CLIC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CLIC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIC3

    1 HMDB Compound for CLIC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    1 Novoseek chemical compound relationship for CLIC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 66.9 11 17027078 (3), 9880541 (3), 11146166 (1), 20383337 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about CLIC3 

    Transcripts
    for CLIC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CLIC3 gene: 
    NM_004669.2  

    Unigene Cluster for CLIC3:

    Chloride intracellular channel 3
    Hs.64746  [show with all ESTs]
    Unigene Representative Sequence: BQ960229
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480181 ENST00000494426(uc004ckj.1) ENST00000473911 ENST00000456673


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CLIC3:
    hsa-miR-1197
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC3 (see all 7)
    OriGene shRNA RFP: CLIC3
    OriGene siRNA: CLIC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CLIC3 (NM_004669)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC3

    Additional cDNA sequence: 

    AF102166.1 BC007012.1 CR542066.1 

    5 DOTS entries:

    DT.449492  DT.95078791  DT.91681857  DT.91681860  DT.91681859 

    24/78 AceView cDNA sequences (see all 78):

    BE902774 BI090345 BI908196 CR619171 AI760268 BM974811 BX373661 NM_004669 
    BX351993 BE615216 CR542066 AI192718 CB998146 BV203521 R31051 AI354288 
    AI342187 BE880878 BG480428 BG336380 AI241881 BC007012 W20424 AI741256 

    GeneLoc Exon Structure


    Expression
    for CLIC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCTGCTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CLIC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPodocytesKidney
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Alveolar type II cells (Derivation of mature...)Lung
    HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See CLIC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC3

    SOURCE GeneReport for Unigene cluster: Hs.64746

    UniProtKB/Swiss-Prot: CLIC3_HUMAN, O95833
    Tissue specificity: Detected in placenta (at protein level). Widely expressed. High expression is found in placenta
    followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas

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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CLIC3

    Orthologs
    for CLIC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC3 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Clic31 , 5 chloride intracellular channel 31, 5 83.76(n)1
    91.1(a)1    		   2 (17.27 cM)5
    694541  NM_027085.31  NP_081361.11 
     254568385 
    chicken
    (Gallus gallus)    		 Aves LOC4172931 chloride intracellular channel protein 3-like 74.67(n)
    72.49(a)    		   417293  XM_003642249.1  XP_003642297.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CLIC36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343888.1(103990-113091)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia CF376315.12   -- 74(n)    CF376315.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii clica1 chloride intracellular channel a 59.53(n)
    60.7(a)    		   84040  NM_199524.1  NP_955818.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Clic6
    		 Chloride intracellular channel
    		 21(a)
    		 1 → many
    		 X(13707165-13716357)
    worm
    (Caenorhabditis elegans)    		 Secernentea exl-16
    exc-46
    		 Chloride intracellular channel exc-4
    		 21(a)
    18(a)
    		 many ↔ many
    many ↔ many
    		 II(14412121-14413389)
    I(14512651-14518707)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DHAR26
    ATDHAR16
    (see all 4)    		 glutathione S-transferase DHAR1
    (see all 4)    		 24(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(28250075-28251350)
    1(6773302-6774528)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 glutathione S-transferase, N-terminal domain conta...
    glutathione S-transferase, N-terminal domain conta...
    		 21(a)
    19(a)
    		 many ↔ many
    many ↔ many
    		 6(6889586-6894645)
    5(876932-880610)


    ENSEMBL Gene Tree for CLIC3 (if available)
    TreeFam Gene Tree for CLIC3 (if available) 

    Paralogs
    for CLIC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC3 gene
    CLIC62  CLIC12  CLIC52  CLIC22  CLIC42  
    6 SIMAP similar genes for CLIC3 using alignment to 3 protein entries:     CLIC3_HUMAN (see all proteins):
    MST130    CLIC4    CLIC5    CLIC6    CLIC1    CLIC2

    CLIC3 for paralogs           About GeneDecksing



    Genomic Variants
    for CLIC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 NCBI SNPs in CLIC3 are shown (see all 85)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs775449051,2
    		F,--139888621(+) CCAGCC/TCAGGA 2 -- int1 ds50011Minor allele frequency- T:0.07WA 118
    rs748571061,2
    		--139888698(+) CAGGCC/TGCACC 2 -- ds5001 int12Minor allele frequency- T:0.07NA 122
    rs78658491,2
    		C,H,--139888883(+) GCCCAA/GTCCGG 2 -- ds5001 int112Minor allele frequency- G:0.02NA WA CSA EA 374
    rs123792851,2
    		C,--139888969(+) CCCGAC/ACCCCG 1 -- ds50013Minor allele frequency- A:0.25NA EA 242
    rs1118102061,2
    		C,--139888986(+) CTGCCC/TCTGTG 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1389478871,2
    		C,F,--139889141(+) GCGGGG/AGTGCA 2 /P /S mis11Minor allele frequency- A:0.00NA 2802
    rs1494174901,2
    		C,F,--139889162(+) GTAGGC/ACGCCA 2 /A /S mis12Minor allele frequency- A:0.01NA EU 3665
    rs31887221,2
    		C,F,H,--139889216(-) GCGCGA/CTGCAG 2 M L mis110Minor allele frequency- C:0.04NS NA WA 3830
    rs2018382651,2
    		--139889330(+) TGCCGC/TCCCCC 1 -- int10--------
    rs111459651,2
    		C--139889385(+) ACGTCA/GACGAT 2 V syn10--------

    HapMap Linkage Disequilibrium report for CLIC3 (139889060 - 139891255 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CLIC3
         3 CNVs: 9631 30350 5415

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    Disorders / Diseases
    for CLIC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CLIC3 for disorders           About GeneDecksing

    OMIM gene information: 606533    OMIM disorders: --

    1 disease for CLIC3:    About MalaCards
    neuronitis


    Export disorders for CLIC3 gene to outside databases

    Publications
    for CLIC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CLIC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. (PubMed id 9880541)1, 2, 3, 9 Qian Z.... Rosner M.R. (1999)
    2. Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes. (PubMed id 17027078)1, 2, 9 Money T.T....Gude N.M. (2007)
    3. Structure of human CLIC3 at 2 A resolution. (PubMed id 20146363)1, 2 Littler D.R.... Curmi P.M. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Placental CLIC3 is increased in fetal growth restricti on and pre-eclampsia affected human pregnancies. (PubMed id 22795578)1 Murthi P....Gude N.M. (2012)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)

    External Searches for CLIC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CLIC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9022 HGNC: 2064 AceView: CLIC3 Ensembl:ENSG00000169583 euGenes: HUgn9022
    ECgene: CLIC3 H-InvDB: CLIC3

    Other Databases showing CLIC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CLIC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CLIC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CLIC3 gene:
    Search GeneIP for patents involving CLIC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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