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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC2 Gene

protein-coding   GIFtS: 54
GCID: GC0XM154505

chloride intracellular channel 2

 Explore 3 diseases affiliated with
CLIC2 via our new
 Human Malady Compendium 
Biological research products
for CLIC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chloride Intracellular Channel 21 2
XAP1211 2 3
CLIC2b2
MRXS322
Chloride Intracellular Channel Protein 22

External Ids:    HGNC: 20631   Entrez Gene: 11932   Ensembl: ENSG000001559627   OMIM: 3001385   UniProtKB: O152473   

Export aliases for CLIC2 gene to outside databases

Previous GC identifers: GC0XP148554 GC0XP150871 GC0XM152023 GC0XM152928 GC0XM154070 GC0XM154158 GC0XM143049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIC2:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization
of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.
Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult
skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CLIC2_HUMAN, O15247
Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2
and inhibits calcium influx

Gene Wiki entry for CLIC2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CLIC2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CLIC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

CLIC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM154505:  view genomic region     (about GC identifiers)

Start:
154,505,500 bp from pter      End:
154,563,986 bp from pter
Size:
58,487 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLIC2_HUMAN, O15247 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 2  
Size: 247 amino acids; 28356 Da
Subunit: Monomer. Interacts with TRAPPC2 and RYR2
Subcellular location: Cytoplasm. Membrane; Single-pass membrane protein (Probable). Note=Exists both as soluble
cytoplasmic protein and as membrane protein with probably a single transmembrane domain
Sequence caution: Sequence=CAA73228.1; Type=Frameshift; Positions=244;
3 PDB 3D structures from and Proteopedia for CLIC2:
2PER (3D)        2R4V (3D)        2R5G (3D)    
Secondary accessions: A8K9S0 O15174 Q5JT80 Q8TCE3

Explore the universe of human proteins at neXtProt for CLIC2: NX_O15247

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15247

  • CLIC2 Protein expression data from MOPED and PaxDb:    About this image 
    CLIC2 Protein Expression
    REFSEQ proteins: NP_001280.3  
    ENSEMBL proteins: 
     ENSP00000358460   ENSP00000318558  

    Human Recombinant Protein Products for CLIC2: 
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    Novus Biologicals CLIC2 Proteins
    Novus Biologicals CLIC2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CLIC2
    Uscn Proteins for CLIC2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0034707chloride channel complex IEA--

    CLIC2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLIC2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O15247

    ProtoNet protein and cluster: O15247

    1 Blocks protein family: IPB002946 Intracellular chloride (Cl-) channel signature

    UniProtKB/Swiss-Prot: CLIC2_HUMAN, O15247
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC2_HUMAN, O15247
    Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
    insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2
    and inhibits calcium influx

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364NOT glutathione transferase activity IDA15147738
    GO:0004602glutathione peroxidase activity IDA15147738
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity TAS9339381
    GO:0005515protein binding IPI12681486
         
    CLIC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CLIC2 

    miRNA
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    OriGene 3'-UTR Clone: CLIC2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CLIC2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC2:
    hsa-miR-140-5p hsa-miR-144 hsa-miR-576-5p hsa-miR-4263 hsa-miR-16-1* hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCLIC2 3' UTR sequence
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters1.00
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC2
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLIC2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CLIC2 (O152473 ENSP000003584604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC2P1P0DI823I2D: score=2 
    TRAPPC2ENSP000003527084STRING: ENSP00000352708
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9339381
    GO:0006821chloride transport ----
    GO:0007165signal transduction TAS16130169
    GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA15916532
    GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC15147738

    CLIC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLIC2

    1 HMDB Compound for CLIC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    4 Novoseek chemical compound relationships for CLIC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 68.5 6 18522493 (2), 15916532 (1), 15147738 (1), 19356589 (1)
    chloride 65.2 12 9339381 (4), 15916532 (1), 19356589 (1), 18007051 (1)
    calcium 16.3 8 15916532 (4), 15147738 (2), 19356589 (1)
    lipid 6.42 1 15916532 (1)

    Search CenterWatch for drugs/clinical trials and news about CLIC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLIC2 gene: 
    NM_001289.4  

    Unigene Cluster for CLIC2:

    Chloride intracellular channel 2
    Hs.655445  [show with all ESTs]
    Unigene Representative Sequence: NM_001289
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369449(uc004fnf.3 uc010nvj.1) ENST00000465553 ENST00000321926
    ENST00000491205

    miRNA
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    hsa-miR-140-5p hsa-miR-144 hsa-miR-576-5p hsa-miR-4263 hsa-miR-16-1* hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCLIC2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC2
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    Additional cDNA sequence: 

    AK292785.1 AY191592.1 BC005367.1 BC022305.1 Y12696.1 

    5 DOTS entries:

    DT.453880  DT.95270543  DT.121303719  DT.95270540  DT.95270541 

    24/118 AceView cDNA sequences (see all 118):

    NM_001289 CD365335 AI457837 AI017399 BU619905 R06352 BX644151 AA843327 
    BU662750 BM955578 AA652698 BG944150 BU658985 AI239716 BX119152 BQ717000 
    AI302953 AI633777 AI768628 BE326646 AI290707 BI755485 BQ894644 AI288487 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAGAGATG
    CLIC2 Expression
    About this image
    See CLIC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC2

    SOURCE GeneReport for Unigene cluster: Hs.655445

    UniProtKB/Swiss-Prot: CLIC2_HUMAN, O15247
    Tissue specificity: Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in
    adult stomach and testis. Expressed in fetal thymus and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CLIC21 chloride intracellular channel 2 73.9(n)
    78.72(a)
      422178  NM_001031114.1  NP_001026285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii clic21 chloride intracellular channel 2 68.79(n)
    72.88(a)
      436834  NM_001002561.1  NP_001002561.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    25(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Chloride intracellular channel exc-4
    25(a)
    20(a)
    many ↔ many
    many ↔ many
    II(14412121-14413389)
    I(14512651-14518707)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATDHAR16
    DHAR26
    (see all 4)
    glutathione S-transferase DHAR2
    (see all 4)
    27(a)
    26(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(6773302-6774528)
    1(28250075-28251350)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    glutathione S-transferase, N-terminal domain conta...
    glutathione S-transferase, N-terminal domain conta...
    20(a)
    19(a)
    many ↔ many
    many ↔ many
    6(6889586-6894645)
    5(876932-880610)


    ENSEMBL Gene Tree for CLIC2 (if available)
    TreeFam Gene Tree for CLIC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC2 gene
    CLIC62  CLIC32  CLIC12  CLIC52  CLIC42  
    6 SIMAP similar genes for CLIC2 using alignment to 3 protein entries:     CLIC2_HUMAN (see all proteins):
    CLIC6    CLIC4    CLIC5    CLIC3    MST130    CLIC1

    CLIC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 NCBI SNPs in CLIC2 are shown (see all 619    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914695981,2
    --154505050(+) TAACTA/GGGTCT 1 -- ds50010--------
    rs1394971631,2
    --154505276(+) TATATA/TCACAT 1 -- ds50010--------
    rs732476781,2
    --154505299(+) TTTAAA/CAATTT 1 -- ds50010--------
    rs1450376181,2
    --154505341(+) CAATCG/TTTTAT 1 -- ds50010--------
    rs1811598111,2
    --154505421(+) TGATAC/TGAAGT 1 -- ds50010--------
    rs1859566811,2
    --154505616(+) TAGGCA/GTAATT 1 -- ut310--------
    rs562239051,2
    C--154505634(+) CCACCG/ACTATA 1 -- ut311Minor allele frequency- A:0.00WA 2
    rs5251611,2
    C,F,H--154505745(+) TGAATA/GCCAAA 1 -- ut3118Minor allele frequency- G:0.35MN NS EA NA WA CSA 2149
    rs1501053071,2
    --154506057(+) TCAAAA/GATTAT 1 -- ut310--------
    rs1455834651,2
    --154506265(+) CTTATA/GCTTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CLIC2 (154505500 - 154563986 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CLIC2
         2 CNVs: 74090 23331
         1 Indel: 97117
    Human Gene Mutation Database (HGMD): CLIC2

    Locus Specific Mutation Databases (LSDB): CLIC2

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLIC2 for disorders           About GeneDecksing

    OMIM gene information: 300138    OMIM disorders: --

    UniProtKB/Swiss-Prot: CLIC2_HUMAN, O15247
  • Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features
  • include atrial fibrillation, cardiomegaly, and congestive heart failure

    3 diseases for CLIC2:    About MalaCards
    cystic lymphangioma    lymphangioma    neuronitis


    Export disorders for CLIC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with CLIC2)
        Utopia: connect your pdf to the dynamic
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    1. Genomic structure of a novel chloride channel gene, CLIC2, in Xq28. (PubMed id 9339381)1, 2, 3, 9 Heiss N.S. and Poustka A. (1997)
    2. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. (PubMed id 15147738)1, 2, 9 Board P.G.... Dulhunty A.F. (2004)
    3. A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. (PubMed id 15916532)1, 2, 9 Dulhunty A.F.... Board P.G. (2005)
    4. The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications. (PubMed id 18186468)1, 2 Mi W.... Su X.D. (2008)
    5. Structure of the Janus protein human CLIC2. (PubMed id 17945253)1, 2 Cromer B.A.... Parker M.W. (2007)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Interaction of Sedlin with chloride intracellular channel proteins. (PubMed id 12681486)1, 2 Fan L.... Zhu X. (2003)
    9. Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2). (PubMed id 18007051)1, 9 Cromer B.A....Parker M.W. (2007)
    10. An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity. (PubMed id 22814392)2 Takano K....Dulhunty A.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1193 HGNC: 2063 AceView: CLIC2 Ensembl:ENSG00000155962 euGenes: HUgn1193
    ECgene: CLIC2 H-InvDB: CLIC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLIC2 gene:
    Search GeneIP for patents involving CLIC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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