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Aliases for CLIC1 Gene

Aliases for CLIC1 Gene

  • Chloride Intracellular Channel 1 2 3
  • Regulatory Nuclear Chloride Ion Channel Protein 3 4
  • Nuclear Chloride Ion Channel 27 3 4
  • Chloride Channel ABP 3 4
  • NCC27 3 4
  • HRNCC 3 4
  • G6 3 4
  • Nuclear Chloride Ion Channel Protein 3
  • RNCC Protein 3
  • P64CLCP 3

External Ids for CLIC1 Gene

Previous GeneCards Identifiers for CLIC1 Gene

  • GC06U990013
  • GC06M031752
  • GC06M031469
  • GC06M031802
  • GC06M031806
  • GC06M031698
  • GC06M031484

Summaries for CLIC1 Gene

Entrez Gene Summary for CLIC1 Gene

  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC1 Gene

CLIC1 (Chloride Intracellular Channel 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC4.

UniProtKB/Swiss-Prot for CLIC1 Gene

  • Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Gene Wiki entry for CLIC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC1 Gene

Genomics for CLIC1 Gene

Regulatory Elements for CLIC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLIC1 Gene

Chromosome:
6
Start:
31,730,581 bp from pter
End:
31,739,763 bp from pter
Size:
9,183 bases
Orientation:
Minus strand

Genomic View for CLIC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for CLIC1 Gene

  • Protein details for CLIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00299-CLIC1_HUMAN
    Recommended name:
    Chloride intracellular channel protein 1
    Protein Accession:
    O00299
    Secondary Accessions:
    • Q15089
    • Q502X1

    Protein attributes for CLIC1 Gene

    Size:
    241 amino acids
    Molecular mass:
    26923 Da
    Quaternary structure:
    • Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.
    Miscellaneous:
    • The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals

    Three dimensional structures from OCA and Proteopedia for CLIC1 Gene

neXtProt entry for CLIC1 Gene

Proteomics data for CLIC1 Gene at MOPED

Post-translational modifications for CLIC1 Gene

  • Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59
  • Ubiquitination at Lys 49, Lys 57, Lys 135, Lys 138, and Lys 183
  • Modification sites at PhosphoSitePlus

Other Protein References for CLIC1 Gene

Antibody Products

No data available for DME Specific Peptides for CLIC1 Gene

Domains & Families for CLIC1 Gene

Gene Families for CLIC1 Gene

Graphical View of Domain Structure for InterPro Entry

O00299

UniProtKB/Swiss-Prot:

CLIC1_HUMAN :
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Belongs to the chloride channel CLIC family.
Domain:
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Contains 1 GST C-terminal domain.
Family:
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC1: view

Function for CLIC1 Gene

Molecular function for CLIC1 Gene

UniProtKB/Swiss-Prot Function:
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Gene Ontology (GO) - Molecular Function for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 NOT glutathione transferase activity IBA --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005254 chloride channel activity IDA 9139710
GO:0005515 protein binding IPI 12163479
genes like me logo Genes that share ontologies with CLIC1: view
genes like me logo Genes that share phenotypes with CLIC1: view

Animal Models for CLIC1 Gene

MGI Knock Outs for CLIC1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CLIC1 Gene

Localization for CLIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC1 Gene

Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIC1 Gene COMPARTMENTS Subcellular localization image for CLIC1 gene
Compartment Confidence
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus TAS 16130169
GO:0005635 nuclear envelope IDA 9139710
GO:0005737 cytoplasm IDA 10793131
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CLIC1: view

Pathways & Interactions for CLIC1 Gene

genes like me logo Genes that share pathways with CLIC1: view

Pathways by source for CLIC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CLIC1 Gene

Gene Ontology (GO) - Biological Process for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 NOT glutathione metabolic process IBA --
GO:0006821 chloride transport IDA 9139710
GO:0007165 signal transduction TAS 16130169
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0045669 positive regulation of osteoblast differentiation IEA --
genes like me logo Genes that share ontologies with CLIC1: view

No data available for SIGNOR curated interactions for CLIC1 Gene

Drugs & Compounds for CLIC1 Gene

(1) Drugs for CLIC1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143

(3) Additional Compounds for CLIC1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
chloride
LIPID
genes like me logo Genes that share compounds with CLIC1: view

Transcripts for CLIC1 Gene

Unigene Clusters for CLIC1 Gene

Chloride intracellular channel 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC1 Gene

No ASD Table

Relevant External Links for CLIC1 Gene

GeneLoc Exon Structure for
CLIC1
ECgene alternative splicing isoforms for
CLIC1

Expression for CLIC1 Gene

mRNA expression in normal human tissues for CLIC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIC1 Gene

This gene is overexpressed in Whole Blood (x10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CLIC1 Gene



SOURCE GeneReport for Unigene cluster for CLIC1 Gene Hs.414565

mRNA Expression by UniProt/SwissProt for CLIC1 Gene

O00299-CLIC1_HUMAN
Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with CLIC1: view

Protein tissue co-expression partners for CLIC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for CLIC1 Gene

Orthologs for CLIC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLIC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CLIC1 35
  • 91.7 (n)
  • 97.51 (a)
CLIC1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLIC1 35
  • 92.39 (n)
  • 98.34 (a)
-- 36
  • 92 (a)
OneToMany
CLIC1 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Clic1 35
  • 90.04 (n)
  • 98.34 (a)
Clic1 16
Clic1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CLIC1 35
  • 99.17 (n)
  • 100 (a)
CLIC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clic1 35
  • 89.9 (n)
  • 98.76 (a)
oppossum
(Monodelphis domestica)
Mammalia CLIC1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLIC1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIC1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clic1 35
  • 69.47 (n)
  • 74.37 (a)
MGC75951 35
African clawed frog
(Xenopus laevis)
Amphibia CLIC1 35
zebrafish
(Danio rerio)
Actinopterygii clic1 35
  • 67.22 (n)
  • 75.93 (a)
clic1 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 20 (a)
ManyToMany
exl-1 36
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DHAR1 35
  • 45.2 (n)
  • 30.89 (a)
rice
(Oryza sativa)
Liliopsida Os05g0116100 35
  • 50.61 (n)
  • 34.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 42 (a)
OneToMany
Species with no ortholog for CLIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLIC1 Gene

ENSEMBL:
Gene Tree for CLIC1 (if available)
TreeFam:
Gene Tree for CLIC1 (if available)

Paralogs for CLIC1 Gene

Paralogs for CLIC1 Gene

(6) SIMAP similar genes for CLIC1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CLIC1 Gene

genes like me logo Genes that share paralogs with CLIC1: view

Variants for CLIC1 Gene

Sequence variations from dbSNP and Humsavar for CLIC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs760150408 -- 31,735,807(+) CCATC(-/CA/CACA/CACACA)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC1 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv884425 CNV Loss 21882294

Variation tolerance for CLIC1 Gene

Residual Variation Intolerance Score: 64.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLIC1 Gene

HapMap Linkage Disequilibrium report
CLIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC1 Gene

Disorders for CLIC1 Gene

Relevant External Links for CLIC1

Genetic Association Database (GAD)
CLIC1
Human Genome Epidemiology (HuGE) Navigator
CLIC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLIC1
genes like me logo Genes that share disorders with CLIC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLIC1 Gene

Publications for CLIC1 Gene

  1. Molecular cloning and expression of a chloride ion channel of cell nuclei. (PMID: 9139710) Valenzuela S.M. … Breit S.N. (J. Biol. Chem. 1997) 2 23 67
  2. Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress. (PMID: 20385134) Averaimo S. … Mazzanti M. (FEBS Lett. 2010) 23 67
  3. Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast. (PMID: 20005186) Gromov P. … Celis J.E. (Mol Oncol 2010) 23 67
  4. Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept. (PMID: 20152045) SuA!rez-FariA+as M. … Lowes M.A. (BMC Dermatol. 2010) 23 67
  5. Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry. (PMID: 19650640) Stoychev S.H. … Dirr H.W. (Biochemistry 2009) 23 67

Products for CLIC1 Gene

Sources for CLIC1 Gene

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