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CLIC1 Gene

protein-coding   GIFtS: 60
GCID: GC06M031698

Chloride Intracellular Channel 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chloride Intracellular Channel 11 2     hRNCC2 3
Chloride Channel ABP2 3     Chloride Intracellular Channel Protein 12
Nuclear Chloride Ion Channel 272 3     Nuclear Chloride Ion Channel Protein2
Regulatory Nuclear Chloride Ion Channel Protein2 3     p64CLCP2
G62 3     RNCC Protein2
NCC272 3     

External Ids:    HGNC: 20621   Entrez Gene: 11922   Ensembl: ENSG000002137197   OMIM: 6028725   UniProtKB: O002993   

Export aliases for CLIC1 gene to outside databases

Previous GC identifers: GC06U990013 GC06M031752 GC06M031469 GC06M031802 GC06M031806 GC06M031484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CLIC1 Gene:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including
stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and
regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes
principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC1 Gene:
CLIC1 (chloride intracellular channel 1) is a protein-coding gene. Diseases associated with CLIC1 include glucosephosphate dehydrogenase deficiency, and gastroenteritis. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of
the cell cycle

Gene Wiki entry for CLIC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CLIC1 gene promoter:
         Sp1   p53   Nkx2-5   Evi-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC1 promoter sequence
   Search Chromatin IP Primers for CLIC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CLIC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

CLIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031698:  view genomic region     (about GC identifiers)

Start:
31,698,358 bp from pter      End:
31,707,540 bp from pter
Size:
9,183 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167247 3,078,041-3,084,028      Chr6-,NT_167249 3,029,175-3,035,164      Chr6-,NT_113891.2 3,207,975-3,213,962     
Chr6-,NT_167248 2,991,988-2,997,979      Chr6-,NT_167246 3,041,248-3,047,235      Chr6-,NT_167245 2,983,927-2,989,912     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 1  
Size: 241 amino acids; 26923 Da
Subunit: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that
leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts
with AKAP9
Miscellaneous: The protein seems to have very low affinity for glutathione, even though glutathione binding was
observed in protein crystals
Selected PDB 3D structures from and Proteopedia for CLIC1 (see all 12):
1K0M (3D)        1K0N (3D)        1K0O (3D)        1RK4 (3D)        3O3T (3D)        3P8W (3D)    
Secondary accessions: Q15089 Q502X1

Explore the universe of human proteins at neXtProt for CLIC1: NX_O00299

Explore proteomics data for CLIC1 at MOPED

Post-translational modifications: 

  • Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an
    intramolecular disulfide bond between Cys-24 and Cys-591
  • Ubiquitination2 at Lys49, Lys57, Lys119, Lys131, Lys135, Lys138, Lys166, Lys183
  • Modification sites at PhosphoSitePlus

  • See CLIC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001274522.1  NP_001274523.1  NP_001279.2  

    ENSEMBL proteins: 
     ENSP00000364940   ENSP00000364934   ENSP00000364935   ENSP00000379229  

    CLIC1 Human Recombinant Protein Products:

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    OriGene MassSpec for CLIC1
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    GenScript Custom Purified and Recombinant Proteins Services for CLIC1
    Novus Biologicals CLIC1 Proteins
    Novus Biologicals CLIC1 Lysate
    Sino Biological Recombinant Protein for CLIC1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CLIC1
    Cloud-Clone Corp. Proteins for CLIC1

    CLIC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CLIC1
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    Abcam antibodies for CLIC1
    Cloud-Clone Corp. Antibodies for CLIC1
    ThermoFisher Antibodies for CLIC1
    LSBio Antibodies in human, mouse, rat for CLIC1

    CLIC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CLIC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLIC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CLIC1
    Cloud-Clone Corp. CLIAs for CLIC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O00299

    ProtoNet protein and cluster: O00299

    2 Blocks protein domains:
    IPB002946 Intracellular chloride (Cl-) channel signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    CLIC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC1_HUMAN, O00299
    Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
    insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of
    the cell cycle

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity IDA9139710
    GO:0005515protein binding IPI12163479
         
    CLIC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLIC1:
     Increased G1 DNA content  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clic1):
     hematopoietic system  homeostasis/metabolism  no phenotypic analysis 

    CLIC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clic1tm1.1Breit for CLIC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CLIC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CLIC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLIC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLIC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CLIC1:
    hsa-mir-25-3p (MIRT050364), hsa-mir-197-3p (MIRT004186), hsa-mir-92a-3p (MIRT049437), hsa-mir-221-3p (MIRT046924), hsa-mir-106b-3p (MIRT038595), hsa-mir-192-5p (MIRT004124), hsa-mir-183-3p (MIRT038667)

    Block miRNA regulation of human, mouse, rat CLIC1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CLIC1:
    hsa-miR-676 hsa-miR-556-3p hsa-miR-548c-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCLIC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CLIC1
    Predesigned siRNA for gene silencing in human, mouse, rat CLIC1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CLIC1

    Clone
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    OriGene clones in human, mouse for CLIC1 (see all 6)
    OriGene ORF clones in mouse, rat for CLIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLIC1 (NM_001288)
    Sino Biological Human cDNA Clone for CLIC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CLIC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CLIC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLIC1_HUMAN, O00299: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell
    membrane; Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane.
    Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane
    protein with probably a single transmembrane domain
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    mitochondrion2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus TAS16130169
    GO:0005635nuclear envelope IDA9139710
    GO:0005737cytoplasm IDA10793131
    GO:0005739mitochondrion IEA--

    CLIC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CLIC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CLIC1
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA



        Pathway & Disease-focused RT2 Profiler PCR Array including CLIC1: 
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CLIC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CLIC1 (O002992, 3 ENSP000003649344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPRNQ4KMQ12, 3MINT-62696 MINT-62598 MINT-62772 I2D: score=2 
    LSM1O151162, 3, ENSP000003105964MINT-62597 MINT-62771 MINT-62695 I2D: score=5 STRING: ENSP00000310596
    AKAP9Q999963, ENSP000003485734I2D: score=2 STRING: ENSP00000348573
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IDA9139710
    GO:0007165signal transduction TAS16130169
    GO:0045669positive regulation of osteoblast differentiation IEA--
    GO:0051881regulation of mitochondrial membrane potential IEA--
    GO:1902476chloride transmembrane transport IDA9139710

    CLIC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CLIC1

    1 HMDB Compound for CLIC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    3 Novoseek inferred chemical compound relationships for CLIC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 83.7 64 11551966 (3), 9139710 (3), 18987185 (3), 9339381 (2) (see all 34)
    cysteine 14.3 1 17945253 (1)
    lipid 0 4 12745921 (1), 18175373 (1), 11551966 (1)



    CLIC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CLIC1 gene (3 alternative transcripts): 
    NM_001287593.1  NM_001287594.1  NM_001288.4  

    Unigene Cluster for CLIC1:

    Chloride intracellular channel 1
    Hs.414565  [show with all ESTs]
    Unigene Representative Sequence: BC064527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375784(uc003nwr.3) ENST00000375779 ENST00000375780 ENST00000395892

    miRNA
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    Block miRNA regulation of human, mouse, rat CLIC1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CLIC1:
    hsa-miR-676 hsa-miR-556-3p hsa-miR-548c-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCLIC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CLIC1
    Predesigned siRNA for gene silencing in human, mouse, rat CLIC1
    Clone
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    OriGene ORF clones in mouse, rat for CLIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CLIC1 (NM_001288)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CLIC1
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    Primer
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    OriGene qPCR primer pairs and template standards for CLIC1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLIC1
      QuantiTect SYBR Green Assays in human, mouse, rat CLIC1
      QuantiFast Probe-based Assays in human, mouse, rat CLIC1

    Additional mRNA sequence: 

    AF034607.1 AF109197.1 AK129773.1 AK223379.1 AK314014.1 BC064527.1 BC095469.1 CR542071.1 
    U93205.1 X87689.1 

    Selected DOTS entries (see all 31):

    DT.100685445  DT.100685450  DT.95232928  DT.95071590  DT.102841787  DT.99986467  DT.100060032  DT.100685437 
    DT.91694767  DT.100685435  DT.92413496  DT.97837675  DT.100685434  DT.95232920  DT.120914096  DT.121408249 
    DT.121408316  DT.121408321  DT.121408373  DT.100032327  DT.100685444  DT.100685451  DT.100685454  DT.121408239 

    Selected AceView cDNA sequences (see all 199):

    CA844285 BU752651 W67261 AA485913 BM670023 W67357 CA941746 BX351450 
    BM141994 BM699366 BE208568 BM691668 BE965260 CA941468 AL542127 AL547266 
    AL526236 BM673312 AL513862 AL545200 CB053951 AA130748 AL527198 R53204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CLIC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGTGGC
    CLIC1 Expression
    About this image


    CLIC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    CLIC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CLIC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414565

    UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
    Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including CLIC1: 
              Hypertension in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CLIC1
    OriGene qSTAR qPCR primer pairs in human, mouse for CLIC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CLIC1
    QuantiTect SYBR Green Assays in human, mouse, rat CLIC1
    QuantiFast Probe-based Assays in human, mouse, rat CLIC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic11 , 5 chloride intracellular channel 11, 5 90.04(n)1
    98.34(a)1
      17 (18.58 cM)5
    1145841  NM_033444.21  NP_254279.11 
     350499665 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC16
    chloride intracellular channel 1
    87(a)
    1 ↔ 1
    GL343570.1(282473-289695)
    African clawed frog
    (Xenopus laevis)
    Amphibia CLIC12 chloride intracellular channel protein 1 73.78(n)    AY277695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027685.12   -- 74.51(n)    CK027685.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    21(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Protein EXC-4 (exc-4) mRNA, complete cds
    25(a)
    20(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465) WBGene00001371
    I(14512663-14518719) WBGene00001365
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DHAR11 DHAR1 45.2(n)
    30.89(a)
      838544  NM_001084095.1  NP_001077564.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01161001 Os05g0116100 50.61(n)
    34.03(a)
      4337622  NM_001061005.1  NP_001054470.1 


    ENSEMBL Gene Tree for CLIC1 (if available)
    TreeFam Gene Tree for CLIC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CLIC1 gene
    CLIC62  CLIC32  CLIC52  CLIC22  CLIC42  
    6 SIMAP similar genes for CLIC1 using alignment to 2 protein entries:     CLIC1_HUMAN (see all proteins):
    CLIC4    MST130    CLIC5    CLIC6    CLIC3    CLIC2

    CLIC1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CLIC1
    PGOHUM00000239944 PGOHUM00000248949 PGOHUM00000237160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CLIC1 (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913909231,2
    --31699271(+) ATGGGA/GTTTCA 1 -- int10--------
    rs1495085101,2
    --31699714(+) CGAGAC/TAGGAA 1 -- int10--------
    rs1827596471,2
    --31700302(+) CTTTTA/CTATGT 1 -- int10--------
    rs1473884671,2
    C--31700609(+) AACTC-/ATTTAT 1 -- int10--------
    rs27361941,2
    C--31700657(-) cctccA/Caaagt 1 -- int10--------
    rs1878797101,2
    --31700665(+) AGGCCA/GAGGCA 1 -- int10--------
    rs1906312191,2
    --31700699(+) TTCAAA/GACCAG 1 -- int10--------
    rs1833464891,2
    --31700768(+) GTGATA/GCACGT 1 -- int10--------
    rs1129201341,2
    C--31700796(+) CAGGAG/CGCTGA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1876441901,2
    --31700884(+) AGAACA/GAGACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLIC1 (31698358 - 31707540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLIC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CLIC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CLIC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602872    OMIM disorders: --

    Selected diseases for CLIC1 (see all 26):    
    About MalaCards
    glucosephosphate dehydrogenase deficiency    gastroenteritis    viral hepatitis    glycogen storage disease
    hemolytic anemia    neutropenia    hyperglycemia    cholera
    colorectal cancer    lung adenocarcinoma    ulcerative colitis    cystic fibrosis
    hepatitis    psoriasis    type 1 diabetes    nasopharyngitis
    systemic lupus erythematosus    lupus erythematosus    hepatitis c    hypertension


    CLIC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CLIC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 13.3 1 18710659 (1)
    tumors 0 3 15041719 (1), 16427064 (1), 18710659 (1)

    Genetic Association Database (GAD): CLIC1
    Human Genome Epidemiology (HuGE) Navigator: CLIC1 (9 documents)

    Export disorders for CLIC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CLIC1 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with CLIC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a chloride ion channel of cell nuclei. (PubMed id 9139710)1, 2, 3, 9 Valenzuela S.M.... Breit S.N. (J. Biol. Chem. 1997)
    2. Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. (PubMed id 11551966)1, 2, 9 Harrop S.J.... Curmi P.M.G. (J. Biol. Chem. 2001)
    3. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. (PubMed id 11195932)1, 2, 9 Valenzuela S.M.... Breit S.N. (J. Physiol. (Lond.) 2000)
    4. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 9 Berryman M. and Bretscher A. (Mol. Biol. Cell 2000)
    5. The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. (PubMed id 14613939)1, 2, 9 Littler D.R.... Curmi P.M.G. (J. Biol. Chem. 2004)
    6. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. (PubMed id 12163479)1, 2, 9 Shanks R.A.... Goldenring J.R. (J. Biol. Chem. 2002)
    7. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 2, 9 Ribas G.... Campbell R.D. (J. Immunol. 1999)
    8. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. (PubMed id 10191309)1, 2, 9 Chuang J.Z.... Sung C.H. (J. Neurosci. 1999)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1192 HGNC: 2062 AceView: CLIC1.1 Ensembl:ENSG00000213719 euGenes: HUgn1192
    ECgene: CLIC1 H-InvDB: CLIC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CLIC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLIC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CLIC1 gene:
    Search GeneIP for patents involving CLIC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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