CLIC1 Gene
protein-coding GIFtS: 56
GCID: GC06M031698
|
|
chloride intracellular channel 1
| |
Aliases
for CLIC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chloride Intracellular Channel 11 2 | | G62 3 | | NCC271 2 3 | | HRNCC1 | | P64CLCP1 | | Chloride Intracellular Channel Protein 12 | | Chloride Channel ABP2 3 | | Nuclear Chloride Ion Channel Protein2 | | Nuclear Chloride Ion Channel 272 3 | | RNCC Protein2 | | Regulatory Nuclear Chloride Ion Channel Protein2 3 | | |
Export aliases for CLIC1 gene to outside databasesPrevious GC identifers: GC06U990013 GC06M031752 GC06M031469 GC06M031802 GC06M031806 GC06M031484 |
Summaries
for CLIC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CLIC1:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilizationof cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleusand exhibits both nuclear and plasma membrane chloride ion channel activity. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membraneinsertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of thecell cycle
Gene Wiki entry for CLIC1
|
Genomic Views
for CLIC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
- NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CLIC1 gene promoter:
Sp1 p53 Nkx2-5 Evi-1 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLIC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3CLIC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031698: view genomic region
(about GC identifiers)
Start:
|
31,698,358 bp from pter |
End:
|
31,707,540 bp from pter |
Size:
|
9,183 bases |
Orientation:
|
minus strand |
6 alternative locations:
| Chr6-,ALT_REF_LOCI_5 31,689,464-31,695,451 | Chr6-,ALT_REF_LOCI_3 31,680,530-31,697,553 | Chr6-,ALT_REF_LOCI_4 31,660,907-31,666,894 | | Chr6-,ALT_REF_LOCI_6 31,688,591-31,730,163 | Chr6-,ALT_REF_LOCI_2 31,685,771-31,730,946 | Chr6-,ALT_REF_LOCI_7 31,618,640-31,624,629 | |
|
Proteins
for CLIC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299 (See
protein sequence)Recommended Name: Chloride intracellular channel protein 1 Size: 241 amino acids; 26923 Da
Subunit: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leadsto the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9
Subcellular location: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell membrane;Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane. Small amount inthe cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein withprobably a single transmembrane domain
Miscellaneous: The protein seems to have very low affinity for glutathione, even though glutathione binding wasobserved in protein crystals
6/11 PDB 3D structures from  and Proteopedia  for CLIC1 (see all 11):1K0M (3D)
1K0N (3D)
1K0O (3D)
1RK4 (3D)
3O3T (3D)
3P8W (3D)
Secondary accessions: Q15089 Q502X1Explore the universe of human proteins at neXtProt for CLIC1: NX_O00299
Post-translational modifications:
Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramoleculardisulfide bond between Cys-24 and Cys-591
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00299
CLIC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001279.2
ENSEMBL proteins: ENSP00000364940 ENSP00000364934 ENSP00000364935 ENSP00000379229
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
CLIC1 for ontologies About GeneDecksing
CLIC1 Antibody Products:
Assay Products for CLIC1: |
Protein
Domains /
Families
for CLIC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLIC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00299ProtoNet protein and cluster: O00299 2 Blocks protein families: IPB002946 Intracellular chloride (Cl-) channel signature IPB004045 Glutathione S-transferase
UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain isinserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain isthought to expose hydrophobic surfaces that trigger membrane insertionSimilarity: Belongs to the chloride channel CLIC familySimilarity: Contains 1 GST C-terminal domain |
Function
for CLIC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membraneinsertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of thecell cycle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CLIC1 (NM_001288) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLIC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CLIC1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CLIC1:
Animal Models:
Mouse knock-out Clic1tm1.1Breit for CLIC1
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Clic1):
CLIC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CLIC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of cAMP-Dependent PKA | | | 2 | Hepatic ABC Transporters | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | |
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/25 Interacting proteins for CLIC1 (O002992, 3 ENSP000003649344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CLIC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CLIC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CLIC1 for compounds About GeneDecksing
 Browse Tocris compounds for CLIC1
1 HMDB Compound for CLIC1 About this table
3 Novoseek chemical compound relationships for CLIC1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CLIC1
|
Transcripts
for CLIC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLIC1 gene: NM_001288.4 Unigene Cluster for CLIC1: Chloride intracellular channel 1 Hs.414565 [show with all ESTs]Unigene Representative Sequence: BC0645274 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375784(uc003nwr.3) ENST00000375779 ENST00000375780 ENST00000395892
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CLIC1 (NM_001288) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLIC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC1 |
Additional cDNA sequence: AF034607.1 AF109197.1 AK129773.1 AK223379.1 AK314014.1 BC064527.1 BC095469.1 CR542071.1 U93205.1 X87689.1 24/31 DOTS entries (see all 31): DT.100685445 DT.100685450 DT.95232928 DT.95071590 DT.102841787 DT.99986467 DT.100060032 DT.100685437 DT.91694767 DT.100685435 DT.92413496 DT.97837675 DT.100685434 DT.95232920 DT.120914096 DT.121408249 DT.121408316 DT.121408321 DT.121408373 DT.100032327 DT.100685444 DT.100685451 DT.100685454 DT.121408239 24/199 AceView cDNA sequences (see all 199): BX351450 BE208568 W67261 BM670023 BM699366 W67357 CA844285 AA485913 CA941746 BU752651 BM141994 AL524906 AL526236 BM673312 CB053951 AL542127 CA941468 AL545200 BE965260 R53204 AL527198 BM691668 AA130748 AL513862
GeneLoc Exon Structure
|
Expression
for CLIC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CLIC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACTGTGGC
About this image
See CLIC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLIC1
SOURCE GeneReport for Unigene cluster: Hs.414565
UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including CLIC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLIC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CLIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1 |
Orthologs
for CLIC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CLIC1 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CLIC16 |
-- |
87(a) |
1 ↔ 1 |
GL343570.1(282473-289695) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CLIC12 |
chloride intracellular channel protein 1 |
73.78(n) |
|
AY277695.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CK027685.12 |
-- |
74.51(n) |
|
CK027685.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Clic6 |
Chloride intracellular channel |
19(a) |
1 → many |
X(13707165-13716357) |
worm
(Caenorhabditis elegans) |
Secernentea |
exl-16exc-46 |
Chloride intracellular channel exc-4 |
22(a)19(a) |
many ↔ manymany ↔ many |
II(14412121-14413389) I(14512651-14518707) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
DHAR11 |
glutathione S-transferase DHAR1 |
45.12(n)
29.8(a) |
|
838544 NM_001084095.1 NP_001077564.1 |
rice
(Oryza sativa) |
Liliopsida |
Os05g01161001 |
hypothetical protein |
50.61(n)
34.03(a) |
|
4337622 NM_001061005.1 NP_001054470.1 |
ENSEMBL Gene Tree for CLIC1 (if available)
TreeFam Gene Tree for CLIC1 (if available) |
Paralogs
for CLIC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CLIC1 gene
- CLIC62 CLIC32 CLIC52 CLIC22 CLIC42
6 SIMAP similar genes for CLIC1 using alignment to 2 protein entries: CLIC1_HUMAN (see all proteins):CLIC4 MST130 CLIC5 CLIC6 CLIC3 CLIC2
CLIC1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CLIC1
PGOHUM00000239944 PGOHUM00000248949 PGOHUM00000237160
|
Genomic Variants
for CLIC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLIC1 (31698358 - 31707540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLIC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIC1 |
|
Disorders
/ Diseases
for CLIC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CLIC1 for disorders About GeneDecksing
OMIM gene information: 602872
OMIM disorders: --
20/23  diseases for CLIC1 (see all 23): About MalaCardsglycogen storage disease systemic lupus erythematosus lupus erythematosus ulcerative colitis
viral hepatitis cystic fibrosis gallbladder carcinoma gastroenteritis
hepatitis c neutropenia colorectal cancer hepatitis b
lung adenocarcinoma hyperglycemia hepatitis fibrosis
hepatocellular carcinoma psoriasis breast carcinoma adenocarcinoma
3 diseases from the University of Copenhagen DISEASES database for CLIC1:Glycogen storage disease Hemolytic anemia Glucosephosphate dehydrogenase deficiency 2 Novoseek disease relationships for CLIC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colorectal cancer |
13.3 |
1 |
18710659 (1) |
| tumors |
0 |
3 |
15041719 (1), 16427064 (1), 18710659 (1) |
Human Genome Epidemiology (HuGE) Navigator: CLIC1 (9 documents)
Export disorders for CLIC1 gene to outside databases
|
Publications
for CLIC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLIC1 gene, integrated from 9 sources (see all 88):
(articles sorted by number of sources associating them with CLIC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of a chloride ion channel of cell nuclei. (PubMed id 9139710)1, 2, 3, 9 Valenzuela S.M.... Breit S.N. (1997)
- Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. (PubMed id 11551966)1, 2, 9 Harrop S.J.... Curmi P.M.G. (2001)
- The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. (PubMed id 11195932)1, 2, 9 Valenzuela S.M....Breit S.N. (2000)
- Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 9 Berryman M. and Bretscher A. (2000)
- The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. (PubMed id 14613939)1, 2, 9 Littler D.R....Curmi P.M. (2004)
- AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. (PubMed id 12163479)1, 2, 9 Shanks R.A.... Goldenring J.R. (2002)
- Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 2, 9 Ribas G.... Campbell R.D. (1999)
- A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. (PubMed id 10191309)1, 2, 9 Chuang J.Z.... Sung C.H. (1999)
- Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH. (PubMed id 18850721)1, 2 Fanucchi S.... Dirr H.W. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CLIC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLIC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLIC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLIC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLIC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLIC1 gene:
Search GeneIP for patents involving CLIC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLIC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLIC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLIC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLIC1 | | | OriGene Protein Over-expression Lysate for CLIC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLIC1 | | OriGene 3'-UTR Clone for CLIC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLIC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLIC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLIC1 | | OriGene Custom Protein Services for CLIC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLIC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLIC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLIC1 |
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| | | | Search Tocris compounds for CLIC1 |
| |  |  |  |  | | | | | | Recombinant Protein for CLIC1 |
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 | | | CLIC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1 |
|  |  |  | | | | ThermoFisher Antibodies for CLIC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLIC1 |
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