Aliases for CLIC1 Gene
External Ids for CLIC1 Gene
Previous GeneCards Identifiers for CLIC1 Gene
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLIC1 Gene
CLIC1 (Chloride Intracellular Channel 1) is a Protein Coding gene. Diseases associated with CLIC1 include Blackwater Fever and Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC4.
UniProtKB/Swiss-Prot for CLIC1 Gene
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.