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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLIC1 Gene

protein-coding   GIFtS: 60
GCID: GC06M031698

Chloride Intracellular Channel 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chloride Intracellular Channel 11 2     hRNCC2 3
Chloride Channel ABP2 3     Chloride Intracellular Channel Protein 12
Nuclear Chloride Ion Channel 272 3     Nuclear Chloride Ion Channel Protein2
Regulatory Nuclear Chloride Ion Channel Protein2 3     p64CLCP2
G62 3     RNCC Protein2
NCC272 3     

External Ids:    HGNC: 20621   Entrez Gene: 11922   Ensembl: ENSG000002137197   OMIM: 6028725   UniProtKB: O002993   

Export aliases for CLIC1 gene to outside databases

Previous GC identifers: GC06U990013 GC06M031752 GC06M031469 GC06M031802 GC06M031806 GC06M031484


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLIC1 Gene:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including
stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and
regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes
principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CLIC1 Gene: 
CLIC1 (chloride intracellular channel 1) is a protein-coding gene. Diseases associated with CLIC1 include glucosephosphate dehydrogenase deficiency, and gastroenteritis, and among its related super-pathways are Activation of cAMP-Dependent PKA and MODY (Maturity-Onset Diabetes of Young). GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC6.

UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of
the cell cycle

Gene Wiki entry for CLIC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  
NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLIC1 gene promoter:
         Sp1   p53   Nkx2-5   Evi-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLIC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLIC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLIC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

CLIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLIC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031698:  view genomic region     (about GC identifiers)

Start:
31,698,358 bp from pter      End:
31,707,540 bp from pter
Size:
9,183 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167246 3,041,248-3,047,235      Chr6-,NT_113891.2 3,207,975-3,213,962      Chr6-,NT_167248 2,991,988-2,997,979     
Chr6-,NT_167245 2,983,927-2,989,912      Chr6-,NT_167249 3,029,175-3,035,164      Chr6-,NT_167247 3,078,041-3,084,028     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299 (See protein sequence)
Recommended Name: Chloride intracellular channel protein 1  
Size: 241 amino acids; 26923 Da
Subunit: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that
leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts
with AKAP9
Subcellular location: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell
membrane; Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane.
Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane
protein with probably a single transmembrane domain
Miscellaneous: The protein seems to have very low affinity for glutathione, even though glutathione binding was
observed in protein crystals
6/12 PDB 3D structures from and Proteopedia for CLIC1 (see all 12):
1K0M (3D)        1K0N (3D)        1K0O (3D)        1RK4 (3D)        3O3T (3D)        3P8W (3D)    
Secondary accessions: Q15089 Q502X1

Explore the universe of human proteins at neXtProt for CLIC1: NX_O00299

Explore proteomics data for CLIC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an
    intramolecular disulfide bond between Cys-24 and Cys-59
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00299

  • CLIC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLIC1 Protein Expression
    REFSEQ proteins: NP_001279.2  
    ENSEMBL proteins: 
     ENSP00000364940   ENSP00000364934   ENSP00000364935   ENSP00000379229  

    Human Recombinant Protein Products for CLIC1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CLIC1
    Cloud-Clone Corp. Proteins for CLIC1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005635nuclear envelope IDA9139710
    GO:0005737cytoplasm IDA10793131
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane IEA--

    CLIC1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CLIC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLIC: Ion channels / Chloride channels : Intracellular

    4 InterPro protein domains:
     IPR002946 Int_Cl_channel
     IPR012336 Thioredoxin-like_fold
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O00299

    ProtoNet protein and cluster: O00299

    2 Blocks protein domains:
    IPB002946 Intracellular chloride (Cl-) channel signature
    IPB004045 Glutathione S-transferase


    UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
    Domain: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is
    inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is
    thought to expose hydrophobic surfaces that trigger membrane insertion
    Similarity: Belongs to the chloride channel CLIC family
    Similarity: Contains 1 GST C-terminal domain


    CLIC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLIC1_HUMAN, O00299
    Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane
    insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of
    the cell cycle

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005247voltage-gated chloride channel activity IEA--
    GO:0005254chloride channel activity IDA9139710
    GO:0005515protein binding IPI12163479
         
    CLIC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CLIC1:
     Increased G1 DNA content  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clic1):
     hematopoietic system  homeostasis/metabolism  no phenotypic analysis 

    CLIC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Clic1tm1.1Breit for CLIC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CLIC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CLIC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CLIC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CLIC1 

    miRNA
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    miRTarBase miRNAs that target CLIC1:
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CLIC1:
    hsa-miR-676 hsa-miR-556-3p hsa-miR-548c-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidCLIC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CLIC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CLIC1
        Cholera Infection
    Hepatic ABC Transporters
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CLIC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/25 Interacting proteins for CLIC1 (O002992, 3 ENSP000003649344) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPRNQ4KMQ12, 3MINT-62696 MINT-62598 MINT-62772 I2D: score=2 
    LSM1O151162, 3, ENSP000003105964MINT-62597 MINT-62771 MINT-62695 I2D: score=5 STRING: ENSP00000310596
    AKAP9Q999963, ENSP000003485734I2D: score=2 STRING: ENSP00000348573
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IDA9139710
    GO:0007165signal transduction TAS16130169
    GO:0045669positive regulation of osteoblast differentiation IEA--
    GO:0051881regulation of mitochondrial membrane potential IEA--

    CLIC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CLIC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CLIC1

    1 HMDB Compound for CLIC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    3 Novoseek inferred chemical compound relationships for CLIC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 83.7 64 11551966 (3), 9139710 (3), 18987185 (3), 9339381 (2) (see all 34)
    cysteine 14.3 1 17945253 (1)
    lipid 0 4 12745921 (1), 18175373 (1), 11551966 (1)

    Search CenterWatch for drugs/clinical trials and news about CLIC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CLIC1 gene: 
    NM_001288.4  

    Unigene Cluster for CLIC1:

    Chloride intracellular channel 1
    Hs.414565  [show with all ESTs]
    Unigene Representative Sequence: BC064527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375784(uc003nwr.3) ENST00000375779 ENST00000375780 ENST00000395892

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-676 hsa-miR-556-3p hsa-miR-548c-3p hsa-miR-3657
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    Additional mRNA sequence: 

    AF034607.1 AF109197.1 AK129773.1 AK223379.1 AK314014.1 BC064527.1 BC095469.1 CR542071.1 
    U93205.1 X87689.1 

    24/31 DOTS entries (see all 31):

    DT.100685445  DT.100685450  DT.95232928  DT.95071590  DT.102841787  DT.99986467  DT.100060032  DT.100685437 
    DT.91694767  DT.100685435  DT.92413496  DT.97837675  DT.100685434  DT.95232920  DT.120914096  DT.121408249 
    DT.121408316  DT.121408321  DT.121408373  DT.100032327  DT.100685444  DT.100685451  DT.100685454  DT.121408239 

    24/199 AceView cDNA sequences (see all 199):

    CA844285 BU752651 W67261 AA485913 BM670023 W67357 CA941746 BX351450 
    BM141994 BM699366 BE208568 AL513862 AL545200 BM691668 BE965260 CA941468 
    AL542127 AL547266 AL526236 BM673312 CB053951 AA130748 AL527198 R53204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLIC1 expression in normal human tissues (normalized intensities)      CLIC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGTGGC
    CLIC1 Expression
    About this image


    CLIC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Oral Cavity (Gastrointestinal Tract)
             salivary gland   

    See CLIC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLIC1

    SOURCE GeneReport for Unigene cluster: Hs.414565

    UniProtKB/Swiss-Prot: CLIC1_HUMAN, O00299
    Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including CLIC1: 
              Hypertension in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLIC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CLIC1 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clic11 , 5 chloride intracellular channel 11, 5 90.04(n)1
    98.34(a)1
      17 (18.58 cM)5
    1145841  NM_033444.21  NP_254279.11 
     350499665 
    lizard
    (Anolis carolinensis)
    Reptilia CLIC16
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343570.1(282473-289695)
    African clawed frog
    (Xenopus laevis)
    Amphibia CLIC12 chloride intracellular channel protein 1 73.78(n)    AY277695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027685.12   -- 74.51(n)    CK027685.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clic6
    Chloride intracellular channel
    21(a)
    1 → many
    X(13707165-13716357)
    worm
    (Caenorhabditis elegans)
    Secernentea exl-16
    exc-46
    Chloride intracellular channel exc-4
    27(a)
    18(a)
    many ↔ many
    many ↔ many
    II(14412197-14413465)
    I(14512663-14518719)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DHAR11 glutathione S-transferase DHAR1 45.12(n)
    29.8(a)
      838544  NM_001084095.1  NP_001077564.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01161001 hypothetical protein 50.61(n)
    34.03(a)
      4337622  NM_001061005.1  NP_001054470.1 


    ENSEMBL Gene Tree for CLIC1 (if available)
    TreeFam Gene Tree for CLIC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CLIC1 gene
    CLIC62  CLIC32  CLIC52  CLIC22  CLIC42  
    6 SIMAP similar genes for CLIC1 using alignment to 2 protein entries:     CLIC1_HUMAN (see all proteins):
    CLIC4    MST130    CLIC5    CLIC6    CLIC3    CLIC2

    CLIC1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CLIC1
    PGOHUM00000239944 PGOHUM00000248949 PGOHUM00000237160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/107 SNPs in CLIC1 are shown (see all 107)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913909231,2
    --31699271(+) ATGGGA/GTTTCA 1 -- int10--------
    rs1495085101,2
    --31699714(+) CGAGAC/TAGGAA 1 -- int10--------
    rs1827596471,2
    --31700302(+) CTTTTA/CTATGT 1 -- int10--------
    rs1473884671,2
    C--31700609(+) AACTC-/ATTTAT 1 -- int10--------
    rs27361941,2
    C--31700657(-) cctccA/Caaagt 1 -- int10--------
    rs1878797101,2
    --31700665(+) AGGCCA/GAGGCA 1 -- int10--------
    rs1906312191,2
    --31700699(+) TTCAAA/GACCAG 1 -- int10--------
    rs1833464891,2
    --31700768(+) GTGATA/GCACGT 1 -- int10--------
    rs1129201341,2
    C--31700796(+) CAGGAG/CGCTGA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1876441901,2
    --31700884(+) AGAACA/GAGACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CLIC1 (31698358 - 31707540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CLIC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602872    OMIM disorders: --

    20/28 diseases for CLIC1 (see all 28):    About MalaCards
    glucosephosphate dehydrogenase deficiency    gastroenteritis    viral hepatitis    glycogen storage disease
    hemolytic anemia    neutropenia    lung adenocarcinoma    hyperglycemia
    colorectal cancer    ulcerative colitis    cystic fibrosis    cholera
    psoriasis    hepatitis    type 1 diabetes    hepatitis c
    systemic lupus erythematosus    lupus erythematosus    hepatitis b    anemia


    CLIC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CLIC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 13.3 1 18710659 (1)
    tumors 0 3 15041719 (1), 16427064 (1), 18710659 (1)

    Genetic Association Database (GAD): CLIC1
    Human Genome Epidemiology (HuGE) Navigator: CLIC1 (9 documents)

    Export disorders for CLIC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLIC1 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with CLIC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a chloride ion channel of cell nuclei. (PubMed id 9139710)1, 2, 3, 9 Valenzuela S.M.... Breit S.N. (1997)
    2. Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. (PubMed id 11551966)1, 2, 9 Harrop S.J.... Curmi P.M.G. (2001)
    3. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. (PubMed id 11195932)1, 2, 9 Valenzuela S.M....Breit S.N. (2000)
    4. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PubMed id 10793131)1, 2, 9 Berryman M. and Bretscher A. (2000)
    5. The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. (PubMed id 14613939)1, 2, 9 Littler D.R....Curmi P.M. (2004)
    6. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. (PubMed id 12163479)1, 2, 9 Shanks R.A.... Goldenring J.R. (2002)
    7. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 2, 9 Ribas G.... Campbell R.D. (1999)
    8. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. (PubMed id 10191309)1, 2, 9 Chuang J.Z.... Sung C.H. (1999)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1192 HGNC: 2062 AceView: CLIC1.1 Ensembl:ENSG00000213719 euGenes: HUgn1192
    ECgene: CLIC1 H-InvDB: CLIC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLIC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CLIC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLIC1 gene:
    Search GeneIP for patents involving CLIC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Regulatory tfbs in CLIC1 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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