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Aliases for CLIC1 Gene

Aliases for CLIC1 Gene

  • Chloride Intracellular Channel 1 2 3
  • Regulatory Nuclear Chloride Ion Channel Protein 3 4
  • Nuclear Chloride Ion Channel 27 3 4
  • Chloride Channel ABP 3 4
  • NCC27 3 4
  • HRNCC 3 4
  • G6 3 4
  • Chloride Intracellular Channel Protein 1 3
  • Nuclear Chloride Ion Channel Protein 3
  • RNCC Protein 3
  • P64CLCP 3

External Ids for CLIC1 Gene

Previous GeneCards Identifiers for CLIC1 Gene

  • GC06U990013
  • GC06M031752
  • GC06M031469
  • GC06M031802
  • GC06M031806
  • GC06M031698
  • GC06M031484

Summaries for CLIC1 Gene

Entrez Gene Summary for CLIC1 Gene

  • Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLIC1 Gene

CLIC1 (Chloride Intracellular Channel 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include chloride channel activity and voltage-gated chloride channel activity. An important paralog of this gene is CLIC4.

UniProtKB/Swiss-Prot for CLIC1 Gene

  • Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Gene Wiki entry for CLIC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC1 Gene

Genomics for CLIC1 Gene

Regulatory Elements for CLIC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CLIC1 Gene

31,730,581 bp from pter
31,739,763 bp from pter
9,183 bases
Minus strand

Genomic View for CLIC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for CLIC1 Gene

  • Protein details for CLIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride intracellular channel protein 1
    Protein Accession:
    Secondary Accessions:
    • Q15089
    • Q502X1

    Protein attributes for CLIC1 Gene

    241 amino acids
    Molecular mass:
    26923 Da
    Quaternary structure:
    • Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.
    • The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals

    Three dimensional structures from OCA and Proteopedia for CLIC1 Gene

neXtProt entry for CLIC1 Gene

Proteomics data for CLIC1 Gene at MOPED

Post-translational modifications for CLIC1 Gene

  • Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59
  • Ubiquitination at Lys49, Lys57, Lys119, Lys131, Lys135, Lys138, Lys166, and Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for CLIC1 Gene

Antibody Products

No data available for DME Specific Peptides for CLIC1 Gene

Domains for CLIC1 Gene

Gene Families for CLIC1 Gene

  • CLIC :Ion channels / Chloride channels : Intracellular

Graphical View of Domain Structure for InterPro Entry



  • O00299
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Contains 1 GST C-terminal domain.
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC1: view

Function for CLIC1 Gene

Molecular function for CLIC1 Gene

UniProtKB/Swiss-Prot Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Gene Ontology (GO) - Molecular Function for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005247 voltage-gated chloride channel activity --
GO:0005254 chloride channel activity IDA 9139710
GO:0005515 protein binding IPI 12163479
genes like me logo Genes that share ontologies with CLIC1: view

Phenotypes for CLIC1 Gene

genes like me logo Genes that share phenotypes with CLIC1: view

Animal Models for CLIC1 Gene

MGI Knock Outs for CLIC1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLIC1 Gene

Localization for CLIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC1 Gene

Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Subcellular locations from

Jensen Localization Image for CLIC1 Gene COMPARTMENTS Subcellular localization image for CLIC1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus TAS 16130169
GO:0005635 nuclear envelope IDA 9139710
GO:0005737 cytoplasm IDA 10793131
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CLIC1: view

Pathways for CLIC1 Gene

genes like me logo Genes that share pathways with CLIC1: view

Pathways by source for CLIC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CLIC1 Gene

Gene Ontology (GO) - Biological Process for CLIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 9139710
GO:0007165 signal transduction TAS 16130169
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0044070 regulation of anion transport --
GO:0045669 positive regulation of osteoblast differentiation IEA --
genes like me logo Genes that share ontologies with CLIC1: view

Compounds for CLIC1 Gene

(1) HMDB Compounds for CLIC1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2

(3) Novoseek inferred chemical compound relationships for CLIC1 Gene

Compound -log(P) Hits PubMed IDs
chloride 83.7 44
cysteine 14.3 1
lipid 0 3
genes like me logo Genes that share compounds with CLIC1: view

Transcripts for CLIC1 Gene

Unigene Clusters for CLIC1 Gene

Chloride intracellular channel 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC1 Gene

No ASD Table

Relevant External Links for CLIC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLIC1 Gene

mRNA expression in normal human tissues for CLIC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIC1 Gene

This gene is overexpressed in Whole Blood (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CLIC1 Gene

SOURCE GeneReport for Unigene cluster for CLIC1 Gene Hs.414565

mRNA Expression by UniProt/SwissProt for CLIC1 Gene

Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas.
genes like me logo Genes that share expressions with CLIC1: view

In Situ Assay Products

Orthologs for CLIC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLIC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLIC1 35
  • 99.17 (n)
  • 100 (a)
CLIC1 36
  • 100 (a)
(Bos Taurus)
Mammalia CLIC1 35
  • 91.7 (n)
  • 97.51 (a)
CLIC1 36
  • 98 (a)
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
CLIC1 35
  • 92.39 (n)
  • 98.34 (a)
CLIC1 36
  • 94 (a)
(Mus musculus)
Mammalia Clic1 35
  • 90.04 (n)
  • 98.34 (a)
Clic1 16
Clic1 36
  • 98 (a)
(Monodelphis domestica)
Mammalia CLIC1 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CLIC1 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Clic1 35
  • 89.9 (n)
  • 98.76 (a)
(Anolis carolinensis)
Reptilia CLIC1 36
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia CLIC1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia clic1 35
  • 69.47 (n)
  • 74.37 (a)
MGC75951 35
(Danio rerio)
Actinopterygii clic1 35
  • 67.22 (n)
  • 75.93 (a)
clic1 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 20 (a)
exl-1 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DHAR1 35
  • 45.2 (n)
  • 30.89 (a)
(Oryza sativa)
Liliopsida Os05g0116100 35
  • 50.61 (n)
  • 34.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 42 (a)
Species with no ortholog for CLIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLIC1 Gene

Gene Tree for CLIC1 (if available)
Gene Tree for CLIC1 (if available)

Paralogs for CLIC1 Gene

Paralogs for CLIC1 Gene

Selected SIMAP similar genes for CLIC1 Gene using alignment to 2 proteins: Pseudogenes for CLIC1 Gene

genes like me logo Genes that share paralogs with CLIC1: view

Variants for CLIC1 Gene

Sequence variations from dbSNP and Humsavar for CLIC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs377749 -- 31,737,406(-) gctct(G/T)attgc upstream-variant-2KB
rs378538 -- 31,737,157(-) CGTGA(A/G)CCACC utr-variant-5-prime, upstream-variant-2KB
rs400502 -- 31,734,981(-) CTGTG(A/G)GAGGA intron-variant
rs400547 -- 31,734,933(-) TGGCA(A/G)CAGGT intron-variant
rs1049227 -- 31,733,924(+) GGGGG(C/G)AGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CLIC1 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv884425 CNV Loss 21882294

Relevant External Links for CLIC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC1 Gene

Disorders for CLIC1 Gene

(2) Novoseek inferred disease relationships for CLIC1 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 13.3 1
tumors 0 3

Relevant External Links for CLIC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CLIC1: view

No data available for UniProtKB/Swiss-Prot for CLIC1 Gene

Publications for CLIC1 Gene

  1. Molecular cloning and expression of a chloride ion channel of cell nuclei. (PMID: 9139710) Valenzuela S.M. … Breit S.N. (J. Biol. Chem. 1997) 2 3 4 23
  2. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons. (PMID: 10191309) Chuang J.Z. … Sung C.H. (J. Neurosci. 1999) 3 4 23
  3. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PMID: 10384126) Ribas G. … Campbell R.D. (J. Immunol. 1999) 3 4 23
  4. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (PMID: 10793131) Berryman M. … Bretscher A. (Mol. Biol. Cell 2000) 3 4 23
  5. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. (PMID: 11195932) Valenzuela S.M. … Breit S.N. (J. Physiol. (Lond.) 2000) 3 4 23

Products for CLIC1 Gene

Sources for CLIC1 Gene

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