CLHC1 Gene
protein-coding GIFtS: 36
GCID: GC02M055400
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|
clathrin heavy chain linker domain containing 1(Previous name: chromosome 2 open reading frame 63 )
(Previous symbol: C2orf63)
| |
Aliases
for CLHC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Clathrin Heavy Chain Linker Domain Containing 11 2 | | C2orf631 2 3 | | FLJ314381 | | Chromosome 2 Open Reading Frame 631 | | Clathrin Heavy Chain Linker Domain-Containing Protein 12 |
Export aliases for CLHC1 gene to outside databases |
Summaries
for CLHC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CLHC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CLHC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLHC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLHC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p16.1 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p16.1CLHC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M055400: view genomic region
(about GC identifiers)
Start:
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55,399,683 bp from pter |
End:
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55,459,699 bp from pter |
Size:
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60,017 bases |
Orientation:
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minus strand |
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Proteins
for CLHC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLHC1_HUMAN, Q8NHS4 (See
protein sequence)Recommended Name: Clathrin heavy chain linker domain-containing protein 1 Size: 586 amino acids; 67250 Da
Secondary accessions: B2RDV1 Q53R93 Q8N403Alternative splicing: 2 isoforms: Q8NHS4-1 Q8NHS4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CLHC1: NX_Q8NHS4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NHS4
CLHC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129070.1 NP_689598.2
ENSEMBL proteins: ENSP00000401526 ENSP00000385778 ENSP00000384869 ENSP00000385512 ENSP00000399821 ENSP00000407575 ENSP00000385598 ENSP00000400116 ENSP00000384810
Human Recombinant Protein Products:
CLHC1 Antibody Products:
Assay Products for CLHC1: |
Protein
Domains /
Families
for CLHC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLHC1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NHS4ProtoNet protein and cluster: Q8NHS4 |
Function
for CLHC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CLHC1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLHC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLHC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLHC1 |
|
Pathways & Interactions
for CLHC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLHC1
1 Interacting protein for CLHC1 (Q8NHS43) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CLHC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CLHC1
Search CenterWatch for drugs/clinical trials and news about CLHC1
|
Transcripts
for CLHC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CLHC1 gene (2 alternative transcripts): NM_001135598.1 NM_152385.2 Unigene Cluster for CLHC1: Clathrin heavy chain linker domain containing 1 Hs.347014 [show with all ESTs]Unigene Representative Sequence: NM_15238514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428621 ENST00000494539 ENST00000407122 ENST00000401408(uc002ryi.2)
ENST00000406076(uc002ryj.2) ENST00000411884 ENST00000487320 ENST00000466020
ENST00000451916 ENST00000464243 ENST00000463300 ENST00000403506 ENST00000425841
ENST00000406437(uc002ryh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CLHC1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CLHC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLHC1 |
Additional cDNA sequence: AK056000.1 AK315683.1 BC029502.1 BC036908.1 16 DOTS entries: DT.95313101 DT.110370 DT.97792960 DT.95359133 DT.95369058 DT.120997599 DT.120997660 DT.97805300 DT.305521 DT.95092055 DT.95364079 DT.102843647 DT.120997602 DT.120997636 DT.95174733 DT.91927036 24/47 AceView cDNA sequences (see all 47): BU541994 BM352754 AA553339 CA777564 AW296999 BX111064 AA905470 AA748422 CK905859 BP370196 AW119054 AK056000 BC029502 AW516278 BQ130526 BI460750 AA782992 BM353033 BF436264 BC036908 AW194706 BX645508 BI827670 BX281970
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CLHC1 (see all 18) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | · | 19d |
|---|
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| SP1: | - | | - | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CLHC1
|
Expression
for CLHC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See CLHC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CLHC1
SOURCE GeneReport for Unigene cluster: Hs.347014
SABiosciences Custom PCR Arrays for CLHC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLHC1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CLHC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLHC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLHC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLHC1 |
Orthologs
for CLHC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CLHC1 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for CLHC1 (if available)
TreeFam Gene Tree for CLHC1 (if available) |
Paralogs
for CLHC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CLHC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CLHC1 (55399683 - 55459699 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLHC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLHC1 |
|
Disorders
/ Diseases
for CLHC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CLHC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CLHC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CLHC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for CLHC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CLHC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CLHC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CLHC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CLHC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CLHC1 gene:
Search GeneIP for patents involving CLHC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CLHC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CLHC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CLHC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CLHC1 | | | OriGene Protein Over-expression Lysate for CLHC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CLHC1 | | OriGene 3'-UTR Clone for CLHC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CLHC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CLHC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CLHC1 | | OriGene Custom Protein Services for CLHC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CLHC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CLHC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLHC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CLHC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLHC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CLHC1 |
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 |  |  |  | |
| | | | Search Tocris compounds for CLHC1 |
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 | | | CLHC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLHC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CLHC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CLHC1 |
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