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Aliases for CLGN Gene

Aliases for CLGN Gene

  • Calmegin 2 3 5

External Ids for CLGN Gene

Previous GeneCards Identifiers for CLGN Gene

  • GC04M142172
  • GC04M141626
  • GC04M141775
  • GC04M141887
  • GC04M141667
  • GC04M141529
  • GC04M141309
  • GC04M137040

Summaries for CLGN Gene

Entrez Gene Summary for CLGN Gene

  • Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLGN Gene

CLGN (Calmegin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein binding involved in protein folding. An important paralog of this gene is CALR.

UniProtKB/Swiss-Prot for CLGN Gene

  • Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Wiki entry for CLGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLGN Gene

Genomics for CLGN Gene

Regulatory Elements for CLGN Gene

Promoters for CLGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLGN on UCSC Golden Path with GeneCards custom track

Genomic Location for CLGN Gene

Chromosome:
4
Start:
140,388,453 bp from pter
End:
140,427,968 bp from pter
Size:
39,516 bases
Orientation:
Minus strand

Genomic View for CLGN Gene

Genes around CLGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLGN Gene

Proteins for CLGN Gene

  • Protein details for CLGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14967-CLGN_HUMAN
    Recommended name:
    Calmegin
    Protein Accession:
    O14967
    Secondary Accessions:
    • B3KS90
    • B4DXV8
    • D3DNY8

    Protein attributes for CLGN Gene

    Size:
    610 amino acids
    Molecular mass:
    70039 Da
    Quaternary structure:
    • Interacts with PPIB. Interacts with ADAM2 (By similarity). Interacts with PDILT.

    Alternative splice isoforms for CLGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLGN Gene

Proteomics data for CLGN Gene at MOPED

Post-translational modifications for CLGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLGN Gene

Antibody Products

No data available for DME Specific Peptides for CLGN Gene

Domains & Families for CLGN Gene

Protein Domains for CLGN Gene

Suggested Antigen Peptide Sequences for CLGN Gene

Graphical View of Domain Structure for InterPro Entry

O14967

UniProtKB/Swiss-Prot:

CLGN_HUMAN :
  • Belongs to the calreticulin family.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CLGN: view

No data available for Gene Families for CLGN Gene

Function for CLGN Gene

Molecular function for CLGN Gene

UniProtKB/Swiss-Prot Function:
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Ontology (GO) - Molecular Function for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044183 protein binding involved in protein folding IEA --
genes like me logo Genes that share ontologies with CLGN: view
genes like me logo Genes that share phenotypes with CLGN: view

Animal Models for CLGN Gene

MGI Knock Outs for CLGN:

Animal Model Products

miRNA for CLGN Gene

miRTarBase miRNAs that target CLGN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLGN Gene

Localization for CLGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLGN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLGN Gene COMPARTMENTS Subcellular localization image for CLGN gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CLGN Gene

Pathways & Interactions for CLGN Gene

SuperPathways for CLGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLGN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLGN Gene

Drugs & Compounds for CLGN Gene

(1) Drugs for CLGN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLGN: view

Transcripts for CLGN Gene

Unigene Clusters for CLGN Gene

Calmegin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLGN Gene

No ASD Table

Relevant External Links for CLGN Gene

GeneLoc Exon Structure for
CLGN
ECgene alternative splicing isoforms for
CLGN

Expression for CLGN Gene

mRNA expression in normal human tissues for CLGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLGN Gene

This gene is overexpressed in Heart - Left Ventricle (x11.6), Testis (x11.1), and Heart - Atrial Appendage (x8.4).

Protein differential expression in normal tissues from HIPED for CLGN Gene

This gene is overexpressed in Ovary (54.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLGN Gene



SOURCE GeneReport for Unigene cluster for CLGN Gene Hs.86368

mRNA Expression by UniProt/SwissProt for CLGN Gene

O14967-CLGN_HUMAN
Tissue specificity: Detected in testis (at protein level). Detected in testis.
genes like me logo Genes that share expression patterns with CLGN: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CLGN Gene

Orthologs for CLGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLGN 35
  • 99.65 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia CLGN 35
  • 90.7 (n)
  • 87.13 (a)
CLGN 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLGN 36
  • 88 (a)
OneToOne
CLGN 35
  • 92.08 (n)
  • 89.84 (a)
mouse
(Mus musculus)
Mammalia Clgn 36
  • 80 (a)
OneToOne
Clgn 16
Clgn 35
  • 79.37 (n)
  • 77.5 (a)
oppossum
(Monodelphis domestica)
Mammalia CLGN 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLGN 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clgn 35
  • 78.16 (n)
  • 77.83 (a)
chicken
(Gallus gallus)
Aves CLGN 35
  • 72.06 (n)
  • 66.83 (a)
CLGN 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLGN 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clgn 35
  • 67.01 (n)
  • 60.55 (a)
zebrafish
(Danio rerio)
Actinopterygii clgn 36
  • 59 (a)
OneToOne
clgn 35
  • 65.13 (n)
  • 62.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1924 37
  • 47 (a)
CG9906 37
  • 45 (a)
Cnx99A 37
  • 58 (a)
CG1924 36
  • 41 (a)
ManyToMany
Cnx14D 36
  • 43 (a)
ManyToMany
Cnx99A 36
  • 42 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cnx-1 37
  • 43 (a)
cnx-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 36
  • 28 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09265 35
  • 49.84 (n)
  • 46.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnx1 35
  • 57.13 (n)
  • 47.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CLGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLGN Gene

ENSEMBL:
Gene Tree for CLGN (if available)
TreeFam:
Gene Tree for CLGN (if available)

Paralogs for CLGN Gene

Paralogs for CLGN Gene

(2) SIMAP similar genes for CLGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLGN: view

Variants for CLGN Gene

Sequence variations from dbSNP and Humsavar for CLGN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2567241 - 140,402,008(+) GTCTG(A/C)TAGGA reference, missense
rs2175563 - 140,398,867(+) TTTGA(C/T)GGCAG reference, missense
rs12513290 - 140,395,914(+) AATCC(A/G)ACATG reference, missense
rs358302 -- 140,405,333(+) gcgcc(C/T)gccac intron-variant
rs358303 -- 140,406,441(+) ATTTT(C/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLGN Gene

Variant ID Type Subtype PubMed ID
nsv880165 CNV Loss 21882294

Variation tolerance for CLGN Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.10; 84.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLGN Gene

HapMap Linkage Disequilibrium report
CLGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLGN Gene

Disorders for CLGN Gene

Relevant External Links for CLGN

Genetic Association Database (GAD)
CLGN
Human Genome Epidemiology (HuGE) Navigator
CLGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLGN

No disorders were found for CLGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLGN Gene

Publications for CLGN Gene

  1. Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone. (PMID: 9434179) Tanaka H. … Nishimune Y. (Gene 1997) 3 4 23 67
  2. Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase. (PMID: 16264275) Kim D.H. … Kwon H.J. (Exp. Mol. Med. 2005) 3 23
  3. The putative chaperone calmegin is required for sperm fertility. (PMID: 9177349) Ikawa M. … Okabe M. (Nature 1997) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CLGN Gene

Sources for CLGN Gene

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