Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CLGN Gene

Aliases for CLGN Gene

  • Calmegin 2 3 3 5
  • Testis Tissue Sperm-Binding Protein Li 79P 3

External Ids for CLGN Gene

Previous GeneCards Identifiers for CLGN Gene

  • GC04M142172
  • GC04M141626
  • GC04M141775
  • GC04M141887
  • GC04M141667
  • GC04M141529
  • GC04M141309
  • GC04M137040

Summaries for CLGN Gene

Entrez Gene Summary for CLGN Gene

  • Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLGN Gene

CLGN (Calmegin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein binding involved in protein folding. An important paralog of this gene is CANX.

UniProtKB/Swiss-Prot for CLGN Gene

  • Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Wiki entry for CLGN Gene

Additional gene information for CLGN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLGN Gene

Genomics for CLGN Gene

Regulatory Elements for CLGN Gene

Enhancers for CLGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H140372 1 ENCODE 19.4 +54.3 54338 2 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CLGN UCP1 SCOC-AS1
GH04H140426 1 ENCODE 18.3 +0.6 558 1 PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ETS1 GLIS2 MXD4 CLGN ELMOD2 SCOC-AS1
GH04H140529 1 ENCODE 18.1 -101.7 -101716 0 PKNOX1 FOXA2 ATF1 ARNT ARID4B DMAP1 TCF12 ZNF766 GATA2 ATF7 CLGN UCP1 ELMOD2
GH04H140362 0.9 ENCODE 18.7 +64.6 64646 1 ELF3 ATF1 INSM2 ARID4B FEZF1 RAD21 RARA ZSCAN5C MIXL1 TSHZ1 CLGN UCP1 RPL14P3 NDUFB4P9
GH04H140342 0.6 ENCODE 22.9 +84.5 84531 1 OSR2 NFIC NFIA NFIB ZNF10 ZNF266 ELF1 YY1 CLGN MAML3 ELMOD2 RPL14P3 NDUFB4P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLGN on UCSC Golden Path with GeneCards custom track

Promoters for CLGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173870 568 1201 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 GLIS2 MXD4 REST SSRP1

Genomic Location for CLGN Gene

Chromosome:
4
Start:
140,388,453 bp from pter
End:
140,427,968 bp from pter
Size:
39,516 bases
Orientation:
Minus strand

Genomic View for CLGN Gene

Genes around CLGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLGN Gene

Proteins for CLGN Gene

  • Protein details for CLGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14967-CLGN_HUMAN
    Recommended name:
    Calmegin
    Protein Accession:
    O14967
    Secondary Accessions:
    • B3KS90
    • B4DXV8
    • D3DNY8

    Protein attributes for CLGN Gene

    Size:
    610 amino acids
    Molecular mass:
    70039 Da
    Quaternary structure:
    • Interacts with PPIB. Interacts with ADAM2 (By similarity). Interacts with PDILT.

    Alternative splice isoforms for CLGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLGN Gene

Post-translational modifications for CLGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLGN Gene

No data available for DME Specific Peptides for CLGN Gene

Domains & Families for CLGN Gene

Gene Families for CLGN Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CLGN Gene

Suggested Antigen Peptide Sequences for CLGN Gene

Graphical View of Domain Structure for InterPro Entry

O14967

UniProtKB/Swiss-Prot:

CLGN_HUMAN :
  • Belongs to the calreticulin family.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CLGN: view

Function for CLGN Gene

Molecular function for CLGN Gene

UniProtKB/Swiss-Prot Function:
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Ontology (GO) - Molecular Function for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 26638075
GO:0044183 protein binding involved in protein folding IEA --
GO:0051082 unfolded protein binding IEA,TAS --
genes like me logo Genes that share ontologies with CLGN: view
genes like me logo Genes that share phenotypes with CLGN: view

Animal Models for CLGN Gene

MGI Knock Outs for CLGN:

Animal Model Products

CRISPR Products

miRNA for CLGN Gene

miRTarBase miRNAs that target CLGN

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLGN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLGN Gene

Localization for CLGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLGN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLGN gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA,TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLGN: view

Pathways & Interactions for CLGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006461 protein complex assembly IEA --
GO:0007338 single fertilization TAS 9177349
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with CLGN: view

No data available for Pathways by source and SIGNOR curated interactions for CLGN Gene

Drugs & Compounds for CLGN Gene

(1) Drugs for CLGN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLGN: view

Transcripts for CLGN Gene

Unigene Clusters for CLGN Gene

Calmegin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CLGN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CLGN Gene

No ASD Table

Relevant External Links for CLGN Gene

GeneLoc Exon Structure for
CLGN
ECgene alternative splicing isoforms for
CLGN

Expression for CLGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLGN Gene

This gene is overexpressed in Heart - Left Ventricle (x11.6), Testis (x11.1), and Heart - Atrial Appendage (x8.4).

Protein differential expression in normal tissues from HIPED for CLGN Gene

This gene is overexpressed in Ovary (54.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLGN Gene



NURSA nuclear receptor signaling pathways regulating expression of CLGN Gene:

CLGN

SOURCE GeneReport for Unigene cluster for CLGN Gene:

Hs.86368

mRNA Expression by UniProt/SwissProt for CLGN Gene:

O14967-CLGN_HUMAN
Tissue specificity: Detected in testis (at protein level). Detected in testis.

Evidence on tissue expression from TISSUES for CLGN Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with CLGN: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLGN Gene

Orthologs for CLGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLGN 33
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia CLGN 33 34
  • 92.08 (n)
cow
(Bos Taurus)
Mammalia CLGN 33 34
  • 90.7 (n)
mouse
(Mus musculus)
Mammalia Clgn 33 16 34
  • 79.37 (n)
rat
(Rattus norvegicus)
Mammalia Clgn 33
  • 78.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CLGN 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLGN 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLGN 33 34
  • 72.06 (n)
lizard
(Anolis carolinensis)
Reptilia CLGN 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clgn 33
  • 67.01 (n)
zebrafish
(Danio rerio)
Actinopterygii clgn 33 34
  • 65.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cnx99A 35 34
  • 58 (a)
CG1924 35 34
  • 47 (a)
CG9906 35
  • 45 (a)
Cnx14D 34
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cnx-1 35 34
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 34
  • 28 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnx1 33
  • 57.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09265 33
  • 49.84 (n)
Species where no ortholog for CLGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLGN Gene

ENSEMBL:
Gene Tree for CLGN (if available)
TreeFam:
Gene Tree for CLGN (if available)

Paralogs for CLGN Gene

Paralogs for CLGN Gene

(2) SIMAP similar genes for CLGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLGN: view

Variants for CLGN Gene

Sequence variations from dbSNP and Humsavar for CLGN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000180732 -- 140,413,150(+) GTATA(C/T)GTAGA intron-variant
rs1000270046 -- 140,405,372(+) GTAGA(G/T)ACGGG intron-variant
rs1000359321 -- 140,424,198(+) AAGTT(G/T)TGGTA intron-variant
rs1000374276 -- 140,423,780(+) ATCCA(C/T)TTAAT intron-variant
rs1000374823 -- 140,413,363(+) ATGGC(C/G/T)GAATA intron-variant

Variation tolerance for CLGN Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.10; 84.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLGN Gene

Disorders for CLGN Gene

Relevant External Links for CLGN

Genetic Association Database (GAD)
CLGN
Human Genome Epidemiology (HuGE) Navigator
CLGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLGN

No disorders were found for CLGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLGN Gene

Publications for CLGN Gene

  1. Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone. (PMID: 9434179) Tanaka H … Nishimune Y (Gene 1997) 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 3 45 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase. (PMID: 16264275) Kim DH … Kwon HJ (Experimental & molecular medicine 2005) 3 22 60

Products for CLGN Gene

Sources for CLGN Gene

Content
Loading form....