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Aliases for CLGN Gene

Aliases for CLGN Gene

  • Calmegin 2 3

External Ids for CLGN Gene

Summaries for CLGN Gene

Entrez Gene Summary for CLGN Gene

  • Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLGN Gene

CLGN (Calmegin) is a Protein Coding gene. Diseases associated with CLGN include infertility. GO annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is CALR.

UniProtKB/Swiss-Prot for CLGN Gene

  • Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Wiki entry for CLGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLGN Gene

Genomics for CLGN Gene

Genomic Location for CLGN Gene

Start:
140,388,453 bp from pter
End:
140,427,968 bp from pter
Size:
39,516 bases
Orientation:
Minus strand

Genomic View for CLGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLGN Gene

Regulatory Elements for CLGN Gene

Proteins for CLGN Gene

  • Protein details for CLGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14967-CLGN_HUMAN
    Recommended name:
    Calmegin
    Protein Accession:
    O14967
    Secondary Accessions:
    • B3KS90
    • B4DXV8
    • D3DNY8

    Protein attributes for CLGN Gene

    Size:
    610 amino acids
    Molecular mass:
    70039 Da
    Quaternary structure:
    • Interacts with PPIB. Interacts with ADAM2 (By similarity). Interacts with PDILT.

    Alternative splice isoforms for CLGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLGN Gene

Proteomics data for CLGN Gene at MOPED

Post-translational modifications for CLGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLGN Gene

No data available for DME Specific Peptides for CLGN Gene

Domains for CLGN Gene

Protein Domains for CLGN Gene

Suggested Antigen Peptide Sequences for CLGN Gene

Graphical View of Domain Structure for InterPro Entry

O14967

UniProtKB/Swiss-Prot:

CLGN_HUMAN
Family:
  • Belongs to the calreticulin family.:
    • O14967
genes like me logo Genes that share domains with CLGN: view

No data available for Gene Families for CLGN Gene

Function for CLGN Gene

Molecular function for CLGN Gene

UniProtKB/Swiss-Prot Function: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).

Gene Ontology (GO) - Molecular Function for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0044183 protein binding involved in protein folding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CLGN: view

Phenotypes for CLGN Gene

MGI mutant phenotypes for CLGN:
inferred from 2 alleles
GenomeRNAi human phenotypes for CLGN:
genes like me logo Genes that share phenotypes with CLGN: view

Animal Models for CLGN Gene

MGI Knock Outs for CLGN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CLGN Gene

Localization for CLGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLGN Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLGN Gene COMPARTMENTS Subcellular localization image for CLGN gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLGN: view

Pathways for CLGN Gene

SuperPathways for CLGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006461 protein complex assembly IEA --
GO:0007338 single fertilization TAS 9177349
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with CLGN: view

No data available for Pathways by source for CLGN Gene

Compounds for CLGN Gene

(1) HMDB Compounds for CLGN Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CLGN: view

Transcripts for CLGN Gene

Unigene Clusters for CLGN Gene

Calmegin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLGN Gene

No ASD Table

Relevant External Links for CLGN Gene

GeneLoc Exon Structure for
CLGN
ECgene alternative splicing isoforms for
CLGN

Expression for CLGN Gene

mRNA expression in normal human tissues for CLGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLGN Gene

This gene is overexpressed in Heart - Left Ventricle (11.6), Testis (11.1), and Heart - Atrial Appendage (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLGN Gene

SOURCE GeneReport for Unigene cluster for CLGN Gene Hs.86368

mRNA Expression by UniProt/SwissProt for CLGN Gene

O14967-CLGN_HUMAN
Tissue specificity: Detected in testis (at protein level). Detected in testis.
genes like me logo Genes that share expressions with CLGN: view

Orthologs for CLGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CLGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLGN 35
  • 99.65 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia CLGN 35
  • 90.7 (n)
  • 87.13 (a)
CLGN 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLGN 35
  • 92.08 (n)
  • 89.84 (a)
CLGN 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clgn 35
  • 79.37 (n)
  • 77.5 (a)
Clgn 16
Clgn 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLGN 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLGN 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clgn 35
  • 78.16 (n)
  • 77.83 (a)
chicken
(Gallus gallus)
Aves CLGN 35
  • 72.06 (n)
  • 66.83 (a)
CLGN 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLGN 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clgn 35
  • 67.01 (n)
  • 60.55 (a)
zebrafish
(Danio rerio)
Actinopterygii clgn 35
  • 65.13 (n)
  • 62.77 (a)
clgn 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1924 36
  • 41 (a)
ManyToMany
Cnx14D 36
  • 43 (a)
ManyToMany
Cnx99A 36
  • 42 (a)
ManyToMany
CG1924 37
  • 47 (a)
Cnx99A 37
  • 58 (a)
CG9906 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea cnx-1 36
  • 36 (a)
OneToMany
cnx-1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 36
  • 28 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09265 35
  • 49.84 (n)
  • 46.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnx1 35
  • 57.13 (n)
  • 47.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CLGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLGN Gene

ENSEMBL:
Gene Tree for CLGN (if available)
TreeFam:
Gene Tree for CLGN (if available)

Paralogs for CLGN Gene

Paralogs for CLGN Gene

Selected SIMAP similar genes for CLGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLGN: view

Variants for CLGN Gene

Sequence variations from dbSNP and Humsavar for CLGN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs191678 -- 140,395,167(+) ttttt(G/T)ttttg intron-variant
rs358298 -- 140,404,057(+) ctaac(A/G)tacTT intron-variant
rs358299 -- 140,404,163(+) atctc(A/G)gctca intron-variant
rs358300 -- 140,404,255(+) caccc(A/G)gctaa intron-variant
rs358301 -- 140,404,378(+) gtgaa(C/G)cactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLGN Gene

Variant ID Type Subtype PubMed ID
nsv880165 CNV Loss 21882294

Relevant External Links for CLGN Gene

HapMap Linkage Disequilibrium report
CLGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLGN Gene

Disorders for CLGN Gene

(1) MalaCards Diseases for CLGN Gene

Search for CLGN Gene in MalaCards »

Relevant External Links for CLGN

Genetic Association Database (GAD)
CLGN
Human Genome Epidemiology (HuGE) Navigator
CLGN
genes like me logo Genes that share disorders with CLGN: view

No data available for UniProtKB/Swiss-Prot for CLGN Gene

Publications for CLGN Gene

  1. Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone. (PMID: 9434179) Tanaka H. … Nishimune Y. (Gene 1997) 3 4 23
  2. Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase. (PMID: 16264275) Kim D.H. … Kwon H.J. (Exp. Mol. Med. 2005) 3 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CLGN Gene

Sources for CLGN Gene

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