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Aliases for CLECL1 Gene

Aliases for CLECL1 Gene

  • C-Type Lectin Like 1 2 3 5
  • Dendritic Cell Associated Lectin 1 2 3
  • Dendritic Cell-Associated Lectin 1 3 4
  • DC-Associated Lectin-1 3 4
  • C-Type Lectin-Like 1 2 3
  • DCAL-1 3 4
  • DCAL1 3 4
  • Type II Transmembrane Protein DCAL1 3
  • Dendritic Cell-Associated Lectin-1 3

External Ids for CLECL1 Gene

Previous GeneCards Identifiers for CLECL1 Gene

  • GC12M009767
  • GC12M009875
  • GC12M009618
  • GC12M009964
  • GC12M010063
  • GC12M010257
  • GC12M010499
  • GC12M009807
  • GC12M010164

Summaries for CLECL1 Gene

Entrez Gene Summary for CLECL1 Gene

  • This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CLECL1 Gene

CLECL1 (C-Type Lectin Like 1) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for CLECL1 Gene

  • May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLECL1 Gene

Genomics for CLECL1 Gene

Regulatory Elements for CLECL1 Gene

Promoters for CLECL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLECL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLECL1 Gene

Chromosome:
12
Start:
9,715,860 bp from pter
End:
9,733,299 bp from pter
Size:
17,440 bases
Orientation:
Minus strand

Genomic View for CLECL1 Gene

Genes around CLECL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLECL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLECL1 Gene

Proteins for CLECL1 Gene

  • Protein details for CLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS7-CLCL1_HUMAN
    Recommended name:
    C-type lectin-like domain family 1
    Protein Accession:
    Q8IZS7

    Protein attributes for CLECL1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19115 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLECL1 Gene

Proteomics data for CLECL1 Gene at MOPED

Post-translational modifications for CLECL1 Gene

  • Glycosylation at Asn 109, Asn 140, and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for CLECL1 Gene

Antibody Products

No data available for DME Specific Peptides for CLECL1 Gene

Domains & Families for CLECL1 Gene

Protein Domains for CLECL1 Gene

Suggested Antigen Peptide Sequences for CLECL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZS7

UniProtKB/Swiss-Prot:

CLCL1_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLECL1: view

No data available for Gene Families for CLECL1 Gene

Function for CLECL1 Gene

Molecular function for CLECL1 Gene

UniProtKB/Swiss-Prot Function:
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.
genes like me logo Genes that share phenotypes with CLECL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLECL1 Gene

Localization for CLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLECL1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLECL1 Gene COMPARTMENTS Subcellular localization image for CLECL1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CLECL1: view

Pathways & Interactions for CLECL1 Gene

SuperPathways for CLECL1 Gene

No Data Available

Interacting Proteins for CLECL1 Gene

Gene Ontology (GO) - Biological Process for CLECL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLECL1 Gene

Drugs & Compounds for CLECL1 Gene

No Compound Related Data Available

Transcripts for CLECL1 Gene

mRNA/cDNA for CLECL1 Gene

Unigene Clusters for CLECL1 Gene

C-type lectin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLECL1 Gene

No ASD Table

Relevant External Links for CLECL1 Gene

GeneLoc Exon Structure for
CLECL1
ECgene alternative splicing isoforms for
CLECL1

Expression for CLECL1 Gene

mRNA expression in normal human tissues for CLECL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLECL1 Gene

This gene is overexpressed in Spleen (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLECL1 Gene



SOURCE GeneReport for Unigene cluster for CLECL1 Gene Hs.560087

mRNA Expression by UniProt/SwissProt for CLECL1 Gene

Q8IZS7-CLCL1_HUMAN
Tissue specificity: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.
genes like me logo Genes that share expression patterns with CLECL1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for CLECL1 Gene

Orthologs for CLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLECL1 35
  • 98.43 (n)
  • 96.34 (a)
CLECL1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLECL1 36
  • 18 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
Species with no ortholog for CLECL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLECL1 Gene

ENSEMBL:
Gene Tree for CLECL1 (if available)
TreeFam:
Gene Tree for CLECL1 (if available)

Paralogs for CLECL1 Gene

No data available for Paralogs for CLECL1 Gene

Variants for CLECL1 Gene

Sequence variations from dbSNP and Humsavar for CLECL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2080206 -- 9,715,370(-) TAGTC(A/G)TTCTC downstream-variant-500B
rs2268145 -- 9,716,918(-) GTGGG(C/G)GTGTG intron-variant, downstream-variant-500B
rs2268146 -- 9,716,675(-) CTTCT(C/T)AGGAA utr-variant-3-prime
rs2401394 -- 9,726,830(+) ATAAT(A/G)TCTCA intron-variant
rs4763835 -- 9,728,560(+) GAAGA(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLECL1 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
dgv468e1 CNV Complex 17122850
dgv474e1 CNV Complex 17122850

Variation tolerance for CLECL1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLECL1 Gene

HapMap Linkage Disequilibrium report
CLECL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLECL1 Gene

Disorders for CLECL1 Gene

Relevant External Links for CLECL1

Genetic Association Database (GAD)
CLECL1
Human Genome Epidemiology (HuGE) Navigator
CLECL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLECL1

No disorders were found for CLECL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLECL1 Gene

Publications for CLECL1 Gene

  1. Dendritic cell-associated lectin-1: a novel dendritic cell- associated, C-type lectin-like molecule enhances T cell secretion of IL-4. (PMID: 12421943) Ryan E.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 23 67
  2. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. (PMID: 19027044) Ryan E.J. … Clark E.A. (Hum. Immunol. 2009) 3 23
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3
  4. Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. (PMID: 19648166) Zhao X. … Korver W. (Haematologica 2010) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for CLECL1 Gene

Sources for CLECL1 Gene

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