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Aliases for CLECL1 Gene

Aliases for CLECL1 Gene

  • C-Type Lectin Like 1 2 3 5
  • Dendritic Cell-Associated Lectin 1 3 4
  • DC-Associated Lectin-1 3 4
  • DCAL-1 3 4
  • DCAL1 3 4
  • Type II Transmembrane Protein DCAL1 3
  • Dendritic Cell Associated Lectin 1 2
  • C-Type Lectin-Like Domain Family 1 3
  • C-Type Lectin-Like 1 2

External Ids for CLECL1 Gene

Previous GeneCards Identifiers for CLECL1 Gene

  • GC12M009767
  • GC12M009875
  • GC12M009618
  • GC12M009964
  • GC12M010063
  • GC12M010257
  • GC12M010499
  • GC12M009807
  • GC12M010164
  • GC12M010759
  • GC12M010992

Summaries for CLECL1 Gene

Entrez Gene Summary for CLECL1 Gene

  • This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CLECL1 Gene

CLECL1 (C-Type Lectin Like 1) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for CLECL1 Gene

  • May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLECL1 Gene

Genomics for CLECL1 Gene

Regulatory Elements for CLECL1 Gene

Enhancers for CLECL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F009720 1.2 FANTOM5 Ensembl ENCODE 38.5 +6.1 6121 13.2 TBP PKNOX1 BMI1 CBX5 FOS SMAD5 CEBPB JUNB TBX21 PBX2 CLECL1 KLRB1 ENSG00000213443 ENSG00000257027 OLR1 CLEC12A CD69 CLEC7A LOC101930452 LOC374443
GH12F009701 1.6 FANTOM5 Ensembl ENCODE 33 +30.8 30769 2.3 ZFHX2 ZFP64 ZNF781 ZNF518A EGR2 CLECL1 CLEC2D KLRB1 ENSG00000213443 PHC1 ENSG00000257027 LOC374443 DDX12P CD69 CLEC2B
GH12F009705 1 Ensembl ENCODE 30.3 +26.0 25978 3.4 CTCF ZNF654 MIER1 OVOL3 JUNB TRIM22 EBF1 REST RAD21 ZNF316 CLECL1 PHC1 KLRA1P CLEC2D ENSG00000257027 ENSG00000213443 KLRB1 MAGOHB LOC374443 LOC105369652
GH12F009698 0.7 Ensembl ENCODE 28.2 +33.6 33599 2.6 ATF3 POLR2A CEBPB CLECL1 ENSG00000257027 CLEC2D ENSG00000213443 KLRB1 LOC374443 LOC100506159 LOC105369652 PIR44219
GH12F009736 1.4 FANTOM5 Ensembl ENCODE 25.6 -6.7 -6724 7.6 PKNOX1 GATA2 CBX5 ZNF143 JUNB TBX21 MEF2D SMARCA4 HMBOX1 STAT3 CLECL1 CLEC2D KLRB1 ENSG00000213443 ENSG00000214776 CD69 CLEC7A ENSG00000257027 CLEC2B KLRF1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CLECL1 on UCSC Golden Path with GeneCards custom track

Promoters for CLECL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001025342 299 401 SMAD5 CHD1 JUNB TBX21 RELA POLR2A IKZF1 TARDBP TCF7 ZBTB33
ENSR00001774843 1299 1201 TBP MAFG CHD1 ZNF316 NFE2L1 NFE2 ZBTB33 EMSY SPI1

Genomic Location for CLECL1 Gene

Chromosome:
12
Start:
9,715,860 bp from pter
End:
9,733,299 bp from pter
Size:
17,440 bases
Orientation:
Minus strand

Genomic View for CLECL1 Gene

Genes around CLECL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLECL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLECL1 Gene

Proteins for CLECL1 Gene

  • Protein details for CLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS7-CLCL1_HUMAN
    Recommended name:
    C-type lectin-like domain family 1
    Protein Accession:
    Q8IZS7

    Protein attributes for CLECL1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19115 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLECL1 Gene

Post-translational modifications for CLECL1 Gene

  • Glycosylation at Asn 109, Asn 140, and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for CLECL1 Gene

Antibody Products

No data available for DME Specific Peptides for CLECL1 Gene

Domains & Families for CLECL1 Gene

Protein Domains for CLECL1 Gene

Suggested Antigen Peptide Sequences for CLECL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZS7

UniProtKB/Swiss-Prot:

CLCL1_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLECL1: view

No data available for Gene Families for CLECL1 Gene

Function for CLECL1 Gene

Molecular function for CLECL1 Gene

UniProtKB/Swiss-Prot Function:
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

Gene Ontology (GO) - Molecular Function for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLECL1: view
genes like me logo Genes that share phenotypes with CLECL1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CLECL1 Gene

Localization for CLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLECL1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLECL1 Gene COMPARTMENTS Subcellular localization image for CLECL1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLECL1: view

Pathways & Interactions for CLECL1 Gene

SuperPathways for CLECL1 Gene

No Data Available

Interacting Proteins for CLECL1 Gene

Gene Ontology (GO) - Biological Process for CLECL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CLECL1 Gene

Transcripts for CLECL1 Gene

mRNA/cDNA for CLECL1 Gene

Unigene Clusters for CLECL1 Gene

C-type lectin-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLECL1 Gene

No ASD Table

Relevant External Links for CLECL1 Gene

GeneLoc Exon Structure for
CLECL1
ECgene alternative splicing isoforms for
CLECL1

Expression for CLECL1 Gene

mRNA expression in normal human tissues for CLECL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLECL1 Gene

This gene is overexpressed in Spleen (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLECL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CLECL1 Gene:

CLECL1

SOURCE GeneReport for Unigene cluster for CLECL1 Gene:

Hs.560087

mRNA Expression by UniProt/SwissProt for CLECL1 Gene:

Q8IZS7-CLCL1_HUMAN
Tissue specificity: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.
genes like me logo Genes that share expression patterns with CLECL1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for CLECL1 Gene

Orthologs for CLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLECL1 34 35
  • 98.43 (n)
cow
(Bos Taurus)
Mammalia CLECL1 35
  • 18 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 18 (a)
OneToMany
-- 35
  • 18 (a)
OneToMany
-- 35
  • 14 (a)
OneToMany
-- 35
  • 13 (a)
OneToMany
Species where no ortholog for CLECL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLECL1 Gene

ENSEMBL:
Gene Tree for CLECL1 (if available)
TreeFam:
Gene Tree for CLECL1 (if available)

Paralogs for CLECL1 Gene

No data available for Paralogs for CLECL1 Gene

Variants for CLECL1 Gene

Sequence variations from dbSNP and Humsavar for CLECL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1008610 -- 9,731,264(+) CGATT(C/G)ATTTA intron-variant
rs1008611 -- 9,731,563(+) CTTTC(C/G)CTTGA intron-variant
rs10161013 -- 9,732,210(+) AAATA(C/T)AAAGG intron-variant
rs10466829 -- 9,723,495(+) agagt(A/G)aacaa intron-variant
rs10492165 -- 9,733,365(+) TATAG(A/G)CCACT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CLECL1 Gene

Variant ID Type Subtype PubMed ID
esv2651553 CNV insertion 19546169
esv2759878 CNV gain+loss 17122850
esv3443832 CNV insertion 20981092
esv3628513 CNV loss 21293372
esv3628514 CNV gain 21293372
nsv1051530 CNV gain 25217958
nsv442255 CNV loss 18776908
nsv8910 CNV gain 18304495

Variation tolerance for CLECL1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLECL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLECL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLECL1 Gene

Disorders for CLECL1 Gene

Relevant External Links for CLECL1

Genetic Association Database (GAD)
CLECL1
Human Genome Epidemiology (HuGE) Navigator
CLECL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLECL1

No disorders were found for CLECL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLECL1 Gene

Publications for CLECL1 Gene

  1. Dendritic cell-associated lectin-1: a novel dendritic cell- associated, C-type lectin-like molecule enhances T cell secretion of IL-4. (PMID: 12421943) Ryan E.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 22 64
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  3. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. (PMID: 19027044) Ryan E.J. … Clark E.A. (Hum. Immunol. 2009) 3 22 64
  4. Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. (PMID: 19648166) Zhao X. … Korver W. (Haematologica 2010) 3 64
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64

Products for CLECL1 Gene

Sources for CLECL1 Gene

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