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Aliases for CLECL1 Gene

Aliases for CLECL1 Gene

  • C-Type Lectin-Like 1 2 3
  • DCAL1 3 4 6
  • Dendritic Cell Associated Lectin 1 2 3
  • Dendritic Cell-Associated Lectin 1 3 4
  • DC-Associated Lectin-1 3 4
  • DCAL-1 3 4
  • Type II Transmembrane Protein DCAL1 3
  • C-Type Lectin-Like Domain Family 1 3
  • Dendritic Cell-Associated Lectin-1 3

External Ids for CLECL1 Gene

Previous GeneCards Identifiers for CLECL1 Gene

  • GC12M009767
  • GC12M009875
  • GC12M009618
  • GC12M009964
  • GC12M010063
  • GC12M010257
  • GC12M010499

Summaries for CLECL1 Gene

Entrez Gene Summary for CLECL1 Gene

  • This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CLECL1 Gene

CLECL1 (C-Type Lectin-Like 1) is a Protein Coding gene. An important paralog of this gene is KLRF2.

UniProtKB/Swiss-Prot for CLECL1 Gene

  • May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLECL1 Gene

Genomics for CLECL1 Gene

Regulatory Elements for CLECL1 Gene

Genomic Location for CLECL1 Gene

Start:
9,696,777 bp from pter
End:
9,733,299 bp from pter
Size:
36,523 bases
Orientation:
Minus strand

Genomic View for CLECL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLECL1 Gene

Proteins for CLECL1 Gene

  • Protein details for CLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS7-CLCL1_HUMAN
    Recommended name:
    C-type lectin-like domain family 1
    Protein Accession:
    Q8IZS7
    Secondary Accessions:

    Protein attributes for CLECL1 Gene

    Size:
    167 amino acids
    Molecular mass:
    19115 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CLECL1 Gene

Proteomics data for CLECL1 Gene at MOPED

Post-translational modifications for CLECL1 Gene

  • Glycosylation at Asn109, Asn140, and Asn149
  • Modification sites at PhosphoSitePlus

Other Protein References for CLECL1 Gene

No data available for DME Specific Peptides for CLECL1 Gene

Domains for CLECL1 Gene

Protein Domains for CLECL1 Gene

Suggested Antigen Peptide Sequences for CLECL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZS7

UniProtKB/Swiss-Prot:

CLCL1_HUMAN :
  • Q8IZS7
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLECL1: view

No data available for Gene Families for CLECL1 Gene

Function for CLECL1 Gene

Molecular function for CLECL1 Gene

UniProtKB/Swiss-Prot Function: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.

Gene Ontology (GO) - Molecular Function for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLECL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CLECL1 Gene

Localization for CLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLECL1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLECL1 Gene COMPARTMENTS Subcellular localization image for CLECL1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLECL1: view

Pathways for CLECL1 Gene

SuperPathways for CLECL1 Gene

No Data Available

Interacting Proteins for CLECL1 Gene

Gene Ontology (GO) - Biological Process for CLECL1 Gene

None

No data available for Pathways by source for CLECL1 Gene

Transcripts for CLECL1 Gene

mRNA/cDNA for CLECL1 Gene

Unigene Clusters for CLECL1 Gene

C-type lectin-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLECL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CLECL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLECL1 Gene

No ASD Table

Relevant External Links for CLECL1 Gene

GeneLoc Exon Structure for
CLECL1
ECgene alternative splicing isoforms for
CLECL1

Expression for CLECL1 Gene

mRNA expression in normal human tissues for CLECL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLECL1 Gene

This gene is overexpressed in Spleen (4.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CLECL1 Gene

SOURCE GeneReport for Unigene cluster for CLECL1 Gene Hs.560087

mRNA Expression by UniProt/SwissProt for CLECL1 Gene

Q8IZS7-CLCL1_HUMAN
Tissue specificity: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.
genes like me logo Genes that share expressions with CLECL1: view

In Situ Assay Products

Orthologs for CLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLECL1 35
  • 98.43 (n)
  • 96.34 (a)
CLECL1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLECL1 36
  • 18 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 14 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
Species with no ortholog for CLECL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLECL1 Gene

ENSEMBL:
Gene Tree for CLECL1 (if available)
TreeFam:
Gene Tree for CLECL1 (if available)

Paralogs for CLECL1 Gene

Paralogs for CLECL1 Gene

genes like me logo Genes that share paralogs with CLECL1: view

Variants for CLECL1 Gene

Sequence variations from dbSNP and Humsavar for CLECL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs741199 -- 9,720,769(-) CACCA(C/T)CTCTC intron-variant
rs741200 -- 9,717,819(+) tagtg(G/T)aagtc intron-variant
rs917913 -- 9,707,040(-) ACCAA(C/T)CATGA intron-variant
rs982511 -- 9,729,732(-) CCTCT(C/T)ACCAT intron-variant
rs1008610 -- 9,731,264(+) CGATT(C/G)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLECL1 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
dgv468e1 CNV Complex 17122850
dgv474e1 CNV Complex 17122850

Relevant External Links for CLECL1 Gene

HapMap Linkage Disequilibrium report
CLECL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLECL1 Gene

Disorders for CLECL1 Gene

Relevant External Links for CLECL1

Genetic Association Database (GAD)
CLECL1
Human Genome Epidemiology (HuGE) Navigator
CLECL1
genes like me logo Genes that share disorders with CLECL1: view

No data available for UniProtKB/Swiss-Prot for CLECL1 Gene

Publications for CLECL1 Gene

  1. Dendritic cell-associated lectin-1: a novel dendritic cell- associated, C-type lectin-like molecule enhances T cell secretion of IL-4. (PMID: 12421943) Ryan E.J. … Clark E.A. (J. Immunol. 2002) 2 3 4 23
  2. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. (PMID: 19027044) Ryan E.J. … Clark E.A. (Hum. Immunol. 2009) 3 23
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CLECL1 Gene

Sources for CLECL1 Gene

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