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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CLECL1 Gene

protein-coding   GIFtS: 44
GCID: GC12M010257

C-Type Lectin-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Type Lectin-Like 11 2     DC-Associated Lectin-12 3
Dendritic Cell Associated Lectin 11 2     C-Type Lectin-Like Domain Family 12
Dendritic Cell-Associated Lectin 12 3     Dendritic Cell-Associated Lectin-12
DCAL-12 3     Type II Transmembrane Protein DCAL12
DCAL12 3     

External Ids:    HGNC: 244621   Entrez Gene: 1603652   Ensembl: ENSG000001842937   OMIM: 6074675   UniProtKB: Q8IZS73   

Export aliases for CLECL1 gene to outside databases

Previous GC identifers: GC12M009767 GC12M009875 GC12M009618 GC12M009964 GC12M010063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLECL1 Gene:
This gene encodes a type II transmembrane, C-type lectin-like protein that is highly expressed on dendritic and B
cells. This protein may act as a T-cell costimulatory molecule that enhances interleukin-4 production, and maybe
involved in the regulation of the immune response. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CLECL1 Gene: 
CLECL1 (C-type lectin-like 1) is a protein-coding gene. Diseases associated with CLECL1 include tonsillitis, and acute myeloid leukemia.

UniProtKB/Swiss-Prot: CLCL1_HUMAN, Q8IZS7
Function: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule,
enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and
the cells of the adaptive immune response




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLECL1 gene promoter:
         MEF-2A   CHOP-10   AREB6   p53   NCX/Ncx   aMEF-2   STAT5A   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCLECL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CLECL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CLECL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CLECL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLECL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010257:  view genomic region     (about GC identifiers)

Start:
9,868,456 bp from pter      End:
9,885,895 bp from pter
Size:
17,440 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: CLCL1_HUMAN, Q8IZS7 (See protein sequence)
Recommended Name: C-type lectin-like domain family 1  
Size: 167 amino acids; 19115 Da
Subcellular location: Cell membrane; Single-pass type II membrane protein

Explore the universe of human proteins at neXtProt for CLECL1: NX_Q8IZS7

Explore proteomics data for CLECL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZS7

  • CLECL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CLECL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001240679.1  NP_001254630.1  NP_742001.1  

    ENSEMBL proteins: 
     ENSP00000444947   ENSP00000438981   ENSP00000331766  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CLECL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like

    Graphical View of Domain Structure for InterPro Entry Q8IZS7

    ProtoNet protein and cluster: Q8IZS7

    UniProtKB/Swiss-Prot: CLCL1_HUMAN, Q8IZS7
    Similarity: Contains 1 C-type lectin domain


    CLECL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLCL1_HUMAN, Q8IZS7
    Function: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule,
    enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and
    the cells of the adaptive immune response

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLECL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLECL1 (CLCL1)

    Search CenterWatch for drugs/clinical trials and news about CLECL1 / CLCL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CLECL1 gene (3 alternative transcripts): 
    NM_001253750.1  NM_001267701.1  NM_172004.3  

    Unigene Clusters for CLECL1:

    C-type lectin-like 1
    Hs.560087  [show with all ESTs], Hs.734740  [show with all ESTs]
    Unigene Representative Sequences: BC042176, NM_001253750
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540988(uc001qwi.3) ENST00000542530 ENST00000327839(uc001qwj.3)

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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CLECL1

    Additional mRNA sequence: 

    AF518873.1 BC093857.1 BC093859.1 

    4 DOTS entries:

    DT.70104497  DT.91972933  DT.99966855  DT.121142159 

    16 AceView cDNA sequences:

    AI719511 AF518873 AA746003 AW237307 NM_172004 BX103210 BC042176 BG258759 
    BG391235 AI879793 BG391322 CD641524 AI271437 BU430089 BG213959 BG391532 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CLECL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGATGAGT
    CLECL1 Expression
    About this image


    See CLECL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CLECL1

    SOURCE GeneReport for Unigene clusters: Hs.560087 Hs.734740

    UniProtKB/Swiss-Prot: CLCL1_HUMAN, Q8IZS7
    Tissue specificity: Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone
    marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CLECL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for CLECL1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia CLECL11 C-type lectin-like 1 98.16(n)
    95.71(a)
      736724  XM_001136753.3  XP_001136753.3 


    ENSEMBL Gene Tree for CLECL1 (if available)
    TreeFam Gene Tree for CLECL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 SNPs in CLECL1 are shown (see all 474)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20802061,2
    C,F,A,H--9867966(-) TAGTCG/ATTCTC 2 -- ds50018Minor allele frequency- A:0.38NA WA EA 370
    rs1498416471,2
    --9867981(+) TTAGTC/TTTACT 2 -- ds50010--------
    rs1468603801,2
    --9868155(+) CCTACC/GTCAGT 2 -- ds50010--------
    rs1396872821,2
    C--9868168(+) CCTGAC/TGTATG 2 -- ds50010--------
    rs122276551,2
    C,F,H--9868248(+) ACAAAT/GTTTTG 2 -- ds500110Minor allele frequency- G:0.26NS EA WA NA 772
    rs1123669731,2
    C--9868270(+) CTCTAT/CCTCCA 2 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs122286411,2
    C,F--9868276(+) CTCCAG/ACATCC 2 -- ds500110Minor allele frequency- A:0.27NA WA CSA EA 371
    rs1466901941,2
    C--9868401(+) CATCAC/TTGGTT 2 -- ds50010--------
    rs1488408351,2
    --9868476(+) GGGTCC/TGGTTC 2 -- ut310--------
    rs1434564141,2
    --9868631(+) CTGGTG/TTCCAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CLECL1 (9868456 - 9885895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CLECL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv466e1CNV Complex17122850
    dgv474e1CNV Complex17122850
    dgv468e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607467    OMIM disorders: --

    7 diseases for CLECL1:    About MalaCards
    tonsillitis    acute myeloid leukemia    hepatitis b    myeloid leukemia
    multiple sclerosis    hepatitis    leukemia


    CLECL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CLECL1
    Human Genome Epidemiology (HuGE) Navigator: CLECL1 (1 document)

    Export disorders for CLECL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CLECL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CLECL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dendritic cell-associated lectin-1: a novel dendritic cell- associated, C-type lectin-like molecule enhances T cell secretion of IL-4. (PubMed id 12421943)1, 2, 3, 9 Ryan E.J.... Clark E.A. (2002)
    2. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)
    3. Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells. (PubMed id 19027044)1, 9 Ryan E.J....Clark E.A. (2009)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    5. Targeting C-type lectin-like molecule-1 for antibody- mediated immunotherapy in acute myeloid leukemia. (PubMed id 19648166)1 Zhao X....Korver W. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 160365 HGNC: 24462 AceView: DCAL1 Ensembl:ENSG00000184293 euGenes: HUgn160365
    ECgene: CLECL1 H-InvDB: CLECL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CLECL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CLECL1 gene:
    Search GeneIP for patents involving CLECL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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